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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621405
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hey2
Name: hes-related family bHLH transcription factor with YRPW motif 2
Acc ID: CHEBI:9948
Term: verapamil
Definition: A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hey2multiple interactionsISOHey2 (Mus musculus)6480464CTDVerapamil promotes the reaction [Diethylhexyl Phthalate results in decreased expression of HEY2 mRNA]; Verapamil promotes the reaction [Diethylhexyl Phthalate results in decreased expression of HEY2 protein]; Verapamil promotes the reaction [Diethylhexyl Phthalate results in increased expression of HEY2 mRNA]PMID:31086358
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