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GENE - TERM ANNOTATION REPORT

RGD ID: 2889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il18
Name: interleukin 18
Acc ID: DOID:9002798
Term: Macrophage Activation Syndrome
Definition: A serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T-LYMPHOCYTES and MACROPHAGES. It is seen predominantly in children with systemic onset JUVENILE IDIOPATHIC ARTHRITIS.
Definition Source(s): MESH:D055501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il18 ISOIL18 (Homo sapiens)8655917RGDassociated with Arthritis, Juvenile;protein:increased expression:serum 
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