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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1563329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dchs2
Name: dachsous cadherin-related 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dchs2affects methylationISODCHS2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of DCHS2 exon; Benzo(a)pyrene affects the methylation of DCHS2 intron; Benzo(a)pyrene affects the methylation of DCHS2 promoterPMID:27901495 PMID:30157460
Dchs2decreases expressionISODCHS2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of DCHS2 mRNAPMID:32234424
Dchs2increases methylationISODCHS2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of DCHS2 5' UTRPMID:27901495
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