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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561420
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il27
Name: interleukin 27
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il27increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of IL27 mRNAPMID:21742974
Il27multiple interactionsEXP 6480464CTDMIRLET7I mRNA affects the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]PMID:21742974
Il27increases expressionISOIL27 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IL27 mRNAPMID:30421605 PMID:35811015
Il27increases expressionISOIl27 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of IL27 mRNAPMID:19426678 PMID:26582142
Il27increases secretionISOIl27 (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of IL27 proteinPMID:22118570
Il27multiple interactionsISOIL27 (Homo sapiens)6480464CTDS-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]PMID:35811015
Il27multiple interactionsISOIl27 (Mus musculus)6480464CTDI-152 compound promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of and results in increased secretion of IL27 protein]; Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of IL27 protein]; Lipopolysaccharides affects the susceptibility to [indole-3-carbinol results in decreased expression of IL27 mRNA]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]; resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL27 protein]PMID:19426678 PMID:21948866 PMID:22118570 PMID:23536773
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