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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550022
Species: Mus musculus
RGD Object: Gene
Symbol: Gnaq
Name: guanine nucleotide binding protein, alpha q polypeptide
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gnaqdecreases expressionISOGnaq (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of GNAQ mRNAPMID:25181051
Gnaqincreases expressionISOGnaq (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of GNAQ mRNAPMID:29097150 PMID:32145629
Gnaqmultiple interactionsISOGNAQ (Homo sapiens)6480464CTD[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form]; bisphenol A inhibits the reaction [ESR1 protein binds to GNAQ protein]PMID:28751236 PMID:29389661
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