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GENE - TERM ANNOTATION REPORT

RGD ID: 1351155
Species: Homo sapiens
RGD Object: Gene
Symbol: MRGPRG
Name: MAS related GPR family member G
Acc ID: GO:0007186
Term: G protein-coupled receptor signaling pathway
Definition: The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
Definition Source(s): GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MRGPRGinvolved_inIBAMGI:3033095 or MGI:3033100 or MGI:96918 or PANTHER:PTN000140598150520179GO_Central GO_REF:0000033
MRGPRGinvolved_inIEAInterPro:IPR000276 or InterPro:IPR026234 or InterPro:IPR027336150520179InterPro GO_REF:0000002
MRGPRGinvolved_inIEAUniProtKB-KW:KW-0297150520179UniProt GO_REF:0000043
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