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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1affects expressionISOSirt1 (Mus musculus)6480464CTDAcetaminophen affects the expression of SIRT1 mRNAPMID:17562736
Sirt1affects response to substanceISOSIRT1 (Homo sapiens)6480464CTDSIRT1 affects the susceptibility to AcetaminophenPMID:31077331
Sirt1affects response to substanceISOSirt1 (Mus musculus)6480464CTDSIRT1 affects the susceptibility to AcetaminophenPMID:31077331
Sirt1increases expressionISOSIRT1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of SIRT1 mRNA; Acetaminophen results in increased expression of SIRT1 proteinPMID:21420995 PMID:29067470 PMID:31077331
Sirt1increases expressionISOSirt1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of SIRT1 mRNA; Acetaminophen results in increased expression of SIRT1 proteinPMID:31077331
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTDMIR19B1 inhibits the reaction [Acetaminophen results in increased expression of SIRT1 protein]; SIRT1 affects the reaction [Acetaminophen results in increased expression of CAT mRNA]; SIRT1 affects the reaction [Acetaminophen results in increased expression of GPX1 mRNA]; SIRT1 affects the reaction [Acetaminophen results in increased expression of SOD2 mRNA]PMID:31077331
Sirt1multiple interactionsISOSirt1 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA; Acetaminophen inhibits the reaction [Resveratrol results in increased expression of SIRT1 protein]; MIR19B-1 inhibits the reaction [Acetaminophen results in increased expression of SIRT1 protein]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA]; SIRT1 affects the reaction [Acetaminophen results in increased expression of CAT mRNA]; SIRT1 affects the reaction [Acetaminophen results in increased expression of GCLC mRNA]; SIRT1 affects the reaction [Acetaminophen results in increased expression of GPX1 mRNA]; SIRT1 affects the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]; SIRT1 affects the reaction [Acetaminophen results in increased expression of SOD2 mRNA]PMID:17585979 PMID:25956474 PMID:31077331
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