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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305216
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt6
Name: sirtuin 6
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt6decreases response to substanceISOSIRT6 (Homo sapiens)6480464CTDSIRT6 protein results in decreased susceptibility to ParaquatPMID:31216030
Sirt6decreases response to substanceISOSirt6 (Mus musculus)6480464CTDSIRT6 protein results in decreased susceptibility to ParaquatPMID:36356655
Sirt6decreases stabilityISOSirt6 (Mus musculus)6480464CTDParaquat results in decreased stability of SIRT6 protein mutant formPMID:31216030
Sirt6increases expressionISOSirt6 (Mus musculus)6480464CTDParaquat results in increased expression of SIRT6 mRNA; Paraquat results in increased expression of SIRT6 proteinPMID:36356655
Sirt6multiple interactionsISOSIRT6 (Homo sapiens)6480464CTD[SIRT6 protein results in decreased susceptibility to Paraquat] inhibits the reaction [NFE2L2 protein binds to HMOX1 enhancer]; NFE2L2 mRNA promotes the reaction [Paraquat promotes the reaction [SIRT6 protein binds to HMOX1 gene]]; Paraquat promotes the reaction [SIRT6 protein binds to HMOX1 gene]PMID:31216030
Sirt6multiple interactionsISOSirt6 (Mus musculus)6480464CTD[SIRT6 protein mutant form results in decreased activity of SIRT6 protein] inhibits the reaction [Paraquat promotes the reaction [SMARCA4 protein binds to HMOX1 enhancer]]; [SIRT6 protein mutant form results in decreased activity of SIRT6 protein] inhibits the reaction [Paraquat results in increased expression of HMOX1 mRNA]; Paraquat promotes the reaction [SIRT6 protein binds to HMOX1 gene]; Paraquat promotes the reaction [SMARCC2 protein binds to SIRT6 protein]; SIRT6 promotes the reaction [Paraquat results in increased expression of GCLC mRNA]; SIRT6 promotes the reaction [Paraquat results in increased expression of GCLM mRNA]; SIRT6 promotes the reaction [Paraquat results in increased expression of GSS mRNA]; SIRT6 promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; SIRT6 promotes the reaction [Paraquat results in increased expression of HSF1 mRNA]; SIRT6 promotes the reaction [Paraquat results in increased expression of NQO1 mRNA]; SIRT6 promotes the reaction [Paraquat results in increased expression of TXNRD1 mRNA]; SIRT6 protein affects the reaction [Paraquat results in increased cleavage of CASP3 protein]; SIRT6 protein promotes the reaction [Paraquat promotes the reaction [POLR2A protein modified form binds to HMOX1 gene]]; SIRT6 protein promotes the reaction [Paraquat promotes the reaction [SMARCA4 protein binds to HMOX1 enhancer]]; SIRT6 protein promotes the reaction [Paraquat promotes the reaction [SMARCC2 protein binds to HMOX1 enhancer]]PMID:31216030 PMID:36356655
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