Phenominer Database Results (195 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Average Type Value Units SEM SD Method Method Duration Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
BC/CpbU body weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. body mass female 77 days 4 177.0 g 2.5 5.0 body weighing method 0 12512 267
LEW/OlaHsd liver wet weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. liver mass female 77 days 4 8.1 g 0.2 0.4 post excision weight measurement 0 12552 267
ExHC/Seac white adipose tissue weight to body weight ratio controlled cholesterol content diet (1 %) (for 14 days) and controlled olive oil content diet (10 %) (for 14 days) Asahina M, et al., J Lipid Res 2005 Aug 1 white adipose mass male 42 days 7 1.7 g/100g 0.1 0.26 post excision weight measurement 0.0 0 Wako Pure Chemicals, Tokyo, Japan 67608 71
BN-Lx/Cub liver cholesterol level controlled olive oil content diet (5 %) (for 28 days) then controlled cholesterol content diet (2 %) (for 28 days) Bottger A, et al., Biochem Biophys Res Commun 1998 May 8;246(1):272-5. liver cholesterol amount not specified 77 days 0 70.99 mg/g enzymatic cholesterol assay 0.0 0 cholesterol measurement test umole/g, liver cholesterol measurement 68977 1036
LEW/OlaHsd serum phospholipid level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood phospholipid amount female 49 days-77 days 6 2.64 mmol/l 0.25 0.62 enzymatic lipid assay 0.0 0 68622 271
SHR.BN-(D10Mgh3-D10Rat85)/Ipcv liver triglyceride level controlled cholesterol content diet (2 %) (for 28 days) Pravenec M, et al., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10. liver triglyceride amount male 77 days 8 24.87 mg/g 1.33 3.75 enzymatic cholesterol assay 0.0 0 tissue triglyceride measurement test liver triglyceride, umol/g 68990 1039
BN-Lx/Cub serum intermediate density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood IDL cholesterol amount not specified 77 days 4 12.74 mg/dl 1.16 2.32 serum intermediate-density lipoprotein cholesterol measurement test 0.0 0 serum intermediate density lipoprotein-cholesterol measurement test serum intermediate density lipoprotein cholesterol level 68930 1030
BN-Lx/Cub serum high density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL cholesterol amount not specified 77 days 4 32.82 mg/dl 0.39 0.77 serum high-density lipoprotein-cholesterol measurement test 0.0 0 68934 1030
BN-Lx/Cub serum phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood phospholipid amount not specified 77 days 4 1.51 mmol/l 0.03 0.06 serum total phospholipid measurement test 0.0 0 serum total phospholipid measurement test 68936 1030
BN-Lx/Cub serum very low density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood VLDL phospholipid amount not specified 77 days 4 0.4 mmol/l 0.02 0.04 serum very low-density lipoprotein phospholipid measurement test 0.0 0 serum very low-density lipoprotein phospholipid measurement test serum very low density lipoprotein phospholipid level 68938 1030
SHR/OlaIpcv serum low density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood LDL phospholipid amount not specified 77 days 5 0.08 mmol/l 0.01 0.02 serum low-density lipoprotein phospholipid measurement test 0.0 0 serum low lipoprotein phospholipid measurement test serum low density lipoprotein phospholipid level 68943 1030
SHR.BN-RT1n serum low density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood LDL cholesterol amount not specified 77 days 0 7.72 mg/dl 0.39 serum low-density lipoprotein-cholesterol measurement test 0.0 0 strain SHR.1N 68947 1030
BC/CpbU liver copper weight to liver wet weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount female 77 days 4 8.1 ug/g 1.2 2.4 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec liver copper to liver wet wt 69844 267
LEW/OlaHsd liver copper weight to liver dry weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount female 77 days 4 18.0 ug/g 2.25 4.5 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69850 267
WKY plasma total cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood cholesterol amount male 0 days 7 66.02 mg/dl 3.86 10.22 enzymatic cholesterol assay 0.0 0 98903 2178
WKY plasma low density lipoprotein cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood LDL cholesterol amount male 0 days 7 7.72 mg/dl 0.77 2.04 enzymatic cholesterol assay 0.0 0 98911 2178
GK/Jpe body weight gain controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. body mass male 450 days-540 days 10 50.1 g 6.4 20.24 body weighing method 0.0 0 108002 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) then fasting (for 15 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 129.6 mg/dl 4.5 14.23 blood glucose test strip read by electrochemical glucometer 0.0 0 108007 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) then fasting (for 15 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 122.3 mg/dl 9.3 29.41 blood glucose test strip read by electrochemical glucometer 0.0 0 108008 3108
GK/Jpe plasma free fatty acids level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood free fatty acid amount male 540 days 10 0.69 mmol/l 0.09 0.28 enzymatic lipid assay 0.0 0 108016 3108
GK/Jpe urine albumin excretion rate controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. urine albumin amount male 540 days 10 17.8 mg/d 2.9 9.17 urine albumin analysis 0.0 0 108023 3108
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.11 0.29 tissue force analysis utilizing a force transducer 0.0 0 109112 3108
GK/Jpe serum triglyceride level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood triglyceride amount male 540 days 7 116.81 mg/dl 14.16 37.46 colorimetry 0.0 0 110884 3193
GK/Jpe serum albumin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood albumin amount male 540 days 7 2.4 g/dl 0.04 0.11 blood protein analysis 0.0 0 110889 3193
GK/Jpe liver weight to body weight ratio controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 19.1 g/kg 1.1 2.91 post excision weight measurement 0.0 0 110858 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 122.04 mg/dl 5.4 14.29 blood glucose test strip read by electrochemical glucometer 0.0 0 110864 3193
GK/Jpe hepatic extraction fraction controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. xenobiotic pharmacokinetics trait male 540 days 7 94.6 % 1.8 4.76 scintigraphy 0.0 0 110919 3193
GK/Jpe serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 5.7 null 0.4 1.06 blood enzyme activity assay 0.0 0 110938 3193
GK/Jpe liver weight to body weight ratio controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 27.1 g/kg 0.7 1.85 post excision weight measurement 0.0 0 110857 3193
GK/Jpe serum total bilirubin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood bilirubin amount male 540 days 7 0.18 mg/dl 0.02 0.05 ex vivo blood analysis 0.0 0 110894 3193
GK/Jpe serum alkaline phosphatase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alkaline phosphatase amount male 540 days 7 114.8 U/l 7.8 20.64 blood enzyme activity assay 0.0 0 110909 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 363.6 mg/dl 9.0 23.81 intraperitoneal glucose tolerance test 0.0 0 110869 3193
GK/Jpe serum non-high density lipoprotein cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 2.23 mmol/l 0.48 1.27 colorimetry 0.0 0 110878 3193
BC/CpbU body weight controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. body mass male 77 days 6 223.0 g 6.94 17.0 body weighing method 0 12602 271
SHR.BN-(D10Mgh3-Srebf1)/Ipcv systolic blood pressure controlled cholesterol content diet (2 %) (for 28 days) Pravenec M, et al., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10. arterial blood pressure trait male 70 days-77 days 8 serial mean 150.0 mmHg 2.2 6.22 radiotelemetry 0.0 0 5 s every 5 min for a week 68994 1039
BN/Seac serum total cholesterol level controlled cholesterol content diet (1 %) (for 14 days) and controlled olive oil content diet (10 %) (for 14 days) Asahina M, et al., J Lipid Res 2005 Aug 1 blood cholesterol amount male 42 days 11 211.0 mg/dl 8.9 29.52 serum total cholesterol measurement test 0 Wako Pure Chemicals, Tokyo, Japan 13145 71
BC/CpbU serum aldosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood aldosterone amount male 49 days-77 days 6 1.38 nmol/l 0.18 0.44 radioimmunoassay 0.0 0 68623 271
LEW/OlaHsd serum aldosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood aldosterone amount male 49 days-77 days 6 0.8 nmol/l 0.13 0.31 radioimmunoassay 0.0 0 68625 271
GK/Jpe serum alkaline phosphatase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alkaline phosphatase amount male 540 days 7 157.3 U/l 9.8 25.93 blood enzyme activity assay 0.0 0 110908 3193
HTG liver triglyceride level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. liver triglyceride amount male 0 days 7 20.42 mg/g 0.91 2.41 enzymatic triglyceride assay 0.0 0 98901 2178
LEW/OlaHsd body weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. body mass female 77 days 4 224.0 g 6.0 12.0 body weighing method 0 12538 267
BC/CpbU liver wet weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. liver mass male 77 days 4 10.0 g 0.6 1.2 post excision weight measurement 0.0 0 12548 267
BC/CpbU liver weight to body weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. liver mass male 77 days 4 45.2 g/kg 1.3 2.6 post excision weight measurement 0 12577 267
BC/CpbU liver weight to body weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. liver mass female 77 days 4 52.2 g/kg 0.65 1.3 post excision weight measurement 0 12578 267
LEW/OlaHsd serum aldosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood aldosterone amount female 49 days-77 days 6 0.63 nmol/l 0.13 0.32 radioimmunoassay 0.0 0 68626 271
LEW/OlaHsd serum corticosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood corticosterone amount female 49 days-77 days 6 204.0 nmol/l 89.41 219.0 radioimmunoassay 0.0 0 68630 271
SHR/OlaIpcv serum phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood phospholipid amount not specified 77 days 5 1.31 mmol/l 0.03 0.07 serum total phospholipid measurement test 0.0 0 serum total phospholipid measurement test 68937 1030
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv serum high density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL cholesterol amount not specified 77 days 0 35.91 mg/dl 1.16 serum high-density lipoprotein-cholesterol measurement test 0.0 0 68950 1030
SHR.BN-RT1n serum high density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL phospholipid amount not specified 77 days 0 0.44 mmol/l 0.02 serum high-density lipoprotein phospholipid measurement test 0.0 0 serum high lipoprotein phospholipid measurement test strain shr.1n - serum high density lipoprotein phospholipid level 68954 1030
LEW/OlaHsd liver copper weight to liver wet weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount female 77 days 4 7.9 ug/g 1.0 2.0 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec liver copper to liver wet wt 69846 267
BC/CpbU liver copper weight to body weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount male 77 days 4 39.3 ug/100 g 4.0 8.0 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69855 267
LEW/OlaHsd liver copper weight to body weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount male 77 days 4 23.7 ug/100 g 0.35 0.7 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69857 267
LEW/OlaHsd liver copper weight to body weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount female 77 days 4 28.8 ug/100 g 3.9 7.8 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69858 267
LEW/OlaHsd liver cholesterol level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. liver cholesterol amount female 49 days-77 days 6 74.62 mg/g 5.68 13.92 enzymatic lipid assay 0.0 0 84698 271
HTG plasma very low density lipoprotein cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood VLDL cholesterol amount male 0 days 7 11.58 mg/dl 1.54 4.09 enzymatic cholesterol assay 0.0 0 98909 2178
HTG plasma low density lipoprotein cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood LDL cholesterol amount male 0 days 7 11.97 mg/dl 1.54 4.09 enzymatic cholesterol assay 0.0 0 98913 2178
GK/Jpe serum aspartate aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 154.0 U/l 12.4 32.81 blood enzyme activity assay 0.0 0 110898 3193
GK/Jpe serum alanine aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alanine transaminase amount male 540 days 7 27.0 U/l 2.0 5.29 blood enzyme activity assay 0.0 0 110903 3193
GK/Jpe serum alkaline phosphatase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alkaline phosphatase amount male 540 days 7 125.2 U/l 7.4 19.58 blood enzyme activity assay 0.0 0 110910 3193
GK/Jpe serum gamma-glutamyltransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood gamma-glutamyltransferase amount male 540 days 7 1.6 U/l 0.2 0.53 blood enzyme activity assay 0.0 0 110914 3193
GK/Jpe body weight gain controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. body mass male 450 days-540 days 10 7.6 g 2.6 8.22 body weighing method 0.0 0 108001 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 419.1 mg/dl 28.5 90.12 intraperitoneal glucose tolerance test 0.0 120 min 108011 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 365.6 mg/dl 9.5 30.04 intraperitoneal glucose tolerance test 0.0 120 min 108013 3108
GK/Jpe urine albumin excretion rate controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. urine albumin amount male 540 days 10 30.9 mg/d 2.8 8.85 urine albumin analysis 0.0 0 108022 3108
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.23 null 0.23 0.61 tissue force analysis utilizing a force transducer 0.0 0 109097 3108
GK/Jpe plasma malondialdehyde level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood malondialdehyde amount male 540 days 7 1.11 umol/l 0.1 0.26 high-performance liquid chromatography 0.0 0 110925 3193
GK/Jpe plasma malondialdehyde level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood malondialdehyde amount male 540 days 7 1.42 umol/l 0.2 0.53 high-performance liquid chromatography 0.0 0 110924 3193
GK/Jpe serum uric acid level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood uric acid amount male 540 days 7 0.02 umol/l 0.0 0.0 blood uric acid analysis 0.0 0 110935 3193
GK/Jpe liver weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 11.05 g 0.2 0.53 post excision weight measurement 0.0 0 110852 3193
GK/Jpe liver weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 8.32 g 0.6 1.59 post excision weight measurement 0.0 0 110853 3193
GK/Jpe liver weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 6.37 g 0.8 2.12 post excision weight measurement 0.0 0 110854 3193
GK/Jpe serum gamma-glutamyltransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood gamma-glutamyltransferase amount male 540 days 7 1.9 U/l 0.1 0.26 blood enzyme activity assay 0.0 0 110913 3193
SHR/OlaIpcv serum intermediate density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood IDL cholesterol amount not specified 77 days 0 8.88 mg/dl 1.16 serum intermediate-density lipoprotein cholesterol measurement test 0.0 0 serum intermediate density lipoprotein-cholesterol measurement test serum intermediate density lipoprotein-cholesterol 75575 1030
BC/CpbU serum phospholipid level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood phospholipid amount female 49 days-77 days 6 1.61 mmol/l 0.07 0.17 enzymatic lipid assay 0.0 0 68484 271
LEW/OlaHsd serum corticosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood corticosterone amount male 49 days-77 days 6 46.0 nmol/l 16.74 41.0 radioimmunoassay 0.0 0 68629 271
BN/Seac white adipose tissue weight to body weight ratio controlled cholesterol content diet (1 %) (for 14 days) and controlled olive oil content diet (10 %) (for 14 days) Asahina M, et al., J Lipid Res 2005 Aug 1 white adipose mass male 42 days 11 0.5 g/100g 0.0 0.0 post excision weight measurement 0.0 0 67609 71
WKY liver cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. liver cholesterol amount male 0 days 7 5.89 mg/g 0.34 0.91 enzymatic cholesterol assay 0.0 0 98895 2178
WKY blood very low density lipoprotein triglyceride level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood VLDL triglyceride amount male 0 days 7 1.76 mg/dl 0.16 0.42 enzymatic triglyceride assay 0.0 0 98923 2178
BC/CpbU body weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. body mass male 77 days 4 220.0 g 10.5 21.0 body weighing method 0 12509 267
BC/CpbU serum total cholesterol level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood cholesterol amount male 77 days 6 93.82 mg/dl 5.83 14.29 enzymatic cholesterol assay 0 12627 271
BC/CpbU liver wet weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. liver mass female 77 days 4 9.3 g 0.2 0.4 post excision weight measurement 0 12550 267
LEW/OlaHsd liver weight to body weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. liver mass female 77 days 4 36.3 g/kg 0.35 0.7 post excision weight measurement 0 12581 267
BC/CpbU serum phospholipid level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood phospholipid amount male 49 days-77 days 6 1.51 mmol/l 0.08 0.19 enzymatic lipid assay 0.0 0 68483 271
SHR.BN-(D10Mgh3-Srebf1)/Ipcv liver triglyceride level controlled cholesterol content diet (2 %) (for 28 days) Pravenec M, et al., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10. liver triglyceride amount male 77 days 5 33.54 mg/g 2.48 5.54 enzymatic cholesterol assay 0.0 0 tissue triglyceride measurement test liver triglyceride, umol/g 68992 1039
SHR/OlaIpcv serum low density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood LDL cholesterol amount not specified 77 days 5 11.2 mg/dl 1.16 2.59 serum low-density lipoprotein-cholesterol measurement test 0.0 0 68933 1030
SHR/OlaIpcv serum high density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL cholesterol amount not specified 77 days 5 28.19 mg/dl 1.16 2.59 serum high-density lipoprotein-cholesterol measurement test 0.0 0 68935 1030
BN-Lx/Cub serum intermediate density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood IDL phospholipid amount not specified 77 days 4 0.2 mmol/l 0.03 0.06 serum intermediate-density lipoprotein phospholipid measurement test 0.0 0 serum intermediate lipoprotein phospholipid measurement test serum intermediate density lipoprotein phospholipid level 68940 1030
SHR/OlaIpcv serum intermediate density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood IDL phospholipid amount not specified 77 days 5 0.08 mmol/l 0.01 0.02 serum intermediate-density lipoprotein phospholipid measurement test 0.0 0 serum intermediate lipoprotein phospholipid measurement test serum intermediate density lipoprotein phospholipid level 68941 1030
BN-Lx/Cub serum low density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood LDL phospholipid amount not specified 77 days 4 0.11 mmol/l 0.02 0.04 serum low-density lipoprotein phospholipid measurement test 0.0 0 serum low lipoprotein phospholipid measurement test serum low density lipoprotein phospholipid level 68942 1030
SHR/OlaIpcv serum high density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL phospholipid amount not specified 77 days 5 0.45 mmol/l 0.01 0.02 serum high-density lipoprotein phospholipid measurement test 0.0 0 serum high lipoprotein phospholipid measurement test serum high density lipoprotein phospholipid level 68945 1030
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv serum intermediate density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood IDL cholesterol amount not specified 77 days 0 3.86 mg/dl 1.93 serum intermediate-density lipoprotein cholesterol measurement test 0.0 0 serum intermediate density lipoprotein-cholesterol measurement test serum intermediate density lipoprotein-cholesterol 68948 1030
SHR.BN-RT1n serum high density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL cholesterol amount not specified 77 days 0 35.52 mg/dl 1.93 serum high-density lipoprotein-cholesterol measurement test 0.0 0 strain SHR.1N 68951 1030
SHR/OlaIpcv serum high density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL phospholipid amount not specified 77 days 0 0.31 mmol/l 0.01 serum high-density lipoprotein phospholipid measurement test 0.0 0 serum high lipoprotein phospholipid measurement test strain shr - serum high density lipoprotein phospholipid level 68952 1030
SHR/OlaIpcv serum total cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood cholesterol amount not specified 77 days 5 77.61 mg/dl 2.7 6.04 serum total cholesterol measurement test 0.0 0 68927 1030
BC/CpbU liver copper weight to liver dry weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount female 77 days 4 18.7 ug/g 2.85 5.7 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69848 267
LEW/OlaHsd liver copper weight to liver dry weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount male 77 days 4 15.2 ug/g 0.6 1.2 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69849 267
BC/CpbU liver total copper weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount female 77 days 4 75.2 ug 11.75 23.5 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69852 267
BC/CpbU liver copper weight to body weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount female 77 days 4 42.4 ug/100 g 6.5 13.0 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69856 267
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.16 null 0.07 0.19 tissue force analysis utilizing a force transducer 0.0 0 109096 3108
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.4 null 0.02 0.04 tissue force analysis utilizing a force transducer 0.0 0 109106 3108
GK/Jpe serum albumin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood albumin amount male 540 days 7 2.6 g/dl 0.04 0.11 blood protein analysis 0.0 0 110887 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 129.42 mg/dl 5.4 14.29 blood glucose test strip read by electrochemical glucometer 0.0 0 110863 3193
GK/Jpe hepatic extraction fraction controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. xenobiotic pharmacokinetics trait male 540 days 7 87.0 % 2.9 7.67 scintigraphy 0.0 0 110918 3193
GK/Jpe plasma free fatty acids level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood free fatty acid amount male 540 days 10 0.9 mmol/l 0.12 0.38 enzymatic lipid assay 0.0 0 108017 3108
GK/Jpe urine albumin excretion rate controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. urine albumin amount male 540 days 10 35.7 mg/d 4.1 12.97 urine albumin analysis 0.0 0 108021 3108
GK/Jpe serum uric acid level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood uric acid amount male 540 days 7 0.03 umol/l 0.0 0.01 blood uric acid analysis 0.0 0 110934 3193
GK/Jpe serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 3.9 null 0.2 0.53 blood enzyme activity assay 0.0 0 110940 3193
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 70.0 % 2.1 5.56 tissue force analysis utilizing a force transducer 0.0 0 109103 3108
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.25 null 0.07 0.19 tissue force analysis utilizing a force transducer 0.0 0 109108 3108
GK/Jpe body weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. body mass male 540 days 7 433.9 g 10.9 28.84 body weighing method 0.0 0 110849 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 418.68 mg/dl 28.8 76.2 intraperitoneal glucose tolerance test 0.0 0 110867 3193
GK/Jpe serum total cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 618.15 mg/dl 115.83 306.46 colorimetry 0.0 0 110877 3193
LEW/OlaHsd serum total cholesterol level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood cholesterol amount male 77 days 6 174.52 mg/dl 22.86 55.98 enzymatic cholesterol assay 0 12631 271
LEW/OlaHsd body weight controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. body mass female 77 days 6 219.0 g 4.9 12.0 body weighing method 0 12612 271
LEW/OlaHsd serum phospholipid level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood phospholipid amount male 49 days-77 days 6 1.65 mmol/l 0.19 0.46 enzymatic lipid assay 0.0 0 68621 271
BC/CpbU serum corticosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood corticosterone amount male 49 days-77 days 6 184.0 nmol/l 89.41 219.0 radioimmunoassay 0.0 0 68627 271
GK/Jpe serum aspartate aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 176.0 U/l 7.4 19.58 blood enzyme activity assay 0.0 0 110897 3193
GK/Jpe serum gamma-glutamyltransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood gamma-glutamyltransferase amount male 540 days 7 1.3 U/l 0.2 0.53 blood enzyme activity assay 0.0 0 110915 3193
WKY plasma triglyceride level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood triglyceride amount male 0 days 7 0.67 mmol/l 0.04 0.11 enzymatic triglyceride assay 0.0 0 98919 2178
HTG blood very low density lipoprotein triglyceride level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood VLDL triglyceride amount male 0 days 7 2.08 mg/dl 0.28 0.74 enzymatic triglyceride assay 0.0 0 98925 2178
BN/Seac serum triglyceride level controlled cholesterol content diet (1 %) (for 14 days) and controlled olive oil content diet (10 %) (for 14 days) Asahina M, et al., J Lipid Res 2005 Aug 1 blood triglyceride amount male 42 days 11 79.0 mg/dl 13.3 44.11 serum triglyceride analysis 0 Wako Pure Chemicals, Tokyo, Japan 13146 71
BC/CpbU serum total cholesterol level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood cholesterol amount female 77 days 6 148.26 mg/dl 9.46 23.17 enzymatic cholesterol assay 0 12629 271
LEW/OlaHsd body weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. body mass male 77 days 4 352.0 g 17.0 34.0 body weighing method 0 12514 267
LEW/OlaHsd liver wet weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. liver mass male 77 days 4 13.4 g 0.9 1.8 post excision weight measurement 0 12551 267
BC/CpbU body weight controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. body mass female 77 days 6 177.0 g 1.63 4.0 body weighing method 0 12606 271
SHR.BN-(D10Mgh3-D10Rat85)/Ipcv systolic blood pressure controlled cholesterol content diet (2 %) (for 28 days) Pravenec M, et al., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10. arterial blood pressure trait male 70 days-77 days 8 serial mean 150.0 mmHg 1.3 3.68 radiotelemetry 0.0 0 5 s every 5 min for a week 68993 1039
BN-Lx/Cub serum very low density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood VLDL cholesterol amount not specified 77 days 4 56.76 mg/dl 3.86 7.72 serum very low-density lipoprotein-cholesterol measurement test 0.0 0 68928 1030
SHR/OlaIpcv serum very low density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood VLDL cholesterol amount not specified 77 days 5 31.27 mg/dl 4.25 9.5 serum very low-density lipoprotein-cholesterol measurement test 0.0 0 68929 1030
BN-Lx/Cub serum low density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood LDL cholesterol amount not specified 77 days 4 14.29 mg/dl 1.93 3.86 serum low-density lipoprotein-cholesterol measurement test 0.0 0 68932 1030
SHR/OlaIpcv serum very low density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood VLDL phospholipid amount not specified 77 days 5 0.2 mmol/l 0.03 0.07 serum very low-density lipoprotein phospholipid measurement test 0.0 0 serum very low density lipoprotein phospholipid level 68939 1030
BN-Lx/Cub serum high density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL phospholipid amount not specified 77 days 4 0.2 mmol/l 0.03 0.06 serum high-density lipoprotein phospholipid measurement test 0.0 0 serum high lipoprotein phospholipid measurement test serum high density lipoprotein phospholipid level 68944 1030
SHR.BN-RT1n serum intermediate density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood IDL cholesterol amount not specified 77 days 0 5.02 mg/dl 0.77 serum intermediate-density lipoprotein cholesterol measurement test 0.0 0 serum intermediate density lipoprotein-cholesterol measurement test strain shr.1n - serum intermediate density lipoprotein-cholesterol 68949 1030
LEW/OlaHsd liver copper weight to liver wet weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount male 77 days 4 6.3 ug/g 0.2 0.4 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec liver copper to liver wet wt 69845 267
BC/CpbU liver total copper weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount male 77 days 4 85.3 ug 5.0 10.0 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69851 267
LEW/OlaHsd liver total copper weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount male 77 days 4 83.3 ug 3.15 6.3 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69853 267
BC/CpbU liver cholesterol level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. liver cholesterol amount female 49 days-77 days 6 63.41 mg/g 3.31 8.12 enzymatic lipid assay 0.0 0 84696 271
WKY plasma high density lipoprotein cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood HDL cholesterol amount male 0 days 7 21.62 mg/dl 1.54 4.09 enzymatic cholesterol assay 0.0 0 98915 2178
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.15 0.4 tissue force analysis utilizing a force transducer 0.0 0 109111 3108
GK/Jpe serum triglyceride level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood triglyceride amount male 540 days 7 196.46 mg/dl 37.17 98.34 colorimetry 0.0 0 110883 3193
GK/Jpe serum albumin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood albumin amount male 540 days 7 2.7 g/dl 0.06 0.16 blood protein analysis 0.0 0 110888 3193
GK/Jpe serum aspartate aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 151.0 U/l 8.7 23.02 blood enzyme activity assay 0.0 0 110899 3193
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then fasting (between 15 and 0.2 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 151.7 mg/dl 7.9 24.98 blood glucose test strip read by electrochemical glucometer 0.0 0 108006 3108
GK/Jpe plasma free fatty acids level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood free fatty acid amount male 540 days 10 0.89 mmol/l 0.06 0.19 enzymatic lipid assay 0.0 0 108018 3108
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 151.56 mg/dl 7.2 19.05 blood glucose test strip read by electrochemical glucometer 0.0 0 110862 3193
GK/Jpe urine 8-hydroxy-2'-deoxyguanosine level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. urine molecular composition trait male 540 days 7 302.37 ng/d 42.34 112.02 enzyme linked immunosorbent assay 0.0 0 110929 3193
GK/Jpe plasma malondialdehyde level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood malondialdehyde amount male 540 days 7 1.8 umol/l 0.1 0.26 high-performance liquid chromatography 0.0 0 110923 3193
GK/Jpe hepatic extraction fraction controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. xenobiotic pharmacokinetics trait male 540 days 7 97.8 % 1.74 4.6 scintigraphy 0.0 0 110920 3193
GK/Jpe serum uric acid level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood uric acid amount male 540 days 7 0.03 umol/l 0.0 0.01 blood uric acid analysis 0.0 0 110933 3193
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.05 0.13 tissue force analysis utilizing a force transducer 0.0 0 109113 3108
GK/Jpe serum total cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 705.4 mg/dl 118.15 312.59 colorimetry 0.0 0 110872 3193
GK/Jpe serum total cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 145.56 mg/dl 21.62 57.21 colorimetry 0.0 0 110873 3193
GK/Jpe serum non-high density lipoprotein cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 1.11 mmol/l 0.16 0.42 colorimetry 0.0 0 110879 3193
LEW/OlaHsd body weight controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. body mass male 77 days 6 341.0 g 14.29 35.0 body weighing method 0 12610 271
LEW/OlaHsd serum total cholesterol level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood cholesterol amount female 77 days 6 603.47 mg/dl 96.15 235.52 enzymatic cholesterol assay 0 12643 271
BC/CpbU liver cholesterol level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. liver cholesterol amount male 49 days-77 days 6 66.89 mg/g 4.26 10.44 enzymatic lipid assay 0.0 0 umol/g 84695 271
GK/Jpe liver weight to body weight ratio controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 16.3 g/kg 1.9 5.03 post excision weight measurement 0.0 0 110859 3193
WKY liver triglyceride level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. liver triglyceride amount male 0 days 7 19.01 mg/g 1.98 5.24 enzymatic triglyceride assay 0.0 0 98899 2178
HTG plasma high density lipoprotein cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood HDL cholesterol amount male 0 days 7 29.34 mg/dl 1.93 5.11 enzymatic cholesterol assay 0.0 0 98917 2178
HTG plasma triglyceride level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood triglyceride amount male 0 days 7 0.74 mmol/l 0.1 0.26 enzymatic triglyceride assay 0.0 0 98921 2178
ExHC/Seac serum total cholesterol level controlled cholesterol content diet (1 %) (for 14 days) and controlled olive oil content diet (10 %) (for 14 days) Asahina M, et al., J Lipid Res 2005 Aug 1 blood cholesterol amount male 42 days 7 453.0 mg/dl 23.8 62.97 serum total cholesterol measurement test 0 Wako Pure Chemicals, Tokyo, Japan 13141 71
SHR/OlaIpcv liver cholesterol level controlled olive oil content diet (5 %) (for 28 days) then controlled cholesterol content diet (2 %) (for 28 days) Bottger A, et al., Biochem Biophys Res Commun 1998 May 8;246(1):272-5. liver cholesterol amount not specified 77 days 0 38.47 mg/g enzymatic cholesterol assay 0.0 0 cholesterol measurement test umole/g, liver cholesterol measurement 68976 1036
BC/CpbU serum aldosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood aldosterone amount female 49 days-77 days 6 1.44 nmol/l 0.21 0.52 radioimmunoassay 0.0 0 68624 271
BC/CpbU serum corticosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood corticosterone amount female 49 days-77 days 6 718.0 nmol/l 172.28 422.0 radioimmunoassay 0.0 0 68628 271
BN-Lx/Cub serum total cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood cholesterol amount not specified 77 days 4 120.85 mg/dl 2.32 4.63 serum total cholesterol measurement test 0.0 0 68926 1030
SHR/OlaIpcv serum intermediate density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood IDL cholesterol amount not specified 77 days 5 12.36 mg/dl 1.16 2.59 serum intermediate-density lipoprotein cholesterol measurement test 0.0 0 serum intermediate density lipoprotein-cholesterol measurement test serum intermediate density lipoprotein cholesterol level 68931 1030
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv serum low density lipoprotein cholesterol level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood LDL cholesterol amount not specified 77 days 0 6.18 mg/dl 1.16 serum low-density lipoprotein-cholesterol measurement test 0.0 0 68946 1030
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv serum high density lipoprotein phospholipid level controlled cholesterol content diet (2 %) (for 28 days) and controlled olive oil content diet (5 %) (for 28 days) then fasting (for 16 hours) Bottger A, et al., J Clin Invest 1996 Aug 1;98(3):856-62 blood HDL phospholipid amount not specified 77 days 0 0.44 mmol/l 0.01 serum high-density lipoprotein phospholipid measurement test 0.0 0 serum high lipoprotein phospholipid measurement test serum high density lipoprotein phospholipid level 68953 1030
BC/CpbU liver copper weight to liver dry weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount male 77 days 4 18.9 ug/g 1.8 3.6 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69847 267
LEW/OlaHsd liver total copper weight controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount female 77 days 4 64.0 ug 7.2 14.4 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec 69854 267
LEW/OlaHsd liver cholesterol level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. liver cholesterol amount male 49 days-77 days 6 47.17 mg/g 1.58 3.87 enzymatic lipid assay 0.0 0 84697 271
HTG plasma total cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood cholesterol amount male 0 days 7 65.64 mg/dl 3.09 8.17 enzymatic cholesterol assay 0.0 0 98905 2178
WKY plasma very low density lipoprotein cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood VLDL cholesterol amount male 0 days 7 8.11 mg/dl 0.77 2.04 enzymatic cholesterol assay 0.0 0 98907 2178
GK/Jpe body weight gain controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. body mass male 450 days-540 days 10 11.9 g 3.7 11.7 body weighing method 0.0 0 108003 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 g/kg) (for 90 days) then soybean oil (2 ml/kg) then fasting (2 ml/kg) (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 338.6 mg/dl 23.4 74.0 intraperitoneal glucose tolerance test 0.0 120 min 108012 3108
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.6 null 0.1 0.26 tissue force analysis utilizing a force transducer 0.0 0 109098 3108
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 49.0 % 3.2 8.47 tissue force analysis utilizing a force transducer 0.0 0 109101 3108
GK/Jpe serum triglyceride level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood triglyceride amount male 540 days 7 551.33 mg/dl 84.96 224.77 colorimetry 0.0 0 110882 3193
GK/Jpe serum total bilirubin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood bilirubin amount male 540 days 7 0.14 mg/dl 0.04 0.11 ex vivo blood analysis 0.0 0 110893 3193
GK/Jpe body weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. body mass male 540 days 7 410.9 g 5.1 13.49 body weighing method 0.0 0 110861 3193
GK/Jpe urine 8-hydroxy-2'-deoxyguanosine level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. urine molecular composition trait male 540 days 7 415.8 ng/d 74.29 196.55 enzyme linked immunosorbent assay 0.0 0 110928 3193
GK/Jpe urine 8-hydroxy-2'-deoxyguanosine level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. urine molecular composition trait male 540 days 7 5.63 ng/d 0.36 0.95 enzyme linked immunosorbent assay 0.0 0 110930 3193
GK/Jpe serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 4.2 null 0.2 0.53 blood enzyme activity assay 0.0 0 110937 3193
GK/Jpe body weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. body mass male 540 days 7 428.8 g 12.0 31.75 body weighing method 0.0 0 110848 3193
GK/Jpe serum total cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 92.28 mg/dl 10.42 27.58 colorimetry 0.0 0 110874 3193
GK/Jpe serum total bilirubin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood bilirubin amount male 540 days 7 0.14 mg/dl 0.02 0.05 ex vivo blood analysis 0.0 0 110892 3193
GK/Jpe serum alanine aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alanine transaminase amount male 540 days 7 40.1 U/l 4.3 11.38 blood enzyme activity assay 0.0 0 110902 3193
GK/Jpe serum alanine aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alanine transaminase amount male 540 days 7 37.5 U/l 1.3 3.44 blood enzyme activity assay 0.0 0 110904 3193
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 55.0 % 2.5 6.61 tissue force analysis utilizing a force transducer 0.0 0 109102 3108
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.47 null 0.03 0.08 tissue force analysis utilizing a force transducer 0.0 0 109107 3108
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 358.2 mg/dl 14.4 38.1 intraperitoneal glucose tolerance test 0.0 0 110868 3193
LEW/OlaHsd liver weight to body weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. liver mass male 77 days 4 38.0 g/kg 0.9 1.8 post excision weight measurement 0 12579 267
SHR/OlaIpcv liver triglyceride level controlled cholesterol content diet (2 %) (for 28 days) Pravenec M, et al., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10. liver triglyceride amount male 77 days 7 23.36 mg/g 0.88 2.34 enzymatic cholesterol assay 0.0 0 tissue triglyceride measurement test liver triglyceride, umol/g 68991 1039
ExHC/Seac serum triglyceride level controlled cholesterol content diet (1 %) (for 14 days) and controlled olive oil content diet (10 %) (for 14 days) Asahina M, et al., J Lipid Res 2005 Aug 1 blood triglyceride amount male 42 days 7 216.0 mg/dl 15.5 41.01 serum triglyceride analysis 0.0 0 Wako Pure Chemicals, Tokyo, Japan 13143 71
BC/CpbU liver copper weight to liver wet weight ratio controlled olive oil content diet (5 %) (for 30 days) and controlled cholesterol content diet (2 %) (for 30 days) de Wolf ID, et al., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34. hepatic copper amount male 77 days 4 8.7 ug/g 1.0 2.0 flame atomic absorption spectrometry 0.0 0 flame atomic absorption spec liver copper to liver wet wt 68482 267
HTG liver cholesterol level controlled cholesterol content diet (1 %) (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. liver cholesterol amount male 0 days 7 7.57 mg/g 0.62 1.65 enzymatic cholesterol assay 0.0 0 98897 2178