Phenominer Database Results (10000 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS.LEW-(D1Rat211-D1Rat18)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 180.0 mmHg 2.8 12.52 tail cuff plethysmography 0 0 average of 4days 65488 611
SS.LEW-(D1Mco4-D1Rat18)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 178.0 mmHg 2.3 10.29 tail cuff plethysmography 0 0 average of 4days 65489 611
SS/Jr absolute change in systolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) then controlled exposure to darkness then controlled exposure to ambient light Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 22.6 mmHg 1.05 2.97 intra-aortic abdominal radiotelemetry 10 0 diurnal difference 65497 611
SS.LEW-(D1Rat211-D1Rat18)/Mco absolute change in systolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) then controlled exposure to darkness then controlled exposure to ambient light Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 14.4 mmHg 1.63 4.61 intra-aortic abdominal radiotelemetry 10 0 diurnal difference 65502 611
SS.LEW-(D1Rat211-D1Rat18)/Mco pulse pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 49.0 mmHg 0.74 2.09 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65500 611
SS-Nox4em2Mcwi-/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 337.5 beats/min 6.5 9.19 radiotelemetry carotid artery 0 - 66625 717
SS-Ncf2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 130.6 mmHg 8.03 17.95 radiotelemetry carotid artery 0 - 66646 717
SS-Cybaem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 114.8 mmHg 7.13 15.94 radiotelemetry carotid artery 0 - 66652 717
SS-Mmp2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 137.0 mmHg radiotelemetry carotid artery 0 - 66654 717
SS-Gpr183em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 140.33 mmHg 10.48 18.15 radiotelemetry carotid artery 0 - 66653 717
SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 133.0 mmHg radiotelemetry carotid artery 0 - 66650 717
SS-Apoeem7Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 127.0 mmHg 6.16 13.77 radiotelemetry carotid artery 0 - 66656 717
SS-Nckap5em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 143.8 mmHg 8.4 18.78 radiotelemetry carotid artery 0 - 66657 717
SS-Rag1em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 7 1/3 systolic pressure + 2/3 diastolic pressure 123.14 mmHg 6.08 16.08 radiotelemetry carotid artery 0 - 66661 717
SS-Alms1em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 134.0 mmHg radiotelemetry carotid artery 0 - 66667 717
SS-Chr 5BN-Cyp4a2em1Mcwi-/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 116.67 mmHg 6.74 11.68 radiotelemetry carotid artery 0 - 66668 717
SS-Renem1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 155.25 mmHg 12.05 24.1 radiotelemetry carotid artery 0 - 66671 717
SS-Acad10em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 137.0 mmHg 3.78 8.46 radiotelemetry carotid artery 0 - 66686 717
SS-Chr 5BN-Cyp4a2em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 124.67 mmHg 2.17 5.32 radiotelemetry carotid artery 0 - 66681 717
SS-Nox4em2Mcwi-/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 122.0 mmHg 1.0 1.41 radiotelemetry carotid artery 0 - 66687 717
SS-Ulk4em3Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 4 11.99 mg/d 0.77 1.54 automated urine analysis 0 - 66695 717
SS-Chr 5BN-Cyp4a2em1Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 3 12.82 mg/d 0.99 1.71 automated urine analysis 0 - 66711 717
SS-Cybaem1Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 2 10.62 mg/d 0.03 0.04 automated urine analysis 0 - 66737 717
SS-Nox4em2Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 5 10.89 mg/d 0.69 1.53 automated urine analysis 0 - 66730 717
SS-Rag1em2Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 1 10.32 mg/d automated urine analysis 0 - 66735 717
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 2 8.94 mg/d 1.17 1.65 automated urine analysis 0 - 66738 717
SS-Alms1em1Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 6 1.27 g 0.08 0.2 post excision weight measurement 0 - 66753 717
SS-Ulk4em3Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 4 1.55 g 0.09 0.18 post excision weight measurement 0 - 66756 717
SS-Nckap5em2Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 8 1.71 g 0.05 0.14 post excision weight measurement 0 - 66767 717
SS-Nckap5em1Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 7 1.48 g 0.08 0.21 post excision weight measurement 0 - 66762 717
SS-Ncf2em1Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.44 g 0.03 0.07 post excision weight measurement 0 - 66769 717
SS-Ets1em1Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 4 1.57 g 0.06 0.11 post excision weight measurement 0 - 66778 717
SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 4 1.41 g 0.05 0.1 post excision weight measurement 0 - 66793 717
SS-Tfdp2em2Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 3 1.37 g 0.01 0.02 post excision weight measurement 0 - 66798 717
SS-Renem1Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 4 1.51 g 0.07 0.14 post excision weight measurement 0 - 66794 717
SS-Ncf2em1Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 6 11.43 mEq/d 0.64 1.56 automated urine analysis 0 - 66812 717
SS-Mmp2em1Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 6 4.75 mEq/d 0.62 1.51 automated urine analysis 0 - 66814 717
SS-Bcas3em4Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 3 5.79 mEq/d 1.3 2.25 automated urine analysis 0 - 66827 717
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 12 serial mean 126.0 mmHg 5.0 17.32 vascular indwelling catheter method left femoral artery 0 0 65465 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93 days 12 serial mean 427.0 beats/min 6.0 20.78 vascular indwelling catheter method left femoral artery 0 0 65469 151
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 95 days 11 9.6 ng/ml/h 1.0 3.32 ex vivo blood analysis 0 0 65474 151
SS/JrRkb heart right ventricle weight to body weight ratio controlled sodium content diet (4 %) (for 56 days) Wendt N, et al., J Hypertens. 2007 Jan;25(1):95-102. heart right ventricle mass male 98 days 14 0.58 mg/g 0.02 0.07 post excision weight measurement 0 0 66091 669
SS-Apoeem7Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 3 12.51 mEq/d 2.26 3.92 automated urine analysis 0 - 66836 717
SS-Nox4em2Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 5 9.51 mEq/d 0.72 1.61 automated urine analysis 0 - 66853 717
SS-Nckap5em3Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 2 10.65 mEq/d 0.47 0.67 automated urine analysis 0 - 66867 717
SS-Renem1Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 5 7.06 mEq/d 1.41 3.15 automated urine analysis 0 - 66863 717
SS-Ube2q2em3Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 2 11.4 mEq/d 1.5 2.13 automated urine analysis 0 - 66872 717
SS-Ube2q2em3Mcwi+/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 1 147.98 mg/d automated urine analysis 0 - 66880 717
SS-Nox4em2Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 5 17.0 mg/d 2.3 5.13 automated urine analysis 0 - 66914 717
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 2 29.99 mg/d 10.31 14.58 automated urine analysis 0 - 66922 717
SS-Mthfrem1Mcwi-/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 8 73.13 mg/d 19.06 53.91 automated urine analysis 0 - 66929 717
SS-Ube2q2em3Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 163.0 mmHg radiotelemetry carotid artery 0 - 66941 717
SS-Nckap5em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 130.67 mmHg 5.46 13.38 radiotelemetry carotid artery 0 - 66946 717
SS-Tgfb1em3Mcwi+/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 119.67 mmHg 10.14 17.56 radiotelemetry carotid artery 0 - 66945 717
SS-Apoeem8Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 144.0 mmHg 8.08 14.0 radiotelemetry carotid artery 0 - 66950 717
SS-Ncf2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 126.2 mmHg 6.27 14.03 radiotelemetry carotid artery 0 - 66953 717
SS-Apoeem7Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 123.0 mmHg 2.08 3.61 radiotelemetry carotid artery 0 - 66962 717
SS-Mmp2em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 142.0 mmHg 14.32 32.03 radiotelemetry carotid artery 0 - 66968 717
SS-Rag1em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 137.0 mmHg 6.1 12.19 radiotelemetry carotid artery 0 - 66971 717
SS-Tfdp2em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 142.0 mmHg 12.58 21.79 radiotelemetry carotid artery 0 - 66980 717
SS-Renem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 119.8 mmHg 7.3 16.32 radiotelemetry carotid artery 0 - 66984 717
SS-Ube2q2em3Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 122.5 mmHg 10.5 14.85 radiotelemetry carotid artery 0 - 66993 717
SS-Apoeem8Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 5 1.18 g 0.09 0.2 post excision weight measurement 0 - 67010 717
SS-Apoeem7Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 5 1.1 g 0.03 0.06 post excision weight measurement 0 - 67023 717
SS-Mas1em1Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 6 1.16 g 0.03 0.09 post excision weight measurement 0 - 67033 717
SS-Renem1Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 5 0.99 g 0.04 0.09 post excision weight measurement 0 - 67046 717
SS-Nckap5em3Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 2 1.15 g 0.11 0.16 post excision weight measurement 0 - 67050 717
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 397.0 beats/min 10.23 20.46 radiotelemetry carotid artery 0 - 67057 717
SS-Alms1em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 5 357.2 beats/min 13.07 29.22 radiotelemetry carotid artery 0 - 67059 717
SS-Gpr183em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 360.83 beats/min 12.35 30.26 radiotelemetry carotid artery 0 - 67061 717
SS-Ube2q2em3Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 383.0 beats/min radiotelemetry carotid artery 0 - 67063 717
SS-Gpr183em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 9 368.67 beats/min 12.2 36.59 radiotelemetry carotid artery 0 - 67070 717
SS-Nckap5em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 365.33 beats/min 11.89 29.12 radiotelemetry carotid artery 0 - 67073 717
SS-Cybaem1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 5 360.2 beats/min 10.44 23.35 radiotelemetry carotid artery 0 - 67080 717
SS-Nox4em2Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 374.33 beats/min 5.7 9.87 radiotelemetry carotid artery 0 - 67087 717
SS-Rag1em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 343.0 beats/min 14.92 36.56 radiotelemetry carotid artery 0 - 67088 717
SS-Apoeem8Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 336.0 beats/min radiotelemetry carotid artery 0 - 67091 717
SS-Rag1em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 353.0 beats/min 22.92 45.83 radiotelemetry carotid artery 0 - 67093 717
SS-Chr 5BN-Cyp4a2em1Mcwi-/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 360.67 beats/min 2.67 4.62 radiotelemetry carotid artery 0 - 67095 717
SS-Renem1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 358.0 beats/min 4.08 8.16 radiotelemetry carotid artery 0 - 67098 717
SS-Cybaem1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 327.0 beats/min 11.0 15.56 radiotelemetry carotid artery 0 - 67103 717
SS.LEW-(D18Rat61-D18Rat45)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 6 2.61 mg/g 0.08 0.2 post excision weight measurement 0 0 64900 226
SS.LEW-(D17Chm14-D17Rat181)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 5 2.7 mg/g 0.1 0.22 post excision weight measurement 0 0 64906 226
SS.LEW-(D18Rat61-D18Rat45)/Ayd heart right ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart right ventricle mass male 98 days 6 0.57 mg/g 0.01 0.02 post excision weight measurement 0 0 64901 226
SS.LEW-(D10Chm10-D10Rat11)/Ayd heart right ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart right ventricle mass male 98 days 7 0.57 mg/g 0.01 0.03 post excision weight measurement 0 0 64917 226
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) then controlled exposure to ambient light (for 12 hours) then controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-93 days 42 continuous mean 4.5 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 0.0 0 left femoral artery increase 64928 229
SS.LEW-(D3Rat61-D3Wox1)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 5 2.33 mg/g 0.04 0.09 post excision weight measurement 0 0 64939 226
SS.LEW-(D3Mco21-D3Rat17)/Ayd heart right ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart right ventricle mass male 98 days 4 0.6 mg/g 0.0 0.01 post excision weight measurement 0 0 64947 226
SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 39 and 40 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 107 days-109 days 4 148.8 mmHg 4.1 8.2 intra-aortic abdominal radiotelemetry 86400 0 65065 283
SS.SR-(D3Arb14-D3Mco36)/Mco diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 47 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 114 days-116 days 4 165.3 mmHg 4.6 9.2 intra-aortic abdominal radiotelemetry 86400 0 65067 283
SS.SR-(D3Arb14-D3Mco36)/Mco plasma urea nitrogen level controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. blood urea nitrogen amount male 114 days-118 days 6 9.3 mmol/l 0.7 1.71 plasma urea nitrogen analysis 0 0 65089 283
SS/Jr plasma glucose level controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. blood glucose amount male 114 days-118 days 4 142.2 mg/dl 19.8 39.6 blood glucose analysis 0 0 65092 283
SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. body mass male 114 days-118 days 6 384.2 g 7.3 17.88 body weighing method 0 0 65098 283
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 386.33 beats/min 5.84 10.12 radiotelemetry carotid artery 0 - 67117 717
SS-Ncf2em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 5 356.4 beats/min 6.38 14.28 radiotelemetry carotid artery 0 - 67135 717
SS-Gpr183em2Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 379.0 beats/min 13.0 18.38 radiotelemetry carotid artery 0 - 67134 717
FHH-Chr 1BN-Sorcs1em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 7 363.0 beats/min 22.2 58.73 radiotelemetry carotid artery 0 - 67136 717
SS-Nckap5em2Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 351.0 beats/min 18.0 25.46 radiotelemetry carotid artery 0 - 67151 717
SS-Gpr183em3Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 361.5 beats/min 12.22 24.45 radiotelemetry carotid artery 0 - 67147 717
SS-Alms1em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 358.0 beats/min radiotelemetry carotid artery 0 - 67156 717
SS-Rag1em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 354.0 beats/min 13.83 27.65 radiotelemetry carotid artery 0 - 67154 717
SS-Bcas3em4Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 391.0 beats/min radiotelemetry carotid artery 0 - 67162 717
SS-Nckap5em3Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 362.33 beats/min 27.96 48.43 radiotelemetry carotid artery 0 - 67169 717
SS-Itga9em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 375.25 beats/min 16.68 33.36 radiotelemetry carotid artery 0 - 67167 717
F344/DuCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 7 1.34 ml/min 0.23 0.62 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51684 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 15.4 beats/min 7.93 19.42 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51694 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 -74.95 beats/min 19.95 39.89 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51701 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 -64.96 beats/min 12.05 45.09 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51708 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 15 -4.99 beats/min 8.54 33.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51719 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 10.79 beats/min 17.8 35.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51723 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 8.33 beats/min 25.63 62.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51728 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 14.83 mmHg 6.29 12.58 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51736 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 14.06 mmHg 2.07 2.92 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51738 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 115.62 mmHg 3.34 4.72 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51744 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 126.47 mmHg 2.33 6.16 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51745 481
GH/OmrMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 8 15.69 mg/d 3.09 8.73 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51756 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 10 19.71 mg/d 4.56 14.41 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51762 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 10 10.61 mg/d 1.41 4.46 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51761 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 27.25 mmHg 4.3 9.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51770 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 21.82 mmHg 4.54 12.02 vascular fluid filled catheter 0 51784 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 22.37 mmHg 3.79 9.28 vascular fluid filled catheter 0 51787 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 14 1.94 ml/min 0.2 0.73 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51797 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 15.53 beats/min 17.94 50.74 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51795 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 2 1.65 ml/min 0.23 0.32 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51804 481
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.33 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51808 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 24.8 mmHg 0.3 0.42 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51815 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 28.68 mmHg 3.5 7.83 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51817 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 18 135.0 mmHg 5.04 21.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51821 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 129.19 mmHg 3.08 7.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51822 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 127.98 mmHg 2.2 6.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51825 481
GH/OmrMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 146.56 mmHg 2.45 6.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51827 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 5 8.51 ng/ml/h 2.42 5.42 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51832 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 3 0.84 ng/ml/h 0.08 0.14 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51836 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 6 1.23 ng/ml/h 0.27 0.66 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51838 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 0.65 ng/ml/h 0.25 0.6 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51841 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 -26.49 beats/min 16.87 44.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51849 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 22.21 beats/min 6.03 17.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51855 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 21.95 mmHg 2.41 6.38 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51861 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 21.98 mmHg 3.61 10.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51862 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 1 31.77 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51868 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 3.0 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51866 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 19 11.47 mEq/d 0.98 4.28 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51882 481
LEW/Crl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 103.93 mmHg 3.0 7.95 vascular fluid filled catheter 0 51879 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 115.67 mmHg 1.6 4.24 vascular fluid filled catheter 0 51880 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 10 10.9 mEq/d 0.8 2.54 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51894 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 9 0.22 mg/dl 0.01 0.03 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51898 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51896 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.31 mg/dl 0.02 0.04 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51902 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.3 mg/dl 0.01 0.02 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51904 481
LEW/Crl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 105.63 mmHg 1.68 5.03 vascular fluid filled catheter 0 51908 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -0.2 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51919 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 18.8 mmHg vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51913 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 -3.32 beats/min 20.7 62.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51918 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 6 1.5 ml/min 0.11 0.27 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51930 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 7 1.61 ml/min 0.15 0.38 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51932 481
Hsd:SD urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 15 15.59 mEq/d 0.52 2.03 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51941 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 3 1.49 ml/min 0.16 0.28 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51955 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 24.43 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51965 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 13.53 mmHg 3.99 10.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51969 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 4 8.94 mmHg 2.68 5.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51971 481
SS-Chr 20BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 13 124.79 mmHg 2.58 9.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51998 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 156.06 mmHg 6.95 17.02 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52002 481
GH/OmrMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 160.79 mmHg 5.64 16.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51999 481
SS-Chr 20BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 122.5 mmHg 2.84 10.64 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52006 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 20 9.28 mEq/d 1.19 5.33 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 52012 481
SS-Chr 16BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 6 14.22 mEq/d 0.96 2.35 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 52013 481
LEW/Crl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 394.18 beats/min 3.77 9.98 vascular fluid filled catheter 0 52032 481
WKY/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 0.94 ml/min 0.17 0.39 urine creatinine analysis 0 52030 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.27 mg/dl 0.0 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52037 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.35 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52038 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.27 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52046 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -11.07 beats/min 14.76 36.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 52056 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -25.42 beats/min 8.98 26.95 vascular fluid filled catheter 0 52076 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 125.91 mmHg 2.56 3.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52085 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 136.28 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52086 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 133.43 mmHg 3.83 10.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52090 481
FHH-Chr 15BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 9 232.75 mg/d 44.36 133.08 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52095 482
FHH-Chr 3BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 2 259.8 mg/d 89.85 127.07 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52099 482
FHH-Chr 5BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 6 110.21 mg/d 29.1 71.27 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52100 482
FHH-Chr 6BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 11 409.4 mg/d 67.83 224.98 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52103 482
FHH-Chr 6BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 8 162.2 mg/d 70.89 200.51 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52105 482
FHH-Chr 10BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 9 343.27 mg/d 52.78 158.34 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52121 482
FHH-Chr 7BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 13 379.56 mg/d 75.35 271.67 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52138 482
SS-Chr 17BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 5 2.41 ml/min 0.57 1.27 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52151 482
SS-Chr 17BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 5 3.45 ml/min 1.21 2.69 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52153 482
FHH-Chr 12BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 11 14.16 mEq/d 1.75 5.8 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52799 482
FHH-Chr 10BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 9 19.48 mEq/d 1.49 4.46 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52807 482
FHH-Chr 4BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 9 14.41 mEq/d 2.04 6.13 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52813 482
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 11 15.99 mEq/d 2.14 7.08 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52821 482
FHH-Chr 7BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 11 14.23 mEq/d 3.75 12.43 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52824 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 10 190.68 mmHg 5.29 16.74 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52830 482
SS-Chr 10BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 10 171.08 mmHg 6.65 21.04 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52829 482
SS-Chr 6BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 9 160.76 mmHg 6.88 20.63 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52832 482
SS-Chr 6BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 10 176.2 mmHg 5.38 17.0 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52837 482
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 8 135.4 mmHg 3.37 9.54 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52846 482
SS-Chr 20BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 7 147.43 mmHg 7.77 20.57 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52853 482
SS-Chr YBN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 15 163.31 mmHg 4.36 16.88 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52857 482
SS-Chr 1BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 14 130.52 mmHg 1.16 4.35 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52860 482
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 7 162.57 mmHg 8.34 22.07 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52868 482
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 20 156.0 mmHg 7.15 31.98 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52872 482
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 18 112.49 mmHg 2.77 11.74 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52875 482
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 174.74 mmHg 5.35 16.04 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52877 482
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 110.84 mmHg 1.12 3.36 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52874 482
FHH-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 1 1.17 ng/ml/h radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52883 482
FHH-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 0.4 ng/ml/h 0.07 0.16 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52885 482
FHH-Chr 5BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 1.16 ng/ml/h 0.33 0.88 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52890 482
FHH-Chr XBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 6 2.25 ng/ml/h 0.51 1.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52913 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 1.61 ng/ml/h 0.88 2.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52919 482
FHH-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 2.48 ng/ml/h 0.69 1.38 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52921 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 12 1.33 mEq/d 0.07 0.25 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52928 482
SS-Chr 9BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 1.44 mEq/d 0.12 0.39 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52931 482
SS-Chr 17BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 9 1.49 mEq/d 0.07 0.22 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52937 482
SS-Chr 15BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 7 1.97 mEq/d 0.89 2.35 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52945 482
SS-Chr 3BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 9 1.14 mEq/d 0.14 0.41 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52947 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 1.47 mEq/d 0.11 0.36 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52972 482
SS-Chr 13BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 18 1.39 ml/min 0.09 0.38 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52163 482
SS-Chr 20BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 7 2.03 ml/min 0.27 0.71 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52165 482
SS-Chr 12BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 3 2.21 ml/min 0.03 0.06 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52185 482
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.33 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52223 482
SS-Chr 4BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.34 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52225 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 15 0.35 mg/dl 0.02 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52236 482
FHH-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52244 482
LE/BluGill plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 9 0.33 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52239 482
FHH-Chr 5BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.32 mg/dl 0.03 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52249 482
FHH-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.24 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52258 482
FHH-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 6 0.49 mg/dl 0.1 0.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52271 482
FHH-Chr 17BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.61 mg/dl 0.09 0.21 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52274 482
FHH-Chr 4BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.4 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52276 482
FHH-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 3 0.31 mg/dl 0.05 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52277 482
FHH-Chr 10BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.46 mg/dl 0.04 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52282 482
FHH-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.39 mg/dl 0.05 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52286 482
FHH-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.43 mg/dl 0.04 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52288 482
FHH-Chr 7BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.51 mg/dl 0.05 0.14 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52287 482
FHH-Chr 15BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 9 1.44 mEq/d 0.05 0.16 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52293 482
FHH-Chr 14BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 6 2.0 mEq/d 0.31 0.75 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52300 482
FHH-Chr 8BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 4 1.17 mEq/d 0.1 0.2 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52305 482
FHH-Chr 13BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 0.91 mEq/d 0.11 0.34 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52308 482
FHH-Chr 2BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 5 1.34 mEq/d 0.07 0.15 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52318 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 11 0.77 mEq/d 0.09 0.29 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52333 482
FHH-Chr 2BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 5 1.71 ml/min 0.2 0.44 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52346 482
FHH-Chr 14BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 4 1.09 ml/min 0.1 0.21 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52347 482
FHH-Chr 5BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 7 1.6 ml/min 0.12 0.32 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52351 482
FHH-Chr 13BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 10 1.17 ml/min 0.23 0.73 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52355 482
FHH-Chr 17BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 6 0.89 ml/min 0.26 0.64 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52370 482
FHH-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 73.05 mg/d 23.6 70.81 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52387 482
FHH-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 24.31 mg/d 6.0 15.88 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52393 482
FHH-Chr 19BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 31.83 mg/d 11.92 33.71 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52396 482
FHH-Chr XBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 204.89 mg/d 18.57 49.14 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52421 482
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 0.29 ng/ml/h 0.04 0.13 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52439 482
SS-Chr 10BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 3.82 ng/ml/h 0.85 2.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52444 482
SS-Chr 5BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 0.44 ng/ml/h 0.08 0.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52448 482
SS-Chr 7BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.51 ng/ml/h 0.12 0.37 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52446 482
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 1.66 ng/ml/h 0.38 1.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52451 482
SS-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 0.42 ng/ml/h 0.07 0.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52455 482
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.75 ng/ml/h 0.15 0.45 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52464 482
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 55 0.68 ng/ml/h 0.12 0.9 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52465 482
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 1.04 ng/ml/h 0.18 0.51 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52468 482
SS-Chr 1BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 14 0.67 ng/ml/h 0.2 0.76 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52469 482
SS-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 10 0.99 ng/ml/h 0.13 0.43 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52477 482
SS-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 0.88 ng/ml/h 0.15 0.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52479 482
FHH-Chr 6BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 411.53 beats/min 7.04 21.12 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52493 482
FHH-Chr 19BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 6 434.17 beats/min 11.32 27.72 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52494 482
FHH-Chr 20BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 7 386.33 beats/min 10.29 27.22 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52499 482
FHH-Chr 20BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 6 439.71 beats/min 5.33 13.06 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52502 482
FHH-Chr 14BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 8 405.62 beats/min 14.94 42.25 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52508 482
FHH-Chr 15BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 7 396.79 beats/min 11.52 30.48 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52506 482
FHH/EurMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 48 431.04 beats/min 4.26 29.51 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52505 482
FHH-Chr 10BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 7 443.07 beats/min 4.2 11.1 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52511 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 8 349.72 beats/min 7.76 21.94 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52524 482
FHH-Chr 16BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 8 414.64 beats/min 10.79 30.52 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52529 482
FHH-Chr 14BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 6 156.03 mmHg 5.11 12.52 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52539 482
FHH-Chr 20BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 7 148.57 mmHg 5.32 14.08 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52546 482
SS-Chr 10BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 11 85.48 mg/d 21.9 72.63 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52580 482
SS-Chr 5BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 11.82 mg/d 2.27 6.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52593 482
SS-Chr 9BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 24.49 mg/d 5.25 15.74 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52587 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 16 10.59 mg/d 2.08 8.32 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52606 482
SS-Chr XBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 49.97 mg/d 10.84 28.67 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52612 482
SS.BN-(D8Rat163-D8Rat81)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 13 9.97 mg/d 1.58 5.68 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52617 482
SS-Chr 9BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 8 418.44 beats/min 6.84 19.34 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52638 482
SS-Chr 6BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 10 427.88 beats/min 12.27 38.8 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52639 482
SS-Chr 17BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 404.73 beats/min 7.16 21.49 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52641 482
SS-Chr 3BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 408.25 beats/min 5.72 17.16 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52651 482
SS-Chr 1BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 14 411.34 beats/min 5.76 21.55 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52662 482
SS/JrHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 59 400.39 beats/min 4.05 31.09 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52661 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 10 406.58 beats/min 6.69 21.14 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52664 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 8 407.55 beats/min 8.67 24.52 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52660 482
SS-Chr 4BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 7 399.08 beats/min 14.32 37.89 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52666 482
SS-Chr 19BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 6 384.16 beats/min 17.74 43.46 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52671 482
SS-Chr 12BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 6 379.27 beats/min 8.81 21.58 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52675 482
SS-Chr 9BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 10 170.39 mg/d 23.75 75.12 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52684 482
SS-Chr 17BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 7 288.64 mg/d 67.49 178.56 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52692 482
SS-Chr 13BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 20 63.79 mg/d 6.53 29.18 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52702 482
SS-Chr 3BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 7 95.55 mg/d 11.55 30.56 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52703 482
SS-Chr YBN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 17 152.58 mg/d 15.5 63.93 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52708 482
SS-Chr 11BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 19 87.31 mg/d 7.52 32.76 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52705 482
SS-Chr 4BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 8 62.33 mg/d 6.17 17.45 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52721 482
SS-Chr XBN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 6 270.3 mg/d 64.55 158.12 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52727 482
SS-Chr 14BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 11 11.05 mEq/d 2.27 7.51 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52733 482
SS-Chr 13BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 16 11.92 mEq/d 1.33 5.31 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52757 482
SS-Chr 1BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 19 10.57 mEq/d 1.46 6.38 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52765 482
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 9 12.51 mEq/d 0.99 2.97 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52760 482
SS-Chr 20BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 9 15.96 mEq/d 2.07 6.2 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52755 482
SS-Chr 4BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 7 15.25 mEq/d 2.49 6.59 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52766 482
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 20.6 beats/min 13.45 26.91 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50513 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 17 406.36 beats/min 7.25 29.89 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50523 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 356.76 beats/min 13.66 40.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50528 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 8 423.68 beats/min 13.94 39.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50531 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 6 7.97 ng/ml/h 1.02 2.5 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50541 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 3.0 mmHg 3.86 7.72 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50542 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 9.34 beats/min 8.51 25.54 vascular fluid filled catheter 0 50552 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 2 1.95 ng/ml/h 0.95 1.34 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50566 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 6 2.26 ng/ml/h 0.6 1.47 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50570 481
LEW/Crl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 1.83 ml/min 0.27 0.53 urine creatinine analysis 0 50574 481
LEW/Crl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 6 1.17 ml/min 0.1 0.25 urine creatinine analysis 0 50573 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 410.92 beats/min 6.97 20.92 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50577 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 -34.01 beats/min 27.27 81.82 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50580 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -47.96 beats/min 18.32 51.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50589 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 -24.45 beats/min 31.16 62.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50590 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 2.83 mmHg 1.4 4.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50598 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -52.77 beats/min 23.98 67.84 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50597 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 12 3.2 mmHg 1.6 5.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50603 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 1.29 mmHg 2.0 4.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50607 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 -25.11 mmHg 3.07 8.68 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50631 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 133.26 mmHg 2.16 5.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50641 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 136.5 mmHg 3.86 12.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50644 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 45.88 mmHg 2.54 7.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50661 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 411.76 beats/min 26.24 52.48 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50667 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 39.82 mmHg 2.4 6.8 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50665 481
SS-Chr 16BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 387.4 beats/min 19.95 52.79 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50670 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 3 118.36 mmHg 3.5 6.07 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50673 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 129.46 mmHg 0.32 0.45 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50675 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -5.23 beats/min 21.31 56.37 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50686 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 9 0.32 mg/dl 0.01 0.04 radioimmunoassay 0 50690 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 2.83 beats/min 19.88 56.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50687 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -0.89 mmHg 3.73 9.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50698 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 0.72 mmHg 2.7 7.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50706 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 9 0.76 ng/ml/h 0.14 0.41 radioimmunoassay 0 50712 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 12 -31.9 beats/min 21.48 74.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50721 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -27.44 beats/min 13.68 36.19 vascular fluid filled catheter 0 50729 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 18 144.0 mmHg 3.04 12.89 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50734 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 8 -25.21 beats/min 19.43 54.97 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50728 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 101.3 mmHg 2.17 6.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50745 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 173.36 mmHg 5.88 16.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50739 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 32.74 mmHg 4.09 9.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50748 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 30.25 mmHg 4.03 12.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50753 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 27.55 mmHg 4.09 11.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50757 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 -8.98 mmHg 4.38 9.8 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50762 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 4.89 mmHg 4.16 11.0 vascular fluid filled catheter 0 50769 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 24.53 mmHg 3.8 11.4 vascular fluid filled catheter 0 50768 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 -0.91 mmHg 3.29 9.86 vascular fluid filled catheter 0 50770 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 0.93 mmHg 2.33 6.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50780 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 124.3 mmHg 1.8 4.42 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50793 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 16.67 beats/min 10.47 39.18 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50791 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 15 -12.57 mmHg 1.76 6.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50801 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 -11.35 mmHg 4.78 14.34 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50803 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 -3.43 mmHg 1.25 2.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50804 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 -7.15 mmHg 2.83 6.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50812 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 20 30.61 mmHg 1.78 7.98 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50826 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -6.9 beats/min 15.96 47.88 vascular fluid filled catheter 0 50834 481
LEW/Crl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 96.06 mmHg 2.3 4.61 vascular fluid filled catheter 0 50838 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 394.6 beats/min 13.13 26.26 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50861 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 4 16.23 mmHg 3.7 7.41 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50859 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 11.78 mmHg 2.52 5.04 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50857 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 -48.95 beats/min 23.61 47.22 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50865 481
GH/OmrMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 419.89 beats/min 5.87 17.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50880 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 34.12 mmHg 1.84 2.6 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50900 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 28.03 mmHg 6.24 13.95 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50901 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 3 43.55 mmHg 0.46 0.79 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50898 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 17 383.46 beats/min 6.17 25.44 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50923 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 3.68 mmHg 1.76 3.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50928 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 131.22 mmHg 4.62 11.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50942 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 137.12 mmHg 4.62 13.86 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50947 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 394.94 beats/min 8.93 33.43 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50956 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 28.71 mmHg 4.76 12.59 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50967 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 33.35 mmHg 3.43 9.71 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50973 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 13 25.74 beats/min 10.93 39.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50978 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 36.95 beats/min 7.33 14.67 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50987 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 4.14 mmHg 2.16 4.83 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50992 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 4.37 mmHg 1.82 5.15 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50995 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 -2.5 mmHg 2.9 7.67 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50997 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 11.67 mmHg 1.81 5.73 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51024 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 -0.58 mmHg 2.12 5.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51029 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 7.32 mmHg 3.21 6.42 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51030 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 33.82 mmHg 2.59 10.04 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51033 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -55.8 beats/min 16.75 44.32 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51035 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 -1.55 mmHg 1.88 3.77 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51081 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 0.65 mmHg 2.07 5.48 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51084 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 21.46 beats/min 11.94 37.77 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51091 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -6.87 beats/min 2.38 6.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51092 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 0.56 beats/min 2.95 8.35 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51094 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 407.56 beats/min 12.77 38.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51112 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 0.6 mmHg 0.68 1.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51111 481
SS-Chr 16BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 12 394.2 beats/min 10.18 35.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51117 481
GH/OmrMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 390.4 beats/min 15.58 41.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51120 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 15.03 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51128 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 4 8.88 mmHg 3.75 7.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51137 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 145.23 mmHg 3.65 10.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51146 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 129.62 mmHg 2.92 8.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51150 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -15.83 beats/min 10.21 27.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51160 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51173 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 14.94 mmHg 4.87 11.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51194 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 18.33 mmHg 3.71 10.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51196 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 10.97 beats/min 9.95 24.37 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51202 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 -34.17 beats/min 7.73 24.44 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51203 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -25.02 beats/min 12.07 26.99 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51213 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -22.91 beats/min 7.09 10.03 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51214 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -9.45 beats/min 15.69 44.36 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51216 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 15 10.55 beats/min 16.42 63.61 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51233 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 15 -15.78 beats/min 13.94 54.0 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51238 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 10 407.56 beats/min 6.03 19.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51250 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 18.95 beats/min 7.34 17.98 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51260 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 20 1.46 mEq/d 0.2 0.9 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51266 481
SS-Chr 16BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 6 1.4 mEq/d 0.14 0.34 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51267 481
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 11 0.32 mg/dl 0.03 0.11 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51277 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 408.04 beats/min 7.45 21.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51291 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 5 9.79 mEq/d 1.85 4.14 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51294 481
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 121.87 mmHg 1.99 7.45 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51300 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 2 50.5 beats/min 43.3 61.24 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51308 481
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 11 0.32 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51311 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 3 0.3 mg/dl 0.02 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51322 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 133.34 mmHg 4.01 10.6 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51325 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -7.69 beats/min 11.36 30.07 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51331 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 19.93 mmHg 2.87 9.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51340 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 20.68 mmHg 2.71 8.13 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51347 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 15 -27.23 beats/min 9.2 35.65 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51350 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 -35.62 beats/min 11.0 33.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51357 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -19.96 beats/min 18.9 50.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51360 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 109.0 mmHg 4.18 8.37 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51390 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 2.21 mmHg 3.42 9.04 vascular fluid filled catheter 0 51395 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 8.24 beats/min 8.8 32.91 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51401 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 16.77 mmHg 3.57 9.46 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51417 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 10.13 mmHg 4.49 10.03 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51415 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 2.2 beats/min 15.19 40.18 vascular fluid filled catheter 0 51412 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 41.75 mmHg 2.35 7.05 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51426 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 39.47 mmHg 5.6 11.2 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51431 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 30.72 mmHg 3.16 8.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51429 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 4 19.43 mg/d 3.2 6.4 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51437 481
GH/OmrMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 9 40.1 mg/d 4.15 12.45 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51442 481
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 8 10.1 mg/d 2.04 5.77 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51460 481
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 21 14.0 mg/d 3.02 13.86 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51466 481
SS-Chr 20BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 19 6.82 mg/d 0.97 4.22 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51467 481
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 7 1.94 mg/d 0.47 1.24 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51476 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 10 0.44 mg/d 0.07 0.22 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51477 481
SS-Chr 20BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 18 12.74 mg/d 2.79 11.82 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51475 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 386.26 beats/min 6.07 14.87 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51481 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 10 0.31 mg/d 0.05 0.17 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51478 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 18.91 mmHg 2.36 9.14 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51480 481
SS-Chr 16BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 402.6 beats/min 5.87 13.12 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51484 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 20.44 mmHg 5.29 11.82 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51490 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 3 9.52 mmHg 0.72 1.24 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51495 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 -28.06 beats/min 17.7 46.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51504 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -81.81 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51505 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 -41.61 beats/min 8.9 28.13 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51507 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 3.18 beats/min 9.27 26.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51510 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 12 -46.0 beats/min 14.52 50.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51509 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -22.2 beats/min 16.32 46.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51512 481
SS-Chr 9BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 16 1.32 mEq/d 0.12 0.49 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51523 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 5 0.8 mEq/d 0.21 0.46 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51526 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -48.94 beats/min 12.72 33.65 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51530 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 6 1.92 ml/min 0.12 0.28 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51540 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 7 1.08 ml/min 0.08 0.2 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51544 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 9 2.23 ml/min 0.08 0.25 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51547 481
FHH/EurMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 8 59.56 mg/d 16.55 46.8 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51558 481
SS-Chr 16BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 8 12.87 mg/d 2.1 5.94 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51562 481
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 11 17.56 mg/d 3.43 11.37 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51567 481
GH/OmrMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 9 1.63 mg/d 0.26 0.77 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51568 481
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 10 12.24 mg/d 2.4 7.59 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51570 481
SS-Chr 16BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 365.3 beats/min 2.73 8.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51581 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 8 361.82 beats/min 5.01 14.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51585 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 5.23 mmHg 1.96 5.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51589 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 8 2.16 ng/ml/h 0.24 0.68 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51606 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -19.53 beats/min 25.96 63.58 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51609 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 131.21 mmHg 4.02 8.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51629 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.26 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51647 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 10 0.33 mg/dl 0.03 0.08 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51646 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.31 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51650 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 23.04 mmHg 2.89 8.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51666 481
F344/DuCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 10 0.7 mg/d 0.25 0.8 automated urine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51672 481
Crl:CD(SD) urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 9 0.59 mg/d 0.08 0.25 automated urine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51669 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 4.15 beats/min 23.97 47.94 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51673 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 26.33 mmHg 3.02 7.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51668 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 20 405.19 beats/min 8.56 38.28 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51677 481
SS-Chr 9BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 414.38 beats/min 10.05 30.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50321 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 8.4 beats/min vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51676 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -91.71 beats/min 8.29 11.72 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50346 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 -71.27 beats/min 21.14 42.27 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50344 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 9 0.4 mg/dl 0.02 0.06 radioimmunoassay 0 50409 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 12 -47.58 beats/min 14.04 48.64 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50424 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 8 -8.48 beats/min 15.29 43.23 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50429 481
WKY/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 8 16.23 mg/d 3.74 10.59 automated urine analysis 0 50443 481
WKY/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 9 21.67 mg/d 3.9 11.7 automated urine analysis 0 50440 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 3 356.33 beats/min 4.7 8.14 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50445 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 14 0.93 ng/ml/h 0.15 0.56 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50456 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 7 0.83 ng/ml/h 0.23 0.6 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50464 481
LEW/Crl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 8 0.56 mg/d 0.12 0.34 automated urine analysis 0 50467 481
SS-Chr 9BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 414.07 beats/min 11.47 28.11 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50478 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 8.67 mmHg 1.66 6.43 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50499 481
LEW both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 6 7.91 g/kg 0.09 0.22 post excision weight measurement 0 0 64771 226
SS-Chr 5BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 7 368.73 beats/min 6.96 18.42 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52646 482
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 1 23.0 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50508 481
SS.LEW-(D16Got3-D16Rat112)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 9 10.1 g/kg 0.2 0.6 post excision weight measurement 0 0 64780 226
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -24.77 beats/min 14.96 44.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50512 481
SS.LEW-(D10Chm128-D10Chm169)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 8 10.0 g/kg 0.3 0.85 post excision weight measurement 0 0 64783 226
SS.LEW-(D10Rat24-Igfbp4)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 5 10.0 g/kg 0.4 0.89 post excision weight measurement 0 0 64786 226
SS.LEW-(D8Chm14-D8Rat16)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 7 9.5 g/kg 0.2 0.53 post excision weight measurement 0 0 64789 226
SS.LEW-(D2Rat199-D2Mco17)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 8 11.4 g/kg 0.6 1.7 post excision weight measurement 0 0 64799 226
SS.MNS-(D2Chm25-D2Rat131)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 5 2.85 mg/g 0.09 0.2 post excision weight measurement 0 0 64958 226
SS.LEW-(D2Rat199-D2Mco17)/Ayd heart right ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart right ventricle mass male 98 days 8 0.7 mg/g 0.03 0.08 post excision weight measurement 0 0 64963 226
SS.LEW-(D2Rat18-D2Chm277)/Ayd heart right ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart right ventricle mass male 98 days 6 0.66 mg/g 0.02 0.05 post excision weight measurement 0 0 64965 226
SS.BN-(D13Rat151-D13Rat197)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 49.3 mg/d 3.7 12.82 urine analysis 86400 0 65249 15
SS/Jr body weight controlled sodium content diet (4 %) (for 28 days) Garrett MR, et al., Physiol Genomics 2000 Jun 29;3(1):33-8. body mass male 53 days-81 days 10 344.0 g 5.1 16.13 body weighing method 0 0 66109 691
SS.SR-(D3Mco78-D3Got130)/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 20 serial mean 209.1 mmHg 4.8 21.47 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65799 237
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 24 days) Rapp JP, et al., Genomics 1998 Jul 15;51(2):191-6 heart mass male 62 days 20 1.36 g 0.01 0.06 post excision weight measurement 0 0 65834 633
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. total urine protein amount female 90 days-94 days 20 8.6 mg/d 2.2 9.84 urine total protein analysis 0 0 66151 151
SS.BN-(D13Rat111-D13Got22)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 45.0 mg/d 16.7 57.85 urine analysis 86400 0 65210 15
SS.BN-(D13Rat20-D13Got22)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 76.6 mg/d 14.8 51.27 urine analysis 86400 0 65213 15
SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84 days-88 days 12 30.5 mg/d 6.3 21.82 urine analysis 86400 0 65219 15
SS.BN-(D13Rat115-D13Rat61)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 45.4 mg/d 6.5 22.52 urine analysis 86400 0 65221 15
SS.BN-(D13Rat91-D13Rat179)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84 days-88 days 12 45.9 mg/d 6.6 22.86 urine analysis 86400 0 65227 15
SS.BN-(D13Rat91-D13Got45)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84 days-88 days 12 43.6 mg/d 4.1 14.2 urine analysis 86400 0 65224 15
SS.BN-(D13Rat101-D13Rat46)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84 days-88 days 12 29.2 mg/d 5.4 18.71 urine analysis 86400 0 65235 15
SS.BN-(D13Rat57-D13Rat192)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 62.8 mg/d 3.9 13.51 urine analysis 86400 0 65246 15
SS.BN-(D13Rat57-D13Rat192)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84 days-88 days 12 50.8 mg/d 7.7 26.67 urine analysis 86400 0 65247 15
SS.LEW-(D3Chm64-D3Rat17)/Ayd diastolic blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 42 days) Palijan A, et al., Physiol Genomics 2003 Sep 29;15(1):1-8. arterial blood pressure trait male 66 days-77 days 8 measurement taken every 4 hours during a 24-hour period serial mean 167.0 mmHg 9.0 25.46 radiotelemetry 86400.0 0 65557 615
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 42 days) Palijan A, et al., Physiol Genomics 2003 Sep 29;15(1):1-8. arterial blood pressure trait male 66 days-77 days 15 measurement taken every 4 hours during a 24-hour period serial mean 175.0 mmHg 3.0 11.62 radiotelemetry 86400.0 0 65559 615
SS.LEW-(D3Mco21-D3Rat17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 42 days) Palijan A, et al., Physiol Genomics 2003 Sep 29;15(1):1-8. arterial blood pressure trait male 66 days-77 days 6 measurement taken every 4 hours during a 24-hour period serial mean 166.0 mmHg 9.0 22.05 radiotelemetry 86400.0 0 65565 615
SS.BN-(D13Rat111-D13Got22)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait female 86 days-89 days 12 152.0 mmHg 4.4 15.24 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 5397 15
SS.BN-(D13Rat57-D13Rat192)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 181.0 mmHg 2.7 9.35 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 5402 15
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait female 86 days-89 days 12 177.0 mmHg 5.0 17.32 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 5405 15
SS.LEW-(D5Mit9-D5Mco10)/Jr body weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass not specified 64 days-71 days 40 282.0 g 1.8 11.38 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64717 222
SS/Jr heart left ventricle end-systolic diameter controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 29 days) then controlled sodium content diet (4 %) (between 40 and 41 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart left ventricle end-systolic diameter male 109 days-112 days 6 4.2 mm 0.4 0.98 transthoracic echocardiography 0 0 65745 283
SS.SR-(D3Arb14-D3Mco36)/Mco heart left ventricle fractional shortening controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 29 days) then controlled sodium content diet (4 %) (between 40 and 41 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart left ventricle end-diastolic diameter male 109 days-112 days 7 54.0 % 3.0 7.94 transthoracic echocardiography 0 0 65750 283
LEW/Crl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 %change=VE during7-9 min hypoxia/control during standard conditions 133.06 % 6.62 29.59 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17339 381
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during7-9 min hypoxia/control during standard conditions 128.94 % 5.94 25.2 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17341 381
SS/JrSeac body weight controlled sodium content diet (0.3 %) (for 35 days) Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. body mass not specified 77 days 5 247.0 g 7.6 17.0 body weighing method 0.0 0 67253 733
SS/JrSeac heart left ventricle wet weight controlled sodium content diet (0.3 %) (for 35 days) Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. heart left ventricle mass not specified 77 days 5 1.0 g 0.09 0.2 post excision weight measurement 0.0 0 67257 733
SS/HsdMcwiCrl absolute change in mean arterial blood pressure controlled sodium content diet (0.15 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1. arterial blood pressure trait male 35 days-56 days 0 -28.0 mmHg 4.0 tail cuff plethysmography 0.0 0 DR strain is from Charles River Laboratory, Wilmington, MA 67262 731
SR/Hsd absolute change in mean arterial blood pressure controlled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1. arterial blood pressure trait male 35 days-56 days 0 7.0 mmHg 1.0 tail cuff plethysmography 0.0 0 DR strain is from Charles River Laboratory, Wilmington, MA 67269 731
BN/NHsdMcwi heart left ventricle wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart left ventricle mass female 97 days-101 days 22 0.45 g 0.01 0.05 post excision weight measurement 0.0 0 67297 151
SS/JrHsdMcwi plasma total cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood cholesterol amount female 92 days-94 days 12 76.0 mg/dl 4.4 15.24 plasma total cholesterol measurement test 0.0 0 67290 151
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 34.0 mmHg 3.0 10.82 vascular indwelling catheter method left femoral artery 0.0 0 67300 151
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 20 serial mean 210.6 mmHg 3.4 15.21 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65792 237
SS.SR-(Cyp11b1)/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 7 days) then controlled sodium content diet (4 %) (for 24 days) Cicila GT, et al., Mamm Genome 1997 Dec;8(12):896-902. arterial blood pressure trait female 61 days 12 serial mean 215.5 mmHg 8.5 29.44 tail cuff plethysmography 0 11794 146
SS.SR-(D7Rat16-D7Mgh5)/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. arterial blood pressure trait male 68 days-70 days 20 serial mean 210.5 mmHg 2.8 12.52 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11796 147
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 20 298.2 g 4.2 18.78 body weighing method 0 11799 147
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. heart mass male 68 days-70 days 20 1.22 g 0.02 0.08 post excision weight measurement 0 11797 147
SS.SR-(D7Rat16-D7Rat189)/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. arterial blood pressure trait male 68 days-70 days 20 serial mean 219.0 mmHg 3.4 15.21 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11802 147
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. heart mass male 68 days-70 days 20 1.25 g 0.02 0.09 post excision weight measurement 0 11809 147
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 20 289.8 g 3.2 14.31 body weighing method 0 11817 147
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. heart mass male 68 days-70 days 20 1.24 g 0.01 0.07 post excision weight measurement 0 11821 147
SS.MNS-(D10Mco14-D10Mit11)/Jr systolic blood pressure controlled sodium content diet (2 %) (between 25 and 28 days) Dukhanina OI, et al., Mamm Genome 1997 Apr;8(4):229-35. arterial blood pressure trait not specified 64 days-68 days 20 serial mean 175.0 mmHg 1.7 7.6 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11832 148
SS.WKY-(D2N35-Mme)/Mco systolic blood pressure controlled sodium content diet (0.2 %) (between 15 and 18 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Rapp JP, et al., J Clin Invest 1998 Apr 15;101(8):1591-5. arterial blood pressure trait male 70 days-76 days 24 serial mean 185.0 mmHg 1.8 8.82 tail cuff plethysmography 0 11846 150
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 95.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11698 119
SS.SR-(D7Rat16-D7Rat189)/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 20 296.3 g 3.0 13.42 body weighing method 0 11806 147
SS.MNS-(D2Chm51-D2Rat341)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 arterial blood pressure trait male 68 days-98 days 8 144.0 mmHg 2.0 5.66 radiotelemetry 30 0 11937 226
SS.LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 arterial blood pressure trait male 68 days-98 days 7 150.0 mmHg 2.0 5.29 radiotelemetry 30 0 11956 226
SS.LEW-(D17Rat65-D17Chm2)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 arterial blood pressure trait male 68 days-98 days 5 171.0 mmHg 8.0 17.89 radiotelemetry 30 0 11963 226
SS.LEW-(D17Chm9-D17Rat97)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 arterial blood pressure trait male 68 days-98 days 10 169.0 mmHg 7.0 22.14 radiotelemetry 30 0 11964 226
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 310.0 g 2.38 body weighing method 0 11976 205
SS.LEW-(D10Mco113-D10Got93)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 337.0 g 2.09 body weighing method 0 11977 205
SS.LEW-(D10Mco84-D10Mco143)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 335.0 g 3.0 body weighing method 0 11979 205
SS.LEW-(D10Mco84-D10Rat58)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 311.0 g 4.21 body weighing method 0 11980 205
SS.LEW-(D10Mco84-D10Mco129)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 308.0 g 5.3 body weighing method 0 11981 205
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-94 days 35 continuous mean 206.0 mmHg 6.0 35.5 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day 11984 229
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.09 g/kg 0.03 0.14 post excision weight measurement 0 11994 221
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-94 days 35 continuous mean 167.0 mmHg 4.0 23.66 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day 12002 229
SS.LEW-(D10Mit10-D10Rat24)/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 3.89 g/kg 0.02 0.09 post excision weight measurement 0 12015 221
SS.MNS-(D10M11Mit119-D10Mit11)/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 3.84 g/kg 0.04 0.19 post excision weight measurement 0 12026 221
SS.MNS-(D10Mco70-D10Mit11)/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.28 g/kg 0.05 0.21 post excision weight measurement 0 12036 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 3.9 g/kg 0.04 post excision weight measurement 0 12039 205
SS.LEW-(D3Got33-D3Chm68)/Ayd body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 10 389.0 g 6.0 18.97 body weighing method 0 0 12042 226
SS.LEW-(D10Mco113-D10Got93)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 3.91 g/kg 0.04 post excision weight measurement 0 12050 205
SS.LEW-(D10Chm10-D10Rat11)/Ayd body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 7 375.0 g 5.0 13.23 body weighing method 0 0 12061 226
SS.LEW-(D10Rat27-Igfbp4)/Ayd body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 7 388.0 g 6.0 15.87 body weighing method 0 0 12058 226
SS.LEW-(D10Chm128-D10Chm169)/Ayd body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 8 369.0 g 6.0 16.97 body weighing method 0 0 12063 226
SS.LEW-(D17Chm14-D17Rat181)/Ayd body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 5 377.0 g 9.0 20.12 body weighing method 0 0 12069 226
SS.LEW-(D18Chm41-D18Rat92)/Ayd body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 5 386.0 g 5.0 11.18 body weighing method 0 0 12076 226
SS.LEW-(D18Chm91-D18Rat67)/Ayd body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 5 389.0 g 8.0 17.89 body weighing method 0 0 12077 226
SS.LEW-(D10Chm224-D10Chm6)/Ayd body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 11 382.0 g 6.0 19.9 body weighing method 0 0 12082 226
SS.MNS-(D2Wox27-Adh1)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 5 3.7 g/kg 0.2 0.45 post excision weight measurement 0 0 12094 226
SS.MNS-(D2Chm25-Fgg)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 9 3.54 g/kg 0.09 0.27 post excision weight measurement 0 0 12096 226
SS.LEW-(D3Mco21-D3Rat17)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 4 3.64 g/kg 0.08 0.16 post excision weight measurement 0 0 12098 226
SS.LEW-(D8Rat56-D8Rat51)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 9 4.7 g/kg 0.4 1.2 post excision weight measurement 0 0 12107 226
SS.MNS-(Adh1-D2Mit5)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 25 and 28 days) Deng AY, et al., Hypertension 1997 Aug;30(2 Pt 1):199-202 arterial blood pressure trait male 65 days-68 days 20 181.1 mmHg 1.9 8.5 tail cuff photoplethysmography tail 0 average of 4 days, 3 to 4 consistent readings each day, IITC 12108 231
SS.LEW-(D18Chm56-D18Rat55)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 5 3.9 g/kg 0.2 0.45 post excision weight measurement 0 0 12123 226
SS.MNS-(D10Mco30-D10Got91)/3Mco systolic blood pressure controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 arterial blood pressure trait male 64 days-68 days 20 193.0 mmHg 3.5 15.65 tail cuff plethysmography tail 345600.0 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 12140 232
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 1.31 g 0.01 0.04 post excision weight measurement 0 0 12154 232
LEW/NCrl systolic blood pressure controlled sodium content diet (0.2 %) (for 168 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 203 days 8 serial mean 131.0 mmHg 3.3 9.33 tail cuff plethysmography tail 0 0 12174 222
LEW/NCrl systolic blood pressure controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 168 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 203 days 8 serial mean 140.0 mmHg 2.5 7.07 tail cuff plethysmography tail 0 0 12178 222
SR/Jr body weight controlled sodium content diet (0.2 %) (for 56 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 91 days 10 313.0 g 4.8 15.18 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12181 222
SR/Jr body weight controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 168 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 203 days 10 407.0 g 5.7 18.02 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12189 222
LEW/NCrl body weight controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 112 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 147 days 8 409.0 g 5.1 14.42 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12199 222
SS.MNS-(D10Mco62-D10Mco30)/Mco heart wet weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 1.37 g 0.03 0.13 post excision weight measurement 0 0 12205 232
SS.MNS-(D10Mco30-D10Got91)/1Mco heart wet weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 1.21 g 0.02 0.09 post excision weight measurement 0 0 12208 232
SS.MNS-(D10Mco30-D10Got91)/3Mco heart wet weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 1.13 g 0.01 0.04 post excision weight measurement 0 0 12210 232
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 4.08 g/kg 0.05 0.22 post excision weight measurement 0 0 12219 232
SS.MNS-(D10Mco62-D10Got99)/Mco heart weight to body weight ratio controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 4.09 g/kg 0.03 0.13 post excision weight measurement 0 0 12221 232
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. heart mass male 70 days-72 days 20 1.12 g 0.02 0.07 post excision weight measurement 0 12275 237
SS-Tg(ApoC3-CETP)53Opaz plasma total cholesterol level controlled sodium content diet (0.3 %) (for 180 days) then fasting (for 16 hours) Herrera VL, et al., J Hypertens. 2007 Aug;25(8):1608-12 blood cholesterol amount male 180 days 5 577.61 mg/dl 170.66 381.6 plasma total cholesterol measurement test 0 12284 238
SS.SR-(D3Mco78-D3Got130)/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 20 296.3 g 3.0 13.42 body weighing method 0 12288 237
SS.SR-(D3Mco24-D3Got130)/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 19 307.7 g 1.9 8.28 body weighing method 0 12297 237
SS.SR-(D3Mco36-D3Mco46)/Jr both kidneys wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. kidney mass male 70 days-72 days 40 2.83 g 0.04 0.23 post excision weight measurement 0 12309 237
SS-Tg(ApoC3-CETP)53Opaz plasma triglyceride level controlled sodium content diet (0.3 %) (for 180 days) then fasting (for 16 hours) Herrera VL, et al., J Hypertens. 2007 Aug;25(8):1608-12 blood triglyceride amount male 180 days 5 53.43 mmol/l 20.19 45.15 plasma triglyceride analysis 0 \ 12307 238
SS/Jr both kidneys wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. kidney mass male 70 days-72 days 41 3.04 g 0.03 0.19 post excision weight measurement 0 12318 237
SR/Hsd plasma high density lipoprotein cholesterol level controlled sodium content diet (0.3 %) then fasting (for 16 hours) Herrera VL, et al., Circ Res 2004 Mar 5; 94(4):446-52 blood HDL cholesterol amount male 180 days 6 27.8 mg/dl 1.16 2.84 plasma high-density lipoprotein-cholesterol measurement test 0 11892 204
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 arterial blood pressure trait male 64 days-66 days 0 221.0 mmHg 3.95 tail cuff plethysmography 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 11913 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.16 g/kg 0.05 0.21 post excision weight measurement 0 11914 221
SS.LEW-(D10Arb9-D10Got101)/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.22 g 0.01 0.04 digital scale post excision weight measurement 0 0 12681 282
SS.LEW-(D10Mco89-D10Got101)/Mco heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.18 g 0.01 0.05 digital scale post excision weight measurement 0 0 12686 282
SS.LEW-(D10Arb9-D10Got101)/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 20 303.0 g 1.14 5.1 whole body digital scale 0 0 12696 282
SS.LEW-(D10Arb9-D10Mco84)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 20 315.0 g 2.77 12.39 whole body digital scale 0 0 12702 282
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 3.85 g/kg 0.05 0.21 digital scale post excision weight measurement 0 0 12712 282
SS.LEW-(D10Arb9-D10Rat57)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 3.68 g/kg 0.03 0.14 digital scale post excision weight measurement 0 0 12716 282
SS.LEW-(D10Mco30-D10Got107)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 5 serial mean 168.0 mmHg 6.0 13.42 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12738 304
SS.LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 16 serial mean 150.0 mmHg 6.0 24.0 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12741 304
SS.LEW-(D10Mco15-D10Mgh1)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 6 serial mean 180.0 mmHg 6.0 14.7 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12742 304
SS.LEW-(D10Chm10-D10Chm14)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 5 serial mean 168.0 mmHg 6.0 13.42 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12743 304
SS.LEW-(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 8 serial mean 128.0 mmHg 6.0 16.97 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12746 304
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 20 195.0 mmHg 3.27 14.62 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12807 313
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 20 194.0 mmHg 3.38 15.12 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12808 313
SS.LEW-(D1Mco36-D1Rat131)/1Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 20 178.0 mmHg 2.22 9.93 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12817 313
SS.LEW-(D1Mco36-D1Mco77)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 20 184.0 mmHg 3.07 13.73 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12819 313
SS.LEW-(D1Mco99-D1Rat49)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 20 197.0 mmHg 3.99 17.84 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12823 313
SS.SHR-(D9Mco74-D9Rat64)/Mco diastolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 108.0 mmHg 1.32 2.95 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13033 305
SS.SHR-(D9Mco72-D9Mco93)/Mco mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 125.0 mmHg 1.28 2.86 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13038 305
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 20 serial mean 215.0 mmHg 3.72 16.64 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13084 282
SHR/Fub urine albumin excretion rate controlled sodium content diet (0.2 %) Poyan Mehr A, et al., Physiol Genomics 2003 Aug 15;14(3):209-16. urine albumin amount not specified 28 days 11 0.03 mg/d enzyme linked immunosorbent assay urine 0.0 0 rat albumin ELISA 13282 335
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 235.0 mmHg 4.8 21.47 tail cuff plethysmography 0 average of 3-4 consistent readings 12456 266
SS.LEW-(D1Mco38-D1Rat49)/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 181.0 mmHg 3.03 13.55 tail cuff plethysmography 0 average of 3-4 consistent readings 12464 266
SS.LEW-(D1Rat35-D1Rat49)/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 195.0 mmHg 2.87 12.84 tail cuff plethysmography 0 average of 3-4 consistent readings 12462 266
SS.LEW-(D17Rat65-Prl)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 43 and 47 days) Grondin M, et al., Physiol Genomics 2005 Mar 21;21(1):112-6. Epub 2005 Jan 4. arterial blood pressure trait male 88 days-92 days 5 139.0 mmHg 5.0 11.18 intra-aortic abdominal radiotelemetry 0 measure every 2 min for 24 hrs 12466 261
SS.LEW-(D1Uia8-D1Mco38)/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 205.0 mmHg 1.76 7.87 tail cuff plethysmography 0 average of 3-4 consistent readings 12470 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 314.0 g 1.72 7.69 body weighing method 0 12486 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 308.0 g 1.68 7.51 body weighing method 0 12489 266
SS.LEW-(D1Rat35-D1Rat49)/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 304.0 g 2.97 13.28 body weighing method 0 12496 266
SS.LEW-(D1Rat196-D1Mgh7)/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 294.0 g 3.72 16.64 body weighing method 0 12501 266
SS.LEW-(D1Rat196-D1Mco36)/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 303.0 g 2.91 13.01 body weighing method 0 12502 266
SS.LEW-(D1Uia8-D1Rat124)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 298.0 g 2.53 11.31 body weighing method 0 12506 266
SS.LEW-(D1Mco36-D1Rat49)/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.74 g/kg 0.04 0.17 post excision weight measurement 0 12561 266
SS.LEW-(D1Uia2-D1Rat49)/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.94 g/kg 0.03 0.14 post excision weight measurement 0 12563 266
SS.LEW-(D18Rat61-D18Rat45)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 6 141.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry aorta 0 12599 269
SS/Jr mean arterial blood pressure controlled sodium content diet (8 %) (between 21 and 25 days) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. arterial blood pressure trait male 82 days-86 days 69 serial mean 187.0 mmHg vascular fluid filled catheter femoral artery 345600 0 connected to solid-state transducer (Argon Medical Technologies, Athens, TX) 5 hr recording session - 1 min. averages, averaged over 4 days 12613 272
SS.LEW-(D5Rat130-D5Rat72)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 21 and 25 days) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. arterial blood pressure trait male 82 days-86 days 32 serial mean 190.0 mmHg vascular fluid filled catheter femoral artery 345600 0 connected to solid-state transducer (Argon Medical Technologies, Athens, TX) 5 hr recording session - 1 min. averages, averaged over 4 days 12614 272
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 30 1.3 g 0.01 0.07 post excision weight measurement 0 0 12846 313
SS.LEW-(D1Mco36-D1Rat131)/2Mco heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 1.11 g 0.01 0.06 post excision weight measurement 0 0 12854 313
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. body mass male 64 days-66 days 20 314.0 g 2.23 9.97 body weighing method 0.0 0 12863 313
SS.LEW-(D1Mco36-D1Rat131)/1Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. body mass male 64 days-66 days 20 305.0 g 2.4 10.73 body weighing method 0 0 12873 313
SS.LEW-(D1Mco85-D1Rat49)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. body mass male 64 days-66 days 20 316.0 g 2.87 12.84 body weighing method 0 0 12878 313
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 3.89 g/kg 0.02 0.1 post excision weight measurement 0 0 12884 313
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 30 3.98 g/kg 0.03 0.16 post excision weight measurement 0 0 12886 313
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.25 g 0.02 0.07 post excision weight measurement 0 12517 266
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.29 g 0.02 0.08 post excision weight measurement 0 regression of heart weight on body weight 12522 266
SS.LEW-(D1Mco2-D1Rat49)/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.14 g 0.01 0.05 post excision weight measurement 0 12525 266
SS.LEW-(D1Uia8-D1Rat18)/Mco heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.19 g 0.01 0.06 post excision weight measurement 0 regression of heart weight on body weight 12535 266
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 10 175.0 mmHg 4.0 12.65 intra-aortic abdominal radiotelemetry aorta 0 12544 269
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 4.32 g/kg 0.06 0.25 post excision weight measurement 0 12545 266
SHRSP systolic blood pressure controlled sodium content diet (0.4 %) (for 63 days) Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. arterial blood pressure trait male 91 days 4 serial mean 219.5 mmHg 7.65 15.3 tail cuff photoplethysmography 0 0 UR1000; Ueda average of 3 consistent readings 12556 268
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.85 g/kg 0.06 0.26 post excision weight measurement 0 12555 266
SS.LEW-(D1Uia8-D1Rat18)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.89 g/kg 0.04 0.19 post excision weight measurement 0 12567 266
SS.LEW-(D1Uia8-D1Rat213)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.45 g/kg 0.06 0.26 post excision weight measurement 0 12570 266
WKY body weight controlled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days) Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. body mass female 360 days 4 200.8 g 3.45 6.9 body weighing method 0 0 12589 268
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.26 g 0.03 0.13 digital scale post excision weight measurement 0 0 12669 282
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.25 g 0.01 0.04 digital scale post excision weight measurement 0 0 12671 282
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 30 1.25 g 0.01 0.07 digital scale post excision weight measurement 0 0 12677 282
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 33 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 73 days-75 days 10 211.0 mmHg 2.05 6.48 radiotelemetry 345600 0 C-40 transmitter (Data Sciences International, St. Paul, MN) aveerage of 4-hour interval averages over 4 days 12915 313
SS/Jr pulse pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 33 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 73 days-75 days 10 58.0 mmHg 0.38 1.2 radiotelemetry 345600 0 C-40 transmitter (Data Sciences International, St. Paul, MN) aveerage of 4-hour interval averages over 4 days 12922 313
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 311.0 g 1.63 7.29 body weighing method 0 12944 305
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 339.0 g 3.0 13.42 body weighing method 0 12945 305
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 316.0 g 3.93 17.58 body weighing method 0 12942 305
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 318.0 g 2.09 9.35 body weighing method 0 12947 305
SS.SHR-(D9Mco74-D9Rat64)/Mco body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 321.0 g 6.99 31.26 body weighing method 0 12955 305
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 20 1.4 g 0.03 0.12 post excision weight measurement 0 12966 305
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 6 1.39 g 0.03 0.08 post excision weight measurement 0 12964 305
SS.SHR-(D9Wox16-D9Rat76)/Mco heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 20 1.5 g 0.02 0.09 post excision weight measurement 0 12969 305
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 3 4.32 g/kg 0.24 0.42 post excision weight measurement 0 12984 305
SS.SHR-(D9Mco74-D9Rat64)/Mco heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 5 3.47 g/kg 0.06 0.13 post excision weight measurement 0 12997 305
SS.MNS-(D2Chm25-D2Rat131)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 5 139.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry 0 12358 242
SS.MNS-(D2Rat183-D2Chm113)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 8 145.0 mmHg 4.0 11.31 intra-aortic abdominal radiotelemetry 0 12355 242
SHR/NHsd serum triglyceride level controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. blood triglyceride amount male 28 days-84 days 8 51.0 mg/dl 3.7 10.47 automated blood analysis 0 0 12402 246
SS.LEW-(D10Rat29-D10Got93)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 20 serial mean 184.0 mmHg 3.05 13.64 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13131 282
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96 days 21 continuous mean 96.0 mmHg 3.0 13.75 vascular indwelling catheter method femoral artery 10800.0 0 left femoral artery 13275 229
SS.LEW-(D10Chm10-D10Rat11)/Ayd plasma sodium level controlled sodium content diet (8 %) (between 8 and 10 days) Huang BS, et al., Hypertension. 2007 Apr 9;. blood sodium amount male 43 days-52 days 10 147.0 mmol/l 3.0 9.49 sodium ion-selective electrode method 0 sodium ion-selective electrode 13320 344
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 92 days 7 2.2 ng/ml/h 0.58 1.53 ex vivo blood analysis 0.0 0 enzyme assay 13307 151
SS.SHR-(D9Mco72-D9Rat89)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 183.0 mmHg 7.72 tail cuff plethysmography 0.0 0 67510 749
SS.SHR-(D9Mco72-D9Mco109)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 188.0 mmHg 3.21 tail cuff plethysmography 0.0 0 67514 749
SS.SHR-(D9Rat7-D9Mco91)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 208.0 mmHg 5.78 tail cuff plethysmography 0.0 0 67525 749
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. body mass not specified 0 days 0 353.0 g 6.24 body weighing method 0.0 0 67537 749
SS.SHR-(D9Mco72-D9Rat55)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 3.99 g/kg 0.04 post excision weight measurement 0.0 0 67563 749
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 102.0 mg/d 6.81 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67580 749
SS.SHR-(D9Rat7-D9Rat52)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.12 g/kg 0.07 post excision weight measurement 0.0 0 67577 749
SS.SHR-(D9Mco72-D9Rat89)/Mco urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 72.0 mg/d 5.44 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67579 749
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.36 g/kg 0.07 post excision weight measurement 0.0 0 67572 749
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 94.0 mg/d 7.54 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67584 749
SS.LEW-(D5Mit9-D5Mco10)/Jr heart wet weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 40 1.07 g 0.01 0.06 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64761 222
SS-Chr 16BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 167.62 % 15.92 42.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17915 381
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 113.63 % 4.18 12.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17920 381
SS/Jr heart wet weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 19 1.21 g 0.02 0.07 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64764 222
SS.LEW-(D10Mit10-D10Mgh1)/Jr heart wet weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 20 1.1 g 0.01 0.05 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64763 222
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 136.37 % 4.67 14.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17923 381
SS.LEW-(D17Mco3-D17Mco10)/Jr heart wet weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 20 1.19 g 0.02 0.07 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64765 222
SS.LEW-(D18Rat30-D18Chm29)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 8 3.5 g/kg 0.1 0.28 post excision weight measurement 0 0 64802 226
SS.SHR-(D9Mco72-D9Mco93)/Mco heart rate controlled sodium content diet (2 %) (for 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart pumping trait male 75 days-79 days 5 389.0 beats/min 9.6 21.47 intra-aortic abdominal radiotelemetry 172800 0 64989 305
LEW mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 23 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. arterial blood pressure trait male 56 days-60 days 6 95.0 mmHg 1.22 3.0 radiotelemetry 86400 0 two 24 hours widely separated periods, data represent averages of all readings over the 24-h measurements 64994 542
SS.LEW-(D18Chm41-D18Rat92)/Ayd body weight controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. body mass male 77 days 8 326.1 g 3.22 9.1 body weighing method 0 0 65007 542
SS.LEW-(D18Rat29-D18Rat55)/Ayd heart left ventricle wet weight controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle mass male 77 days 11 0.89 g 0.03 0.11 post excision weight measurement 0 0 65029 542
GH/OmrMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during7-9 min hypoxia/control during standard conditions 142.36 % 11.33 32.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18371 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during7-9 min hypoxia/control during standard conditions 133.83 % 7.44 16.65 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18372 381
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 127.69 % 6.86 26.56 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18368 381
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 5 157.0 g 3.3 7.38 whole body digital scale 0 63649 529
FHH-Egln3m1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 14 189.86 g 2.91 10.9 whole body digital scale 0 63647 529
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 29 153.38 g 1.84 9.91 whole body digital scale 0 63651 529
FHH-Agtr1bm1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 12 40.63 cm 0.89 3.08 in vivo ruler method 0 63662 529
FHH-Lcatm1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 15 38.3 cm 0.31 1.21 in vivo ruler method 0 63666 529
FHH-F10m1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 10 38.45 cm 0.22 0.69 in vivo ruler method 0 63676 529
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 3 35.83 cm 0.33 0.58 in vivo ruler method 0 63677 529
FHH-Nr4a1m1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 14 41.0 cm 0.54 2.04 in vivo ruler method 0 63684 529
FHH/EurMcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 28 38.84 cm 0.42 2.22 in vivo ruler method 0 63698 529
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 3 35.0 cm 0.58 1.0 in vivo ruler method 0 63701 529
FHH-Ghsrm1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 15 42.73 cm 0.2 0.78 in vivo ruler method 0 63704 529
F344-AbatTn(sb-T2/Bart3)2.163Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 5 35.0 cm 0.45 1.0 in vivo ruler method 0 63711 529
FHH-Tlr4m1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 11 37.91 cm 0.32 1.07 in vivo ruler method 0 63717 529
FHH-Slc8a2m1Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 13 0.51 g 0.01 0.05 digital scale post excision weight measurement 0 63739 529
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 3 0.36 g 0.01 0.02 digital scale post excision weight measurement 0 63740 529
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 5 0.4 g 0.01 0.03 digital scale post excision weight measurement 0 63745 529
FHH-F10m2Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 10 0.52 g 0.01 0.04 digital scale post excision weight measurement 0 63762 529
FHH-F10m1Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass male 70 days-84 days 10 0.65 g 0.01 0.05 digital scale post excision weight measurement 0 63763 529
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass male 70 days-84 days 1 0.49 g digital scale post excision weight measurement 0 63772 529
F344-DccTn(sb-T2/Bart3)2.205Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass male 70 days-84 days 7 0.53 g 0.04 0.09 digital scale post excision weight measurement 0 63778 529
FHH-Adipoqm3Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 7 0.55 g 0.01 0.03 digital scale post excision weight measurement 0 63779 529
FHH-Adra1am1Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 9 0.55 g 0.01 0.02 digital scale post excision weight measurement 0 63784 529
FHH-Adra1am1Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass male 70 days-84 days 9 0.7 g 0.01 0.03 digital scale post excision weight measurement 0 63782 529
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 2 0.37 g 0.01 0.02 digital scale post excision weight measurement 0 63787 529
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during 2-3 min hypoxia/control during standard conditions 187.88 % 14.16 31.67 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19300 381
LEW/Crl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 %change=VE during 2-3 min hypoxia/control during standard conditions 138.23 % 5.11 22.86 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19306 381
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 151.33 % 5.57 20.09 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19309 381
SHR/NHsd serum total cholesterol level controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. blood cholesterol amount male 84 days 8 54.0 mg/dl 2.4 6.79 automated blood analysis 0 0 64811 246
SS/Jr serum albumin level controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. blood albumin amount male 84 days 8 2.9 g/dl 0.06 0.17 automated blood analysis 0 0 64820 246
SS.BN-(D13Rat20-D13Rat127)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait female 86 days-89 days 12 153.0 mmHg 4.7 16.28 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 65168 15
SS.BN-(D13Rat127-D13Rat77)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 175.0 mmHg 4.4 15.24 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 65182 15
SS.BN-(D13Rat101-D13Rat46)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait female 86 days-89 days 12 149.0 mmHg 3.7 12.82 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 65187 15
SS.BN-(D13Rat61-D13GRat197)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 183.0 mmHg 2.9 10.05 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 65190 15
SS.BN-(D13Rat151-D13Rat197)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 172.0 mmHg 3.6 12.47 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 65198 15
SHR.BN-(D2Rat226-D2Rat294)/Jk heart rate controlled sodium content diet (1 %) (for 14 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. heart pumping trait male 87 days 22 continuous mean 350.0 beats/min 4.0 18.76 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65421 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk heart rate controlled sodium content diet (1 %) (for 14 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. heart pumping trait male 87 days 23 continuous mean 354.0 beats/min 8.0 38.37 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65425 306
SHR.BN-(D2Rat114-D2Rat123)/Jk body weight controlled sodium content diet (1 %) (for 14 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. body mass male 87 days 23 273.0 g 7.0 33.57 body weighing method 0 0 65431 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk body weight controlled sodium content diet (1 %) (for 14 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. body mass male 87 days 23 271.0 g 5.0 23.98 body weighing method 0 0 65437 306
SS-Klf4m3Mcwi heart wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart mass male 70 days-84 days 9 1.08 g 0.02 0.05 digital scale post excision weight measurement 0 63229 529
SS-Ghsrm3Mcwi heart wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 2 0.8 g 0.02 0.03 digital scale post excision weight measurement 0 63231 529
SS-Klf4m3Mcwi body weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data body mass male 70 days-84 days 9 301.11 g 5.71 17.14 whole body digital scale 0 63239 529
SS-Klf4m3Mcwi heart right ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 9 0.16 g 0.0 0.01 digital scale post excision weight measurement 0 63248 529
SS/JrHsdMcwi heart right ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 17 0.13 g 0.0 0.02 digital scale post excision weight measurement 0 63252 529
FHH-Nr0b2m1Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 8 0.13 g 0.01 0.02 digital scale post excision weight measurement 0 63264 529
FHH-Agtr1bm1Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70 days-84 days 15 0.19 g 0.01 0.02 digital scale post excision weight measurement 0 63272 529
FHH-Tgfbr2m2Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 14 0.13 g 0.0 0.01 digital scale post excision weight measurement 0 63273 529
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 3 0.1 g 0.0 0.01 digital scale post excision weight measurement 0 63278 529
FHH-Agtr1bm1Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 14 0.16 g 0.01 0.02 digital scale post excision weight measurement 0 63279 529
FHH-F10m1Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 10 0.14 g 0.0 0.01 digital scale post excision weight measurement 0 63286 529
FHH-Ccr2m1Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 7 0.14 g 0.01 0.01 digital scale post excision weight measurement 0 63285 529
F344/NHsd heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70 days-84 days 10 0.11 g 0.0 0.01 digital scale post excision weight measurement 0 63290 529
FHH-Nr4a1m1Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70 days-84 days 14 0.18 g 0.01 0.03 digital scale post excision weight measurement 0 63294 529
FHH-F10m2Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 10 0.17 g 0.01 0.02 digital scale post excision weight measurement 0 63300 529
FHH-Nr4a1m1Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 13 0.15 g 0.0 0.01 digital scale post excision weight measurement 0 63302 529
FHH-Ghsrm1Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 10 0.16 g 0.0 0.02 digital scale post excision weight measurement 0 63306 529
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70 days-84 days 1 0.12 g digital scale post excision weight measurement 0 63304 529
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 4 0.1 g 0.0 0.01 digital scale post excision weight measurement 0 63313 529
F344-DccTn(sb-T2/Bart3)2.205Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70 days-84 days 7 0.22 g 0.05 0.12 digital scale post excision weight measurement 0 63316 529
FHH-Adipoqm3Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 7 0.18 g 0.01 0.02 digital scale post excision weight measurement 0 63317 529
BN/NHsdMcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 29 0.11 g 0.0 0.01 digital scale post excision weight measurement 0 63333 529
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 8 1.01 g 0.02 0.05 digital scale post excision weight measurement 0 63346 529
FHH-Agtr1bm1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 14 0.89 g 0.02 0.08 digital scale post excision weight measurement 0 63351 529
FHH-Slc8a2m1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 13 0.83 g 0.02 0.08 digital scale post excision weight measurement 0 63349 529
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 5 0.62 g 0.01 0.03 digital scale post excision weight measurement 0 63355 529
FHH-Ccr2m1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 7 0.88 g 0.02 0.05 digital scale post excision weight measurement 0 63357 529
FHH-Nr4a1m1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 14 1.18 g 0.02 0.09 digital scale post excision weight measurement 0 63366 529
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 1 0.85 g digital scale post excision weight measurement 0 63376 529
FHH-Nr4a1m1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 13 0.94 g 0.03 0.09 digital scale post excision weight measurement 0 63374 529
BN-Lcatm3Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 1 0.88 g digital scale post excision weight measurement 0 63384 529
FHH-Slc8a2m1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 15 1.16 g 0.02 0.08 digital scale post excision weight measurement 0 63398 529
FHH-Egln3m1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 14 0.95 g 0.03 0.11 digital scale post excision weight measurement 0 63401 529
FHH-Adipoqm1Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 10 0.75 g 0.02 0.06 digital scale post excision weight measurement 0 63409 529
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass male 70 days-84 days 2 0.83 g 0.03 0.05 digital scale post excision weight measurement 0 63412 529
FHH-Agtr1bm1Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 14 0.79 g 0.02 0.06 digital scale post excision weight measurement 0 63423 529
FHH-Nr0b2m1Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass male 70 days-84 days 10 1.0 g 0.01 0.04 digital scale post excision weight measurement 0 63424 529
FHH-Nr4a1m1Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass male 70 days-84 days 14 1.03 g 0.03 0.11 digital scale post excision weight measurement 0 63438 529
FHH-F10m1Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass male 70 days-84 days 10 0.96 g 0.03 0.08 digital scale post excision weight measurement 0 63445 529
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass male 70 days-84 days 1 0.87 g digital scale post excision weight measurement 0 63448 529
FHH/EurMcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 28 0.79 g 0.02 0.1 digital scale post excision weight measurement 0 63452 529
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 4 0.59 g 0.02 0.03 digital scale post excision weight measurement 0 63457 529
F344-AbatTn(sb-T2/Bart3)2.163Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 5 0.58 g 0.02 0.04 digital scale post excision weight measurement 0 63465 529
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 2 0.54 g 0.01 0.02 digital scale post excision weight measurement 0 63469 529
FHH-Adra1am1Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 9 0.79 g 0.01 0.03 digital scale post excision weight measurement 0 63466 529
F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass male 70 days-84 days 8 0.84 g 0.03 0.08 digital scale post excision weight measurement 0 63474 529
SS-Klf4m3Mcwi heart left ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 9 0.55 g 0.01 0.02 digital scale post excision weight measurement 0 63484 529
SS/JrHsdMcwi heart left ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart left ventricle mass male 70 days-84 days 47 0.8 g 0.02 0.13 digital scale post excision weight measurement 0 63482 529
SS-Sod3m1Mcwi heart left ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 13 0.63 g 0.02 0.06 digital scale post excision weight measurement 0 63489 529
SS-Klf4m3Mcwi body length, nose to rump controlled sodium content diet (1 %) (for 14 days) PhysGen General data body length female 70 days-84 days 9 20.94 cm 0.19 0.58 in vivo ruler method 0 63494 529
SS-Ghsrm3Mcwi body length, nose to rump controlled sodium content diet (1 %) (for 14 days) PhysGen General data body length female 70 days-84 days 2 20.0 cm 1.0 1.41 in vivo ruler method 0 63497 529
FHH-Tgfbr2m2Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 14 24.29 cm 0.19 0.7 in vivo ruler method 0 63503 529
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 2 23.5 cm 0.5 0.71 in vivo ruler method 0 63504 529
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 2 20.0 cm 0.0 0.0 in vivo ruler method 0 63511 529
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 3 19.67 cm 0.33 0.58 in vivo ruler method 0 63514 529
FHH-Nr0b2m1Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 10 23.95 cm 0.29 0.93 in vivo ruler method 0 63516 529
BN-Tgfbr2m1Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 7 23.21 cm 0.15 0.39 in vivo ruler method 0 63517 529
FHH-Htr1am1Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 12 21.63 cm 0.25 0.88 in vivo ruler method 0 63525 529
FHH-F10m1Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 10 22.05 cm 0.09 0.28 in vivo ruler method 0 63522 529
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 1 20.0 cm in vivo ruler method 0 63528 529
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 4 22.5 cm 1.54 3.08 in vivo ruler method 0 63534 529
FHH-Nr4a1m1Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 13 21.65 cm 0.2 0.72 in vivo ruler method 0 63538 529
F344-DccTn(sb-T2/Bart3)2.205Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 6 20.42 cm 0.2 0.49 in vivo ruler method 0 63539 529
FHH/EurMcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 28 21.7 cm 0.17 0.91 in vivo ruler method 0 63544 529
SS-Klf4m3Mcwi left kidney wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 9 1.33 g 0.03 0.1 digital scale post excision weight measurement 0 63577 529
SS/JrHsdMcwi left kidney wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 47 1.43 g 0.03 0.21 digital scale post excision weight measurement 0 63574 529
FHH-Lcatm1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass male 70 days-84 days 13 254.77 g 7.26 26.17 whole body digital scale 0 63587 529
FHH-Agtr1bm1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass male 70 days-84 days 15 257.0 g 5.04 19.51 whole body digital scale 0 63590 529
BN-Tgfbr2m1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 3 148.33 g 2.33 4.04 whole body digital scale 0 63588 529
BN-Tgfbr2m1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass male 70 days-84 days 7 239.0 g 5.67 14.99 whole body digital scale 0 63599 529
FHH-Htr1am1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 13 180.77 g 3.57 12.87 whole body digital scale 0 63607 529
FHH-Ccr2m1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass male 70 days-84 days 10 260.1 g 3.51 11.1 whole body digital scale 0 63611 529
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 8 172.88 g 4.25 12.02 whole body digital scale 0 63614 529
F344/NHsd body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 10 128.5 g 2.13 6.72 whole body digital scale 0 63617 529
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 4 139.75 g 4.42 8.85 whole body digital scale 0 63623 529
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass male 70 days-84 days 7 274.57 g 3.98 10.52 whole body digital scale 0 63625 529
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 3 165.33 g 6.69 11.59 whole body digital scale 0 63629 529
FHH-Lcatm1Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -8.22 null 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63066 528
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 3 -8.07 null 0.04 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63068 528
FHH-Htr1am1Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 -8.03 null 0.07 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63079 528
FHH-Nr0b2m1Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 4 -8.24 null 0.29 0.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63070 528
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 1 -8.24 null wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63082 528
FHH-Ccr2m1Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 -8.02 null 0.11 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63083 528
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 4 -8.21 null 0.15 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63088 528
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 1 -8.05 null wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63094 528
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 2 0.85 g/mg 0.07 0.1 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63135 528
FHH-F10m1Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 7 1.41 g/mg 0.09 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63146 528
F344-DccTn(sb-T2/Bart3)2.205Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 3 1.27 g/mg 0.32 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63162 528
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 1 1.22 g/mg wire myography using a Digi-Med tissue force analysis system with force transducer 0 63168 528
FHH-Egln3m1Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 6 1.39 g/mg 0.09 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63174 528
FHH-Tlr4m1Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 12 1.56 g/mg 0.15 0.53 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63181 528
SS-Cpt2m1Mcwi body weight controlled sodium content diet (1 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 5 309.6 g 2.01 4.51 whole body digital scale 0 63195 528
SS/Jr heart wet weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 40 1.24 g 0.01 0.05 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64747 222
SS.SR-(D13N1-D13Mit1)/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 24 days) then controlled sodium content diet (4 %) (for 24 days) Zhang QY, et al., Mamm Genome 1997 Sep;8(9):636-41 arterial blood pressure trait not specified 65 days-68 days 26 data obtained at three consistent sessions per day serial mean 217.0 mmHg tail cuff plethysmography 345600 0 66029 650
SS-Chr 19SHR/Rkb body weight controlled sodium content diet (0.2 %) (for 56 days) Wendt N, et al., J Hypertens. 2007 Jan;25(1):95-102. body mass male 98 days 20 355.0 g 8.0 35.78 body weighing method 0 0 66084 669
SS-Chr 19SHR/Rkb body weight controlled sodium content diet (4 %) (for 56 days) Wendt N, et al., J Hypertens. 2007 Jan;25(1):95-102. body mass male 98 days 20 355.0 g 9.0 40.25 body weighing method 0 0 66085 669
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.17 g 0.06 0.12 post excision weight measurement 0 - 66203 717
SS-Gpr183em1Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 6 1.57 g 0.07 0.18 post excision weight measurement 0 - 66207 717
SS-Mthfrem1Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 1 1.61 g post excision weight measurement 0 - 66211 717
SS-Gpr183em2Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 9 1.58 g 0.05 0.15 post excision weight measurement 0 - 66216 717
SS-Ncf2em1Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.45 g 0.04 0.08 post excision weight measurement 0 - 66221 717
SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 2 1.46 g 0.06 0.08 post excision weight measurement 0 - 66223 717
SS-Nckap5em1Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.77 g 0.11 0.24 post excision weight measurement 0 - 66232 717
SS-Apoeem7Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.42 g 0.04 0.09 post excision weight measurement 0 - 66231 717
SS-Itga9em1Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 4 1.49 g 0.05 0.11 post excision weight measurement 0 - 66253 717
SS-Acad10em2Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 13 322.6 g 4.1 14.6 whole body digital scale 0 - 66272 717
SS-Gpr183em1Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 6 296.2 g 4.9 12.1 whole body digital scale 0 - 66269 717
SS-Tfdp2em2Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 3 328.3 g 6.4 11.2 whole body digital scale 0 - 66277 717
SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 2 319.5 g 2.5 3.5 whole body digital scale 0 - 66285 717
SS-Rag1em2Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 8 302.0 g 8.6 24.4 whole body digital scale 0 - 66298 717
SS-Apoeem8Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 2 332.5 g 13.5 19.1 whole body digital scale 0 - 66301 717
SS-Ets1em1Mcwi-/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 10 311.7 g 11.4 36.0 whole body digital scale 0 - 66309 717
SS-Rag1em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 331.75 beats/min 29.0 58.01 radiotelemetry carotid artery 0 - 66330 717
SS-Mmp2em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 5 362.0 beats/min 6.58 14.71 radiotelemetry carotid artery 0 - 66328 717
SS-Mmp2em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 359.0 beats/min radiotelemetry carotid artery 0 - 66352 717
SS-Ets1em1Mcwi-/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 7 339.14 beats/min 7.28 19.26 radiotelemetry carotid artery 0 - 66369 717
SS-Acad10em2Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 5 350.8 beats/min 4.97 11.12 radiotelemetry carotid artery 0 - 66383 717
SS-Gpr183em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 154.5 mmHg 10.53 25.8 radiotelemetry carotid artery 0 - 66391 717
SS-Acad10em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 12 1/3 systolic pressure + 2/3 diastolic pressure 133.5 mmHg 8.13 28.15 radiotelemetry carotid artery 0 - 66394 717
SS-Mthfrem1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 128.0 mmHg radiotelemetry carotid artery 0 - 66395 717
SS-Apoeem8Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 136.4 mmHg 6.02 13.46 radiotelemetry carotid artery 0 - 66402 717
SS-Gpr183em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 137.0 mmHg 13.0 18.38 radiotelemetry carotid artery 0 - 66404 717
FHH-Chr 1BN-Sorcs1em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 103.33 mmHg 8.71 21.32 radiotelemetry carotid artery 0 - 66406 717
SS-Rag1em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 126.33 mmHg 2.22 5.43 radiotelemetry carotid artery 0 - 66418 717
SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 130.33 mmHg 5.21 9.02 radiotelemetry carotid artery 0 - 66427 717
SS-Tfdp2em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 135.33 mmHg 12.39 21.46 radiotelemetry carotid artery 0 - 66432 717
SS-Nckap5em3Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 138.0 mmHg 8.08 14.0 radiotelemetry carotid artery 0 - 66437 717
SS-Nckap5em3Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 127.5 mmHg 2.5 3.54 radiotelemetry carotid artery 0 - 66440 717
SS-Mas1em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 121.0 mmHg radiotelemetry carotid artery 0 - 66442 717
SS-Bcas3em4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 /3 systolic pressure + 2/3 diastolic pressure 145.33 mmHg 15.1 26.16 radiotelemetry carotid artery 0 - 66461 717
FHH-Chr 1BN-Sorcs1em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 /3 systolic pressure + 2/3 diastolic pressure 111.5 mmHg 5.37 13.14 radiotelemetry carotid artery 0 - 66466 717
SS-Apoeem7Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 /3 systolic pressure + 2/3 diastolic pressure 114.67 mmHg 2.96 5.13 radiotelemetry carotid artery 0 - 66469 717
SS-Chr 5BN-Cyp4a2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 /3 systolic pressure + 2/3 diastolic pressure 131.33 mmHg 14.89 25.79 radiotelemetry carotid artery 0 - 66468 717
SS-Mmp2em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 /3 systolic pressure + 2/3 diastolic pressure 161.0 mmHg radiotelemetry carotid artery 0 - 66477 717
SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 /3 systolic pressure + 2/3 diastolic pressure 136.0 mmHg 6.51 11.27 radiotelemetry carotid artery 0 - 66487 717
SS-Mthfrem1Mcwi-/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 8 /3 systolic pressure + 2/3 diastolic pressure 129.62 mmHg 4.21 11.92 radiotelemetry carotid artery 0 - 66501 717
SS-Acad10em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 /3 systolic pressure + 2/3 diastolic pressure 136.6 mmHg 3.54 7.92 radiotelemetry carotid artery 0 - 66503 717
SS-Ncf2em1Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 6 90.75 mg/d 13.96 34.19 automated urine analysis 0 - 66506 717
SS-Tgfb1em3Mcwi+/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 3 90.77 mg/d 21.1 36.55 automated urine analysis 0 - 66517 717
SS-Gpr183em2Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 2 105.13 mg/d 2.81 3.97 automated urine analysis 0 - 66524 717
SS-Nckap5em1Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 5 210.12 mg/d 50.65 113.25 automated urine analysis 0 - 66536 717
SS-Rag1em2Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 8 56.65 mg/d 5.76 16.3 automated urine analysis 0 - 66539 717
SS-Apoeem8Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 2 79.35 mg/d 6.61 9.35 automated urine analysis 0 - 66542 717
SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 4 85.9 mg/d 4.77 9.54 automated urine analysis 0 - 66548 717
SS-Alms1em1Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 1 388.77 mg/d automated urine analysis 0 - 66545 717
SS-Rag1em2Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 1 95.7 mg/d automated urine analysis 0 - 66552 717
SS-Tfdp2em2Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 3 119.9 mg/d 40.27 69.76 automated urine analysis 0 - 66553 717
SS-Nckap5em3Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 2 87.01 mg/d 23.91 33.82 automated urine analysis 0 - 66561 717
SS-Ncf2em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 349.17 beats/min 7.7 18.85 radiotelemetry carotid artery 0 - 66567 717
SS-Rag1em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 317.67 beats/min 12.35 21.39 radiotelemetry carotid artery 0 - 66571 717
SS-Acad10em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 13 339.62 beats/min 10.51 37.88 radiotelemetry carotid artery 0 - 66575 717
SS-Ets1em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 360.67 beats/min 8.21 14.22 radiotelemetry carotid artery 0 - 66594 717
SS-Nckap5em3Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 353.0 beats/min 14.5 25.12 radiotelemetry carotid artery 0 - 66618 717
SS-Ube2q2em3Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 320.5 beats/min 28.5 40.31 radiotelemetry carotid artery 0 - 66626 717
SS-Mmp2em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 148.6 mmHg 10.55 23.59 radiotelemetry carotid artery 0 - 66629 717
SS-Ncf2em1Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 5 1.16 g 0.06 0.13 post excision weight measurement 0 - 67013 717
SR/Hsd mean arterial blood pressure controlled sodium content diet (4 %) Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1. arterial blood pressure trait male 35 days-56 days 0 110.0 mmHg 4.0 tail cuff plethysmography 0.0 0 DR strain is from Charles River Laboratory, Wilmington, MA 67234 731
SS-Adra2aem1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 8 358.13 beats/min 7.03 19.89 radiotelemetry carotid artery 0 - 43443 421
SS-Wdr72em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 7 367.43 beats/min 4.67 12.37 radiotelemetry carotid artery 0 - 43442 421
SS-Rasgrp3em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 364.25 beats/min 5.76 11.53 radiotelemetry carotid artery 0 - 43444 421
SS-Hexim2em4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 10 376.9 beats/min 7.43 23.5 radiotelemetry carotid artery 0 - 43455 421
SS-Rasgrp3em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 10 1/3 systolic pressure + 2/3 diastolic pressure 167.4 mmHg 13.72 43.39 radiotelemetry carotid artery 0 - 43460 421
SS-Hexim2em4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 139.5 mmHg 0.5 0.71 radiotelemetry carotid artery 0 - 43465 421
SS-Ulk3em4Mcwi-/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 134.0 mmHg 4.16 7.21 radiotelemetry carotid artery 0 - 43467 421
SS-Agtrapem4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 152.0 mmHg 8.74 15.13 radiotelemetry carotid artery 0 - 43468 421
SS-Rasgrp3em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 126.75 mmHg 4.94 9.88 radiotelemetry carotid artery 0 - 43475 421
SS-Adra2aem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 8 1/3 systolic pressure + 2/3 diastolic pressure 126.88 mmHg 3.12 8.82 radiotelemetry carotid artery 0 - 43474 421
SS-Wdr72em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 7 1/3 systolic pressure + 2/3 diastolic pressure 123.71 mmHg 3.66 9.69 radiotelemetry carotid artery 0 - 43473 421
SS-Ulk3em4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 14 1/3 systolic pressure + 2/3 diastolic pressure 130.43 mmHg 5.11 19.14 radiotelemetry carotid artery 0 - 43481 421
SS-Sh2b3em1Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 18 315.9 g 5.3 22.7 whole body digital scale 0 - 43487 421
SS-Sh2b3em1Mcwi-/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 3 300.7 g 1.8 3.1 whole body digital scale 0 - 43494 421
SS-Agtrapem4Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 7 326.6 g 8.7 23.0 whole body digital scale 0 - 43500 421
SS-Rasgrp3em1Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 6 83.33 mg/d 11.28 27.64 automated urine analysis 0 - 43506 421
SS-Sh2b3em1Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 1 86.52 mg/d automated urine analysis 0 - 43508 421
SS-Sh2b3em1Mcwi-/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 3 56.13 mg/d 4.75 8.22 automated urine analysis 0 - 43510 421
SS-Sh2b3em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 13 349.62 beats/min 7.36 26.54 radiotelemetry carotid artery 0 - 43519 421
SS-Hexim2em4Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 10 101.7 mg/d 15.79 49.93 automated urine analysis 0 - 43518 421
SS-Ulk3em4Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 357.5 beats/min 10.5 14.85 radiotelemetry carotid artery 0 - 43527 421
SS-Ulk3em4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 14 351.21 beats/min 6.25 23.4 radiotelemetry carotid artery 0 - 43529 421
SS-Rasgrp3em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 130.33 mmHg 3.96 9.71 radiotelemetry carotid artery 0 - 43538 421
SS-Ulk3em4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 15 1/3 systolic pressure + 2/3 diastolic pressure 126.53 mmHg 2.65 10.27 radiotelemetry carotid artery 0 - 43545 421
SS-Ulk3em4Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 2 10.65 mg/d 0.35 0.49 automated urine analysis 0 - 43559 421
SS-Ulk3em4Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 19 10.36 mg/d 0.29 1.25 automated urine analysis 0 - 43561 421
SS-Rasgrp3em1Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 6 10.59 mEq/d 1.06 2.59 automated urine analysis 0 - 43570 421
SS-Sh2b3em1Mcwi-/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 3 16.02 mg/d 3.39 5.88 automated urine analysis 0 - 43590 421
SS-Ulk3em4Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 18 33.71 mg/d 4.51 19.14 automated urine analysis 0 - 43593 421
SS-Sh2b3em1Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 13 1.35 g 0.03 0.12 post excision weight measurement 0 - 43599 421
SS-Ulk3em4Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 18 1.41 g 0.04 0.15 post excision weight measurement 0 - 43607 421
SS-Wdr72em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 124.83 mmHg 5.18 12.69 radiotelemetry carotid artery 0 - 43614 421
SS-Agtrapem4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 7 1/3 systolic pressure + 2/3 diastolic pressure 133.06 mmHg 6.76 17.89 radiotelemetry carotid artery 0 - 43626 421
SS-Adra2aem1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 105.0 mmHg 9.26 18.51 radiotelemetry carotid artery 0 - 43627 421
SS-Ulk3em4Mcwi-/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 4 1.35 g 0.1 0.21 post excision weight measurement 0 - 43638 421
SS-Hexim2em4Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 10 1.36 g 0.03 0.11 post excision weight measurement 0 - 43642 421
SS-Rasgrp3em1Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 10 1.18 g 0.03 0.08 post excision weight measurement 0 - 43647 421
SS-Rasgrp3em1Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 6 1.13 g 0.02 0.05 post excision weight measurement 0 - 43646 421
SS-Ulk3em4Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 2 1.16 g 0.07 0.1 post excision weight measurement 0 - 43649 421
SS-Agtrapem4Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 3 1.15 g 0.06 0.1 post excision weight measurement 0 - 43653 421
SS-Hexim2em4Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 10 1.13 g 0.02 0.07 post excision weight measurement 0 - 43656 421
SS-Wdr72em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 379.17 beats/min 7.66 18.76 radiotelemetry carotid artery 0 - 43658 421
SS-Rasgrp3em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 370.5 beats/min 8.41 20.61 radiotelemetry carotid artery 0 - 43676 421
SS-Ulk3em4Mcwi-/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 376.0 beats/min 20.0 28.28 radiotelemetry carotid artery 0 - 43684 421
SS-Agtrapem4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 354.24 beats/min 6.81 16.69 radiotelemetry carotid artery 0 - 43686 421
LEW heart left ventricle wet weight controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle mass male 77 days 14 0.72 g 0.03 0.13 post excision weight measurement 0 0 65027 542
SS/Jr heart left ventricle posterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle posterior wall thickness male 77 days 40 0.19 mm 0.0 0.02 transthoracic echocardiography 0 0 65115 542
SS.LEW-(D18Rat29-D18Rat55)/Ayd heart left ventricle posterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle posterior wall thickness male 77 days 11 0.18 mm 0.01 0.02 transthoracic echocardiography 0 0 65116 542
SS.LEW-(D3Rat52-D3Chm57)/Ayd heart left ventricle posterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle posterior wall thickness male 77 days 8 0.17 mm 0.0 0.01 transthoracic echocardiography 0 0 65121 542
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 0 and 672 hours) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart mass male 114 days-118 days 4 1.67 g 0.07 0.14 post excision weight measurement 0 0 65129 283
WKY/Bbb diastolic blood pressure controlled sodium content diet Kreutz R, et al., Proc Natl Acad Sci U S A 1995 Sep 12;92(19):8778-82 arterial blood pressure trait not specified 0 days 8 83.5 mmHg 0.92 2.6 radiotelemetry 0.0 0 67198 116
F344/NHsd serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 7 214.43 mg/dl 16.34 43.24 standard blood chemistry panel 0 62473 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 1 129.0 mg/dl standard blood chemistry panel 0 62475 527
FHH-Htr1am1Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 21 135.19 mg/dl 9.0 41.25 standard blood chemistry panel 0 62480 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 2 154.5 mg/dl 2.5 3.54 standard blood chemistry panel 0 62494 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 4 159.75 mg/dl 15.93 31.86 standard blood chemistry panel 0 62488 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 1 156.0 mg/dl standard blood chemistry panel 0 62493 527
F344-AbatTn(sb-T2/Bart3)2.163Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 3 164.33 mg/dl 54.11 93.72 standard blood chemistry panel 0 62507 527
F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 7 239.71 mg/dl 47.38 125.36 standard blood chemistry panel 0 62513 527
FHH-Egln3m1Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 14 166.14 mg/dl 10.3 38.55 standard blood chemistry panel 0 62512 527
BN/NHsdMcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 26 145.0 mg/dl 3.68 18.76 standard blood chemistry panel 0 62516 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 4 170.25 mg/dl 8.14 16.28 standard blood chemistry panel 0 62518 527
FHH-Tgfbr2m2Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 75.7 % 5.4 17.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62591 528
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 60.67 % 4.18 10.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62597 528
FHH-Ccr2m1Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 70.0 % 7.73 18.94 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62608 528
FHH-Adipoqm1Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 78.0 % 4.92 13.93 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62605 528
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 1 78.0 % wire myography using a Digi-Med tissue force analysis system with force transducer 0 62614 528
F344/NHsd acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 54.13 % 6.82 19.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62621 528
FHH-Adipoqm3Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 58.33 % 7.06 17.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62636 528
FHH-Adra1am1Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 73.75 % 5.49 15.53 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62641 528
FHH-Tlr4m1Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 65.18 % 4.49 14.88 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62646 528
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 66.75 % 4.42 12.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62651 528
FHH-Tgfbr2m2Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62735 528
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62741 528
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 4 0.01 umol/l 0.01 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62750 528
FHH-Procm1Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 0.06 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62755 528
F344/NHsd concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62757 528
FHH-Nr4a1m1Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 6 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62761 528
FHH-Ccr2m1Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62760 528
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 1 0.01 umol/l wire myography using a Digi-Med tissue force analysis system with force transducer 0 62771 528
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 3 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62772 528
FHH-Adipoqm3Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 7 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62783 528
F344-AbatTn(sb-T2/Bart3)2.163Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 1 0.0 umol/l wire myography using a Digi-Med tissue force analysis system with force transducer 0 62787 528
FHH-Slc8a2m1Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 15 0.02 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62792 528
F344-Erbb4Tn(sb-T2/Bart3)2.208Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 1 0.01 umol/l wire myography using a Digi-Med tissue force analysis system with force transducer 0 62794 528
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62798 528
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 5 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62800 528
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 5 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62799 528
SS-Sod3m1Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (1 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 1.17 g/mg 0.07 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62805 528
SS-Klf4m3Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (1 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 1.32 g/mg 0.07 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62807 528
FHH-Nr0b2m1Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 -7.0 null 0.19 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62811 528
FHH-Lcatm1Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.75 null 0.14 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62816 528
BN-Tgfbr2m1Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 2 -7.13 null 0.08 0.11 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62827 528
F344/NHsd logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 -6.61 null 0.18 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62835 528
FHH-Ccr2m1Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -7.03 null 0.18 0.53 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62838 528
FHH-Procm1Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 -7.11 null 0.13 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62840 528
FHH-Htr1am1Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -6.72 null 0.07 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62842 528
F344/NHsd logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -6.84 null 0.12 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62844 528
F344-DccTn(sb-T2/Bart3)2.205Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 -6.54 null 0.08 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62848 528
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 2 -7.13 null 0.12 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62851 528
F344-DccTn(sb-T2/Bart3)2.205Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 -6.88 null 0.06 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62857 528
FHH-Adipoqm3Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 -6.53 null 0.15 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62860 528
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 -7.7 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 62890 528
FHH-Nr0b2m1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70 days-84 days 3 167.33 g 3.53 6.11 whole body digital scale 0 62898 528
FHH-Tgfbr2m2Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 10 274.4 g 6.51 20.58 whole body digital scale 0 62901 528
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 7 280.43 g 7.61 20.14 whole body digital scale 0 62904 528
FHH-Tgfbr2m2Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70 days-84 days 9 177.78 g 3.04 9.13 whole body digital scale 0 62906 528
FHH-Nr0b2m1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 4 269.0 g 5.74 11.49 whole body digital scale 0 62913 528
FHH-Lcatm1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70 days-84 days 10 173.7 g 5.15 16.29 whole body digital scale 0 62909 528
FHH-Procm1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70 days-84 days 8 215.38 g 11.16 31.57 whole body digital scale 0 62921 528
FHH-Ccr2m1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 10 260.4 g 3.58 11.32 whole body digital scale 0 62926 528
FHH/EurMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70 days-84 days 6 183.0 g 4.5 11.03 whole body digital scale 0 62940 528
FHH-Ghsrm1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 5 267.0 g 19.31 43.19 whole body digital scale 0 62946 528
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70 days-84 days 5 157.0 g 3.3 7.38 whole body digital scale 0 62963 528
FHH-Egln3m1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70 days-84 days 13 191.77 g 2.68 9.66 whole body digital scale 0 62961 528
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 5 241.6 g 8.86 19.81 whole body digital scale 0 62965 528
SS-Cpt2m1Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 5 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62969 528
SS-Klf4m3Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62972 528
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 71.64 % 6.01 19.93 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62980 528
SS-Cpt2m1Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 1 100.0 % wire myography using a Digi-Med tissue force analysis system with force transducer 0 62984 528
SS-Klf4m3Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 52.0 % 3.62 10.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62983 528
FHH-Nr0b2m1Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 1.22 E-7mole 0.57 0.99 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62988 528
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 1.61 E-7mole 0.29 0.72 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62994 528
FHH-Agtr1bm1Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 4 1.4 E-7mole 0.69 1.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62995 528
FHH-Nr0b2m1Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 4 1.11 E-7mole 0.43 0.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63003 528
FHH-Slc8a2m1Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 13 1.55 E-7mole 0.37 1.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63000 528
FHH-Ccr2m1Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 1.06 E-7mole 0.3 0.73 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63008 528
FHH-F10m2Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 17 5.53 E-7mole 3.97 16.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63013 528
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 1 2.84 E-7mole wire myography using a Digi-Med tissue force analysis system with force transducer 0 63030 528
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 2 0.98 E-7mole 0.28 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63033 528
FHH-Adra1am1Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 1.46 E-7mole 0.6 1.71 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63039 528
FHH-Adra1am1Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 1.62 E-7mole 0.44 1.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63041 528
FHH-Tlr4m1Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 1.41 E-7mole 0.22 0.78 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63042 528
F344-Erbb4Tn(sb-T2/Bart3)2.208Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 1 1.98 E-7mole wire myography using a Digi-Med tissue force analysis system with force transducer 0 63047 528
FHH-Adipoqm2Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 -7.93 null 0.09 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63057 528
SS-Chr 16BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 5 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57303 522
SS-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 1.3 g/mg 0.18 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57314 522
SS-Chr 9BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.53 g/mg 0.18 0.56 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57317 522
SS-Chr 6BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 21 1.51 g/mg 0.13 0.6 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57316 522
FHH-Chr 19BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.49 g/mg 0.05 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57347 522
SS-Chr 16BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 15 0.99 g/mg 0.13 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57355 522
FHH-Chr 8BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.95 g/mg 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57357 522
SS-Chr YBN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 20 1.32 g/mg 0.09 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57371 522
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 20 1.56 g/mg 0.11 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57377 522
FHH-Chr 1BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 26 1.43 g/mg 0.07 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57376 522
SS-Chr 12BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.56 g/mg 0.07 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57385 522
SS-Chr 19BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.82 g/mg 0.14 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57388 522
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 24 2.35 g/mg 0.11 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57395 522
FHH/EurMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 -7.09 null 0.15 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 57409 522
F344/DuCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 20 0.03 umol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57433 522
LEW/Crl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 24 0.05 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57431 522
FHH-Chr 16BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 298.1 g 3.1 9.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55191 522
FHH-Chr 19BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 236.8 g 5.8 18.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55193 522
SS-Chr 13BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 16 215.8 g 4.0 15.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55205 522
SS-Chr 11BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 190.6 g 2.9 9.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55211 522
FHH/EurMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 51 234.9 g 4.6 33.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55212 522
FHH-Chr 1BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 32 235.3 g 3.8 21.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55221 522
SS/JrHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 15 207.8 g 3.3 13.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55225 522
FHH-Chr 11BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 257.6 g 8.2 25.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55226 522
SS.BN-(D8Rat163-D8Rat81)/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 260.1 g 5.2 16.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55237 522
Crl:CD(SD) acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 69.8 % 9.65 30.53 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55386 522
LEW/Crl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 24 72.71 % 3.92 19.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55388 522
SS-Cpt2m1Mcwi serum glucose level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 6 127.0 mg/dl 12.76 31.26 standard blood chemistry panel 0 60614 527
SS/JrHsdMcwi serum glucose level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 17 121.06 mg/dl 2.95 12.18 standard blood chemistry panel 0 60621 527
FHH-Nr0b2m1Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 6 40.55 % 0.62 1.51 automated blood cell counting method 0 60623 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 3 40.4 % 2.95 5.1 automated blood cell counting method 0 60637 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 5 43.6 % 0.74 1.65 automated blood cell counting method 0 60642 527
FHH-Adipoqm2Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 7 50.07 % 2.08 5.51 automated blood cell counting method 0 60643 527
FHH-F10m1Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 11 40.59 % 0.65 2.16 automated blood cell counting method 0 60645 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 1 42.8 % automated blood cell counting method 0 60651 527
FHH-F10m2Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 16 42.78 % 0.51 2.04 automated blood cell counting method 0 60650 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 7 44.84 % 1.03 2.74 automated blood cell counting method 0 60655 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 4 46.13 % 2.06 4.13 automated blood cell counting method 0 60664 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 6 46.27 % 0.79 1.94 automated blood cell counting method 0 60675 527
FHH-Adra1am1Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 9 41.77 % 0.9 2.71 automated blood cell counting method 0 60681 527
FHH-Egln3m1Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 14 41.82 % 0.56 2.09 automated blood cell counting method 0 60688 527
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 41 70.76 U/l 2.74 17.52 standard blood chemistry panel 0 60697 527
BN/NHsdMcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 27 43.7 % 0.34 1.76 automated blood cell counting method 0 60692 527
SS-Cpt2m1Mcwi serum alkaline phosphatase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 6 69.67 U/l 3.86 9.46 standard blood chemistry panel 0 60696 527
SS-Klf4m3Mcwi serum alkaline phosphatase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70 days-84 days 7 54.43 U/l 2.75 7.28 standard blood chemistry panel 0 60699 527
SS-Klf4m3Mcwi serum alkaline phosphatase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 8 83.25 U/l 4.7 13.3 standard blood chemistry panel 0 60700 527
SS-Sod3m1Mcwi blood monocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 10 0.42 x 1000 cells/ul 0.1 0.32 automated blood cell counting method 0 60708 527
SS/JrHsdMcwi blood monocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 41 0.24 x 1000 cells/ul 0.04 0.23 automated blood cell counting method 0 60707 527
SS-Ghsrm3Mcwi blood monocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 2 0.33 x 1000 cells/ul 0.27 0.37 automated blood cell counting method 0 60705 527
SS/JrHsdMcwi blood monocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 17 0.15 x 1000 cells/ul 0.04 0.16 automated blood cell counting method 0 60713 527
SS-Ghsrm3Mcwi serum albumin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70 days-84 days 1 3.6 g/dl standard blood chemistry panel 0 60722 527
SS-Cpt2m1Mcwi serum phosphate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 6 7.75 mg/dl 0.19 0.47 standard blood chemistry panel 0 60726 527
SS-Klf4m3Mcwi serum phosphate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 8 8.44 mg/dl 0.29 0.83 standard blood chemistry panel 0 60730 527
FHH-Adipoqm2Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 7 51.87 fl 0.31 0.82 automated blood cell counting method 0 60755 527
FHH-Nr0b2m1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 10 52.07 fl 0.22 0.7 automated blood cell counting method 0 60751 527
FHH-Htr1am1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 13 54.68 fl 0.75 2.7 automated blood cell counting method 0 60760 527
FHH-Nr4a1m1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 11 54.23 fl 1.01 3.34 automated blood cell counting method 0 60765 527
FHH-Htr1am1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 21 52.41 fl 0.36 1.64 automated blood cell counting method 0 60768 527
FHH-F10m1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 10 51.48 fl 0.31 0.97 automated blood cell counting method 0 60772 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 7 52.87 fl 0.21 0.55 automated blood cell counting method 0 60778 527
FHH/EurMcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 25 53.59 fl 0.31 1.55 automated blood cell counting method 0 60779 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 2 55.8 fl 0.0 0.0 automated blood cell counting method 0 60782 527
FHH-Adipoqm3Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 5 54.04 fl 0.93 2.09 automated blood cell counting method 0 60789 527
F344-AbatTn(sb-T2/Bart3)2.163Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 4 55.7 fl 0.27 0.54 automated blood cell counting method 0 60792 527
FHH-Adra1am1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 9 53.28 fl 0.29 0.87 automated blood cell counting method 0 60793 527
FHH-Adra1am1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 8 51.06 fl 0.21 0.59 automated blood cell counting method 0 60791 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 2 54.85 fl 2.65 3.75 automated blood cell counting method 0 60796 527
FHH-Egln3m1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 14 55.6 fl 0.45 1.69 automated blood cell counting method 0 60800 527
SS-Ghsrm3Mcwi serum bicarbonate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 2 20.0 mmol/l 1.0 1.41 standard blood chemistry panel 0 60807 527
SS/JrHsdMcwi serum bicarbonate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 41 19.34 mmol/l 0.37 2.38 standard blood chemistry panel 0 60809 527
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 -8.49 null 0.13 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55484 522
Hsd:SD concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 16 0.37 10E-7mol/l 0.06 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55503 522
FHH-Procm1Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 8 0.73 x 1000 cells/ul 0.2 0.56 automated blood cell counting method 0 60851 527
FHH-Procm1Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity male 70 days-84 days 9 1.07 x 1000 cells/ul 0.39 1.18 automated blood cell counting method 0 60858 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity male 70 days-84 days 1 1.04 x 1000 cells/ul automated blood cell counting method 0 60867 527
BN-Lcatm3Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 2 1.3 x 1000 cells/ul 0.53 0.74 automated blood cell counting method 0 60872 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity male 70 days-84 days 7 1.3 x 1000 cells/ul 0.15 0.39 automated blood cell counting method 0 60870 527
FHH-Adra1am1Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity male 70 days-84 days 8 0.92 x 1000 cells/ul 0.21 0.59 automated blood cell counting method 0 60883 527
FHH-Adipoqm3Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 6 0.54 x 1000 cells/ul 0.16 0.4 automated blood cell counting method 0 60880 527
FHH-Lcatm1Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 15 1.47 g/dl 0.06 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60921 527
FHH-Nr0b2m1Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70 days-84 days 10 1.5 g/dl 0.08 0.26 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60925 527
FHH-Ccr2m1Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 5 1.58 g/dl 0.09 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60930 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70 days-84 days 3 1.97 g/dl 0.09 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60932 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 4 1.9 g/dl 0.04 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60948 527
FHH-Ghsrm1Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70 days-84 days 12 1.66 g/dl 0.06 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60959 527
FHH-Adra1am1Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 9 1.53 g/dl 0.04 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60967 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 2 2.1 g/dl 0.2 0.28 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60970 527
F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70 days-84 days 7 2.14 g/dl 0.08 0.21 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60975 527
BN/NHsdMcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70 days-84 days 44 1.93 g/dl 0.03 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60977 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 5 1.9 g/dl 0.07 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60976 527
BN/NHsdMcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 27 1.55 g/dl 0.03 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60978 527
SS-Ghsrm3Mcwi hematocrit controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 2 50.3 % 1.4 1.98 automated blood cell counting method 0 60981 527
SS/JrHsdMcwi hematocrit controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 17 46.26 % 0.61 2.53 automated blood cell counting method 0 60989 527
SS-Ghsrm3Mcwi hematocrit controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 1 48.8 % automated blood cell counting method 0 60988 527
BN-Tgfbr2m1Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70 days-84 days 3 0.27 mg/dl 0.03 0.06 automated plasma creatinine analysis 0 60997 527
FHH-Adipoqm2Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70 days-84 days 12 0.28 mg/dl 0.04 0.15 automated plasma creatinine analysis 0 60993 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70 days-84 days 6 0.42 mg/dl 0.09 0.21 automated plasma creatinine analysis 0 61001 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70 days-84 days 3 0.3 mg/dl 0.0 0.0 automated plasma creatinine analysis 0 61005 527
FHH-Nr4a1m1Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70 days-84 days 11 0.24 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 61021 527
SS-Chr 16BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data blood vessel smooth muscle dilation trait female 70 days-84 days 5 99.8 % 0.2 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55716 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.03 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55718 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 -6.26 null 0.09 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55726 522
Hsd:SD acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 69.0 % 6.69 21.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55730 522
Hsd:SD acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 85.5 % 4.86 18.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55731 522
F344-DccTn(sb-T2/Bart3)2.205Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70 days-84 days 6 0.33 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 61043 527
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70 days-84 days 157 0.29 mg/dl 0.01 0.12 automated plasma creatinine analysis 0 61046 527
FHH-Adipoqm1Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70 days-84 days 8 26.38 mmol/l 1.71 4.84 standard blood chemistry panel 0 61081 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70 days-84 days 3 28.0 mmol/l 0.0 0.0 standard blood chemistry panel 0 61086 527
FHH-Nr4a1m1Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait female 70 days-84 days 10 24.3 mmol/l 1.16 3.68 standard blood chemistry panel 0 61101 527
FHH/EurMcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70 days-84 days 154 24.54 mmol/l 0.39 4.82 standard blood chemistry panel 0 61118 527
F344-AbatTn(sb-T2/Bart3)2.163Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70 days-84 days 3 27.33 mmol/l 0.33 0.58 standard blood chemistry panel 0 61123 527
F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70 days-84 days 7 28.14 mmol/l 1.32 3.48 standard blood chemistry panel 0 61129 527
BN/NHsdMcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70 days-84 days 44 23.16 mmol/l 0.45 2.99 standard blood chemistry panel 0 61131 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70 days-84 days 5 26.0 mmol/l 0.55 1.22 standard blood chemistry panel 0 61133 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70 days-84 days 4 25.75 mmol/l 1.25 2.5 standard blood chemistry panel 0 61134 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 1 33.0 g/dl automated blood cell counting method 0 61139 527
FHH-Lcatm1Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 15 33.6 g/dl 0.14 0.54 automated blood cell counting method 0 61147 527
FHH-Agtr1bm1Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 15 33.93 g/dl 0.12 0.45 automated blood cell counting method 0 61143 527
FHH-Adipoqm2Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 7 33.1 g/dl 0.31 0.83 automated blood cell counting method 0 61155 527
FHH-F10m2Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 12 32.78 g/dl 0.15 0.53 automated blood cell counting method 0 61171 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 2 32.45 g/dl 0.25 0.35 automated blood cell counting method 0 61169 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 7 32.34 g/dl 0.17 0.45 automated blood cell counting method 0 61178 527
BN-Lcatm3Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 2 32.8 g/dl 0.1 0.14 automated blood cell counting method 0 61180 527
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 27 32.98 g/dl 0.14 0.7 automated blood cell counting method 0 61204 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 5 32.42 g/dl 0.19 0.43 automated blood cell counting method 0 61202 527
SS-Ghsrm3Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 2 148.5 U/l 56.5 79.9 standard blood chemistry panel 0 61207 527
SS-Sod3m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 10 185.2 U/l 37.4 118.26 standard blood chemistry panel 0 61210 527
SS-Cpt2m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 1 216.0 U/l standard blood chemistry panel 0 61213 527
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 16 174.31 U/l 12.33 49.32 standard blood chemistry panel 0 61215 527
BN-Tgfbr2m1Mcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount female 70 days-84 days 3 5.07 g/dl 0.28 0.49 standard blood chemistry panel 0 61223 527
F344/DuCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 13 1.8 E-7mole 0.32 1.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55981 522
FHH-Slc8a2m1Mcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount female 70 days-84 days 12 5.21 g/dl 0.05 0.19 standard blood chemistry panel 0 61230 527
FHH-F10m1Mcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount male 70 days-84 days 10 5.61 g/dl 0.1 0.31 standard blood chemistry panel 0 61254 527
F344-AbatTn(sb-T2/Bart3)2.163Mcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount male 70 days-84 days 3 5.9 g/dl 0.2 0.35 standard blood chemistry panel 0 61277 527
FHH-Tlr4m1Mcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount female 70 days-84 days 9 5.19 g/dl 0.07 0.2 standard blood chemistry panel 0 61280 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70 days-84 days 1 3.4 mmol/l flame atomic emission spectrometry 0 61293 527
FHH-Tgfbr2m2Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70 days-84 days 12 5.18 mmol/l 0.12 0.41 flame atomic emission spectrometry 0 61292 527
FHH-Adipoqm1Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70 days-84 days 9 4.97 mmol/l 0.14 0.43 flame atomic emission spectrometry 0 61290 527
FHH-Nr0b2m1Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70 days-84 days 10 4.76 mmol/l 0.24 0.75 flame atomic emission spectrometry 0 61305 527
FHH-Agtr1bm1Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70 days-84 days 14 4.05 mmol/l 0.13 0.47 flame atomic emission spectrometry 0 61304 527
FHH-Htr1am1Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70 days-84 days 13 4.85 mmol/l 0.28 1.0 flame atomic emission spectrometry 0 61314 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70 days-84 days 2 4.95 mmol/l 0.65 0.92 flame atomic emission spectrometry 0 61323 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70 days-84 days 4 4.2 mmol/l 0.32 0.65 flame atomic emission spectrometry 0 61330 527
BN-Lcatm3Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70 days-84 days 1 4.6 mmol/l flame atomic emission spectrometry 0 61337 527
FHH-Adipoqm3Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70 days-84 days 6 4.72 mmol/l 0.34 0.84 flame atomic emission spectrometry 0 61342 527
FHH-Nr0b2m1Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 6 5.5 x 1000 cells/ul 0.43 1.06 automated blood cell counting method 0 61361 527
BN-Tgfbr2m1Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 3 7.13 x 1000 cells/ul 0.6 1.04 automated blood cell counting method 0 61367 527
FHH-Tgfbr2m2Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 14 4.66 x 1000 cells/ul 0.43 1.6 automated blood cell counting method 0 61370 527
FHH-F10m2Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 12 4.78 x 1000 cells/ul 0.42 1.44 automated blood cell counting method 0 61397 527
FHH-Egln3m1Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70 days-84 days 6 4.58 x 1000 cells/ul 0.34 0.84 automated blood cell counting method 0 61412 527
F344-AbatTn(sb-T2/Bart3)2.163Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70 days-84 days 3 5.67 x 1000 cells/ul 0.23 0.4 automated blood cell counting method 0 61421 527
FHH-Tlr4m1Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 9 3.71 x 1000 cells/ul 0.3 0.9 automated blood cell counting method 0 61424 527
BN/NHsdMcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70 days-84 days 43 7.07 x 1000 cells/ul 0.29 1.91 automated blood cell counting method 0 61429 527
F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70 days-84 days 7 5.76 x 1000 cells/ul 0.11 0.29 automated blood cell counting method 0 61427 527
FHH-Adipoqm1Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70 days-84 days 9 81.22 U/l 12.71 38.14 standard blood chemistry panel 0 61434 527
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 15 1.66 E-7mole 0.39 1.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54588 522
FHH/EurMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 7 0.92 E-7mole 0.52 1.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54589 522
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 3.86 E-7mole 0.55 1.73 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54592 522
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 -7.4 null 0.12 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54743 522
LEW/Crl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 24 -7.17 null 0.06 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54744 522
LEW/Crl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 24 -6.98 null 0.07 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54749 522
SS-Chr 10BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 61.71 % 7.17 18.97 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54755 522
FHH-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 81.78 % 4.36 13.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54773 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 -8.57 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56023 522
SS-Chr YBN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 -8.7 null 0.08 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56029 522
GH/OmrMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 -8.16 null 0.06 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56036 522
WKY/NCrl body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 15 256.8 g 4.6 17.7 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56068 522
SS-Chr 17BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.05 null 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56100 522
FHH-Chr 16BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -8.01 null 0.1 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56102 522
SS-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.82 null 0.14 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56122 522
FHH-Chr 13BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 13 -8.34 null 0.09 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56127 522
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.7 null 0.17 0.53 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56133 522
SS-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.73 null 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56137 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 21 -8.22 null 0.14 0.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56144 522
SS-Chr XBN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -8.24 null 0.11 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56146 522
FHH-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -8.28 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56140 522
FHH-Chr YBN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 -7.78 null 0.08 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56141 522
SS.BN-(D8Rat163-D8Rat81)/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.98 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56154 522
FHH-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -8.2 null 0.11 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56157 522
SS-Chr XBN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -8.17 null 0.13 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56167 522
FHH-Chr 1BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 26 -7.27 null 0.14 0.73 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56171 522
SS-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.52 null 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56170 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.15 null 0.07 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56181 522
Hsd:SD concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 1.7 E-7mole 0.61 2.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56212 522
SS-Cpt2m1Mcwi serum chloride level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70 days-84 days 6 102.83 mmol/l 0.48 1.17 standard blood chemistry panel 0 62274 527
FHH-Adipoqm1Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70 days-84 days 9 104.22 mmol/l 1.76 5.29 standard blood chemistry panel 0 62284 527
SS/JrHsdMcwi serum chloride level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70 days-84 days 17 103.06 mmol/l 0.78 3.23 standard blood chemistry panel 0 62281 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70 days-84 days 5 95.8 mmol/l 1.74 3.9 standard blood chemistry panel 0 62290 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70 days-84 days 2 99.5 mmol/l 1.5 2.12 standard blood chemistry panel 0 62294 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70 days-84 days 3 103.67 mmol/l 0.67 1.15 standard blood chemistry panel 0 62297 527
FHH-Nr4a1m1Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70 days-84 days 11 105.0 mmol/l 0.62 2.05 standard blood chemistry panel 0 62313 527
FHH-Htr1am1Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70 days-84 days 21 104.76 mmol/l 0.81 3.73 standard blood chemistry panel 0 62316 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70 days-84 days 2 99.0 mmol/l 0.0 0.0 standard blood chemistry panel 0 62330 527
FHH/EurMcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70 days-84 days 158 103.49 mmol/l 0.27 3.39 standard blood chemistry panel 0 62338 527
FHH-Adra1am1Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70 days-84 days 9 104.89 mmol/l 0.54 1.62 standard blood chemistry panel 0 62341 527
FHH-Nr0b2m1Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 6 55.33 mg/dl 3.52 8.62 standard blood chemistry panel 0 62355 527
FHH-Adipoqm2Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 12 52.58 mg/dl 2.18 7.55 standard blood chemistry panel 0 62357 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 3 57.67 mg/dl 2.03 3.51 standard blood chemistry panel 0 62369 527
FHH-F10m1Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 11 53.0 mg/dl 2.66 8.82 standard blood chemistry panel 0 62377 527
FHH-Nr4a1m1Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 11 80.55 mg/dl 5.16 17.11 standard blood chemistry panel 0 62385 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 7 80.71 mg/dl 5.13 13.59 standard blood chemistry panel 0 62387 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 7 67.0 mg/dl 2.28 6.03 standard blood chemistry panel 0 62398 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 1 43.0 mg/dl standard blood chemistry panel 0 62401 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 6 62.33 mg/dl 4.17 10.21 standard blood chemistry panel 0 62407 527
FHH-Egln3m1Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 6 61.17 mg/dl 3.03 7.41 standard blood chemistry panel 0 62406 527
FHH-Adipoqm3Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 5 67.2 mg/dl 4.33 9.68 standard blood chemistry panel 0 62409 527
SS-Klf4m3Mcwi serum total bilirubin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 62432 527
FHH-Tgfbr2m2Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 13 131.46 mg/dl 11.6 41.83 standard blood chemistry panel 0 62450 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 5 253.8 mg/dl 10.75 24.04 standard blood chemistry panel 0 62454 527
FHH-Tgfbr2m2Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 14 137.43 mg/dl 7.74 28.95 standard blood chemistry panel 0 62456 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 2 157.0 mg/dl 12.0 16.97 standard blood chemistry panel 0 62458 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 3 227.33 mg/dl 30.44 52.73 standard blood chemistry panel 0 62461 527
FHH-Lcatm1Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 15 146.13 mg/dl 4.61 17.86 standard blood chemistry panel 0 62459 527
FHH-Chr 17BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 67.0 % 6.65 21.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54780 522
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 87.91 % 3.41 11.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54782 522
FHH-Chr 13BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 72.22 % 6.92 20.77 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54802 522
SS-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 82.11 % 5.21 15.62 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54812 522
SS-Chr YBN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 50.67 % 2.85 12.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54817 522
FHH-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 57.4 % 6.81 21.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54815 522
SS-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 79.75 % 6.46 18.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54818 522
SS-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 63.07 % 5.21 19.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54837 522
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 60.83 % 3.75 15.89 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54840 522
SS-Chr 9BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.09 umol/l 0.03 0.11 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54889 522
FHH-Chr 6BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54891 522
FHH-Chr 6BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54887 522
FHH-Chr 17BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.02 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54906 522
SS-Chr 7BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 11 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54911 522
FHH-Chr 20BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54935 522
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 0.02 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54949 522
FHH-Chr 9BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54962 522
SS-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 16 0.06 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54963 522
SS-Chr 12BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.03 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54965 522
SS-Chr XBN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54968 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 0.04 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56230 522
SS-Chr 16BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.02 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56231 522
SS-Chr 9BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.04 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56233 522
SS-Chr 9BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.05 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56236 522
FHH-Chr 12BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 0.05 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56238 522
GH/OmrMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 0.08 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56245 522
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.11 10E-7mol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56246 522
GH/OmrMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 0.07 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56248 522
BN/NHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 16 0.02 10E-7mol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56253 522
SS-Chr 2BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.17 10E-7mol/l 0.14 0.43 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56255 522
FHH-Chr 1BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 19 0.03 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56254 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 0.05 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56259 522
SS-Chr 9BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 22.6 % 5.26 16.65 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56276 522
SS-Chr 6BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 36.25 % 5.54 15.66 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56275 522
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 26.11 % 3.86 11.59 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56283 522
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 20.38 % 3.17 12.67 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56287 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 40.0 % 4.73 10.58 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56289 522
SS-Chr 16BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 4 21.5 % 1.04 2.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56300 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 99.64 % 0.36 1.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56305 522
SS-Chr 9BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56308 522
SS-Chr YBN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 99.65 % 0.18 0.81 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56316 522
FHH-Chr 1BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 99.33 % 0.35 1.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56319 522
SS.BN-(D8Rat163-D8Rat81)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 99.17 % 0.83 2.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56324 522
SS-Chr 2BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 90.7 % 3.32 10.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56330 522
BN-Lcatm3Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 1 14.0 mmol/l standard blood chemistry panel 0 61645 527
FHH-Adipoqm3Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70 days-84 days 6 17.0 mmol/l 1.21 2.97 standard blood chemistry panel 0 61650 527
FHH/EurMcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 155 17.23 mmol/l 0.29 3.66 standard blood chemistry panel 0 61652 527
FHH-Adra1am1Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 8 14.75 mmol/l 0.92 2.6 standard blood chemistry panel 0 61653 527
F344-AbatTn(sb-T2/Bart3)2.163Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 3 19.67 mmol/l 0.67 1.15 standard blood chemistry panel 0 61657 527
FHH-Lcatm1Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 15 0.19 x 1000 cells/ul 0.04 0.15 automated blood cell counting method 0 61681 527
FHH-F10m1Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 10 0.15 x 1000 cells/ul 0.03 0.11 automated blood cell counting method 0 61706 527
BN-Lcatm3Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 1 0.11 x 1000 cells/ul automated blood cell counting method 0 61717 527
FHH-Adipoqm3Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 6 0.18 x 1000 cells/ul 0.06 0.13 automated blood cell counting method 0 61722 527
FHH-Egln3m1Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 6 0.18 x 1000 cells/ul 0.05 0.13 automated blood cell counting method 0 61720 527
FHH-Adipoqm3Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 5 0.16 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 61723 527
FHH-Adra1am1Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 9 0.1 x 1000 cells/ul 0.03 0.1 automated blood cell counting method 0 61727 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 2 0.21 x 1000 cells/ul 0.15 0.21 automated blood cell counting method 0 61730 527
SS-Klf4m3Mcwi serum potassium level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70 days-84 days 7 4.39 mmol/l 0.22 0.59 flame atomic emission spectrometry 0 61755 527
FHH-Tgfbr2m2Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70 days-84 days 12 140.0 mmol/l 0.44 1.54 flame atomic emission spectrometry 0 61774 527
FHH-Nr0b2m1Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 6 138.33 mmol/l 1.43 3.5 flame atomic emission spectrometry 0 61771 527
FHH-Agtr1bm1Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70 days-84 days 14 141.57 mmol/l 0.59 2.21 flame atomic emission spectrometry 0 61779 527
FHH-Tgfbr2m2Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 14 138.79 mmol/l 0.59 2.23 flame atomic emission spectrometry 0 61780 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 5 140.6 mmol/l 1.63 3.65 flame atomic emission spectrometry 0 61790 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 3 139.33 mmol/l 0.67 1.15 flame atomic emission spectrometry 0 61785 527
FHH-Procm1Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 8 138.75 mmol/l 0.96 2.71 flame atomic emission spectrometry 0 61795 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 1 144.0 mmol/l flame atomic emission spectrometry 0 61799 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 7 141.71 mmol/l 1.48 3.9 flame atomic emission spectrometry 0 61803 527
FHH-Ghsrm1Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 9 139.78 mmol/l 0.57 1.72 flame atomic emission spectrometry 0 61813 527
BN-Lcatm3Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 2 143.0 mmol/l 1.0 1.41 flame atomic emission spectrometry 0 61816 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 2 140.0 mmol/l 1.0 1.41 flame atomic emission spectrometry 0 61818 527
FHH-Adipoqm3Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70 days-84 days 5 135.8 mmol/l 1.93 4.32 flame atomic emission spectrometry 0 61825 527
FHH-Adra1am1Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70 days-84 days 8 141.25 mmol/l 0.77 2.19 flame atomic emission spectrometry 0 61827 527
SS-Klf4m3Mcwi mean corpuscular volume controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 7 60.09 fl 0.42 1.12 automated blood cell counting method 0 61847 527
SS-Klf4m3Mcwi mean corpuscular volume controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70 days-84 days 8 57.94 fl 0.74 2.09 automated blood cell counting method 0 61848 527
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 13 19.69 % 2.95 10.65 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54997 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 42.78 % 4.97 14.92 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55001 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 34.88 % 6.15 17.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54999 522
SS-Chr 20BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 16.0 % 5.83 18.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55072 522
SS-Chr 9BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 25.67 % 5.47 16.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55079 522
SS.BN-(D8Rat163-D8Rat81)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 25.57 % 4.45 11.77 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55094 522
SS-Chr 16BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 37.3 % 5.34 16.88 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55106 522
F344/DuCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 -8.38 null 0.09 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55114 522
LE/BluGill logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -8.48 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55116 522
LE/BluGill logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 -8.28 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55120 522
FHH-Chr 14BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 144.4 g 7.2 22.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55162 522
FHH-Chr 12BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 17 247.3 g 4.9 20.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55173 522
SS-Chr 7BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 8 277.8 g 3.5 9.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55181 522
SS-Chr 17BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 191.7 g 4.4 13.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55183 522
FHH-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.02 E-7mole 0.2 0.59 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56493 522
SS-Chr 6BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 15 2.77 E-7mole 1.53 5.92 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56502 522
FHH-Chr XBN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 1.02 E-7mole 0.09 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56526 522
FHH-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.83 E-7mole 0.28 0.89 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56536 522
SS-Chr 20BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 2.76 E-7mole 0.36 1.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56550 522
FHH-Chr 13BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.56 E-7mole 0.25 0.74 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56542 522
SS-Chr 13BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.93 E-7mole 0.25 0.75 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56554 522
FHH-Chr 1BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 0.84 E-7mole 0.09 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56562 522
SS-Chr 19BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.7 E-7mole 0.22 0.67 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56574 522
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 3.1 E-7mole 0.51 2.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56580 522
SS-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 0.56 E-7mole 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56585 522
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70 days-84 days 3 4.29 x 1000 cells/ul 0.87 1.51 automated blood cell counting method 0 62061 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 3 4.22 x 1000 cells/ul 0.17 0.29 automated blood cell counting method 0 62070 527
FHH-Adipoqm3Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70 days-84 days 6 3.79 x 1000 cells/ul 0.68 1.66 automated blood cell counting method 0 62100 527
F344-AbatTn(sb-T2/Bart3)2.163Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70 days-84 days 4 3.78 x 1000 cells/ul 0.24 0.48 automated blood cell counting method 0 62104 527
FHH-Tlr4m1Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70 days-84 days 9 2.92 x 1000 cells/ul 0.27 0.8 automated blood cell counting method 0 62110 527
BN/NHsdMcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70 days-84 days 27 5.94 x 1000 cells/ul 0.39 2.0 automated blood cell counting method 0 62116 527
FHH-Adipoqm2Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70 days-84 days 12 0.17 mg/dl 0.04 0.14 standard blood chemistry panel 0 62121 527
FHH-Lcatm1Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 13 0.15 mg/dl 0.03 0.1 standard blood chemistry panel 0 62124 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70 days-84 days 2 0.2 mg/dl 0.0 0.0 standard blood chemistry panel 0 62130 527
FHH-Nr0b2m1Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 62135 527
FHH-Procm1Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70 days-84 days 8 0.18 mg/dl 0.03 0.07 standard blood chemistry panel 0 62143 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 1 0.1 mg/dl standard blood chemistry panel 0 62159 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 1 0.1 mg/dl standard blood chemistry panel 0 62165 527
FHH-Adipoqm3Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70 days-84 days 6 0.2 mg/dl 0.0 0.0 standard blood chemistry panel 0 62172 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70 days-84 days 2 0.2 mg/dl 0.0 0.0 standard blood chemistry panel 0 62180 527
BN/NHsdMcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70 days-84 days 27 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 0 62188 527
BN/NHsdMcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 44 0.1 mg/dl 0.0 0.02 standard blood chemistry panel 0 62187 527
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount male 70 days-84 days 41 40.71 U/l 1.32 8.47 standard blood chemistry panel 0 62193 527
SS-Sod3m1Mcwi serum alanine aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70 days-84 days 11 40.18 U/l 4.77 15.81 standard blood chemistry panel 0 62200 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 1 0.0 x 1000 cells/ul automated blood cell counting method 0 62205 527
FHH-Tgfbr2m2Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 14 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 62210 527
FHH-Lcatm1Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 13 0.04 x 1000 cells/ul 0.02 0.07 automated blood cell counting method 0 62206 527
FHH-Lcatm1Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 15 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 62213 527
FHH-Agtr1bm1Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 14 0.06 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 62216 527
BN-Tgfbr2m1Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 7 0.11 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 62218 527
FHH-Adipoqm2Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 7 0.04 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 62221 527
FHH-Htr1am1Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 13 0.06 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 62226 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 1 0.0 x 1000 cells/ul automated blood cell counting method 0 62229 527
FHH-F10m2Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 12 0.04 x 1000 cells/ul 0.02 0.07 automated blood cell counting method 0 62237 527
FHH-Egln3m1Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 6 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 62252 527
FHH-Slc8a2m1Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 9 0.05 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 62263 527
SS-Cyp1a1em5Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 326.5 beats/min 46.5 65.76 radiotelemetry carotid artery 0 - 43708 441
SS-Aldh2em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 364.17 beats/min 7.78 19.06 radiotelemetry carotid artery 0 - 43736 441
SS-Ulk3em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 366.67 beats/min 7.31 12.66 radiotelemetry carotid artery 0 - 43738 441
SS-Nppbem4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 8 1/3 systolic pressure + 2/3 diastolic pressure 132.38 mmHg 4.44 12.56 radiotelemetry carotid artery 0 - 43773 441
SS-Slc30a8em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 137.0 mmHg 2.04 4.08 radiotelemetry carotid artery 0 - 43776 441
SS-Wdr72em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 112.0 mmHg radiotelemetry carotid artery 0 - 43783 441
SS-Stk39em2Mcwi-/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 163.0 mmHg radiotelemetry carotid artery 0 - 43781 441
SS-Ulk3em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 11 1/3 systolic pressure + 2/3 diastolic pressure 140.73 mmHg 4.63 15.36 radiotelemetry carotid artery 0 - 43784 441
SS-Plcd3em4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 135.33 mmHg 5.61 16.82 radiotelemetry carotid artery 0 - 43789 441
SS-Agtr1aem5Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 153.5 mmHg 14.5 20.51 radiotelemetry carotid artery 0 - 43794 441
SS-Cyp1a1em5Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 127.5 mmHg 1.5 2.12 radiotelemetry carotid artery 0 - 43797 441
SS-Wdr72em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 127.5 mmHg 1.5 2.12 radiotelemetry carotid artery 0 - 43809 441
SS-Slc30a8em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 8 1/3 systolic pressure + 2/3 diastolic pressure 134.5 mmHg 3.55 10.03 radiotelemetry carotid artery 0 - 43815 441
SS-Plcd3em4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 143.5 mmHg 17.5 24.75 radiotelemetry carotid artery 0 - 43824 441
SS-Prokr1em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 138.4 mmHg 8.69 19.42 radiotelemetry carotid artery 0 - 43827 441
SS-Nppbem4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 132.67 mmHg 3.26 9.77 radiotelemetry carotid artery 0 - 43835 441
SS-Msraem4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 138.5 mmHg 10.46 20.92 radiotelemetry carotid artery 0 - 43834 441
SS-Tcf7l2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 137.0 mmHg 6.79 13.59 radiotelemetry carotid artery 0 - 43842 441
SS-Cyp1a1em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 131.0 mmHg 14.0 19.8 radiotelemetry carotid artery 0 - 43848 441
SS-Mstnem3Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 144.0 mmHg 6.0 8.49 radiotelemetry carotid artery 0 - 43844 441
SS-Agtr1aem5Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 161.0 mmHg 10.0 14.14 radiotelemetry carotid artery 0 - 43856 441
SS-Agtr1aem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 142.67 mmHg 4.37 13.11 radiotelemetry carotid artery 0 - 43878 441
SS-Kcnq1em14Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 168.0 mmHg radiotelemetry carotid artery 0 - 43885 441
SS-Prokr1em1Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 1 340.0 g whole body digital scale 0 - 43888 441
SS-Agtrapem8Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 10 327.4 g 3.9 12.3 whole body digital scale 0 - 43899 441
SS-Nppbem2Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 4 328.0 g 8.6 17.3 whole body digital scale 0 - 43896 441
LEW/Crl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 57.67 % 4.67 14.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56704 522
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 71.9 % 3.29 10.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56710 522
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 46.3 % 5.64 17.84 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56721 522
LE/BluGill logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 -8.67 null 0.04 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56739 522
Crl:CD(SD) concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.05 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56764 522
Crl:CD(SD) concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.03 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56766 522
LE/BluGill concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 0.08 10E-7mol/l 0.02 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56771 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 43.25 % 7.16 20.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56827 522
LEW/Crl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 39.36 % 4.67 17.46 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56831 522
LE/BluGill hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 37.29 % 4.05 15.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56834 522
FHH-Nr0b2m1Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70 days-84 days 6 17.5 mg/dl 0.89 2.17 standard blood chemistry panel 0 60141 527
FHH-Agtr1bm1Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70 days-84 days 15 20.47 mg/dl 0.71 2.75 standard blood chemistry panel 0 60149 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70 days-84 days 6 21.0 mg/dl 2.25 5.51 standard blood chemistry panel 0 60151 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70 days-84 days 5 21.2 mg/dl 1.56 3.49 standard blood chemistry panel 0 60160 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70 days-84 days 7 19.14 mg/dl 0.88 2.34 standard blood chemistry panel 0 60173 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount male 70 days-84 days 6 143.5 U/l 68.21 167.09 standard blood chemistry panel 0 61443 527
FHH-Nr0b2m1Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount male 70 days-84 days 10 56.8 U/l 4.88 15.43 standard blood chemistry panel 0 61449 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70 days-84 days 5 40.0 U/l 3.27 7.31 standard blood chemistry panel 0 61452 527
FHH-Htr1am1Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70 days-84 days 13 39.54 U/l 6.27 22.59 standard blood chemistry panel 0 61458 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70 days-84 days 1 36.0 U/l standard blood chemistry panel 0 61461 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount male 70 days-84 days 1 63.0 U/l standard blood chemistry panel 0 61473 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70 days-84 days 2 39.5 U/l 4.5 6.36 standard blood chemistry panel 0 61480 527
SS-Cpt2m1Mcwi red blood cell count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 6 8.69 x 10E6 cells/ul 0.18 0.44 automated blood cell counting method 0 61506 527
SS-Klf4m3Mcwi red blood cell count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 7 7.81 x 10E6 cells/ul 0.18 0.48 automated blood cell counting method 0 61509 527
SS/JrHsdMcwi red blood cell count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 17 7.87 x 10E6 cells/ul 0.11 0.46 automated blood cell counting method 0 61513 527
SS-Cpt2m1Mcwi plasma creatinine level controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70 days-84 days 6 0.62 mg/dl 0.11 0.26 automated plasma creatinine analysis 0 61516 527
SS-Sod3m1Mcwi plasma creatinine level controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70 days-84 days 11 0.4 mg/dl 0.04 0.12 automated plasma creatinine analysis 0 61524 527
SS-Cpt2m1Mcwi plasma creatinine level controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70 days-84 days 1 0.8 mg/dl automated plasma creatinine analysis 0 61521 527
FHH-Nr0b2m1Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 10 7.85 mg/dl 0.27 0.86 standard blood chemistry panel 0 61541 527
FHH-Ccr2m1Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount female 70 days-84 days 4 6.65 mg/dl 0.2 0.4 standard blood chemistry panel 0 61546 527
FHH-Htr1am1Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount female 70 days-84 days 13 7.82 mg/dl 0.32 1.16 standard blood chemistry panel 0 61550 527
FHH-F10m2Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 16 9.38 mg/dl 0.79 3.15 standard blood chemistry panel 0 61552 527
FHH-Htr1am1Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 19 7.72 mg/dl 0.14 0.6 standard blood chemistry panel 0 61558 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 1 6.2 mg/dl standard blood chemistry panel 0 61565 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount female 70 days-84 days 4 8.53 mg/dl 1.18 2.35 standard blood chemistry panel 0 61566 527
FHH-Tlr4m1Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 5 8.04 mg/dl 0.37 0.83 standard blood chemistry panel 0 61584 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 5 23.8 mmol/l 0.37 0.84 standard blood chemistry panel 0 61604 527
FHH-Adipoqm1Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 8 15.63 mmol/l 1.19 3.38 standard blood chemistry panel 0 61615 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70 days-84 days 5 21.4 mmol/l 0.68 1.52 standard blood chemistry panel 0 61616 527
F344/NHsd serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 7 20.43 mmol/l 0.75 1.99 standard blood chemistry panel 0 61623 527
FHH-Nr4a1m1Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 11 16.36 mmol/l 0.65 2.16 standard blood chemistry panel 0 61627 527
FHH-F10m1Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 10 17.3 mmol/l 1.02 3.23 standard blood chemistry panel 0 61634 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70 days-84 days 1 23.0 mmol/l standard blood chemistry panel 0 61643 527
SS-Plcd3em4Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 13 310.8 g 5.1 18.4 whole body digital scale 0 - 43914 441
SS-Plcd3em7Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 11 291.4 g 3.7 12.3 whole body digital scale 0 - 43926 441
SS-Sh2b3em2Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 9 303.9 g 4.5 13.4 whole body digital scale 0 - 43930 441
SS-Plod1em1Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 5 307.2 g 14.7 32.9 whole body digital scale 0 - 43933 441
SS-Aldh2em2Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 6 92.17 mg/d 9.55 23.4 automated urine analysis 0 - 43984 441
SS-Cyp1a1em1Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 7 72.43 mg/d 9.46 25.04 automated urine analysis 0 - 43992 441
SS-Agtr1aem1Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 9 110.26 mg/d 23.02 69.07 automated urine analysis 0 - 44002 441
SS-Tcf7l2em1Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 10 145.98 mg/d 12.98 41.04 automated urine analysis 0 - 44003 441
SS-Nppaem4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 10 343.31 beats/min 5.47 17.3 radiotelemetry carotid artery 0 - 44011 441
SS-Plcd3em4Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 3 145.77 mg/d 15.03 26.03 automated urine analysis 0 - 44010 441
SS-Prokr1em2Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 5 359.0 beats/min 7.2 16.11 radiotelemetry carotid artery 0 - 44013 441
SS-Stk39em2Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 363.0 beats/min 2.89 5.0 radiotelemetry carotid artery 0 - 44014 441
SS-Cyp1a1em5Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 352.0 beats/min 12.0 16.97 radiotelemetry carotid artery 0 - 44018 441
SS-Cdh13em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 348.0 beats/min 19.15 38.3 radiotelemetry carotid artery 0 - 44023 441
SS-Ulk3em1Mcwi-/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 350.33 beats/min 7.31 12.66 radiotelemetry carotid artery 0 - 44026 441
SS-Agtr1aem5Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 376.5 beats/min 12.5 17.68 radiotelemetry carotid artery 0 - 44042 441
SS-Prokr1em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 317.0 beats/min 24.82 49.65 radiotelemetry carotid artery 0 - 44044 441
SS-Msraem3Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 374.0 beats/min 14.0 19.8 radiotelemetry carotid artery 0 - 44069 441
SS-Agtr1aem1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 134.5 mmHg 6.66 16.32 radiotelemetry carotid artery 0 - 44074 441
SS-Plekha7em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 137.17 mmHg 4.8 11.75 radiotelemetry carotid artery 0 - 44079 441
SS-Agtrapem8Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 8 1/3 systolic pressure + 2/3 diastolic pressure 122.68 mmHg 3.35 9.48 radiotelemetry carotid artery 0 - 44084 441
SS-Plekha7em4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 11 1/3 systolic pressure + 2/3 diastolic pressure 143.36 mmHg 3.15 10.45 radiotelemetry carotid artery 0 - 44100 441
SS-Mstnem3Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 7 1/3 systolic pressure + 2/3 diastolic pressure 132.14 mmHg 5.47 14.47 radiotelemetry carotid artery 0 - 44109 441
SS-Plekha7em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 146.78 mmHg 5.63 16.9 radiotelemetry carotid artery 0 - 44103 441
SS-Plod1em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 145.75 mmHg 6.05 12.09 radiotelemetry carotid artery 0 - 44117 441
SS-Agtr1aem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 134.67 mmHg 4.68 14.03 radiotelemetry carotid artery 0 - 44125 441
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 99.29 % 0.27 0.99 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56851 522
F344/DuCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 99.71 % 0.29 1.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56854 522
LE/BluGill sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56856 522
LEW/Crl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 25 1.65 g/mg 0.08 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56862 522
F344/DuCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 99.91 % 0.09 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56859 522
Crl:CD(SD) maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.47 g/mg 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56865 522
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 0.19 umol/l 0.07 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56883 522
Hsd:SD hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 13 48.4 % 6.98 25.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 56887 522
SS-Chr 9BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -6.88 null 0.09 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56898 522
SS-Chr 9BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.54 null 0.09 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56903 522
FHH-Chr 12BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 -6.99 null 0.11 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56905 522
SS-Chr 10BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 7 -6.41 null 0.07 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56906 522
FHH-Chr 10BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -6.8 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56923 522
SS-Chr 16BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -6.8 null 0.22 0.82 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56930 522
SS-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.72 null 0.1 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56932 522
SS-Chr YBN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -6.98 null 0.04 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56952 522
SS-Chr 19BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 -6.72 null 0.03 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56965 522
FHH-Chr 7BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -6.96 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56970 522
SS-Chr 16BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.17 g/mg 0.15 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56989 522
GH/OmrMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.0 g/mg 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56993 522
FHH-Slc8a2m1Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70 days-84 days 10 22.4 mg/dl 0.62 1.96 standard blood chemistry panel 0 60203 527
BN/NHsdMcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70 days-84 days 44 25.52 mg/dl 0.63 4.17 standard blood chemistry panel 0 60209 527
BN/NHsdMcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70 days-84 days 27 24.59 mg/dl 0.82 4.27 standard blood chemistry panel 0 60210 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 1 9.8 mg/dl standard blood chemistry panel 0 60217 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 5 10.26 mg/dl 0.15 0.34 standard blood chemistry panel 0 60220 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 6 10.63 mg/dl 0.08 0.19 standard blood chemistry panel 0 60223 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount female 70 days-84 days 2 9.9 mg/dl 0.1 0.14 standard blood chemistry panel 0 60224 527
F344/NHsd serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 7 9.64 mg/dl 0.12 0.3 standard blood chemistry panel 0 60239 527
FHH-Ccr2m1Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 8 9.94 mg/dl 0.13 0.36 standard blood chemistry panel 0 60242 527
FHH-Nr4a1m1Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount female 70 days-84 days 11 9.95 mg/dl 0.14 0.46 standard blood chemistry panel 0 60251 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 1 8.7 mg/dl standard blood chemistry panel 0 60253 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount female 70 days-84 days 4 10.03 mg/dl 0.51 1.01 standard blood chemistry panel 0 60252 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 7 10.4 mg/dl 0.22 0.58 standard blood chemistry panel 0 60256 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount female 70 days-84 days 2 10.3 mg/dl 0.2 0.28 standard blood chemistry panel 0 60260 527
FHH-Ghsrm1Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 15 9.82 mg/dl 0.13 0.48 standard blood chemistry panel 0 60263 527
FHH-Adipoqm3Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount female 70 days-84 days 6 9.95 mg/dl 0.14 0.34 standard blood chemistry panel 0 60266 527
FHH-Adra1am1Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 8 9.8 mg/dl 0.21 0.6 standard blood chemistry panel 0 60269 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70 days-84 days 5 10.66 mg/dl 0.16 0.36 standard blood chemistry panel 0 60283 527
FHH-Htr1am1Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 13 13.52 g/dl 0.18 0.64 automated blood cell counting method 0 60320 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 3 13.7 g/dl 0.46 0.79 automated blood cell counting method 0 60318 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 7 14.64 g/dl 0.33 0.88 automated blood cell counting method 0 60327 527
FHH-Procm1Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 9 15.79 g/dl 1.01 3.03 automated blood cell counting method 0 60326 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 4 14.78 g/dl 0.24 0.48 automated blood cell counting method 0 60334 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 7 15.43 g/dl 0.14 0.38 automated blood cell counting method 0 60338 527
BN-Lcatm3Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 2 14.6 g/dl 0.1 0.14 automated blood cell counting method 0 60340 527
FHH-Tlr4m1Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 7 16.21 g/dl 0.84 2.23 automated blood cell counting method 0 60354 527
FHH-Adra1am1Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 8 14.59 g/dl 0.27 0.78 automated blood cell counting method 0 60351 527
FHH-Egln3m1Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 14 13.56 g/dl 0.18 0.66 automated blood cell counting method 0 60360 527
SS-Cpt2m1Mcwi mean corpuscular hemoglobin controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 1 18.7 pg automated blood cell counting method 0 60373 527
SS/JrHsdMcwi mean corpuscular hemoglobin controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 17 19.45 pg 0.1 0.41 automated blood cell counting method 0 60375 527
FHH-Lcatm1Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 13 264.23 U/l 10.78 38.85 standard blood chemistry panel 0 60392 527
SS/JrHsdMcwi serum globulin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70 days-84 days 41 2.14 g/dl 0.03 0.22 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 61865 527
SS-Klf4m3Mcwi serum globulin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70 days-84 days 8 2.26 g/dl 0.07 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 61868 527
SS-Sod3m1Mcwi serum globulin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 11 1.91 g/dl 0.06 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 61872 527
SS-Klf4m3Mcwi blood hemoglobin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 8 14.98 g/dl 0.28 0.78 automated blood cell counting method 0 61878 527
SS-Klf4m3Mcwi blood hemoglobin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 7 14.91 g/dl 0.35 0.92 automated blood cell counting method 0 61877 527
SS/JrHsdMcwi blood hemoglobin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 17 15.31 g/dl 0.22 0.89 automated blood cell counting method 0 61881 527
SS/JrHsdMcwi plasma anion gap controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait female 70 days-84 days 17 24.94 mmol/l 0.54 2.22 standard blood chemistry panel 0 61891 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount male 70 days-84 days 1 4.1 g/dl standard blood chemistry panel 0 61897 527
BN-Tgfbr2m1Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70 days-84 days 3 3.57 g/dl 0.2 0.35 standard blood chemistry panel 0 61899 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70 days-84 days 2 3.75 g/dl 0.05 0.07 standard blood chemistry panel 0 61904 527
FHH-Slc8a2m1Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70 days-84 days 12 3.81 g/dl 0.03 0.09 standard blood chemistry panel 0 61906 527
FHH-Ccr2m1Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70 days-84 days 5 3.7 g/dl 0.03 0.07 standard blood chemistry panel 0 61914 527
FHH-Ccr2m1Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount male 70 days-84 days 8 3.81 g/dl 0.04 0.11 standard blood chemistry panel 0 61922 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount male 70 days-84 days 7 3.89 g/dl 0.05 0.12 standard blood chemistry panel 0 61936 527
FHH-Adra1am1Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount male 70 days-84 days 8 3.76 g/dl 0.05 0.15 standard blood chemistry panel 0 61949 527
F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount male 70 days-84 days 7 3.9 g/dl 0.09 0.24 standard blood chemistry panel 0 61959 527
FHH-Lcatm1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 13 213.62 U/l 31.65 114.12 standard blood chemistry panel 0 61970 527
FHH-Adipoqm1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 9 224.44 U/l 23.7 71.09 standard blood chemistry panel 0 61966 527
BN-Tgfbr2m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 3 166.33 U/l 18.66 32.32 standard blood chemistry panel 0 61971 527
FHH-Tgfbr2m2Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 14 207.64 U/l 12.63 47.24 standard blood chemistry panel 0 61974 527
FHH-Slc8a2m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 12 185.58 U/l 18.35 63.58 standard blood chemistry panel 0 61978 527
FHH-Htr1am1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 13 184.54 U/l 17.67 63.71 standard blood chemistry panel 0 61990 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 7 232.29 U/l 21.33 56.43 standard blood chemistry panel 0 61997 527
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 1 278.0 U/l standard blood chemistry panel 0 62005 527
FHH-Nr4a1m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 11 157.45 U/l 9.95 33.02 standard blood chemistry panel 0 62003 527
FHH/EurMcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 25 190.28 U/l 26.43 132.17 standard blood chemistry panel 0 62009 527
FHH/EurMcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 158 230.06 U/l 18.8 236.33 standard blood chemistry panel 0 62020 527
FHH-Slc8a2m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 10 240.3 U/l 15.59 49.29 standard blood chemistry panel 0 62027 527
FHH-Egln3m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 14 216.86 U/l 23.35 87.37 standard blood chemistry panel 0 62030 527
FHH-Tlr4m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 9 216.22 U/l 21.38 64.14 standard blood chemistry panel 0 62028 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 4 190.5 U/l 32.26 64.53 standard blood chemistry panel 0 62036 527
SS-Klf4m3Mcwi blood lymphocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 8 6.87 x 1000 cells/ul 0.78 2.2 automated blood cell counting method 0 62042 527
FHH-Lcatm1Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 13 3.51 x 1000 cells/ul 0.35 1.27 automated blood cell counting method 0 62052 527
SS-Plcd3em4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 135.33 mmHg 13.32 23.07 radiotelemetry carotid artery 0 - 44133 441
SS-Agtr1aem1Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 6 10.49 mg/d 0.59 1.44 automated urine analysis 0 - 44135 441
SS-Kcnq1em14Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 7 7.87 mg/d 0.42 1.12 automated urine analysis 0 - 44139 441
SS-Nppaem4Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 11 10.15 mg/d 0.31 1.01 automated urine analysis 0 - 44134 441
SS-Cyp1a1em5Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 2 9.3 mg/d 1.15 1.62 automated urine analysis 0 - 44141 441
SS-Slc30a8em1Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 4 14.02 mg/d 0.87 1.73 automated urine analysis 0 - 44147 441
SS-Stk39em2Mcwi-/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 1 9.13 mg/d automated urine analysis 0 - 44152 441
SS-Plekha7em4Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 2 10.11 mg/d 0.61 0.86 automated urine analysis 0 - 44159 441
SS-Prokr1em2Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 8 10.42 mg/d 0.59 1.67 automated urine analysis 0 - 44163 441
SS-Plekha7em4Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 12 10.0 mg/d 0.75 2.6 automated urine analysis 0 - 44161 441
SS-Plod1em1Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 12 9.0 mg/d 0.42 1.45 automated urine analysis 0 - 44162 441
SS-Cyp1a1em5Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 2 9.62 mg/d 0.34 0.47 automated urine analysis 0 - 44168 441
SS-Plcd3em7Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 3 9.91 mg/d 0.94 1.63 automated urine analysis 0 - 44174 441
SS-Plcd3em7Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 10 9.4 mg/d 0.63 2.0 automated urine analysis 0 - 44172 441
SS-Msraem3Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 2 11.16 mg/d 0.97 1.37 automated urine analysis 0 - 44175 441
SS-Slc30a8em2Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 1 10.77 mg/d automated urine analysis 0 - 44182 441
SS-Slc30a8em1Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 9 11.01 mg/d 0.53 1.58 automated urine analysis 0 - 44186 441
SS-Nppbem4Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 9 12.05 mEq/d 0.75 2.26 automated urine analysis 0 - 44206 441
SS-Stk39em2Mcwi-/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 1 9.46 mEq/d automated urine analysis 0 - 44214 441
SS-Wdr72em1Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 1 12.63 mEq/d automated urine analysis 0 - 44216 441
SS-Plekha7em4Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 2 11.67 mEq/d 1.11 1.57 automated urine analysis 0 - 44221 441
SS-Mstnem3Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 8 10.54 mEq/d 0.88 2.48 automated urine analysis 0 - 44232 441
SS-Wdr72em1Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 2 11.21 mEq/d 0.0 0.0 automated urine analysis 0 - 44242 441
SS-Msraem3Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 2 10.64 mEq/d 1.7 2.41 automated urine analysis 0 - 44237 441
SS-Tcf7l2em1Mcwi-/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 2 12.34 mEq/d 1.25 1.76 automated urine analysis 0 - 44245 441
SS-Slc30a8em2Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 11 10.43 mEq/d 0.56 1.84 automated urine analysis 0 - 44253 441
SS-Tcf7l2em1Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 10 9.71 mEq/d 0.94 2.98 automated urine analysis 0 - 44250 441
SS-Nppaem4Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 12 25.37 mg/d 2.78 9.62 automated urine analysis 0 - 44258 441
SS-Mstnem1Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 3 10.27 mEq/d 0.43 0.75 automated urine analysis 0 - 44251 441
SS-Agtr1aem1Mcwi+/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 6 50.27 mg/d 20.21 49.51 automated urine analysis 0 - 44259 441
SS-Msraem4Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 7 43.19 mg/d 7.88 20.85 automated urine analysis 0 - 44272 441
SS-Mstnem3Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 3 24.79 mg/d 3.02 5.23 automated urine analysis 0 - 44277 441
SS-Mstnem3Mcwi+/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 8 32.1 mg/d 1.62 4.58 automated urine analysis 0 - 44294 441
SS-Plcd3em7Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 10 59.6 mg/d 8.7 27.51 automated urine analysis 0 - 44296 441
SS-Slc30a8em2Mcwi+/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 1 11.57 mg/d automated urine analysis 0 - 44306 441
SS-Nppbem2Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 16 58.99 mg/d 9.31 37.24 automated urine analysis 0 - 44309 441
SS-Nppaem4Mcwi+/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 2 67.01 mg/d 4.01 5.68 automated urine analysis 0 - 44317 441
SS-Kcnq1em14Mcwi+/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 1 89.9 mg/d automated urine analysis 0 - 44318 441
SS-Nppbem2Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 4 1.49 g 0.04 0.08 digital scale post excision weight measurement 0 - 44328 441
Hsd:SD maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 16 1.37 g/mg 0.23 0.92 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57114 522
SS-Chr 16BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 64.0 % 4.65 14.7 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57137 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 40 54.13 % 2.52 15.94 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57149 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 50.0 % 6.77 15.13 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57153 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 43.77 % 9.19 24.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57158 522
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70 days-84 days 5 106.8 U/l 4.1 9.18 standard blood chemistry panel 0 60406 527
FHH-Adipoqm2Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 7 290.43 U/l 19.11 50.57 standard blood chemistry panel 0 60407 527
FHH-F10m1Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 10 204.9 U/l 12.09 38.22 standard blood chemistry panel 0 60424 527
FHH/EurMcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70 days-84 days 25 143.96 U/l 8.55 42.73 standard blood chemistry panel 0 60431 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 1 143.0 U/l standard blood chemistry panel 0 60433 527
FHH-Adipoqm3Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 5 182.4 U/l 38.74 86.62 standard blood chemistry panel 0 60441 527
FHH-Adra1am1Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70 days-84 days 9 145.89 U/l 11.53 34.58 standard blood chemistry panel 0 60445 527
FHH-Agtr1bm1Mcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 15 17.45 pg 0.1 0.37 automated blood cell counting method 0 60467 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 2 18.0 pg 0.0 0.0 automated blood cell counting method 0 60470 527
FHH-Nr4a1m1Mcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 11 17.89 pg 0.1 0.34 automated blood cell counting method 0 60489 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 1 17.6 pg automated blood cell counting method 0 60505 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 3 18.0 pg 0.15 0.26 automated blood cell counting method 0 60508 527
BN/NHsdMcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 27 17.76 pg 0.07 0.39 automated blood cell counting method 0 60528 527
SS-Klf4m3Mcwi serum total cholesterol level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 8 92.25 mg/dl 9.86 27.88 standard blood chemistry panel 0 60536 527
FHH-Tgfbr2m2Mcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 13 8.55 x 10E6 cells/ul 0.1 0.35 automated blood cell counting method 0 60544 527
FHH-F10m2Mcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 12 7.6 x 10E6 cells/ul 0.15 0.51 automated blood cell counting method 0 60577 527
FHH-Ghsrm1Mcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 15 8.62 x 10E6 cells/ul 0.1 0.39 automated blood cell counting method 0 60591 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 6 8.62 x 10E6 cells/ul 0.19 0.46 automated blood cell counting method 0 60593 527
FHH-Adipoqm3Mcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 6 7.73 x 10E6 cells/ul 0.13 0.31 automated blood cell counting method 0 60594 527
SS-Cyp1a1em1Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 3 1.46 g 0.06 0.11 digital scale post excision weight measurement 0 - 44342 441
SS-Plekha7em4Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 12 1.33 g 0.05 0.16 digital scale post excision weight measurement 0 - 44347 441
SS-Plekha7em1Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 9 1.41 g 0.04 0.12 digital scale post excision weight measurement 0 - 44350 441
SS-Prokr1em1Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.46 g 0.04 0.08 digital scale post excision weight measurement 0 - 44353 441
SS-Aldh2em2Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 6 1.62 g 0.15 0.36 digital scale post excision weight measurement 0 - 44359 441
SS-Aldh2em2Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 6 1.42 g 0.04 0.1 digital scale post excision weight measurement 0 - 44355 441
SS-Mstnem3Mcwi-/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 129.0 mmHg radiotelemetry carotid artery 0 - 44406 441
SS-Agtr1aem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 131.89 mmHg 4.34 13.02 radiotelemetry carotid artery 0 - 44434 441
SS-Msraem3Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 143.33 mmHg 10.53 18.23 radiotelemetry carotid artery 0 - 44439 441
SS-Msraem4Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 7 1.43 g 0.05 0.14 digital scale post excision weight measurement 0 - 44457 441
SS-Tcf7l2em1Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.45 g 0.07 0.16 digital scale post excision weight measurement 0 - 44460 441
SS-Plekha7em1Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 9 1.38 g 0.03 0.1 digital scale post excision weight measurement 0 - 44473 441
SS-Cyp1a1em2Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 3 1.55 g 0.07 0.11 digital scale post excision weight measurement 0 - 44466 441
SS-Wdr72em1Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 2 1.56 g 0.08 0.11 digital scale post excision weight measurement 0 - 44489 441
SS-Nppbem2Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 16 1.49 g 0.04 0.14 digital scale post excision weight measurement 0 - 44494 441
SS-Mstnem1Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 3 1.67 g 0.06 0.11 digital scale post excision weight measurement 0 - 44498 441
SS-Prokr1em2Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 7 1.12 g 0.03 0.08 digital scale post excision weight measurement 0 - 44507 441
SS-Cyp1a1em5Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 2 1.1 g 0.05 0.07 digital scale post excision weight measurement 0 - 44512 441
SS-Stk39em2Mcwi-/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 1 1.17 g digital scale post excision weight measurement 0 - 44523 441
SS-Wdr72em1Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 1 1.0 g digital scale post excision weight measurement 0 - 44525 441
SS-Ulk3em1Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 11 1.09 g 0.02 0.07 digital scale post excision weight measurement 0 - 44526 441
SS-Plcd3em4Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 13 1.1 g 0.02 0.05 digital scale post excision weight measurement 0 - 44531 441
SS-Plod1em1Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 12 1.14 g 0.03 0.09 digital scale post excision weight measurement 0 - 44533 441
SS-Prokr1em2Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 8 1.18 g 0.05 0.14 digital scale post excision weight measurement 0 - 44534 441
SS-Plekha7em4Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 13 1.04 g 0.03 0.12 digital scale post excision weight measurement 0 - 44532 441
SS-Cyp1a1em5Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 2 1.09 g 0.04 0.06 digital scale post excision weight measurement 0 - 44539 441
SS-Cdh13em1Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 8 1.09 g 0.04 0.11 digital scale post excision weight measurement 0 - 44561 441
SS-Kcnq1em14Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 1 1.24 g digital scale post excision weight measurement 0 - 44565 441
SS-Nppbem4Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 9 352.56 beats/min 9.85 29.56 radiotelemetry carotid artery 0 - 44577 441
SS-Mstnem3Mcwi-/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 358.0 beats/min radiotelemetry carotid artery 0 - 44591 441
SS-Plcd3em4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 11 338.73 beats/min 9.57 31.74 radiotelemetry carotid artery 0 - 44593 441
SS-Plcd3em7Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 358.0 beats/min radiotelemetry carotid artery 0 - 44607 441
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 7 362.0 beats/min 6.26 16.56 radiotelemetry carotid artery 0 - 44610 441
SS-Nppbem2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 14 354.71 beats/min 6.54 24.45 radiotelemetry carotid artery 0 - 44617 441
SS-Slc30a8em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 8 355.5 beats/min 12.21 34.53 radiotelemetry carotid artery 0 - 44618 441
SS-Mstnem1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 348.0 beats/min 14.73 25.51 radiotelemetry carotid artery 0 - 44621 441
SS-Slc30a8em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 11 365.55 beats/min 5.98 19.84 radiotelemetry carotid artery 0 - 44623 441
SS-Tcf7l2em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 9 364.33 beats/min 7.03 21.08 radiotelemetry carotid artery 0 - 44620 441
SS-Stk39em2Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 390.75 beats/min 5.5 11.0 radiotelemetry carotid artery 0 - 44631 441
SS-Plekha7em4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 11 385.73 beats/min 6.12 20.31 radiotelemetry carotid artery 0 - 44655 441
SS-Prokr1em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 7 364.29 beats/min 8.64 22.86 radiotelemetry carotid artery 0 - 44657 441
SS-Plcd3em7Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 347.0 beats/min radiotelemetry carotid artery 0 - 44668 441
SS-Ulk3em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 372.67 beats/min 5.78 10.02 radiotelemetry carotid artery 0 - 44665 441
SS-Agtrapem8Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 365.5 beats/min 0.5 0.71 radiotelemetry carotid artery 0 - 44674 441
SS-Kcnq1em14Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 382.0 beats/min radiotelemetry carotid artery 0 - 44687 441
SS-Plcd3em4Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 368.0 beats/min 26.27 45.51 radiotelemetry carotid artery 0 - 44688 441
SS/Hsd cubic root of body weight to nasoanal length ratio controlled sodium content diet (0.3 %) then fasting (for 16 hours) Herrera VL, et al., Circ Res 2004 Mar 5; 94(4):446-52 body mass male 180 days 20 315.4 g/mm x 10000 1.87 8.36 body weighing method 0.0 0 67893 204
SS.LEW-(D10Got112-Igfbp4)/Ayd heart left atrium end-systolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left atrium diameter male 77 days 5 4.66 mm 0.11 0.24 transthoracic echocardiography 0.0 0 68304 542
SS.LEW-(D16Chm36-D16Mit2)/Ayd heart left atrium end-systolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left atrium diameter male 77 days 18 4.65 mm 0.14 0.6 transthoracic echocardiography 0.0 0 68302 542
SS.LEW-(D10Got112-Igfbp4)/Ayd heart left atrium end-diastolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left atrium diameter male 77 days 5 3.13 mm 0.24 0.53 transthoracic echocardiography 0.0 0 68312 542
SS.LEW-(D5Mco39-D5Mco41)(D5Mco42-D5Mco47)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Pillai R, et al., Physiol Genomics. 2013 Aug 15;45(16):729-36. doi: 10.1152/physiolgenomics.00077.2013. Epub 2013 Jun 11. arterial blood pressure trait male 62 days-66 days 0 157.0 mmHg 4.3 tail cuff plethysmography 0.0 0 restrained, 28 degrees C 70595 1482
SR/JrHsd systolic blood pressure controlled sodium content diet (8 %) (between 83 and 84 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait female 167 days-168 days 5 120.8 mmHg 3.4 7.6 intra-aortic abdominal radiotelemetry 0.0 0 67858 810
SS.LEW-(D17Chm131-D17Chm93)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 129.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70443 1438
SS.LEW-(D17Chm131-D17Chm93)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 137.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70444 1438
SS.LEW-(D18Chm41-D18Rat92)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 124.0 mmHg 4.0 8.94 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70448 1438
SS.LEW-(Prlr-D2Rat143)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 184.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70474 1438
SS.MNS-(D2Got93-D2Rat222)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 10 163.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70476 1438
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 112 days 18 199.0 mmHg 0.24 1.0 tail cuff plethysmography 0.0 0 69130 1126
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 126 days 18 188.0 mmHg 2.83 12.0 tail cuff plethysmography 0.0 0 69131 1126
SS mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 12 178.0 mmHg 4.0 13.86 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70466 1438
SS/JrSeac heart left ventricle end-systolic posterior wall thickness controlled sodium content diet (8 %) (for 35 days) Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. heart left ventricle wall thickness not specified 77 days 5 2.1 mm 0.21 0.46 transthoracic echocardiography 0.0 0 End-systole posterior wall thickening 68584 733
SS/JrSeac heart left ventricle end-systolic posterior wall thickness controlled sodium content diet (0.3 %) (for 84 days) Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. heart left ventricle wall thickness not specified 126 days 5 1.24 mm 0.16 0.36 transthoracic echocardiography 0.0 0 End-systole posterior wall thickening 68585 733
SS/JrSeac heart rate controlled sodium content diet (0.3 %) (for 35 days) then controlled oxygen content Kreb's solution perfusate Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. heart pumping trait not specified 77 days 5 264.0 beats/min 37.12 83.0 isolated perfused heart method 0.0 0 68591 733
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 118.9 mmHg 4.4 19.68 vascular indwelling catheter method left femoral artery 120.0 0 69529 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 120.4 mmHg 5.3 24.29 vascular indwelling catheter method left femoral artery 120.0 0 69535 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 159.0 mmHg 7.1 21.3 vascular indwelling catheter method left femoral artery 120.0 0 69546 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 160.0 mmHg 6.7 20.1 vascular indwelling catheter method left femoral artery 120.0 0 69548 151
SS/Jr peak aortic velocity controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. aorta blood flow trait male 77 days 40 110.5 cm/s 2.59 16.4 pulsed wave doppler ultrasound 0.0 0 peak aortic velocity 68242 542
SS.LEW-(D18Rat29-D18Rat55)/Ayd heart left ventricle anterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle anterior wall thickness male 77 days 11 0.18 mm 0.01 0.02 transthoracic echocardiography 0.0 0 68251 542
SS.LEW-(D18Rat29-D18Rat55)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle mass male 77 days 11 2.75 mg/g 0.11 0.37 post excision weight measurement 0.0 0 68259 542
SS.LEW-(D3Rat52-D3Chm57)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle mass male 77 days 8 2.69 mg/g 0.09 0.26 post excision weight measurement 0.0 0 68264 542
SS/Jr heart left ventricle end-systolic area controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart left ventricle size trait not specified 0 days 6 0.25 cm2 0.07 0.17 echocardiography 0.0 0 69602 749
SS/Jr age at time of death controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 66 and 68 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total life span not specified 0 days 8 median 108.0 d necropsy 0.0 0 visual observation 69608 749
SS/JrHsd pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 8 57.1 mmHg 0.4 1.13 intra-aortic abdominal radiotelemetry 0.0 0 70504 1458
SS.MNS-(D2Rat183-D2Chm113)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 12 136.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70480 1438
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 16 177.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 68086 830
SHRSR/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 126 days 18 89.0 mg/d 2.12 9.0 Bradford protein assay 0.0 0 69214 1126
SHRSR/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 112 days 18 80.0 mg/d 1.06 4.5 Bradford protein assay 0.0 0 69213 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 112 days 29 241.0 mg/d 4.09 22.0 Bradford protein assay 0.0 0 69224 1126
BN/NHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 92 days-94 days 25 9.86 ml/d 0.4 2.0 urine volume measurement method 0.0 0 needs ml/d default 69464 151
SS/JrHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92 days-94 days 16 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 0 mg/min 69478 151
BN/NHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 92 days-94 days 8 1.1 ml/min 0.2 0.57 urine creatinine analysis 0.0 0 mg/min 69479 151
SS/JrHsdMcwi hematocrit controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. erythrocyte quantity female 89 days-92 days 15 38.8 % 1.4 5.42 hematocrit analysis 0.0 0 69482 151
LEW heart left ventricle end-diastolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle end-diastolic diameter male 77 days 14 7.16 mm 0.25 0.93 transthoracic echocardiography 0.0 0 heart left ventricle anterior wall thickness 68265 542
SS.LEW-(D18Chm41-D18Rat92)/Ayd heart left ventricle end-diastolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle end-diastolic diameter male 77 days 8 7.36 mm 0.1 0.27 transthoracic echocardiography 0.0 0 68268 542
SS.LEW-(D16Chm36-D16Mit2)/Ayd heart left ventricle end-systolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle end-systolic diameter male 77 days 18 4.35 mm 0.18 0.76 transthoracic echocardiography 0.0 0 68277 542
BN/NHsdMcwi plasma total protein level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood total protein amount female 89 days-92 days 13 38.6 mg/ml 2.0 7.21 unspecified method 0.0 0 69483 151
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) and controlled tempol content drinking water (0.5 mmol/l) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 42 days 4 157.3 pg/ml 45.2 90.4 radioimmunoassay 0.0 0 69654 736
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 31 60.0 mg/d 2.51 14.0 Bradford protein assay 0.0 0 70251 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 98 days 31 81.0 mg/d 4.13 23.0 Bradford protein assay 0.0 0 70246 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 33 38.0 mg/d 1.91 11.0 Bradford protein assay 0.0 0 70257 1126
SS/JrSeac myocardial flow rate controlled sodium content diet (8 %) (for 35 days) then controlled oxygen content Kreb's solution perfusate (for 0.2 hours) then 99mTc-sestamibi (37 MBq/l) (for 0.3 hours) then controlled oxygen content Kreb's solution perfusate (for 0.4 hours) Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. coronary blood flow trait not specified 77 days 5 2.36 ml/min 0.48 1.07 isolated perfused heart method 0.0 0 K1, myocardial flow rate 68596 733
SS/JrSeac myocardial clearance rate controlled sodium content diet (0.3 %) (for 35 days) then controlled oxygen content Kreb's solution perfusate (for 0.2 hours) then 99mTc-sestamibi (37 MBq/l) (for 0.3 hours) then Kreb's solution perfusate (for 0.4 hours) Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. heart muscle physiology trait not specified 126 days 5 0.0 /min 0.0 0.0 isolated perfused heart method 0.0 0 K2, myocardial clearance rate 68601 733
BN/NHsdMcwi white blood cell count controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. leukocyte quantity female 92 days-94 days 13 0.02 x 1000 cells/ul 1306.0 4708.85 isolated cell counting method 0.0 0 69495 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93 days 11 serial mean 446.8 beats/min 9.7 32.17 vascular indwelling catheter method left femoral artery 10800.0 0 69520 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94 days 17 serial mean 91.6 mmHg 3.6 14.84 vascular indwelling catheter method left femoral artery 10800.0 0 69523 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 94 days 10 serial mean 411.7 beats/min 10.6 33.52 vascular indwelling catheter method left femoral artery 10800.0 0 69526 151
LEW/Crlc cerebrospinal fluid chloride level controlled sodium content diet (8 %) (between 8 and 10 days) Huang BS, et al., Hypertension. 2007 Apr 9;. cerebrospinal fluid mineral amount male 43 days-52 days 0 121.0 mmol/l 1.0 chloride ion-selective electrode method 0.0 0 69694 344
SS/JrHsd diastolic blood pressure controlled sodium content diet (8 %) (between 55 and 56 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait male 139 days-140 days 6 162.7 mmHg 7.88 19.3 intra-aortic abdominal radiotelemetry 0.0 0 67869 810
SR/JrHsd diastolic blood pressure controlled sodium content diet (8 %) (between 55 and 56 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait male 139 days-140 days 5 93.4 mmHg 1.61 3.6 intra-aortic abdominal radiotelemetry 0.0 0 67870 810
SS/JrHsd diastolic blood pressure controlled sodium content diet (8 %) (between 83 and 84 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait female 167 days-168 days 8 143.0 mmHg 4.88 13.8 intra-aortic abdominal radiotelemetry 0.0 0 67871 810
SHRSP/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 31 151.0 mmHg 1.44 8.0 tail cuff plethysmography 0.0 0 69162 1126
SHRSP/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 26 187.0 mmHg 2.55 13.0 tail cuff plethysmography 0.0 0 69163 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 33 148.0 mmHg 3.13 18.0 tail cuff plethysmography 0.0 0 69166 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 33 174.0 mmHg 3.31 19.0 tail cuff plethysmography 0.0 0 69167 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 112 days 29 202.0 mmHg 1.67 9.0 tail cuff plethysmography 0.0 0 69170 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 126 days 31 208.0 mmHg 1.44 8.0 tail cuff plethysmography 0.0 0 69178 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 31 191.0 mmHg 0.72 4.0 tail cuff plethysmography 0.0 0 69182 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 30 195.0 mmHg 1.46 8.0 tail cuff plethysmography 0.0 0 69183 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 14 192.0 mmHg 1.6 6.0 tail cuff plethysmography 0.0 0 69199 1126
SS/JrHsdMcwi thymus wet weight controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. thymus mass not specified 84 days 0 560.0 mg 30.0 post excision weight measurement 0.0 0 69204 1057
WKY.SHR-(D1Mgh14-D1Rat77)/Iwai diastolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to ambient light (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 8 90.6 mmHg 1.27 3.6 vascular indwelling catheter method left common carotid artery 0.0 0 daytime (7 AM - 7 PM) 70095 1281
SS.LEW-(D17Chm131-D17Chm93)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 12 147.0 mmHg 8.0 27.71 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70495 1438
SS.SR-(D2Rat352-rs63922710)/Opaz pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 6 51.8 mmHg 2.3 5.63 intra-aortic abdominal radiotelemetry 0.0 0 70565 1458
SS.MNS-(D2Chm90-D2Rat38)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 144.0 mmHg 4.0 11.31 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70455 1438
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-91 days 20 serial mean 130.0 mmHg 3.5 15.65 vascular indwelling catheter method left femoral artery 0.0 0 69443 151
BN/NHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 89 days-92 days 25 35.0 ml/d 2.0 10.0 urine volume measurement method 0.0 0 69451 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89 days-91 days 18 serial mean 386.0 beats/min 4.1 17.39 vascular indwelling catheter method left femoral artery 0.0 0 69449 151
SS/JrHsdMcwi urine total protein level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (0.4 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. total urine protein amount female 90 days-94 days 18 2.63 mg/ml 0.47 1.99 urine total protein analysis 0.0 0 mg/ml 69458 151
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 89 days-92 days 24 0.96 mEq/d 0.04 0.21 unspecified method 0.0 0 urine potassium analysis 69461 151
SS/Jr heart left ventricle end-diastolic area controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart left ventricle size trait not specified 0 days 6 0.62 cm2 0.11 0.27 echocardiography 0.0 0 69596 749
WKY.SHR-(D1Mgh14-D1Rat77)/Iwai diastolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 8 96.8 mmHg 0.88 2.5 vascular indwelling catheter method left common carotid artery 0.0 0 nighttime (7 PM - 7 AM) 70096 1281
SS.SR-(D2Rat352-rs63922710)/Opaz mean arterial blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 6 142.0 mmHg 2.1 5.14 intra-aortic abdominal radiotelemetry 0.0 0 70559 1458
SS.SR-(D2Rat352-rs63922710)/Opaz diastolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 6 118.5 mmHg 2.2 5.39 intra-aortic abdominal radiotelemetry 0.0 0 70560 1458
SS.SR-(D2Rat352-rs63922710)/Opaz mean arterial blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 6 153.7 mmHg 3.1 7.59 intra-aortic abdominal radiotelemetry 0.0 0 70564 1458
SS/JrTol systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Pillai R, et al., Physiol Genomics. 2013 Aug 15;45(16):729-36. doi: 10.1152/physiolgenomics.00077.2013. Epub 2013 Jun 11. arterial blood pressure trait male 62 days-66 days 0 196.0 mmHg 6.8 tail cuff plethysmography 0.0 0 restrained, 28 degrees C 70583 1482
SS.LEW-(D10Rat119-D10Rat133)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 6 183.0 mmHg 9.0 22.05 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84479 1438
SS-Chr 12BN.SS-(D12Arb13-D12Mit2)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 67 days-77 days 8 serial mean 114.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96864 1718
SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 67 days-77 days 11 serial mean 146.0 mmHg 6.0 19.9 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96868 1718
SS.LEW-(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 109.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84485 1438
SS.LEW-(D3Rat2-D3Chm79)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 133.0 mmHg 5.0 11.18 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84493 1438
SS.LEW-(D7Uia3-D7Mgh1)(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 125.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84503 1438
SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 31 39.0 mg/d 4.31 24.0 Bradford protein assay 0.0 0 84578 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 126 days 1 400.0 mg/d Bradford protein assay 0.0 0 84587 1126
SS.MNS-(D2Rat155-D2Chm161)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 12 days) Chauvet C, et al., Hypertens Res. 2009 Jul;32(7):631-7. doi: 10.1038/hr.2009.70. Epub 2009 May 22. arterial blood pressure trait male 68 days 9 serial mean 125.0 mmHg 6.0 18.0 radiotelemetry 1036800.0 0 telemetry probe averaged over 12 days has records that will be duplicated if entered need to add multiple refs once the functionality is in 96575 1664
SS.MNS-(D2Chm366-D2Rat52)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 12 days) Chauvet C, et al., Hypertens Res. 2009 Jul;32(7):631-7. doi: 10.1038/hr.2009.70. Epub 2009 May 22. arterial blood pressure trait male 68 days 9 serial mean 139.0 mmHg 4.0 12.0 radiotelemetry 1036800.0 0 telemetry probe averaged over 12 days has records that will be duplicated if entered need to add multiple refs once the functionality is in 96578 1664
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (140 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63 days-70 days 7 7.8 % 0.4 1.06 unspecified method 0.0 0 mesenteric artery morphology trait 96879 1719
SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (40 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63 days-70 days 5 15.6 % 0.5 1.12 unspecified method 0.0 0 mesenteric artery morphology trait 96882 1719
SS-Chr 12BN/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (120 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63 days-70 days 7 8.7 % 0.4 1.06 unspecified method 0.0 0 mesenteric artery morphology trait 96878 1719
SS.BN-(D12Hmgc3-AU047911)/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (80 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63 days-70 days 12 9.5 % 0.4 1.39 unspecified method 0.0 0 mesenteric artery morphology trait 96892 1719
SS.BN-(D12Hmgc3-AU047911)/Mcwi artery wall thickness to artery inner diameter ratio controlled sodium content diet (0.3 %) then controlled ex vivo artery perfusion pressure (100 mmHg) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. mesenteric artery morphology trait male 63 days-70 days 12 8.6 % 0.3 1.04 unspecified method 0.0 0 mesenteric artery morphology trait 96893 1719
SS.MNS-(D2Chm25-D2Mit14)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 12 days) Chauvet C, et al., Hypertens Res. 2009 Jul;32(7):631-7. doi: 10.1038/hr.2009.70. Epub 2009 May 22. arterial blood pressure trait male 68 days 7 serial mean 136.0 mmHg 6.0 15.87 radiotelemetry 1036800.0 0 telemetry probe averaged over 12 days has records that will be duplicated if entered need to add multiple refs once the functionality is in 96574 1664
SS.LEW-(D10Chm280-D10Chm216)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 105 days) Crespo K, et al., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e. arterial blood pressure trait male 66 days-86 days 12 serial mean 149.0 mmHg 1.15 4.0 intra-aortic abdominal radiotelemetry 2.0 0 for 2 wks has records that will be duplicated if entered need to add multiple refs once the functionality is in 96579 1665
SS.BN-(D12Hmgc7-D12Hmgc6)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) then controlled sodium content diet (8 %) (for 21 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 92 days-98 days 6 150.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0.0 0 96807 1698
SHR-Ndufc2em1Mcwi+/+ body weight controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 126 days 10 309.0 g 8.54 27.0 body weighing method 0.0 0 97879 1938
LEW.SS-(D17Rat15-D17Rat51)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 41 days) Crespo K, et al., Circ Cardiovasc Genet. 2015 Aug;8(4):610-7. doi: 10.1161/CIRCGENETICS.114.000965. Epub 2015 May 11. arterial blood pressure trait male 67 days-77 days 5 89.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 864000.0 0 97143 1878
SHR-Ndufc2em1Mcwi-/+ body weight controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 126 days 17 308.0 g 5.09 21.0 body weighing method 0.0 0 97897 1938
SHR-Ndufc2em2Mcwi-/+ body weight controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 70 days 26 237.0 g 5.3 27.0 body weighing method 0.0 0 97903 1938
SHR-Ndufc2em2Mcwi+/+ body weight controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 126 days 12 314.0 g 14.15 49.0 body weighing method 0.0 0 97902 1938
SHR/Bbb body weight controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. body mass not specified 70 days 18 220.0 g 3.06 13.0 body weighing method 0.0 0 97906 1938
SS/JrTol systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 26 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 64 days-66 days 30 continuous mean 198.0 mmHg 8.0 43.82 tail cuff plethysmography 0.0 0 restrained, 28 degrees C average of 2-3 readings/day over 4 days 96920 1778
SS/JrTol heart rate controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Personal communication between Dr. Bina Joe's group and the RGD curators heart pumping trait male 73 days-75 days 10 serial mean 376.0 beats/min 15.0 47.43 radiotelemetry 345600.0 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 4-hour interval averages over 4 days 97022 1798
SS.LEW-(D1Mco134-D1Wox6)/Bj systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 64 days-66 days 30 continuous mean 155.0 mmHg 16.0 87.64 tail cuff plethysmography 0.0 0 restrained, 28 degrees C average of 2-3 readings/day over 4 days 96945 1778
SS/JrTol diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 73 days-75 days 10 serial mean 131.0 mmHg 5.0 15.81 radiotelemetry 345600.0 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 4-hour interval averages over 4 days 96949 1778
SS/JrTol mean arterial blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 73 days-75 days 10 159.0 mmHg 7.0 22.14 radiotelemetry 345600.0 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 24 hour 96957 1778
SS.LEW-(D1Rat200-D1Mco136)/Bj mean arterial blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 73 days-75 days 10 174.0 mmHg 5.0 15.81 radiotelemetry 345600.0 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 24 hour 96958 1778
SS/JrTol pulse pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 73 days-75 days 10 58.0 mmHg 4.0 12.65 radiotelemetry 345600.0 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 24 hour 96961 1778
SS/JrTol systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 26 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 64 days-66 days 30 continuous mean 208.0 mmHg 6.0 32.86 tail cuff plethysmography 0.0 0 restrained, 28 degrees C average of 2-3 readings/day over 4 days 96982 1778
SHR-Ndufc2em2Mcwi+/+ systolic blood pressure controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 70 days 12 undefined 181.0 mmHg 0.87 3.0 tail cuff plethysmography 0.0 0 97922 1938
SHR-Ndufc2em2Mcwi-/+ systolic blood pressure controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. arterial blood pressure trait not specified 126 days 16 undefined 186.0 mmHg 1.5 6.0 tail cuff plethysmography 0.0 0 97927 1938
SHRSP/Bbb urine total protein excretion rate controlled protein content diet (19.7 %) (for 49 days) and controlled potassium content diet (6.3 mg/g) (for 49 days) and controlled sodium content diet (3.7 mg/g) (for 49 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 91 days 5 240.0 mg/d 13.42 30.0 urine analysis 0.0 0 97932 1938
SHR-Ndufc2em1Mcwi+/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 126 days 10 67.0 mg/d 1.9 6.0 urine analysis 0.0 0 97935 1938
SHR-Ndufc2em2Mcwi-/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) and controlled sodium content diet (3.7 mg/g) (for 84 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 126 days 16 126.0 mg/d 6.75 27.0 urine analysis 0.0 0 97944 1938
SR/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 7.6 pg/ml 0.7 1.71 radioimmunoassay 0.0 ovx 63 days 102362 2686
SS/NEisSlc ratio of change in renal sympathetic nerve activity controlled sodium content diet (8 %) (for 28 days) then tempol (4 mol/l) (between 0 and 0 hours) Fujita M, et al., Hypertension. 2007 Aug;50(2):360-7. Epub 2007 Jun 18. kidney sympathetic nerve activity male 63 days-70 days 8 -18.7 % 2.0 5.66 implanted wire electrode recording method 0.0 0 102373 2687
SS/NEisSlc percent change in heart rate controlled sodium content diet (8 %) (for 28 days) then tempol (4 mol/l) (between 0 and 0 hours) Fujita M, et al., Hypertension. 2007 Aug;50(2):360-7. Epub 2007 Jun 18. heart pumping trait male 63 days-70 days 8 -10.7 % 2.8 7.92 vascular fluid filled catheter 0.0 0 102381 2687
SR/NEisSlc both kidneys wet weight to body weight ratio controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. kidney mass male 126 days 8 3.53 g/kg 0.04 0.11 post excision weight measurement 0.0 0 102322 2684
SS/NEisSlc both kidneys wet weight to body weight ratio controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. kidney mass male 126 days 8 5.19 g/kg 0.19 0.54 post excision weight measurement 0.0 0 102323 2684
SR/NEisSlc creatinine clearance controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. glomerular filtration trait male 126 days 8 3.9 ml/min 0.8 2.26 serum creatinine analysis 0.0 0 102331 2684
SS/NEisSlc creatinine clearance controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then tolvaptan (0.05 %) (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. glomerular filtration trait male 126 days 8 3.6 ml/min 0.7 1.98 serum creatinine analysis 0.0 0 102333 2684
SS/NEisSlc timed urine volume controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then tolvaptan (0.05 %) (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. urine output male 126 days 8 83.3 ml/d 7.9 22.34 urine volume measurement method 0.0 0 102336 2684
SS/NEisSlc urine total protein excretion rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. total urine protein amount male 126 days 8 307.0 mg/d 46.0 130.11 urine protein analysis 0.0 0 102338 2684
SS/NEisSlc urine total protein excretion rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then tolvaptan (0.05 %) (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. total urine protein amount male 126 days 8 124.0 mg/d 21.0 59.4 urine protein analysis 0.0 0 102339 2684
SS/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.4 hours) then ambient air (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 122.0 breaths/min 1.79 4.0 spirometry 0.0 0 103179 2787
SS/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.4 hours) then ambient air (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 4 sampling once per minute 96.0 breaths/min 4.0 8.0 spirometry 0.0 0 103212 2787
SS heart rate controlled sodium content diet (0.3 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. heart pumping trait male 42 days 5 438.0 beats/min 5.37 12.0 tail cuff plethysmography 0.0 0 103278 2803
SR/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.4 hours) then ambient air (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 89.0 breaths/min 6.26 14.0 spirometry 0.0 0 103213 2787
SS systolic blood pressure controlled sodium content diet (0.3 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. arterial blood pressure trait male 42 days 5 113.0 mmHg 2.24 5.0 tail cuff plethysmography 0.0 0 103284 2803
SS-Mthfrem1Mcwi-/+ heart wet weight controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. heart mass male 60 days-69 days 0 1.24 g 0.06 digital scale post excision weight measurement 0.0 0 98462 2059
SS-Plod1em1Mcwi-/- body weight controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. body mass male 60 days-69 days 0 298.0 g 6.0 body weighing method 0.0 0 98465 2059
SS.BN-(D13Hmgc1048-D13Hmgc1045)/Mcwi diastolic blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 44 days-53 days 11 serial mean 86.0 mmHg 2.0 6.63 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-O 98488 2079
SS.BN-(D13Hmgc885-D13Hmgc664)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 44 days-53 days 10 serial mean 105.0 mmHg 2.0 6.32 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-R 98477 2079
SS.BN-(D13Hmgc1041-D13Hmgc664)/Mcwi systolic blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 44 days-53 days 13 serial mean 121.0 mmHg 1.0 3.61 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-Q 98483 2079
SS.BN-(D13Got42-D13Hmgc885)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 46 days-53 days 3 serial mean 106.0 mmHg 2.31 4.0 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry strain 26-F 98605 2098
SS.BN-(D13Got42-D13Got45)/Mcwi heart rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. heart pumping trait male 60 days-67 days 13 serial mean 399.0 beats/min 9.0 32.45 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry intra-carotid radiotelemetry 98612 2098
SS/NEisSlc serum total protein level controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. blood total protein amount male 91 days 6 5.42 g/dl 0.11 0.27 serum total protein analysis 0.0 0 100670 2519
SS-Agtrapem4Mcwi-/- heart rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. heart pumping trait male 58 days-67 days 0 serial mean 350.0 beats/min 6.0 intra-aortic abdominal radiotelemetry 32400.0 0 98423 2059
SS body weight controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. body mass male 84 days 7 287.0 g 9.45 25.0 body weighing method 0.0 0 103298 2803
SR heart weight to body weight ratio controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 84 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. heart mass male 126 days 6 2.68 g/kg 0.24 0.58 post excision weight measurement 0.0 0 103307 2803
SS heart weight to body weight ratio controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. heart mass male 84 days 7 4.16 g/kg 0.15 0.41 post excision weight measurement 0.0 0 103304 2803
SS heart left ventricle end-systolic diameter controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. heart left ventricle end-systolic diameter male 84 days 7 4.3 mm 0.11 0.3 transthoracic echocardiography 0.0 0 103312 2803
SS plasma glucose level controlled sodium content diet (0.3 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. blood glucose amount male 42 days 12 96.0 mg/dl 4.62 16.0 plasma glucose analysis 0.0 0 103320 2803
SS/Jr mean arterial blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 7 serial mean 174.0 mmHg 1.74 4.6 radiotelemetry 0.0 0 97989 1958
SS plasma free fatty acids level controlled sodium content diet (0.3 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. blood free fatty acid amount male 42 days 12 1.4 mmol/l 0.06 0.2 thin layer chromatography 0.0 0 103332 2803
SS plasma free fatty acids level controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 84 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. blood free fatty acid amount male 126 days 12 0.8 mmol/l 0.06 0.2 thin layer chromatography 0.0 0 103336 2803
SS plasma triglyceride level controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. blood triglyceride amount male 84 days 13 1.28 mmol/l 0.12 0.44 thin layer chromatography 0.0 0 103340 2803
SR body weight controlled sodium content diet (6 %) (between 56 and 70 days) Kamei K, et al., Circ J. 2007 Mar;71(3):390-6. body mass male 98 days-132 days 7 405.0 g 15.5 41.0 body weighing method 0.0 0 103346 2804
SS heart ventricle septal wall thickness controlled sodium content diet (6 %) (between 56 and 70 days) then pentobarbital (50 mg/kg) Kamei K, et al., Circ J. 2007 Mar;71(3):390-6. heart left ventricle wall thickness male 98 days-132 days 7 0.17 cm 0.02 0.05 transthoracic echocardiography 0.0 0 103367 2804
SR conduction velocity controlled sodium content diet (6 %) (between 35 and 49 days) then pentobarbital (50 mg/kg) Kamei K, et al., Circ J. 2007 Mar;71(3):390-6. heart electrical impulse conduction trait male 77 days-91 days 7 77.0 cm/min 1.89 5.0 electrocardiography 0.0 0 conduction velocity 103387 2804
SS conduction velocity controlled sodium content diet (6 %) (between 35 and 49 days) then pentobarbital (50 mg/kg) Kamei K, et al., Circ J. 2007 Mar;71(3):390-6. heart electrical impulse conduction trait male 77 days-91 days 7 56.0 cm/min 2.65 7.0 electrocardiography 0.0 0 conduction velocity 103390 2804
SR/Hsd plasma osmolality controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13. blood molecular composition trait male 91 days-119 days 6 299.6 umol/g 4.5 11.02 osmometry 0.0 0 p osmolality mosm/kg 102237 2682
SR/Hsd plasma osmolality controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days) Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13. blood molecular composition trait male 91 days-119 days 6 302.4 umol/g 4.2 10.29 osmometry 0.0 0 p osmolality mosm/kg 102238 2682
SR/Hsd plasma sodium level controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13. blood sodium amount male 91 days-119 days 6 140.8 mmol/l 1.6 3.92 flame atomic emission spectrometry 0.0 0 102249 2682
SR/Hsd plasma sodium level controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13. blood sodium amount male 91 days-119 days 6 139.8 mmol/l 0.7 1.71 flame atomic emission spectrometry 0.0 0 102251 2682
SR/Hsd plasma osmolality controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13. blood molecular composition trait male 91 days-119 days 6 298.6 umol/g 3.8 9.31 osmometry 0.0 0 p osmolality mosm/kg 102257 2682
SR/Hsd plasma osmolality controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days) then surgical denervation (for 21 days) Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13. blood molecular composition trait male 91 days-119 days 6 300.9 umol/g 3.7 9.06 osmometry 0.0 0 p osmolality mosm/kg 102260 2682
SS/Hsd plasma osmolality controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13. blood molecular composition trait male 91 days-119 days 6 301.4 umol/g 4.2 10.29 osmometry 0.0 0 p osmolality mosm/kg 102261 2682
SS.BN-(D13Hmgc1041-D13Hmgc664)/Mcwi heart rate controlled sodium content diet (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. heart pumping trait male 44 days-53 days 13 serial mean 413.0 beats/min 5.0 18.03 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-Q 98518 2079
SS-Nppbem2Mcwi+/+ heart left ventricle end-diastolic diameter controlled sodium content diet (for 21 days) Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 98 days 4 8.75 mm 0.66 1.32 echocardiography 0.0 0 99712 2319
SS.BN-(D13Rat151-D13Rat197)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. urine albumin amount male 60 days-67 days 14 147.0 mg/d 18.0 67.35 urine microalbumin analysis 0.0 0 98625 2098
SS.BN-(D13Hmgc5885-D13Rat32)/Mcwi heart rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. heart pumping trait male 60 days-67 days 14 serial mean 402.0 beats/min 9.0 33.67 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry intra-carotid radiotelemetry 98619 2098
SS.BN-(D13Got42-D13Rat130)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. urine albumin amount male 60 days-67 days 14 239.0 mg/d 29.0 108.51 urine microalbumin analysis 0.0 0 strain 26-C 98628 2098
SS.BN-(D13Got42-D13Hmgc497)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. urine albumin amount male 60 days-67 days 7 75.0 mg/d 18.0 47.62 urine microalbumin analysis 0.0 0 strain 26-E 98630 2098
SS.BN-(D13Hmgc5885-D13Rat32)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. urine albumin amount male 60 days-67 days 14 288.0 mg/d 28.0 104.77 urine microalbumin analysis 0.0 0 strain 26-I 98634 2098
SS.BN-(D13Got45-D13Hmgc664)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. urine albumin amount male 60 days-67 days 14 167.0 mg/d 28.0 104.77 urine microalbumin analysis 0.0 0 strain 26-M 98638 2098
LH/MavRrrcAek serum low density lipoprotein cholesterol level controlled sodium content diet (0.3 %) (for 105 days) then controlled sodium content diet (4 %) (for 21 days) Ma MCJ, et al., PLoS One. 2017 Aug 8;12(8):e0182650. doi: 10.1371/journal.pone.0182650. eCollection 2017. blood LDL cholesterol amount male 126 days 7 33.5 mg/dl 4.4 11.64 serum low-density lipoprotein-cholesterol measurement test 0.0 0 102784 2722
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Flister MJ, et al., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. urine albumin amount male 91 days 10 231.0 mg/d 30.0 94.87 urine microalbumin analysis 10800.0 0 98725 2142
SS.BN-(D13Hmgc64-4582)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Flister MJ, et al., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. urine albumin amount male 91 days 24 242.0 mg/d 23.0 112.68 urine microalbumin analysis 10800.0 0 Strain 9B 98728 2142
SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Flister MJ, et al., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. urine albumin amount male 91 days 10 243.0 mg/d 30.0 94.87 urine microalbumin analysis 10800.0 0 98726 2142
SR/JrHsd both kidneys wet weight controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. kidney mass female 112 days 6 1.57 g 0.04 0.1 post excision weight measurement 0.0 sham ovx 63 days 102349 2686
SS/JrHsd uterus weight controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. uterus mass female 112 days 6 0.44 g 0.01 0.02 post excision weight measurement 0.0 ovx 63 days 102354 2686
SS-Renem1Mcwi+/+ body weight controlled sodium content diet (0.4 %) (for 49 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. body mass female 70 days 8 204.5 g 3.31 9.36 body weighing method 0.0 0 98292 2038
SS-Renem1Mcwi-/- heart weight to body weight ratio controlled sodium content diet (0.4 %) (for 49 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. heart mass male 70 days 8 3.1 g/kg 0.1 0.28 digital scale post excision weight measurement 0.0 0 98297 2038
SS-Renem1Mcwi+/- heart weight to body weight ratio controlled sodium content diet (0.4 %) (for 49 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. heart mass male 70 days 9 3.6 g/kg 0.1 0.3 digital scale post excision weight measurement 0.0 0 98296 2038
SS.SHR-(D9Mco113-D9Mco124)/Bj bone section surface density controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 954.9 mg/cm3 12.9 micro-computed tomography 0.0 0 mg HA/ccm 98015 1958
SS-Agtrapem4Mcwi-/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 131.0 mmHg 3.0 intra-aortic abdominal radiotelemetry 32400.0 0 98402 2059
SS-Clcn6em2Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 123.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 32400.0 0 98400 2059
SS.BN-(D13Hmgc885-D13Hmgc664)/Mcwi diastolic blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 44 days-53 days 10 serial mean 86.0 mmHg 2.0 6.32 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-R 98491 2079
SS-Nppaem4Mcwi-/- diastolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 143.0 mmHg 5.0 intra-aortic abdominal radiotelemetry 32400.0 0 98406 2059
SS.BN-(D13Hmgc1041-D13Hmgc664)/Mcwi diastolic blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 58 days-67 days 13 serial mean 141.0 mmHg 4.0 14.42 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-Q 98511 2079
SS.BN-(D13Hmgc1041-D13Hmgc664)/Mcwi systolic blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 58 days-67 days 13 serial mean 185.0 mmHg 4.0 14.42 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-Q 98504 2079
SS.BN-(D13Got42-D13Rat130)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60 days-67 days 14 serial mean 160.0 mmHg 3.0 11.22 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry strain 26-C 98555 2098
SS.BN-(D13Hmgc86-D13Got22)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. arterial blood pressure trait male 89 days 16 serial mean 161.0 mmHg 4.0 16.0 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 0 strain 5-3 98676 2138
SS.BN-(D13Hmgc85-D13Got22)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. arterial blood pressure trait male 89 days 14 serial mean 184.0 mmHg 6.0 22.45 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 0 strain 5-6 98680 2138
SS.BN-(D13Rat111-D13Rat115)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. arterial blood pressure trait male 89 days 10 serial mean 179.0 mmHg 5.0 15.81 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 0 strain 5-8 98682 2138
SS.BN-(D13Hmgc86-D13Got22)/Mcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89 days 18 208.0 mg/d 20.0 84.85 Bradford protein assay 1.0 0 strain 5-3 98690 2138
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89 days 16 365.0 mg/d 37.0 148.0 Bradford protein assay 1.0 0 98685 2138
SS-Chr 13BN/Mcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89 days 9 162.0 mg/d 24.0 72.0 Bradford protein assay 1.0 0 98686 2138
SS.BN-(D13Rat111-D13Got22)/Mcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89 days 12 304.0 mg/d 53.0 183.6 Bradford protein assay 1.0 0 98687 2138
SS.BN-(D13Hmgc40-D13Got22)/Mcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89 days 16 380.0 mg/d 41.0 164.0 Bradford protein assay 1.0 0 strain 5-5 98693 2138
SS.BN-(D13Rat77-D13Got22)/Mcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89 days 16 519.0 mg/d 69.0 276.0 Bradford protein assay 1.0 0 strain 5-7 98695 2138
SS.BN-(D13Rat25-RN34_13048990782)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. arterial blood pressure trait male 91 days 21 serial mean 169.0 mmHg 6.0 27.5 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 0 strain 9C 98703 2141
SS.BN-(D13Rat25-rs198199323)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. urine albumin amount male 91 days 12 224.0 mg/d 31.0 107.39 urine microalbumin analysis 1.0 0 strain 9F 98717 2141
SS/Jr heart rate controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. heart pumping trait male 68 days-70 days 6 serial mean 394.0 beats/min 5.97 14.62 radiotelemetry 0.0 0 98193 1958
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 58 days-67 days 14 serial mean 163.0 mmHg 4.0 14.97 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant 98493 2079
SS/NEisSlc systolic blood pressure controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then tolvaptan (0.05 %) (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. arterial blood pressure trait male 126 days 8 undefined 235.0 mmHg 13.0 36.77 tail cuff plethysmography 0.0 0 102315 2684
SS/NEisSlc heart left ventricle fractional shortening controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. heart left ventricle end-diastolic diameter male 126 days 8 24.8 % 1.2 3.39 transthoracic echocardiography 0.0 0 102317 2684
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 20 and 29 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. urine albumin amount male 41 days-50 days 14 2.8 mg/d 0.5 1.87 urine microalbumin analysis 86400.0 0 98528 2079
SS.BN-(D13Hmgc1048-D13Hmgc664)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 20 and 29 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. urine albumin amount male 41 days-50 days 15 1.7 mg/d 0.4 1.55 urine microalbumin analysis 86400.0 0 strain 26-N 98529 2079
SS.BN-(D13Hmgc1048-D13Hmgc1045)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 20 and 29 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. urine albumin amount male 41 days-50 days 11 1.2 mg/d 0.3 0.99 urine microalbumin analysis 86400.0 0 strain 26-N 98530 2079
SS.BN-(D13Hmgc1048-D13Hmgc1050)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 20 and 29 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. urine albumin amount male 41 days-50 days 11 2.2 mg/d 0.3 0.99 urine microalbumin analysis 86400.0 0 strain 26-P 98531 2079
SS-Renem1Mcwi+/+ serum alanine aminotransferase activity level controlled sodium content diet (0.4 %) (for 42 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. blood alanine transaminase amount male 63 days 5 33.4 U/l 1.93 4.32 automated serum analysis 0.0 0 98355 2038
SS-Renem1Mcwi+/+ serum chloride level controlled sodium content diet (0.4 %) (for 42 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. blood chloride amount female 63 days 8 96.88 mmol/l 0.56 1.58 automated serum electrolyte analysis 0.0 0 98364 2038
SS.BN-(D13Hmgc5885-D13Rat32)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60 days-67 days 14 serial mean 170.0 mmHg 5.0 18.71 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry strain 26-I 98561 2098
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic posterior wall thickness controlled sodium content diet (for 21 days) Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 98 days 4 1.87 mm 0.2 0.4 echocardiography 0.0 0 99715 2319
SS.SHR-(D9Mco113-D9Mco124)/Bj bone section mineralized tissue volume controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 2.04 mm3 0.14 micro-computed tomography 0.0 0 bone volume 98020 1958
SS/JrIpcv plasma triglyceride level controlled sodium content diet (0.3 %) Hojn¿ S, et al., Physiol Res. 2005;54(2):201-6. blood triglyceride amount male 0 days 0 1.2 mmol/l 0.16 plasma triglyceride analysis 0.0 0 102402 2688
SS-Clcn6em2Mcwi single kidney wet weight controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. kidney mass male 60 days-69 days 0 1.53 g 0.04 digital scale post excision weight measurement 0.0 0 98454 2059
SS/Hsd single kidney wet weight controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. kidney mass male 60 days-69 days 0 1.46 g 0.02 digital scale post excision weight measurement 0.0 0 98457 2059
SS.BN-(D13Hmgc885-D13Hmgc664)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. urine albumin amount male 59 days-68 days 10 240.0 mg/d 35.0 110.68 urine microalbumin analysis 86400.0 0 strain 26-R 98540 2079
SS/Hsd urine creatinine excretion rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. urine creatinine amount male 60 days-69 days 0 11.5 mg/d 0.4 urine creatinine analysis 0.0 0 98443 2059
WKY/NHsd skin chloride level to skin dry weight ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 0.07 mmol/g 0.01 0.02 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl mmol/g 99137 2238
SS-Nppaem4Mcwi-/- urine total protein excretion rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. total urine protein amount male 60 days-69 days 0 73.0 mg/d 8.0 urine total protein analysis 0.0 0 98432 2059
SS.SHR-(D9Mco113-D9Mco124)/Bj systolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 6 serial mean 164.0 mmHg 5.22 12.79 radiotelemetry 0.0 0 97953 1958
SS/NEisSlc serum chloride level controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. blood chloride amount male 91 days 12 101.1 mmol/l 1.61 5.58 automated serum chloride test 0.0 0 100662 2519
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60 days-67 days 12 serial mean 204.0 mmHg 4.0 13.86 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry 98566 2098
SR/NEisSlc serum sodium level controlled sodium content diet (0.3 %) (for 91 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. blood sodium amount male 91 days 6 138.0 mmol/l 5.76 14.11 automated serum sodium test 0.0 0 100653 2519
SS/NEisSlc urine aldosterone excretion rate controlled sodium content diet (8 %) (for 49 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. urine aldosterone amount male 49 days 30 13.84 ng/d 1.27 6.96 radioimmunoassay 0.0 0 ng/d 100692 2519
SS/NEisSlc kidney weight controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. kidney mass male 91 days 12 1.83 g 0.03 0.11 post excision weight measurement 0.0 0 100701 2519
SS/NEisSlc heart weight controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. heart mass male 91 days 6 1.49 g 0.05 0.12 post excision weight measurement 0.0 0 100710 2519
SS/NEisSlc single kidney wet weight to body weight ratio controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. kidney mass male 91 days 6 5.39 g/kg 0.15 0.37 post excision weight measurement 0.0 0 100715 2519
SD-Nfe2l2em1Mcwi-/- body weight controlled sodium content diet (0.4 %) (between 70 and 84 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. body mass male 56 days-70 days 4 287.0 g 26.7 53.4 body weighing method 0.0 0 100732 2520
SS-Renem1Mcwi+/+ timed urine volume controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. urine output male 56 days 5 7.72 ml/d 1.55 3.47 metabolic cage urine volume measurement method 0.0 0 98313 2038
SS-Renem1Mcwi+/- urine total protein excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. total urine protein amount male 56 days 9 85.47 mg/d 10.93 32.79 urine total protein analysis 0.0 0 98320 2038
SS-Renem1Mcwi-/- urine total protein excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. total urine protein amount female 56 days 4 12.75 mg/d 8.08 16.16 urine total protein analysis 0.0 0 98324 2038
SS-Renem1Mcwi+/+ urine sodium excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. urine sodium amount male 56 days 5 0.65 mEq/d 0.25 0.56 urine sodium analysis 0.0 0 98325 2038
SS-Renem1Mcwi-/- urine sodium excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. urine sodium amount female 56 days 4 0.34 mEq/d 0.14 0.28 urine sodium analysis 0.0 0 98330 2038
SS-Renem1Mcwi+/- serum creatinine level controlled sodium content diet (0.4 %) (for 42 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. blood creatinine amount male 63 days 9 0.26 mg/dl 0.02 0.06 serum creatinine analysis 0.0 0 98344 2038
SS-Renem1Mcwi+/- serum urea nitrogen level controlled sodium content diet (0.4 %) (for 42 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. blood urea nitrogen amount female 63 days 4 108.0 mg/dl 3.24 6.48 serum urea nitrogen analysis 0.0 0 98342 2038
SS-Renem1Mcwi+/+ creatinine clearance to total kidney weight ratio controlled sodium content diet (0.4 %) (for 42 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. glomerular filtration trait male 63 days 5 0.9 ml/min/g 0.1 0.22 unspecified method 0.0 0 98349 2038
SS-Renem1Mcwi+/- creatinine clearance to total kidney weight ratio controlled sodium content diet (0.4 %) (for 42 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. glomerular filtration trait female 63 days 9 0.79 ml/min/g 0.07 0.21 unspecified method 0.0 0 98353 2038
WKY/NHsd creatinine clearance controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. glomerular filtration trait male 0 days 8 3.5 ml/min 0.2 0.57 urine creatinine analysis 0.0 0 99182 2238
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 8 serial mean 152.0 mmHg 6.49 18.36 radiotelemetry 0.0 0 97987 1958
F344-Hsd11b2em1Jmul-/- food intake rate controlled sodium content diet (0.3 %) Mullins LJ, et al., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15. eating behavior trait male 161 days 5 15.82 g/d 0.43 0.96 food intake measuring method 0.0 0 104998 3008
F344-Hsd11b2em1Jmul+/+ food intake rate controlled sodium content diet (0.3 %) then controlled sodium content diet (0.03 %) (between 7 and 10 days) Mullins LJ, et al., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15. eating behavior trait male 168 days 5 13.6 g/d 0.3 0.67 food intake measuring method 0.0 0 105001 3008
F344-Hsd11b2em1Jmul-/- timed urine volume controlled sodium content diet (0.3 %) then controlled sodium content diet (0.03 %) (between 7 and 10 days) Mullins LJ, et al., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15. urine output male 168 days 5 3.8 ml/d 0.3 0.67 urine volume measurement method 0.0 0 105014 3008
F344-Hsd11b2em1Jmul-/- urine sodium level controlled sodium content diet (0.3 %) Mullins LJ, et al., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15. urine sodium amount male 161 days 5 1075.1 mmol/l 45.6 101.96 urine sodium analysis 0.0 0 105022 3008
F344-Hsd11b2em1Jmul+/+ urine sodium level controlled sodium content diet (0.3 %) Mullins LJ, et al., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15. urine sodium amount male 161 days 4 817.2 mmol/l 39.6 79.2 urine sodium analysis 0.0 0 105021 3008
F344-Hsd11b2em1Jmul-/- urine sodium level to urine potassium level ratio controlled sodium content diet (0.3 %) Mullins LJ, et al., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15. urine sodium amount male 161 days 5 0.53 null 0.01 0.02 urine electrolyte analysis 0.0 0 105034 3008
F344-Hsd11b2em1Jmul-/- urine sodium level to urine potassium level ratio controlled sodium content diet (0.3 %) then controlled sodium content diet (3 %) (between 7 and 10 days) Mullins LJ, et al., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15. urine sodium amount male 168 days 5 7.54 null 0.39 0.87 urine electrolyte analysis 0.0 0 105036 3008
SS-Plekha7em4Mcwi-/- urine sodium level controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. urine sodium amount male 91 days 10 306.0 mmol/l 30.0 94.87 urine sodium analysis 0.0 0 105783 3022
SS-Plekha7em4Mcwi+/+ urine potassium level controlled sodium content diet (8 %) (for 7 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. urine potassium amount male 70 days 10 19.8 mmol/l 1.7 5.38 urine potassium analysis 0.0 0 105786 3022
SS-Plekha7em4Mcwi+/+ both kidneys wet weight as percentage of body weight controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. kidney mass male 91 days 10 4.31 % 0.1 0.32 post excision weight measurement 0.0 0 105744 3022
SS-Plekha7em4Mcwi+/+ renal medulla volume controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. kidney medulla morphology trait male 91 days 10 450.0 mm3 33.0 104.36 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 105746 3022
SS-Plekha7em4Mcwi-/- renal medulla volume controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. kidney medulla morphology trait male 91 days 10 497.0 mm3 14.0 44.27 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 105747 3022
SS-Plekha7em4Mcwi-/- heart weight controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. heart mass male 91 days 10 1.71 g 0.04 0.13 post excision weight measurement 0.0 0 105755 3022
SS-Plekha7em4Mcwi-/- timed urine volume controlled sodium content diet (8 %) (for 21 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. urine output male 84 days 10 71.34 ml/d 2.26 7.15 urine volume measurement method 0.0 0 105771 3022
SS-Plekha7em4Mcwi+/+ urine potassium level controlled sodium content diet (8 %) (for 14 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. urine potassium amount male 77 days 10 20.9 mmol/l 1.5 4.74 urine potassium analysis 0.0 0 105788 3022
SS-Plekha7em4Mcwi+/+ body weight controlled sodium content diet (0.4 %) (for 42 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. body mass male 63 days 10 250.0 g 8.0 25.3 body weighing method 0.0 0 105736 3022
SS-Plekha7em4Mcwi+/+ body weight controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. body mass male 91 days 10 371.0 g 5.0 15.81 body weighing method 0.0 0 105742 3022
SS-Plekha7em4Mcwi+/+ urine albumin excretion rate controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. urine albumin amount male 91 days 10 211.0 mg/d 22.0 69.57 urine albumin analysis 0.0 0 105738 3022
SHRSP/A3NCrl brain infarction volume controlled protein content diet (16 %) (for 63 days) and controlled sodium content diet (4 %) (for 63 days) and controlled potassium content diet (0.75 %) (for 63 days) and unilateral carotid artery occlusion (for 63 days) then dimethyl sulfoxide (30 %) (for 63 days) and Kolliphor HS 15 (25 %) (for 0 hours) Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24. brain integrity trait male 147 days 8 53.0 mm3 7.4 20.93 magnetic resonance imaging corpus callosum 0.0 0 corpus callosum-right hemisphere corpus callosum-right hemisphere 107287 3079
SHRSP/A3NCrl partial pressure of brain white matter oxygen right carotid artery occlusion then controlled protein content diet (16 %) (for 7 days) and controlled sodium content diet (4 %) (for 7 days) and controlled potassium content diet (0.75 %) (for 7 days) and controlled sodium chloride content drinking water (1 %) (for 7 days) Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 91 days 17 19.5 mmHg 1.2 4.95 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds 107325 3080
SHRSP/A3NCrl partial pressure of brain white matter oxygen right carotid artery occlusion then controlled protein content diet (16 %) (for 14 days) and controlled sodium content diet (4 %) (for 14 days) and controlled potassium content diet (0.75 %) (for 14 days) and controlled sodium chloride content drinking water (1 %) (for 14 days) Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 98 days 17 15.1 mmHg 1.2 4.95 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds 107326 3080
SS-Chr 7BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 11 14.58 mEq/d 1.41 4.68 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52745 482
SS-Chr 13BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 20 8.83 mEq/d 0.82 3.65 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52753 482
SS-Chr 12BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 8 19.17 mEq/d 2.94 8.3 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52775 482
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 0.3 ng/ml/h 0.03 0.07 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50535 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 5 1.57 ng/ml/h 0.07 0.16 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50538 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 118.22 mmHg 2.65 7.94 vascular fluid filled catheter 0 50546 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -11.11 beats/min 8.75 26.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50618 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 0.28 beats/min 13.27 39.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50624 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 10 -17.53 mmHg 2.45 7.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50632 481
GH/OmrMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 161.63 mmHg 6.61 14.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50643 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 124.75 mmHg 1.05 3.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50649 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 46.25 mmHg 3.11 7.61 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50660 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 13 17.49 beats/min 12.18 43.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50680 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 6.32 mmHg 3.54 7.91 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50702 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -21.2 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50682 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 34.55 beats/min 25.93 51.86 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50688 481
SS-Chr 9BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 15 131.76 mmHg 1.99 7.71 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50741 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 2.03 mmHg 7.31 14.61 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50811 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 8.29 beats/min 21.22 47.46 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50905 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 15 10.04 mmHg 1.85 7.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50913 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 12 6.66 mmHg 2.3 7.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50918 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 122.29 mmHg 2.81 6.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50938 481
SS-Chr 9BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 128.48 mmHg 4.68 11.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50946 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 13.28 mmHg 2.14 8.01 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50958 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 1.22 mmHg 1.8 6.74 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51039 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 -15.09 beats/min 14.75 39.03 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51036 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -15.33 beats/min 20.43 50.04 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51071 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 0.91 mmHg 0.96 2.14 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51082 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 -11.72 beats/min 10.1 17.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51090 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 8.62 mmHg 1.62 4.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51107 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -18.16 beats/min 10.99 29.07 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51215 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -1.39 beats/min 7.41 20.95 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51240 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 1 432.84 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51254 481
GH/OmrMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 10 415.95 beats/min 4.14 13.08 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51282 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51315 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 108.6 mmHg 0.71 1.58 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51326 481
SS.SHR-(D9Mco72-D9Uia4)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 181.0 mmHg 3.91 tail cuff plethysmography 0.0 0 67516 749
SS.SHR-(D9Rat7-D9Got111)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. body mass not specified 0 days 0 347.0 g 4.08 body weighing method 0.0 0 67539 749
SS.SHR-(D9Mco72-D9Mco106)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. body mass not specified 0 days 0 300.0 g 4.41 body weighing method 0.0 0 67536 749
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 1.68 g 0.06 post excision weight measurement 0.0 0 67552 749
SS.SHR-(D9Rat7-D9Rat84)/Mco heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 1.38 g 0.02 post excision weight measurement 0.0 0 67557 749
SS.SHR-(D9Rat7-D9Mco91)/Mco heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 1.52 g 0.01 post excision weight measurement 0.0 0 67560 749
SS.SHR-(D9Mco72-D9Mco109)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.01 g/kg 0.03 post excision weight measurement 0.0 0 67565 749
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.19 g/kg 0.08 post excision weight measurement 0.0 0 67562 749
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.24 g/kg 0.1 post excision weight measurement 0.0 0 67575 749
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 102.0 mg/d 6.81 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67588 749
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 3 -20.8 beats/min 34.71 60.12 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51405 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 2.02 mmHg 2.22 5.88 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51418 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 38.71 mmHg 5.37 13.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51424 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 17 30.86 mmHg 2.26 9.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51421 481
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 20 132.7 mg/d 21.27 95.13 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51435 481
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 11 41.53 mg/d 8.23 27.31 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51441 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.08 mEq/d 0.16 0.45 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51521 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 10 1.17 mEq/d 0.16 0.49 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51527 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.27 mg/dl 0.01 0.02 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51535 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.3 mg/dl 0.06 0.15 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51538 481
SS-Chr 16BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.27 ml/min 0.09 0.19 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51543 481
SS-Chr 16BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 6 19.21 mg/d 2.42 5.92 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51555 481
SS-Chr 16BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 8 24.09 mg/d 2.71 7.66 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51557 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 18 400.82 beats/min 9.27 39.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51577 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 129.04 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51630 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 -1.31 mmHg 3.14 9.41 vascular fluid filled catheter 0 51622 481
SS.LEW-(D8Rat56-D8Rat51)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 arterial blood pressure trait male 68 days-98 days 9 197.0 mmHg 6.0 18.0 radiotelemetry 30 0 11950 226
SS.LEW-(D16Rat12-D16Chm23)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 arterial blood pressure trait male 68 days-98 days 10 167.0 mmHg 8.0 25.3 radiotelemetry 30 0 11959 226
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96 days 24 continuous mean 141.0 mmHg 5.0 24.49 vascular indwelling catheter method femoral artery 10800.0 0 left femoral artery 12038 229
Crl:CD(SD) urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 9 13.41 mEq/d 1.64 4.91 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51639 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -33.0 beats/min 25.62 72.46 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50348 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 8.0 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50354 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -40.59 beats/min 39.51 88.34 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50345 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -34.84 beats/min 18.09 51.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50362 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 4.74 mmHg 3.69 9.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50376 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 3.34 ng/ml/h 0.14 0.39 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50393 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 7 15.17 ng/ml/h 1.06 2.81 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50414 481
SS.LEW-(D17Chm9-D17Rat97)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 10 10.3 g/kg 0.4 1.26 post excision weight measurement 0 0 64777 226
SS.LEW-(D16Rat38-D16Chm66)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 8 10.5 g/kg 0.4 1.13 post excision weight measurement 0 0 64782 226
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 7 1.67 ng/ml/h 0.24 0.62 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50463 481
WKY/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 9 0.76 mg/d 0.07 0.21 automated urine analysis 0 50466 481
SS.LEW-(D10Rat27-Igfbp4)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 7 10.9 g/kg 0.4 1.06 post excision weight measurement 0 0 64787 226
SS.MNS-(D2Rat183-D2Chm113)/Ayd both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 8 9.9 g/kg 0.2 0.57 post excision weight measurement 0 0 64798 226
SS.MNS-(D2Wox27-Adh1)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 5 3.1 mg/g 0.1 0.22 post excision weight measurement 0 0 64956 226
SS.LEW-(D10Chm128-D10Chm121)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 9 2.9 mg/g 0.2 0.6 post excision weight measurement 0 0 64918 226
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (for 24 days) Rapp JP, et al., Genomics 1998 Jul 15;51(2):191-6 arterial blood pressure trait male 62 days 20 195.0 mmHg 2.7 12.07 tail cuff plethysmography 0 0 only mentioned blood pressure 65829 633
SS.LEW-(D10Mco84-D10Mco134)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 3.95 g/kg 0.02 post excision weight measurement 0 12051 205
SS.LEW-(D2Rat18-D2Chm277)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 6 4.2 g/kg 0.1 0.24 post excision weight measurement 0 0 12089 226
SS.LEW-(D10Rat27-Igfbp4)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 7 3.6 g/kg 0.1 0.26 post excision weight measurement 0 0 12109 226
SS.LEW-(D17Chm14-D17Rat181)/Ayd heart weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart mass male 98 days 5 3.3 g/kg 0.1 0.22 post excision weight measurement 0 0 12117 226
SS.MNS-(D10Mco62-D10Got99)/Mco body weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 body mass male 64 days-68 days 20 304.0 g 2.1 9.39 body weighing method 0 0 12147 232
SS.SR-(D3Mco36-D3Got166)/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 40 303.9 g 2.0 12.65 body weighing method 0 12283 237
SR/JrHsd plasma total cholesterol level controlled sodium content diet (0.3 %) (for 180 days) then fasting (for 16 hours) Herrera VL, et al., J Hypertens. 2007 Aug;25(8):1608-12 blood cholesterol amount male 180 days 6 61.0 mg/dl 8.11 19.86 plasma total cholesterol measurement test 0 12291 238
SHR/NHsd body weight controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. body mass male 84 days 12 292.0 g 3.6 12.47 body weighing method 0.0 0 12334 246
SS/Jr body weight controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. body mass male 84 days 12 375.0 g 6.0 20.78 body weighing method 0.0 0 12331 246
SS.LEW-(D3Rat52-D3Chm57)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 23 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. arterial blood pressure trait male 56 days-60 days 5 135.0 mmHg 0.89 2.0 radiotelemetry 86400 0 two 24 hours widely separated periods, data represent averages of all readings over the 24-h measurements 65003 542
SS.BN-(D13Rat111-D13Rat127)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84 days-88 days 12 36.4 mg/d 6.7 23.21 urine analysis 86400 0 65215 15
SS.BN-(D13Rat91-D13Rat179)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 74.5 mg/d 7.5 25.98 urine analysis 86400 0 65226 15
SS.BN-(D13Rat127-D13Rat61)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 70.8 mg/d 12.2 42.26 urine analysis 86400 0 65229 15
SS.BN-(D13Rat127-D13Rat46)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 43.4 mg/d 6.4 22.17 urine analysis 86400 0 65237 15
SS.BN-(D13Rat183-D13Rat192)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 137.1 mg/d 27.8 96.3 urine analysis 86400 0 65245 15
SS.LEW-(D3Mco21-D3Rat17)/Ayd diastolic blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 42 days) Palijan A, et al., Physiol Genomics 2003 Sep 29;15(1):1-8. arterial blood pressure trait male 66 days-77 days 6 measurement taken every 4 hours during a 24-hour period serial mean 140.0 mmHg 8.0 19.6 radiotelemetry 86400.0 0 65558 615
SS.LEW-(D3Rat52-D3Rat130)/Ayd diastolic blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 42 days) Palijan A, et al., Physiol Genomics 2003 Sep 29;15(1):1-8. arterial blood pressure trait male 66 days-77 days 7 measurement taken every 4 hours during a 24-hour period serial mean 121.0 mmHg 4.0 10.58 radiotelemetry 86400.0 0 65556 615
SS.BN-(D13Rat111-D13Got22)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 159.0 mmHg 5.6 19.4 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 5398 15
SS.BN-(D13Rat7-D13Rat60)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 165.0 mmHg 6.6 22.86 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 5396 15
SS.LEW-(D18Chm41-D18Rat92)/Ayd heart left ventricle wet weight controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle mass male 77 days 8 0.92 g 0.02 0.05 post excision weight measurement 0 0 65030 542
SS.LEW-(D18Rat29-D18Rat55)/Ayd heart rate controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart pumping trait male 77 days 11 427.1 beats/min 3.59 11.9 transthoracic echocardiography 0 0 65014 542
SS.BN-(D13Rat20-D13Got22)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 192.0 mmHg 2.8 9.7 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 65164 15
SS-Tfdp2em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 150.33 mmHg 14.89 25.79 radiotelemetry carotid artery 0 - 66675 717
SS-Nckap5em3Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 140.33 mmHg 6.23 10.79 radiotelemetry carotid artery 0 - 66680 717
SS-Mas1em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 154.0 mmHg 17.0 24.04 radiotelemetry carotid artery 0 - 66685 717
SS-Ube2q2em3Mcwi-/- urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 2 12.16 mg/d 0.11 0.15 automated urine analysis 0 - 66749 717
SS-Acad10em2Mcwi+/+ urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70 days-77 days 5 11.26 mg/d 0.74 1.65 automated urine analysis 0 - 66747 717
SS-Mmp2em1Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 6 1.36 g 0.09 0.23 post excision weight measurement 0 - 66752 717
SS-Bcas3em4Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 3 1.26 g 0.06 0.11 post excision weight measurement 0 - 66765 717
SS-Apoeem7Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.36 g 0.08 0.18 post excision weight measurement 0 - 66779 717
SS-Rag1em2Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 1 1.36 g post excision weight measurement 0 - 66797 717
SS-Nckap5em3Mcwi-/- left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 3 1.58 g 0.1 0.17 post excision weight measurement 0 - 66803 717
SS.LEW-(D17Mco3-D17Mco10)/Jr body weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass not specified 64 days-71 days 20 287.0 g 2.2 9.84 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64730 222
SS.LEW-(D1Mco2-D1Mco35)/Jr body weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass not specified 64 days-71 days 39 300.0 g 2.7 16.86 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64715 222
SS-Bcas3em4Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 1 11.56 mEq/d automated urine analysis 0 - 66857 717
SS-Cybaem1Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 2 8.17 mEq/d 4.75 6.71 automated urine analysis 0 - 66860 717
SS-Itga9em1Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 4 9.81 mEq/d 0.91 1.82 automated urine analysis 0 - 66862 717
SS-Alms1em1Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 6 56.84 mg/d 11.13 27.26 automated urine analysis 0 - 66876 717
SS-Gpr183em1Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 6 74.12 mg/d 15.44 37.81 automated urine analysis 0 - 66878 717
SS-Acad10em2Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 13 57.42 mg/d 8.55 30.84 automated urine analysis 0 - 66881 717
SS-Nckap5em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 134.0 mmHg 1.0 1.41 radiotelemetry carotid artery 0 - 66967 717
SS-Itga9em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 144.33 mmHg 8.09 14.01 radiotelemetry carotid artery 0 - 66983 717
SS/HsdMcwiCrl absolute change in mean arterial blood pressure controlled sodium content diet (0.15 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1. arterial blood pressure trait male 35 days-56 days 0 -22.0 mmHg 1.0 tail cuff plethysmography 0.0 0 DR strain is from Charles River Laboratory, Wilmington, MA 67267 731
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 90 days-94 days 13 1.2 ml/min 0.2 0.72 urine creatinine analysis 0.0 0 plasma creatinine analysis 67284 151
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97 days-101 days 19 -1.4 ml/min/g 0.2 0.87 electromagnetic flowmetry 0.0 0 electromagnetic flowmetry 67307 151
SS-Acad10em2Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 12 1.13 g 0.01 0.05 post excision weight measurement 0 - 67002 717
SS-Chr 5BN-Cyp4a2em1Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 3 1.25 g 0.06 0.11 post excision weight measurement 0 - 67016 717
SS.BN-(D13Rat20-D13Got22)/Mcwi-Nckap5em4Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 4 1.13 g 0.06 0.11 post excision weight measurement 0 - 67037 717
SS-Acad10em2Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 5 1.07 g 0.04 0.09 post excision weight measurement 0 - 67053 717
SS.LEW-(D10Chm224-D10Chm6)/Ayd heart right ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart right ventricle mass male 98 days 11 0.59 mg/g 0.01 0.03 post excision weight measurement 0.0 0 64887 226
SS/Jr heart right ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart right ventricle mass male 98 days 16 0.69 mg/g 0.02 0.08 post excision weight measurement 0 0 64893 226
SS.LEW-(D16Rat12-D16Chm23)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 10 3.54 mg/g 0.05 0.16 post excision weight measurement 0 0 64910 226
SS.LEW-(D3Got33-D3Chm68)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 10 2.99 mg/g 0.08 0.25 post excision weight measurement 0 0 64944 226
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 9 and 10 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 76 days-78 days 4 153.0 mmHg 1.6 3.2 intra-aortic abdominal radiotelemetry 86400 0 65060 283
SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 79 and 80 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 147 days-149 days 2 172.9 mmHg 3.5 4.95 intra-aortic abdominal radiotelemetry 86400 0 65071 283
SS/Jr plasma urea nitrogen level controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. blood urea nitrogen amount male 114 days-118 days 4 9.9 mmol/l 2.1 4.2 plasma urea nitrogen analysis 0 0 65088 283
SS.SR-(D7Mco19-D7Mco7)/Jr plasma urea nitrogen level controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. blood urea nitrogen amount male 114 days-118 days 3 11.6 mmol/l 0.6 1.04 plasma urea nitrogen analysis 0 0 65091 283
SS-Ncf2em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 373.83 beats/min 9.78 23.95 radiotelemetry carotid artery 0 - 67116 717
Crl:CD(SD) creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.19 ml/min 0.22 0.48 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51685 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 8 -49.56 beats/min 32.32 91.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51699 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -12.33 beats/min 17.47 52.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51696 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 -63.92 beats/min 13.12 39.35 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51702 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 16 -61.58 beats/min 12.05 48.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51704 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 16 -24.39 beats/min 8.55 34.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51718 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 111.8 mmHg 2.06 6.17 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51732 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 13.75 mmHg 2.88 6.44 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51737 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 24.22 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51771 481
SS.MNS-(Aldoc-D10Mco1)/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 25 and 28 days) Dukhanina OI, et al., Mamm Genome 1997 Apr;8(4):229-35. heart mass not specified 64 days-68 days 38 4.09 g/kg 0.04 0.25 post excision weight measurement 0.0 0 11891 148
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 119.18 mmHg 4.9 12.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51819 481
SS-Chr 20BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 19 7.55 mEq/d 0.78 3.41 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51883 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.33 mg/dl 0.02 0.04 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51897 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 119.18 mmHg 4.08 10.0 vascular fluid filled catheter 0 51909 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 15 131.99 mmHg 3.79 14.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51997 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 91.89 mmHg 3.36 7.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52008 481
FHH-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 9 64.77 mg/d 14.16 42.49 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52114 482
FHH-Chr 20BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 8 282.08 mg/d 60.18 170.22 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52109 482
FHH-Chr 1BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 10 189.0 mg/d 36.58 115.68 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52123 482
FHH-Chr 17BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 10 538.16 mg/d 64.09 202.66 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52125 482
FHH-Chr 8BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 4 21.15 mEq/d 6.39 12.78 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52793 482
FHH-Chr 14BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 7 30.48 mEq/d 3.7 9.8 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52804 482
FHH-Chr 9BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 6 19.96 mEq/d 1.86 4.56 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52823 482
FHH-Chr 16BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 8 8.0 mEq/d 3.18 9.0 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52825 482
LE/BluGill urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 7 23.29 mEq/d 1.27 3.37 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52828 482
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 4.26 g/kg 0.16 0.73 digital scale post excision weight measurement 0 0 12709 282
SS.SHR-(D9Wox16-D9Rat64)/Mco diastolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 103.0 mmHg 1.15 2.57 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13032 305
SS.LEW-(D1Mco36-D1Rat49)/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 307.0 g 3.23 14.44 body weighing method 0 12497 266
SS.LEW-(D1Uia2-D1Rat49)/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 307.0 g 5.02 22.45 body weighing method 0 12500 266
SS.LEW-(D1Rat196-D1Mco36)/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.86 g/kg 0.03 0.15 post excision weight measurement 0 12565 266
SS.LEW-(D18Chm56-D18Rat55)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 7 167.0 mmHg 9.0 23.81 intra-aortic abdominal radiotelemetry aorta 0 12605 269
SS.LEW-(D5Rat130-D5Rat31)/JrMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 21 and 25 days) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. arterial blood pressure trait male 82 days-86 days 32 serial mean 159.0 mmHg vascular fluid filled catheter femoral artery 345600 0 connected to solid-state transducer (Argon Medical Technologies, Athens, TX) 5 hr recording session - 1 min. averages, averaged over 4 days 12618 272
F344-AbatTn(sb-T2/Bart3)2.163Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 5 168.0 g 2.77 6.2 whole body digital scale 0 63639 529
FHH-Adipoqm2Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 15 39.17 cm 0.21 0.79 in vivo ruler method 0 63656 529
FHH-Lcatm1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 13 41.92 cm 0.41 1.47 in vivo ruler method 0 63659 529
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 7 38.86 cm 1.02 2.7 in vivo ruler method 0 63661 529
FHH-Ccr2m1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 7 38.0 cm 0.27 0.71 in vivo ruler method 0 63675 529
F344/NHsd body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 10 27.55 cm 2.79 8.81 in vivo ruler method 0 63680 529
BN-Lcatm3Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 1 37.5 cm in vivo ruler method 0 63702 529
FHH-Egln3m1Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 6 42.58 cm 0.42 1.02 in vivo ruler method 0 63705 529
FHH-Adipoqm3Mcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 5 41.1 cm 0.98 2.19 in vivo ruler method 0 63708 529
FHH-Adipoqm3Mcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass male 70 days-84 days 5 0.68 g 0.05 0.1 digital scale post excision weight measurement 0 63780 529
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 7 130.42 mmHg 2.59 6.85 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52844 482
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 155.24 mmHg 2.9 8.7 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52850 482
FHH-Chr 1BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 9 3.7 ng/ml/h 0.8 2.4 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52924 482
SS-Chr 13BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 20 0.76 mEq/d 0.05 0.24 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52949 482
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 8 1.75 ml/min 0.2 0.58 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52170 482
SS-Chr 19BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 7 1.05 ml/min 0.32 0.85 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52181 482
SS-Chr 2BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 10 1.53 ml/min 0.14 0.44 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52183 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.38 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52191 482
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.4 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52197 482
SS-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.34 mg/dl 0.03 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52213 482
SS-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.45 mg/dl 0.04 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52210 482
SS-Chr 1BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 13 0.32 mg/dl 0.02 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52224 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.41 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52235 482
FHH-Chr 18BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 9 0.66 mEq/d 0.11 0.33 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52312 482
FHH-Chr 17BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 1.18 mEq/d 0.1 0.3 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52323 482
FHH/EurMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 12 1.47 ml/min 0.25 0.85 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52342 482
FHH-Chr 15BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 7 2.4 ml/min 0.46 1.23 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52361 482
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 1.25 g 0.01 0.04 post excision weight measurement 0.0 0 12843 313
SS.LEW-(D1Mco36-D1Mco101)/Mco body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. body mass male 64 days-66 days 30 323.0 g 2.25 12.32 body weighing method 0 0 12877 313
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. body mass male 64 days-66 days 20 309.0 g 2.53 11.31 body weighing method 0 0 12864 313
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 4.04 g/kg 0.03 0.13 post excision weight measurement 0 0 12883 313
SS.LEW-(D1Mco36-D1Mco77)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 3.8 g/kg 0.03 0.15 post excision weight measurement 0 0 12899 313
SS.LEW-(D1Mco36-D1Rat106)/Mco heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 30 3.71 g/kg 0.03 0.17 post excision weight measurement 0 0 12901 313
SHR systolic blood pressure controlled sodium content diet (0.4 %) (for 63 days) Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. arterial blood pressure trait male 91 days 4 serial mean 181.8 mmHg 1.75 3.5 tail cuff photoplethysmography 0 0 UR1000; Ueda average of 3 consistent readings 12582 268
SS.LEW-(D1Mco36-D1Mco101)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 33 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 73 days-75 days 10 178.0 mmHg 1.56 4.93 radiotelemetry 345600 0 C-40 transmitter (Data Sciences International, St. Paul, MN) aveerage of 4-hour interval averages over 4 days 12919 313
SS.BN-(D13Rat115-D13Rat61)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 166.0 mmHg 3.0 10.39 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 65173 15
SS.BN-(D13Rat101-D13Rat46)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 153.0 mmHg 3.5 12.12 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 65186 15
FHH-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 2 100.4 mg/d 43.43 61.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52391 482
FHH-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 6 66.49 mg/d 34.22 83.82 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52394 482
FHH-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 6 70.1 mg/d 24.53 60.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52422 482
FHH-Chr 18BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 442.33 beats/min 16.64 49.92 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52501 482
FHH-Chr 4BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 9 444.42 beats/min 7.91 23.74 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52517 482
FHH-Chr 6BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 177.43 mmHg 5.03 15.09 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52540 482
SS-Chr 6BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 11.6 mg/d 4.48 14.16 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52583 482
SS-Chr 16BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 4.75 mg/d 0.73 2.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52597 482
SS-Chr 15BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 7 139.22 mg/d 35.75 94.58 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52698 482
SS-Chr 1BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 19 24.59 mg/d 2.66 11.61 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52714 482
SS.BN-(D8Rat163-D8Rat81)/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 13 70.6 mg/d 8.59 30.96 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52717 482
SS.SR-(D13Mit9-D13Mit1)/Jr systolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 8 serial mean 136.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11703 119
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 185.0 mmHg 1.97 4.41 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13026 305
SS.SR-(rs65785750-rs106808193)/Opaz systolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 8 167.9 mmHg 3.2 9.05 intra-aortic abdominal radiotelemetry 0.0 0 70353 1358
SS.SR-(rs65785750-rs106808193)/Opaz diastolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 8 116.0 mmHg 3.3 9.33 intra-aortic abdominal radiotelemetry 0.0 0 70356 1358
BN/NHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92 days-94 days 22 100.4 mmol/l 6.5 30.49 unspecified method 0.0 0 urine sodium analysis 69466 151
SS.LEW-(D10Got112-Igfbp4)/Ayd heart left ventricle fractional shortening controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle end-diastolic diameter male 77 days 5 (LVDdLVDs)/LVDd x 100 49.9 % 1.77 3.96 transthoracic echocardiography 0.0 0 68287 542
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) (for 28 days) then controlled sodium content diet (0.3 %) (for 28 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 98 days 4 295.0 pg/ml 54.3 108.6 radioimmunoassay 0.0 0 69657 736
SS/NEisSlc urine total protein excretion rate controlled sodium content diet (0.3 %) (for 28 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. total urine protein amount male 98 days 10 20.9 mg/d 3.3 10.44 urine total protein analysis 0.0 0 69684 736
SS/NEisSlc systolic blood pressure controlled sodium content diet (8 %) (for 28 days) then controlled sodium content diet (0.3 %) (for 28 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. arterial blood pressure trait male 98 days 10 144.0 mmHg 4.0 12.65 tail cuff plethysmography 0.0 0 69687 736
SS.MNS-(D2Mit6-D2Rat166)/Ayd heart left ventricle deoxyribonucleic acid level to body weight ratio controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. heart left ventricle DNA amount male 98 days 4 5.0 ug/g 0.5 1.0 spectrophotometry 0.0 0 69036 1096
BN/NHsdMcwi left kidney wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97 days-101 days 27 0.86 g 0.03 0.16 post excision weight measurement 0.0 0 69505 151
SS/JrHsdMcwi right kidney wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97 days-101 days 21 1.32 g 0.08 0.37 post excision weight measurement 0.0 0 69508 151
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94 days 11 serial mean 140.0 mmHg 7.0 23.22 vascular indwelling catheter method left femoral artery 10800.0 0 69524 151
SS.LEW-(D17Chm14-D17Rat181)/Ayd cerebrospinal fluid chloride level controlled sodium content diet (8 %) (between 8 and 10 days) Huang BS, et al., Hypertension. 2007 Apr 9;. cerebrospinal fluid mineral amount male 43 days-52 days 0 123.0 mmol/l 2.0 chloride ion-selective electrode method 0.0 0 69693 344
SS-Rag1em1Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. blood creatinine amount not specified 84 days 0 0.25 mg/dl 0.03 unspecified method 0.0 0 69285 1057
F344-DccTn(sb-T2/Bart3)2.205Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 6 158.17 U/l 10.73 26.29 standard blood chemistry panel 0 60439 527
FHH-Tlr4m1Mcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70 days-84 days 9 145.67 U/l 7.7 23.1 standard blood chemistry panel 0 60450 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 3 17.8 pg 0.12 0.2 automated blood cell counting method 0 60482 527
FHH-Ccr2m1Mcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 8 17.58 pg 0.09 0.27 automated blood cell counting method 0 60488 527
SS-Sod3m1Mcwi serum total cholesterol level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 10 101.4 mg/dl 9.38 29.66 standard blood chemistry panel 0 60534 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 1 8.44 x 10E6 cells/ul automated blood cell counting method 0 60545 527
FHH-Tgfbr2m2Mcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 14 7.96 x 10E6 cells/ul 0.14 0.51 automated blood cell counting method 0 60550 527
FHH-Lcatm1Mcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 15 7.71 x 10E6 cells/ul 0.09 0.34 automated blood cell counting method 0 60553 527
SS/JrHsdMcwi body weight controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 84 days 28 221.0 g 2.7 14.29 body weighing method 0.0 0 69442 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-91 days 20 serial mean 96.0 mmHg 2.7 12.07 vascular indwelling catheter method left femoral artery 0.0 0 69445 151
SS.SR-(rs106870553-rs63922710)/Opaz mean arterial blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 10 159.6 mmHg 2.8 8.85 intra-aortic abdominal radiotelemetry 0.0 0 70567 1458
SS.SR-(D2Rat352-rs63922710)/Opaz pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 6 50.0 mmHg 1.0 2.45 intra-aortic abdominal radiotelemetry 0.0 0 70561 1458
SS-Cyp1a1em1Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 7 1.42 g 0.05 0.13 digital scale post excision weight measurement 0 - 44363 441
SS-Nppbem2Mcwi-/- right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 16 1.54 g 0.03 0.13 digital scale post excision weight measurement 0 - 44371 441
SS-Prokr1em2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 7 1/3 systolic pressure + 2/3 diastolic pressure 137.57 mmHg 6.49 17.16 radiotelemetry carotid artery 0 - 44411 441
SS-Ulk3em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 11 1/3 systolic pressure + 2/3 diastolic pressure 141.55 mmHg 4.91 16.28 radiotelemetry carotid artery 0 - 44403 441
SS-Cyp1a1em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 7 1/3 systolic pressure + 2/3 diastolic pressure 130.57 mmHg 2.45 6.48 radiotelemetry carotid artery 0 - 44424 441
SS-Plcd3em4Mcwi+/+ left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 3 1.54 g 0.08 0.14 digital scale post excision weight measurement 0 - 44504 441
SS.LEW-(D18Chm90-D18Chm4)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 170.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84481 1438
SS.LEW-(D10Chm224-D10Chm6)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 11 144.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67885 830
SS.LEW-(D10Rat204-D10Rat9)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 5 146.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67888 830
SS.LEW-(D16Rat112-D16Chm60)/Ayd heart left atrium end-systolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left atrium diameter male 77 days 14 4.87 mm 0.16 0.59 transthoracic echocardiography 0.0 0 68303 542
SS.LEW-(D18Rat29-D18Rat55)/Ayd heart left atrium end-diastolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left atrium diameter male 77 days 11 3.6 mm 0.19 0.62 transthoracic echocardiography 0.0 0 68308 542
SS.LEW-(D18Chm41-D18Rat92)/Ayd heart isovolumetric relaxation time controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart muscle relaxation trait male 77 days 8 18.8 ms 0.92 2.61 continuous wave doppler ultrasound 0.0 0 isovolumetric relaxation time 68316 542
SS/Jr heart left atrium fractional shortening controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left atrium diameter male 77 days 40 (LADs - LADd)/ LADs x 100 31.4 % 0.95 5.98 transthoracic echocardiography 0.0 0 heart left atrium fractional shortening 68322 542
SR/JrHsd heart weight to body weight ratio controlled sodium content diet (8 %) (for 56 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. heart mass male 140 days 5 2.67 g/kg 0.03 0.07 post excision weight measurement 0.0 0 67865 810
SS/JrHsd heart weight to body weight ratio controlled sodium content diet (8 %) (for 84 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. heart mass female 168 days 8 3.65 g/kg 0.11 0.31 post excision weight measurement 0.0 0 67868 810
SS.LEW-(D17Chm131-D17Chm93)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 105 days) Crespo K, et al., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e. arterial blood pressure trait male 66 days-86 days 12 serial mean 147.0 mmHg 2.31 8.0 intra-aortic abdominal radiotelemetry 2.0 0 for 2 wks has records that will be duplicated if entered need to add multiple refs once the functionality is in 96580 1665
SS-Chr 12BN.SS-(D12Arb13-D12Mit2)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) then controlled sodium content diet (8 %) (for 7 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 74 days-84 days 8 serial mean 136.0 mmHg 5.0 14.14 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96865 1718
SS-Msraem3Mcwi-/- heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 3 1.14 g 0.05 0.09 digital scale post excision weight measurement 0 - 44563 441
SS-Mstnem1Mcwi+/+ heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70 days-77 days 3 1.14 g 0.01 0.02 digital scale post excision weight measurement 0 - 44560 441
SS-Tcf7l2em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 5 369.8 beats/min 11.89 26.59 radiotelemetry carotid artery 0 - 44584 441
SS-Agtr1aem5Mcwi-/- heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 376.5 beats/min 0.5 0.71 radiotelemetry carotid artery 0 - 44598 441
SS-Plcd3em4Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 343.67 beats/min 10.33 17.9 radiotelemetry carotid artery 0 - 44627 441
SS-Plod1em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 11 362.7 beats/min 7.75 25.71 radiotelemetry carotid artery 0 - 44656 441
SS-Cyp1a1em5Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 357.5 beats/min 0.5 0.71 radiotelemetry carotid artery 0 - 44662 441
SHRSP/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (between 70 and 88 days) and controlled sodium content drinking water (1 %) (between 70 and 88 days) and controlled potassium content diet (6.3 mg/g) (between 70 and 88 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 70 days-88 days 31 100.0 % ex vivo light microscopy 0.0 0 69119 1126
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 18 191.0 mmHg 1.65 7.0 tail cuff plethysmography 0.0 0 69129 1126
SS/JrSeac heart left ventricle end-systolic posterior wall thickness controlled sodium content diet (8 %) (for 84 days) Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. heart left ventricle wall thickness not specified 126 days 5 1.2 mm 0.11 0.24 transthoracic echocardiography 0.0 0 End-systole posterior wall thickening 68586 733
SS/JrSeac heart rate controlled sodium content diet (8 %) (for 84 days) then controlled oxygen content Kreb's solution perfusate Fukushima K, et al., Nucl Med Biol. 2010 Nov;37(8):1005-12. Epub 2010 Sep 1. heart pumping trait not specified 77 days 5 268.0 beats/min 45.62 102.0 isolated perfused heart method 0.0 0 68592 733
LEW peak aortic velocity controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. aorta blood flow trait male 77 days 14 94.6 cm/s 3.1 11.6 pulsed wave doppler ultrasound 0.0 0 peak aortic velocity 68241 542
LEW heart left ventricle anterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle anterior wall thickness male 77 days 14 0.15 mm 0.0 0.01 transthoracic echocardiography 0.0 0 heart left ventricle anterior wall thickness 68249 542
SS.LEW-(D18Chm41-D18Rat92)/Ayd heart left ventricle weight to body weight ratio controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle mass male 77 days 8 2.81 mg/g 0.05 0.14 post excision weight measurement 0.0 0 68260 542
SS.LEW-(D3Chm64-D3Rat17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 195.0 mmHg 9.0 25.46 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84478 1438
SS.LEW-(D1Uia4-D1Rat320)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 6 138.0 mmHg 5.0 12.25 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84500 1438
SS.LEW-(D1Chm64-D1Rat19)(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 118.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84502 1438
SS.MNS-(D2Chm33-Tm2sf1),LEW-(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 7 131.0 mmHg 3.0 7.94 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84510 1438
SS.SHR-(D9Mco72-D9Mco105)/Mco heart left ventricle end-systolic area controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart left ventricle size trait not specified 0 days 7 0.44 cm2 0.05 0.13 echocardiography 0.0 0 69603 749
SS.LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 16 150.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70489 1438
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 4 0.78 x 1000 cells/ul 0.16 0.33 automated blood cell counting method 0 60868 527
FHH/EurMcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 25 0.87 x 1000 cells/ul 0.13 0.64 automated blood cell counting method 0 60871 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 2 0.92 x 1000 cells/ul 0.23 0.33 automated blood cell counting method 0 60874 527
SS-Klf4m3Mcwi serum sodium level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70 days-84 days 8 139.5 mmol/l 1.35 3.82 flame atomic emission spectrometry 0 60904 527
FHH-Tgfbr2m2Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70 days-84 days 11 1.65 g/dl 0.05 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60912 527
BN-Tgfbr2m1Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 3 1.5 g/dl 0.15 0.26 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60915 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70 days-84 days 5 1.9 g/dl 0.1 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 60928 527
FHH-Adipoqm1Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70 days-84 days 8 0.29 mg/dl 0.08 0.22 automated plasma creatinine analysis 0 60992 527
FHH-Adipoqm1Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70 days-84 days 8 0.25 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 61009 527
F344/NHsd plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70 days-84 days 7 0.31 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 61017 527
SS-Tcf7l2em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 138.44 mmHg 2.91 8.73 radiotelemetry carotid artery 0 - 44126 441
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 99.33 % 0.37 1.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56858 522
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.1 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56874 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 79 -6.98 null 0.06 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56955 522
SS-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -7.3 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56980 522
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 7 49.86 % 7.38 19.53 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56996 522
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70 days-84 days 2 26.5 mg/dl 0.5 0.71 standard blood chemistry panel 0 60202 527
FHH-Lcatm1Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 13 14.75 g/dl 0.41 1.5 automated blood cell counting method 0 60300 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 2 14.25 g/dl 0.05 0.07 automated blood cell counting method 0 60306 527
FHH-F10m2Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 16 14.18 g/dl 0.19 0.74 automated blood cell counting method 0 60322 527
F344/NHsd blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 4 15.05 g/dl 1.0 1.99 automated blood cell counting method 0 60330 527
SS-Mmp2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 /3 systolic pressure + 2/3 diastolic pressure 139.0 mmHg radiotelemetry carotid artery 0 - 66472 717
SS-Nox4em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 /3 systolic pressure + 2/3 diastolic pressure 116.33 mmHg 3.67 6.35 radiotelemetry carotid artery 0 - 66478 717
SS-Renem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 /3 systolic pressure + 2/3 diastolic pressure 126.8 mmHg 11.56 25.85 radiotelemetry carotid artery 0 - 66496 717
SS-Gpr183em3Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 7 /3 systolic pressure + 2/3 diastolic pressure 150.14 mmHg 7.29 19.28 radiotelemetry carotid artery 0 - 66499 717
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 5 43.77 mg/d 13.05 29.18 automated urine analysis 0 - 66507 717
SS-Rag1em1Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 3 98.1 mg/d 22.03 38.16 automated urine analysis 0 - 66510 717
SS-Chr 5BN-Cyp4a2em1Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 3 165.66 mg/d 7.8 13.51 automated urine analysis 0 - 66528 717
SS-Cybaem1Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 6 54.67 mg/d 7.61 18.64 automated urine analysis 0 - 66531 717
SS-Apoeem7Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 344.0 beats/min 18.25 31.61 radiotelemetry carotid artery 0 - 66590 717
SS-Mmp2em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 1 370.0 beats/min radiotelemetry carotid artery 0 - 66593 717
SS-Chr 5BN-Cyp4a2em1Mcwi-/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 359.5 beats/min 3.5 4.95 radiotelemetry carotid artery 0 - 66606 717
SS-Nckap5em2Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 2 324.5 beats/min 3.5 4.95 radiotelemetry carotid artery 0 - 66601 717
F344-AbatTn(sb-T2/Bart3)2.163Mcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 4 14.23 g/dl 0.18 0.36 automated blood cell counting method 0 60352 527
SS-Ghsrm3Mcwi mean corpuscular hemoglobin controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 1 19.1 pg automated blood cell counting method 0 60374 527
SS-Cpt2m1Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 1 31.8 g/dl automated blood cell counting method 0 61859 527
FHH-Egln3m1Mcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70 days-84 days 13 3.67 g/dl 0.08 0.3 standard blood chemistry panel 0 61958 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 1 90.0 U/l standard blood chemistry panel 0 61969 527
BN-Lcatm3Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 1 183.0 U/l standard blood chemistry panel 0 62013 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 2 233.0 U/l 30.0 42.43 standard blood chemistry panel 0 62026 527
FHH-Tlr4m1Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70 days-84 days 7 208.71 U/l 25.39 67.19 standard blood chemistry panel 0 62024 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 5 202.2 U/l 38.72 86.59 standard blood chemistry panel 0 62032 527
FHH-Adipoqm1Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70 days-84 days 9 3.31 x 1000 cells/ul 0.35 1.06 automated blood cell counting method 0 62048 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 1 5.52 x 1000 cells/ul automated blood cell counting method 0 62051 527
SS-Nppaem4Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 12 7.91 mEq/d 1.1 3.81 automated urine analysis 0 - 44196 441
SS-Ulk4em3Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 172.5 mmHg 13.73 27.45 radiotelemetry carotid artery 0 - 66633 717
SS-Alms1em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 154.8 mmHg 8.35 18.67 radiotelemetry carotid artery 0 - 66630 717
SR/Hsd absolute change in mean arterial blood pressure controlled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1. arterial blood pressure trait male 35 days-56 days 0 -5.0 mmHg 3.0 tail cuff plethysmography 0.0 0 DR strain is from Charles River Laboratory, Wilmington, MA 67239 731
FHH-Htr1am1Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 18 0.04 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62764 528
F344-DccTn(sb-T2/Bart3)2.205Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 5 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62770 528
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 1 0.01 umol/l wire myography using a Digi-Med tissue force analysis system with force transducer 0 62759 528
F344-DccTn(sb-T2/Bart3)2.205Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62781 528
FHH-Tlr4m1Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 12 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62789 528
FHH-F10m2Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70 days-84 days 12 0.23 mg/dl 0.03 0.11 automated plasma creatinine analysis 0 61027 527
BN-Lcatm3Mcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70 days-84 days 2 0.4 mg/dl 0.0 0.0 automated plasma creatinine analysis 0 61036 527
BN-Tgfbr2m1Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait female 70 days-84 days 3 17.67 mmol/l 1.45 2.52 standard blood chemistry panel 0 61069 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait female 70 days-84 days 4 23.25 mmol/l 1.65 3.3 standard blood chemistry panel 0 61102 527
FHH-Nr4a1m1Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 11 33.06 g/dl 0.52 1.72 automated blood cell counting method 0 61165 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 3 31.73 g/dl 0.42 0.72 automated blood cell counting method 0 61184 527
SS-Ghsrm3Mcwi serum aspartate aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70 days-84 days 1 159.0 U/l standard blood chemistry panel 0 61214 527
SS-Mstnem3Mcwi-/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 1 11.77 mEq/d automated urine analysis 0 - 44220 441
SS-Plcd3em7Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 3 10.3 mEq/d 2.07 3.59 automated urine analysis 0 - 44236 441
SS-Nppbem2Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 16 9.97 mEq/d 0.61 2.45 automated urine analysis 0 - 44247 441
SS-Cdh13em1Mcwi-/- urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 8 9.37 mEq/d 1.21 3.43 automated urine analysis 0 - 44252 441
SS-Prokr1em2Mcwi-/- urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 7 43.52 mg/d 7.99 21.13 automated urine analysis 0 - 44287 441
SS-Ulk3em1Mcwi+/+ urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70 days-77 days 3 69.07 mg/d 18.34 31.77 automated urine analysis 0 - 44295 441
SS-Cyp1a1em5Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 2 1.32 g 0.02 0.03 digital scale post excision weight measurement 0 - 44327 441
SS-Msraem4Mcwi+/+ right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70 days-77 days 5 1.44 g 0.04 0.08 digital scale post excision weight measurement 0 - 44329 441
FHH/EurMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 112 -7.0 null 0.03 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62861 528
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 2 -7.02 null 0.12 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62856 528
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 -7.25 null 0.1 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62886 528
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70 days-84 days 1 130.0 g whole body digital scale 0 62925 528
FHH-Adra1am1Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 9 272.67 g 2.23 6.69 whole body digital scale 0 62952 528
FHH-Adipoqm3Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 3.67 E-7mole 1.0 2.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63037 528
Crl:CD(SD) concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.75 E-7mole 0.27 0.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55982 522
SS-Chr 16BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 4 26.25 % 7.85 15.69 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55996 522
FHH-Adipoqm2Mcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount male 70 days-84 days 7 5.27 g/dl 0.13 0.35 standard blood chemistry panel 0 61237 527
FHH-F10m2Mcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount female 70 days-84 days 12 5.3 g/dl 0.09 0.3 standard blood chemistry panel 0 61253 527
FHH-Adipoqm3Mcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount female 70 days-84 days 6 5.65 g/dl 0.18 0.45 standard blood chemistry panel 0 61270 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70 days-84 days 3 3.3 mmol/l 0.35 0.61 flame atomic emission spectrometry 0 61338 527
F344-AbatTn(sb-T2/Bart3)2.163Mcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70 days-84 days 3 4.17 mmol/l 0.27 0.46 flame atomic emission spectrometry 0 61349 527
FHH-Ccr2m1Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 5 4.02 x 1000 cells/ul 0.39 0.86 automated blood cell counting method 0 61382 527
BN-Lcatm3Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 2 8.9 x 1000 cells/ul 2.5 3.54 automated blood cell counting method 0 61406 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 2 5.7 x 1000 cells/ul 0.5 0.71 automated blood cell counting method 0 61422 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70 days-84 days 5 4.84 x 1000 cells/ul 0.38 0.84 automated blood cell counting method 0 61428 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70 days-84 days 5 8.52 x 1000 cells/ul 1.32 2.95 automated blood cell counting method 0 61431 527
GH/OmrMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.9 E-7mole 0.26 0.79 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54593 522
GH/OmrMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 1.1 E-7mole 0.23 0.65 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54598 522
Crl:CD(SD) logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.84 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54745 522
F344/DuCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 -6.99 null 0.12 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54751 522
FHH-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 77.67 % 5.9 14.46 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54753 522
FHH-Chr 6BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 92.25 % 3.64 10.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54761 522
SS-Chr 16BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -8.98 null 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56019 522
FHH-Chr 1BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -8.5 null 0.12 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56032 522
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 -7.35 null 0.08 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56112 522
SS-Chr 20BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.41 null 0.08 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56117 522
SS-Chr 16BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 -7.68 null 0.08 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56120 522
SS-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.21 null 0.13 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56123 522
FHH-Chr 9BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -8.4 null 0.12 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56161 522
SS-Chr 16BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 5 -7.64 null 0.05 0.1 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56180 522
SS-Chr 18BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 99.7 % 0.3 0.95 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56197 522
SHR/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 96.9 % 1.87 5.92 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56202 522
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 5 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 62268 527
FHH-Slc8a2m1Mcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70 days-84 days 10 102.9 mmol/l 0.81 2.56 standard blood chemistry panel 0 62345 527
FHH-Agtr1bm1Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 14 58.5 mg/dl 1.73 6.49 standard blood chemistry panel 0 62370 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 1 74.0 mg/dl standard blood chemistry panel 0 62383 527
BN-Lcatm3Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 2 38.5 mg/dl 1.5 2.12 standard blood chemistry panel 0 62400 527
FHH-Ghsrm1Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 9 66.11 mg/dl 2.02 6.07 standard blood chemistry panel 0 62397 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 4 74.5 mg/dl 7.1 14.2 standard blood chemistry panel 0 62394 527
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 2 51.0 mg/dl 31.0 43.84 standard blood chemistry panel 0 62402 527
FHH-Adra1am1Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 9 59.67 mg/dl 2.61 7.84 standard blood chemistry panel 0 62413 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70 days-84 days 5 69.2 mg/dl 5.11 11.43 standard blood chemistry panel 0 62425 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 5 86.2 mg/dl 3.25 7.26 standard blood chemistry panel 0 62422 527
SS-Ghsrm3Mcwi serum total bilirubin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 2 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 62427 527
SS-Sod3m1Mcwi serum total bilirubin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70 days-84 days 10 0.1 mg/dl 0.01 0.04 standard blood chemistry panel 0 62430 527
FHH-Slc8a2m1Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 12 122.0 mg/dl 11.39 39.45 standard blood chemistry panel 0 62460 527
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 20 66.8 % 3.88 17.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54841 522
FHH-Chr 1BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 41.5 % 5.45 23.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54846 522
SS-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.08 umol/l 0.03 0.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54893 522
SS-Chr 7BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54904 522
SS-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54923 522
SS-Chr 13BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 0.08 umol/l 0.03 0.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54931 522
FHH-Chr YBN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54942 522
FHH-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54953 522
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 32.2 % 9.09 20.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56271 522
SS-Chr 9BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 14.44 % 3.42 10.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56279 522
SS-Chr 6BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56307 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 54 99.5 % 0.33 2.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56318 522
SS.BN-(D8Rat163-D8Rat81)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 99.3 % 0.37 1.16 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56326 522
SS-Ghsrm3Mcwi body weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 2 190.5 g 4.5 6.36 whole body digital scale 0 63241 529
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70 days-84 days 5 0.13 g 0.01 0.02 digital scale post excision weight measurement 0 63334 529
FHH-Nr0b2m1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 8 0.81 g 0.02 0.05 digital scale post excision weight measurement 0 63336 529
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70 days-84 days 5 0.1 g 0.01 0.02 digital scale post excision weight measurement 0 63331 529
BN-Tgfbr2m1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 3 0.5 g 0.03 0.06 digital scale post excision weight measurement 0 63342 529
SS-Wdr72em2Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 7 305.6 g 9.6 25.4 whole body digital scale 0 - 43493 421
SS-Rasgrp3em1Mcwi-/- urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 10 151.39 mg/d 17.0 53.77 automated urine analysis 0 - 43507 421
SS-Wdr72em2Mcwi+/+ urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70 days-77 days 7 126.17 mg/d 17.74 46.93 automated urine analysis 0 - 43509 421
SS-Adra2aem1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 336.0 beats/min 8.69 17.38 radiotelemetry carotid artery 0 - 43533 421
SS-Hexim2em4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 137.33 mmHg 4.33 7.51 radiotelemetry carotid artery 0 - 43544 421
SS-Agtrapem4Mcwi+/+ urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70 days-77 days 3 10.12 mEq/d 1.35 2.33 automated urine analysis 0 - 43579 421
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 2 0.11 x 1000 cells/ul 0.06 0.08 automated blood cell counting method 0 61680 527
F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 5 0.05 x 1000 cells/ul 0.02 0.04 automated blood cell counting method 0 61688 527
FHH-Nr0b2m1Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 10 0.22 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 61685 527
FHH-Nr4a1m1Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 11 0.15 x 1000 cells/ul 0.05 0.17 automated blood cell counting method 0 61699 527
FHH-F10m1Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 11 0.07 x 1000 cells/ul 0.02 0.08 automated blood cell counting method 0 61691 527
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 1 0.07 x 1000 cells/ul automated blood cell counting method 0 61715 527
F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70 days-84 days 7 0.09 x 1000 cells/ul 0.03 0.07 automated blood cell counting method 0 61735 527
FHH-Adipoqm2Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 9 1.24 g 0.03 0.08 digital scale post excision weight measurement 0 63356 529
FHH-Ghsrm1Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 10 0.95 g 0.02 0.07 digital scale post excision weight measurement 0 63378 529
BN-Lcatm3Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 6 0.55 g 0.02 0.06 digital scale post excision weight measurement 0 63381 529
F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 3 0.6 g 0.03 0.05 digital scale post excision weight measurement 0 63383 529
FHH-Procm1Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 9 0.96 g 0.11 0.34 digital scale post excision weight measurement 0 63432 529
FHH-F10m2Mcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70 days-84 days 10 0.82 g 0.02 0.07 digital scale post excision weight measurement 0 63444 529
FHH-Lcatm1Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 13 24.23 cm 0.19 0.7 in vivo ruler method 0 63505 529
F344/NHsd body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 10 26.9 cm 2.32 7.32 in vivo ruler method 0 63535 529
FHH-F10m1Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 10 24.2 cm 0.17 0.54 in vivo ruler method 0 63537 529
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70 days-84 days 8 19.88 cm 0.21 0.58 in vivo ruler method 0 63532 529
BN-Lcatm3Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 1 22.0 cm in vivo ruler method 0 63548 529
FHH-Slc8a2m1Mcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 15 24.2 cm 0.14 0.53 in vivo ruler method 0 63562 529
SS-Sod3m1Mcwi left kidney wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 13 1.01 g 0.02 0.09 digital scale post excision weight measurement 0 63581 529
SS-Sod3m1Mcwi left kidney wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data kidney mass male 70 days-84 days 11 1.63 g 0.07 0.22 digital scale post excision weight measurement 0 63575 529
BN-Lcatm3Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass male 70 days-84 days 1 253.0 g whole body digital scale 0 63630 529
FHH-Adipoqm3Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 7 209.14 g 4.02 10.64 whole body digital scale 0 63635 529
BN-Lcatm3Mcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 6 158.83 g 3.63 8.89 whole body digital scale 0 63627 529
SS-Agtrapem4Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 359.67 beats/min 18.68 32.35 radiotelemetry carotid artery 0 - 43669 421
SS-Hexim2em4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 10 387.0 beats/min 9.54 30.16 radiotelemetry carotid artery 0 0 - 43688 421
SS-Cpt2m1Mcwi serum urea nitrogen level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70 days-84 days 6 31.5 mg/dl 1.89 4.64 standard blood chemistry panel 0 61762 527
SS-Cpt2m1Mcwi serum urea nitrogen level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70 days-84 days 1 44.0 mg/dl standard blood chemistry panel 0 61767 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70 days-84 days 1 144.0 mmol/l flame atomic emission spectrometry 0 61775 527
F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70 days-84 days 5 135.4 mmol/l 1.75 3.91 flame atomic emission spectrometry 0 61778 527
FHH-Ccr2m1Mcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70 days-84 days 5 138.2 mmol/l 1.74 3.9 flame atomic emission spectrometry 0 61792 527
SS-Chr 6BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 24.25 % 4.97 14.05 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55080 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 33.1 % 6.52 20.6 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55085 522
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -8.34 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55118 522
FHH-Chr 6BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 1.15 g/mg 0.15 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57315 522
FHH-Chr 17BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.67 g/mg 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57334 522
SS-Chr 13BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 0.87 g/mg 0.1 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57359 522
FHH-Chr YBN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 0.79 g/mg 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57370 522
SS-Chr 20BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.48 g/mg 0.05 0.15 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57364 522
FHH-Chr 4BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.39 g/mg 0.15 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57378 522
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 1.25 g/mg 0.12 0.46 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57380 522
FHH-Chr 1BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 28 1.96 g/mg 0.16 0.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57400 522
SHR/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -7.19 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 57405 522
FHH-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.76 E-7mole 0.37 1.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56497 522
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 1.34 E-7mole 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56522 522
SS-Chr 9BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 3.39 E-7mole 0.65 1.96 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56508 522
SS-Chr 16BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 2.8 E-7mole 1.24 4.11 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56541 522
SS-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.53 E-7mole 0.22 0.66 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56544 522
SS-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.63 E-7mole 0.18 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56552 522
BN-Lcatm3Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 5 -7.76 null 0.14 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63098 528
FHH-Adipoqm3Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 5 -8.41 null 0.23 0.52 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63107 528
F344-DccTn(sb-T2/Bart3)2.205Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 -8.19 null 0.16 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter 63104 528
FHH-Adipoqm1Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.71 g/mg 0.05 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63126 528
FHH-Adipoqm1Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 1.46 g/mg 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63142 528
SS-Ghsrm3Mcwi body weight controlled sodium content diet (1 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 2 302.5 g 17.5 24.75 whole body digital scale 0 63194 528
FHH-Adra1am1Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 1.7 g/mg 0.09 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63180 528
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait not specified 64 days-71 days 40 serial mean 216.0 mmHg 2.4 15.18 tail cuff plethysmography tail 0 0 64736 222
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 0.63 E-7mole 0.18 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63222 528
SS-Klf4m3Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 3.8 E-7mole 1.13 3.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 63219 528
FHH-Slc8a2m1Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70 days-84 days 11 2.82 x 1000 cells/ul 0.21 0.7 automated blood cell counting method 0 62060 527
FHH-Adipoqm1Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 8 3.57 x 1000 cells/ul 0.22 0.62 automated blood cell counting method 0 62065 527
FHH-Ccr2m1Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 8 3.88 x 1000 cells/ul 0.3 0.85 automated blood cell counting method 0 62076 527
FHH-Adra1am1Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 8 3.71 x 1000 cells/ul 0.15 0.43 automated blood cell counting method 0 62103 527
FHH-Egln3m1Mcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 6 3.74 x 1000 cells/ul 0.27 0.65 automated blood cell counting method 0 62098 527
FHH-Lcatm1Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70 days-84 days 15 0.14 mg/dl 0.01 0.06 standard blood chemistry panel 0 62131 527
FHH-F10m2Mcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70 days-84 days 12 0.18 mg/dl 0.01 0.05 standard blood chemistry panel 0 62155 527
FHH-Ghsrm1Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 9 0.08 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 62243 527
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 2 0.05 x 1000 cells/ul 0.05 0.06 automated blood cell counting method 0 62235 527
BN-Lcatm3Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 1 0.04 x 1000 cells/ul automated blood cell counting method 0 62249 527
SS-Nppaem4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 11 342.11 beats/min 7.43 24.64 radiotelemetry carotid artery 0 - 43701 441
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 2 0.11 x 1000 cells/ul 0.11 0.15 automated blood cell counting method 0 62262 527
SS-Cyp1a1em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 10 371.3 beats/min 7.54 23.83 radiotelemetry carotid artery 0 - 43705 441
SS-Cdh13em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 364.5 beats/min 16.9 33.81 radiotelemetry carotid artery 0 - 43713 441
SS-Msraem4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 348.5 beats/min 15.51 37.99 radiotelemetry carotid artery 0 - 43715 441
SS-Tcf7l2em1Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 5 338.8 beats/min 17.63 39.42 radiotelemetry carotid artery 0 - 43718 441
SS-Prokr1em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 4 340.5 beats/min 13.05 26.11 radiotelemetry carotid artery 0 - 43734 441
SS-Plcd3em7Mcwi-/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 9 349.89 beats/min 6.75 20.26 radiotelemetry carotid artery 0 - 43739 441
SS-Chr 4BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 204.6 g 3.9 12.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55232 522
Hsd:SD logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 -7.54 null 0.06 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 55246 522
SS-Stk39em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 137.75 mmHg 12.75 25.5 radiotelemetry carotid artery 0 - 43766 441
SS-Nppbem2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 4 1/3 systolic pressure + 2/3 diastolic pressure 134.25 mmHg 5.01 10.01 radiotelemetry carotid artery 0 - 43771 441
SS-Msraem4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 132.0 mmHg 5.51 13.51 radiotelemetry carotid artery 0 - 43777 441
SS-Mstnem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 10 1/3 systolic pressure + 2/3 diastolic pressure 132.3 mmHg 4.88 15.43 radiotelemetry carotid artery 0 - 43779 441
SS-Plekha7em4Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 11 1/3 systolic pressure + 2/3 diastolic pressure 140.09 mmHg 6.7 22.21 radiotelemetry carotid artery 0 - 43790 441
SS-Plekha7em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 131.0 mmHg 5.72 17.16 radiotelemetry carotid artery 0 - 43793 441
SS-Plcd3em7Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 142.78 mmHg 4.69 14.06 radiotelemetry carotid artery 0 - 43801 441
SS-Plcd3em7Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 149.56 mmHg 5.16 15.48 radiotelemetry carotid artery 0 - 43863 441
SS-Tcf7l2em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 138.44 mmHg 2.82 8.46 radiotelemetry carotid artery 0 - 43879 441
SS-Nppaem4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 142.5 mmHg 4.5 6.36 radiotelemetry carotid artery 0 - 43884 441
SS-Agtr1aem1Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 6 334.0 g 6.1 14.9 whole body digital scale 0 - 43889 441
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 13 73.77 % 2.67 9.63 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56703 522
SS-Chr 16BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 3 44.67 % 1.86 3.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56720 522
SS.SR-(Syt2-D13Mit1)/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 24 days) then controlled sodium content diet (4 %) (for 24 days) Zhang QY, et al., Mamm Genome 1997 Sep;8(9):636-41 arterial blood pressure trait not specified 65 days-68 days 25 data obtained at three consistent sessions per day serial mean 219.0 mmHg tail cuff plethysmography 345600 0 66030 650
FHH-Ccr2m1Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 5 43.62 % 2.19 4.9 automated blood cell counting method 0 60644 527
FHH-Ccr2m1Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 8 46.94 % 1.66 4.7 automated blood cell counting method 0 60652 527
FHH-Tlr4m1Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70 days-84 days 7 48.7 % 2.59 6.85 automated blood cell counting method 0 60682 527
F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 5 44.74 % 0.95 2.13 automated blood cell counting method 0 60690 527
SS-Sod3m1Mcwi serum alkaline phosphatase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70 days-84 days 10 63.6 U/l 2.68 8.47 standard blood chemistry panel 0 60698 527
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70 days-84 days 17 56.53 U/l 2.15 8.85 standard blood chemistry panel 0 60703 527
SS-Klf4m3Mcwi blood monocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 7 0.14 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 60709 527
SS-Sod3m1Mcwi blood monocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70 days-84 days 10 0.15 x 1000 cells/ul 0.03 0.1 automated blood cell counting method 0 60714 527
SS-Ghsrm3Mcwi serum phosphate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 2 8.15 mg/dl 0.25 0.35 standard blood chemistry panel 0 60725 527
SS/JrHsdMcwi serum albumin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70 days-84 days 17 3.81 g/dl 0.07 0.28 standard blood chemistry panel 0 60723 527
FHH-Lcatm1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 15 52.75 fl 0.41 1.58 automated blood cell counting method 0 60747 527
FHH-Agtr1bm1Mcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70 days-84 days 14 54.11 fl 0.42 1.57 automated blood cell counting method 0 60750 527
LEW/Crl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 52.44 % 4.83 14.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56826 522
Crl:CD(SD) hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 56.78 % 4.79 14.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56829 522
FHH-Lcatm1Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70 days-84 days 15 17.73 mg/dl 0.52 2.02 standard blood chemistry panel 0 60153 527
FHH-Adipoqm2Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70 days-84 days 7 19.43 mg/dl 1.25 3.31 standard blood chemistry panel 0 60161 527
F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70 days-84 days 3 17.67 mg/dl 0.67 1.15 standard blood chemistry panel 0 60164 527
FHH-Procm1Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70 days-84 days 10 18.31 mg/dl 2.16 6.84 standard blood chemistry panel 0 60172 527
FHH-Adipoqm3Mcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70 days-84 days 6 16.0 mg/dl 1.15 2.83 standard blood chemistry panel 0 60194 527
FHH-Ghsrm1Mcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70 days-84 days 9 47.67 U/l 2.13 6.38 standard blood chemistry panel 0 61475 527
SS-Mthfrem1Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 1 346.0 g whole body digital scale 0 - 66273 717
SS-Gpr183em2Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 11 311.5 g 7.8 25.8 whole body digital scale 0 - 66278 717
SS-Nox4em2Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 3 337.0 g 8.5 14.8 whole body digital scale 0 - 66297 717
SS-Nox4em2Mcwi-/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 2 322.5 g 11.5 16.3 whole body digital scale 0 - 66324 717
SS-Mthfrem1Mcwi-/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 8 333.2 g 10.0 28.2 whole body digital scale 0 - 66321 717
SS-Tgfb1em3Mcwi+/- heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 336.67 beats/min 19.32 33.47 radiotelemetry carotid artery 0 - 66337 717
SS.LEW-(D18Chm41-D18Rat92)/Ayd heart left ventricle posterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle posterior wall thickness male 77 days 8 0.18 mm 0.0 0.01 transthoracic echocardiography 0 0 65117 542
SS.LEW-(D10Got112-Igfbp4)/Ayd heart left ventricle posterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle posterior wall thickness male 77 days 5 0.17 mm 0.01 0.02 transthoracic echocardiography 0 0 65120 542
SS.SR-(D7Mco19-D7Mco7)/Jr both kidneys wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. kidney mass male 114 days-118 days 3 3.79 g 0.14 0.24 post excision weight measurement 0 0 65125 283
WKY.SHRSP-(Asgr1-Vamp2)/Bbb diastolic blood pressure controlled sodium content diet Kreutz R, et al., Proc Natl Acad Sci U S A 1995 Sep 12;92(19):8778-82 arterial blood pressure trait not specified 0 days 9 89.4 mmHg 0.63 1.9 radiotelemetry 0.0 0 67199 116
FHH-Adra1am1Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70 days-84 days 8 7.99 mg/dl 0.22 0.62 standard blood chemistry panel 0 61581 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount female 70 days-84 days 2 8.5 mg/dl 1.0 1.41 standard blood chemistry panel 0 61586 527
FHH-Nr0b2m1Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70 days-84 days 6 17.5 mmol/l 0.85 2.07 standard blood chemistry panel 0 61597 527
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70 days-84 days 2 21.0 mmol/l 0.0 0.0 standard blood chemistry panel 0 61608 527
FHH-F10m1Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70 days-84 days 11 20.18 mmol/l 1.02 3.37 standard blood chemistry panel 0 61619 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70 days-84 days 4 21.75 mmol/l 0.48 0.96 standard blood chemistry panel 0 61636 527
SS-Mstnem3Mcwi+/+ body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 8 332.6 g 2.2 6.2 whole body digital scale 0 - 43924 441
SS-Plekha7em4Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 13 309.6 g 6.8 24.6 whole body digital scale 0 - 43915 441
SS-Slc30a8em2Mcwi-/- body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70 days-77 days 11 318.9 g 5.7 18.8 whole body digital scale 0 - 43945 441
SS-Ulk3em1Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 11 348.27 beats/min 5.62 18.65 radiotelemetry carotid artery 0 - 44032 441
SS-Nppbem4Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 8 352.51 beats/min 9.93 28.1 radiotelemetry carotid artery 0 - 44043 441
SS-Aldh2em2Mcwi-/- heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 6 349.17 beats/min 5.36 13.12 radiotelemetry carotid artery 0 - 44046 441
SS-Plcd3em4Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 333.33 beats/min 7.54 13.05 radiotelemetry carotid artery 0 - 44072 441
SS-Prokr1em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 147.17 mmHg 2.85 6.97 radiotelemetry carotid artery 0 - 44075 441
SS-Nppbem4Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 9 1/3 systolic pressure + 2/3 diastolic pressure 130.89 mmHg 3.37 10.11 radiotelemetry carotid artery 0 - 44083 441
SS-Stk39em2Mcwi-/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 170.0 mmHg radiotelemetry carotid artery 0 - 44091 441
SS-Ulk3em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 1/3 systolic pressure + 2/3 diastolic pressure 128.67 mmHg 6.06 10.5 radiotelemetry carotid artery 0 - 44110 441
SS-Nppbem2Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 14 1/3 systolic pressure + 2/3 diastolic pressure 125.8 mmHg 5.14 19.24 radiotelemetry carotid artery 0 - 44123 441
SS-Aldh2em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 6 1/3 systolic pressure + 2/3 diastolic pressure 154.5 mmHg 11.34 27.78 radiotelemetry carotid artery 0 - 44112 441
SS-Mmp2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 136.0 mmHg radiotelemetry carotid artery 0 - 66412 717
SS-Nckap5em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 5 1/3 systolic pressure + 2/3 diastolic pressure 149.6 mmHg 14.09 31.52 radiotelemetry carotid artery 0 - 66415 717
SS-Gpr183em3Mcwi+/+ heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70 days-77 days 3 349.0 beats/min 1.15 2.0 radiotelemetry carotid artery 0 - 66356 717
SS-Rag1em2Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 1 1/3 systolic pressure + 2/3 diastolic pressure 128.0 mmHg radiotelemetry carotid artery 0 - 66431 717
SS-Cybaem1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 2 1/3 systolic pressure + 2/3 diastolic pressure 140.5 mmHg 24.5 34.65 radiotelemetry carotid artery 0 - 66433 717
SS-Gpr183em3Mcwi-/- mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 7 1/3 systolic pressure + 2/3 diastolic pressure 148.14 mmHg 5.8 15.36 radiotelemetry carotid artery 0 - 66439 717
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70 days-77 days 3 /3 systolic pressure + 2/3 diastolic pressure 140.0 mmHg 14.57 25.24 radiotelemetry carotid artery 0 - 66447 717
F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70 days-84 days 2 229.0 mg/dl 1.0 1.41 standard blood chemistry panel 0 62481 527
F344-DccTn(sb-T2/Bart3)2.205Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 4 138.25 mg/dl 24.59 49.18 standard blood chemistry panel 0 62486 527
BN-Lcatm3Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 2 134.0 mg/dl 7.0 9.9 standard blood chemistry panel 0 62492 527
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70 days-84 days 2 171.5 mg/dl 19.5 27.58 standard blood chemistry panel 0 62508 527
SS-Klf4m3Mcwi blood eosinophil count controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 8 0.1 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 60822 527
SS/JrHsdMcwi blood eosinophil count controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 41 0.07 x 1000 cells/ul 0.02 0.1 automated blood cell counting method 0 60819 527
FHH-Nr0b2m1Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 6 1.19 x 1000 cells/ul 0.17 0.42 automated blood cell counting method 0 60827 527
FHH-Htr1am1Mcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70 days-84 days 13 0.58 x 1000 cells/ul 0.08 0.28 automated blood cell counting method 0 60852 527
SS/NEisSlc plasma renin activity level controlled sodium content diet (0.3 %) (for 91 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. renin activity male 91 days 6 2.49 ng/ml/h 0.63 1.53 radioimmunoassay 0.0 0 100688 2519
SS/NEisSlc kidney weight controlled sodium content diet (0.3 %) (for 91 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. kidney mass male 91 days 6 1.51 g 0.02 0.06 post excision weight measurement 0.0 0 100702 2519
SS/NEisSlc body weight controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. body mass male 91 days 6 319.3 g 7.49 18.35 body weighing method 0.0 0 100699 2519
SS-Renem1Mcwi-/- urine total protein excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. total urine protein amount male 56 days 8 7.83 mg/d 0.95 2.69 urine total protein analysis 0.0 0 98321 2038
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 8 serial mean 201.0 mmHg 7.4 20.93 radiotelemetry 0.0 0 97983 1958
SS/Jr heart rate controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 28 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. heart pumping trait male 68 days-70 days 8 serial mean 397.0 beats/min 9.01 25.48 radiotelemetry 0.0 0 97979 1958
SS.BN-(D12Hmgc7-D12Hmgc6)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 71 days-77 days 6 110.0 mmHg 1.0 2.45 intra-aortic abdominal radiotelemetry 0.0 0 96806 1698
LEW.SS-(D8Chm12-D8Rat15)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 41 days) Crespo K, et al., Circ Cardiovasc Genet. 2015 Aug;8(4):610-7. doi: 10.1161/CIRCGENETICS.114.000965. Epub 2015 May 11. arterial blood pressure trait male 67 days-77 days 5 96.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 864000.0 0 97147 1878
SS.LEW-(D1Mco55-D1Wox6)/Bj systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 64 days-66 days 30 continuous mean 157.0 mmHg 6.0 32.86 tail cuff plethysmography 0.0 0 restrained, 28 degrees C average of 2-3 readings/day over 4 days 96944 1778
LEW/Crl mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 46 days) Crespo K, et al., Circ Cardiovasc Genet. 2015 Aug;8(4):610-7. doi: 10.1161/CIRCGENETICS.114.000965. Epub 2015 May 11. arterial blood pressure trait male 67 days-82 days 9 98.0 mmHg 2.0 6.0 intra-aortic abdominal radiotelemetry abdominal aorta 1296000.0 0 97142 1878
F344-Hsd11b2em1Jmul-/- urine potassium level controlled sodium content diet (0.3 %) then controlled sodium content diet (0.03 %) (between 7 and 10 days) Mullins LJ, et al., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15. urine potassium amount male 168 days 5 1013.7 mmol/l 85.5 191.18 urine potassium analysis 0.0 0 105032 3008
SS/JrTol pulse pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 73 days-75 days 10 41.0 mmHg 5.0 15.81 radiotelemetry 345600.0 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 24 hour 97026 1778
SS.LEW-(D1Rat200-D1Mco136)/Bj pulse pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) and housing in pairs (between 28 and 66 days) then controlled sodium content diet (2 %) (for 24 days) Mell B, et al., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18. arterial blood pressure trait male 73 days-75 days 10 49.0 mmHg 3.0 9.49 radiotelemetry 345600.0 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 24 hour 96962 1778
SHR-Ndufc2em1Mcwi-/+ urine total protein excretion rate controlled protein content diet (19.7 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) and controlled sodium content diet (3.7 mg/g) (for 28 days) Rubattu S, et al., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701. total urine protein amount not specified 70 days 17 24.0 mg/d 1.7 7.0 urine analysis 0.0 0 97936 1938
SS-Plekha7em4Mcwi+/+ heart weight controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. heart mass male 91 days 10 1.54 g 0.08 0.25 post excision weight measurement 0.0 0 105754 3022
SS-Plekha7em4Mcwi+/+ systolic blood pressure controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. arterial blood pressure trait male 91 days 10 213.0 mmHg 8.0 25.3 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 105762 3022
SS-Plekha7em4Mcwi+/+ timed urine volume controlled sodium content diet (8 %) (for 28 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. urine output male 91 days 10 72.03 ml/d 2.71 8.57 urine volume measurement method 0.0 0 105772 3022
SS-Plekha7em4Mcwi+/+ timed urine volume controlled sodium content diet (0.4 %) (for 63 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. urine output male 63 days 10 7.93 ml/d 1.49 4.71 urine volume measurement method 0.0 0 105764 3022
SS-Plekha7em4Mcwi+/+ urine sodium level controlled sodium content diet (8 %) (for 21 days) Endres BT, et al., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18. urine sodium amount male 84 days 10 311.0 mmol/l 23.0 72.73 urine sodium analysis 0.0 0 105780 3022
SR/NEisSlc percent change in heart rate controlled sodium content diet (8 %) (for 28 days) then tempol (4 mol/l) (between 0 and 0 hours) Fujita M, et al., Hypertension. 2007 Aug;50(2):360-7. Epub 2007 Jun 18. heart pumping trait male 63 days-70 days 6 -3.0 % 1.9 4.65 vascular fluid filled catheter 0.0 0 102383 2687
SS-Nppaem4Mcwi-/- heart rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. heart pumping trait male 58 days-67 days 0 serial mean 343.0 beats/min 5.0 intra-aortic abdominal radiotelemetry 32400.0 0 98420 2059
SS-Plod1em1Mcwi-/- urine total protein excretion rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. total urine protein amount male 60 days-69 days 0 147.0 mg/d 12.0 urine total protein analysis 0.0 0 98425 2059
SS-Mthfrem1Mcwi-/+ heart rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. heart pumping trait male 58 days-67 days 0 serial mean 330.0 beats/min 12.0 intra-aortic abdominal radiotelemetry 32400.0 0 98422 2059
SR heart weight to body weight ratio controlled sodium content diet (0.3 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. heart mass male 42 days 5 2.83 g/kg 0.05 0.12 post excision weight measurement 0.0 0 103303 2803
SR body weight controlled sodium content diet (0.3 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. body mass male 42 days 5 185.0 g 7.16 16.0 body weighing method 0.0 0 103297 2803
SR plasma glucose level controlled sodium content diet (0.3 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. blood glucose amount male 42 days 13 104.0 mg/dl 3.61 13.0 plasma glucose analysis 0.0 0 103321 2803
SS plasma glucose level controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 84 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. blood glucose amount male 126 days 12 110.0 mg/dl 5.2 18.0 plasma glucose analysis 0.0 0 103324 2803
SR plasma insulin level controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) Fujii N, et al., Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H760-6. doi: 10.1152/ajpheart.00734.2003. Epub 2004 Mar 18. blood insulin amount male 84 days 11 5.0 mU/l 0.6 2.0 plasma insulin analysis 0.0 0 103329 2803
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 7 serial mean 154.0 mmHg 1.59 4.21 radiotelemetry 0.0 0 97986 1958
SR conduction velocity controlled sodium content diet (6 %) (between 56 and 70 days) then pentobarbital (50 mg/kg) Kamei K, et al., Circ J. 2007 Mar;71(3):390-6. heart electrical impulse conduction trait male 98 days-132 days 7 77.0 cm/min 4.16 11.0 electrocardiography 0.0 0 conduction velocity 103388 2804
SS.BN-(D13Hmgc1041-D13Hmgc885)/Mcwi heart rate controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. heart pumping trait male 58 days-67 days 15 serial mean 384.0 beats/min 6.0 23.24 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-S 98527 2079
SS.BN-(D13Hmgc64-D13Hmgc23)/Mcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Flister MJ, et al., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. urine albumin amount male 91 days 13 121.0 mg/d 17.0 61.29 urine microalbumin analysis 10800.0 0 Strain 9A 98727 2142
SS.SHR-(D9Mco113-D9Mco124)/Bj bone section mineralized tissue surface area controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 3.44 mm2 0.15 micro-computed tomography 0.0 0 98122 1958
SS.BN-(D13Hmgc885-D13Hmgc664)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 58 days-67 days 10 serial mean 144.0 mmHg 3.0 9.49 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 carotid a. to thoracic aorta implant strain 26-R 98498 2079
SS.BN-(D13Got45-D13Rat32)/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60 days-67 days 12 serial mean 145.0 mmHg 4.0 13.86 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry strain 26-L 98564 2098
SR/NEisSlc body weight controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. body mass male 126 days 8 449.0 g 6.0 16.97 body weighing method 0.0 0 102310 2684
SR/NEisSlc heart left ventricle fractional shortening controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. heart left ventricle end-diastolic diameter male 126 days 8 52.6 % 0.7 1.98 transthoracic echocardiography 0.0 0 102316 2684
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic diameter controlled sodium content diet (for 21 days) Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-systolic diameter male 98 days 4 4.18 mm 0.19 0.38 echocardiography 0.0 0 99719 2319
SS.BN-(D13Got42-D13Hmgc664)/Mcwi systolic blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60 days-67 days 5 serial mean 170.0 mmHg 6.0 13.42 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry strain 26-G 98574 2098
SS.BN-(D13Got42-D13Hmgc497)/Mcwi diastolic blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60 days-67 days 7 serial mean 108.0 mmHg 5.0 13.23 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry strain 26-E 98586 2098
SS.BN-(D13Got45-D13Hmgc664)/Mcwi heart rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. heart pumping trait male 60 days-67 days 14 serial mean 370.0 beats/min 6.0 22.45 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry intra-carotid radiotelemetry 98623 2098
SS.BN-(D13Hmgc354-D13Rat32)/Mcwi heart rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. heart pumping trait male 60 days-67 days 15 serial mean 375.0 beats/min 4.0 15.49 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry intra-carotid radiotelemetry 98620 2098
SS-Mthfrem1Mcwi-/+ single kidney wet weight controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. kidney mass male 60 days-69 days 0 1.61 g 0.08 digital scale post excision weight measurement 0.0 0 98455 2059
SS.LEW-(D18Wox7-D18Rat67)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 12 days) Chauvet C, et al., J Hypertens. 2011 Jul;29(7):1320-6. doi: 10.1097/HJH.0b013e32834705e4. arterial blood pressure trait male 68 days 5 serial mean 157.0 mmHg 8.0 17.89 radiotelemetry abdominal aorta 1036800.0 0 telemetry probe averaged over 12 days has records that will be duplicated if entered need to add multiple refs once the functionality is in 96571 1663
WKY/NHsd skin chloride level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 8 50.0 mmol/l 4.4 12.45 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl/h2o 99154 2238
SS/NEisSlc serum potassium level controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. blood potassium amount male 91 days 6 7.33 mmol/l 0.3 0.73 automated serum potassium test 0.0 0 100661 2519
SS.BN-(D13Got42-D13Rat61)/Mcwi systolic blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60 days-67 days 13 serial mean 191.0 mmHg 6.0 21.63 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 0 intra-carotid radiotelemetry strain 26-A 98568 2098
WKY/NHsd mean arterial blood pressure controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then sunitinib (7 mg/kg/d) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. arterial blood pressure trait male 0 days 8 124.0 mmHg 4.0 11.31 intra-aortic radiotelemetry 0.0 0 99190 2238
SS.SR-(D13Mit9-D13Mit1)/Jr heart weight to body weight ratio controlled sodium content diet (1 %) (for 60 days) then controlled sodium content diet (0.2 %) (for 40 days) Zhang QY, et al., Mamm Genome 1997 Sep;8(9):636-41 heart mass male 134 days 11 3.3 g/kg post excision weight measurement 0 0 66114 650
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 210.0 mmHg 3.3 14.76 tail cuff plethysmography 0 0 average of 4days 65479 611
SS.LEW-(D1Uia8-D1Rat211)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 207.0 mmHg 5.8 25.94 tail cuff plethysmography 0 0 average of 4days 65485 611
SS/Jr heart rate controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. heart pumping trait male 73 days-80 days 8 390.0 beats/min 4.1 11.6 intra-aortic abdominal radiotelemetry 10 0 diurnal difference 65503 611
SS.LEW-(D1Rat211-D1Rat18)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 179.0 mmHg 2.9 12.97 tail cuff plethysmography 0 0 average of 4days 65490 611
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-93 days 35 continuous mean 173.0 mmHg 7.0 41.41 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day decrease 66140 229
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 25.0 mmHg 3.0 13.42 vascular indwelling catheter method left femoral artery 0.0 0 67303 151
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 14 serial mean 16.0 mmHg 3.0 11.22 vascular indwelling catheter method left femoral artery 0 0 66149 151
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 199.0 mmHg 5.0 14.14 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65493