SS.LEW-(D10Chm10-D10Rat11)/Ayd |
both kidneys wet weight to body weight ratio |
controlled sodium content diet (2 %) (between 35 and 98 days) |
Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 |
kidney mass |
male |
98 days
| 7 |
|
10.1 |
g/kg |
0.2 |
0.53 |
post excision weight measurement |
|
0 |
0 |
|
|
64784 |
226 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) |
Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. |
arterial blood pressure trait |
male |
66 days-78 days |
16 |
serial mean |
150.0 |
mmHg |
6.0 |
24.0 |
intra-aortic abdominal radiotelemetry |
abdominal aorta |
1036800 |
0 |
telemetry probe model PA-D70, Data Sciences, St. Paul, MN |
average of 24 hour averages over 12 days |
12741 |
304 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (2 %) (between 35 and 98 days) |
Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 |
arterial blood pressure trait |
male |
68 days-98 days |
7 |
|
150.0 |
mmHg |
2.0 |
5.29 |
radiotelemetry |
|
30 |
0 |
|
|
11956 |
226 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
cerebrospinal fluid chloride level |
controlled sodium content diet (8 %) (between 8 and 10 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
cerebrospinal fluid mineral amount |
male |
43 days-52 days |
0 |
|
124.0 |
mmol/l |
2.0 |
|
chloride ion-selective electrode method |
|
0.0 |
0 |
|
|
69692 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) |
Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. |
arterial blood pressure trait |
male |
66 days-80 days |
7 |
|
150.0 |
mmHg |
3.0 |
7.94 |
intra-aortic abdominal radiotelemetry |
abdominal aorta |
0.0 |
0 |
|
|
70436 |
1438 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
heart weight to body weight ratio |
controlled sodium content diet (2 %) (between 35 and 98 days) |
Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 |
heart mass |
male |
98 days
| 7 |
|
3.3 |
g/kg |
0.04 |
0.11 |
post excision weight measurement |
|
0 |
0 |
|
|
12112 |
226 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
heart right ventricle weight to body weight ratio |
controlled sodium content diet (2 %) (between 35 and 98 days) |
Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 |
heart right ventricle mass |
male |
98 days
| 7 |
|
0.57 |
mg/g |
0.01 |
0.03 |
post excision weight measurement |
|
0 |
0 |
|
|
64917 |
226 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
percent change in mean arterial blood pressure |
sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
arterial blood pressure trait |
male |
53 days-61 days |
0 |
|
12.0 |
% |
1.0 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
blood pressure measured after infusion |
% change map |
69731 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) |
Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. |
arterial blood pressure trait |
male |
66 days-80 days |
16 |
|
150.0 |
mmHg |
|
|
intra-aortic abdominal radiotelemetry |
abdominal aorta |
0.0 |
0 |
|
|
70489 |
1438 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
plasma sodium level |
controlled sodium content diet (8 %) (between 8 and 10 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
blood sodium amount |
male |
43 days-52 days |
10 |
|
147.0 |
mmol/l |
3.0 |
9.49 |
sodium ion-selective electrode method |
|
|
0 |
sodium ion-selective electrode |
|
13320 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (2 %) (for 21 days) |
Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. |
arterial blood pressure trait |
male |
56 days-59 days |
7 |
|
150.0 |
mmHg |
|
|
intra-aortic abdominal radiotelemetry |
|
86400.0 |
0 |
|
|
67887 |
830 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
absolute change in heart rate |
sodium ion solution (800 mmol/l) (for 14 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
heart pumping trait |
male |
43 days-50 days |
0 |
|
59.0 |
beats/min |
4.0 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
|
|
69696 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
percent change in heart rate |
sodium ion solution (800 mmol/l) (for 14 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
heart pumping trait |
male |
43 days-50 days |
0 |
|
11.0 |
% |
3.0 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
|
|
69700 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
body weight |
controlled sodium content diet (2 %) (between 35 and 98 days) |
Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 |
body mass |
male |
98 days
| 7 |
|
375.0 |
g |
5.0 |
13.23 |
body weighing method |
|
0 |
0 |
|
|
12061 |
226 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
absolute change in mean arterial blood pressure |
sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
arterial blood pressure trait |
male |
53 days-61 days |
0 |
|
15.0 |
mmHg |
2.0 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
blood pressure measured after infusion |
|
69727 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
absolute change in heart rate |
sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
heart pumping trait |
male |
53 days-61 days |
0 |
|
31.0 |
beats/min |
3.0 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
blood pressure measured after infusion |
|
69735 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
maximum change in heart rate to change in mean arterial blood pressure ratio |
sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
heart pumping trait |
male |
53 days-61 days |
0 |
|
-2.6 |
beats/min/mmHg |
0.2 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
blood pressure measured after infusion |
Maximum slope, bpm/mm Hg |
69743 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
absolute change in mean arterial blood pressure |
sodium ion solution (800 mmol/l) (for 4 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
arterial blood pressure trait |
male |
43 days-51 days |
0 |
|
9.0 |
mmHg |
1.0 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
blood pressure measured after infusion |
1min measurement per 30min, 24 hr average |
68136 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
absolute change in mean arterial blood pressure |
sodium ion solution (800 mmol/l) (for 14 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
arterial blood pressure trait |
male |
53 days-61 days |
0 |
|
7.0 |
mmHg |
1.0 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
blood pressure measured after infusion |
1min measurement per 30min, 24 hr average |
68140 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
body weight gain |
controlled sodium content diet (8 %) (between 8 and 10 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
body mass |
male |
43 days-52 days |
10 |
|
53.0 |
g |
3.0 |
9.49 |
body weighing method |
|
|
0 |
|
|
13316 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
plasma potassium level |
controlled sodium content diet (8 %) (between 8 and 10 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
blood potassium amount |
male |
43 days-52 days |
10 |
|
4.9 |
mmol/l |
0.3 |
0.95 |
potassium ion-selective electrode method |
|
|
0 |
potassium ion-selective electrode |
|
13324 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
hematocrit |
controlled sodium content diet (8 %) (between 8 and 10 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
erythrocyte quantity |
male |
43 days-52 days |
10 |
|
40.0 |
% |
2.0 |
6.32 |
automated standard complete blood count (CBC) test |
|
|
0 |
|
|
13332 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
heart left ventricle weight to body weight ratio |
controlled sodium content diet (2 %) (between 35 and 98 days) |
Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 |
heart left ventricle mass |
male |
98 days
| 7 |
|
2.72 |
mg/g |
0.04 |
0.11 |
post excision weight measurement |
|
0 |
0 |
|
|
64916 |
226 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
percent change in heart rate |
sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
heart pumping trait |
male |
53 days-61 days |
0 |
|
7.0 |
% |
0.4 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
blood pressure measured after infusion |
|
69739 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
change in heart rate to change in mean arterial blood pressure ratio |
sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
heart pumping trait |
male |
53 days-61 days |
0 |
|
-2.2 |
beats/min/mmHg |
0.1 |
|
intra-aortic abdominal radiotelemetry |
|
0.0 |
0 |
blood pressure measured after infusion |
average slope, bpm/mm Hg |
69747 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
plasma chloride level |
controlled sodium content diet (8 %) (between 8 and 10 days) |
Huang BS, et al., Hypertension. 2007 Apr 9;. |
blood chloride amount |
male |
43 days-52 days |
10 |
|
102.0 |
mmol/l |
2.0 |
6.32 |
chloride ion-selective electrode method |
|
|
0 |
chloride ion-selective electrode |
|
13328 |
344 |
SS.LEW-(D10Chm10-D10Rat11)/Ayd |
mean arterial blood pressure |
controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) |
Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. |
arterial blood pressure trait |
male |
66 days-80 days |
6 |
|
151.0 |
mmHg |
3.0 |
7.35 |
intra-aortic abdominal radiotelemetry |
abdominal aorta |
0.0 |
0 |
|
|
70439 |
1438 |