Phenominer Database Results (547 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 206.0 mmHg 4.2 18.78 tail cuff plethysmography 0 0 average of 4days 65482 611
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 20 serial mean 203.6 mmHg 4.2 18.78 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65794 237
SS/Jr systolic blood pressure control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 arterial blood pressure trait male 56 days-57 days 6 serial mean 168.0 mmHg 5.1 12.49 tail cuff plethysmography tail between 7 am and 12 pm 0 11584 104
SS/Jr systolic blood pressure control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 arterial blood pressure trait male 182 days-183 days 6 serial mean 208.0 mmHg 4.6 11.27 tail cuff plethysmography tail 2 days between 7 am and 12 pm 0 11596 104
SS/Jr both kidneys wet weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. kidney mass male 114 days-118 days 4 11.87 g/kg 0.92 1.84 post excision weight measurement 0 0 65100 283
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 36 and 40 days) Joe B, et al., Hum Mol Genet. 2009 Aug 1;18(15):2825-38. Epub 2009 May 7. arterial blood pressure trait male 66 days-70 days 20 serial mean 190.0 mmHg 5.4 24.15 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65309 565
SS/Jr velocity of circumferential fiber shortening controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 29 days) then controlled sodium content diet (4 %) (between 40 and 41 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart left ventricle end-diastolic diameter male 109 days-112 days 6 548.0 %/s 59.0 144.52 transthoracic echocardiography 0 0 65753 283
SS/Jr heart left ventricle end-diastolic diameter controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 29 days) then controlled sodium content diet (4 %) (between 40 and 41 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart left ventricle end-diastolic diameter male 109 days-112 days 6 7.4 mm 0.4 0.98 transthoracic echocardiography 0 0 65741 283
SS/Jr body weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass not specified 64 days-71 days 20 290.0 g 1.9 8.5 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64718 222
SS/Jr body weight controlled sodium content diet (2 %) (for 24 days) Rapp JP, et al., Genomics 1998 Jul 15;51(2):191-6 body mass male 62 days 20 324.0 g 2.5 11.18 body weighing method 0 0 65831 633
SS/Jr both kidneys wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. kidney mass male 70 days-72 days 20 2.9 g 0.05 0.23 post excision weight measurement 0 12316 237
SS/Jr both kidneys wet weight controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. kidney mass male 84 days 12 3.12 g 0.05 0.17 post excision weight measurement 0 0 12338 246
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 20 318.0 g 2.25 10.06 whole body digital scale 0 0 12694 282
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 3.96 g/kg 0.05 0.24 digital scale post excision weight measurement 0 0 12708 282
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 30 3.95 g/kg 0.05 0.26 digital scale post excision weight measurement 0 0 12713 282
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 231.0 mmHg 3.3 14.76 tail cuff plethysmography 0 average of 3-4 consistent readings 12450 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 302.0 g 3.24 14.49 body weighing method 0 12490 266
SS/Jr mean arterial blood pressure controlled sodium content diet (8 %) (between 21 and 25 days) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. arterial blood pressure trait male 82 days-86 days 69 serial mean 187.0 mmHg vascular fluid filled catheter femoral artery 345600 0 connected to solid-state transducer (Argon Medical Technologies, Athens, TX) 5 hr recording session - 1 min. averages, averaged over 4 days 12613 272
SS/Jr heart wet weight controlled sodium content diet (1 %) (for 30 days) then controlled sodium content diet (0.2 %) (for 40 days) Cicila GT, et al., Mamm Genome 1997 Dec;8(12):896-902. heart mass male 100 days 21 1.28 g 0.02 0.11 post excision weight measurement 0 11783 146
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. arterial blood pressure trait male 68 days-70 days 20 serial mean 243.4 mmHg 4.0 17.89 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11801 147
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 20 289.8 g 3.2 14.31 body weighing method 0 11817 147
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.85 g/kg 0.06 0.26 post excision weight measurement 0 12555 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 302.0 g 5.58 body weighing method 0 11974 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.39 g/kg 0.05 0.24 post excision weight measurement 0 11987 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.09 g/kg 0.03 0.14 post excision weight measurement 0 11994 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.24 g/kg 0.09 0.39 post excision weight measurement 0 11995 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.3 g/kg 0.09 0.42 post excision weight measurement 0 11999 221
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 1.25 g 0.01 0.04 post excision weight measurement 0 0 12156 232
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. heart mass male 70 days-72 days 40 1.15 g 0.01 0.06 post excision weight measurement 0 12279 237
SS/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 40 318.6 g 2.6 16.44 body weighing method 0 12282 237
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 1.32 g 0.01 post excision weight measurement 0 12011 205
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 42 days) Saad Y, et al., Hypertension. 2007 arterial blood pressure trait male 81 days-84 days 9 213.0 mmHg 7.47 22.41 intra-aortic abdominal radiotelemetry aorta 345600.0 0 recorded every 5 minutes for 4 days 12072 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Deng AY, et al., Hypertension 1997 Aug;30(2 Pt 1):199-202 heart mass male 68 days 21 4.23 g/kg 0.05 0.25 post excision weight measurement 0 12085 231
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 25 and 28 days) Deng AY, et al., Hypertension 1997 Aug;30(2 Pt 1):199-202 arterial blood pressure trait male 65 days-68 days 21 209.8 mmHg 4.11 18.83 tail cuff photoplethysmography tail 0 average of 4 days, 3 to 4 consistent readings each day, IITC 12099 231
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 arterial blood pressure trait male 64 days-68 days 20 195.0 mmHg 3.35 14.98 tail cuff plethysmography tail 345600 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 12129 232
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 arterial blood pressure trait male 64 days-68 days 20 198.0 mmHg 3.96 17.71 tail cuff plethysmography tail 345600 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 12131 232
SS/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 41 326.2 g 2.1 13.45 body weighing method 0 12305 237
SS/Jr body weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 body mass male 64 days-68 days 20 312.0 g 3.22 14.4 body weighing method 0 0 12143 232
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 20 194.0 mmHg 3.38 15.12 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12808 313
SS/Jr hematocrit controlled sodium content diet (8 %) (between 8 and 10 days) Huang BS, et al., Hypertension. 2007 Apr 9;. erythrocyte quantity male 43 days-52 days 12 40.0 % 3.0 10.39 automated standard complete blood count (CBC) test 0.0 0 13334 344
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.18 g 0.01 0.06 digital scale post excision weight measurement 0 0 12674 282
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.26 g 0.05 0.21 digital scale post excision weight measurement 0 0 12675 282
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 318.0 g 2.09 9.35 body weighing method 0 12947 305
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 20 1.31 g 0.02 0.08 post excision weight measurement 0 12958 305
SS/Jr mean arterial blood pressure controlled sodium content diet (8 %) (for 14 days) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. arterial blood pressure trait male 80 days 8 serial mean 185.0 mmHg radiotelemetry femoral artery 0 connected to solid-state transducer (Argon Medical Technologies, Athens, TX) 5 hr recording session - 1 min. averages, averaged over 4 days 12649 272
SS/Jr heart rate controlled sodium content diet (2 %) (for 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart pumping trait male 75 days-79 days 5 378.0 beats/min 9.18 20.53 intra-aortic abdominal radiotelemetry 172800 0 64986 305
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 23 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. arterial blood pressure trait male 56 days-60 days 12 178.0 mmHg 1.15 4.0 radiotelemetry 86400 0 two 24 hours widely separated periods, data represent averages of all readings over the 24-h measurements 65002 542
SS/Jr heart rate controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart pumping trait male 77 days 40 414.0 beats/min 4.27 27.0 transthoracic echocardiography 0 0 65013 542
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 102.0 mg/d 6.81 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67580 749
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 127.0 mg/d 10.32 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67582 749
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 214.0 mmHg 5.26 tail cuff plethysmography 0.0 0 67515 749
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. body mass not specified 0 days 0 353.0 g 6.24 body weighing method 0.0 0 67537 749
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 1.53 g 0.02 post excision weight measurement 0.0 0 67556 749
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.16 g/kg 0.07 post excision weight measurement 0.0 0 67566 749
SS/Jr body weight control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 body mass male 182 days-183 days 6 485.0 g 11.9 29.15 body weighing method 0 0 65446 104
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 34.85 % 2.94 10.18 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69065 1096
SS/Jr logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) then NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -7.92 null 0.36 1.25 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69071 1096
SS/Jr blood vessel contractile force measurement Kreb's solution perfusate then potassium chloride solution (40 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 1.59 g 0.11 0.38 tissue force analysis utilizing a force transducer 0.0 0 69048 1096
SS/Jr absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 23.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69729 344
SS/Jr percent change in heart rate sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 10.0 % 0.3 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69741 344
SS/Jr heart left ventricle weight to body weight ratio controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle mass male 77 days 40 2.99 mg/g 0.06 0.38 post excision weight measurement 0.0 0 68258 542
SS/Jr heart left ventricle end-systolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle end-systolic diameter male 77 days 40 3.55 mm 0.09 0.56 transthoracic echocardiography 0.0 0 68274 542
SS/Jr heart left ventricle end-diastolic area controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart left ventricle size trait not specified 0 days 6 0.62 cm2 0.11 0.27 echocardiography 0.0 0 69596 749
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 142.0 mmHg 1.34 3.0 intra-aortic thoracic radiotelemetry 0.0 0 103169 2787
SS/Jr respiration rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 123.0 breaths/min 1.34 3.0 spirometry 0.0 0 103175 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.9 and 1 hours) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 4 sampling once per minute 486.0 beats/min 4.5 9.0 intra-aortic thoracic radiotelemetry 0.0 25 min 103194 2787
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 4 sampling once per minute 135.0 mmHg 2.0 4.0 intra-aortic thoracic radiotelemetry 0.0 0 103204 2787
SS/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then atropine (1 mg/kg) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 4 sampling once per minute 88.0 breaths/min 6.0 12.0 spirometry 0.0 0 103208 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 84 days 5 411.0 beats/min 19.68 44.0 vascular transducer tipped catheter 0.0 0 103147 2787
SS/Jr mean arterial blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 7 serial mean 174.0 mmHg 1.74 4.6 radiotelemetry 0.0 0 97989 1958
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 7 serial mean 213.0 mmHg 2.05 5.42 radiotelemetry 0.0 0 97982 1958
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 6 serial mean 149.0 mmHg 3.55 8.7 radiotelemetry 0.0 0 97988 1958
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 20 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 10 mean of 3 samples of undefined duration between 7am and 12pm serial mean 168.0 mmHg 5.3 16.76 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102306 2661
SS/Jr heart weight to body weight ratio controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. heart mass male 63 days 10 3.1 g/kg 0.06 0.19 post excision weight measurement 0.0 0 103241 2802
SS/Jr single kidney wet weight to body weight ratio controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. kidney mass male 63 days 15 6.39 g/kg 0.13 0.5 post excision weight measurement 0.0 0 103244 2802
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 10 153.0 mmHg 7.0 22.14 vascular transducer tipped catheter 0.0 0 103253 2802
SS/Jr plasma triglyceride level controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. blood triglyceride amount male 63 days 15 1.2 mmol/l 0.16 0.62 plasma triglyceride analysis 0.0 0 103260 2802
SS/Jr plasma total cholesterol level controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. blood cholesterol amount male 63 days 10 111.97 mg/dl 13.51 42.73 plasma total cholesterol measurement test 0.0 0 103265 2802
SS/Jr hematocrit controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte quantity male 63 days 10 47.0 % 2.2 6.96 hematocrit analysis 0.0 0 103269 2802
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 1.68 g 0.06 post excision weight measurement 0.0 0 67552 749
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.24 g/kg 0.1 post excision weight measurement 0.0 0 67575 749
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 197.0 mmHg 3.85 tail cuff plethysmography 0.0 0 67513 749
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. body mass not specified 0 days 0 334.0 g 5.6 body weighing method 0.0 0 67531 749
SS/Jr plasma chloride level controlled sodium content diet (8 %) (between 8 and 10 days) Huang BS, et al., Hypertension. 2007 Apr 9;. blood chloride amount male 43 days-52 days 12 105.0 mmol/l 2.0 6.93 chloride ion-selective electrode method 0 chloride ion-selective electrode 13330 344
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. heart mass male 70 days-72 days 40 1.13 g 0.01 0.06 post excision weight measurement 0 12254 237
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 19 serial mean 190.9 mmHg 3.6 15.69 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65800 237
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 47 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 114 days-116 days 3 158.2 mmHg 3.9 6.75 intra-aortic abdominal radiotelemetry 86400 0 65066 283
SS/Jr plasma urea nitrogen level controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. blood urea nitrogen amount male 114 days-118 days 4 9.9 mmol/l 2.1 4.2 plasma urea nitrogen analysis 0 0 65088 283
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. body mass male 114 days-118 days 4 357.0 g 26.0 52.0 body weighing method 0 0 65096 283
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 arterial blood pressure trait male 64 days-66 days 0 197.0 mmHg 3.74 tail cuff plethysmography 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 11907 205
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. body mass male 64 days-66 days 20 309.0 g 2.53 11.31 body weighing method 0 0 12864 313
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 20 297.0 g 3.75 16.77 whole body digital scale 0 0 12690 282
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 20 serial mean 206.6 mmHg 2.4 10.73 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65793 237
SS/Jr percent change in heart rate sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 43 days-50 days 0 10.0 % 1.0 intra-aortic abdominal radiotelemetry 0.0 0 69702 344
SS/Jr ejection fraction controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. cardiac output trait male 77 days 40 86.0 % 0.65 4.14 transthoracic echocardiography 0.0 0 peak aortic velocity 68290 542
SS/Jr logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -8.22 null 0.26 0.9 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69067 1096
SS/Jr logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then phenylephrine (1-100 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -7.26 null 0.06 0.21 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer EC50 value is probably moles/liter 69054 1096
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait not specified 64 days-71 days 19 serial mean 205.0 mmHg 5.9 25.72 tail cuff plethysmography tail 0 0 64741 222
SS/Jr calculated heart weight control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 heart mass male 183 days 6 adjusted heart weight for differences in body weight by regression analysis using programs from SPSS 1.68 g 0.02 0.04 post excision weight measurement 0 0 65448 104
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 8 serial mean 201.0 mmHg 7.4 20.93 radiotelemetry 0.0 0 97983 1958
SS/Jr ouabain- and bumetanide-resistant red blood cell Na+ import rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 15 3803.0 umol/l/h 134.0 518.98 Na+ passive permeability assay 0.0 0 111043 2802
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 139.0 mmHg 2.24 5.0 intra-aortic thoracic radiotelemetry 0.0 0 103173 2787
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 3 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 11 mean of 3 samples of undefined duration between 7am and 12pm serial mean 146.0 mmHg 2.1 6.96 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102295 2661
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 27 and 28 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 67 days-69 days 5 181.0 mmHg 3.6 8.05 intra-aortic abdominal radiotelemetry 86400 0 65041 283
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 47 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 114 days-116 days 3 219.3 mmHg 4.2 7.27 intra-aortic abdominal radiotelemetry 86400 0 65050 283
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 27 and 28 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 67 days-69 days 5 125.2 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry 86400 0 65057 283
SS/Jr blood uric acid level controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. blood uric acid amount male 84 days 8 2.8 mg/dl 0.11 0.31 automated blood analysis 0 0 65784 246
SS/Jr body weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass not specified 64 days-71 days 40 304.0 g 1.6 10.12 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64716 222
SS/Jr heart left ventricle end-systolic diameter controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 29 days) then controlled sodium content diet (4 %) (between 40 and 41 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart left ventricle end-systolic diameter male 109 days-112 days 6 4.2 mm 0.4 0.98 transthoracic echocardiography 0 0 65745 283
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 42 days) Palijan A, et al., Physiol Genomics 2003 Sep 29;15(1):1-8. arterial blood pressure trait male 66 days-77 days 15 measurement taken every 4 hours during a 24-hour period serial mean 175.0 mmHg 3.0 11.62 radiotelemetry 86400.0 0 65559 615
SS/Jr plasma sodium level controlled sodium content diet (8 %) (between 8 and 10 days) Huang BS, et al., Hypertension. 2007 Apr 9;. blood sodium amount male 43 days-52 days 12 147.0 mmol/l 2.0 6.93 sodium ion-selective electrode method 0 sodium ion-selective electrode 13322 344
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.23 g 0.02 0.08 digital scale post excision weight measurement 0 0 12663 282
SS/Jr heart wet weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 46 1.23 g 0.01 0.07 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64743 222
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 216.0 mmHg 5.1 22.81 tail cuff plethysmography 0 0 average of 4days 65480 611
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 20 serial mean 210.6 mmHg 3.4 15.21 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65792 237
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 3.89 g/kg 0.02 0.1 post excision weight measurement 0 0 12884 313
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 43 and 47 days) Grondin M, et al., Physiol Genomics 2005 Mar 21;21(1):112-6. Epub 2005 Jan 4. arterial blood pressure trait male 88 days-92 days 19 169.0 mmHg 4.0 17.44 intra-aortic abdominal radiotelemetry 0 measure every 2 min for 24 hrs 12422 261
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.31 g 0.02 0.07 post excision weight measurement 0 regression of heart weight on body weight 12516 266
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 4.33 g/kg 0.04 0.19 post excision weight measurement 0 12542 266
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.31 g/kg 0.06 0.27 post excision weight measurement 0 11990 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.42 g/kg 0.06 0.27 post excision weight measurement 0 12001 221
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 20 203.0 mmHg 2.98 13.33 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12809 313
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 30 198.0 mmHg 1.78 9.75 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12810 313
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 44 serial mean 190.0 mmHg 1.61 10.68 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13116 282
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 30 serial mean 206.0 mmHg 2.23 12.21 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13125 282
SS/Jr both kidneys wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. kidney mass male 70 days-72 days 40 3.03 g 0.06 0.38 post excision weight measurement 0 12314 237
SS/Jr both kidneys wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. kidney mass male 70 days-72 days 41 3.04 g 0.03 0.19 post excision weight measurement 0 12318 237
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 20 303.0 g 2.86 12.79 whole body digital scale 0 0 12688 282
SS/Jr body weight controlled sodium content diet (0.3 %) (for 30 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 20 311.0 g 2.11 9.44 whole body digital scale 0 0 12689 282
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 4.26 g/kg 0.07 0.3 digital scale post excision weight measurement 0 0 12707 282
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 21 serial mean 177.0 mmHg 6.0 27.5 intra-aortic abdominal radiotelemetry abdominal aorta 1036800.0 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12737 304
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 4.29 g/kg 0.1 0.45 post excision weight measurement 0 0 12216 232
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 4.08 g/kg 0.05 0.22 post excision weight measurement 0 0 12219 232
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. heart mass male 70 days-72 days 20 1.21 g 0.01 0.06 post excision weight measurement 0 12260 237
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. heart mass male 70 days-72 days 20 1.12 g 0.02 0.07 post excision weight measurement 0 12275 237
SS/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 40 298.6 g 2.0 12.65 body weighing method 0 12285 237
SS/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 20 288.1 g 2.8 12.52 body weighing method 0 12287 237
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 7 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Cicila GT, et al., Mamm Genome 1999 Feb;10(2):112-6. arterial blood pressure trait male 61 days-65 days 20 serial mean 202.7 mmHg 3.7 16.55 tail cuff plethysmography 0 average of 12 readings from 4 sessions 11775 145
SS/Jr body weight controlled sodium content diet (0.2 %) (for 7 days) then controlled sodium content diet (2 %) (for 28 days) Cicila GT, et al., Mamm Genome 1999 Feb;10(2):112-6. body mass male 65 days 20 306.8 g 4.6 20.57 body weighing method 0 0 11779 145
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 7 days) then controlled sodium content diet (4 %) (for 24 days) Cicila GT, et al., Mamm Genome 1997 Dec;8(12):896-902. arterial blood pressure trait female 61 days 24 serial mean 250.1 mmHg 4.9 24.0 tail cuff plethysmography 0 11792 146
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. arterial blood pressure trait male 68 days-70 days 20 serial mean 224.9 mmHg 4.8 21.47 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11795 147
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 20 289.4 g 2.0 8.94 body weighing method 0 11805 147
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 20 297.7 g 2.5 11.18 body weighing method 0 11823 147
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. arterial blood pressure trait male 68 days-70 days 19 serial mean 221.8 mmHg 2.9 12.64 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11825 147
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 25 and 28 days) Dukhanina OI, et al., Mamm Genome 1997 Apr;8(4):229-35. heart mass not specified 64 days-68 days 41 4.06 g/kg 0.04 0.26 post excision weight measurement 0 11843 148
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.21 g 0.01 0.03 digital scale post excision weight measurement 0 0 12673 282
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 339.0 g 3.0 13.42 body weighing method 0 12945 305
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 343.0 g 5.2 23.26 body weighing method 0 12948 305
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 16 1.33 g 0.02 0.09 post excision weight measurement 0 12963 305
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 3 4.32 g/kg 0.24 0.42 post excision weight measurement 0 12984 305
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 64 days-70 days 20 serial mean 207.0 mmHg 4.1 18.34 tail cuff photoplethysmography tail 345600 0 28 degrees C average of 3 averaged readings per day over 4 days 13000 305
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.24 g/kg 0.03 0.15 post excision weight measurement 0 12003 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 4.12 g/kg 0.04 post excision weight measurement 0 12045 205
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 209.0 mmHg 2.97 13.28 tail cuff plethysmography 0 average of 3-4 consistent readings 12452 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 314.0 g 1.72 7.69 body weighing method 0 12486 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 304.0 g 2.95 13.19 body weighing method 0 12488 266
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 197.0 mmHg 3.53 tail cuff plethysmography 0.0 0 67511 749
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 263.0 mmHg 5.6 tail cuff plethysmography 0.0 0 67517 749
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 1.27 g 0.02 post excision weight measurement 0.0 0 67546 749
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.09 g/kg 0.08 post excision weight measurement 0.0 0 67564 749
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 31 and 32 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. total urine protein amount male 71 days-73 days 20 91.29 mg/d 6.05 27.06 pyrogallol red-molybdate complex-based urine total protein analysis 86400 0 64992 305
SS/Jr heart left ventricle wet weight controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle mass male 77 days 40 0.91 g 0.01 0.09 post excision weight measurement 0 0 65028 542
SS/Jr calculated kidney weight control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 kidney mass male 183 days 6 adjusted organ weight for differences in body weight by regression analysis using programs from SPSS 3.31 g 0.14 0.34 post excision weight measurement 0 0 65450 104
SS/Jr serum total cholesterol level controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. blood cholesterol amount male 84 days 8 119.0 mg/dl 5.3 14.99 automated blood analysis 0 0 64814 246
SS/Jr body weight control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 body mass male 140 days-141 days 6 451.0 g 18.5 45.32 body weighing method 0 0 65444 104
SS/Jr systolic blood pressure controlled sodium content diet (1 %) (for 60 days) then controlled sodium content diet (0.2 %) (between 41 and 44 days) Zhang QY, et al., Mamm Genome 1997 Sep;8(9):636-41 arterial blood pressure trait both 131 days-134 days 21 data obtained at three consistent sessions per day serial mean 244.0 mmHg tail cuff plethysmography 345600 0 65963 650
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 10 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Zhang QY, et al., Mamm Genome 1997 Sep;8(9):636-41 arterial blood pressure trait both 65 days-68 days 20 data obtained at three consistent sessions per day serial mean 199.0 mmHg tail cuff plethysmography 345600 0 65967 650
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 10 days) then controlled sodium content diet (2 %) (between 41 and 44 days) Zhang QY, et al., Mamm Genome 1997 Sep;8(9):636-41 arterial blood pressure trait male 81 days-84 days 20 data obtained at three consistent sessions per day serial mean 231.0 mmHg tail cuff plethysmography 345600 0 65971 650
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 10 days) then controlled sodium content diet (4 %) (between 24 and 28 days) Zhang QY, et al., Mamm Genome 1997 Sep;8(9):636-41 arterial blood pressure trait both 65 days-68 days 38 data obtained at three consistent sessions per day serial mean 260.0 mmHg tail cuff plethysmography 345600 0 65974 650
SS/Jr urine albumin excretion rate controlled sodium content diet (0.2 %) Poyan Mehr A, et al., Physiol Genomics 2003 Aug 15;14(3):209-16. urine albumin amount not specified 56 days 12 69.96 mg/d enzyme linked immunosorbent assay urine 0.0 0 rat albumin ELISA 67824 335
SS/Jr logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then phenylephrine (1-100 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -7.6 null 0.05 0.17 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer EC50 value is probably moles/liter 69058 1096
SS/Jr peak aortic velocity controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. aorta blood flow trait male 77 days 40 110.5 cm/s 2.59 16.4 pulsed wave doppler ultrasound 0.0 0 peak aortic velocity 68242 542
SS/Jr heart left ventricle end-systolic area controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart left ventricle size trait not specified 0 days 6 0.25 cm2 0.07 0.17 echocardiography 0.0 0 69602 749
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 16 177.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 68086 830
SS/Jr maximum rate of positive change in left ventricular blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 LVdP/dtmax 13200.0 mmHg/s 1207.48 2700.0 vascular transducer tipped catheter 0.0 0 E3 X mmHg/s 103153 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 368.0 beats/min 3.13 7.0 intra-aortic thoracic radiotelemetry 0.0 0 103155 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 343.0 beats/min 5.81 13.0 intra-aortic thoracic radiotelemetry 0.0 0 103157 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 428.0 beats/min 10.73 24.0 intra-aortic thoracic radiotelemetry 0.0 25 min 103163 2787
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 142.0 mmHg 2.24 5.0 intra-aortic thoracic radiotelemetry 0.0 0 103171 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.6 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 4 sampling once per minute 455.0 beats/min 2.5 5.0 intra-aortic thoracic radiotelemetry 0.0 0 103188 2787
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 4 sampling once per minute 135.0 mmHg 1.5 3.0 intra-aortic thoracic radiotelemetry 0.0 0 103202 2787
SS/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 4 sampling once per minute 128.0 breaths/min 3.5 7.0 spirometry 0.0 0 103210 2787
SS/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.4 hours) then ambient air (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 4 sampling once per minute 96.0 breaths/min 4.0 8.0 spirometry 0.0 0 103212 2787
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 10 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 10 mean of 3 samples of undefined duration between 7am and 12pm serial mean 152.0 mmHg 4.4 13.91 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102298 2661
SS/Jr bone section mineralized tissue surface area controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 5.3 mm2 0.17 micro-computed tomography 0.0 0 98121 1958
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 15 131.0 mmHg 3.0 11.62 vascular transducer tipped catheter 0.0 0 103252 2802
SS/Jr diastolic blood pressure controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 10 124.0 mmHg 6.0 18.97 vascular transducer tipped catheter 0.0 0 103257 2802
SS/Jr hematocrit controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte quantity male 63 days 15 48.8 % 0.5 1.94 hematocrit analysis 0.0 0 103268 2802
SS/Jr ouabain-sensitive red blood cell Na+ export rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 15 3908.0 umol/l/h 104.0 402.79 Na+/K+ ATPase activity assay 0.0 0 111035 2802
SS/Jr artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.06 mm2 0.02 0.05 ex vivo light microscopy with digital image analysis 0.0 0 110472 3107
SS/Jr artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 28.3 % 6.87 21.72 ex vivo light microscopy with digital image analysis 0.0 0 110483 3107
SS/Jr bumetanide-sensitive red blood cell Na+ export rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 10 614.0 umol/l/h 160.0 505.96 Na-K-Cl cotransport activity assay 0.0 0 111040 2802
SS/Jr ouabain-sensitive red blood cell K+ import rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 10 6084.0 umol/l/h 562.0 1777.2 Na+/K+ ATPase activity assay 0.0 0 111048 2802
SS/Jr ouabain- and bumetanide-resistant red blood cell K+ import rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 15 424.0 umol/l/h 14.0 54.22 Na+ passive permeability assay 0.0 0 111055 2802
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.19 g/kg 0.08 post excision weight measurement 0.0 0 67562 749
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 102.0 mg/d 6.81 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67588 749
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 4.2 g/kg 0.07 post excision weight measurement 0 12043 205
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. heart mass male 70 days-72 days 20 1.27 g 0.02 0.07 post excision weight measurement 0 12262 237
SS/Jr body weight controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. body mass male 84 days 12 375.0 g 6.0 20.78 body weighing method 0.0 0 12331 246
SS/Jr diastolic blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 42 days) Palijan A, et al., Physiol Genomics 2003 Sep 29;15(1):1-8. arterial blood pressure trait male 66 days-77 days 15 measurement taken every 4 hours during a 24-hour period serial mean 150.0 mmHg 4.0 15.49 radiotelemetry 86400.0 0 65553 615
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 40 serial mean 213.0 mmHg 2.5 15.81 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65790 237
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 20 307.0 g 3.23 14.44 whole body digital scale 0 0 12693 282
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 158.0 mmHg 1.76 3.94 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13035 305
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 9 and 10 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 76 days-78 days 4 153.0 mmHg 1.6 3.2 intra-aortic abdominal radiotelemetry 86400 0 65060 283
SS/Jr urine albumin excretion rate controlled sodium content diet (0.2 %) Poyan Mehr A, et al., Physiol Genomics 2003 Aug 15;14(3):209-16. urine albumin amount not specified 28 days 12 4.7 mg/d enzyme linked immunosorbent assay urine 0.0 0 rat albumin ELISA 13281 335
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 20 4.19 g/kg 0.04 0.2 post excision weight measurement 0 12978 305
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 64 days-70 days 20 serial mean 214.0 mmHg 5.61 25.09 tail cuff photoplethysmography tail 345600 0 28 degrees C average of 3 averaged readings per day over 4 days 13018 305
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.31 g 0.02 0.07 digital scale post excision weight measurement 0 0 12667 282
SS/Jr heart left ventricle deoxyribonucleic acid content to body weight ratio controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. heart left ventricle DNA amount male 98 days 11 5.8 ug/g 0.6 1.99 spectrophotometry 0.0 0 69039 1096
SS/Jr absolute change in heart rate sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 43 days-50 days 0 54.0 beats/min 6.0 intra-aortic abdominal radiotelemetry 0.0 0 69698 344
SS/Jr heart isovolumetric relaxation time controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart muscle relaxation trait male 77 days 40 20.1 ms 0.41 2.57 continuous wave doppler ultrasound 0.0 0 isovolumetric relaxation time 68314 542
SS/Jr heart left atrium fractional shortening controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left atrium diameter male 77 days 40 (LADs - LADd)/ LADs x 100 31.4 % 0.95 5.98 transthoracic echocardiography 0.0 0 heart left atrium fractional shortening 68322 542
SS/Jr mean arterial blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 6 serial mean 175.0 mmHg 3.75 9.19 radiotelemetry 0.0 0 97991 1958
SS/Jr bone section trabecular thickness controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. cancellous bone morphology trait male 66 days-70 days 0 0.07 mm 0.0 micro-computed tomography 0.0 0 98117 1958
SS/Jr heart rate controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. heart pumping trait male 73 days-80 days 8 390.0 beats/min 4.1 11.6 intra-aortic abdominal radiotelemetry 10 0 diurnal difference 65503 611
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 172.0 mmHg 5.0 14.14 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65496 611
SS/Jr pulse pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 52.0 mmHg 3.4 9.62 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65495 611
SS/Jr absolute change in systolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) then controlled exposure to darkness then controlled exposure to ambient light Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 22.6 mmHg 1.05 2.97 intra-aortic abdominal radiotelemetry 10 0 diurnal difference 65497 611
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 20 222.0 mmHg 5.01 22.41 tail cuff plethysmography 0.0 0 67311 749
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 64 days-70 days 20 serial mean 203.0 mmHg 4.11 18.38 tail cuff photoplethysmography tail 345600 0 28 degrees C average of 3 averaged readings per day over 4 days 13016 305
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 36 and 40 days) Joe B, et al., Hum Mol Genet. 2009 Aug 1;18(15):2825-38. Epub 2009 May 7. heart mass male 66 days-70 days 20 serial mean 1.28 g 0.02 0.08 post excision weight measurement 345600 0 / 65313 565
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (for 63 days) Moujahidine M, et al., Hypertens Res 2004 Mar;27(3):203-12. arterial blood pressure trait male 98 days 16 serial mean 171.0 mmHg 4.0 16.0 radiotelemetry 120 0 average of 6hr 65475 610
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 79 and 80 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 147 days-149 days 1 152.5 mmHg 1.7 1.7 intra-aortic abdominal radiotelemetry 86400 0 65069 283
SS/Jr body weight controlled sodium content diet (4 %) (for 14 days) Garrett MR, et al., Physiol Genomics 2000 Jun 29;3(1):33-8. body mass male 53 days-67 days 10 297.0 g 5.0 15.81 body weighing method 0 0 66107 691
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 39 serial mean 191.8 mmHg 2.6 16.24 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65801 237
SS/Jr systolic blood pressure controlled sodium content diet (4 %) (for 28 days) Garrett MR, et al., Physiol Genomics 2000 Jun 29;3(1):33-8. arterial blood pressure trait male 81 days 10 238.0 mmHg 7.0 22.14 tail cuff plethysmography 0 0 66119 691
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 20 serial mean 218.0 mmHg 3.1 13.86 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13083 282
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 20 serial mean 196.0 mmHg 2.53 11.31 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13119 282
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 202.0 mmHg 1.72 7.69 tail cuff plethysmography 0 average of 3-4 consistent readings 12451 266
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 222.0 mmHg 3.7 16.55 tail cuff plethysmography 0 average of 3-4 consistent readings 12453 266
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 209.0 mmHg 3.26 14.58 tail cuff plethysmography 0 average of 3-4 consistent readings 12457 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 308.0 g 1.68 7.51 body weighing method 0 12489 266
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 arterial blood pressure trait male 68 days-98 days 16 177.0 mmHg 5.0 20.0 radiotelemetry 30 0 11970 226
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 310.0 g 2.38 body weighing method 0 11976 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.35 g/kg 0.07 0.3 post excision weight measurement 0 11988 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.11 g/kg 0.04 0.19 post excision weight measurement 0 11992 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.16 g/kg 0.04 0.17 post excision weight measurement 0 11996 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.08 g/kg 0.04 0.17 post excision weight measurement 0 11998 221
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. heart mass male 68 days-70 days 20 1.22 g 0.02 0.08 post excision weight measurement 0 11797 147
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. arterial blood pressure trait male 68 days-70 days 20 serial mean 230.6 mmHg 4.7 21.02 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11807 147
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. heart mass male 68 days-70 days 20 1.25 g 0.02 0.09 post excision weight measurement 0 11809 147
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. heart mass male 68 days-70 days 20 1.24 g 0.01 0.07 post excision weight measurement 0 11821 147
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 4.28 g/kg 0.03 0.13 post excision weight measurement 0 0 12217 232
SS/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 20 304.7 g 2.1 9.39 body weighing method 0 12299 237
SS/Jr both kidneys wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. kidney mass male 70 days-72 days 40 3.08 g 0.04 0.23 post excision weight measurement 0 12312 237
SS/Jr heart wet weight controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. heart mass male 84 days 12 1.22 g 0.02 0.07 post excision weight measurement 0 0 12346 246
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 arterial blood pressure trait male 64 days-66 days 0 204.0 mmHg 3.72 tail cuff plethysmography 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 11911 205
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 1.36 g 0.01 post excision weight measurement 0 12010 205
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 25 and 28 days) Deng AY, et al., Hypertension 1997 Aug;30(2 Pt 1):199-202 arterial blood pressure trait male 65 days-68 days 24 205.8 mmHg 3.91 19.16 tail cuff photoplethysmography tail 0 average of 4 days, 3 to 4 consistent readings each day, IITC 12093 231
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 arterial blood pressure trait male 64 days-68 days 20 204.0 mmHg 2.84 12.7 tail cuff plethysmography tail 345600 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 12127 232
SS/Jr body weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 body mass male 64 days-68 days 20 340.0 g 5.26 23.52 body weighing method 0 0 12141 232
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.25 g 0.01 0.04 digital scale post excision weight measurement 0 0 12671 282
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 33 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 73 days-75 days 10 211.0 mmHg 2.05 6.48 radiotelemetry 345600 0 C-40 transmitter (Data Sciences International, St. Paul, MN) aveerage of 4-hour interval averages over 4 days 12915 313
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 33 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 73 days-75 days 10 162.0 mmHg 1.67 5.28 radiotelemetry 345600 0 C-40 transmitter (Data Sciences International, St. Paul, MN) aveerage of 4-hour interval averages over 4 days 12920 313
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 316.0 g 3.93 17.58 body weighing method 0 12942 305
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 20 1.3 g 0.01 0.05 post excision weight measurement 0 12960 305
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 20 4.44 g/kg 0.09 0.41 post excision weight measurement 0 12991 305
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 18 170.0 mmHg 4.0 16.97 intra-aortic abdominal radiotelemetry 0 12354 242
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 30 3.98 g/kg 0.03 0.16 post excision weight measurement 0 0 12886 313
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.21 g 0.02 0.1 post excision weight measurement 0 regression of heart weight on body weight 12515 266
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.25 g 0.02 0.07 post excision weight measurement 0 12517 266
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.29 g 0.04 0.19 post excision weight measurement 0.0 0 regression of heart weight on body weight 12521 266
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.1 g 0.02 0.08 post excision weight measurement 0 regression of heart weight on body weight 12523 266
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 10 175.0 mmHg 4.0 12.65 intra-aortic abdominal radiotelemetry aorta 0 12544 269
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 4.21 g/kg 0.06 0.27 post excision weight measurement 0 12547 266
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 253.0 mg/d 20.37 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67586 749
SS/Jr calculated heart weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 19 regression of heart weight on body weight 1.2 g 0.01 0.06 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64768 222
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait not specified 64 days-71 days 46 serial mean 207.0 mmHg 2.2 14.92 tail cuff plethysmography tail 0 0 64733 222
SS/Jr heart wet weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 40 1.24 g 0.01 0.05 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64747 222
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. body mass male 40 days-42 days 20 161.0 g 2.1 9.39 body weighing method 0 0 65024 283
SS/Jr heart left ventricle posterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle posterior wall thickness male 77 days 40 0.19 mm 0.0 0.02 transthoracic echocardiography 0 0 65115 542
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 0 and 672 hours) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart mass male 114 days-118 days 4 4.76 g/kg 0.46 0.92 post excision weight measurement 0 0 65133 283
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 50.61 % 5.29 18.33 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69069 1096
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then phenylephrine (1-100 mmol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 104.06 % 4.7 16.28 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69052 1096
SS/Jr heart left ventricle anterior wall thickness controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle anterior wall thickness male 77 days 40 0.19 mm 0.0 0.02 transthoracic echocardiography 0.0 0 68250 542
SS/Jr change in heart rate to change in mean arterial blood pressure ratio sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 -1.6 beats/min/mmHg 0.2 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion average slope, bpm/mm Hg 69749 344
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. arterial blood pressure trait male 68 days-98 days 10 170.0 mmHg radiotelemetry 0.0 0 69025 1096
SS/Jr heart left ventricle fractional shortening controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle end-diastolic diameter male 77 days 40 (LVDdLVDs)/LVDd x 100 50.7 % 0.83 5.25 transthoracic echocardiography 0.0 0 68282 542
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 12 days) Chauvet C, et al., J Hypertens. 2011 Jul;29(7):1320-6. doi: 10.1097/HJH.0b013e32834705e4. arterial blood pressure trait male 68 days 16 serial mean 184.0 mmHg 4.0 16.0 radiotelemetry abdominal aorta 1036800.0 0 telemetry probe averaged over 12 days has records that will be duplicated if entered need to add multiple refs once the functionality is in 96566 1663
SS/Jr heart weight to body weight ratio controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart mass not specified 84 days 5 4.18 g/kg 0.3 0.68 post excision weight measurement 0.0 0 103145 2787
SS/Jr left ventricular end-diastolic blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 3.0 mmHg 0.45 1.0 vascular transducer tipped catheter 0.0 0 103151 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 336.0 beats/min 5.37 12.0 intra-aortic thoracic radiotelemetry 0.0 0 103159 2787
SS/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.4 hours) then ambient air (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 122.0 breaths/min 1.79 4.0 spirometry 0.0 0 103179 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.6 hours) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 4 sampling once per minute 438.0 beats/min 7.0 14.0 intra-aortic thoracic radiotelemetry 0.0 5 min 103190 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.9 hours) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 4 sampling once per minute 428.0 beats/min 6.0 12.0 intra-aortic thoracic radiotelemetry 0.0 25 min 103192 2787
SS/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.9 and 1.3 hours) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 4 sampling once per minute 471.0 beats/min 7.5 15.0 intra-aortic thoracic radiotelemetry 0.0 25 min 103196 2787
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 4 sampling once per minute 135.0 mmHg 1.5 3.0 intra-aortic thoracic radiotelemetry 0.0 0 103200 2787
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 6 serial mean 203.0 mmHg 4.17 10.21 radiotelemetry 0.0 0 97984 1958
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 3 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 10 mean of 3 samples of undefined duration between 7am and 12pm serial mean 140.0 mmHg 2.7 8.54 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102294 2661
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 17 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 10 mean of 3 samples of undefined duration between 7am and 12pm serial mean 164.0 mmHg 4.9 15.5 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102302 2661
SS/Jr tibia midshaft endosteal cross-sectional area controlled sodium chloride content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 3.02 mm2 0.09 micro-computed tomography 0.0 0 98013 1958
SS/Jr heart rate controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. heart pumping trait male 68 days-70 days 6 serial mean 394.0 beats/min 5.97 14.62 radiotelemetry 0.0 0 98193 1958
SS/Jr pulse pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 6 serial mean 53.4 mmHg 1.9 4.65 radiotelemetry 0.0 0 98195 1958
SS/Jr bone section trabecular separation controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. cancellous bone morphology trait male 66 days-70 days 0 0.5 mm 0.07 micro-computed tomography 0.0 0 98119 1958
SS/Jr tibia midshaft cortical thickness controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 0.54 mm 0.02 micro-computed tomography 0.0 0 cortical thickness 98123 1958
SS/Jr systolic blood pressure controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 10 189.0 mmHg 6.0 23.24 vascular transducer tipped catheter 0.0 0 103249 2802
SS/Jr plasma total cholesterol level controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. blood cholesterol amount male 63 days 15 79.15 mg/dl 4.63 17.94 plasma total cholesterol measurement test 0.0 0 103264 2802
SS/Jr bone section total volume controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 44.08 mm3 0.97 micro-computed tomography 0.0 0 total volume 98017 1958
SS/Jr heart weight to body weight ratio controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. heart mass male 63 days 15 2.59 g/kg 0.04 0.15 post excision weight measurement 0.0 0 103240 2802
SS/Jr heart rate controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. heart pumping trait male 68 days-70 days 7 serial mean 395.0 beats/min 6.21 16.43 radiotelemetry 0.0 0 97978 1958
SS/Jr maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 LVdP/dtmax/P 73.0 /s 4.47 13.0 vascular transducer tipped catheter 0.0 0 maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio 106815 2787
SS/Jr bumetanide-sensitive red blood cell Na+ export rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 15 84.0 umol/l/h 65.0 251.74 Na-K-Cl cotransport activity assay 0.0 0 111039 2802
SS/Jr ouabain- and bumetanide-resistant red blood cell Na+ import rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 10 5466.0 umol/l/h 525.0 1660.2 Na+ passive permeability assay 0.0 0 111044 2802
SS/Jr bumetanide-sensitive red blood cell K+ import rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 10 1145.0 umol/l/h 166.0 524.94 Na-K-Cl cotransport activity assay 0.0 0 111052 2802
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 arterial blood pressure trait male 64 days-68 days 20 210.0 mmHg 4.6 20.57 tail cuff plethysmography tail 345600 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 12130 232
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. heart mass male 70 days-72 days 40 1.17 g 0.02 0.11 post excision weight measurement 0 12257 237
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 5.82 g/kg 0.42 post excision weight measurement 0.0 0 67568 749
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 42 days) Palijan A, et al., Physiol Genomics 2003 Sep 29;15(1):1-8. arterial blood pressure trait male 66 days-77 days 15 measurement taken every 4 hours during a 24-hour period serial mean 203.0 mmHg 4.0 15.49 radiotelemetry 86400.0 0 65536 615
SS/Jr heart right ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart right ventricle mass male 98 days 16 0.69 mg/g 0.02 0.08 post excision weight measurement 0 0 64893 226
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 9 and 10 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 76 days-78 days 5 217.9 mmHg 2.1 4.7 intra-aortic abdominal radiotelemetry 86400 0 65044 283
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 41 serial mean 204.7 mmHg 2.1 13.45 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65795 237
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 arterial blood pressure trait male 64 days-66 days 0 198.0 mmHg 3.62 tail cuff plethysmography 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 11912 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 4.04 g/kg 0.03 0.13 post excision weight measurement 0 0 12883 313
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 3.95 g/kg 0.03 0.13 post excision weight measurement 0 0 12885 313
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 25 and 28 days) Dukhanina OI, et al., Mamm Genome 1997 Apr;8(4):229-35. arterial blood pressure trait not specified 64 days-68 days 18 serial mean 217.0 mmHg 4.0 16.97 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11831 148
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 25 and 28 days) Dukhanina OI, et al., Mamm Genome 1997 Apr;8(4):229-35. heart mass not specified 64 days-68 days 18 4.3 g/kg 0.06 0.25 post excision weight measurement 0 11834 148
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 185.0 mmHg 1.97 4.41 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13026 305
SS/Jr heart left ventricle end-diastolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left ventricle end-diastolic diameter male 77 days 40 7.18 mm 0.09 0.57 transthoracic echocardiography 0.0 0 68266 542
SS/Jr aorta smooth muscle cell count per unit vessel length controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. blood vessel smooth muscle cell quantity male 98 days 10 90.0 /um 4.0 12.65 ex vivo light microscopy with digital image analysis 0.0 0 /um - calculated aortic smooth muscle cell count 69034 1096
SS/Jr heart ventricle septal wall thickness controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart left ventricle wall thickness not specified 0 days 6 0.26 cm 0.02 0.05 echocardiography 0.0 0 69606 749
SS/Jr body weight control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 body mass male 84 days-85 days 6 384.0 g 8.9 21.8 body weighing method 0 0 65442 104
SS/Jr heart weight to body weight ratio controlled sodium content diet (1 %) (for 60 days) then controlled sodium content diet (0.2 %) (for 40 days) Zhang QY, et al., Mamm Genome 1997 Sep;8(9):636-41 heart mass male 134 days 21 3.68 g/kg post excision weight measurement 0 0 65965 650
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 7 serial mean 154.0 mmHg 1.59 4.21 radiotelemetry 0.0 0 97986 1958
SS/Jr pulse pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 6 serial mean 53.4 mmHg 1.9 4.65 radiotelemetry 0.0 0 97994 1958
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 10 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 11 mean of 3 samples of undefined duration between 7am and 12pm serial mean 160.0 mmHg 2.7 8.95 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102299 2661
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 199.0 mmHg 5.0 14.14 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65493 611
SS/Jr diastolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 147.0 mmHg 5.5 15.56 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65494 611
SS/Jr systolic blood pressure controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. arterial blood pressure trait male 64 days-72 days 40 serial mean 218.3 mmHg 2.6 16.44 tail cuff plethysmography 345600 0 Rats warmed to 28 degrees C for measurement. 65791 237
SS/Jr urine albumin excretion rate controlled sodium content diet (0.2 %) Poyan Mehr A, et al., Physiol Genomics 2003 Aug 15;14(3):209-16. urine albumin amount not specified 98 days 6 253.07 mg/d enzyme linked immunosorbent assay urine 0.0 0 rat albumin ELISA 13278 335
SS/Jr plasma potassium level controlled sodium content diet (8 %) (between 8 and 10 days) Huang BS, et al., Hypertension. 2007 Apr 9;. blood potassium amount male 43 days-52 days 12 5.1 mmol/l 0.3 1.04 potassium ion-selective electrode method 0 potassium ion-selective electrode 13326 344
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 17 and 18 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 42 days-60 days 15 173.5 mmHg 4.0 15.49 tail cuff photoplethysmography 172800 0 12664 283
SS/Jr heart left ventricle weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 heart left ventricle mass male 98 days 16 3.41 mg/g 0.09 0.36 post excision weight measurement 0 0 64892 226
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 39 and 40 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 107 days-109 days 3 228.2 mmHg 2.6 4.5 intra-aortic abdominal radiotelemetry 86400 0 65047 283
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 17 and 18 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 85 days-87 days 19 257.2 mmHg 5.1 22.23 tail cuff photoplethysmography 172800 0 65072 283
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 31 and 38 days) Ariyarajah A, et al., J Hypertens 2004 Aug;22(8):1495-502. arterial blood pressure trait male 66 days-74 days 16 172.0 mmHg 4.0 16.0 radiotelemetry 0 0 65472 589
SS/Jr heart left ventricle fractional shortening controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 29 days) then controlled sodium content diet (4 %) (between 40 and 41 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart left ventricle end-diastolic diameter male 109 days-112 days 6 44.0 % 4.0 9.8 transthoracic echocardiography 0 0 65749 283
SS/Jr body weight controlled sodium content diet (4 %) (for 28 days) Garrett MR, et al., Physiol Genomics 2000 Jun 29;3(1):33-8. body mass male 53 days-81 days 10 344.0 g 5.1 16.13 body weighing method 0 0 66109 691
SS/Jr systolic blood pressure controlled sodium content diet Garrett MR, et al., Physiol Genomics 2000 Jun 29;3(1):33-8. arterial blood pressure trait male 53 days 10 151.0 mmHg 5.1 16.13 tail cuff plethysmography 0 0 66115 691
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 64 days-66 days 20 195.0 mmHg 3.27 14.62 tail cuff plethysmography 4 0 semi- automatic equipment from IITC, Woodland Hills, CA average of 2-3 readings/day over 4 days 12807 313
SS/Jr diastolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 130.0 mmHg 1.57 3.51 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13031 305
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 36 days) Moujahidine M, et al., Mamm Genome 2002 Mar;13(3):153-6. arterial blood pressure trait male 56 days-71 days 11 serial mean 184.0 mmHg 5.0 16.58 intra-aortic abdominal radiotelemetry aorta 0 0 average of 6 measurements taken every 4 hrs 13078 328
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 20 serial mean 215.0 mmHg 3.72 16.64 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13084 282
SS/Jr heart wet weight controlled sodium content diet (0.2 %) (for 7 days) then controlled sodium content diet (2 %) (for 28 days) Cicila GT, et al., Mamm Genome 1999 Feb;10(2):112-6. heart mass male 65 days 20 1.29 g 0.02 0.08 post excision weight measurement 0 11777 145
SS/Jr systolic blood pressure controlled sodium content diet (1 %) (for 30 days) then controlled sodium content diet (0.2 %) (for 40 days) Cicila GT, et al., Mamm Genome 1997 Dec;8(12):896-902. arterial blood pressure trait male 100 days 21 serial mean 244.0 mmHg 6.2 28.41 tail cuff plethysmography 0 11781 146
SS/Jr body weight controlled sodium content diet (1 %) (for 30 days) then controlled sodium content diet (0.2 %) (for 40 days) Cicila GT, et al., Mamm Genome 1997 Dec;8(12):896-902. body mass male 100 days 21 350.0 g 7.3 33.45 body weighing method 0 11785 146
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 7 days) then controlled sodium content diet (2 %) (for 24 days) Cicila GT, et al., Mamm Genome 1997 Dec;8(12):896-902. arterial blood pressure trait male 61 days 20 serial mean 199.3 mmHg 7.5 33.54 tail cuff plethysmography 0 11787 146
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. heart mass male 68 days-70 days 20 1.28 g 0.02 0.07 post excision weight measurement 0 11803 147
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 20 297.1 g 2.3 10.29 body weighing method 0 11811 147
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 25 and 28 days) Dukhanina OI, et al., Mamm Genome 1997 Apr;8(4):229-35. heart mass not specified 64 days-68 days 20 3.95 g/kg 0.05 0.22 post excision weight measurement 0 11839 148
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 1.26 g 0.03 0.13 digital scale post excision weight measurement 0 0 12669 282
SS/Jr heart rate controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 33 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart pumping trait male 73 days-75 days 10 serial mean 407.0 beats/min 4.0 12.65 radiotelemetry 345600 0 C-40 transmitter (Data Sciences International, St. Paul, MN) aveerage of 4-hour interval averages over 4 days 12925 313
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 311.0 g 1.63 7.29 body weighing method 0 12944 305
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 3 1.48 g 0.07 0.12 post excision weight measurement 0 12961 305
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 20 1.4 g 0.03 0.12 post excision weight measurement 0 12966 305
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 20 4.17 g/kg 0.06 0.28 post excision weight measurement 0 12974 305
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 16 4.18 g/kg 0.07 0.27 post excision weight measurement 0 12987 305
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 64 days-70 days 20 serial mean 213.0 mmHg 4.63 20.71 tail cuff photoplethysmography tail 345600 0 28 degrees C average of 3 averaged readings per day over 4 days 13013 305
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 1.31 g 0.01 post excision weight measurement 0 11982 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.26 g/kg 0.07 0.3 post excision weight measurement 0 11989 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 4.27 g/kg 0.05 post excision weight measurement 0 12048 205
SS/Jr body weight controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 body mass male 98 days 16 348.0 g 9.0 36.0 body weighing method 0 0 12079 226
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Deng AY, et al., Hypertension 1997 Aug;30(2 Pt 1):199-202 heart mass male 68 days 24 3.8 g/kg 0.05 0.23 post excision weight measurement 0 12084 231
SS/Jr body weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 body mass male 64 days-68 days 20 307.0 g 2.02 9.03 body weighing method 0 0 12145 232
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 1.17 g 0.01 0.04 post excision weight measurement 0 0 12157 232
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 heart mass male 64 days-68 days 20 3.83 g/kg 0.04 0.18 post excision weight measurement 0 0 12218 232
SS/Jr body weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Lee SJ, et al., Genetics 2006 Dec;174(4):2203-13. body mass male 70 days-72 days 20 301.8 g 2.4 10.73 body weighing method 0 12296 237
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 arterial blood pressure trait male 64 days-66 days 0 221.0 mmHg 3.95 tail cuff plethysmography 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 11913 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.16 g/kg 0.05 0.21 post excision weight measurement 0 11914 221
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 20 320.0 g 1.52 6.8 whole body digital scale 0 0 12691 282
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.27 g/kg 0.05 0.24 post excision weight measurement 0 12700 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 3.85 g/kg 0.05 0.21 digital scale post excision weight measurement 0 0 12712 282
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 1.2 g 0.01 0.03 post excision weight measurement 0 0 12844 313
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. body mass male 64 days-66 days 20 314.0 g 2.23 9.97 body weighing method 0.0 0 12863 313
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 1.29 g 0.02 0.08 post excision weight measurement 0 regression of heart weight on body weight 12522 266
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.83 g/kg 0.04 0.17 post excision weight measurement 0 12543 266
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 3.99 g/kg 0.04 0.19 post excision weight measurement 0 12546 266
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. heart mass male 68 days-70 days 20 4.0 g/kg 0.04 0.17 post excision weight measurement 0 12549 266
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 221.0 mmHg 3.44 15.38 tail cuff plethysmography 0 average of 3-4 consistent readings 12454 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 294.0 g 4.02 17.98 body weighing method 0 12483 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 318.0 g 3.57 15.97 body weighing method 0 12484 266
SS/Jr mean arterial blood pressure control condition Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. arterial blood pressure trait male 63 days-66 days 8 serial mean 122.0 mmHg radiotelemetry femoral artery 0 connected to solid-state transducer (Argon Medical Technologies, Athens, TX) 5 hr recording session - 1 min. averages 12622 272
SS/Jr calculated heart weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 heart mass not specified 64 days-71 days 40 regression of heart weight on body weight 1.18 g 0.01 0.06 post excision weight measurement 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64766 222
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 200.0 mmHg 4.22 tail cuff plethysmography 0.0 0 67521 749
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. arterial blood pressure trait not specified 65 days-70 days 0 213.0 mmHg 5.14 tail cuff plethysmography 0.0 0 67524 749
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. body mass not specified 0 days 0 307.0 g 4.93 body weighing method 0.0 0 67527 749
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. body mass not specified 0 days 0 312.0 g 2.8 body weighing method 0.0 0 67529 749
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 25 and 28 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. body mass not specified 0 days 0 296.0 g 14.72 body weighing method 0.0 0 67533 749
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 1.28 g 0.02 post excision weight measurement 0.0 0 67543 749
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart mass not specified 0 days 0 4.36 g/kg 0.07 post excision weight measurement 0.0 0 67572 749
SS/Jr serum albumin level controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. blood albumin amount male 84 days 8 2.9 g/dl 0.06 0.17 automated blood analysis 0 0 64820 246
SS/Jr body weight control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 body mass male 56 days-57 days 6 293.0 g 9.8 24.0 body weighing method 0 0 65440 104
SS/Jr artery wall thickness to artery total diameter ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. coronary artery integrity trait male 114 days-118 days 3 54.0 % 7.0 12.12 ex vivo light microscopy 0 0 65738 283
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 0 and 672 hours) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart mass male 114 days-118 days 4 1.67 g 0.07 0.14 post excision weight measurement 0 0 65129 283
SS/Jr heart left atrium end-diastolic diameter controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 35 days) Deng AY, et al., J Hypertens. 2008 Oct;26(10):1935-1943. heart left atrium diameter male 77 days 40 3.43 mm 0.08 0.52 transthoracic echocardiography 0.0 0 68307 542
SS/Jr blood vessel contractile force measurement Kreb's solution perfusate then potassium chloride solution (40 mmol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 1.39 g 0.06 0.21 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69050 1096
SS/Jr age at time of death controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 66 and 68 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total life span not specified 0 days 8 median 108.0 d necropsy 0.0 0 visual observation 69608 749
SS/Jr absolute change in heart rate sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 45.0 beats/min 3.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69737 344
SS/Jr body weight controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. body mass not specified 84 days 5 332.0 g 22.36 50.0 body weighing method 0.0 0 103141 2787
SS/Jr left ventricular systolic blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 180.0 mmHg 4.47 10.0 vascular transducer tipped catheter 0.0 0 103149 2787
SS/Jr mean arterial blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 8 serial mean 175.0 mmHg 6.8 19.23 radiotelemetry 0.0 0 97990 1958
SS/Jr pulse pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 7 serial mean 59.3 mmHg 0.55 1.46 radiotelemetry 0.0 0 97992 1958
SS/Jr pulse pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 8 serial mean 50.4 mmHg 2.35 6.65 radiotelemetry 0.0 0 97993 1958
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 20 serial mean 195.0 mmHg 4.72 21.11 tail cuff volume pressure recording 0.0 0 97985 1958
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 20 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 11 mean of 3 samples of undefined duration between 7am and 12pm serial mean 180.0 mmHg 5.7 18.9 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102307 2661
SS/Jr tibia midshaft total cross-sectional area controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 8.32 mm2 0.08 micro-computed tomography 0.0 0 98011 1958
SS/Jr diastolic blood pressure controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 15 108.0 mmHg 3.0 11.62 vascular transducer tipped catheter 0.0 0 103256 2802
SS/Jr plasma triglyceride level controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. blood triglyceride amount male 63 days 10 1.49 mmol/l 0.29 0.92 plasma triglyceride analysis 0.0 0 103261 2802
SS/Jr bone section surface density controlled sodium content diet (2 %) (between 38 and 42 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. tibia morphology trait male 66 days-70 days 0 1007.94 mg/cm3 5.03 micro-computed tomography 0.0 0 mg HA/ccm 98016 1958
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 0 hours) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 10 mean of 3 samples of undefined duration between 7am and 12pm serial mean 139.0 mmHg 2.7 8.54 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102290 2661
SS/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 0 hours) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 11 mean of 3 samples of undefined duration between 7am and 12pm serial mean 139.0 mmHg 1.4 4.64 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102291 2661
SS/Jr body weight controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. body mass male 63 days 15 271.0 g 10.0 38.73 body weighing method 0.0 0 103236 2802
SS/Jr heart rate controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 28 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. heart pumping trait male 68 days-70 days 6 serial mean 394.0 beats/min 5.97 14.62 radiotelemetry 0.0 0 97980 1958
SS/Jr heart rate controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. heart pumping trait male 68 days-70 days 6 serial mean 394.0 beats/min 5.97 14.62 radiotelemetry 0.0 0 97981 1958
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 8 serial mean 152.0 mmHg 6.49 18.36 radiotelemetry 0.0 0 97987 1958
SS/Jr minimum rate of positive change in left ventricular blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 LVdP/dtmin 7.6 10E3 mmHg/s 4.47 1.3 vascular transducer tipped catheter 0.0 0 minimum rate of positive change in left ventricular blood pressure 106817 2787
SS/Jr artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.21 mm2 0.02 0.06 ex vivo light microscopy with digital image analysis 0.0 0 110461 3107
SS/Jr ouabain- and bumetanide-resistant red blood cell K+ import rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 10 499.0 umol/l/h 33.0 104.36 Na+ passive permeability assay 0.0 0 111056 2802
SS/Jr urine total protein excretion rate controlled sodium content diet (2 %) (between 30 and 33 days) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. total urine protein amount not specified 78 days-83 days 0 78.0 mg/d 13.86 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 67578 749
SS/Jr heart left ventricle relative wall thickness controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 29 days) then controlled sodium content diet (4 %) (between 40 and 41 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. heart left ventricle wall thickness male 109 days-112 days 4 (SWT+PWT)/LVDd 67.0 % 1.0 2.0 transthoracic echocardiography 0 0 65758 283
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (for 24 days) Rapp JP, et al., Genomics 1998 Jul 15;51(2):191-6 arterial blood pressure trait male 62 days 20 195.0 mmHg 2.7 12.07 tail cuff plethysmography 0 0 only mentioned blood pressure 65829 633
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Mamm Genome. 2008 Jan 4 arterial blood pressure trait male 64 days-68 days 20 209.0 mmHg 3.51 15.7 tail cuff plethysmography tail 345600 0 warm up to 28 C Average of 3-4 consistent measurements taken each day over 4 consecutive days 12128 232
SS/Jr body weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass not specified 64 days-71 days 19 299.0 g 4.0 17.44 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64727 222
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.26 g/kg 0.03 0.14 post excision weight measurement 0 11931 221
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 4.26 g/kg 0.16 0.73 digital scale post excision weight measurement 0 0 12709 282
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 44 3.88 g/kg 0.03 0.19 digital scale post excision weight measurement 0 0 12711 282
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 20 serial mean 242.0 mmHg 3.7 16.55 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13082 282
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 20 serial mean 191.0 mmHg 1.58 7.07 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13085 282
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 1.25 g 0.01 0.04 post excision weight measurement 0.0 0 12843 313
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. heart mass male 64 days-66 days 20 1.35 g 0.01 0.04 post excision weight measurement 0 0 12845 313
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 6 4.04 g/kg 0.08 0.2 post excision weight measurement 0 12989 305
SS/Jr absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 43 days-51 days 0 17.0 mmHg 2.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 68138 344
SS/Jr absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 13.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 68142 344
SS/Jr heart left ventricle relative wall thickness controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) Kumarasamy S, et al., Hypertens Res. 2011 Dec;34(12):1263-70. doi: 10.1038/hr.2011.116. Epub 2011 Aug 4. heart left ventricle wall thickness not specified 0 days 6 107.0 % 34.0 83.28 echocardiography 0.0 0 69611 749
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait not specified 64 days-71 days 40 serial mean 216.0 mmHg 2.4 15.18 tail cuff plethysmography tail 0 0 64736 222
SS/Jr both kidneys wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. kidney mass male 114 days-118 days 4 4.17 g 0.14 0.28 post excision weight measurement 0 0 65122 283
SS/Jr heart rate controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 28 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. heart pumping trait male 68 days-70 days 8 serial mean 397.0 beats/min 9.01 25.48 radiotelemetry 0.0 0 97979 1958
SS/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 135.0 mmHg 0.89 2.0 intra-aortic thoracic radiotelemetry 0.0 0 103165 2787
SS/Jr mean arterial blood pressure controlled sodium content diet (0.3 %) (for 12 days) then controlled sodium content diet (2 %) (for 24 days) Nie Y, et al., Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. arterial blood pressure trait male 68 days-70 days 6 serial mean 175.0 mmHg 3.75 9.19 radiotelemetry 0.0 0 98194 1958
SS/Jr single kidney wet weight to body weight ratio controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. kidney mass male 63 days 10 8.65 g/kg 0.17 0.54 post excision weight measurement 0.0 0 103245 2802
SS/Jr plasma glucose level controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 48 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. blood glucose amount male 114 days-118 days 4 142.2 mg/dl 19.8 39.6 blood glucose analysis 0 0 65092 283
SS/Jr heart wet weight controlled sodium content diet (0.4 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., Hum Mol Genet. 2009 Aug 1;18(15):2825-38. Epub 2009 May 7. heart mass male 64 days-70 days 20 serial mean 1.32 g 0.01 0.06 post excision weight measurement 345600 0 65314 565
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 79 and 80 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 147 days-149 days 1 219.7 mmHg 1.7 1.7 intra-aortic abdominal radiotelemetry 86400 0 65053 283
SS/Jr body weight controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass not specified 64 days-71 days 46 302.0 g 1.8 12.21 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64713 222
SS/Jr both kidneys wet weight to body weight ratio controlled sodium content diet (2 %) (between 35 and 98 days) Duong C, et al., Mamm Genome 2006; 17(12): 1147-1161 kidney mass male 98 days 16 12.1 g/kg 0.3 1.2 post excision weight measurement 0 0 64772 226
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 24 days) Rapp JP, et al., Genomics 1998 Jul 15;51(2):191-6 heart mass male 62 days 20 1.36 g 0.01 0.06 post excision weight measurement 0 0 65834 633
SS/Jr systolic blood pressure controlled sodium content diet (4 %) (for 14 days) Garrett MR, et al., Physiol Genomics 2000 Jun 29;3(1):33-8. arterial blood pressure trait male 67 days 10 218.0 mmHg 7.8 24.67 tail cuff plethysmography 0 0 66117 691
SS/Jr body weight gain controlled sodium content diet (8 %) (between 8 and 10 days) Huang BS, et al., Hypertension. 2007 Apr 9;. body mass male 43 days-52 days 12 51.0 g 2.0 6.93 body weighing method 0 13318 344
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 26 and 27 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 42 days-69 days 15 181.9 mmHg 4.1 15.88 tail cuff photoplethysmography 172800 0 12665 283
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 64 days-70 days 16 serial mean 205.0 mmHg 4.91 19.64 tail cuff photoplethysmography tail 345600 0 28 degrees C average of 3 averaged readings per day over 4 days 13015 305
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 210.0 mmHg 3.3 14.76 tail cuff plethysmography 0 0 average of 4days 65479 611
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 191.0 mmHg 3.5 15.65 tail cuff plethysmography 0 0 average of 4days 65481 611
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 63 days-70 days 20 202.0 mmHg 4.1 18.34 tail cuff plethysmography 0 0 average of 4days 65483 611
SS/Jr systolic blood pressure control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 arterial blood pressure trait male 84 days-85 days 6 serial mean 182.0 mmHg 4.1 10.04 tail cuff plethysmography tail 2 days between 7 am and 12 pm 0 11588 104
SS/Jr systolic blood pressure control condition Garrett MR, et al., J Am Soc Nephrol 2003 May;14(5):1175-87 arterial blood pressure trait male 140 days-141 days 6 serial mean 193.0 mmHg 10.5 25.72 tail cuff plethysmography tail 2 days between 7 am and 12 pm 0 11592 104
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. arterial blood pressure trait male 64 days-70 days 20 serial mean 189.0 mmHg 2.92 13.06 tail cuff photoplethysmography tail 345600 0 average of 4 daily averages of 3-4 measurements/day 13117 282
SS/Jr urine albumin excretion rate controlled sodium content diet (0.2 %) Poyan Mehr A, et al., Physiol Genomics 2003 Aug 15;14(3):209-16. urine albumin amount not specified 196 days 12 148.47 mg/d enzyme linked immunosorbent assay urine 0.0 0 rat albumin ELISA 13283 335
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 218.0 mmHg 3.83 17.13 tail cuff plethysmography 0 average of 3-4 consistent readings 12455 266
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 235.0 mmHg 4.8 21.47 tail cuff plethysmography 0 average of 3-4 consistent readings 12456 266
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. arterial blood pressure trait male 64 days-70 days 20 191.0 mmHg 3.48 15.56 tail cuff plethysmography 0 average of 3-4 consistent readings 12459 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 309.0 g 3.43 15.34 body weighing method 0 12485 266
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Physiol Genomics 2001 Jan 19;4(3):201-14. body mass male 68 days-70 days 20 304.0 g 2.6 11.63 body weighing method 0.0 0 12510 266
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 16 184.0 mmHg 4.0 16.0 intra-aortic abdominal radiotelemetry aorta 0 12595 269
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 7 days) then controlled sodium content diet (2 %) (for 42 days) Cicila GT, et al., Mamm Genome 1997 Dec;8(12):896-902. arterial blood pressure trait male 79 days 20 serial mean 231.4 mmHg 7.2 32.2 tail cuff plethysmography 0 11789 146
SS/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 7 days) then controlled sodium content diet (4 %) (for 24 days) Cicila GT, et al., Mamm Genome 1997 Dec;8(12):896-902. arterial blood pressure trait male 61 days 22 serial mean 264.0 mmHg 5.5 25.8 tail cuff plethysmography 0 11791 146
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 20 298.2 g 4.2 18.78 body weighing method 0 11799 147
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. arterial blood pressure trait male 68 days-70 days 20 serial mean 235.1 mmHg 4.6 20.57 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11813 147
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. heart mass male 68 days-70 days 20 1.27 g 0.03 0.13 post excision weight measurement 0 11815 147
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. arterial blood pressure trait male 68 days-70 days 20 serial mean 232.7 mmHg 3.2 14.31 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11819 147
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 24 and 27 days) Cicila GT, et al., Genomics 2001 Feb 15;72(1):51-60. body mass male 68 days-70 days 19 302.3 g 3.5 15.26 body weighing method 0 11829 147
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 25 and 28 days) Dukhanina OI, et al., Mamm Genome 1997 Apr;8(4):229-35. arterial blood pressure trait not specified 64 days-68 days 20 serial mean 205.0 mmHg 2.9 12.97 tail cuff plethysmography 0 average of 12 readings from 4 daily sessions 11837 148
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 10 170.0 mmHg 5.0 15.81 intra-aortic abdominal radiotelemetry 0 12322 242
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.05 g/kg 0.03 0.15 post excision weight measurement 0 11932 221
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. body mass male 68 days-70 days 44 314.0 g 2.0 13.27 whole body digital scale 0 0 12692 282
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 20 3.9 g/kg 0.02 0.11 digital scale post excision weight measurement 0 0 12710 282
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 331.0 g 2.08 body weighing method 0 11975 205
SS/Jr body weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 body mass male 64 days-66 days 0 337.0 g 2.36 body weighing method 0 11973 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (2 %) (between 24 and 27 days) Garrett MR, et al., Hypertension 2001 Oct;38(4):779-85 heart mass male 64 days-69 days 20 4.22 g/kg 0.06 0.29 post excision weight measurement 0 11993 221
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) Saad Y, et al., Genomics. 2007 Mar;89(3):343-53. Epub 2007 Jan 10. heart mass male 68 days-70 days 30 1.25 g 0.01 0.07 digital scale post excision weight measurement 0 0 12677 282
SS/Jr pulse pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 33 days) Toland EJ, et al., Mamm Genome. 2008 Mar;19(3):209-18. Epub 2008 Mar 7. arterial blood pressure trait male 73 days-75 days 10 58.0 mmHg 0.38 1.2 radiotelemetry 345600 0 C-40 transmitter (Data Sciences International, St. Paul, MN) aveerage of 4-hour interval averages over 4 days 12922 313
SS/Jr body weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. body mass male 68 days-70 days 20 316.0 g 2.83 12.66 body weighing method 0 12950 305
SS/Jr heart wet weight controlled sodium content diet (2 %) (for 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart mass male 68 days-70 days 6 1.39 g 0.03 0.08 post excision weight measurement 0 12964 305
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 24 and 28 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 64 days-70 days 20 serial mean 213.0 mmHg 4.85 21.69 tail cuff photoplethysmography tail 345600 0 28 degrees C average of 3 averaged readings per day over 4 days 13011 305
SS/Jr serum triglyceride level controlled sodium content diet (0.3 %) Packard M, et al., Am J Physiol Renal Physiol. 2009 Apr;296(4):F839-46. Epub 2009 Jan 28. blood triglyceride amount male 28 days-84 days 8 66.0 mg/dl 4.1 11.6 automated blood analysis 0 12399 246
SS/Jr heart wet weight controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 1.26 g 0.01 post excision weight measurement 0 12007 205
SS/Jr heart weight to body weight ratio controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 24 days) Saad Y, et al., Hypertension. 2007 heart mass male 64 days-66 days 0 3.9 g/kg 0.04 post excision weight measurement 0