Phenominer Database Results (254 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
Crl:SD brain campesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. brain campesterol amount not specified 77 days 2 0.02 mg/g unspecified method 0.0 0 tissue campesterol measurement test 70528 1300
Crl:SD liver campesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. liver campesterol amount not specified 77 days 2 0.03 mg/g unspecified method 0.0 0 tissue campesterol measurement test 70520 1300
Crl:SD blood glucose level controlled fructose content drinking water (5 %) (for 63 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 63 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood glucose amount female 98 days 12 81.0 mg/dl 2.34 8.1 blood glucose analysis 0.0 0 week one 75793 1538
Crl:SD blood glucose level controlled fructose content drinking water (5 %) (for 63 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 63 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood glucose amount female 98 days 12 79.2 mg/dl 1.87 6.48 blood glucose analysis 0.0 0 week one 75794 1538
Crl:SD liver cholesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. liver cholesterol amount not specified 77 days 2 1.72 mg/g unspecified method 0.0 0 tissue total cholesterol analysis 70163 1300
Crl:SD plasma insulin level controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 63 days-77 days 9 51.0 mU/l 7.0 21.0 radioimmunoassay 0.0 0 F 75847 1540
Crl:SD plasma glucose level controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 63 days-77 days 9 117.0 mg/dl 3.6 10.8 liquid phase colorimetry 0.0 0 F 75855 1540
Crl:SD water drink intake rate control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. drinking behavior trait male 63 days-77 days 8 43.0 ml/d 1.7 4.81 unspecified method 0.0 0 C 75864 1540
Crl:SD metformin drink intake rate controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. drinking behavior trait male 63 days-77 days 10 35.0 ml/d 0.4 1.26 unspecified method 0.0 0 metformin drink intake rate 75865 1540
Crl:SD body weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 175.1 g 2.37 8.2 body weighing method 0.0 0 week one 75756 1538
Crl:SD body weight controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 171.7 g 2.08 7.2 body weighing method 0.0 0 week one 75753 1538
Crl:SD total body fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. adipose amount female 105 days 12 28.9 cm3 1.5 5.2 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75815 1538
Crl:SD blood glucose level controlled ethanol content drinking water (1 %) (for 63 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood glucose amount female 98 days 12 82.8 mg/dl 4.1 14.22 blood glucose analysis 0.0 0 week one 75791 1538
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days 12 19.8 g/d unspecified method 0.0 0 week one 75744 1538
Crl:SD body weight controlled ethanol content drinking water (1 %) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days 12 92.6 g 3.03 10.5 body weighing method 0.0 0 week one 75747 1538
Crl:SD body weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 173.7 g 2.86 9.9 body weighing method 0.0 0 week one 75754 1538
Crl:SD plasma total cholesterol level controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood cholesterol amount female 105 days 12 115.83 mg/dl 1.89 6.56 plasma total cholesterol measurement test 0.0 0 week one 75781 1538
Crl:SD plasma total cholesterol level controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood cholesterol amount female 105 days 11 119.69 mg/dl 2.33 7.72 plasma total cholesterol measurement test 0.0 0 week one 75784 1538
Crl:SD food calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 23.5 kcal/d unspecified method 0.0 0 food energy intake 76108 1538
Crl:SD liver weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 5.6 g 0.25 0.86 post excision weight measurement 0.0 0 liver weight 75773 1538
Crl:SD plasma triglyceride level controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood triglyceride amount female 105 days 12 1.3 mmol/l 0.1 0.36 plasma triglyceride analysis 0.0 0 week one 75787 1538
Crl:SD plasma triglyceride level controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood triglyceride amount female 105 days 11 1.7 mmol/l 0.24 0.79 plasma triglyceride analysis 0.0 0 week one 75789 1538
Crl:SD body weight controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 149.1 g 1.7 5.9 magnetic resonance imaging 0.0 0 week one 75797 1538
Crl:SD body weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 153.1 g 2.31 8.0 magnetic resonance imaging 0.0 0 week one 75800 1538
Crl:SD kidney glomerulus volume control condition Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 2.36 x 10E6 um3 0.24 0.59 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 100788 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 158.33 null 4.59 11.24 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100789 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 178.53 null 22.47 55.04 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100790 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 179.66 null 2.47 6.05 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100791 2522
Crl:SD water intake drink rate to body weight ratio arterial catheter implantation (for 1 days) Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. drinking behavior trait male 89 days-95 days 11 0.49 ml/d/kg 0.05 0.17 drink intake measuring method 0.0 arterial catheter implantation 1 days Water consumed (g) postsurgery per 100 g BW 107165 3077
Crl:SD plasma albumin level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood albumin amount male 91 days-154 days 0 25.8 g/l 0.4 automated plasma albumin analysis 0 plasma albumin level 106831 3067
Crl:SD systolic blood pressure controlled protein content diet (20 %) then water (for 120 days) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. arterial blood pressure trait male 540 days-660 days 9 168.0 mmHg 6.0 18.0 tail cuff plethysmography tail 0.0 0 108593 3126
Crl:SD plasma alanine aminotransferase activity level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood alanine transaminase amount female 91 days-154 days 0 41.0 U/l 4.32 automated plasma alanine aminotransferase activity assay 0 automated plasma alanine aminotransferase activity assay (MMO:0000808) plasma ALT 106880 3067
Crl:SD plasma globulin level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood globulin amount male 91 days-154 days 0 31.16 g/l 0.54 automated plasma globulin analysis 0 automated plasma globulin analysis (MMO:0000806) plasma globulin 106835 3067
Crl:SD plasma urea nitrogen level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood urea nitrogen amount male 91 days-154 days 0 6.01 mmol/l 0.56 automated plasma urea analysis 0 plasma urea nitrogen 106839 3067
Crl:SD plasma urea nitrogen level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood urea nitrogen amount female 91 days-154 days 0 5.21 mmol/l 0.43 automated plasma urea analysis 0 plasma urea nitrogen 106840 3067
Crl:SD plasma glucose level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood glucose amount male 91 days-154 days 0 180.0 mg/dl 7.56 automated plasma glucose analysis 0 plasma glucose 106859 3067
Crl:SD plasma calcium level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood calcium amount female 91 days-154 days 0 2.38 mmol/l 0.04 automated plasma calcium test 0.0 0 automated plasma calcium test (MMO:0000804) plasma calcium 110149 3067
Crl:SD food intake rate controlled ethanol content drinking water (1 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 10.2 g/d unspecified method 0.0 0 week one 75737 1538
Crl:SD plasma campesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. blood campesterol amount not specified 77 days 2 1.3 mg/dl unspecified method 0.0 0 plasma campesterol measurement test 70515 1300
Crl:SD total body fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. adipose amount female 105 days 12 29.6 cm3 1.41 4.9 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75814 1538
Crl:SD whole body subcutaneous fat volume controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. subcutaneous adipose amount female 105 days 12 14.4 ml 0.58 2.0 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75817 1538
Crl:SD ethanol drink intake rate controlled ethanol content drinking water (1 %) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days 12 11.6 g/d unspecified method 0.0 0 week one 75721 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (for 7 days) and controlled ethanol content drinking water (1 %) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days 12 10.1 g/d unspecified method 0.0 0 week one 75718 1538
Crl:SD fructose drink calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 5.6 kcal/d unspecified method 0.0 0 fructose energy intake 76102 1538
Crl:SD left renal fat pad weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.77 g 0.04 0.14 post excision weight measurement 0.0 0 total body fat volume, cm3 75839 1538
Crl:SD left renal fat pad weight to body weight ratio controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.43 % 0.02 0.08 post excision weight measurement 0.0 0 total body fat volume, cm3 75842 1538
Crl:SD plasma insulin level control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 63 days-77 days 8 33.0 mU/l 2.0 5.66 radioimmunoassay 0.0 0 C 75848 1540
Crl:SD plasma insulin level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 63 days-77 days 10 32.0 mU/l 4.0 12.65 radioimmunoassay 0.0 0 FT 75849 1540
Crl:SD plasma insulin level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 63 days-77 days 8 26.0 mU/l 2.0 5.66 radioimmunoassay 0.0 0 CT 75850 1540
Crl:SD plasma glucose level control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 63 days-77 days 8 111.6 mg/dl 1.8 5.09 liquid phase colorimetry 0.0 0 C 75856 1540
Crl:SD plasma glucose level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 63 days-77 days 10 111.6 mg/dl 1.8 5.69 liquid phase colorimetry 0.0 0 FT 75857 1540
Crl:SD plasma glucose level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 63 days-77 days 8 111.6 mg/dl 5.4 15.27 liquid phase colorimetry 0.0 0 CT 75858 1540
Crl:SD plasma glucose level controlled fructose content diet (66 %) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 42 days 9 108.0 mg/dl 1.8 5.4 liquid phase colorimetry 0.0 0 F 75859 1540
Crl:SD plasma glucose level controlled metformin content drinking water (350-500 mg/kg/d) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 42 days 8 106.2 mg/dl 9.0 25.46 liquid phase colorimetry 0.0 0 CT 75862 1540
Crl:SD food intake rate controlled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days 12 9.6 g/d unspecified method 0.0 0 week one 75720 1538
Crl:SD body weight controlled fructose content drinking water (5 %) and controlled ethanol content drinking water (1 %) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days 12 87.8 g 3.93 13.6 body weighing method 0.0 0 week one 75748 1538
Crl:SD liver weight to body weight ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 32.0 g/kg 0.98 3.4 post excision weight measurement 0.0 0 week one 75779 1538
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 105 days 12 29.4 g/d unspecified method 0.0 0 week one 75745 1538
Crl:SD whole body subcutaneous fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. subcutaneous adipose amount female 105 days 12 15.4 ml 0.81 2.8 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75818 1538
Crl:SD whole body visceral fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. visceral adipose mass female 105 days 12 13.9 ml 0.69 2.4 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75824 1538
Crl:SD whole body lean tissue volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body lean mass female 105 days 12 96.1 cm3 1.88 6.5 magnetic resonance imaging 0.0 0 whole body lean tissue volume cm3 75831 1538
Crl:SD blood glucose level controlled fructose content drinking water (5 %) (for 63 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 63 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood glucose amount female 98 days 12 81.0 mg/dl 2.75 9.54 blood glucose analysis 0.0 0 week one 75795 1538
Crl:SD plasma insulin level controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 0 days 0 53.0 mU/l 7.0 radioimmunoassay 0.0 0 F 75879 1540
Crl:SD fructose drink intake rate controlled fructose content drinking water (5 %) (for 7 days) and controlled ethanol content drinking water (1 %) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days 12 20.8 g/d unspecified method 0.0 0 week one 75722 1538
Crl:SD food intake rate controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 105 days 12 10.0 g/d unspecified method 0.0 0 week one 75733 1538
Crl:SD plasma triglyceride level controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood triglyceride amount female 105 days 12 1.7 mmol/l 0.18 0.62 plasma triglyceride analysis 0.0 0 week one 75788 1538
Crl:SD plasma total cholesterol level controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood cholesterol amount female 105 days 12 127.41 mg/dl 2.23 7.72 plasma total cholesterol measurement test 0.0 0 week one 75785 1538
Crl:SD body weight gain controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days-105 days 12 88.3 g 2.22 7.7 body weighing method 0.0 0 week one 75759 1538
Crl:SD food intake rate controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. eating behavior trait male 63 days-77 days 9 26.0 g/d 1.7 5.1 unspecified method 0.0 0 F 75871 1540
Crl:SD food intake rate control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. eating behavior trait male 63 days-77 days 8 28.0 g/d 0.9 2.55 unspecified method 0.0 0 C 75872 1540
Crl:SD food intake rate controlled metformin content drinking water (350-500 mg/kg/d) then controlled fructose content diet (66 %) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. eating behavior trait male 42 days 10 18.0 g/d 0.3 0.95 unspecified method 0.0 0 FT 75877 1540
Crl:SD body weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 151.5 g 2.66 9.2 magnetic resonance imaging 0.0 0 week one 75798 1538
Crl:SD serum aspartate aminotransferase activity level control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. blood aspartate transaminase amount male 63 days 5 61.8 U/l 1.32 2.95 automated serum analysis 0.0 0 105049 3010
Crl:SD systolic blood pressure controlled protein content diet (20 %) then perindopril (1 mg/kg/d) (for 120 days) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. arterial blood pressure trait male 540 days-660 days 8 130.0 mmHg 7.0 19.8 tail cuff plethysmography tail 0.0 0 108594 3126
Crl:SD urine total protein excretion rate controlled protein content diet (20 %) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. total urine protein amount male 420 days-540 days 8 61.0 mg/d 11.0 31.11 Bradford protein assay 0.0 0 108598 3126
Crl:SD plasma gamma-glutamyltransferase activity level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood gamma-glutamyltransferase amount female 91 days-154 days 0 0.0 U/l 0.0 automated plasma gamma-glutamyltransferase activity assay 0 automated plasma gamma-glutamyltransferase activity assay (MMO:0000831) plasma GGT activity 106864 3067
Crl:SD plasma alkaline phosphatase activity level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood alkaline phosphatase amount male 91 days-154 days 0 279.8 IU/l 45.35 automated plasma alkaline phosphatase activity assay 0 plasma AP 106875 3067
Crl:SD plasma sodium level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood sodium amount female 91 days-154 days 0 141.8 mmol/l 0.58 automated plasma sodium test 0 plasma sodium 106852 3067
Crl:SD plasma potassium level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood potassium amount female 91 days-154 days 0 3.74 mmol/l 0.08 automated plasma potassium test 0 plasma potassium 106856 3067
Crl:SD plasma glucose level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood glucose amount female 91 days-154 days 0 160.02 mg/dl 4.32 automated plasma glucose analysis 0 plasma glucose 106860 3067
Crl:SD volume of blood removed to total prehemorrhagic blood volume ratio arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0.4 hours) Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. blood amount male 89 days-95 days 11 5.83 mL/100 g of body weight 56.8 % 0.2 0.66 body weighing method 0 volume of blood removed to total prehemorrhagic blood volume ratio (CMO:0003663) 109134 3077
Crl:SD body weight controlled fructose content drinking water (5 %) and controlled bisphenol A content drinking water (0.25 mg/l) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days 12 88.7 g 2.97 10.3 body weighing method 0.0 0 week one 75750 1538
Crl:SD whole body subcutaneous fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. subcutaneous adipose amount female 105 days 12 15.1 ml 0.84 2.9 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75820 1538
Crl:SD whole body visceral fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. visceral adipose mass female 105 days 12 14.3 ml 0.87 3.0 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75823 1538
Crl:SD brain cholesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. brain cholesterol amount not specified 77 days 2 10.95 mg/g unspecified method 0.0 0 tissue lipid analysis 70524 1300
Crl:SD liver phytosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. liver phytosterol amount not specified 77 days 2 0.05 mg/g unspecified method 0.0 0 tissue lipid analysis 70550 1300
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 105 days 12 36.8 g/d unspecified method 0.0 0 week one 75728 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 8.5 g/d unspecified method 0.0 0 week one 75739 1538
Crl:SD food intake rate controlled fructose content diet (66 %) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. eating behavior trait male 42 days 9 19.0 g/d 0.3 0.9 unspecified method 0.0 0 F 75875 1540
Crl:SD food intake rate controlled metformin content drinking water (350-500 mg/kg/d) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. eating behavior trait male 42 days 8 17.0 g/d 0.2 0.57 unspecified method 0.0 0 CT 75878 1540
Crl:SD serum creatinine level control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. blood creatinine amount male 63 days 5 0.23 mg/dl 0.0 0.01 automated serum analysis 0.0 0 105061 3010
Crl:SD kidney glomerulus volume control condition Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 364 days 5 2.36 x 10E6 um3 0.16 0.36 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 100775 2522
Crl:SD plasma sitosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. blood sitosterol amount not specified 77 days 2 1.95 mg/dl unspecified method 0.0 0 70532 1300
Crl:SD liver sitosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. liver sitosterol amount not specified 77 days 2 0.03 mg/g unspecified method 0.0 0 tissue lipid analysis 70537 1300
Crl:SD plasma phytosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. blood phytosterol amount not specified 77 days 2 3.3 mg/dl unspecified method 0.0 0 70545 1300
Crl:SD liver fat volume to total liver volume ratio controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver adipose amount female 105 days 12 5.5 % 0.29 1.0 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75832 1538
Crl:SD liver fat volume to total liver volume ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver adipose amount female 105 days 11 5.6 % 0.26 0.86 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75833 1538
Crl:SD left renal fat pad weight controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.86 g 0.06 0.21 post excision weight measurement 0.0 0 total body fat volume, cm3 75838 1538
Crl:SD left renal fat pad weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.76 g 0.04 0.14 post excision weight measurement 0.0 0 total body fat volume, cm3 75840 1538
Crl:SD left renal fat pad weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.88 g 0.07 0.25 post excision weight measurement 0.0 0 total body fat volume, cm3 75841 1538
Crl:SD left renal fat pad weight to body weight ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.44 % 0.02 0.08 post excision weight measurement 0.0 0 total body fat volume, cm3 75845 1538
Crl:SD systolic blood pressure controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. arterial blood pressure trait male 63 days-77 days 10 143.0 mmHg 2.0 6.32 tail cuff plethysmography tail 0.0 0 FT 75853 1540
Crl:SD plasma glucose level control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 42 days 8 118.8 mg/dl 5.4 15.27 liquid phase colorimetry 0.0 0 C 75860 1540
Crl:SD metformin drink intake rate controlled metformin content drinking water (350-500 mg/kg/d) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. drinking behavior trait male 42 days 8 31.0 ml/d 0.3 0.85 unspecified method 0.0 0 metformin drink intake rate 75870 1540
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 28.1 g/d unspecified method 0.0 0 week one 75731 1538
Crl:SD whole body lean tissue volume controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body lean mass female 105 days 12 95.5 cm3 0.84 2.9 magnetic resonance imaging 0.0 0 whole body lean tissue volume cm3 75827 1538
Crl:SD whole body lean tissue volume controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body lean mass female 105 days 12 95.2 cm3 1.24 4.3 magnetic resonance imaging 0.0 0 whole body lean tissue volume cm3 75828 1538
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 105 days 12 33.0 g/d unspecified method 0.0 0 week one 75727 1538
Crl:SD plasma glucagon level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucagon amount male 0 days 8 353.0 pmol/l 27.0 76.37 radioimmunoassay 0.0 0 FT 75923 1540
Crl:SD plasma glucagon level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) then insulin (2 U/kg/d) (for 14 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucagon amount male 0 days 8 402.0 pmol/l 32.0 90.51 radioimmunoassay 0.0 0 FT 75924 1540
Crl:SD systolic blood pressure controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. arterial blood pressure trait male 0 days 0 160.0 mmHg 3.0 tail cuff plethysmography tail 0.0 0 F 75925 1540
Crl:SD systolic blood pressure controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) then insulin (2 U/kg/d) (for 14 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. arterial blood pressure trait male 0 days 8 158.0 mmHg 3.0 8.49 tail cuff plethysmography tail 0.0 0 FT 75926 1540
Crl:SD total calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. consumption behavior trait female 42 days-105 days 12 29.5 kcal/d unspecified method 0.0 0 total energy intake 76114 1538
Crl:SD plasma insulin level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) then insulin (2 U/kg/d) (for 14 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 0 days 8 68.0 mU/l 3.0 8.49 radioimmunoassay 0.0 0 FT 75880 1540
Crl:SD liver weight to body weight ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 32.0 g/kg 0.92 3.2 post excision weight measurement 0.0 0 week one 75778 1538
Crl:SD plasma triglyceride level controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood triglyceride amount female 105 days 12 1.6 mmol/l 0.24 0.83 plasma triglyceride analysis 0.0 0 week one 75790 1538
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 364 days 6 3.14 x 10E6 um3 0.19 0.47 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100772 2522
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 364 days 6 2.18 x 10E6 um3 0.11 0.27 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100773 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 364 days 6 182.12 null 13.44 32.92 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100777 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 308 days) then enalapril (15 mg/l) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 364 days 6 201.08 null 15.0 36.74 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100778 2522
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) and anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 2.37 x 10E6 um3 0.15 0.37 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100787 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) and anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 201.84 null 11.34 27.78 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100792 2522
Crl:SD serum alanine aminotransferase activity level control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. blood alanine transaminase amount male 63 days 5 54.8 U/l 0.97 2.17 automated serum analysis 0.0 0 105051 3010
Crl:SD serum glucose level control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. blood glucose amount male 63 days 5 132.6 mg/dl 2.52 5.64 automated serum analysis 0.0 0 105065 3010
Crl:SD mean arterial blood pressure arterial catheter implantation (for 1 days) Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. arterial blood pressure trait male 89 days-95 days 11 115.0 mmHg 3.0 9.95 vascular fluid filled catheter 300.0 0 5-second intervals Initial MAP 107340 3077
Crl:SD food intake weight to body weight ratio arterial catheter implantation (for 1 days) Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. eating behavior trait male 89 days-95 days 11 5.5 g/d/100g 0.3 0.99 food intake measuring method 0.0 arterial catheter implantation 1 days Food consumed (g) postsurgery per 100 g BW 107149 3077
Crl:SD hematocrit arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0 hours) Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. erythrocyte quantity male 89 days-95 days 11 40.9 % 0.9 2.98 microhematocrit tube assay with visual assessment 0.0 0 initial hematocrit, final hematocrit, change in hematocrit 107244 3077
Crl:SD urine total protein excretion rate controlled protein content diet (20 %) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. total urine protein amount male 420 days-540 days 9 54.0 mg/d 5.0 15.0 Bradford protein assay 0.0 0 108595 3126
Crl:SD plasma alkaline phosphatase activity level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood alkaline phosphatase amount female 91 days-154 days 0 160.4 IU/l 30.09 automated plasma alkaline phosphatase activity assay 0 plasma AP 106876 3067
Crl:SD plasma alanine aminotransferase activity level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood alanine transaminase amount male 91 days-154 days 0 51.16 U/l 5.41 automated plasma alanine aminotransferase activity assay 0 automated plasma alanine aminotransferase activity assay (MMO:0000808) plasma ALT 106879 3067
Crl:SD plasma globulin level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood globulin amount female 91 days-154 days 0 31.8 g/l 0.4 automated plasma globulin analysis 0 automated plasma globulin analysis (MMO:0000806) plasma globulin 106836 3067
Crl:SD plasma triglyceride level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood triglyceride amount female 91 days-154 days 0 0.77 mmol/l 0.09 automated plasma triglyceride analysis 0 plasma triglyceride 106844 3067
Crl:SD plasma total cholesterol level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood cholesterol amount male 91 days-154 days 0 66.8 mg/dl 8.49 automated plasma total cholesterol analysis 0 plasma total cholesterol 106847 3067
Crl:SD plasma total cholesterol level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood cholesterol amount female 91 days-154 days 0 71.04 mg/dl 6.18 automated plasma total cholesterol analysis 0 plasma total cholesterol 106848 3067
Crl:SD body weight gain controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days-105 days 12 86.4 g 4.01 13.9 body weighing method 0.0 0 week one 75761 1538
Crl:SD brain sitosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. brain sitosterol amount not specified 77 days 2 0.02 mg/g unspecified method 0.0 0 tissue lipid analysis 70541 1300
Crl:SD plasma glucose level controlled metformin content drinking water (350-500 mg/kg/d) then controlled fructose content diet (66 %) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 42 days 10 104.4 mg/dl 9.0 28.46 liquid phase colorimetry 0.0 0 FT 75861 1540
Crl:SD water drink intake rate control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. drinking behavior trait male 42 days 8 35.0 ml/d 0.7 1.98 unspecified method 0.0 0 C 75868 1540
Crl:SD food intake rate controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 105 days 12 7.9 g/d unspecified method 0.0 0 week one 75735 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 8.7 g/d unspecified method 0.0 0 week one 75741 1538
Crl:SD both kidneys wet weight to body weight ratio control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. kidney mass male 63 days 5 0.1 g/kg 0.0 0.0 post excision weight measurement 0.0 0 105047 3010
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 30.1 g/d unspecified method 0.0 0 week one 75732 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 105 days 12 8.3 g/d unspecified method 0.0 0 week one 75743 1538
Crl:SD body weight controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 11 172.3 g 1.63 5.4 body weighing method 0.0 0 week one 75752 1538
Crl:SD plasma phosphate level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood phosphate amount female 91 days-154 days 0 6.17 mg/dl 0.32 automated plasma phosphate test 0 automated plasma phosphate analysis (MMO:0000795) plasma PO 110145 3067
Crl:SD food calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 24.6 kcal/d unspecified method 0.0 0 food energy intake 76109 1538
Crl:SD number of podocytes per kidney glomerulus control condition Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 364 days 5 212.59 null 11.41 25.51 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 100779 2522
Crl:SD brain phytosterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. brain phytosterol amount not specified 77 days 2 0.03 mg/g unspecified method 0.0 0 tissue lipid analysis 70554 1300
Crl:SD liver fat volume to total liver volume ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver adipose amount female 105 days 12 6.9 % 0.21 0.73 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75836 1538
Crl:SD left renal fat pad weight controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.74 g 0.04 0.15 post excision weight measurement 0.0 0 total body fat volume, cm3 75837 1538
Crl:SD left renal fat pad weight to body weight ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.5 % 0.04 0.13 post excision weight measurement 0.0 0 total body fat volume, cm3 75846 1538
Crl:SD systolic blood pressure control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. arterial blood pressure trait male 63 days-77 days 8 141.0 mmHg 2.0 5.66 tail cuff plethysmography tail 0.0 0 C 75852 1540
Crl:SD metformin drink intake rate controlled metformin content drinking water (350-500 mg/kg/d) then controlled fructose content diet (66 %) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. drinking behavior trait male 42 days 10 33.0 ml/d 0.6 1.9 unspecified method 0.0 0 metformin drink intake rate 75869 1540
Crl:SD food intake rate controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 105 days 12 8.3 g/d unspecified method 0.0 0 week one 75734 1538
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days 12 20.4 g/d unspecified method 0.0 0 week one 75723 1538
Crl:SD body weight gain controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days-105 days 12 82.6 g 2.57 8.9 body weighing method 0.0 0 week one 75760 1538
Crl:SD liver weight controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 5.1 g 0.06 0.2 post excision weight measurement 0.0 0 liver weight 75772 1538
Crl:SD liver weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 5.6 g 0.2 0.68 post excision weight measurement 0.0 0 liver weight 75774 1538
Crl:SD ethanol drink intake rate controlled ethanol content drinking water (1 %) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 11.5 g/d unspecified method 0.0 0 week one 75729 1538
Crl:SD whole body subcutaneous fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. subcutaneous adipose amount female 105 days 12 15.6 ml 0.75 2.6 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75819 1538
Crl:SD whole body visceral fat volume controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. visceral adipose mass female 105 days 12 13.9 ml 0.43 1.5 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75822 1538
Crl:SD whole body visceral fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. visceral adipose mass female 105 days 12 13.8 ml 0.75 2.6 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75825 1538
Crl:SD total body fat volume controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. adipose amount female 105 days 12 28.2 cm3 0.98 3.4 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75812 1538
Crl:SD total body fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. adipose amount female 105 days 12 31.7 cm3 1.44 5.0 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75816 1538
Crl:SD food calorie intake rate controlled ethanol content drinking water (1 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 28.9 kcal/d unspecified method 0.0 0 food energy intake 76105 1538
Crl:SD food calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled ethanol content drinking water (1 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 24.6 kcal/d unspecified method 0.0 0 food energy intake 76106 1538
Crl:SD total calorie intake rate controlled ethanol content drinking water (1 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. consumption behavior trait female 42 days-105 days 12 28.9 kcal/d unspecified method 0.0 0 total energy intake 76110 1538
Crl:SD total calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. consumption behavior trait female 42 days-105 days 12 29.7 kcal/d unspecified method 0.0 0 total energy intake 76112 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 105 days 12 7.8 g/d unspecified method 0.0 0 week one 75736 1538
Crl:SD ethanol drink intake rate controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 105 days 12 10.8 g/d unspecified method 0.0 0 week one 75725 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 8.3 g/d unspecified method 0.0 0 week one 75740 1538
Crl:SD liver weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 5.4 g 0.12 0.43 post excision weight measurement 0.0 0 liver weight 75775 1538
Crl:SD liver weight to body weight ratio controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 28.0 g/kg 0.46 1.6 post excision weight measurement 0.0 0 week one 75776 1538
Crl:SD liver weight to body weight ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 31.0 g/kg 0.49 1.7 post excision weight measurement 0.0 0 week one 75780 1538
Crl:SD blood glucose level controlled fructose content drinking water (5 %) (for 63 days) and controlled ethanol content drinking water (1 %) (for 63 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood glucose amount female 98 days 12 84.6 mg/dl 3.64 12.6 blood glucose analysis 0.0 0 week one 75792 1538
Crl:SD food intake rate controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. eating behavior trait male 63 days-77 days 8 24.0 g/d 0.1 0.28 unspecified method 0.0 0 CT 75874 1540
Crl:SD body weight controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 148.4 g 1.36 4.7 magnetic resonance imaging 0.0 0 week one 75796 1538
Crl:SD body weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 149.6 g 2.74 9.5 magnetic resonance imaging 0.0 0 week one 75799 1538
Crl:SD plasma glucose level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 0 days 8 102.6 mg/dl 3.6 10.18 liquid phase colorimetry 0.0 0 FT 75921 1540
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 2.4 x 10E6 um3 0.11 0.27 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100786 2522
Crl:SD number of podocytes per kidney glomerulus control condition Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 212.59 null 18.05 44.21 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 100793 2522
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 308 days) then enalapril (15 mg/l) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 364 days 6 2.06 x 10E6 um3 0.14 0.34 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100774 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 364 days 6 158.59 null 4.58 11.22 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100776 2522
Crl:SD liver weight to body weight ratio control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. liver mass male 63 days 5 0.46 g/kg 0.01 0.03 post excision weight measurement 0.0 0 105045 3010
Crl:SD body weight control condition Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. body mass male 88 days-94 days 11 448.0 g 8.0 26.53 body weighing method 0.0 0 107351 3077
Crl:SD plasma total bilirubin level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood bilirubin amount female 91 days-154 days 0 0.14 mg/dl 0.02 automated plasma total bilirubin analysis 0.0 0 automated plasma total bilirubin analysis (MMO:0000824) total plasma bilirubin 111467 3067
Crl:SD plasma osmolality control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood homeostasis trait male 91 days-154 days 0 284.6 umol/g 0.33 osmometry 0.0 0 calculated plasma osmolality - mmol/kg body weight 111470 3067
Crl:SD urine total protein excretion rate controlled protein content diet (20 %) then water (for 120 days) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. total urine protein amount male 540 days-660 days 9 57.0 mg/d 5.0 15.0 Bradford protein assay 0.0 0 108596 3126
Crl:SD plasma creatinine level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood creatinine amount female 91 days-154 days 0 0.2 mg/dl 0.0 automated plasma creatinine analysis 0 plasma creatinine 106868 3067
Crl:SD plasma chloride level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood chloride amount female 91 days-154 days 0 101.6 mmol/l 0.67 automated plasma chloride test 0 plasma chloride 106872 3067
Crl:SD plasma triglyceride level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood triglyceride amount male 91 days-154 days 0 0.83 mmol/l 0.22 automated plasma triglyceride analysis 0 plasma triglyceride 106843 3067
Crl:SD plasma potassium level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood potassium amount male 91 days-154 days 0 4.33 mmol/l 0.15 automated plasma potassium test 0 plasma potassium 106855 3067
Crl:SD plasma osmolality control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood homeostasis trait female 91 days-154 days 0 284.8 umol/g 1.02 osmometry 0.0 0 calculated plasma osmolality - mmol/kg body weight 111471 3067
Crl:SD whole body lean tissue volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body lean mass female 105 days 12 96.6 cm3 1.44 5.0 magnetic resonance imaging 0.0 0 whole body lean tissue volume cm3 75829 1538
Crl:SD body weight controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 105 days 12 172.9 g 3.41 11.8 body weighing method 0.0 0 week one 75755 1538
Crl:SD liver weight controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 4.8 g 0.08 0.29 post excision weight measurement 0.0 0 week one, liver weight 75771 1538
Crl:SD liver weight to body weight ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver mass female 105 days 12 30.0 g/kg 0.29 1.0 post excision weight measurement 0.0 0 week one 75777 1538
Crl:SD water drink intake rate controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. drinking behavior trait male 63 days-77 days 9 39.0 ml/d 0.7 2.1 unspecified method 0.0 0 F 75863 1540
Crl:SD body weight gain controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days-105 days 12 86.2 g 4.16 14.4 body weighing method 0.0 0 week one 75758 1538
Crl:SD plasma glucose level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) then insulin (2 U/kg/d) (for 14 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucose amount male 0 days 8 82.8 mg/dl 7.2 20.36 liquid phase colorimetry 0.0 0 FT 75922 1540
Crl:SD serum alkaline phosphatase activity level control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. blood alkaline phosphatase amount male 63 days 5 294.2 U/l 28.42 63.55 automated serum analysis 0.0 0 105053 3010
Crl:SD fructose drink calorie intake rate controlled ethanol content drinking water (1 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 0.0 kcal/d unspecified method 0.0 0 76100 1538
Crl:SD fructose drink calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 4.9 kcal/d unspecified method 0.0 0 fructose energy intake 76104 1538
Crl:SD plasma total cholesterol level control condition Yu H, et al., BMC Cardiovasc Disord 2003 Jun 3;3(1):4. blood cholesterol amount not specified 77 days 2 54.6 mg/dl unspecified method 0.0 0 70158 1300
Crl:SD liver fat volume to total liver volume ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver adipose amount female 105 days 12 6.4 % 0.35 1.2 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75834 1538
Crl:SD liver fat volume to total liver volume ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. liver adipose amount female 105 days 12 7.0 % 0.49 1.7 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75835 1538
Crl:SD left renal fat pad weight to body weight ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 11 0.5 % 0.03 0.11 post excision weight measurement 0.0 0 total body fat volume, cm3 75843 1538
Crl:SD left renal fat pad weight to body weight ratio controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. renal fat pad mass female 105 days 12 0.44 % 0.02 0.07 post excision weight measurement 0.0 0 total body fat volume, cm3 75844 1538
Crl:SD systolic blood pressure controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. arterial blood pressure trait male 63 days-77 days 9 159.0 mmHg 2.0 6.0 tail cuff plethysmography tail 0.0 0 F 75851 1540
Crl:SD systolic blood pressure controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. arterial blood pressure trait male 63 days-77 days 8 142.0 mmHg 3.0 8.49 tail cuff plethysmography tail 0.0 0 CT 75854 1540
Crl:SD water drink intake rate controlled fructose content diet (66 %) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. drinking behavior trait male 42 days 9 34.0 ml/d 0.3 0.9 unspecified method 0.0 0 F 75867 1540
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days 12 21.8 g/d unspecified method 0.0 0 week one 75724 1538
Crl:SD body weight controlled fructose content drinking water (5 %) and controlled bisphenol A content drinking water (2.5 mg/l) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days 12 88.3 g 3.38 11.7 body weighing method 0.0 0 week one 75751 1538
Crl:SD food intake rate controlled ethanol content drinking water (1 %) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days 12 10.8 g/d unspecified method 0.0 0 week one 75717 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled ethanol content drinking water (1 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 8.7 g/d unspecified method 0.0 0 week one 75738 1538
Crl:SD bisphenol A in fructose drink intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 24.7 g/d unspecified method 0.0 0 week one 75746 1538
Crl:SD total body fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. adipose amount female 105 days 12 29.8 cm3 1.65 5.7 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75813 1538
Crl:SD whole body subcutaneous fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. subcutaneous adipose amount female 105 days 12 16.4 ml 0.66 2.3 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75821 1538
Crl:SD whole body lean tissue volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body lean mass female 105 days 12 95.4 cm3 1.73 6.0 magnetic resonance imaging 0.0 0 whole body lean tissue volume cm3 75830 1538
Crl:SD fructose drink calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 5.7 kcal/d unspecified method 0.0 0 fructose energy intake 76101 1538
Crl:SD fructose drink calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 6.0 kcal/d unspecified method 0.0 0 fructose energy intake 76103 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days 12 9.3 g/d unspecified method 0.0 0 week one 75742 1538
Crl:SD body weight controlled fructose content drinking water (5 %) and controlled bisphenol A content drinking water (0.025 mg/l) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days 12 84.7 g 3.2 11.1 body weighing method 0.0 0 week one 75749 1538
Crl:SD plasma total cholesterol level controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood cholesterol amount female 105 days 12 119.69 mg/dl 2.56 8.88 plasma total cholesterol measurement test 0.0 0 week one 75782 1538
Crl:SD plasma total cholesterol level controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood cholesterol amount female 105 days 12 123.55 mg/dl 1.78 6.18 plasma total cholesterol measurement test 0.0 0 week one 75783 1538
Crl:SD plasma triglyceride level controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. blood triglyceride amount female 105 days 12 0.88 mmol/l 0.06 0.22 plasma triglyceride analysis 0.0 0 week one 75786 1538
Crl:SD food intake rate control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. eating behavior trait male 42 days 8 18.0 g/d 0.3 0.85 unspecified method 0.0 0 C 75876 1540
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 3.14 x 10E6 um3 0.19 0.47 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100784 2522
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 2.44 x 10E6 um3 0.21 0.51 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100785 2522
Crl:SD serum urea nitrogen level control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. blood urea nitrogen amount male 63 days 5 12.4 mg/dl 0.25 0.55 automated serum analysis 0.0 0 105059 3010
Crl:SD absolute change in hematocrit arterial catheter implantation (for 1 days) then controlled hemorrhage (between 0 and 0.4 hours) Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. erythrocyte quantity male 89 days-95 days 11 11.1 % 1.9 6.3 microhematocrit tube assay with visual assessment 0.0 0 initial hematocrit, final hematocrit, change in hematocrit 107276 3077
Crl:SD plasma albumin level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood albumin amount female 91 days-154 days 0 28.2 g/l 1.3 automated plasma albumin analysis 0 plasma albumin level 106832 3067
Crl:SD urine total protein excretion rate controlled protein content diet (20 %) then perindopril (1 mg/kg/d) (for 120 days) Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. total urine protein amount male 540 days-660 days 8 32.0 mg/d 9.0 25.46 Bradford protein assay 0.0 0 108597 3126
Crl:SD plasma creatinine level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood creatinine amount male 91 days-154 days 0 0.17 mg/dl 0.02 automated plasma creatinine analysis 0 plasma creatinine 106867 3067
Crl:SD plasma chloride level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood chloride amount male 91 days-154 days 0 101.83 mmol/l 0.31 automated plasma chloride test 0 plasma chloride 106871 3067
Crl:SD plasma sodium level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood sodium amount male 91 days-154 days 0 139.6 mmol/l 0.42 automated plasma sodium test 0 plasma sodium 106851 3067
Crl:SD plasma gamma-glutamyltransferase activity level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood gamma-glutamyltransferase amount male 91 days-154 days 0 0.6 U/l 0.33 automated plasma gamma-glutamyltransferase activity assay 0.0 0 automated plasma gamma-glutamyltransferase activity assay (MMO:0000831) plasma GGT activity 106863 3067
Crl:SD maximum body weight loss to initial body weight ratio arterial catheter implantation (for 1 days) Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. body mass male 89 days-95 days 11 3.3 % 0.6 1.99 body weighing method 0.0 arterial catheter implantation 1 days 107186 3077
Crl:SD plasma phosphate level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood phosphate amount male 91 days-154 days 0 7.33 mg/dl 0.28 automated plasma phosphate test 0 automated plasma phosphate analysis (MMO:0000795) plasma PO 110144 3067
Crl:SD plasma calcium level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood calcium amount male 91 days-154 days 0 2.38 mmol/l 0.02 automated plasma calcium test 0 automated plasma calcium test (MMO:0000804) plasma calcium 110148 3067
Crl:SD plasma total bilirubin level control condition Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24. blood bilirubin amount male 91 days-154 days 0 0.13 mg/dl 0.03 automated plasma total bilirubin analysis 0.0 0 automated plasma total bilirubin analysis (MMO:0000824) total plasma bilirubin 111466 3067
Crl:SD whole body visceral fat volume controlled fructose content drinking water (5 %) (for 70 days) and controlled bisphenol A content drinking water (2.5 mg/l) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. visceral adipose mass female 105 days 12 15.3 ml 0.81 2.8 magnetic resonance imaging 0.0 0 total body fat volume, cm3 75826 1538
Crl:SD body weight gain controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. body mass female 35 days-105 days 12 80.1 g 2.6 9.0 body weighing method 0.0 0 week one 75757 1538
Crl:SD fructose drink intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled ethanol content drinking water (1 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 42 days-105 days 12 28.3 g/d unspecified method 0.0 0 week one 75730 1538
Crl:SD metformin drink intake rate controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. drinking behavior trait male 63 days-77 days 8 37.0 ml/d 0.5 1.41 unspecified method 0.0 0 metformin drink intake rate 75866 1540
Crl:SD fructose drink intake rate controlled fructose content drinking water (5 %) (for 70 days) and controlled ethanol content drinking water (1 %) (for 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. drinking behavior trait female 105 days 12 32.0 g/d unspecified method 0.0 0 week one 75726 1538
Crl:SD food intake rate controlled fructose content drinking water (5 %) (for 7 days) and controlled bisphenol A content drinking water (0.025 mg/l) (for 7 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days 12 10.0 g/d unspecified method 0.0 0 week one 75719 1538
Crl:SD food intake rate controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. eating behavior trait male 63 days-77 days 10 24.0 g/d 0.4 1.26 unspecified method 0.0 0 FT 75873 1540
Crl:SD serum total bilirubin level control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. blood bilirubin amount male 63 days 5 0.1 mg/dl 0.0 0.0 automated serum analysis 0.0 0 below lower limit 105055 3010
Crl:SD serum total cholesterol level control condition (for 63 days) Cheng Y, et al., Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. blood cholesterol amount male 63 days 5 89.4 mg/dl 3.33 7.44 automated serum analysis 0.0 0 105063 3010
Crl:SD hematocrit arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0.4 hours) Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. erythrocyte quantity male 89 days-95 days 11 29.8 % 1.8 5.97 microhematocrit tube assay with visual assessment 0.0 0 initial hematocrit, final hematocrit, change in hematocrit 107260 3077
Crl:SD food calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.025 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. eating behavior trait female 42 days-105 days 12 24.1 kcal/d unspecified method 0.0 0 food energy intake 76107 1538
Crl:SD total calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled ethanol content drinking water (1 %) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. consumption behavior trait female 42 days-105 days 12 30.3 kcal/d unspecified method 0.0 0 total energy intake 76111 1538
Crl:SD total calorie intake rate controlled fructose content drinking water (5 %) (between 7 and 70 days) and controlled bisphenol A content drinking water (0.25 mg/l) (between 7 and 70 days) Ronn M, et al., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8. consumption behavior trait female 42 days-105 days 12 29.5 kcal/d unspecified method 0.0 0 total energy intake 76113 1538