Phenominer Database Results (1551 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 107.63 mmHg 5.23 12.82 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 15977 381
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 0.27 ml 0.01 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15461 381
FHH/EurMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 235.44 % 16.66 52.67 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14381 381
FHH/EurMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 228.21 % 20.39 67.63 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14385 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 124.92 mmHg 5.11 16.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15095 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.44 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15322 381
FHH/EurMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 354.94 beats/min 7.82 20.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 15342 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.36 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15286 381
FHH/EurMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 76.05 ml/min 4.5 14.92 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14639 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 113.88 mmHg 7.4 22.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14662 381
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 18.64 mmHg 7.01 9.91 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15762 381
FHH/EurMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 3 -1.13 degrees C 0.17 0.29 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15164 381
FHH/EurMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 31.2 ml/min 2.63 8.72 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15172 381
FHH/EurMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 384.36 beats/min 62.94 109.01 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15196 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 136.55 mmHg 6.41 18.12 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15200 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 7.45 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14597 381
FHH/EurMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 143.63 % 3.58 23.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54086 381
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 7 1.37 mg/d 0.31 0.81 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51465 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 389.31 beats/min 12.58 28.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50877 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 2 23.96 mmHg 20.35 28.78 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50903 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -12.36 beats/min 24.22 54.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51502 481
FHH/EurMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 7 17.36 mg/d 2.63 6.96 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51554 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 8 428.75 beats/min 6.19 17.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51576 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 122.0 mmHg 3.95 8.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51140 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.25 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51320 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 10.7 mmHg 1.87 5.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51345 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -5.36 beats/min 26.01 58.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51348 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 32.74 mmHg 4.09 9.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50748 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 2 27.32 mmHg 13.75 19.45 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50790 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 140.46 mmHg 4.67 12.37 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50795 481
FHH/EurMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.47 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17318 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 159.89 % 9.61 37.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13733 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 0.3 ml 0.01 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13987 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 131.09 % 6.07 19.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14032 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 538.06 beats/min 13.66 30.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14064 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 -0.02 null 0.02 0.04 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13861 381
FHH/EurMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.43 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20024 381
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 10.89 mmHg 0.64 0.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20725 381
FHH/EurMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 56.44 ml/min 2.4 15.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20825 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 -7.42 mmHg 2.68 3.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20081 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 46.57 ml/min 3.14 10.4 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20122 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 5 134.67 mmHg 6.99 15.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19705 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 37.4 mmHg 3.71 7.43 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19837 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 19.65 mmHg 3.47 9.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20868 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18789 381
FHH/EurMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 84.22 breaths/min 3.19 10.59 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18377 381
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 50 76.3 mg/dl 1.7 12.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37160 401
FHH/EurMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 13 5.65 g/dl 0.11 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37221 401
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 18 268.28 U/l 12.37 52.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36431 401
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 50 5.36 g/dl 0.07 0.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37025 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.23 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37066 401
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.42 ml 0.04 0.13 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17002 381
FHH/EurMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 31.58 ml/min 1.47 4.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15613 381
FHH/EurMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 -0.34 degrees C 0.18 0.59 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15639 381
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 8 1.77 ml/min 0.16 0.45 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51803 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 2 8.24 mmHg 7.11 10.05 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51818 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 116.75 mmHg 1.54 4.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51820 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -2.4 beats/min 10.64 23.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51717 481
FHH/EurMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 15 429.33 beats/min 8.27 32.03 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52487 482
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 13.14 ng/ml/h 1.17 2.86 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50567 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 0.56 mmHg 1.17 3.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50599 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -4.12 beats/min 18.68 41.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50612 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -1.4 beats/min 7.97 22.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50622 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 -3.9 mmHg 1.51 3.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50626 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 7 1.61 ml/min 0.15 0.38 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51932 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.27 ml/min 0.15 0.33 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51943 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 39 0.43 mg/dl 0.02 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52264 482
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -65.74 beats/min 24.24 72.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 52057 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 9 11.85 ng/ml/h 0.69 2.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50394 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 9.06 ng/ml/h 1.26 3.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50457 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 358.13 beats/min 16.04 39.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50481 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -24.77 beats/min 14.96 44.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50512 481
FHH/EurMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 91.72 breaths/min 4.84 16.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13660 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 156.95 % 10.95 36.31 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14141 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.02 null 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14745 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 23.38 mmHg 1.18 1.66 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13427 381
FHH/EurMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 239.5 % 13.95 48.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14251 381
FHH/EurMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 %change=VE during7-9 min hypercapnia/control during standard conditions 205.71 % 7.5 49.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14262 381
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 2 115.6 beats/min 48.0 67.88 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51613 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 25.88 mmHg 1.67 2.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51660 481
FHH/EurMcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 15 171.9 g 4.1 15.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17870 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 -50.36 mmHg 4.55 13.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17936 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -50.89 mmHg 2.79 7.89 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17941 381
FHH/EurMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 147.81 breaths/min 4.95 14.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20675 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 33.58 mmHg 1.78 4.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19567 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 10 -8.18 mmHg 0.79 2.51 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19635 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 120.53 mmHg 4.49 12.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17762 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 58.76 ml/min 2.75 8.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18068 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17611 381
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.4 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18634 381
FHH/EurMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 260.9 % 17.85 56.44 stop flow air displacement plethysmography 0 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19047 381
FHH/EurMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.4 degrees C 0.2 0.68 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19122 381
FHH/EurMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 13 260.85 U/l 12.99 46.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37473 401
FHH/EurMcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70 days-84 days 28 0.53 g 0.01 0.06 digital scale post excision weight measurement 0 63770 529
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 19 402.94 beats/min 12.75 55.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17524 381
FHH/EurMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 9.3 mg/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36605 401
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 112.83 breaths/min 6.95 23.04 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18147 381
FHH/EurMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 49 9.68 mg/dl 0.06 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36801 401
FHH/EurMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 58.86 mmHg 5.74 12.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49041 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 65.18 mmHg 5.09 12.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49042 461
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 16 51.87 mmHg 1.3 5.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20496 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 570.99 beats/min 9.14 20.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20527 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20544 381
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 14 6.49 % 2.33 8.7 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49749 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 15 1006.31 s 59.16 229.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49350 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 11.18 % 2.16 6.47 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49636 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 7.84 % 1.8 4.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49641 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 44 92.22 mmHg 2.74 18.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49950 461
FHH/EurMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 13 94.62 U/l 5.32 19.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42440 401
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 16 57.06 fl 0.28 1.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38797 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 16 52.99 % 0.9 3.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39043 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 47 55.55 % 0.52 3.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39054 401
FHH/EurMcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 139.14 mmol/l 0.94 2.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39082 401
FHH/EurMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 48 0.7 x 1000 cells/ul 0.04 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38938 401
FHH/EurMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.76 mmol/l 0.23 0.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42165 401
FHH/EurMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 18.88 mmol/l 1.3 3.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42198 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 50 3.66 g/dl 0.05 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42296 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 49 18.29 pg 0.1 0.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42608 401
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 47 9.69 x 10E6 cells/ul 0.09 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39300 401
FHH/EurMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.86 g/dl 0.06 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39529 401
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 18 96.89 U/l 4.74 20.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42822 401
FHH/EurMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 49 0.22 mg/dl 0.01 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42688 401
FHH/EurMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 153.69 % 5.13 14.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54518 381
FHH/EurMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 13 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42906 401
FHH/EurMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 13 17.71 pg 0.08 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40221 401
FHH/EurMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 158.48 % 4.68 16.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53631 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 118.99 % 5.87 18.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54551 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.41 % 9.21 27.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53554 381
FHH/EurMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 13 5.04 mmol/l 0.51 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43350 401
FHH/EurMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 13 0.14 x 1000 cells/ul 0.02 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40317 401
FHH/EurMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 48 0.19 x 1000 cells/ul 0.02 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40336 401
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 5 0.09 mmHg-1 0.02 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 59009 526
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 18 1.76 g/dl 0.04 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40602 401
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 50 1.7 g/dl 0.05 0.35 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40613 401
FHH/EurMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 5.11 x 1000 cells/ul 0.39 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40641 401
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 49 5.31 x 1000 cells/ul 0.32 2.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40989 401
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 13 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59381 526
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 18 52.56 U/l 3.75 15.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40766 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 4.95 x 1000 cells/ul 0.57 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41145 401
FHH/EurMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 13.75 ml/min/kg 1.22 2.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 59638 526
FHH/EurMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 49 9.13 mg/dl 0.22 1.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37869 401
FHH/EurMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 15.15 g/dl 0.34 0.95 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41622 401
FHH/EurMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 119 0.01 umol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62785 528
FHH/EurMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 17.59 pg 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38391 401
FHH/EurMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 49 93.31 mg/dl 1.38 9.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38475 401
FHH/EurMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 7 7.89 mg/dl 0.19 0.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38232 401
FHH/EurMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70 days-84 days 124 277.48 g 2.34 26.04 whole body digital scale 0 62951 528
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 18 19.89 mmol/l 1.23 5.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38313 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 49 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41710 401
FHH/EurMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 80.33 % 8.26 20.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62629 528
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 320.02 beats/min 37.3 91.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46516 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.34 ml/min/g 1.0 3.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46520 461
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 18 152.78 mg/dl 5.46 23.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38582 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 51 0.13 mg/dl 0.01 0.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41931 401
FHH/EurMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 20 1230.85 s 35.59 159.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46600 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 47.87 % 9.4 24.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47513 461
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 -8.35 null 0.09 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55289 522
FHH/EurMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 -6.76 null 0.06 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55372 522
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 42 post-ischemic value/pre-ischemic value x 100% 78.72 % 2.67 17.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48818 461
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 14.99 mmHg 1.74 2.46 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16256 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 14.92 mmHg 2.44 6.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16271 381
FHH/EurMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 79.21 ml/min 6.44 18.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 16238 381
FHH/EurMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -6.91 null 0.07 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55639 522
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -8.66 mmHg 0.96 2.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16307 381
FHH/EurMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 436.42 beats/min 9.9 28.0 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 16352 381
FHH/EurMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 6 0.62 degrees C 0.26 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 16375 381
FHH/EurMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 6 0.5 degrees C 0.3 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 16380 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 93.61 mmHg 2.25 6.37 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16385 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 3 108.22 mmHg 4.43 7.68 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16420 381
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 58.54 % 1.94 5.14 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Dyets 58202 526
FHH/EurMcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount male 70 days-84 days 159 5.56 g/dl 0.02 0.28 standard blood chemistry panel 0 61272 527
FHH/EurMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 15 37.31 degrees C 0.17 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16865 381
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 0.43 null 0.05 0.18 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58165 526
FHH/EurMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 99.38 % 0.42 1.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55965 522
FHH/EurMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 -8.55 null 0.25 0.6 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56000 522
FHH/EurMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 -8.51 null 0.07 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56016 522
FHH/EurMcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70 days-84 days 25 104.68 mmol/l 0.51 2.54 standard blood chemistry panel 0 62327 527
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.76 null 0.12 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56119 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 54 -7.85 null 0.09 0.65 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56138 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 5 -7.39 null 0.08 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56173 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 5 -7.56 null 0.12 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56176 522
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 54 0.04 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58552 526
FHH/EurMcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70 days-84 days 25 63.04 mg/dl 1.84 9.19 standard blood chemistry panel 0 62399 527
FHH/EurMcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70 days-84 days 25 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 62245 527
FHH/EurMcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70 days-84 days 158 0.05 x 1000 cells/ul 0.01 0.06 automated blood cell counting method 0 62256 527
FHH/EurMcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70 days-84 days 157 3.74 x 1000 cells/ul 0.16 1.95 automated blood cell counting method 0 62102 527
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 20 0.33 null 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58785 526
FHH/EurMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.58 E-7mole 0.24 0.77 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56534 522
FHH/EurMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 5 1.94 g/mg 0.09 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55010 522
FHH/EurMcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70 days-84 days 158 140.35 mmol/l 0.28 3.5 flame atomic emission spectrometry 0 61826 527
FHH/EurMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 0.09 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56812 522
FHH/EurMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 0.74 umol/l 0.12 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56876 522
FHH/EurMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 0.01 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56699 522
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 3 1.09 null 0.12 0.2 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60090 526
FHH/EurMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.23 g/mg 0.11 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56984 522
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 63.83 ml/min 4.33 14.99 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17472 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 10 36.51 mmHg 0.71 2.24 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16070 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 17 35.88 mmHg 0.49 2.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16088 381
FHH/EurMcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 158 17.46 pg 0.04 0.51 automated blood cell counting method 0 60514 527
FHH/EurMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 1.8 E-7mole 0.28 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57130 522
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 50 10.18 ml/min/g 0.32 2.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46715 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 167.6 mmHg 14.06 31.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45868 461
FHH/EurMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 106.18 mmHg 4.55 11.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45945 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 38 post-ischemic value/pre-ischemic value x 100% 53.36 % 4.6 28.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46382 461
FHH/EurMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 72.12 % 5.23 16.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46022 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 113.74 % 29.64 78.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46032 461
FHH/EurMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 114.32 mmHg 7.53 18.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45013 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 60.29 mmHg 2.65 7.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45055 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 48 4.68 ml/min/g 0.24 1.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44780 461
FHH/EurMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 6 56.5 mmHg 3.43 8.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48139 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 43 223.63 beats/min 17.45 114.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45210 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 45 post-ischemic value/pre-ischemic value x 100% 92.48 % 7.69 51.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48357 461
FHH/EurMcwi renal blood flow rate controlled in situ renal perfusion pressure (140 mmHg) Lopez B, et al., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22. renal blood flow trait male 140 days 12 7.95 ml/min/g 0.5 1.73 ultrasonic flowmeter 0.0 0 69369 1156
FHH/EurMcwi blood urea nitrogen level control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. blood urea nitrogen amount male 189 days 7 20.5 mg/dl 3.22 8.52 automated blood analysis 0.0 0 ACE Autoanalyzer Clinical Chemistry System 96905 1738
FHH/EurMcwi liver weight to body weight ratio control condition Westbrook L, et al., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10. liver mass male 168 days 6 35.6 g/kg 0.73 1.79 post excision weight measurement 0.0 0 99469 2318
FHH/EurMcwi water drink intake rate control condition Westbrook L, et al., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10. drinking behavior trait male 168 days 6 20.0 ml/d 5.0 12.25 graduated cylinder 0.0 0 99475 2318
FHH/EurMcwi timed urine volume control condition Westbrook L, et al., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10. urine output male 56 days 6 47.0 ml/d 3.4 8.33 urine volume measurement method 0.0 0 99477 2318
FHH/EurMcwi serum triglyceride level control condition Westbrook L, et al., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10. blood triglyceride amount male 56 days 6 32.0 mg/dl 1.4 3.43 serum triglyceride analysis 0.0 0 99507 2318
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 -0.61 degrees C 0.22 0.82 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20362 381
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 -2.98 mmHg 0.76 2.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50635 481
FHH/EurMcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 53 0.85 g 0.02 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49123 461
FHH/EurMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 160.91 % 16.95 47.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53848 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 109.53 % 2.79 19.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53886 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 29.01 mmHg 2.54 5.09 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 21003 381
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 43.7 mmHg 3.55 7.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50652 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 55.32 mmHg 2.61 6.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50663 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 4.59 mmHg 1.15 2.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50694 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 16.18 mmHg 8.6 21.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50705 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 382.78 beats/min 3.08 9.73 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51586 481
FHH/EurMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.73 degrees C 0.15 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 17568 381
FHH/EurMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 386.16 beats/min 34.85 49.28 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17667 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 145.7 breaths/min 8.4 26.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17684 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 7.43 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14421 381
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 0.89 mEq/d 0.23 0.64 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51050 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 1.21 ml/min 0.21 0.42 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51062 481
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.36 ml 0.01 0.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15326 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 129.17 mmHg 2.23 6.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 15553 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 116.7 breaths/min 8.69 28.82 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15581 381
FHH/EurMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 425.52 beats/min 6.37 14.25 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15589 381
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 385.71 beats/min 6.11 16.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51279 481
FHH/EurMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 94.56 breaths/min 9.55 33.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18381 381
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 127.19 mmHg 1.83 5.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51636 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -16.95 beats/min 18.35 51.9 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50340 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 4.74 mmHg 3.69 9.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50376 481
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 -0.45 degrees C 0.14 0.48 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14131 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.44 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14150 381
FHH/EurMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 384.44 beats/min 16.52 46.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14700 381
FHH/EurMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 0.06 degrees C 0.27 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15989 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 0.0 null 0.02 0.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14758 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 18 123.86 mmHg 3.79 16.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14351 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 16 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17069 381
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 137.71 mmol/l 0.61 1.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36338 401
FHH/EurMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 5 116.95 mmHg 2.56 5.73 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 13766 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 495.78 beats/min 18.91 26.74 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13831 381
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 7 9.19 mg/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37293 401
FHH/EurMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 148.04 breaths/min 4.41 13.95 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17207 381
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 142.57 mmHg 3.01 8.51 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51746 481
FHH/EurMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 44.56 ml/min 3.3 9.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18188 381
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 84.71 mg/dl 4.64 12.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36711 401
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 6 13.2 mEq/d 1.8 4.41 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51892 481
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 246.95 beats/min 8.85 21.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48155 461
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 48 241.76 beats/min 5.15 35.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48260 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 11.17 ml/min/g 1.07 2.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46285 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 2.98 IU/g 1.84 4.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45709 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 8.54 ml/min/g 0.65 1.45 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46635 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 10.58 IU/g 3.03 7.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45365 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 143.57 mmHg 7.4 19.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45373 461
FHH/EurMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 46 post-ischemic value/pre-ischemic value x 100% 85.76 % 3.75 25.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48469 461
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 47.43 ml/min 3.32 11.01 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17468 381
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 328.76 beats/min 31.67 89.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47682 461
FHH/EurMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 62.74 % 13.68 33.5 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46834 461
FHH/EurMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 49.12 mmHg 9.62 23.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45888 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 158.4 mmHg 7.97 17.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45813 461
FHH/EurMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 115.7 mmHg 6.34 20.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45817 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 66.25 % 3.81 8.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48003 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 114.1 % 8.77 26.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44970 461
FHH/EurMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 72.49 % 3.79 10.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46027 461
FHH/EurMcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity male 70 days-84 days 158 1.09 x 1000 cells/ul 0.05 0.58 automated blood cell counting method 0 60882 527
FHH/EurMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 152.35 % 6.26 21.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54422 381
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70 days-84 days 25 33.08 g/dl 0.11 0.55 automated blood cell counting method 0 61179 527
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70 days-84 days 158 33.18 g/dl 0.07 0.93 automated blood cell counting method 0 61190 527
FHH/EurMcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 8 204.1 g 13.4 37.8 whole body digital scale 0 Moms and pups used in studies were fed Dyets 58452 526
FHH/EurMcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 8 292.9 g 8.2 23.1 whole body digital scale 0 Moms and pups used in studies were fed Dyets 58458 526
FHH/EurMcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70 days-84 days 25 4.45 mmol/l 0.15 0.74 flame atomic emission spectrometry 0 61333 527
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 7 1.69 g/dl 0.06 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39964 401
FHH/EurMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 109.9 mmHg 3.58 8.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45556 461
FHH/EurMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 99.0 % 0.68 1.93 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56194 522
FHH/EurMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56200 522
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 3 11.0 % 5.51 9.54 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56205 522
FHH/EurMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54688 522
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 17.73 ml/min/kg 1.67 6.01 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58646 526
FHH/EurMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 166.21 % 6.66 21.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53720 381
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 42.43 mmHg 3.78 10.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49797 461
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.11 mmHg x min x kg x ml-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 58863 526
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 32.2 % 9.09 20.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56271 522
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 1229.89 s 43.51 168.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50278 461
FHH/EurMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 153.5 beats/min 14.22 31.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19166 381
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 69.19 % 5.13 13.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48500 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 1379.23 s 73.12 163.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50099 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 1453.88 s 54.23 121.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50101 461
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 33.6 % 6.45 20.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54855 522
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 3 36.0 % 10.54 18.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55055 522
FHH/EurMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 14.4 % 6.38 14.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55071 522
FHH/EurMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 55.8 % 7.41 16.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57296 522
FHH/EurMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.76 g/mg 0.18 0.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57348 522
FHH/EurMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 2 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56475 522
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 8 0.28 null 0.01 0.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 57719 526
FHH/EurMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 13 60.31 U/l 3.75 13.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37730 401
FHH/EurMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 20 1.88 g/kg 0.04 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59709 526
FHH/EurMcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 51 219.2 g 6.9 49.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55447 522
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 13.1 ml/min/kg 0.52 1.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57852 526
FHH/EurMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 7 0.75 x 1000 cells/ul 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39365 401
FHH/EurMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 3 123.19 mmHg 13.56 23.49 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16024 381
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -11.7 beats/min 12.08 34.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51700 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 15.53 beats/min 17.94 50.74 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51795 481
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.34 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14885 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 0.0 null 0.02 0.03 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14895 381
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 121.77 mmHg 0.93 2.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51829 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 4.01 ng/ml/h 1.09 2.43 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51843 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 6.46 mmHg 2.32 6.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51863 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 7.64 beats/min 18.08 36.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50976 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 7.2 ng/ml/h 1.34 2.68 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51013 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 6.8 mmHg 2.91 6.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51019 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.14 ml/min 0.11 0.24 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51051 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 47.8 mmHg 3.54 7.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51420 481
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 7 1.94 mg/d 0.47 1.24 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51476 481
FHH/EurMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 156.95 % 6.03 20.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54216 381
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 2 142.46 mmHg 8.89 12.57 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50678 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -5.23 beats/min 21.31 56.37 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50686 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 25.72 mmHg 4.1 11.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50758 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 15.83 mmHg 5.72 12.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51335 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 0.91 mEq/d 0.16 0.46 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51515 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -19.53 beats/min 25.96 63.58 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51609 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 -22.66 beats/min 17.34 45.89 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51239 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 399.95 beats/min 7.51 23.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51253 481
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.41 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13645 381
FHH/EurMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 42 37.07 degrees C 0.1 0.66 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13623 381
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 366.2 beats/min 15.08 33.73 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50470 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 8 122.1 mmHg 1.91 5.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51627 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 30.91 mmHg 4.23 11.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51665 481
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17606 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 108.68 mmHg 1.76 4.31 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17696 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 37.25 degrees C 0.14 0.47 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17719 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 119.31 mmHg 7.58 20.05 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19520 381
FHH/EurMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 101.34 mmHg 5.02 15.07 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19527 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20140 381
FHH/EurMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20626 381
FHH/EurMcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 11 220.3 g 5.4 17.8 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17925 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 420.82 beats/min 24.13 72.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18102 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 431.68 beats/min 10.13 30.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18107 381
FHH/EurMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 37.4 degrees C 0.09 0.26 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18112 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 30.3 mmHg 2.44 4.88 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19698 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 108.53 mmHg 2.14 6.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15030 381
FHH/EurMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 21.3 mmHg 5.11 14.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15144 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 2.12 mmHg 4.91 12.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15181 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 134.35 mmHg 4.77 13.5 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14411 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.42 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14425 381
FHH/EurMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 96.33 breaths/min 6.62 18.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14446 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 -7.2 mmHg 1.09 2.17 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15503 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 129.83 breaths/min 11.4 39.49 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15585 381
FHH/EurMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 318.89 beats/min 20.99 36.36 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15593 381
FHH/EurMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 32.2 ml/min 2.64 7.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15618 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -9.37 mmHg 1.15 2.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15649 381
FHH/EurMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 438.2 beats/min 10.21 28.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15930 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 7.47 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15318 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.4 ml 0.02 0.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14619 381
FHH/EurMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 42 0.12 degrees C 0.06 0.39 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15733 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 104.81 mmHg 8.1 16.19 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15770 381
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 9.02 ng/ml/h 1.47 3.59 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50537 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 21.3 beats/min 54.9 77.64 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51921 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 130.75 mmHg 7.93 17.73 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51996 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 137.89 mmHg 7.62 15.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52007 481
FHH/EurMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 16 0.92 mEq/d 0.05 0.2 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52295 482
FHH/EurMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 39 1.44 ml/min 0.09 0.57 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52360 482
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 48 183.29 mg/d 13.89 96.23 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52407 482
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 514.24 beats/min 11.72 31.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14069 381
FHH/EurMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 106.42 mmHg 3.38 8.29 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17306 381
FHH/EurMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 144.58 breaths/min 7.24 24.03 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17211 381
FHH/EurMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 37.19 degrees C 0.17 0.55 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13853 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 123.11 mmHg 13.43 18.99 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13905 381
FHH/EurMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 3 490.57 beats/min 20.05 34.73 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13827 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 105.11 % 3.3 23.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53987 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 16 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19805 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 115.68 mmHg 3.64 10.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19868 381
FHH/EurMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 12 122.4 mmHg 1.96 6.8 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19886 381
FHH/EurMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 70.06 ml/min 4.37 15.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20814 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20861 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -6.79 mmHg 0.85 2.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20068 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 7.5 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20114 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.54 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20118 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 -0.04 null 0.01 0.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19915 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.43 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19728 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 107.32 mmHg 6.51 18.42 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18927 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 36.21 mmHg 3.01 6.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19000 381
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.44 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19013 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 27.43 mmHg 1.52 3.73 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19025 381
FHH/EurMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.37 ml 0.03 0.08 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16998 381
FHH/EurMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.94 g/dl 0.11 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 36309 401
FHH/EurMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 49 110.26 breaths/min 3.39 23.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18474 381
FHH/EurMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 93.79 mmHg 2.86 9.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18870 381
FHH/EurMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 103.05 mmHg 4.14 8.28 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18922 381
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 18 5.37 g/dl 0.08 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37014 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 18.9 pg 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37072 401
FHH/EurMcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70 days-84 days 170 42.3 cm 0.15 1.96 in vivo ruler method 0 63709 529
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 18 9.04 mg/dl 0.09 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36676 401
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 41.82 ml/min 3.95 15.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18715 381
FHH/EurMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 4.01 x 1000 cells/ul 0.35 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37306 401
FHH/EurMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 13 9.42 mg/dl 0.14 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36782 401
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 46 206.39 beats/min 9.64 65.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49008 461
FHH/EurMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during 2-3 min hypercapnia/control during standard conditions 243.47 % 13.48 46.71 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19264 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 4 -8.16 mmHg 2.47 4.94 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19328 381
FHH/EurMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 5.73 mmHg 0.13 0.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49229 461
FHH/EurMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.44 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20190 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 37.21 ml/min 1.74 12.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20272 381
FHH/EurMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 -0.02 null 0.01 0.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20566 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 -42.13 mmHg 3.04 9.6 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19466 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 16 -46.33 mmHg 4.5 18.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19484 381
FHH/EurMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 110.83 mmHg 3.46 8.48 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20395 381
FHH/EurMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 96.31 beats/min 29.67 78.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20428 381
FHH/EurMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 189.81 beats/min 16.06 35.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49823 461
FHH/EurMcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 6 1.35 g 0.05 0.12 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49826 461
FHH/EurMcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 6 1.59 g 0.07 0.16 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49827 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 7 13.77 % 4.64 12.29 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49628 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.37 IU/g 0.07 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49680 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 48 33.83 mmHg 1.68 11.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50059 461
FHH/EurMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 6 37.88 degrees C 0.17 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19186 381
FHH/EurMcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70 days-84 days 28 0.91 g 0.02 0.13 digital scale post excision weight measurement 0 63380 529
FHH/EurMcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70 days-84 days 172 0.21 g 0.0 0.04 digital scale post excision weight measurement 0 63319 529
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 7 22.0 mmol/l 0.98 2.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39087 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 18.71 mmol/l 1.6 4.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39090 401
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 51 18.31 mmol/l 0.54 3.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42125 401
FHH/EurMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70 days-84 days 28 189.79 g 2.74 14.52 whole body digital scale 0 63626 529
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 222.57 mg/dl 15.07 39.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39321 401
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 51 142.63 mmol/l 0.47 3.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39451 401
FHH/EurMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.31 x 1000 cells/ul 0.05 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39507 401
FHH/EurMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.99 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39523 401
FHH/EurMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.5 x 1000 cells/ul 0.13 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39359 401
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 51 105.61 U/l 4.06 28.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42833 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 49 0.88 x 1000 cells/ul 0.1 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43287 401
FHH/EurMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 171.56 % 5.03 15.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54515 381
FHH/EurMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 49 19.63 mmol/l 0.58 4.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43173 401
FHH/EurMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.31 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Dyets 43096 401
FHH/EurMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 43 146.1 % 3.65 23.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54426 381
FHH/EurMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 49 23.96 mmol/l 0.55 3.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43032 401
FHH/EurMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 8 0.81 g/kg 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 59021 526
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.4 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Dyets 40381 401
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 134.27 % 7.41 24.57 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53537 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 119.75 % 7.07 22.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53551 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 111.46 % 4.4 14.59 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53575 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 111.38 % 4.21 14.59 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53578 381
FHH/EurMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 178.46 % 11.58 36.63 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53583 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 139.48 % 6.01 20.81 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53594 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 112.07 % 7.16 22.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53732 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 136.94 % 11.45 34.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53735 381
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 0.12 mmHg x min x kg x ml-1 0.02 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 58869 526
FHH/EurMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 48 17.25 pg 0.05 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40240 401
FHH/EurMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 18 21.5 mg/dl 0.78 3.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40880 401
FHH/EurMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 51 24.51 mg/dl 0.7 5.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40891 401
FHH/EurMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 102.29 mmol/l 0.42 1.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 40525 401
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 31.97 g/dl 0.12 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40533 401
FHH/EurMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 184.29 mg/dl 8.66 22.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 40673 401
FHH/EurMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 47.43 % 1.05 2.96 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40679 401
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 2.03 mg/kg 0.4 1.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59187 526
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 16 52.99 % 0.9 3.61 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59309 526
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 49 9.31 mg/dl 0.26 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37657 401
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 16 3.71 x 1000 cells/ul 0.51 2.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40978 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 47 17.74 g/dl 0.17 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38031 401
FHH/EurMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 48 42.71 % 0.44 3.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41344 401
FHH/EurMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 7 1.79 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 41594 401
FHH/EurMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 7.39 mg/dl 0.41 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38226 401
FHH/EurMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38364 401
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.27 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59795 526
FHH/EurMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 13 14.92 mg/dl 0.77 2.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41775 401
FHH/EurMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 6 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 62774 528
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 16.98 ml/min/kg 1.54 4.37 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57712 526
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 3 14.05 ml/min/kg 0.89 1.54 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57715 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 0.69 null 0.07 0.16 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57745 526
FHH/EurMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 13.85 mmHg 4.05 5.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16284 381
FHH/EurMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 5 204.5 g 12.9 28.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55194 522
FHH/EurMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 51 234.9 g 4.6 33.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55212 522
FHH/EurMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 -7.09 null 0.15 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 57409 522
FHH/EurMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 50 -7.86 null 0.05 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55308 522
FHH/EurMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 99.8 % 0.2 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55376 522
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 53 13.26 ml/min/kg 0.46 3.37 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57661 526
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 28.22 IU/g 2.45 6.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48870 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 93.29 mmHg 8.38 22.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48728 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 135.29 mmHg 10.69 28.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48736 461
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 48 36.9 degrees C 0.13 0.9 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16636 381
FHH/EurMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.53 ml 0.02 0.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16661 381
FHH/EurMcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70 days-84 days 25 42.18 % 0.45 2.23 automated blood cell counting method 0 60667 527