BN/SsNHsd |
binary logarithm of pituitary gland wet weight |
sham surgical control condition (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252 days-266 days |
10 |
|
|
2.89 |
null |
0.08 |
0.24 |
post excision weight measurement |
pituitary gland |
0 |
|
0 |
|
|
logarithm of pituitary wet weight |
65769 |
331 |
BN/SsNHsd |
percentage of study population developing pituitary tumors that replace a portion of the gland during a period of time |
diethylstilbestrol (5 mg) (for 70 days) and surgical implantation (for 70 days) |
Pandey J, et al., Carcinogenesis 2004 May 27;. |
pituitary gland integrity trait |
not specified |
91 days
| 6 |
|
|
0.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
surgery implant |
70 |
days |
xco:0000295 |
|
69909 |
1240 |
BN/SsNHsd |
artery lumen area |
control condition |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery morphology trait |
male |
133 days-140 days |
12 |
CA = (IEL)2/4π |
|
0.45 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
error - % coefficient of variation |
68087 |
329 |
BN/SsNHsd |
artery tunica media thickness |
control condition |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery morphology trait |
male |
133 days-140 days |
12 |
MW=radius of entire vessel minus radius of circular area |
|
0.04 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
error - % coefficient of variation |
68091 |
329 |
BN/SsNHsd |
body weight |
specific pathogen-free condition |
NBRP Body Weight data |
body mass |
male |
70 days
| 6 |
|
|
230.1 |
g |
5.51 |
13.5 |
whole body digital scale |
|
|
|
0 |
|
|
|
70657 |
21 |
BN/SsNHsd |
heart weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
heart mass |
male |
70 days
| 6 |
|
|
3.2 |
g/kg |
0.05 |
0.12 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71430 |
41 |
BN/SsNHsd |
liver wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
liver mass |
male |
70 days
| 6 |
|
|
5.16 |
g |
0.25 |
0.61 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71433 |
41 |
BN/SsNHsd |
spleen weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
spleen mass |
male |
70 days
| 6 |
|
|
0.17 |
% |
0.0 |
0.01 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71440 |
41 |
BN/SsNHsd |
thymus wet weight |
diethylstilbestrol (5 mg) (for 84 days) and surgical implantation |
Gould KA, et al., Mamm Genome. 2006 May;17(5):451-64. |
thymus mass |
male |
147 days
| 15 |
|
|
66.0 |
mg |
4.39 |
17.0 |
post excision weight measurement |
|
0.0 |
subcutaneous implant |
84 |
days |
diethylstilbestrol |
|
69095 |
1121 |
BN/SsNHsd |
plasma albumin level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood albumin amount |
male |
70 days
| 6 |
|
|
0.33 |
g/l |
0.0 |
0.01 |
automated plasma albumin analysis |
|
|
|
0 |
|
Hitachi, model 7170 |
|
76567 |
1498 |
BN/SsNHsd |
plasma creatinine level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood creatinine amount |
male |
70 days
| 6 |
|
|
0.36 |
mg/dl |
0.01 |
0.02 |
automated plasma creatinine analysis |
|
|
|
0 |
|
Hitachi, model 7170 |
|
76576 |
1498 |
BN/SsNHsd |
timed urine volume |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine output |
male |
63 days
| 6 |
|
|
17.72 |
ml/d |
1.42 |
3.48 |
metabolic cage urine volume measurement method |
|
|
|
0 |
|
|
|
94796 |
1662 |
BN/SsNHsd |
urine sodium excretion rate to body weight ratio |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine sodium amount |
male |
63 days
| 6 |
|
|
0.01 |
uEq/min/g |
0.0 |
0.0 |
automated urine analysis |
|
|
|
0 |
|
Analytical intruments, PVA alpha II |
|
94799 |
1662 |
BN/SsNHsd |
artery neointimal hyperplastic lesion area including tunica media |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery integrity trait |
male |
119 days-133 days |
10 |
|
|
0.14 |
mm2 |
0.01 |
0.02 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110464 |
3107 |
BN/SsNHsd |
artery lumen area |
control condition |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
23 |
|
|
0.48 |
mm2 |
0.02 |
0.1 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110503 |
3107 |
BN/SsNHsd |
epididymal fat pad weight |
control condition |
Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28. |
epididymal fat pad mass |
male |
119 days
| 10 |
|
|
1.98 |
g |
0.11 |
0.36 |
scale |
|
|
|
0 |
|
|
|
138392 |
3200 |
BN/SsNHsd |
pituitary gland wet weight |
surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252 days-266 days |
10 |
|
|
0.01 |
g |
0.0 |
0.0 |
post excision weight measurement |
pituitary gland |
0.0 |
|
0 |
|
|
|
13102 |
331 |
BN/SsNHsd |
hepatocellular carcinoma tumor number |
N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 mg/kg) (for 210 days) then partial hepatectomy |
De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. |
liver integrity trait |
not specified |
0 days
| 10 |
|
|
1.3 |
null |
0.13 |
0.41 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
N-nitrosodiethylamine |
490 |
days |
|
|
68389 |
912 |
BN/SsNHsd |
percentage of study population developing unilateral renal agenesis during a period of time |
control condition |
Shull JD, et al., Mamm Genome. 2006 Jul;17(7):751-9. Epub 2006 Jul 14. |
kidney integrity trait |
female |
0 days
| 36 |
|
|
0.0 |
% |
|
|
necropsy |
|
0.0 |
|
0 |
|
|
|
69373 |
1157 |
BN/SsNHsd |
plasma aspartate aminotransferase activity level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood aspartate transaminase amount |
male |
70 days
| 6 |
|
|
63.0 |
U/l |
2.04 |
5.0 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76563 |
1498 |
BN/SsNHsd |
blood basophil count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
basophil quantity |
male |
70 days
| 6 |
|
|
0.0 |
% |
0.0 |
0.0 |
automated differential white blood cell count test |
|
|
|
0 |
|
May-Giemsa staining |
|
76582 |
1498 |
BN/SsNHsd |
percentage of study population developing pituitary tumors that replace the entire gland during a period of time |
diethylstilbestrol (5 mg) (for 70 days) and surgical implantation (for 70 days) |
Pandey J, et al., Carcinogenesis 2004 May 27;. |
pituitary gland integrity trait |
not specified |
91 days
| 6 |
|
|
0.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
surgery implant |
70 |
days |
xco:0000295 |
|
69910 |
1240 |
BN/SsNHsd |
body weight |
specific pathogen-free condition |
NBRP Body Weight data |
body mass |
male |
35 days
| 6 |
|
|
91.0 |
g |
0.29 |
0.7 |
whole body digital scale |
|
|
|
0 |
|
|
|
70658 |
21 |
BN/SsNHsd |
lesioned artery residual lumen area |
balloon angioplasty |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery integrity trait |
male |
133 days-140 days |
16 |
LS (lumen size) = CA - NIH area |
|
0.47 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
error - % coefficient of variation |
68103 |
329 |
BN/SsNHsd |
both adrenal glands wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
adrenal gland mass |
male |
70 days
| 6 |
|
|
47.6 |
mg |
2.08 |
5.1 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71437 |
41 |
BN/SsNHsd |
plasma alkaline phosphatase activity level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood alkaline phosphatase amount |
male |
70 days
| 6 |
|
|
149.0 |
IU/l |
2.86 |
7.0 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76565 |
1498 |
BN/SsNHsd |
plasma low density lipoprotein cholesterol level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood LDL cholesterol amount |
male |
70 days
| 6 |
|
|
10.0 |
mg/dl |
0.82 |
2.0 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76572 |
1498 |
BN/SsNHsd |
plasma urea nitrogen level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood urea nitrogen amount |
male |
70 days
| 6 |
|
|
8.85 |
mmol/l |
0.34 |
0.82 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76575 |
1498 |
BN/SsNHsd |
blood band neutrophil count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
neutrophil quantity |
male |
70 days
| 6 |
|
|
0.0 |
% |
0.0 |
0.0 |
automated differential white blood cell count test |
|
|
|
0 |
|
May-Giemsa staining |
band neutrophil % |
76584 |
1498 |
BN/SsNHsd |
timed urine volume to body weight ratio |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine output |
male |
63 days
| 6 |
|
|
0.06 |
ul/min/g |
0.0 |
0.01 |
metabolic cage urine volume measurement method |
|
|
|
0 |
|
|
|
94797 |
1662 |
BN/SsNHsd |
body temperature |
specific pathogen-free condition |
NBRP Body Temperature data |
body temperature trait |
male |
56 days-70 days |
6 |
|
serial mean |
37.9 |
degrees C |
0.16 |
0.4 |
digital rectal thermometry |
|
|
|
0 |
|
|
|
74912 |
22 |
BN/SsNHsd |
circular vessel area |
sham surgical control condition |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
11 |
|
|
0.28 |
mm2 |
0.03 |
0.1 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110495 |
3107 |
BN/SsNHsd |
artery neointimal hyperplastic lesion area to total wall area ratio |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery integrity trait |
male |
119 days-133 days |
10 |
|
|
35.2 |
% |
2.34 |
7.4 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110486 |
3107 |
BN/SsNHsd |
body weight |
control condition |
Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28. |
body mass |
male |
119 days
| 10 |
|
|
283.5 |
g |
4.47 |
14.12 |
body weighing method |
|
|
|
0 |
|
|
|
138388 |
3200 |
BN/SsNHsd |
retroperitoneal fat pad weight |
control condition |
Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28. |
retroperitoneal fat pad mass |
male |
119 days
| 10 |
|
|
1.06 |
g |
0.07 |
0.22 |
scale |
|
|
|
0 |
|
|
|
138391 |
3200 |
BN/SsNHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (between 196 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
259 days
| 13 |
|
|
0.0 |
null |
|
|
manual palpation method |
|
|
crystalline implant |
0 |
|
|
|
11381 |
81 |
BN/SsNHsd |
hematocrit |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
erythrocyte quantity |
male |
70 days
| 6 |
|
|
52.2 |
% |
0.49 |
1.2 |
automated cell/particle size/count analysis method |
|
|
|
0 |
|
Sysmex, F-800 type |
|
76555 |
1498 |
BN/SsNHsd |
prothrombin time |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood coagulation trait |
male |
70 days
| 6 |
|
|
17.7 |
s |
0.24 |
0.6 |
automated coagulometer method |
|
|
|
0 |
|
Sysmex, CA-3000 type |
|
76561 |
1498 |
BN/SsNHsd |
plasma glucose level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood glucose amount |
male |
70 days
| 6 |
|
|
134.0 |
mg/dl |
3.27 |
8.0 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76569 |
1498 |
BN/SsNHsd |
plasma phosphate level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood phosphate amount |
male |
70 days
| 6 |
|
|
6.4 |
mg/dl |
0.24 |
0.6 |
automated blood electrolyte analysis |
|
|
|
0 |
|
Hitachi, model 7170 |
|
76577 |
1498 |
BN/SsNHsd |
blood monocyte count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
monocyte quantity |
male |
70 days
| 6 |
|
|
0.0 |
% |
0.0 |
0.0 |
automated differential white blood cell count test |
|
|
|
0 |
|
May-Giemsa staining |
|
76587 |
1498 |
BN/SsNHsd |
percentage of study population developing mammary tumors during a period of time |
17 beta-estradiol (27.5 mg) (between 196 and 199 days) |
Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 |
mammary gland integrity trait |
female |
259 days
| 13 |
|
|
0.0 |
% |
|
|
manual palpation method |
|
0 |
crystalline implant |
0 |
|
|
|
65765 |
81 |
BN/SsNHsd |
liver tumorous lesion number |
N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy |
De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. |
liver integrity trait |
not specified |
0 days
| 7 |
|
|
155800.0 |
null |
19408.0 |
51348.74 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
N-nitrosodiethylamine |
224 |
days |
|
CMO:0001068 |
68350 |
912 |
BN/SsNHsd |
artery neointimal hyperplastic lesion area to total wall area ratio |
balloon angioplasty |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery integrity trait |
male |
133 days-140 days |
16 |
|
|
27.1 |
% |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
% nih area - error - % coefficient of variation |
68101 |
329 |
BN/SsNHsd |
brain wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
brain mass |
male |
70 days
| 6 |
|
|
1.91 |
g |
0.02 |
0.04 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71427 |
41 |
BN/SsNHsd |
brain weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
brain mass |
male |
70 days
| 6 |
|
|
0.87 |
% |
0.03 |
0.06 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71428 |
41 |
BN/SsNHsd |
both kidneys wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
kidney mass |
male |
70 days
| 6 |
|
|
1.16 |
g |
0.04 |
0.09 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71435 |
41 |
BN/SsNHsd |
both testes wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
testis mass |
male |
70 days
| 6 |
|
|
2.87 |
g |
0.07 |
0.16 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71441 |
41 |
BN/SsNHsd |
both testes wet weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
testis mass |
male |
70 days
| 6 |
|
|
1.31 |
% |
0.01 |
0.03 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71442 |
41 |
BN/SsNHsd |
thymus wet weight |
control condition |
Gould KA, et al., Mamm Genome. 2006 May;17(5):451-64. |
thymus mass |
male |
63 days
| 7 |
|
|
508.0 |
mg |
23.81 |
63.0 |
post excision weight measurement |
|
0.0 |
|
0 |
|
|
|
69092 |
1121 |
BN/SsNHsd |
absolute change in thymus weight |
control condition |
Gould KA, et al., Mamm Genome. 2006 May;17(5):451-64. |
thymus mass |
male |
147 days
| 7 |
|
|
285.0 |
mg |
|
|
post excision weight measurement |
|
0.0 |
|
0 |
|
|
|
69094 |
1121 |
BN/SsNHsd |
mean corpuscular volume |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
erythrocyte size trait |
male |
70 days
| 6 |
|
|
57.5 |
fl |
0.24 |
0.6 |
automated cell/particle size/count analysis method |
|
|
|
0 |
|
Sysmex, F-800 type |
|
76556 |
1498 |
BN/SsNHsd |
plasma albumin to plasma total protein ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood albumin amount |
male |
70 days
| 6 |
|
|
1.25 |
null |
0.03 |
0.07 |
automated plasma protein analysis |
|
|
|
0 |
|
Hitachi, model 7170 |
plasma albumin to plasma total protein ratio |
76568 |
1498 |
BN/SsNHsd |
plasma total cholesterol level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood cholesterol amount |
male |
70 days
| 6 |
|
|
59.0 |
mg/dl |
3.27 |
8.0 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76570 |
1498 |
BN/SsNHsd |
plasma chloride level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood chloride amount |
male |
70 days
| 6 |
|
|
106.0 |
mmol/l |
0.41 |
1.0 |
automated blood electrolyte analysis |
|
|
|
0 |
|
Analytical intruments, PVA alpha II |
|
76581 |
1498 |
BN/SsNHsd |
non-specified leukocyte count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
leukocyte quantity |
male |
70 days
| 6 |
|
|
0.0 |
% |
0.0 |
0.0 |
automated differential white blood cell count test |
|
|
|
0 |
|
May-Giemsa staining |
unidentified differential wbc |
76588 |
1498 |
BN/SsNHsd |
urine potassium excretion rate to body weight ratio |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine potassium amount |
male |
63 days
| 6 |
|
|
230.0 |
uEq/100g/6 hrs |
19.6 |
48.0 |
automated urine analysis |
|
|
|
0 |
|
Analytical intruments, PVA alpha II |
|
94801 |
1662 |
BN/SsNHsd |
systolic blood pressure |
specific pathogen-free condition |
NBRP Blood Pressure and Heart Rate data |
arterial blood pressure trait |
male |
56 days-70 days |
6 |
|
serial mean |
141.0 |
mmHg |
5.31 |
13.0 |
tail cuff photoplethysmography |
|
|
|
0 |
|
NP-NIBP Monitor MK-2000, Muromachi Kikai Co., Ltd, Japan |
|
74910 |
14 |
BN/SsNHsd |
artery neointimal hyperplastic lesion area |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery integrity trait |
male |
119 days-133 days |
10 |
|
|
0.08 |
mm2 |
0.0 |
0.01 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110492 |
3107 |
BN/SsNHsd |
artery neointimal hyperplastic lesion area to total wall area ratio |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery integrity trait |
male |
119 days-133 days |
10 |
|
|
46.3 |
% |
1.71 |
5.41 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110493 |
3107 |
BN/SsNHsd |
heart wet weight |
balloon angioplasty |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
heart mass |
male |
133 days-140 days |
12 |
regression of heart weight on body weight |
|
1.1 |
g |
|
|
post excision weight measurement |
|
0.0 |
|
56 |
days |
|
error - % coefficient of variation |
13079 |
329 |
BN/SsNHsd |
artery tunica media area |
control condition |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery morphology trait |
male |
133 days-140 days |
12 |
|
|
0.09 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
error - % coefficient of variation |
68089 |
329 |
BN/SsNHsd |
mean corpuscular hemoglobin concentration |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood hemoglobin amount |
male |
70 days
| 6 |
|
|
31.8 |
g/dl |
0.12 |
0.3 |
automated cell/particle size/count analysis method |
|
|
|
0 |
|
Sysmex, F-800 type |
|
76558 |
1498 |
BN/SsNHsd |
blood segmented neutrophil count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
neutrophil quantity |
male |
70 days
| 6 |
|
|
11.0 |
% |
2.04 |
5.0 |
automated differential white blood cell count test |
|
|
|
0 |
|
May-Giemsa staining |
segmented neutrophil % |
76585 |
1498 |
BN/SsNHsd |
artery lumen area |
balloon angioplasty |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery morphology trait |
male |
133 days-140 days |
16 |
CA = (IEL)2/4π |
|
0.5 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
error - % coefficient of variation |
68093 |
329 |
BN/SsNHsd |
artery tunica media thickness |
balloon angioplasty |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery morphology trait |
male |
133 days-140 days |
16 |
MW=radius of entire vessel minus radius of circular area |
|
0.03 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
error - % coefficient of variation |
68097 |
329 |
BN/SsNHsd |
lung wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
lung mass |
male |
70 days
| 6 |
|
|
1.15 |
g |
0.02 |
0.06 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71431 |
41 |
BN/SsNHsd |
lung weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
lung mass |
male |
70 days
| 6 |
|
|
0.53 |
% |
0.01 |
0.02 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71432 |
41 |
BN/SsNHsd |
both adrenal glands weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
adrenal gland mass |
male |
70 days
| 6 |
|
|
21.7 |
mg/100g |
0.98 |
2.4 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71438 |
41 |
BN/SsNHsd |
mean corpuscular hemoglobin |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood hemoglobin amount |
male |
70 days
| 6 |
|
|
18.3 |
pg |
0.04 |
0.1 |
automated cell/particle size/count analysis method |
|
|
|
0 |
|
Sysmex, F-800 type |
|
76557 |
1498 |
BN/SsNHsd |
white blood cell count |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
leukocyte quantity |
male |
70 days
| 6 |
|
|
8.2 |
x 1000 cells/ul |
0.53 |
1.3 |
automated cell/particle size/count analysis method |
|
|
|
0 |
|
Sysmex, F-800 type |
|
76559 |
1498 |
BN/SsNHsd |
activated partial thromboplastin time |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood coagulation trait |
male |
70 days
| 6 |
|
|
12.3 |
s |
0.41 |
1.0 |
automated coagulometer method |
|
|
|
0 |
|
Sysmex, CA-3000 type |
|
76562 |
1498 |
BN/SsNHsd |
plasma triglyceride level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood triglyceride amount |
male |
70 days
| 6 |
|
|
0.35 |
mmol/l |
0.02 |
0.05 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76573 |
1498 |
BN/SsNHsd |
total plasma calcium level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood calcium amount |
male |
70 days
| 6 |
|
|
9.4 |
mg/dl |
0.08 |
0.2 |
automated blood electrolyte analysis |
|
|
|
0 |
|
Hitachi, model 7170 |
|
76578 |
1498 |
BN/SsNHsd |
plasma potassium level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood potassium amount |
male |
70 days
| 6 |
|
|
4.8 |
mmol/l |
0.16 |
0.39 |
automated blood electrolyte analysis |
|
|
|
0 |
|
Analytical intruments, PVA alpha II |
|
76580 |
1498 |
BN/SsNHsd |
blood eosinophil count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
eosinophil quantity |
male |
70 days
| 6 |
|
|
1.0 |
% |
0.41 |
1.0 |
automated differential white blood cell count test |
|
|
|
0 |
|
May-Giemsa staining |
|
76583 |
1498 |
BN/SsNHsd |
urine potassium level |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine potassium amount |
male |
63 days
| 6 |
|
|
119.3 |
mmol/l |
9.55 |
23.4 |
automated urine analysis |
|
|
|
0 |
|
Analytical intruments, PVA alpha II |
|
94800 |
1662 |
BN/SsNHsd |
urine chloride excretion rate to body weight ratio |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine chloride amount |
male |
63 days
| 6 |
|
|
328.0 |
uEq/100g/6 hrs |
31.44 |
77.0 |
automated urine analysis |
|
|
|
0 |
|
|
|
94803 |
1662 |
BN/SsNHsd |
artery neointimal hyperplastic lesion area including tunica media |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery integrity trait |
male |
119 days-133 days |
14 |
|
|
0.18 |
mm2 |
0.0 |
0.02 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110491 |
3107 |
BN/SsNHsd |
circular vessel area |
control condition |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
11 |
|
|
0.35 |
mm2 |
389.0 |
1290.17 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110494 |
3107 |
BN/SsNHsd |
circular vessel area |
control condition |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
23 |
|
|
0.48 |
mm2 |
0.02 |
0.1 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110502 |
3107 |
BN/SsNHsd |
circular vessel area |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
23 |
|
|
0.47 |
mm2 |
0.03 |
0.15 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110504 |
3107 |
BN/SsNHsd |
nose to rump body mass index |
control condition |
Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28. |
body mass |
male |
119 days
| 10 |
|
|
7.63 |
(g/cm2) x 10 |
0.19 |
0.6 |
body weighing method |
|
|
|
0 |
|
|
|
138389 |
3200 |
BN/SsNHsd |
pituitary gland wet weight |
sham surgical control condition (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252 days-266 days |
10 |
|
|
0.01 |
g |
0.0 |
0.0 |
post excision weight measurement |
pituitary gland |
0 |
|
0 |
|
|
|
13099 |
331 |
BN/SsNHsd |
percentage of study population developing unilateral renal agenesis during a period of time |
control condition |
Shull JD, et al., Mamm Genome. 2006 Jul;17(7):751-9. Epub 2006 Jul 14. |
kidney integrity trait |
male |
0 days
| 43 |
|
|
0.0 |
% |
|
|
necropsy |
|
0.0 |
|
0 |
|
|
|
69375 |
1157 |
BN/SsNHsd |
artery tunica media area |
balloon angioplasty |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery morphology trait |
male |
133 days-140 days |
16 |
|
|
0.07 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
media area - error - % coefficient of variation |
68095 |
329 |
BN/SsNHsd |
body weight |
specific pathogen-free condition |
NBRP Body Weight data |
body mass |
male |
42 days
| 6 |
|
|
137.1 |
g |
1.59 |
3.9 |
whole body digital scale |
|
|
|
0 |
|
|
|
70656 |
21 |
BN/SsNHsd |
plasma total protein level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood total protein amount |
male |
70 days
| 6 |
|
|
60.0 |
mg/ml |
0.41 |
1.0 |
automated plasma total protein analysis |
|
|
|
0 |
|
Hitachi, model 7170 |
|
76566 |
1498 |
BN/SsNHsd |
plasma high density lipoprotein cholesterol level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood HDL cholesterol amount |
male |
70 days
| 6 |
|
|
38.2 |
mg/dl |
2.16 |
5.3 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76571 |
1498 |
BN/SsNHsd |
plasma total bilirubin level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood bilirubin amount |
male |
70 days
| 6 |
|
|
0.01 |
mg/dl |
0.0 |
0.01 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
total plasma bilirubin level |
76574 |
1498 |
BN/SsNHsd |
plasma sodium level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood sodium amount |
male |
70 days
| 6 |
|
|
142.6 |
mmol/l |
0.41 |
1.0 |
automated blood electrolyte analysis |
|
|
|
0 |
|
Analytical intruments, PVA alpha II |
|
76579 |
1498 |
BN/SsNHsd |
binary logarithm of pituitary gland wet weight |
surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) |
Shull JD, et al., Mamm Genome. 2007 Sep 18;. |
pituitary gland mass |
female |
252 days-266 days |
10 |
|
|
3.79 |
null |
0.07 |
0.21 |
post excision weight measurement |
pituitary gland |
0 |
|
0 |
|
|
logarithm of pituitary wet weight |
65768 |
331 |
BN/SsNHsd |
percentage of study population developing pituitary gland hyperplastic lesions during a period of time |
diethylstilbestrol (5 mg) (for 70 days) and surgical implantation (for 70 days) |
Pandey J, et al., Carcinogenesis 2004 May 27;. |
pituitary gland integrity trait |
not specified |
91 days
| 6 |
|
|
100.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
surgery implant |
70 |
days |
xco:0000295 |
|
69908 |
1240 |
BN/SsNHsd |
percentage of study population developing pituitary tumors that invade the glandular capsule during a period of time |
diethylstilbestrol (5 mg) (for 70 days) and surgical implantation (for 70 days) |
Pandey J, et al., Carcinogenesis 2004 May 27;. |
pituitary gland integrity trait |
not specified |
91 days
| 6 |
|
|
0.0 |
% |
|
|
ex vivo light microscopy |
|
0.0 |
surgery implant |
70 |
days |
xco:0000295 |
|
69911 |
1240 |
BN/SsNHsd |
artery neointimal hyperplastic lesion area |
balloon angioplasty |
Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. |
iliac artery integrity trait |
male |
133 days-140 days |
16 |
|
|
0.03 |
mm2 |
|
|
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
nih area - error - % coefficient of variation |
68099 |
329 |
BN/SsNHsd |
heart wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
heart mass |
male |
70 days
| 6 |
|
|
0.7 |
g |
0.02 |
0.05 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71429 |
41 |
BN/SsNHsd |
liver weight as percentage of body weight |
specific pathogen-free condition |
NBRP Organ Weight data |
liver mass |
male |
70 days
| 6 |
|
|
2.35 |
% |
0.06 |
0.14 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71434 |
41 |
BN/SsNHsd |
both kidneys wet weight as percentage of body weight |
specific pathogen-free condition |
NBRP Organ Weight data |
kidney mass |
male |
70 days
| 6 |
|
|
0.53 |
% |
0.01 |
0.02 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71436 |
41 |
BN/SsNHsd |
spleen wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
spleen mass |
male |
70 days
| 6 |
|
|
0.38 |
g |
0.02 |
0.04 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
0 |
|
|
|
71439 |
41 |
BN/SsNHsd |
blood hemoglobin level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood hemoglobin amount |
male |
70 days
| 6 |
|
|
16.6 |
g/dl |
0.2 |
0.5 |
automated cell/particle size/count analysis method |
|
|
|
0 |
|
Sysmex, F-800 type |
|
76554 |
1498 |
BN/SsNHsd |
platelet count |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
platelet quantity |
male |
70 days
| 6 |
|
|
928.0 |
x 1000 cells/ul |
18.78 |
46.0 |
automated cell/particle size/count analysis method |
|
|
|
0 |
|
Sysmex, F-800 type |
|
76560 |
1498 |
BN/SsNHsd |
plasma alanine aminotransferase activity level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood alanine transaminase amount |
male |
70 days
| 6 |
|
|
22.0 |
U/l |
1.63 |
4.0 |
automated plasma analysis |
|
|
|
0 |
|
PMID:15591307 |
|
76564 |
1498 |
BN/SsNHsd |
blood lymphocyte count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
lymphocyte quantity |
male |
70 days
| 6 |
|
|
88.0 |
% |
2.04 |
5.0 |
automated differential white blood cell count test |
|
|
|
0 |
|
May-Giemsa staining |
|
76586 |
1498 |
BN/SsNHsd |
urine sodium level |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine sodium amount |
male |
63 days
| 6 |
|
|
129.3 |
mmol/l |
7.68 |
18.8 |
automated urine analysis |
|
|
|
0 |
|
Analytical intruments, PVA alpha II |
|
94798 |
1662 |
BN/SsNHsd |
urine chloride level |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine chloride amount |
male |
63 days
| 6 |
|
|
170.0 |
mEq/L |
15.11 |
37.0 |
automated urine analysis |
|
|
|
0 |
|
|
|
94802 |
1662 |
BN/SsNHsd |
percentage of study population developing hepatocellular carcinoma during a period of time |
N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 490 days) then partial hepatectomy |
De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. |
liver integrity trait |
not specified |
0 days
| 10 |
|
|
10.0 |
% |
|
|
necropsy |
|
0.0 |
N-nitrosodiethylamine |
490 |
days |
|
CMO:0001068 |
96758 |
912 |
BN/SsNHsd |
heart rate |
specific pathogen-free condition |
NBRP Blood Pressure and Heart Rate data |
heart pumping trait |
male |
56 days-70 days |
6 |
|
serial mean |
411.0 |
beats/min |
12.66 |
31.0 |
tail cuff photoplethysmography |
|
|
|
0 |
|
NP-NIBP Monitor MK-2000, Muromachi Kikai Co., Ltd, Japan |
|
74911 |
14 |
BN/SsNHsd |
artery lumen area |
control condition |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
11 |
|
|
0.35 |
mm2 |
0.04 |
0.13 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110496 |
3107 |
BN/SsNHsd |
circular vessel area |
sham surgical control condition |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
11 |
|
|
0.28 |
mm2 |
0.03 |
0.1 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110497 |
3107 |
BN/SsNHsd |
artery lumen area |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
23 |
|
|
0.41 |
mm2 |
0.03 |
0.13 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110505 |
3107 |
BN/SsNHsd |
circular vessel area |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery morphology trait |
male |
119 days-133 days |
23 |
|
|
0.47 |
mm2 |
0.03 |
0.15 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110510 |
3107 |
BN/SsNHsd |
artery neointimal hyperplastic lesion area |
balloon angioplasty |
Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. |
iliac artery integrity trait |
male |
119 days-133 days |
10 |
|
|
0.05 |
mm2 |
0.01 |
0.02 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
|
0 |
|
|
|
110475 |
3107 |
BN/SsNHsd |
nose to tail body mass index |
control condition |
Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28. |
body mass |
male |
119 days
| 10 |
|
|
2.18 |
(g/cm2) x 10 |
0.04 |
0.14 |
body weighing method |
|
|
|
0 |
|
|
|
138390 |
3200 |
BN/SsNHsd |
thymus wet weight |
control condition |
Gould KA, et al., Mamm Genome. 2006 May;17(5):451-64. |
thymus mass |
male |
147 days
| 7 |
|
|
223.0 |
mg |
7.94 |
21.0 |
post excision weight measurement |
|
0.0 |
|
0 |
|
|
|
69093 |
1121 |
BN/SsNHsd |
volume of individual liver tumorous lesion |
N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy |
De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. |
liver integrity trait |
not specified |
0 days
| 7 |
|
|
0.12 |
cm3 x 10000 |
0.03 |
0.07 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
N-nitrosodiethylamine |
224 |
days |
|
|
68352 |
912 |
BN/SsNHsd |
volume of liver occupied by tumorous lesions as percentage of total liver volume |
N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy |
De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. |
liver integrity trait |
not specified |
0 days
| 7 |
|
|
19.83 |
% |
2.09 |
5.53 |
ex vivo light microscopy with digital image analysis |
|
0.0 |
N-nitrosodiethylamine |
224 |
days |
|
|
68354 |
912 |
BN/SsNHsd |
red blood cell count |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
erythrocyte quantity |
male |
70 days
| 6 |
|
|
9.09 |
x 10E6 cells/ul |
0.1 |
0.25 |
automated cell/particle size/count analysis method |
|
|
|
0 |
|
Sysmex, F-800 type |
|
76553 |
1498 |