Phenominer Database Results (195 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio controlled NG-nitroarginine methyl ester content in acidified drinking water (8-13 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 8 6.0 % 2.0 5.66 ex vivo light microscopy with histochemistry 0.0 0 67953 751
ACI.FHH-(D1Rat324-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio controlled NG-nitroarginine methyl ester content in acidified drinking water (8-13 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 7 16.0 % 5.0 13.23 ex vivo light microscopy with histochemistry 0.0 0 67955 751
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 9 8.0 % 2.0 6.0 ex vivo light microscopy with histochemistry 0.0 0 67960 751
AR-Ednrbsl/Hkv percentage of study population developing colonic aganglionosis during a period of time specific pathogen-free condition Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7. colorectal integrity trait female 14 days 15 100.0 % ex vivo light microscopy with histochemistry 0.0 0 102829 2741
SS/NEisSlc number of nucleated cells per kidney glomerulus controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. kidney glomerulus morphology trait male 91 days 6 51.7 null 1.2 2.94 ex vivo light microscopy with histochemistry 0.0 0 100729 2519
SD kidney sclerotic glomeruli count to total glomeruli count ratio sham surgical control condition (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 6 1.9 % 0.49 1.2 ex vivo light microscopy with histochemistry 0.0 sham unx 28 days 101603 2602
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 6 25.3 % 4.53 11.1 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101606 2602
SHR/N-cp kidney sclerotic glomeruli count to total glomeruli count ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney glomerulus integrity trait male 168 days-196 days 8 16.0 % 3.0 8.49 ex vivo light microscopy with histochemistry 0.0 0 101526 2601
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137 days-144 days 5 8.4 null 0.49 1.1 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105465 3016
LEW/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 10 days 5 51.1 um 1.34 3.0 ex vivo light microscopy with histochemistry 0.0 0 109361 3137
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (600 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81 days-88 days 5 10.5 null 0.42 0.95 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105453 3016
SHRSP/A3NCrl percentage of study population developing cerebral beta-amyloid deposits during a period of time control condition Pirici D, etal., Brain Pathol. 2017 Mar;27(2):169-180. doi: 10.1111/bpa.12384. Epub 2016 May 30. cerebral cortex integrity trait male 84 days-308 days 80 23.0 % ex vivo light microscopy with histochemistry 0.0 0 107916 3099
SHRSP/A3NCrl percentage of study population developing kidney tubulointerstitial damage during a period of time control condition Pirici D, etal., Brain Pathol. 2017 Mar;27(2):169-180. doi: 10.1111/bpa.12384. Epub 2016 May 30. kidney integrity trait male 98 days-308 days 80 85.0 % ex vivo light microscopy with histochemistry 0.0 0 percentage of study population developing kidney tubulointerstitial damage during a period of time (CMO:0003649) 107919 3099
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (45 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 16.2 / 100 um 5.5 12.3 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107363 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 2.9 / 100 um 3.0 6.71 ex vivo light microscopy with histochemistry 0.0 0 contralateral control eye 107368 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (225 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 2.1 / 100 um 1.9 4.25 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107371 3082
SHRSP/A3N kidney glomerular lesion count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney glomerulus integrity trait male 126 days-182 days 0 76.5 /section 7.0 ex vivo light microscopy with histochemistry renal glomerulus 0.0 0 107539 3090
SHRSP/A3N kidney total tubule cast count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 21.0 /section 5.0 ex vivo light microscopy with histochemistry 0.0 0 107554 3090
W/Kyo capillary number to soleus muscle fiber number ratio running on treadmill (15 m/min) (for 1 hours) Kondo H, etal., Muscle Nerve. 2015 Mar;51(3):391-9. doi: 10.1002/mus.24316. Epub 2015 Jan 6. skeletal muscle capillary amount male 63 days 6 1.95 null 0.12 0.29 ex vivo light microscopy with histochemistry 0.0 0 108120 3110
MWF/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 10 days 5 0.64 mm 0.02 0.05 ex vivo light microscopy with histochemistry 0.0 0 109330 3137
MWF/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 150 days 5 2.89 mm 1.29 2.89 ex vivo light microscopy with histochemistry 0.0 0 109336 3137
SHRSP/A3NCrl percentage of study population developing cerebral small vessel thrombosis and adjacent tissue infarction during a period of time control condition Pirici D, etal., Brain Pathol. 2017 Mar;27(2):169-180. doi: 10.1111/bpa.12384. Epub 2016 May 30. cerebral cortex integrity trait male 84 days-308 days 80 9.0 % ex vivo light microscopy with histochemistry 0.0 0 107918 3099
SHRSP/A3N kidney glomerular lesion count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney glomerulus integrity trait male 210 days-224 days 0 6.0 /section 2.0 ex vivo light microscopy with histochemistry 0.0 0 107476 3088
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio nondamaging retinal laser therapy (50 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 8 2.7 / 100 um 2.0 5.66 ex vivo light microscopy with histochemistry 0.0 NRT 161 days experimental eye 109069 3082
MWF/Ztm kidney sclerotic glomeruli count to total glomeruli count ratio standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. kidney glomerulus integrity trait male 140 days 8 median 2.2 % ex vivo light microscopy with histochemistry left kidney 0.0 0 109985 3162
MWF/Ztm kidney sclerotic glomeruli count to total glomeruli count ratio controlled lisinopril content drinking water (50 mg/l) (for 70 days) Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. kidney glomerulus integrity trait male 210 days 7 median 2.6 % ex vivo light microscopy with histochemistry left kidney 0.0 0 109987 3162
BDIX/OrlCrl number of large metastatic liver tumors in the right liver DHD/K12/TRb cells (2 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group B 111165 3195
BDIX/OrlCrl number of large metastatic liver tumors in the left liver DHD/K12/TRb cells (2 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group B 111171 3195
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then isolated lung perfusion with Hespan buffer (1 ml/min) (for 0.3 hours) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 4 617.0 null 37.0 74.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 2 111177 3197
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 13.2 x 10E3 um2 3.3 13.61 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107511 2378
BDIX/OrlCrl number of small metastatic liver tumors DHD/K12/TRb cells (2 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 17.0 null 0.89 2.0 ex vivo light microscopy with histochemistry 0.0 30 days group B 111059 3195
BDIX/OrlCrl number of large metastatic liver tumors DHD/K12/TRb cells (3 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group C 111160 3195
WKY/N kidney tubule regeneration foci count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 0.5 /section 0.4 ex vivo light microscopy with histochemistry 0.0 0 foci of tubular regeneration 107483 3088
SHRSP/A3N kidney tubule regeneration foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 6.4 /section 1.0 ex vivo light microscopy with histochemistry 0.0 0 foci of tubular regeneration 107485 3088
WKY/N interstitial nephritis foci count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 0.9 /section 0.4 ex vivo light microscopy with histochemistry 0.0 0 foci of interstitial nephritis 107487 3088
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 15.8 x 10E3 um2 4.0 16.0 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107463 2378
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 11 13.0 % 2.0 6.63 ex vivo light microscopy with histochemistry 0.0 0 67959 751
AR-Ednrbsl/Hkv percentage of study population developing colonic aganglionosis during a period of time specific pathogen-free condition Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7. colorectal integrity trait male 14 days 17 100.0 % ex vivo light microscopy with histochemistry 0.0 0 102828 2741
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 10 2.0 % 1.0 3.16 ex vivo light microscopy with histochemistry 0.0 0 67957 751
SD percentage of study population developing anorectal malformation during a period of time in utero condition (for 7 days) and corn oil (for 7 days) Jiang JT, et al., Toxicology. 2015 Dec 2;338:77-85. doi: 10.1016/j.tox.2015.10.006. Epub 2015 Oct 26. anorectal integrity trait male 1 days 0 0.0 % ex vivo light microscopy with histochemistry 1.0 0 anorectal malformation incidence 98734 2158
SS/NEisSlc number of nucleated cells per kidney glomerulus controlled sodium content diet (0.3 %) (for 91 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. kidney glomerulus morphology trait male 91 days 6 41.2 null 1.37 3.36 ex vivo light microscopy with histochemistry 0.0 0 100727 2519
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 8 31.0 % 5.66 16.0 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101629 2602
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 7 37.2 % 10.02 26.5 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101604 2602
SHR/N-cp kidney sclerotic glomeruli count to total glomeruli count ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney glomerulus integrity trait male 168 days-196 days 8 9.0 % 4.0 11.31 ex vivo light microscopy with histochemistry 0.0 0 101527 2601
MWF/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 20 days 5 62.5 um 0.98 2.2 ex vivo light microscopy with histochemistry 0.0 0 109356 3137
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137 days-144 days 5 10.1 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105464 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137 days-144 days 5 10.7 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105463 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (10 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81 days-88 days 5 11.3 null 0.32 0.72 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105451 3016
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (180 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 2.5 / 100 um 1.5 3.35 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107369 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 1.8 / 100 um 1.9 4.25 ex vivo light microscopy with histochemistry 0.0 0 contralateral control eye 107372 3082
WKY/N kidney total tubule cast count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 1.0 /section 1.0 ex vivo light microscopy with histochemistry 0.0 0 107553 3090
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 19.3 x 10E3 um2 4.8 19.79 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107461 2378
MWF/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 45 days 5 2.25 mm 0.05 0.12 ex vivo light microscopy with histochemistry 0.0 0 109333 3137
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 16.4 x 10E3 um2 4.1 16.4 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107464 2378
BDIX/OrlCrl small liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (0.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.8 mm 0.22 0.5 ex vivo light microscopy with histochemistry 0.0 30 days group 1 111080 3195
BDIX/OrlCrl small liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.9 mm 0.22 0.5 ex vivo light microscopy with histochemistry 0.0 30 days group 2 111081 3195
BDIX/OrlCrl number of large metastatic liver tumors DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 1.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 3 111163 3195
BDIX/OrlCrl number of large metastatic liver tumors in the left liver DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group A 111170 3195
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 11 8.7 x 10E3 um2 2.6 8.62 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107510 2378
MWF/Ztm healthy glomeruli to total glomeruli ratio controlled lisinopril content drinking water (80 mg/l) (for 70 days) Remuzzi A, etal., Kidney Int. 2006 Apr;69(7):1124-30. doi: 10.1038/sj.ki.5000060. kidney glomerulus integrity trait male 420 days 9 23.0 % ex vivo light microscopy with histochemistry glomerular capillary 0.0 0 healthy glomeruli to total glomeruli ratio (CMO:0003865) 110985 3158
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then floxuridine (1 mg/kg/d) (for 7 days) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 5 290.0 null 47.85 107.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 1 111176 3197
BDIX/OrlCrl small liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (2 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 1.2 mm 0.31 0.7 ex vivo light microscopy with histochemistry 0.0 30 days group B 111078 3195
SHRSP/A3N kidney glomerular lesion count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney glomerulus integrity trait male 126 days-182 days 0 1.4 /section 1.0 ex vivo light microscopy with histochemistry renal glomerulus 0.0 0 107540 3090
WKY/N interstitial nephritis foci count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 0.5 /section 0.3 ex vivo light microscopy with histochemistry 0.0 0 107549 3090
SHRSP/A3N interstitial nephritis foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 8.5 /section 1.2 ex vivo light microscopy with histochemistry 0.0 0 107551 3090
BDIX/OrlCrl large liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 10.1 mm 0.03 0.06 ex vivo light microscopy with histochemistry 0.0 30 days group 2 111084 3195
BDIX/OrlCrl number of small metastatic liver tumors DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (0.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 11.0 null 0.45 1.0 ex vivo light microscopy with histochemistry 0.0 30 days group 1 111061 3195
BDIX/OrlCrl number of small metastatic liver tumors DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 12.0 null 1.34 3.0 ex vivo light microscopy with histochemistry 0.0 30 days group 2 111062 3195
BDIX/OrlCrl number of large metastatic liver tumors DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (0.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 1.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 1 111161 3195
SHRSP/A3N interstitial nephritis foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 2.4 /section 0.8 ex vivo light microscopy with histochemistry 0.0 0 foci of interstitial nephritis 107490 3088
WKY/N kidney total tubule cast count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 0.6 /section 0.3 ex vivo light microscopy with histochemistry 0.0 0 total tubular casts 107491 3088
WKY/N renal fibrosis foci count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 16.0 /section 1.0 ex vivo light microscopy with histochemistry 0.0 0 foci of renal fibrosis 107495 3088
SS/NEisSlc neuron count controlled cilazapril content drinking water (0.94 mg/kg/d) (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. hippocampus neuron quantity not specified 547 days 10 1491.0 cells/mm2 57.0 180.25 ex vivo light microscopy with histochemistry 0.0 0 107467 2339
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then isolated lung perfusion with floxuridine (3.5 mg/ml) (for 0.3 hours) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 5 421.0 null 25.94 58.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 3 111183 3197
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then isolated lung perfusion with floxuridine (14 mg/ml) (for 0.3 hours) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 7 11.0 null 2.27 6.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 5 111185 3197
SR/NEisSlc number of nucleated cells per kidney glomerulus controlled sodium content diet (0.3 %) (for 91 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. kidney glomerulus morphology trait male 91 days 6 33.0 null 0.75 1.84 ex vivo light microscopy with histochemistry 0.0 0 100728 2519
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 8 5.0 % 1.0 2.83 ex vivo light microscopy with histochemistry 0.0 0 67956 751
ACI.FHH-(D1Rat324-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 8 9.0 % 3.0 8.49 ex vivo light microscopy with histochemistry 0.0 0 67958 751
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 98 days 15 6.0 % 1.0 3.87 ex vivo light microscopy with histochemistry 0.0 0 68044 751
FHH/Eur kidney sclerotic glomeruli count to total glomeruli count ratio controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 98 days 15 13.0 % 1.0 3.87 ex vivo light microscopy with histochemistry 0.0 0 68046 751
SS/NEisSlc number of nucleated cells per kidney glomerulus controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. kidney glomerulus morphology trait male 91 days 12 77.8 null 1.44 4.99 ex vivo light microscopy with histochemistry 0.0 0 100726 2519
SD percentage of study population developing anorectal malformation during a period of time in utero condition (for 7 days) and dibutyl phthalate (850 mg/kg/d) (for 7 days) Jiang JT, et al., Toxicology. 2015 Dec 2;338:77-85. doi: 10.1016/j.tox.2015.10.006. Epub 2015 Oct 26. anorectal integrity trait male 1 days 43 39.5 % ex vivo light microscopy with histochemistry 1.0 0 anorectal malformation incidence 98733 2158
SHR/N-cp kidney sclerotic glomeruli count to total glomeruli count ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney glomerulus integrity trait male 140 days-168 days 8 4.0 % 1.0 2.83 ex vivo light microscopy with histochemistry 0.0 0 101528 2601
MWF/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 45 days 5 105.0 um 2.15 4.8 ex vivo light microscopy with histochemistry 0.0 0 109357 3137
MWF/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 150 days 5 147.8 um 3.94 8.8 ex vivo light microscopy with histochemistry 0.0 0 109360 3137
LEW/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 100 days 5 118.2 um 1.52 3.4 ex vivo light microscopy with histochemistry 0.0 0 109365 3137
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count vehicle control condition (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137 days-144 days 5 10.5 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105462 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81 days-88 days 5 11.3 null 0.37 0.83 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105450 3016
SHRSP/A3NCrl percentage of study population developing cerebral small perivascular bleeds and no beta-amyloid deposits during a period of time control condition Pirici D, etal., Brain Pathol. 2017 Mar;27(2):169-180. doi: 10.1111/bpa.12384. Epub 2016 May 30. cerebral cortex integrity trait male 84 days-308 days 62 26.0 % ex vivo light microscopy with histochemistry 0.0 0 107922 3099
SHRSP/A3N kidney glomerular lesion count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney glomerulus integrity trait male 126 days-182 days 0 8.8 /section 2.7 ex vivo light microscopy with histochemistry renal glomerulus 0.0 0 107538 3090
MWF/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 20 days 5 0.97 mm 0.04 0.1 ex vivo light microscopy with histochemistry 0.0 0 109331 3137
MWF/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 100 days 5 2.63 mm 0.06 0.13 ex vivo light microscopy with histochemistry 0.0 0 109335 3137
LEW/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 20 days 5 1.0 mm 0.04 0.08 ex vivo light microscopy with histochemistry 0.0 0 109338 3137
LEW/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 45 days 5 2.34 mm 0.07 0.16 ex vivo light microscopy with histochemistry 0.0 0 109339 3137
LEW/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 100 days 5 2.75 mm 0.05 0.11 ex vivo light microscopy with histochemistry 0.0 0 109341 3137
SHRSP/A3N kidney glomerular lesion count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney glomerulus integrity trait male 210 days-224 days 0 4.0 /section 2.0 ex vivo light microscopy with histochemistry 0.0 0 107478 3088
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 8 2.3 / 100 um 1.3 3.68 ex vivo light microscopy with histochemistry 0.0 0 contralateral control eye 109068 3082
SHRSP/A3NCrl percentage of study population developing cerebral small perivascular bleeds during a period of time control condition Pirici D, etal., Brain Pathol. 2017 Mar;27(2):169-180. doi: 10.1111/bpa.12384. Epub 2016 May 30. cerebral cortex integrity trait male 84 days-308 days 80 33.0 % ex vivo light microscopy with histochemistry 0.0 0 107917 3099
SHRSP/A3NCrl percentage of study population developing cerebral small perivascular bleeds and beta-amyloid deposits during a period of time control condition Pirici D, etal., Brain Pathol. 2017 Mar;27(2):169-180. doi: 10.1111/bpa.12384. Epub 2016 May 30. cerebral cortex integrity trait male 84 days-308 days 18 56.0 % ex vivo light microscopy with histochemistry 0.0 0 107921 3099
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 8 3.3 / 100 um 2.8 7.92 ex vivo light microscopy with histochemistry 0.0 0 109122 3082
BDIX/OrlCrl small liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.8 mm 0.18 0.4 ex vivo light microscopy with histochemistry 0.0 30 days group A 111077 3195
BDIX/OrlCrl small liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (3 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 1.8 mm 0.45 1.0 ex vivo light microscopy with histochemistry 0.0 30 days group C 111079 3195
BDIX/OrlCrl number of large metastatic liver tumors DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group A 111158 3195
BDIX/OrlCrl number of large metastatic liver tumors DHD/K12/TRb cells (2 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group B 111159 3195
BDIX/OrlCrl number of large metastatic liver tumors in the left liver DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (0.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 1.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 1 111173 3195
BDIX/OrlCrl number of large metastatic liver tumors in the left liver DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 1.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 3 111175 3195
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then isolated lung perfusion with Hespan buffer (1 ml/min) (for 0.3 hours) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 4 503.0 null 17.0 34.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 2 111182 3197
WKY/N kidney tubule regeneration foci count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 0.25 /section 0.25 ex vivo light microscopy with histochemistry 0.0 0 107545 3090
SHRSP/A3N kidney tubule regeneration foci count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 1.3 /section 0.3 ex vivo light microscopy with histochemistry 0.0 0 107546 3090
BDIX/OrlCrl number of small metastatic liver tumors DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 12.0 null 0.89 2.0 ex vivo light microscopy with histochemistry 0.0 30 days group A 111058 3195
BDIX/OrlCrl number of large metastatic liver tumors in the left liver DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 1.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 2 111174 3195
SS/NEisSlc neuron count controlled cilazapril content drinking water (0.16 mg/kg/d) (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. hippocampus neuron quantity not specified 547 days 10 1466.0 cells/mm2 42.0 132.82 ex vivo light microscopy with histochemistry 0.0 0 107466 2339
SHRSP/A3N kidney total tubule cast count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 350.0 /section 80.0 ex vivo light microscopy with histochemistry 0.0 0 total tubular casts 107493 3088
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 11 12.6 x 10E3 um2 3.8 12.6 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107460 2378
BDIX/OrlCrl number of small metastatic liver tumors DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 10.0 null 0.45 1.0 ex vivo light microscopy with histochemistry 0.0 30 days group 3 111063 3195
LEH/Hkv percentage of study population developing colonic aganglionosis during a period of time specific pathogen-free condition Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7. colorectal integrity trait male 14 days 12 100.0 % ex vivo light microscopy with histochemistry 0.0 0 102830 2741
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 7 4.7 % 1.97 5.2 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101605 2602
ACI.FHH-(D1Rat324-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 8 41.0 % 9.0 25.46 ex vivo light microscopy with histochemistry 0.0 0 % glomerulosclerosis 67961 751
F344.AR-EdnrbslHkv percentage of study population developing colonic aganglionosis during a period of time specific pathogen-free condition Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7. colorectal integrity trait male 14 days 32 53.0 % ex vivo light microscopy with histochemistry 0.0 0 102832 2741
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count AMG-8718 (100 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81 days-88 days 5 11.7 null 0.31 0.7 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105452 3016
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 3.3 / 100 um 2.8 6.26 ex vivo light microscopy with histochemistry 0.0 0 contralateral control eye 107362 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 2.4 / 100 um 3.2 7.16 ex vivo light microscopy with histochemistry 0.0 0 contralateral control eye 107364 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (67.5 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 30.8 / 100 um 14.3 31.98 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107365 3082
SS/NEisSlc neuron count vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. hippocampus neuron quantity not specified 547 days 10 1258.0 cells/mm2 32.0 101.19 ex vivo light microscopy with histochemistry 0.0 0 107465 2339
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 11.1 x 10E3 um2 2.8 11.2 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107513 2378
WKY/N kidney glomerular lesion count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney glomerulus integrity trait male 126 days-182 days 0 0.8 /section 0.5 ex vivo light microscopy with histochemistry renal glomerulus 0.0 0 107537 3090
SHRSP/A3N kidney total tubule cast count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 349.0 /section 45.0 ex vivo light microscopy with histochemistry 0.0 0 107555 3090
SHRSP/A3N kidney total tubule cast count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 4.0 /section 3.0 ex vivo light microscopy with histochemistry 0.0 0 107556 3090
SHRSP/A3N renal fibrosis foci count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 7.4 /section 0.4 ex vivo light microscopy with histochemistry 0.0 0 107558 3090
SHRSP/A3N renal fibrosis foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 16.4 /section 1.4 ex vivo light microscopy with histochemistry 0.0 0 107559 3090
SHRSP/A3N renal fibrosis foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 7.1 /section 0.3 ex vivo light microscopy with histochemistry 0.0 0 107560 3090
LEW/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 20 days 5 60.7 um 1.34 3.0 ex vivo light microscopy with histochemistry 0.0 0 109362 3137
LEW/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 45 days 5 102.8 um 1.92 4.3 ex vivo light microscopy with histochemistry 0.0 0 109363 3137
LEW/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 60 days 5 115.3 um 2.19 4.9 ex vivo light microscopy with histochemistry 0.0 0 109364 3137
LEW/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 150 days 5 131.4 um 2.24 5.0 ex vivo light microscopy with histochemistry 0.0 0 109366 3137
GK capillary number to soleus muscle fiber number ratio control condition Kondo H, etal., Muscle Nerve. 2015 Mar;51(3):391-9. doi: 10.1002/mus.24316. Epub 2015 Jan 6. skeletal muscle capillary amount male 63 days 6 2.0 null 0.04 0.1 ex vivo light microscopy with histochemistry 0.0 0 108121 3110
W/Kyo capillary number to soleus muscle fiber number ratio control condition Kondo H, etal., Muscle Nerve. 2015 Mar;51(3):391-9. doi: 10.1002/mus.24316. Epub 2015 Jan 6. skeletal muscle capillary amount male 63 days 6 1.85 null 0.11 0.27 ex vivo light microscopy with histochemistry 0.0 0 108119 3110
MWF/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 60 days 5 2.63 mm 0.05 0.11 ex vivo light microscopy with histochemistry 0.0 0 109334 3137
LEW/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 10 days 5 0.65 mm 0.02 0.05 ex vivo light microscopy with histochemistry 0.0 0 109337 3137
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio subthreshold laser therapy (200 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 8 3.0 / 100 um 2.5 7.07 ex vivo light microscopy with histochemistry 0.0 SRT 161 days experimental eye 109067 3082
BDIX/OrlCrl small liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.8 mm 0.18 0.4 ex vivo light microscopy with histochemistry 0.0 30 days group 3 111082 3195
BDIX/OrlCrl number of large metastatic liver tumors DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 1.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 2 111162 3195
BDIX/OrlCrl number of large metastatic liver tumors in the right liver DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group A 111164 3195
BDIX/OrlCrl number of large metastatic liver tumors in the right liver DHD/K12/TRb cells (3 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group C 111166 3195
BDIX/OrlCrl number of large metastatic liver tumors in the right liver DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (0.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 1 111167 3195
BDIX/OrlCrl number of large metastatic liver tumors in the left liver DHD/K12/TRb cells (3 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group C 111172 3195
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 11.8 x 10E3 um2 2.9 11.96 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107512 2378
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 11.7 x 10E3 um2 2.9 11.6 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107514 2378
SHRSP/A3N kidney tubule regeneration foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 0.0 /section 0.0 ex vivo light microscopy with histochemistry 0.0 0 107548 3090
BDIX/OrlCrl large liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (0.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 7.9 mm 0.45 1.0 ex vivo light microscopy with histochemistry 0.0 30 days group 1 111083 3195
SHRSP/A3N kidney tubule regeneration foci count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 5.8 /section 1.8 ex vivo light microscopy with histochemistry 0.0 0 foci of tubular regeneration 107484 3088
SHRSP/A3N kidney total tubule cast count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 72.0 /section 18.0 ex vivo light microscopy with histochemistry 0.0 0 total tubular casts 107492 3088
SHRSP/A3N kidney total tubule cast count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 21.0 /section 11.0 ex vivo light microscopy with histochemistry 0.0 0 total tubular casts 107494 3088
SHRSP/A3N renal fibrosis foci count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 20.0 /section 2.0 ex vivo light microscopy with histochemistry 0.0 0 foci of renal fibrosis 107496 3088
SHRSP/A3N renal fibrosis foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 25.0 /section 1.0 ex vivo light microscopy with histochemistry 0.0 0 foci of renal fibrosis 107497 3088
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then isolated lung perfusion with floxuridine (3.5 mg/ml) (for 0.3 hours) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 5 541.0 null 39.35 88.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 3 111178 3197
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then isolated lung perfusion with floxuridine (7 mg/ml) (for 0.3 hours) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 7 169.0 null 13.23 35.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 4 111184 3197
BDIX/OrlCrl number of large metastatic liver tumors in the right liver DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 3 111169 3195
ACI.FHH-(D1Rat324-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 98 days 18 10.0 % 1.0 4.24 ex vivo light microscopy with histochemistry 0.0 0 68047 751
F344.AR-EdnrbslHkv percentage of study population developing colonic aganglionosis during a period of time specific pathogen-free condition Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7. colorectal integrity trait female 14 days 21 38.0 % ex vivo light microscopy with histochemistry 0.0 0 102833 2741
BDIX/OrlCrl number of small metastatic liver tumors phosphate buffered saline (0.2 ml) then phosphate buffered saline (0.1 ml) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 3 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days sham surgical group 111057 3195
SS/NEisSlc number of nucleated cells per kidney glomerulus controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. kidney glomerulus morphology trait male 91 days 6 50.4 null 1.25 3.06 ex vivo light microscopy with histochemistry 0.0 0 100730 2519
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio controlled NG-nitroarginine methyl ester content in acidified drinking water (8-13 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 9 5.0 % 6.0 18.0 ex vivo light microscopy with histochemistry 0.0 0 67954 751
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 98 days 15 5.0 % 1.0 3.87 ex vivo light microscopy with histochemistry 0.0 0 68045 751
LEH/Hkv percentage of study population developing colonic aganglionosis during a period of time specific pathogen-free condition Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7. colorectal integrity trait female 14 days 15 100.0 % ex vivo light microscopy with histochemistry 0.0 0 102831 2741
MWF/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 10 days 5 52.7 um 1.25 2.8 ex vivo light microscopy with histochemistry 0.0 0 109355 3137
MWF/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 60 days 5 129.8 um 2.86 6.4 ex vivo light microscopy with histochemistry 0.0 0 109358 3137
MWF/Ztm kidney glomerulus diameter control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney glomerulus size trait male 100 days 5 131.9 um 2.24 5.0 ex vivo light microscopy with histochemistry 0.0 0 109359 3137
GK capillary number to soleus muscle fiber number ratio running on treadmill (15 m/min) (for 1 hours) Kondo H, etal., Muscle Nerve. 2015 Mar;51(3):391-9. doi: 10.1002/mus.24316. Epub 2015 Jan 6. skeletal muscle capillary amount male 63 days 6 1.98 null 0.16 0.39 ex vivo light microscopy with histochemistry 0.0 0 108122 3110
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (22.5 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 17.2 / 100 um 5.4 12.07 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107361 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 3.4 / 100 um 3.7 8.27 ex vivo light microscopy with histochemistry 0.0 0 contralateral control eye 107366 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio laser photocoagulation (135 um) (for 0 hours) Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 3.1 / 100 um 2.3 5.14 ex vivo light microscopy with histochemistry 0.0 photocoagulation 161 days experimental eye 107367 3082
RCS-p+/LavRrrc retinal outer nuclear layer photoreceptor nucleus count to layer length ratio control condition Kang S, et al., Transl Vis Sci Technol. 2019 Aug 7;8(4):19. doi: 10.1167/tvst.8.4.19. eCollection 2019 Jul. retinal photoreceptor quantity not specified 180 days 5 3.5 / 100 um 3.0 6.71 ex vivo light microscopy with histochemistry 0.0 0 contralateral control eye 107370 3082
WKY/N renal fibrosis foci count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 5.9 /section 0.7 ex vivo light microscopy with histochemistry 0.0 0 107557 3090
LEW/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 60 days 5 2.73 mm 0.06 0.13 ex vivo light microscopy with histochemistry 0.0 0 109340 3137
LEW/Ztm renal cortex thickness control condition Hackbarth H, etal., Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882. kidney cortex morphology trait male 150 days 5 2.96 mm 0.09 0.2 ex vivo light microscopy with histochemistry 0.0 0 109342 3137
WKY/N kidney glomerular lesion count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney glomerulus integrity trait male 210 days-224 days 0 0.5 /section 0.4 ex vivo light microscopy with histochemistry 0.0 0 107475 3088
SHRSP/A3N kidney glomerular lesion count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney glomerulus integrity trait male 210 days-224 days 0 31.0 /section 5.0 ex vivo light microscopy with histochemistry 0.0 0 107477 3088
SHRSP/A3NCrl percentage of study population developing renal vascular pathology during a period of time control condition Pirici D, etal., Brain Pathol. 2017 Mar;27(2):169-180. doi: 10.1111/bpa.12384. Epub 2016 May 30. kidney integrity trait male 168 days-308 days 80 45.0 % ex vivo light microscopy with histochemistry 0.0 0 107920 3099
BDIX/OrlCrl number of large metastatic liver tumors in the right liver DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with histochemistry 0.0 30 days group 2 111168 3195
MWF/Ztm kidney sclerotic glomeruli count to total glomeruli count ratio standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. kidney glomerulus integrity trait male 210 days 10 median 18.6 % ex vivo light microscopy with histochemistry left kidney 0.0 0 109986 3162
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then isolated lung perfusion with floxuridine (7 mg/ml) (for 0.3 hours) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 7 490.0 null 34.39 91.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 4 111179 3197
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then isolated lung perfusion with floxuridine (14 mg/ml) (for 0.3 hours) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 7 455.0 null 32.88 87.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 5 111180 3197
BDIX/HanHsd metastatic lung tumor number DHD/K12/TRb - Sp-5 cells (1 X 10E6) then floxuridine (1 mg/kg/d) (for 7 days) Ng B, etal., Ann Thorac Surg. 1995 Jan;59(1):205-8. doi: 10.1016/0003-4975(94)00774-2. lung integrity trait female 0 days 5 216.0 null 41.59 93.0 ex vivo light microscopy with histochemistry 0.0 26 days India ink stain; tissue stains, tumors white Group 1 111181 3197
SHRSP/A3N kidney tubule regeneration foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 27.3 /section 2.9 ex vivo light microscopy with histochemistry 0.0 0 107547 3090
SHRSP/A3N interstitial nephritis foci count control condition Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 4.9 /section 1.0 ex vivo light microscopy with histochemistry 0.0 0 107550 3090
SHRSP/A3N interstitial nephritis foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 1.0 /section 0.4 ex vivo light microscopy with histochemistry 0.0 0 107552 3090
BDIX/OrlCrl large liver metastatic tumorous lesion diameter measurement DHD/K12/TRb cells (1 X 10E6) and DHD/K12/TRb cells (1.5 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 17.7 mm 0.36 0.8 ex vivo light microscopy with histochemistry 0.0 30 days group 3 111085 3195
SHRSP/A3N kidney tubule regeneration foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 1.9 /section 1.3 ex vivo light microscopy with histochemistry 0.0 0 foci of tubular regeneration 107486 3088
SHRSP/A3N interstitial nephritis foci count control condition Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 3.1 /section 0.7 ex vivo light microscopy with histochemistry 0.0 0 foci of interstitial nephritis 107488 3088
SHRSP/A3N interstitial nephritis foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 6.6 /section 2.3 ex vivo light microscopy with histochemistry 0.0 0 foci of interstitial nephritis 107489 3088
SHRSP/A3N renal fibrosis foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 15.0 /section 2.0 ex vivo light microscopy with histochemistry 0.0 0 foci of renal fibrosis 107498 3088
BDIX/OrlCrl number of small metastatic liver tumors DHD/K12/TRb cells (3 X 10E6) Maggiori L, etal., Int J Exp Pathol. 2012 Dec;93(6):414-20. doi: 10.1111/j.1365-2613.2012.00841.x. liver integrity trait male 0 days 5 22.0 null 0.89 2.0 ex vivo light microscopy with histochemistry 0.0 30 days group C 111060 3195
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 17.0 x 10E3 um2 4.1 16.9 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107462 2378
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 8 26.0 % 3.89 11.0 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101630 2602