Phenominer Database Results (717 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Sample Notes Experiment Notes Record ID Study ID
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.33 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51808 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 5 8.51 ng/ml/h 2.42 5.42 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51832 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 3 0.84 ng/ml/h 0.08 0.14 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51836 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 6 1.23 ng/ml/h 0.27 0.66 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51838 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 0.65 ng/ml/h 0.25 0.6 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51841 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 9 0.22 mg/dl 0.01 0.03 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51898 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51896 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.31 mg/dl 0.02 0.04 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51902 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.3 mg/dl 0.01 0.02 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51904 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.27 mg/dl 0.0 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52037 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.35 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52038 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.27 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52046 481
FHH-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 1 1.17 ng/ml/h radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52883 482
FHH-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 0.4 ng/ml/h 0.07 0.16 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52885 482
FHH-Chr 5BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 1.16 ng/ml/h 0.33 0.88 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52890 482
FHH-Chr XBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 6 2.25 ng/ml/h 0.51 1.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52913 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 1.61 ng/ml/h 0.88 2.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52919 482
FHH-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 2.48 ng/ml/h 0.69 1.38 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52921 482
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.33 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52223 482
SS-Chr 4BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.34 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52225 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 15 0.35 mg/dl 0.02 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52236 482
FHH-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52244 482
LE/BluGill plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 9 0.33 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52239 482
FHH-Chr 5BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.32 mg/dl 0.03 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52249 482
FHH-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.24 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52258 482
FHH-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 6 0.49 mg/dl 0.1 0.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52271 482
FHH-Chr 17BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.61 mg/dl 0.09 0.21 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52274 482
FHH-Chr 4BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.4 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52276 482
FHH-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 3 0.31 mg/dl 0.05 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52277 482
FHH-Chr 10BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.46 mg/dl 0.04 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52282 482
FHH-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.39 mg/dl 0.05 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52286 482
FHH-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.43 mg/dl 0.04 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52288 482
FHH-Chr 7BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.51 mg/dl 0.05 0.14 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52287 482
FHH-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 73.05 mg/d 23.6 70.81 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52387 482
FHH-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 24.31 mg/d 6.0 15.88 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52393 482
FHH-Chr 19BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 31.83 mg/d 11.92 33.71 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52396 482
FHH-Chr XBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 204.89 mg/d 18.57 49.14 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52421 482
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 0.29 ng/ml/h 0.04 0.13 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52439 482
SS-Chr 10BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 3.82 ng/ml/h 0.85 2.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52444 482
SS-Chr 5BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 0.44 ng/ml/h 0.08 0.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52448 482
SS-Chr 7BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.51 ng/ml/h 0.12 0.37 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52446 482
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 1.66 ng/ml/h 0.38 1.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52451 482
SS-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 0.42 ng/ml/h 0.07 0.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52455 482
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.75 ng/ml/h 0.15 0.45 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52464 482
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 55 0.68 ng/ml/h 0.12 0.9 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52465 482
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 1.04 ng/ml/h 0.18 0.51 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52468 482
SS-Chr 1BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 14 0.67 ng/ml/h 0.2 0.76 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52469 482
SS-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 10 0.99 ng/ml/h 0.13 0.43 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52477 482
SS-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 0.88 ng/ml/h 0.15 0.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52479 482
SS-Chr 10BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 11 85.48 mg/d 21.9 72.63 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52580 482
SS-Chr 5BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 11.82 mg/d 2.27 6.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52593 482
SS-Chr 9BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 24.49 mg/d 5.25 15.74 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52587 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 16 10.59 mg/d 2.08 8.32 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52606 482
SS-Chr XBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 49.97 mg/d 10.84 28.67 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52612 482
SS.BN-(D8Rat163-D8Rat81)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 13 9.97 mg/d 1.58 5.68 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52617 482
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 6 7.97 ng/ml/h 1.02 2.5 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50541 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 2 1.95 ng/ml/h 0.95 1.34 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50566 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 6 2.26 ng/ml/h 0.6 1.47 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50570 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 9 0.32 mg/dl 0.01 0.04 radioimmunoassay 0 50690 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 9 0.76 ng/ml/h 0.14 0.41 radioimmunoassay 0 50712 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51173 481
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 11 0.32 mg/dl 0.03 0.11 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51277 481
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 11 0.32 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51311 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 3 0.3 mg/dl 0.02 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51322 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 8 2.16 ng/ml/h 0.24 0.68 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51606 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.26 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51647 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 10 0.33 mg/dl 0.03 0.08 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51646 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.31 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51650 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 9 0.4 mg/dl 0.02 0.06 radioimmunoassay 0 50409 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 14 0.93 ng/ml/h 0.15 0.56 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50456 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 7 0.83 ng/ml/h 0.23 0.6 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50464 481
F344/NHsd plasma corticosterone level control condition Solberg LC, et al., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8 blood corticosterone amount male 105 days 28 81.0 ng/ml 8.3 43.92 radioimmunoassay 0 13120 105
DA.F344-(D4Uia2-D4Wox21)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 9 182.15 ng/ml 15.49 46.48 radioimmunoassay 0.0 0 68646 970
BN/Cub serum insulin level fasting (for 16 hours) Seda O, et al., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22. blood insulin amount male 300 days 6 0.01 mg/dl 0.0 0.0 radioimmunoassay retroorbital plexus 0.0 0 70275 1318
BN/Cub serum insulin level controlled sucrose content diet (for 7 days) then dexamethasone (0.03 mg/ml) (for 3 days) then fasting (for 16 hours) Seda O, et al., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22. blood insulin amount male 310 days 6 0.08 mg/dl 0.02 0.04 radioimmunoassay retroorbital plexus 0.0 0 70279 1318
PD/Cub serum insulin level controlled sucrose content diet (for 7 days) then dexamethasone (0.03 mg/ml) (for 3 days) then fasting (for 16 hours) Seda O, et al., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22. blood insulin amount male 310 days 6 0.12 mg/dl 0.0 0.01 radioimmunoassay retroorbital plexus 0.0 0 70278 1318
WKY/NHsd serum thyroid stimulating hormone level control condition Baum AE, et al., Endocrinology 2004 Oct 28;. blood thyroid-stimulating hormone amount female 70 days-0 days 15 3.0 ng/ml 0.05 0.21 radioimmunoassay 0.0 0 serum tsh 67898 252
BB/OK serum leptin level control condition Kloting N, et al., Obes Res 2005 Mar;13(3):589-95. blood leptin amount male 224 days 20 7.7 ng/ml 1.7 7.6 radioimmunoassay 0.0 0 67940 227
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) and controlled tempol content drinking water (0.5 mmol/l) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 42 days 4 157.3 pg/ml 45.2 90.4 radioimmunoassay 0.0 0 69654 736
DA/K serum leptin level control condition Kovacs P, et al., Biochem Biophys Res Commun 2000 Mar 24;269(3):660-5. blood leptin amount not specified 196 days-224 days 12 2.61 ng/ml 0.22 0.76 radioimmunoassay 0.0 0 96845 1123
Crl:CD(SD) serum progesterone level maternal milk (for 20 days) and bisphenol A (250 ug/kg) (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood progesterone amount female 50 days 24 9.9 ng/ml 1.9 9.31 radioimmunoassay 0.0 0 76263 1558
WAG/Nov plasma corticosterone level physical restraint in tube type rodent restrainer (for 0.5 hours) Redina OE, et al., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502. blood corticosterone amount male 180 days 13 310.0 ng/ml 7.9 28.48 radioimmunoassay 0.0 0 97063 1818
SR/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 7.6 pg/ml 0.7 1.71 radioimmunoassay 0.0 ovx 63 days 102362 2686
GK/MolTac plasma renin activity level control condition Korkmaz-Ic�z S, et al., Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H958-H971. doi: 10.1152/ajpheart.00956.2015. Epub 2016 Aug 12. renin activity male 112 days 8 4.8 ng/ml/h 1.9 5.37 radioimmunoassay 0.0 0 102947 2783
WKY plasma aldosterone level controlled in utero environment (30 % of calories) (for 22 days) Riviere G, et al., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3. blood aldosterone amount male 112 days 6 1130.0 pg/ml 240.0 587.88 radioimmunoassay 0.0 0 101692 2218
BN-Chr 13LH/MavRrrc plasma insulin level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 9 23.41 mU/l 1.88 5.64 radioimmunoassay 0.0 0 102095 2645
BN/NHsdMcwi plasma insulin level to plasma glucose level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 10 2.76 mU/mmol 0.13 0.41 radioimmunoassay 0.0 0 mU/mmol plasma insulin level to plasma glucose level ratio (CMO:0003555) 102096 2645
LH/Mav plasma insulin level to plasma glucose level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 10 3.8 mU/mmol 0.25 0.79 radioimmunoassay 0.0 0 mU/mmol plasma insulin level to plasma glucose level ratio (CMO:0003555) 102097 2645
SHR/NCrlCrlj plasma angiotensin II level to plasma angiotensin I level ratio unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 5 0.8 null 0.13 0.29 radioimmunoassay 0.0 unx 42 days blood ang II level 101278 2583
SHR/NCrlCrlj plasma angiotensin II level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 5 11.6 pg/ml 2.1 4.7 radioimmunoassay 0.0 unx 42 days blood ang II level 101274 2583
SD plasma renin activity level unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. renin activity male 0 days 11 4.3 ng/ml/h 0.63 2.08 radioimmunoassay 0.0 unx 13 days - 101564 2602
SR/JrHsd serum vasopressin level gelled diet (200 g/kg/d) (for 8 days) then distilled water (for 6 days) Fenton RA, et al., Am J Physiol Renal Physiol. 2003 Jul;285(1):F143-51. Epub 2003 Apr 8. blood antidiuretic hormone amount male 0 days 6 2.49 pmol/l 0.1 0.24 radioimmunoassay 0.0 osmotic pump implant 6 days 102588 2691
WKY blood glucose level streptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 533.7 mg/dl 25.56 80.83 radioimmunoassay 0.0 0 99103 2219
SHR/NCrlCrlj plasma angiotensin II level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 5 16.0 pg/ml 3.0 6.71 radioimmunoassay 0.0 unx 42 days blood ang II level 101277 2583
SR/Hsd plasma urotensin II level standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. blood urotensin II amount male 49 days 8 61.0 pg/ml 2.09 5.9 radioimmunoassay 0.0 0 102275 2683
SR/NEisSlc kidney cortical adrenomedullin level controlled sodium chloride content diet (8 %) (for 7 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 63 days 7 0.59 fmol/mg 0.04 0.1 radioimmunoassay 0.0 0 102441 2689
SR/NEisSlc kidney cortical adrenomedullin level controlled sodium chloride content diet (8 %) (for 21 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 77 days 7 0.55 fmol/mg 0.02 0.06 radioimmunoassay 0.0 0 102445 2689
SD heart left ventricle interstitial angiotensin II level during a period of time sham surgical control condition (for 105 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. heart left ventricle interstitial angiotensin II amount male 175 days 8 1.6 pg/hr 0.2 0.57 radioimmunoassay 0.0 sham ACF 105 days heart left ventricle interstitial angiotensin II level during a period of time 99261 2278
SD plasma angiotensin II level artificial aortocaval fistula (for 105 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. blood angiotensin II amount male 175 days 10 65.0 pg/ml 13.0 41.11 radioimmunoassay 0.0 ACF 105 days 99278 2278
SD plasma bradykinin level sham surgical control condition (for 28 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. blood bradykinin amount male 98 days 8 10.0 pg/ml 1.0 2.83 radioimmunoassay 0.0 sham ACF 28 days pl bk 99279 2278
SS/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 117.0 fmol/mg 7.3 radioimmunoassay 0.0 0 102229 2681
SS/NEisSlc urine aldosterone excretion rate controlled sodium content diet (8 %) (for 49 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. urine aldosterone amount male 49 days 30 13.84 ng/d 1.27 6.96 radioimmunoassay 0.0 0 ng/d 100692 2519
SD serum testosterone level in utero condition (for 7 days) and dibutyl phthalate (850 mg/kg/d) (for 7 days) Jiang JT, et al., Toxicology. 2015 Dec 2;338:77-85. doi: 10.1016/j.tox.2015.10.006. Epub 2015 Oct 26. blood testosterone amount male 1 days 6 0.4 ng/ml 0.05 0.13 radioimmunoassay 1.0 0 98731 2158
MNS plasma vasopressin level control condition Capasso G, et al., Am J Physiol Renal Physiol. 2005 Jun;288(6):F1173-82. doi: 10.1152/ajprenal.00228.2004. Epub 2005 Feb 1. blood antidiuretic hormone amount not specified 23 days-25 days 11 9.9 pg/ml 1.9 6.3 radioimmunoassay 0.0 0 104164 2926
MHS plasma vasopressin level control condition Capasso G, et al., Am J Physiol Renal Physiol. 2005 Jun;288(6):F1173-82. doi: 10.1152/ajprenal.00228.2004. Epub 2005 Feb 1. blood antidiuretic hormone amount not specified 23 days-25 days 11 10.4 pg/ml 3.2 10.61 radioimmunoassay 0.0 0 104165 2926
SHRSP/A3N plasma aldosterone level controlled sodium content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. blood aldosterone amount male 182 days-210 days 8 347.0 pg/ml 72.0 203.65 radioimmunoassay 0.0 0 107938 3100
GK pancreatic islet insulin level control condition Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreas molecular composition trait female 73 days 2 1.13 mU/islet 0.15 0.21 radioimmunoassay 0.0 0 110625 3179
GK pancreatic islet insulin level controlled dehydroepiandrosterone content diet (0.2 %) (for 28 days) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreas molecular composition trait male 73 days 2 0.57 mU/islet 0.25 0.35 radioimmunoassay 0.0 0 110624 3179
GK pancreatic islet insulin release measurement controlled dehydroepiandrosterone content diet (0.2 %) (for 28 days) then glucose solution (2.8 mmol/l) (for 1.5 hours) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreatic beta cell physiology trait male 73 days 33 18.3 uU/islet/90min 1.9 10.91 radioimmunoassay 0.0 glucose 90 min ex vivo incubation 110628 3179
GK pancreatic islet insulin release measurement controlled dehydroepiandrosterone content diet (0.2 %) (for 28 days) then glucose solution (2.8 mmol/l) (for 1.5 hours) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreatic beta cell physiology trait female 73 days 33 12.9 uU/islet/90min 2.6 14.94 radioimmunoassay 0.0 glucose 90 min ex vivo incubation 110630 3179
SHRSP/A3N plasma aldosterone level control condition Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. blood aldosterone amount male 182 days-210 days 8 178.0 pg/ml 12.0 33.94 radioimmunoassay 0.0 0 107937 3100
MWF plasma direct renin activity level control condition Schie�l IM, etal., J Pharmacol Exp Ther. 2015 May;353(2):299-306. doi: 10.1124/jpet.114.222125. Epub 2015 Feb 13. renin activity male 63 days 7 5.4 ng AI/ml/h 1.2 3.17 radioimmunoassay tail 0.0 0 108051 3113
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 0.3 ng/ml/h 0.03 0.07 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50535 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 5 1.57 ng/ml/h 0.07 0.16 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50538 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51315 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.27 mg/dl 0.01 0.02 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51535 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.3 mg/dl 0.06 0.15 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51538 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 3.34 ng/ml/h 0.14 0.39 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50393 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 7 15.17 ng/ml/h 1.06 2.81 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50414 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 7 1.67 ng/ml/h 0.24 0.62 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50463 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.33 mg/dl 0.02 0.04 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51897 481
F344/NHsd plasma corticosterone level physical restraint (for 0.2 hours) Solberg LC, et al., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8 blood corticosterone amount male 105 days 28 354.7 ng/ml 18.9 100.01 radioimmunoassay 0.0 0 13126 105
FHH-Chr 1BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 9 3.7 ng/ml/h 0.8 2.4 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52924 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.38 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52191 482
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.4 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52197 482
SS-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.34 mg/dl 0.03 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52213 482
SS-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.45 mg/dl 0.04 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52210 482
SS-Chr 1BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 13 0.32 mg/dl 0.02 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52224 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.41 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52235 482
FHH-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 2 100.4 mg/d 43.43 61.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52391 482
FHH-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 6 66.49 mg/d 34.22 83.82 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52394 482
FHH-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 6 70.1 mg/d 24.53 60.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52422 482
SS-Chr 6BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 11.6 mg/d 4.48 14.16 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52583 482
SS-Chr 16BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 4.75 mg/d 0.73 2.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52597 482
LOU/NimrOlaHsd plasma insulin-like growth factor 1 level controlled calorie content diet (2.9 kcal/g) (between 28 and 126 days) then fasting (for 16 hours) Marissal-Arvy N, et al., Growth Horm IGF Res. 2013 Dec;23(6):220-8. doi: 10.1016/j.ghir.2013.08.002. Epub 2013 Aug 19. blood insulin-like growth factor amount female 126 days 0 675.0 ng/ml 31.0 radioimmunoassay 0.0 0 84692 1598
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) (for 28 days) then controlled sodium content diet (0.3 %) (for 28 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 98 days 4 295.0 pg/ml 54.3 108.6 radioimmunoassay 0.0 0 69657 736
DA.F344-(D4Got44-D4Arb21)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 7 126.36 ng/ml 19.73 52.19 radioimmunoassay 0.0 0 68643 970
LEW/OlaHsd serum aldosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood aldosterone amount male 49 days-77 days 6 0.8 nmol/l 0.13 0.31 radioimmunoassay 0.0 0 68625 271
BC/CpbU serum aldosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood aldosterone amount male 49 days-77 days 6 1.38 nmol/l 0.18 0.44 radioimmunoassay 0.0 0 68623 271
BC/CpbU serum corticosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood corticosterone amount male 49 days-77 days 6 184.0 nmol/l 89.41 219.0 radioimmunoassay 0.0 0 68627 271
SS/NEisSlc plasma renin activity level controlled sodium content diet (0.3 %) (for 91 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. renin activity male 91 days 6 2.49 ng/ml/h 0.63 1.53 radioimmunoassay 0.0 0 100688 2519
ISIAH plasma corticosterone level control condition Redina OE, et al., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502. blood corticosterone amount male 180 days 10 54.0 ng/ml 16.0 50.6 radioimmunoassay 0.0 0 97060 1818
WAG/Nov plasma corticosterone level control condition Redina OE, et al., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502. blood corticosterone amount male 180 days 13 14.0 ng/ml 3.0 10.82 radioimmunoassay 0.0 0 97062 1818
SD plasma renin activity level sham surgical control condition (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. renin activity male 0 days 6 3.1 ng/ml/h 0.29 0.7 radioimmunoassay 0.0 sham unx 13 days 101563 2602
M520/NRrrcMcwi blood triiodothyronine amount controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount male 91 days 9 68.92 µg/dL 5.29 15.88 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from M to male to standardize across records, 7-30-2024 139813 3292
M520/NRrrcMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount female 91 days 8 75.74 µg/dL 2.68 7.57 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from F to female to standardize across records, 7-30-2024 139684 3292
BUF/MnaMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount female 91 days 9 104.53 µg/dL 4.84 14.52 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from F to female to standardize across records, 7-30-2024 139168 3292
ACI/EurMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount female 91 days 8 68.84 µg/dL 2.36 6.67 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from F to female to standardize across records, 7-30-2024 138674 3292
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 5 1.48 ng/ml/h 0.33 0.74 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51845 481
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 10 0.58 ng/ml/h 0.14 0.43 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51842 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 3 2.06 ng/ml/h 0.69 1.19 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51844 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 2 0.27 mg/dl 0.04 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52043 481
FHH-Chr 15BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 2.92 ng/ml/h 0.71 2.13 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52879 482
FHH-Chr 19BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 4.98 ng/ml/h 0.69 1.82 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52888 482
FHH-Chr 6BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 6 3.2 ng/ml/h 0.43 1.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52889 482
FHH-Chr 13BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 8.07 ng/ml/h 0.72 1.91 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52892 482
FHH-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 4.81 ng/ml/h 0.78 2.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52895 482
FHH-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 10.07 ng/ml/h 1.37 3.87 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52898 482
FHH-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 6.16 ng/ml/h 1.63 4.32 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52906 482
FHH-Chr 4BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 4.38 ng/ml/h 1.19 2.38 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52908 482
FHH-Chr 4BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 11.17 ng/ml/h 2.91 8.22 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52911 482
FHH-Chr 10BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 1.23 ng/ml/h 0.39 0.78 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52917 482
FHH-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 4.85 ng/ml/h 1.02 2.7 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52923 482
SS-Chr 10BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 10 0.37 mg/dl 0.04 0.11 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52190 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.34 mg/dl 0.04 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52195 482
SS-Chr YBN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 12 0.31 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52218 482
SS-Chr 4BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.29 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52231 482
SS-Chr 12BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 3 0.27 mg/dl 0.02 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52234 482
SS.BN-(D8Rat163-D8Rat81)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 18 0.34 mg/dl 0.02 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52233 482
FHH-Chr 19BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.39 mg/dl 0.06 0.14 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52247 482
FHH-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.24 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52250 482
FHH-Chr 13BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.29 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52257 482
FHH-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.43 mg/dl 0.05 0.14 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52260 482
FHH-Chr 14BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.43 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52267 482
FHH-Chr 10BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.34 mg/dl 0.05 0.12 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52270 482
FHH-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 3 0.5 mg/dl 0.2 0.34 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52280 482
FHH-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.4 mg/dl 0.07 0.16 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52279 482
FHH-Chr 7BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.34 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52281 482
FHH-Chr 5BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 6 42.75 mg/d 11.47 28.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52392 482
FHH-Chr 8BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 4 144.63 mg/d 56.92 113.84 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52399 482
FHH-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 5 117.94 mg/d 38.55 86.21 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52412 482
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 48 183.29 mg/d 13.89 96.23 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52407 482
FHH-Chr 17BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 151.8 mg/d 21.71 68.65 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52417 482
FHH-Chr 17BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 15 81.65 mg/d 11.38 44.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52418 482
FHH-Chr 9BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 5 134.79 mg/d 42.57 95.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52423 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 8 5.41 mg/d 1.01 2.85 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52426 482
FHH-Chr 1BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 9.79 mg/d 2.7 8.53 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52432 482
FHH-Chr XBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 54.12 mg/d 21.95 58.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52428 482
SS-Chr 10BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 10 0.93 ng/ml/h 0.12 0.39 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52435 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 1.01 ng/ml/h 0.34 0.95 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52440 482
SS-Chr 6BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 1.2 ng/ml/h 0.42 1.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52443 482
SS-Chr 17BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 0.36 ng/ml/h 0.08 0.22 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52445 482
SS-Chr 5BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 6 0.68 ng/ml/h 0.33 0.8 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52450 482
SS-Chr 7BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 11 1.31 ng/ml/h 0.26 0.87 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52449 482
SS-Chr 1BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 16 0.49 ng/ml/h 0.07 0.29 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52466 482
SS.BN-(D8Rat163-D8Rat81)/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 10 1.79 ng/ml/h 0.42 1.31 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52472 482
SS-Chr 19BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 0.66 ng/ml/h 0.09 0.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52475 482
SS-Chr 4BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 1.23 ng/ml/h 0.24 0.64 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52476 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 15 4.4 ng/ml/h 1.26 4.87 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52481 482
SS-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.58 ng/ml/h 0.1 0.29 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52483 482
SS-Chr 6BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 26.28 mg/d 5.67 17.01 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52588 482
SS-Chr 20BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 22.06 mg/d 2.46 7.38 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52596 482
SS-Chr 17BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 131.37 mg/d 26.63 70.46 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52592 482
SS-Chr 19BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 6 27.01 mg/d 7.32 17.92 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52618 482
SS.BN-(D8Rat163-D8Rat81)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 21 21.33 mg/d 6.67 30.55 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52623 482
LEW/Crl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 50692 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 3.33 ng/ml/h 1.41 3.46 radioimmunoassay 0 50715 481
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 11 3.37 ng/ml/h 0.66 2.2 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51004 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 5 6.62 ng/ml/h 1.19 2.66 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51008 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 1 8.99 ng/ml/h radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51014 481
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 13 0.34 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51278 481
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 13 0.25 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51648 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 11.16 ng/ml/h 0.5 1.41 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50397 481
LEW/Crl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.32 mg/dl 0.02 0.05 radioimmunoassay 0 50410 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 7 0.9 ng/ml/h 0.26 0.68 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50459 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 9.06 ng/ml/h 1.26 3.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50457 481
DA.F344-(D4Got44-D4Rat128)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 8 84.7 ng/ml 18.48 52.26 radioimmunoassay 0.0 0 68644 970
LEW/OlaHsd serum corticosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood corticosterone amount female 49 days-77 days 6 204.0 nmol/l 89.41 219.0 radioimmunoassay 0.0 0 68630 271
BB.SHR-(D4Got41-Tacr1)/K serum leptin level control condition Kloting N, et al., Obes Res 2005 Mar;13(3):589-95. blood leptin amount male 224 days 20 15.3 ng/ml 3.5 15.65 radioimmunoassay 0.0 0 ng/ml 67941 227
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) (for 7 days) then controlled sodium content diet (0.3 %) (for 7 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 77 days 4 293.8 pg/ml 39.4 78.8 radioimmunoassay 0.0 0 69656 736
WOKW/K serum insulin level control condition Kovacs P, et al., Biochem Biophys Res Commun 2000 Mar 24;269(3):660-5. blood insulin amount not specified 196 days-224 days 12 0.0 mg/dl 0.0 0.0 radioimmunoassay 0.0 0 96846 1123
Crl:SD plasma insulin level controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 63 days-77 days 9 51.0 mU/l 7.0 21.0 radioimmunoassay 0.0 0 F 75847 1540
Crl:SD plasma glucagon level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) then insulin (2 U/kg/d) (for 14 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucagon amount male 0 days 8 402.0 pmol/l 32.0 90.51 radioimmunoassay 0.0 0 FT 75924 1540
Crl:SD plasma insulin level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) then insulin (2 U/kg/d) (for 14 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 0 days 8 68.0 mU/l 3.0 8.49 radioimmunoassay 0.0 0 FT 75880 1540
SR/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 42.9 pg/ml 12.6 30.86 radioimmunoassay 0.0 ovx 63 days 102363 2686
LH/Mav plasma insulin level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 10 29.17 mU/l 1.42 4.49 radioimmunoassay 0.0 0 102093 2645
SHR/NCrlCrlj plasma renin activity level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. renin activity male 126 days 5 1.3 ng/ml/h 0.2 0.45 radioimmunoassay 0.0 unx 42 days 101262 2583
SD plasma renin activity level unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. renin activity male 0 days 5 5.2 ng/ml/h 2.24 5.0 radioimmunoassay 0.0 unx 13 days 101566 2602
WKY blood glucose level vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 160.56 mg/dl 8.64 27.32 radioimmunoassay 0.0 0 99101 2219
WKY blood glucose level streptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 523.26 mg/dl 27.18 85.95 radioimmunoassay 0.0 0 99104 2219
SR/NEisSlc kidney cortical adrenomedullin level controlled sodium chloride content diet (8 %) (for 14 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 70 days 8 0.56 fmol/mg 0.02 0.06 radioimmunoassay 0.0 0 102443 2689
SR/NEisSlc kidney medullary adrenomedullin level controlled sodium chloride content diet (8 %) (for 7 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 63 days 7 0.31 fmol/mg 0.02 0.06 radioimmunoassay 0.0 0 102447 2689
SR/NEisSlc kidney medullary adrenomedullin level controlled sodium chloride content diet (8 %) (for 14 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 70 days 8 0.34 fmol/mg 0.01 0.04 radioimmunoassay 0.0 0 102449 2689
SD heart left ventricle interstitial angiotensin II level during a period of time artificial aortocaval fistula (for 105 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. heart left ventricle interstitial angiotensin II amount male 175 days 10 1.9 pg/hr 0.1 0.32 radioimmunoassay 0.0 ACF 105 days heart left ventricle interstitial angiotensin II level during a period of time 99262 2278
SR/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 204.0 fmol/mg 38.0 radioimmunoassay 0.0 0 102225 2681
WKY plasma renin activity level controlled enalapril content drinking water (50 mg/l) (for 30 days) then puromycin aminonucleoside (50 mg/kg) Anderson S, et al., J Clin Invest. 1988 Nov;82(5):1757-68. renin activity male 0 days 10 100.3 ng/ml/h 18.6 58.82 radioimmunoassay 0.0 PA IV 50mg/kg 23 days 100423 2479
SS/NEisSlc plasma renin activity level controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. renin activity male 91 days 6 5.72 ng/ml/h 1.36 3.33 radioimmunoassay 0.0 0 100690 2519
Crl:WI serum aldosterone level control condition Korkmaz-Ic�z S, et al., Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H958-H971. doi: 10.1152/ajpheart.00956.2015. Epub 2016 Aug 12. blood aldosterone amount male 112 days 10 3.93 nmol/l 0.75 2.37 radioimmunoassay 0.0 0 102944 2783
SD serum testosterone level in utero condition (for 7 days) and corn oil (for 7 days) Jiang JT, et al., Toxicology. 2015 Dec 2;338:77-85. doi: 10.1016/j.tox.2015.10.006. Epub 2015 Oct 26. blood testosterone amount male 1 days 6 0.81 ng/ml 0.05 0.12 radioimmunoassay 1.0 0 98732 2158
SHR/N-cp plasma renin activity level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. renin activity male 140 days-168 days 8 38.0 ng/ml/h 2.0 5.66 radioimmunoassay 0.0 0 101534 2601
SHRSP/A3N plasma aldosterone level controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) and controlled enrasentan content diet (1200 ppm) (for 112 days) Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. blood aldosterone amount male 182 days-210 days 8 146.0 pg/ml 26.0 73.54 radioimmunoassay 0.0 0 107939 3100
GK pancreatic islet insulin release measurement glucose solution (16.7 mmol/l) (for 1.5 hours) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreatic beta cell physiology trait female 73 days 33 124.0 uU/islet/90min 6.0 34.47 radioimmunoassay 0.0 glucose 90 min ex vivo incubation 110633 3179
GK pancreatic islet insulin release measurement controlled dehydroepiandrosterone content diet (0.2 %) (for 28 days) then glucose solution (16.7 mmol/l) (for 1.5 hours) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreatic beta cell physiology trait female 73 days 33 83.5 uU/islet/90min 5.4 31.02 radioimmunoassay 0.0 glucose 90 min ex vivo incubation 110634 3179
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51318 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 9.13 ng/ml/h 0.66 1.87 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50396 481
LEW/Crl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 50411 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 8 0.7 ng/ml/h 0.15 0.42 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50455 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 2.08 ng/ml/h 0.23 0.56 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50458 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 8 1.22 ng/ml/h 0.11 0.31 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50461 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.31 mg/dl 0.03 0.06 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51895 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.32 mg/dl 0.02 0.04 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51900 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.32 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52219 482
SS-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 10 0.32 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52232 482
LE/BluGill plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.32 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52240 482
FHH-Chr 12BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 11 111.94 mg/d 15.39 51.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52405 482
FHH-Chr 10BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 175.8 mg/d 24.28 72.83 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52413 482
FHH-Chr 7BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 64.2 mg/d 29.52 88.56 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52424 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 11 7.16 mg/d 2.64 8.76 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52427 482
LE/BluGill plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 3.46 ng/ml/h 1.44 4.09 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52578 482
SS-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 19 27.04 mg/d 5.32 23.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52605 482
SS-Chr 1BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 20 6.78 mg/d 1.12 5.0 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52611 482
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 11 73.53 mg/d 19.27 63.93 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52616 482
SS-Chr XBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 6 124.69 mg/d 38.65 94.67 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52627 482
F344/NHsd plasma corticosterone level physical restraint (for 0.2 hours) Solberg LC, et al., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8 blood corticosterone amount female 105 days 17 503.7 ng/ml 32.4 133.59 radioimmunoassay 0 0 13130 105
WOKW/K serum leptin level control condition Kovacs P, et al., Biochem Biophys Res Commun 2000 Mar 24;269(3):660-5. blood leptin amount not specified 196 days-224 days 12 7.26 ng/ml 0.85 2.94 radioimmunoassay 0.0 0 96844 1123
DA.F344(Cia3e)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 4 136.24 ng/ml 45.53 91.06 radioimmunoassay 0.0 0 68647 970
SS/NEisSlc plasma renin activity level controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. renin activity male 91 days 6 8.35 ng/ml/h 2.34 5.73 radioimmunoassay 0.0 0 100691 2519
BluHsd:LE serum estradiol level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood estradiol amount male 98 days 8 290.0 pg/ml 10.0 28.28 radioimmunoassay 0.0 0 tritium-based 76255 1543
SR/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 17.1 pg/ml 4.6 11.27 radioimmunoassay 0.0 sham ovx 63 days 102361 2686
LH-Chr 13BN/Mav plasma insulin level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 10 30.84 mU/l 1.62 5.12 radioimmunoassay 0.0 0 102094 2645
SS plasma urotensin II level standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. blood urotensin II amount male 49 days 8 51.0 pg/ml 0.85 2.4 radioimmunoassay 0.0 0 102274 2683
SS/JrHsd serum vasopressin level gelled diet (200 g/kg/d) (for 8 days) then distilled water (for 6 days) Fenton RA, et al., Am J Physiol Renal Physiol. 2003 Jul;285(1):F143-51. Epub 2003 Apr 8. blood antidiuretic hormone amount male 0 days 6 2.75 pmol/l 0.3 0.73 radioimmunoassay 0.0 osmotic pump implant 6 days 102589 2691
SS/NEisSlc kidney cortical adrenomedullin level controlled sodium chloride content diet (8 %) (for 14 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 70 days 7 0.61 fmol/mg 0.03 0.09 radioimmunoassay 0.0 0 102444 2689
F344/StmMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount male 91 days 9 4.38 ng/dL 0.14 0.43 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from M to male to standardize across records, 7-30-2024 139556 3292
F344/StmMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount male 91 days 9 111.26 µg/dL 7.9 23.69 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from M to male to standardize across records, 7-30-2024 139555 3292
BN/NHsdMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount male 91 days 8 70.24 µg/dL 4.85 13.71 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from M to male to standardize across records, 7-30-2024 139039 3292
BUF/MnaMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount male 91 days 8 91.75 µg/dL 2.32 6.55 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from M to male to standardize across records, 7-30-2024 139297 3292
BN/NHsdMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount female 91 days 7 77.7 µg/dL 3.4 9.0 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from F to female to standardize across records, 7-30-2024 138923 3292
WKY/NCrl serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount female 91 days 8 133.49 µg/dL 2.64 7.48 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from F to female to standardize across records, 7-30-2024 139942 3292
WKY/NCrl serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount female 91 days 9 3.97 ng/dL 0.16 0.49 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from F to female to standardize across records, 7-30-2024 139943 3292
F344/StmMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount female 91 days 7 77.49 µg/dL 6.07 16.06 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from F to female to standardize across records, 7-30-2024 139426 3292
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 13 0.43 ng/ml/h 0.08 0.29 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51833 481
LEW/Crl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 4.31 ng/ml/h 1.53 3.06 radioimmunoassay 0 51959 481
LEW/Crl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 5 4.91 ng/ml/h 0.65 1.44 radioimmunoassay 0 51958 481
FHH-Chr 8BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 2 3.48 ng/ml/h 1.03 1.46 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52880 482
FHH-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 1 1.4 ng/ml/h radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52893 482
FHH-Chr 8BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 2 2.11 ng/ml/h 0.7 0.98 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52891 482
FHH/EurMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 38 2.57 ng/ml/h 0.36 2.21 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52899 482
FHH-Chr 15BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 2.41 ng/ml/h 0.58 1.53 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52900 482
FHH-Chr YBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 2.47 ng/ml/h 0.64 1.27 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52903 482
FHH-Chr 14BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 2.19 ng/ml/h 0.69 1.83 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52902 482
FHH-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 1.73 ng/ml/h 0.23 0.46 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52904 482
FHH-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 3 1.53 ng/ml/h 1.17 2.02 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52901 482
FHH-Chr 7BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 1.89 ng/ml/h 0.44 1.17 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52916 482
FHH-Chr XBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 4.63 ng/ml/h 0.97 2.16 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52920 482
SS-Chr 14BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 9 0.3 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52192 482
SS-Chr 6BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.38 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52193 482
SS-Chr 5BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.3 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52203 482
SS-Chr 13BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 18 0.35 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52212 482
SS-Chr XBN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 3 0.46 mg/dl 0.07 0.12 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52222 482
SS-Chr 19BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.32 mg/dl 0.0 0.01 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52228 482
SS-Chr XBN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 3 0.4 mg/dl 0.07 0.13 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52237 482
FHH-Chr 8BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.33 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52245 482
FHH-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 1 0.48 mg/dl radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52248 482
FHH-Chr 14BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 4 0.49 mg/dl 0.05 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52251 482
FHH-Chr 13BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 10 0.45 mg/dl 0.05 0.15 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52259 482
FHH-Chr 12BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 10 0.37 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52262 482
FHH-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.26 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52265 482
FHH-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.3 mg/dl 0.06 0.12 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52269 482
FHH-Chr 4BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 5 0.53 mg/dl 0.04 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52273 482
FHH-Chr 6BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 11 210.45 mg/d 31.16 103.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52395 482
FHH-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 171.32 mg/d 37.14 117.44 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52402 482
FHH-Chr 1BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 68.56 mg/d 16.62 52.55 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52415 482
FHH-Chr 10BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 6 264.36 mg/d 29.33 71.84 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52425 482
FHH-Chr 9BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 6 246.64 mg/d 17.37 42.55 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52429 482
SS-Chr 17BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 6 0.92 ng/ml/h 0.24 0.6 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52447 482
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 0.91 ng/ml/h 0.2 0.58 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52452 482
SS-Chr 15BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 0.28 ng/ml/h 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52453 482
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 0.42 ng/ml/h 0.09 0.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52459 482
SS-Chr YBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 12 0.26 ng/ml/h 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52463 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 41.24 mg/d 7.04 22.27 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52585 482
SS-Chr 20BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 44.12 mg/d 8.7 26.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52604 482
SS-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 21 42.57 mg/d 8.71 39.93 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52607 482
SS-Chr 16BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 49.66 mg/d 10.69 33.79 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52601 482
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 63 87.97 mg/d 9.45 74.97 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52610 482
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 17.97 mg/d 3.01 9.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52609 482
SS-Chr 1BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 19 1.61 mg/d 0.27 1.19 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52614 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 4.05 mg/d 1.24 3.93 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52625 482
SS-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 73.9 mg/d 13.02 41.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52628 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 21 2.16 mg/d 0.38 1.73 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52626 482
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 1 0.67 ng/ml/h radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50539 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 12.93 ng/ml/h 1.15 2.3 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50571 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 12 1.15 ng/ml/h 0.27 0.94 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51003 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 3 1.67 ng/ml/h 0.55 0.96 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51006 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 3 7.64 ng/ml/h 1.68 2.91 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51015 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.37 mg/dl 0.02 0.05 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51174 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.35 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51177 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 8 0.33 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51180 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.32 mg/dl 0.01 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51181 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 10 0.36 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51312 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.25 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51320 481
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 10 0.35 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51319 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 7 3.27 ng/ml/h 0.47 1.25 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51604 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 15 0.27 mg/dl 0.02 0.09 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51644 481
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 14 0.26 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51651 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.27 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51649 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.42 mg/dl 0.03 0.07 radioimmunoassay 0 50412 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 5 5.64 ng/ml/h 1.41 3.16 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50413 481
F344/NHsd plasma corticosterone level control condition Solberg LC, et al., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8 blood corticosterone amount female 105 days 17 94.7 ng/ml 21.2 87.41 radioimmunoassay 0 13122 105
DA.F344-(D4Arb30-D4Arb4)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 8 114.3 ng/ml 31.78 89.9 radioimmunoassay 0.0 0 68642 970
BC/CpbU serum aldosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood aldosterone amount female 49 days-77 days 6 1.44 nmol/l 0.21 0.52 radioimmunoassay 0.0 0 68624 271
PD/Cub serum insulin level fasting (for 16 hours) Seda O, et al., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22. blood insulin amount male 300 days 6 0.01 mg/dl 0.0 0.0 radioimmunoassay retroorbital plexus 0.0 0 70274 1318
WOKW serum leptin level control condition Kloting I, et al., Biochem Biophys Res Commun 2001 Jun 1;284(1):150-6. blood leptin amount female 196 days-224 days 12 serial mean 3.6 ng/ml radioimmunoassay ophthalmic venous plexus 0.0 0 Roche Cobas Mira Plus (Roche, Switzerland) average of measures taken at 196 days, 210 days and 224 days 67917 251
DA/K serum leptin level control condition Kloting I, et al., Biochem Biophys Res Commun 2001 Jun 1;284(1):150-6. blood leptin amount female 196 days-224 days 12 serial mean 1.8 ng/ml radioimmunoassay ophthalmic venous plexus 0.0 0 Roche Cobas Mira Plus (Roche, Switzerland) average of measures taken at 196 days, 210 days and 224 days 67918 251
Crl:SD plasma insulin level control condition Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 63 days-77 days 8 33.0 mU/l 2.0 5.66 radioimmunoassay 0.0 0 C 75848 1540
LOU/NimrOlaHsd plasma insulin-like growth factor 1 level controlled calorie content diet (2.9 kcal/g) (between 28 and 126 days) then fasting (for 16 hours) Marissal-Arvy N, et al., Growth Horm IGF Res. 2013 Dec;23(6):220-8. doi: 10.1016/j.ghir.2013.08.002. Epub 2013 Aug 19. blood insulin-like growth factor amount male 126 days 0 869.0 ng/ml 93.0 radioimmunoassay 0.0 0 84691 1598
Crl:SD plasma insulin level controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 0 days 0 53.0 mU/l 7.0 radioimmunoassay 0.0 0 F 75879 1540
SS/NEisSlc kidney medullary adrenomedullin level controlled sodium chloride content diet (8 %) (for 21 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 77 days 8 0.45 fmol/mg 0.01 0.04 radioimmunoassay 0.0 0 102452 2689
SHR/NCrlCrlj plasma angiotensin II level to plasma angiotensin I level ratio unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 8 0.77 null 0.05 0.14 radioimmunoassay 0.0 unx 42 days blood ang II level 101279 2583
SHR/NCrlCrlj plasma renin activity level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. renin activity male 126 days 8 9.8 ng/ml/h 1.7 4.81 radioimmunoassay 0.0 unx 42 days 101263 2583
SHR/NCrlCrlj plasma angiotensin I level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin I amount male 126 days 5 169.0 pg/ml 33.0 73.79 radioimmunoassay 0.0 unx 42 days 101270 2583
SHR/NCrlCrlj plasma angiotensin I level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin I amount male 126 days 9 279.0 pg/ml 21.0 63.0 radioimmunoassay 0.0 unx 42 days 101272 2583
SHR/NCrlCrlj plasma angiotensin I level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin I amount male 126 days 5 281.0 pg/ml 41.0 91.68 radioimmunoassay 0.0 unx 42 days 101273 2583
SS plasma urotensin II level controlled sodium chloride content diet (8 %) (for 42 days) Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. blood urotensin II amount male 91 days 8 52.0 pg/ml 4.38 12.4 radioimmunoassay 0.0 0 102276 2683
SS/NEisSlc kidney medullary adrenomedullin level controlled sodium chloride content diet (8 %) (for 7 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 63 days 8 0.31 fmol/mg 0.02 0.05 radioimmunoassay 0.0 0 102448 2689
SS/JrHsd serum vasopressin level gelled diet (200 g/kg/d) (for 8 days) then carbenoxolone (100 mg/kg/d) (for 6 days) Fenton RA, et al., Am J Physiol Renal Physiol. 2003 Jul;285(1):F143-51. Epub 2003 Apr 8. blood antidiuretic hormone amount male 0 days 6 2.54 pmol/l 0.2 0.49 radioimmunoassay 0.0 osmotic pump implant 6 days 102590 2691
WKY plasma renin activity level puromycin aminonucleoside (50 mg/kg) Anderson S, et al., J Clin Invest. 1988 Nov;82(5):1757-68. renin activity male 0 days 12 7.4 ng/ml/h 0.8 2.77 radioimmunoassay 0.0 PA IV 50mg/kg 0 100425 2479
WKY plasma renin activity level controlled enalapril content drinking water (50 mg/l) (between 63 and 77 days) then puromycin aminonucleoside (50 mg/kg) Anderson S, et al., J Clin Invest. 1988 Nov;82(5):1757-68. renin activity male 0 days 12 206.8 ng/ml/h 20.7 71.71 radioimmunoassay 0.0 PA IV 50mg/kg 0 100426 2479
SD heart left ventricle interstitial bradykinin level during a period of time sham surgical control condition (for 28 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. heart left ventricle interstitial bradykinin amount male 98 days 8 6.4 pg/hr 0.4 1.13 radioimmunoassay 0.0 sham ACF 28 days heart left ventricle interstitial bradykinin level during a period of time 99263 2278
SD heart left ventricle interstitial bradykinin level during a period of time artificial aortocaval fistula (for 28 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. heart left ventricle interstitial bradykinin amount male 98 days 9 9.3 pg/hr 1.1 3.3 radioimmunoassay 0.0 ACF 28 days heart left ventricle interstitial bradykinin level during a period of time 99264 2278
SD heart left ventricle interstitial bradykinin level during a period of time artificial aortocaval fistula (for 105 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. heart left ventricle interstitial bradykinin amount male 175 days 10 12.4 pg/hr 1.7 5.38 radioimmunoassay 0.0 ACF 105 days heart left ventricle interstitial bradykinin level during a period of time 99266 2278
SD plasma angiotensin II level artificial aortocaval fistula (for 28 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. blood angiotensin II amount male 98 days 9 107.0 pg/ml 7.0 21.0 radioimmunoassay 0.0 ACF 28 days 99276 2278
SS/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 82.7 fmol/mg 5.8 radioimmunoassay 0.0 0 102231 2681
SS/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 138.0 fmol/mg 10.0 radioimmunoassay 0.0 0 102230 2681
SS/NEisSlc urine aldosterone excretion rate controlled sodium content diet (0.3 %) (for 84 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. urine aldosterone amount male 84 days 6 5.22 ng/d 3.04 7.45 radioimmunoassay 0.0 0 ng/d 100693 2519
SHR/N-cp plasma renin activity level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. renin activity male 168 days-196 days 8 11.0 ng/ml/h 2.0 5.66 radioimmunoassay 0.0 0 101532 2601
Crlj:WI serum insulin level fasting (for 16 hours) Ohta T, et al., Br J Pharmacol. 1999 Apr;126(7):1674-80. doi: 10.1038/sj.bjp.0702481. blood insulin amount male 56 days 5 0.0 mg/dl 0.0 0.0 radioimmunoassay 0.0 0 110770 3185
GK pancreatic islet insulin release measurement glucose solution (2.8 mmol/l) (for 1.5 hours) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreatic beta cell physiology trait male 73 days 33 26.4 uU/islet/90min 3.7 21.25 radioimmunoassay 0.0 glucose 90 min ex vivo incubation 110627 3179
GK pancreatic islet insulin release measurement glucose solution (2.8 mmol/l) (for 1.5 hours) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreatic beta cell physiology trait female 73 days 33 33.0 uU/islet/90min 4.6 26.42 radioimmunoassay 0.0 glucose 90 min ex vivo incubation 110629 3179
GK pancreatic islet insulin release measurement controlled dehydroepiandrosterone content diet (0.2 %) (for 28 days) then glucose solution (16.7 mmol/l) (for 1.5 hours) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreatic beta cell physiology trait male 73 days 32 113.3 uU/islet/90min 7.5 42.43 radioimmunoassay 0.0 glucose 90 min ex vivo incubation 110632 3179
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 6 0.77 ng/ml/h 0.33 0.8 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50540 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51313 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 12 0.31 mg/dl 0.01 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51310 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 6 1.14 ng/ml/h 0.3 0.74 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51603 481
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) (for 28 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 70 days 4 98.8 pg/ml 15.9 31.8 radioimmunoassay 0.0 0 67281 736
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 3 0.33 mg/dl 0.02 0.03 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51986 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 14 0.32 mg/dl 0.02 0.09 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52036 481
WKY/NHsd plasma corticosterone level control condition Solberg LC, et al., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8 blood corticosterone amount male 105 days 24 31.7 ng/ml 4.2 20.58 radioimmunoassay 0 ng/ml 13118 105
WKY/NHsd plasma corticosterone level control condition Solberg LC, et al., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8 blood corticosterone amount female 105 days 20 113.0 ng/ml 18.9 84.52 radioimmunoassay 0 13121 105
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.39 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52194 482
SS-Chr 17BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.25 mg/dl 0.05 0.12 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52202 482
SS-Chr 13BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 17 0.33 mg/dl 0.02 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52216 482
SS-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.36 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52208 482
SS-Chr 1BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 14 0.33 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52221 482
SS-Chr 12BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.3 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52229 482
FHH/EurMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 12 0.4 mg/dl 0.03 0.12 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52246 482
FHH-Chr 6BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 76.18 mg/d 25.95 73.4 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52397 482
FHH-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 31.87 mg/d 11.62 34.85 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52400 482
FHH-Chr 4BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 5 146.25 mg/d 39.31 87.9 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52416 482
LE/BluGill urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 5.33 mg/d 0.83 2.48 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52433 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.49 ng/ml/h 0.16 0.49 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52436 482
SS-Chr 6BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 6 3.55 ng/ml/h 1.2 2.94 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52438 482
SS-Chr 10BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 26.81 mg/d 7.11 22.47 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52589 482
SS-Chr 7BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 11 20.95 mg/d 3.07 10.17 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52591 482
SS-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 52.06 mg/d 8.09 21.4 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52586 482
SS-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 138.24 mg/d 24.67 74.0 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52600 482
SS-Chr 7BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 11 15.16 mg/d 2.95 9.78 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52594 482
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 4.49 mg/d 0.37 1.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52613 482
SS-Chr 12BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 34.37 mg/d 6.33 17.9 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52624 482
DA.F344(Cia3c)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 6 169.18 ng/ml 16.59 40.64 radioimmunoassay 0.0 0 68645 970
DA.F344-(D20Arb2-D20Arb8)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 10 59.25 ng/ml 13.8 43.65 radioimmunoassay 0.0 0 68650 970
WKY/NHsd serum thyroid stimulating hormone level control condition Baum AE, et al., Endocrinology 2004 Oct 28;. blood thyroid-stimulating hormone amount male 70 days-0 days 16 5.28 ng/ml 0.29 1.16 radioimmunoassay 0.0 0 serum tsh 67897 252
BluHsd:LE serum testosterone level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood testosterone amount male 98 days 8 7.3 ng/ml 1.5 4.24 radioimmunoassay 0.0 0 tritium-based 76252 1543
SR/NEisSlc urine aldosterone excretion rate controlled sodium content diet (0.3 %) (for 49 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. urine aldosterone amount male 49 days 6 15.37 ng/d 1.03 2.52 radioimmunoassay 0.0 0 ng/d 100694 2519
MW plasma renin activity level nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. renin activity male 0 days 7 21.9 ng/ml/h 2.5 6.61 radioimmunoassay 0.0 5/6 nephrectomy 28 days 101046 2561
Crl:WI plasma renin activity level control condition Korkmaz-Ic�z S, et al., Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H958-H971. doi: 10.1152/ajpheart.00956.2015. Epub 2016 Aug 12. renin activity male 112 days 10 2.8 ng/ml/h 0.7 2.21 radioimmunoassay 0.0 0 102946 2783
WKY plasma aldosterone level controlled in utero environment (100 % of calories) (for 22 days) Riviere G, et al., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3. blood aldosterone amount male 112 days 5 470.0 pg/ml 8.0 17.89 radioimmunoassay 0.0 0 101691 2218
SR/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 103.0 fmol/mg 13.0 radioimmunoassay 0.0 0 102227 2681
SS/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 90.2 fmol/mg 9.9 radioimmunoassay 0.0 0 102232 2681
BN/NHsdMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount male 91 days 8 4.19 ng/dL 0.21 0.6 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from M to male to standardize across records, 7-30-2024 139040 3292
BUF/MnaMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount male 91 days 8 3.74 ng/dL 0.16 0.44 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from M to male to standardize across records, 7-30-2024 139298 3292
ACI/EurMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount female 91 days 8 2.48 ng/dL 0.2 0.58 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from F to female to standardize across records, 7-30-2024 138675 3292
F344/StmMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount female 91 days 7 2.81 ng/dL 0.22 0.57 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from F to female to standardize across records, 7-30-2024 139427 3292
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 8 0.32 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51809 481
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 9 1.75 ng/ml/h 0.31 0.92 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51834 481
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 14 1.08 ng/ml/h 0.12 0.45 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51840 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 4.01 ng/ml/h 1.09 2.43 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51843 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.27 mg/dl 0.01 0.04 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51901 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51899 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51905 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 8 0.25 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51987 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.29 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51985 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.27 mg/dl 0.02 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52044 481
FHH-Chr 5BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 2.6 ng/ml/h 0.56 1.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52884 482
FHH-Chr 13BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 10 4.42 ng/ml/h 0.78 2.47 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52894 482
FHH-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 6 3.02 ng/ml/h 0.98 2.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52896 482
FHH-Chr 17BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 0.68 ng/ml/h 0.16 0.42 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52909 482
FHH-Chr 11BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 3 1.02 ng/ml/h 0.4 0.69 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52912 482
FHH-Chr 11BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 5.01 ng/ml/h 2.7 6.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52914 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 0.26 ng/ml/h 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52918 482
SS-Chr 14BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.37 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52196 482
SS-Chr 6BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.32 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52198 482
SS-Chr 7BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.32 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52201 482
SS-Chr 10BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.34 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52199 482
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 9 0.42 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52207 482
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.36 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52206 482
SS-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 14 0.34 mg/dl 0.02 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52217 482
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 9 0.35 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52226 482
FHH-Chr 6BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.41 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52252 482
FHH-Chr 19BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.27 mg/dl 0.03 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52253 482
FHH-Chr 6BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.38 mg/dl 0.05 0.11 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52254 482
FHH-Chr 5BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.42 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52255 482
FHH-Chr 8BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 3 0.31 mg/dl 0.06 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52256 482
FHH/EurMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 39 0.43 mg/dl 0.02 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52264 482
FHH-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.35 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52263 482
FHH-Chr 17BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 11 0.52 mg/dl 0.05 0.15 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52275 482
FHH-Chr XBN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.61 mg/dl 0.08 0.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52278 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.33 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52284 482
FHH-Chr 1BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 9 0.35 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52289 482
FHH-Chr 19BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 227.43 mg/d 44.77 118.45 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52390 482
FHH-Chr 20BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 8 138.32 mg/d 33.41 94.5 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52401 482
FHH-Chr 5BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 201.41 mg/d 42.23 111.72 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52398 482
FHH-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 48.46 mg/d 29.49 88.47 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52406 482
FHH-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 8 139.15 mg/d 34.34 97.13 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52410 482
FHH-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 4 125.32 mg/d 56.48 112.96 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52409 482
FHH-Chr 16BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 43.12 mg/d 15.42 40.81 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52414 482
FHH-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 5 131.21 mg/d 42.63 95.32 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52420 482
FHH-Chr 16BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 8 82.04 mg/d 25.56 72.31 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52431 482
SS-Chr 14BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 9 0.87 ng/ml/h 0.09 0.27 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52437 482
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.41 ng/ml/h 0.15 0.44 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52456 482
SS-Chr 11BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 14 0.34 ng/ml/h 0.09 0.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52462 482
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 9 1.17 ng/ml/h 0.22 0.66 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52471 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 1.01 ng/ml/h 0.15 0.43 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52480 482
LE/BluGill plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 6 4.74 ng/ml/h 1.34 3.27 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52579 482
SS-Chr 17BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 176.23 mg/d 15.78 47.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52590 482
SS-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 57.74 mg/d 11.69 30.93 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52598 482
SS-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 46.16 mg/d 15.16 40.11 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52599 482
SS-Chr 4BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 53.64 mg/d 9.34 24.71 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52615 482
SS-Chr 4BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 11.71 mg/d 2.97 8.4 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52621 482
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 13.14 ng/ml/h 1.17 2.86 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50567 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 2 1.29 ng/ml/h 0.49 0.69 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50569 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 9 3.39 ng/ml/h 0.88 2.65 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51005 481
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 11 0.91 ng/ml/h 0.18 0.59 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51007 481
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 14 2.21 ng/ml/h 0.35 1.3 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51010 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 7.2 ng/ml/h 1.34 2.68 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51013 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51175 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 2 0.26 mg/dl 0.06 0.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51179 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 9 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51178 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.31 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51316 481
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 13 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51317 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.28 mg/dl 0.02 0.04 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51539 481
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 12 0.33 mg/dl 0.02 0.07 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51645 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.26 mg/dl 0.0 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51652 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.23 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51654 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 11.87 ng/ml/h 0.85 2.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50389 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 15 2.88 ng/ml/h 0.5 1.95 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50388 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 7 10.95 ng/ml/h 1.24 3.28 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50391 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 3 7.09 ng/ml/h 3.05 5.29 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50392 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 9 3.86 ng/ml/h 0.51 1.54 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50395 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 3 1.99 ng/ml/h 0.5 0.87 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50460 481
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 42 days 4 139.3 pg/ml 22.8 45.6 radioimmunoassay 0.0 0 67280 736
F344/NHsd serum thyroid stimulating hormone level control condition Baum AE, et al., Endocrinology 2004 Oct 28;. blood thyroid-stimulating hormone amount male 70 days-0 days 16 2.23 ng/ml 0.16 0.62 radioimmunoassay 0.0 0 serum tsh 12405 252
WKY/NHsd plasma corticosterone level physical restraint (for 0.2 hours) Solberg LC, et al., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8 blood corticosterone amount female 105 days 20 584.5 ng/ml 33.5 149.82 radioimmunoassay 0 0 13128 105
BC/CpbU serum corticosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood corticosterone amount female 49 days-77 days 6 718.0 nmol/l 172.28 422.0 radioimmunoassay 0.0 0 68628 271
PD/Cub serum insulin level controlled sucrose content diet (for 7 days) then fasting (for 16 hours) Seda O, et al., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22. blood insulin amount male 307 days 6 0.01 mg/dl 0.0 0.0 radioimmunoassay retroorbital plexus 0.0 0 70276 1318
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) (for 28 days) and controlled tempol content drinking water (0.5 mmol/l) (for 28 days) then controlled sodium content diet (0.3 %) (for 7 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 77 days 4 215.0 pg/ml 35.7 71.4 radioimmunoassay 0.0 0 69658 736
Crl:SD plasma insulin level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 63 days-77 days 8 26.0 mU/l 2.0 5.66 radioimmunoassay 0.0 0 CT 75850 1540
BluHsd:LE serum testosterone level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood testosterone amount male 98 days 8 10.0 ng/ml 1.2 3.39 radioimmunoassay 0.0 0 tritium-based 76253 1543
Crl:CD(SD) serum estradiol level maternal milk (for 20 days) and vehicle control condition (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood estradiol amount female 50 days 32 34.4 pg/ml 2.7 15.27 radioimmunoassay 0.0 0 76260 1558
F344/IcoCrlf plasma insulin-like growth factor 1 level controlled calorie content diet (2.9 kcal/g) (between 28 and 126 days) then fasting (for 16 hours) Marissal-Arvy N, et al., Growth Horm IGF Res. 2013 Dec;23(6):220-8. doi: 10.1016/j.ghir.2013.08.002. Epub 2013 Aug 19. blood insulin-like growth factor amount male 126 days 0 1381.0 ng/ml 95.0 radioimmunoassay 0.0 0 84693 1598
F344/IcoCrlf plasma insulin-like growth factor 1 level controlled calorie content diet (2.9 kcal/g) (between 28 and 126 days) then fasting (for 16 hours) Marissal-Arvy N, et al., Growth Horm IGF Res. 2013 Dec;23(6):220-8. doi: 10.1016/j.ghir.2013.08.002. Epub 2013 Aug 19. blood insulin-like growth factor amount female 126 days 0 775.0 ng/ml 125.0 radioimmunoassay 0.0 0 84694 1598
Crl:CD(SD) serum estradiol level maternal milk (for 20 days) and bisphenol A (250 ug/kg) (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood estradiol amount female 50 days 24 23.6 pg/ml 4.7 23.03 radioimmunoassay 0.0 0 76261 1558
SS/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 7.3 pg/ml 0.5 1.22 radioimmunoassay 0.0 ovx 63 days 102359 2686
BN-Chr 13LH/MavRrrc plasma insulin level to plasma glucose level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 9 3.06 mU/mmol 0.17 0.51 radioimmunoassay 0.0 0 mU/mmol plasma insulin level to plasma glucose level ratio (CMO:0003555) 102099 2645
LH-Chr 13BN/Mav plasma insulin level to plasma glucose level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 10 4.02 mU/mmol 0.23 0.73 radioimmunoassay 0.0 0 mU/mmol plasma insulin level to plasma glucose level ratio (CMO:0003555) 102098 2645
SR/NEisSlc kidney medullary adrenomedullin level controlled sodium chloride content diet (8 %) (for 21 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 77 days 7 0.34 fmol/mg 0.01 0.02 radioimmunoassay 0.0 0 102451 2689
WKY plasma corticosterone level controlled calorie content diet (100 % of calories) (for 14 days) Riviere G, et al., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3. blood corticosterone amount female 0 days 6 123.0 ng/ml 32.0 78.38 radioimmunoassay 0.0 0 99072 2218
SHR/NCrlCrlj plasma angiotensin II level to plasma angiotensin I level ratio unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 5 0.59 null 0.04 0.09 radioimmunoassay 0.0 unx 42 days blood ang II level 101281 2583
SHR/NCrlCrlj plasma renin activity level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. renin activity male 126 days 9 5.1 ng/ml/h 0.5 1.5 radioimmunoassay 0.0 unx 42 days 101264 2583
SD plasma renin activity level unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. renin activity male 0 days 5 13.3 ng/ml/h 5.5 12.3 radioimmunoassay 0.0 unx 13 days 101565 2602
SS/JrHsd serum corticosterone level gelled diet (200 g/kg/d) (for 8 days) then distilled water (for 6 days) Fenton RA, et al., Am J Physiol Renal Physiol. 2003 Jul;285(1):F143-51. Epub 2003 Apr 8. blood corticosterone amount male 0 days 6 1231.0 nmol/l 99.0 242.5 radioimmunoassay 0.0 osmotic pump implant 6 days 102586 2691
SR/JrHsd serum corticosterone level gelled diet (200 g/kg/d) (for 8 days) then distilled water (for 6 days) Fenton RA, et al., Am J Physiol Renal Physiol. 2003 Jul;285(1):F143-51. Epub 2003 Apr 8. blood corticosterone amount male 0 days 6 1262.0 nmol/l 21.0 51.44 radioimmunoassay 0.0 osmotic pump implant 6 days 102585 2691
WKY blood glucose level streptozotocin (60 mg/kg) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 520.92 mg/dl 28.8 91.07 radioimmunoassay 0.0 0 99102 2219
WKY blood glucose level streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 537.12 mg/dl 28.98 91.64 radioimmunoassay 0.0 0 99105 2219
SS urine urotensin II level to urine creatinine level ratio controlled sodium chloride content diet (8 %) (for 28 days) Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. urine urotensin II amount male 77 days 8 136.7 ng/g 16.05 45.4 radioimmunoassay 0.0 0 102278 2683
WKY plasma corticosterone level controlled calorie content diet (30 % of calories) (for 14 days) Riviere G, et al., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3. blood corticosterone amount female 0 days 6 409.0 ng/ml 28.0 68.59 radioimmunoassay 0.0 0 99071 2218
SD heart left ventricle interstitial angiotensin II level during a period of time artificial aortocaval fistula (for 28 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. heart left ventricle interstitial angiotensin II amount male 98 days 9 3.0 pg/hr 0.4 1.2 radioimmunoassay 0.0 ACF 28 days heart left ventricle interstitial angiotensin II level during a period of time 99260 2278
SD heart left ventricle interstitial angiotensin II level during a period of time sham surgical control condition (for 28 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. heart left ventricle interstitial angiotensin II amount male 98 days 8 1.5 pg/hr 0.2 0.57 radioimmunoassay 0.0 sham ACF 28 days heart left ventricle interstitial angiotensin II level during a period of time 99259 2278
SD plasma angiotensin II level sham surgical control condition (for 105 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. blood angiotensin II amount male 175 days 8 34.0 pg/ml 4.0 11.31 radioimmunoassay 0.0 sham ACF 105 days 99277 2278
SR/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 94.8 fmol/mg 9.2 radioimmunoassay 0.0 0 102228 2681
SR/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then peanut oil (0.2 ml) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 154.0 fmol/mg 24.0 radioimmunoassay 0.0 0 102226 2681
SR/NEisSlc plasma renin activity level controlled sodium content diet (0.3 %) (for 91 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. renin activity male 91 days 6 3.23 ng/ml/h 0.45 1.11 radioimmunoassay 0.0 0 100689 2519
SR/NEisSlc urine aldosterone excretion rate controlled sodium content diet (0.3 %) (for 84 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. urine aldosterone amount male 84 days 6 39.87 ng/d 11.4 27.92 radioimmunoassay 0.0 0 ng/d 100695 2519
MW plasma renin activity level sham surgical control condition (for 28 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. renin activity male 0 days 7 9.1 ng/ml/h 0.5 1.32 radioimmunoassay 0.0 sham surgery 28 days 101043 2561
MW plasma renin activity level nephrectomy (for 28 days) then enalapril (50 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. renin activity male 0 days 7 194.5 ng/ml/h 28.0 74.08 radioimmunoassay 0.0 5/6 nephrectomy 28 days 101045 2561
MNS plasma aldosterone level control condition Capasso G, et al., Am J Physiol Renal Physiol. 2005 Jun;288(6):F1173-82. doi: 10.1152/ajprenal.00228.2004. Epub 2005 Feb 1. blood aldosterone amount not specified 23 days-25 days 11 118.0 pg/ml 44.0 145.93 radioimmunoassay 0.0 0 104166 2926
SHRSP/A3N plasma aldosterone level controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) and controlled enrasentan content diet (2400 ppm) (for 112 days) Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. blood aldosterone amount male 182 days-210 days 8 151.0 pg/ml 27.0 76.37 radioimmunoassay 0.0 0 107940 3100
GK pancreatic islet insulin release measurement glucose solution (16.7 mmol/l) (for 1.5 hours) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreatic beta cell physiology trait male 73 days 33 113.4 uU/islet/90min 11.1 63.76 radioimmunoassay 0.0 glucose 90 min ex vivo incubation 110631 3179
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 3 0.29 mg/dl 0.0 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51321 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 7 2.5 ng/ml/h 0.55 1.46 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50387 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 8 10.84 ng/ml/h 1.35 3.83 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50416 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 1 0.35 mg/dl radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51903 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.31 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52045 481
SS.BN-(D8Rat163-D8Rat81)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 10 0.29 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52227 482
FHH-Chr 12BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.36 mg/dl 0.04 0.11 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52243 482
FHH-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 36.68 mg/d 12.67 33.51 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52408 482
FHH-Chr YBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 5 157.26 mg/d 66.11 147.84 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52411 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 20 5.13 mg/d 0.94 4.22 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52602 482
SS-Chr YBN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 17 43.12 mg/d 6.07 25.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52608 482
SS-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 13.96 mg/d 1.96 6.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52622 482
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) (for 28 days) and controlled tempol content drinking water (0.5 mmol/l) (for 28 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 70 days 4 57.3 pg/ml 18.1 36.2 radioimmunoassay 0.0 0 69655 736
DA/K serum insulin level control condition Kovacs P, et al., Biochem Biophys Res Commun 2000 Mar 24;269(3):660-5. blood insulin amount not specified 196 days-224 days 12 0.0 mg/dl 0.0 0.0 radioimmunoassay 0.0 0 96847 1123
DA.F344-(D10Arb21-D10Arb22)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 11 111.08 ng/ml 18.79 62.32 radioimmunoassay 0.0 0 68649 970
WOKW serum insulin level control condition Kloting I, et al., Biochem Biophys Res Commun 2001 Jun 1;284(1):150-6. blood insulin amount female 196 days-224 days 12 serial mean 0.0 mg/dl radioimmunoassay ophthalmic venous plexus 0.0 0 Roche Cobas Mira Plus (Roche, Switzerland) average of measures taken at 196 days, 210 days and 224 days 67919 251
Crl:CD(SD) serum progesterone level maternal milk (for 20 days) and vehicle control condition (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood progesterone amount female 50 days 32 12.5 ng/ml 2.8 15.84 radioimmunoassay 0.0 0 76262 1558
SS/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 15.7 pg/ml 1.7 4.16 radioimmunoassay 0.0 sham ovx 63 days 102358 2686
SS/NEisSlc kidney medullary adrenomedullin level controlled sodium chloride content diet (8 %) (for 14 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 70 days 7 0.31 fmol/mg 0.01 0.02 radioimmunoassay 0.0 0 102450 2689
WKY plasma renin activity level 0.9% sodium chloride solution (3 ml) Anderson S, et al., J Clin Invest. 1988 Nov;82(5):1757-68. renin activity male 0 days 11 11.9 ng/ml/h 1.0 3.32 radioimmunoassay 0.0 0 100424 2479
M520/NRrrcMcwi blood thyroxine amount controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount male 91 days 9 3.74 ng/dL 0.16 0.49 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from M to male to standardize across records, 7-30-2024 139814 3292
WKY/NCrl serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount male 91 days 10 115.89 µg/dL 3.88 12.28 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from M to male to standardize across records, 7-30-2024 140071 3292
BUF/MnaMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount female 91 days 9 2.59 ng/dL 0.19 0.56 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from F to female to standardize across records, 7-30-2024 139169 3292
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 9 1.07 ng/ml/h 0.29 0.86 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51835 481
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 12 0.38 ng/ml/h 0.04 0.14 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51837 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 8 1.69 ng/ml/h 0.33 0.94 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51839 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 6.96 ng/ml/h 0.75 2.12 radioimmunoassay 0 51957 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 6.9 ng/ml/h 2.37 5.82 radioimmunoassay 0 51960 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.32 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51984 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.31 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52035 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 10 0.33 mg/dl 0.01 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52041 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 3 0.26 mg/dl 0.01 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52040 481
FHH-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 7.44 ng/ml/h 1.44 3.8 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52878 482
FHH-Chr 19BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 2.2 ng/ml/h 0.96 2.54 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52882 482
FHH/EurMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 14 6.0 ng/ml/h 0.7 2.62 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52881 482
FHH-Chr 6BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 2.67 ng/ml/h 0.6 1.81 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52887 482
FHH-Chr 14BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 4.35 ng/ml/h 1.32 2.96 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52886 482
FHH-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 10 1.71 ng/ml/h 0.17 0.52 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52897 482
FHH-Chr 10BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 4.33 ng/ml/h 0.93 2.46 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52905 482
FHH-Chr 1BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 3.1 ng/ml/h 0.58 1.53 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52907 482
FHH-Chr 17BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 11 4.02 ng/ml/h 0.58 1.93 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52910 482
FHH-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 4 4.64 ng/ml/h 0.91 1.82 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52915 482
FHH-Chr 7BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 1.15 ng/ml/h 0.48 1.35 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52922 482
SS-Chr 7BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 11 0.29 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52204 482
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.45 mg/dl 0.03 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52211 482
SS-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 3 0.38 mg/dl 0.04 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52209 482
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.36 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52214 482
SS-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 13 0.34 mg/dl 0.03 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52215 482
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 53 0.37 mg/dl 0.01 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52220 482
SS-Chr 19BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.42 mg/dl 0.04 0.11 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52230 482
FHH-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 6 0.29 mg/dl 0.02 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52261 482
FHH-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 3 0.83 mg/dl 0.28 0.48 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52266 482
FHH-Chr YBN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.44 mg/dl 0.03 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52268 482
FHH-Chr 1BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.35 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52272 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.24 mg/dl 0.03 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52283 482
FHH-Chr XBN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.51 mg/dl 0.1 0.22 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52285 482
FHH-Chr 8BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 29.59 mg/d 7.04 18.64 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52388 482
FHH-Chr 20BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 59.49 mg/d 19.2 60.71 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52404 482
LE/BluGill urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 7.25 mg/d 1.35 3.56 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 52434 482
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 1.44 ng/ml/h 0.35 0.98 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52442 482
SS-Chr 15BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 3 1.73 ng/ml/h 0.2 0.35 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52454 482
SS-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 2.16 ng/ml/h 0.15 0.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52458 482
SS-Chr 11BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 14 1.11 ng/ml/h 0.26 0.96 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52460 482
SS-Chr 13BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 17 1.13 ng/ml/h 0.29 1.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52457 482
SS-Chr 13BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 17 0.43 ng/ml/h 0.09 0.35 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52461 482
SS-Chr XBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 3 1.82 ng/ml/h 0.72 1.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52467 482
SS-Chr 4BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 0.5 ng/ml/h 0.14 0.36 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52470 482
SS-Chr 19BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 0.27 ng/ml/h 0.04 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52473 482
SS-Chr 12BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 0.29 ng/ml/h 0.05 0.14 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52474 482
SS.BN-(D8Rat163-D8Rat81)/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 18 0.66 ng/ml/h 0.14 0.58 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52478 482
SS-Chr XBN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 1.04 ng/ml/h 0.33 0.65 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52482 482
SS-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 11 27.35 mg/d 3.58 11.87 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52582 482
SS-Chr 9BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 64.52 mg/d 11.28 35.68 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52584 482
SS-Chr 5BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 27.89 mg/d 5.0 15.81 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52595 482
SS-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 55.99 mg/d 8.97 23.72 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52603 482
SS-Chr 19BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 28.62 mg/d 8.44 23.88 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52620 482
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 3 0.64 ng/ml/h 0.27 0.47 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50536 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 9.02 ng/ml/h 1.47 3.59 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50537 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 5 2.8 ng/ml/h 0.87 1.94 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50565 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 5 3.3 ng/ml/h 0.43 0.97 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50568 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.37 mg/dl 0.03 0.07 radioimmunoassay 0 50693 481
LEW/Crl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 4 1.36 ng/ml/h 0.42 0.83 radioimmunoassay 0 50714 481
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 6.46 ng/ml/h 0.58 1.64 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50895 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 5 12.61 ng/ml/h 1.89 4.23 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51002 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 7 4.42 ng/ml/h 0.57 1.51 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51009 481
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 9 1.9 ng/ml/h 0.26 0.78 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51012 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 3.33 ng/ml/h 0.45 1.11 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51011 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 15 0.39 mg/dl 0.06 0.21 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51172 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.35 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51171 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 3 0.28 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51176 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.31 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51182 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.25 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51309 481
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 12 0.3 mg/dl 0.01 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51314 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 2 0.37 mg/dl 0.07 0.09 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51537 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.35 mg/dl 0.02 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51534 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.35 mg/dl 0.01 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51536 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.28 mg/dl 0.06 0.14 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51533 481
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 1.65 ng/ml/h 0.44 0.98 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51620 481
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 8 5.34 ng/ml/h 0.79 2.24 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51621 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.23 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51643 481
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 12 0.31 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51653 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 3 0.28 mg/dl 0.03 0.05 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51655 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.28 mg/dl 0.0 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51656 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 9 11.85 ng/ml/h 0.69 2.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50394 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 2 5.07 ng/ml/h 0.24 0.33 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50415 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 8 9.0 ng/ml/h 0.76 2.15 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50462 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 8 1.93 ng/ml/h 0.26 0.74 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50465 481
DA/Bkl plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 11 47.39 ng/ml 10.77 35.72 radioimmunoassay 0.0 0 68639 970
DA.F344-Aia1/2 plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 8 112.73 ng/ml 20.68 58.49 radioimmunoassay 0.0 0 68641 970
DA.F344-(D10Arb20-D10Arb22)/Arb plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 0 days 9 89.91 ng/ml 18.48 55.45 radioimmunoassay 0.0 0 68648 970
BB.WOKW-(D4Got41-Fabp1)/K serum leptin level control condition Kloting N, et al., Obes Res 2005 Mar;13(3):589-95. blood leptin amount male 224 days 16 7.7 ng/ml 2.1 8.4 radioimmunoassay 0.0 0 67942 227
LEW/OlaHsd serum aldosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood aldosterone amount female 49 days-77 days 6 0.63 nmol/l 0.13 0.32 radioimmunoassay 0.0 0 68626 271
BN/Cub serum insulin level controlled sucrose content diet (for 7 days) then fasting (for 16 hours) Seda O, et al., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22. blood insulin amount male 307 days 6 0.01 mg/dl 0.0 0.0 radioimmunoassay retroorbital plexus 0.0 0 70277 1318
F344/NHsd serum thyroid stimulating hormone level control condition Baum AE, et al., Endocrinology 2004 Oct 28;. blood thyroid-stimulating hormone amount female 70 days-0 days 15 1.13 ng/ml 0.02 0.07 radioimmunoassay 0.0 0 serum tsh 67896 252
DA/K serum insulin level control condition Kloting I, et al., Biochem Biophys Res Commun 2001 Jun 1;284(1):150-6. blood insulin amount female 196 days-224 days 12 serial mean 0.0 mg/dl radioimmunoassay ophthalmic venous plexus 0.0 0 Roche Cobas Mira Plus (Roche, Switzerland) average of measures taken at 196 days, 210 days and 224 days 67920 251
SS/NEisSlc plasma aldosterone level controlled sodium content diet (8 %) (for 28 days) and controlled tempol content drinking water (0.5 mmol/l) (for 28 days) then controlled sodium content diet (0.3 %) (for 28 days) Kitada K, et al., PLoS One. 2012;7(7):e41896. Epub 2012 Jul 24. blood aldosterone amount male 98 days 4 327.5 pg/ml 46.4 92.8 radioimmunoassay 0.0 0 69659 736
Crl:SD plasma insulin level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood insulin amount male 63 days-77 days 10 32.0 mU/l 4.0 12.65 radioimmunoassay 0.0 0 FT 75849 1540
BluHsd:LE serum estradiol level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood estradiol amount male 98 days 8 370.0 pg/ml 120.0 339.41 radioimmunoassay 0.0 0 tritium-based 76254 1543
Crl:SD plasma glucagon level controlled metformin content drinking water (350-500 mg/kg/d) (between 21 and 35 days) then controlled fructose content diet (66 %) (between 14 and 28 days) Verma S, et al., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7. blood glucagon amount male 0 days 8 353.0 pmol/l 27.0 76.37 radioimmunoassay 0.0 0 FT 75923 1540
ISIAH plasma corticosterone level physical restraint in tube type rodent restrainer (for 0.5 hours) Redina OE, et al., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502. blood corticosterone amount male 180 days 10 321.0 ng/ml 22.0 69.57 radioimmunoassay 0.0 0 97061 1818
SS/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 21.2 pg/ml 3.2 7.84 radioimmunoassay 0.0 ovx 63 days 102360 2686
BN/NHsdMcwi plasma insulin level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 10 20.37 mU/l 0.91 2.88 radioimmunoassay 0.0 0 102092 2645
SHR/NCrlCrlj plasma angiotensin II level to plasma angiotensin I level ratio unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 9 0.34 null 0.04 0.12 radioimmunoassay 0.0 unx 42 days blood ang II level 101280 2583
SHR/NCrlCrlj plasma renin activity level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. renin activity male 126 days 5 5.5 ng/ml/h 1.7 3.8 radioimmunoassay 0.0 unx 42 days 101265 2583
SHR/NCrlCrlj plasma angiotensin I level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin I amount male 126 days 8 338.0 pg/ml 28.0 79.2 radioimmunoassay 0.0 unx 42 days 101271 2583
SS/JrHsd serum corticosterone level gelled diet (200 g/kg/d) (for 8 days) then carbenoxolone (100 mg/kg/d) (for 6 days) Fenton RA, et al., Am J Physiol Renal Physiol. 2003 Jul;285(1):F143-51. Epub 2003 Apr 8. blood corticosterone amount male 0 days 6 1484.0 nmol/l 53.0 129.82 radioimmunoassay 0.0 osmotic pump implant 6 days 102587 2691
WKY blood glucose level streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 534.6 mg/dl 22.5 71.15 radioimmunoassay 0.0 0 99106 2219
SHR/NCrlCrlj plasma angiotensin II level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 8 26.6 pg/ml 3.6 10.18 radioimmunoassay 0.0 unx 42 days blood ang II level 101275 2583
SHR/NCrlCrlj plasma angiotensin II level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 9 9.3 pg/ml 1.4 4.2 radioimmunoassay 0.0 unx 42 days blood ang II level 101276 2583
SR/Hsd plasma urotensin II level controlled sodium chloride content diet (8 %) (for 42 days) Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. blood urotensin II amount male 91 days 8 60.0 pg/ml 2.26 6.4 radioimmunoassay 0.0 0 102277 2683
SR/Hsd urine urotensin II level to urine creatinine level ratio controlled sodium chloride content diet (8 %) (for 28 days) Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. urine urotensin II amount male 77 days 8 181.3 ng/g 29.66 83.9 radioimmunoassay 0.0 0 102279 2683
SS/NEisSlc kidney cortical adrenomedullin level controlled sodium chloride content diet (8 %) (for 7 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 63 days 8 0.62 fmol/mg 0.02 0.05 radioimmunoassay 0.0 0 102442 2689
SS/NEisSlc kidney cortical adrenomedullin level controlled sodium chloride content diet (8 %) (for 21 days) Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. kidney adrenomedullin amount male 77 days 8 0.74 fmol/mg 0.02 0.06 radioimmunoassay 0.0 0 102446 2689
SD heart left ventricle interstitial bradykinin level during a period of time sham surgical control condition (for 105 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. heart left ventricle interstitial bradykinin amount male 175 days 8 7.4 pg/hr 1.4 3.96 radioimmunoassay 0.0 sham ACF 105 days heart left ventricle interstitial bradykinin level during a period of time 99265 2278
SD plasma angiotensin II level sham surgical control condition (for 28 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. blood angiotensin II amount male 98 days 8 29.0 pg/ml 3.0 8.49 radioimmunoassay 0.0 sham ACF 28 days 99275 2278
SD plasma bradykinin level sham surgical control condition (for 105 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. blood bradykinin amount male 175 days 8 17.0 pg/ml 2.0 5.66 radioimmunoassay 0.0 sham ACF 105 days 99281 2278
WKY plasma renin activity level 0.9% sodium chloride solution (3 ml) Anderson S, et al., J Clin Invest. 1988 Nov;82(5):1757-68. renin activity male 0 days 10 10.7 ng/ml/h 1.7 5.38 radioimmunoassay 0.0 0 100421 2479
WKY plasma renin activity level puromycin aminonucleoside (50 mg/kg) Anderson S, et al., J Clin Invest. 1988 Nov;82(5):1757-68. renin activity male 0 days 11 8.8 ng/ml/h 1.0 3.32 radioimmunoassay 0.0 PA IV 50mg/kg 23 days 100422 2479
SS/NEisSlc plasma renin activity level controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. renin activity male 91 days 12 3.6 ng/ml/h 1.32 4.57 radioimmunoassay 0.0 0 100687 2519
GK/MolTac serum aldosterone level control condition Korkmaz-Ic�z S, et al., Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H958-H971. doi: 10.1152/ajpheart.00956.2015. Epub 2016 Aug 12. blood aldosterone amount male 112 days 8 3.63 nmol/l 0.91 2.59 radioimmunoassay 0.0 0 102945 2783
SHR/N-cp plasma renin activity level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. renin activity male 168 days-196 days 8 52.0 ng/ml/h 8.0 22.63 radioimmunoassay 0.0 0 101533 2601
MHS plasma aldosterone level control condition Capasso G, et al., Am J Physiol Renal Physiol. 2005 Jun;288(6):F1173-82. doi: 10.1152/ajprenal.00228.2004. Epub 2005 Feb 1. blood aldosterone amount not specified 23 days-25 days 11 150.0 pg/ml 30.0 99.5 radioimmunoassay 0.0 0 104167 2926
SHRSP/A3N plasma proANF 31-67 peptide level control condition Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. blood atrial natriuretic factor amount male 182 days-210 days 8 231.0 pg/ml 45.0 127.28 radioimmunoassay 0.0 0 107941 3100
MWF plasma direct renin activity level control condition Schie�l IM, etal., J Pharmacol Exp Ther. 2015 May;353(2):299-306. doi: 10.1124/jpet.114.222125. Epub 2015 Feb 13. renin activity male 364 days 6 1.3 ng AI/ml/h 0.1 0.24 radioimmunoassay tail 0.0 0 109065 3113
GK/CskCrlj serum insulin level fasting (for 16 hours) Ohta T, et al., Br J Pharmacol. 1999 Apr;126(7):1674-80. doi: 10.1038/sj.bjp.0702481. blood insulin amount male 56 days 5 0.01 mg/dl 0.0 0.0 radioimmunoassay 0.0 0 110771 3185
GK pancreatic islet insulin level controlled dehydroepiandrosterone content diet (0.2 %) (for 28 days) Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreas molecular composition trait female 73 days 2 0.83 mU/islet 0.13 0.18 radioimmunoassay 0.0 0 110626 3179
GK pancreatic islet insulin level control condition Ladriere L, et al., Cell Biochem Funct. 1997 Dec;15(4):287-92. doi: 10.1002/(SICI)1099-0844(199712)15:4<287::AID-CBF753>3.0.CO;2-X. pancreas molecular composition trait male 73 days 2 0.53 mU/islet 0.1 0.14 radioimmunoassay 0.0 0 110623 3179
MNS plasma aldosterone level control condition Capasso G, etal., Am J Physiol Renal Physiol. 2008 Aug;295(2):F556-67. doi: 10.1152/ajprenal.00340.2007. Epub 2008 May 14. blood aldosterone amount not specified 85 days-87 days 11 69.0 pg/ml 26.0 86.23 radioimmunoassay 0.0 0 110156 3164
MHS plasma aldosterone level control condition Capasso G, etal., Am J Physiol Renal Physiol. 2008 Aug;295(2):F556-67. doi: 10.1152/ajprenal.00340.2007. Epub 2008 May 14. blood aldosterone amount not specified 85 days-87 days 11 397.0 pg/ml 50.0 165.83 radioimmunoassay 0.0 0 110157 3164
LEW/Crl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.33 mg/dl 0.01 0.03 radioimmunoassay 0 50691 481
LEW/Crl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 6 2.17 ng/ml/h 0.86 2.11 radioimmunoassay 0 50713 481
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 12 8.82 ng/ml/h 1.04 3.62 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50896 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 5 1.32 ng/ml/h 0.64 1.42 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51605 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 5 5.67 ng/ml/h 1.28 2.87 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50390 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.29 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52039 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.3 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52042 481
WKY/NHsd plasma corticosterone level physical restraint (for 0.2 hours) Solberg LC, et al., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8 blood corticosterone amount male 105 days 24 287.5 ng/ml 21.0 102.88 radioimmunoassay 0 0 ng/ml 13124 105
SS-Chr 17BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 5 0.34 mg/dl 0.05 0.12 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52200 482
SS-Chr 5BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.3 mg/dl 0.02 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52205 482
SS-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.35 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52238 482
FHH-Chr 12BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 45.57 mg/d 19.51 61.71 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52386 482
FHH/EurMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 16 63.36 mg/d 21.06 84.26 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52389 482
FHH-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 79.22 mg/d 28.78 86.34 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52403 482
FHH-Chr 4BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 84.39 mg/d 36.1 108.31 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52419 482
FHH-Chr 7BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 13 152.95 mg/d 36.62 132.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52430 482
SS-Chr 14BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 0.42 ng/ml/h 0.1 0.29 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52441 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 12 86.57 mg/d 11.34 39.28 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52581 482
SS-Chr 12BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 160.7 mg/d 27.11 81.32 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52619 482
F344/NHsd plasma corticosterone level controlled exposure to ambient light (for 12 hours) Potenza MN, et al., Biol Psychiatry 2004 Mar 15;55(6):634-41. blood corticosterone amount male 49 days-59 days 9 95.9 ng/ml 16.73 50.19 radioimmunoassay 0.0 0 68640 970
LEW/OlaHsd serum corticosterone level controlled olive oil content diet (5 %) (for 28 days) and controlled cholesterol content diet (2 %) (for 28 days) then fasting (for 16 hours) Bonne AC, et al., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2072-9. blood corticosterone amount male 49 days-77 days 6 46.0 nmol/l 16.74 41.0 radioimmunoassay 0.0 0 68629 271
MW plasma renin activity level nephrectomy (for 28 days) then control condition Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. renin activity male 0 days 7 3.8 ng/ml/h 0.7 1.85 radioimmunoassay 0.0 5/6 nephrectomy 28 days 101044 2561
SHRSP/A3N plasma proANF 31-67 peptide level controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. blood atrial natriuretic factor amount male 182 days-210 days 8 441.0 pg/ml 71.0 200.82 radioimmunoassay 0.0 0 107942 3100
SD plasma bradykinin level artificial aortocaval fistula (for 28 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. blood bradykinin amount male 98 days 9 28.0 pg/ml 2.0 6.0 radioimmunoassay 0.0 ACF 28 days 99280 2278
SD plasma bradykinin level artificial aortocaval fistula (for 105 days) Wei CC, et al., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. blood bradykinin amount male 175 days 10 29.0 pg/ml 5.0 15.81 radioimmunoassay 0.0 ACF 105 days 99282 2278
WKY/NCrl serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount male 91 days 10 4.46 ng/dL 0.14 0.46 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from M to male to standardize across records, 7-30-2024 140072 3292
ACI/EurMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount male 91 days 8 3.08 ng/dL 0.18 0.52 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from M to male to standardize across records, 7-30-2024 138804 3292
BN/NHsdMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount female 91 days 7 3.47 ng/dL 0.19 0.51 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from F to female to standardize across records, 7-30-2024 138924 3292
M520/NRrrcMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount female 91 days 9 2.91 ng/dL 0.14 0.41 radioimmunoassay 0 RIA; RRID:AB_2940788 Serum total T4 Changed sex from F to female to standardize across records, 7-30-2024 139685 3292
ACI/EurMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount male 91 days 8 86.43 µg/dL 4.34 12.28 radioimmunoassay 0 RIA; RRID:AB_2940789 Serum total T3 Changed sex from M to male to standardize across records, 7-30-2024 138803 3292