Phenominer Database Results (655 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 185.5 mmHg 4.5 7.79 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65653 613
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 151.6 mmHg 3.9 6.75 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65661 613
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 131.7 mmHg 3.2 5.54 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65664 613
WKY/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 110.0 mmHg 7.0 14.0 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65670 613
WKY/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 105.2 mmHg 2.9 5.02 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65672 613
WKY/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 112.2 mmHg 2.7 4.68 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65673 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 115.4 mmHg 4.4 7.62 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65681 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 123.9 mmHg 3.6 6.24 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65684 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 144.2 mmHg 12.1 20.96 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65690 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 178.3 mmHg 13.0 22.52 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65695 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 155.8 mmHg 3.7 6.41 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65698 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 149.3 mmHg 7.0 12.12 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65701 613
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 79 and 80 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 147 days-149 days 1 219.7 mmHg 1.7 1.7 intra-aortic abdominal radiotelemetry 86400 0 65053 283
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 27 and 28 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 67 days-69 days 5 125.2 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry 86400 0 65057 283
SS.SR-(D3Arb14-D3Mco36)/Mco diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 79 and 80 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 147 days-149 days 2 162.3 mmHg 2.2 3.11 intra-aortic abdominal radiotelemetry 86400 0 65070 283
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 182.0 mmHg 6.9 11.95 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65616 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 106.3 mmHg 3.6 6.24 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65630 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 94.1 mmHg 3.8 6.58 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65632 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 123.0 mmHg 3.5 6.06 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65635 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 95.1 mmHg 1.6 2.77 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65642 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 109.3 mmHg 1.9 3.29 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65646 613
WKY/Gcrc systolic blood pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 124 days-128 days 6 continuous mean 160.3 mmHg 3.92 9.6 intra-aortic abdominal radiotelemetry abdominal aorta 0 11622 109
WKY/Gcrc systolic blood pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 124 days-128 days 6 continuous mean 142.1 mmHg 2.78 6.8 intra-aortic abdominal radiotelemetry abdominal aorta 0 11623 109
WKY/Gcrc pulse pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 45.9 mmHg 1.14 2.8 intra-aortic abdominal radiotelemetry abdominal aorta 0 11640 109
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 83.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11702 119
LEW/Crlc absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 43 days-51 days 0 8.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 13341 344
WKY.SHRSP-(Shbg-Atp1b2)/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 33 91.08 mmHg 0.87 5.0 intra-aortic abdominal radiotelemetry 0 12660 281
SS.LEW-(D1Rat211-D1Rat18)/Mco heart rate controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. heart pumping trait male 73 days-80 days 8 404.0 beats/min 5.0 14.14 intra-aortic abdominal radiotelemetry 10 0 diurnal difference 65504 611
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 43 and 47 days) Grondin M, et al., Physiol Genomics 2005 Mar 21;21(1):112-6. Epub 2005 Jan 4. arterial blood pressure trait male 88 days-92 days 19 169.0 mmHg 4.0 17.44 intra-aortic abdominal radiotelemetry 0 measure every 2 min for 24 hrs 12422 261
SS.MNS-(D2Mit6-D2Rat166)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 9 148.0 mmHg 4.0 12.0 intra-aortic abdominal radiotelemetry 0 none 12324 242
SS.MNS-(D2Mit6-D2Rat303)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 9 168.0 mmHg 4.0 12.0 intra-aortic abdominal radiotelemetry 0 none 12325 242
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 21 serial mean 177.0 mmHg 6.0 27.5 intra-aortic abdominal radiotelemetry abdominal aorta 1036800.0 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12737 304
SS.LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 16 serial mean 150.0 mmHg 6.0 24.0 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12741 304
SS.LEW-(D10Mco15-D10Mgh1)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 6 serial mean 180.0 mmHg 6.0 14.7 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12742 304
SS.MNS-(D2Chm25-D2Rat131)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 5 139.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry 0 12358 242
SS.MNS-(D2Chm25-D2Mit14)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 8 139.0 mmHg 5.0 14.14 intra-aortic abdominal radiotelemetry 0 12360 242
SS.LEW-(D17Rat65-Prl)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 43 and 47 days) Grondin M, et al., Physiol Genomics 2005 Mar 21;21(1):112-6. Epub 2005 Jan 4. arterial blood pressure trait male 88 days-92 days 5 139.0 mmHg 5.0 11.18 intra-aortic abdominal radiotelemetry 0 measure every 2 min for 24 hrs 12466 261
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 16 184.0 mmHg 4.0 16.0 intra-aortic abdominal radiotelemetry aorta 0 12595 269
LEW/Crlc mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 6 96.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry aorta 0 12617 269
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 105.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11697 119
WKY/Gcrc pulse pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 124 days-128 days 6 continuous mean 50.0 mmHg 1.76 4.3 intra-aortic abdominal radiotelemetry abdominal aorta 0 11630 109
SS.LEW-(D10Chm224-D10Chm6)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 9 serial mean 138.0 mmHg 6.0 18.0 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12748 304
SS.SHR-(D9Mco72-D9Mco93)/Mco heart rate controlled sodium content diet (2 %) (for 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart pumping trait male 75 days-79 days 5 389.0 beats/min 9.6 21.47 intra-aortic abdominal radiotelemetry 172800 0 64989 305
SHRSP/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 142.1 mmHg 2.3 3.98 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65586 613
WKY/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 99.6 mmHg 3.1 5.37 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65592 613
WKY/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 4 continuous mean 95.5 mmHg 6.4 12.8 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65595 613
WKY/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 4 continuous mean 127.8 mmHg 7.9 15.8 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65598 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 164.3 mmHg 1.9 3.29 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65602 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 144.7 mmHg 2.9 5.02 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65603 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 117.4 mmHg 2.8 4.85 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65606 613
SS.LEW-(D10Wox51-D10Rat27)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 5 140.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67878 830
SS.LEW-(D10Chm128-D10Chm121)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 9 133.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67881 830
SS.LEW-(D10Chm224-D10Chm222)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 6 139.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67884 830
SS/JrHsd systolic blood pressure controlled sodium content diet (8 %) (between 55 and 56 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait male 139 days-140 days 6 220.0 mmHg 7.1 17.4 intra-aortic abdominal radiotelemetry 0.0 0 67851 810
SS/JrHsd systolic blood pressure controlled sodium content diet (8 %) (between 83 and 84 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait female 167 days-168 days 8 199.5 mmHg 6.93 19.6 intra-aortic abdominal radiotelemetry 0.0 0 67857 810
SS mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 12 178.0 mmHg 4.0 13.86 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70466 1438
SS.LEW-(D2Rat199-D2Mco17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 204.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70479 1438
SS.LEW-(D10Chm10-D10Rat11)/Ayd absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 15.0 mmHg 2.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69727 344
SS/Jr percent change in heart rate sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 10.0 % 0.3 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69741 344
SS.LEW-(D10Chm10-D10Rat11)/Ayd maximum change in heart rate to change in mean arterial blood pressure ratio sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 -2.6 beats/min/mmHg 0.2 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion Maximum slope, bpm/mm Hg 69743 344
SS.LEW-(D10Chm246-D10Chm257)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 10 151.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70490 1438
SS/JrHsd systolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 9 194.4 mmHg 6.2 18.6 intra-aortic abdominal radiotelemetry 0.0 0 70351 1358
SS.SR-(rs65785750-rs13452155)/Opaz systolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 10 185.9 mmHg 3.8 12.02 intra-aortic abdominal radiotelemetry 0.0 0 70352 1358
SS.SR-(rs106870553-rs63922710)/Opaz pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 10 51.84 mmHg 1.4 4.43 intra-aortic abdominal radiotelemetry 0.0 0 70569 1458
SS.LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 7 150.0 mmHg 3.0 7.94 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70436 1438
SS.LEW-(D17Chm14-D17Rat181)/Ayd absolute change in heart rate sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 43 days-50 days 0 58.0 beats/min 6.0 intra-aortic abdominal radiotelemetry 0.0 0 69697 344
SS/JrHsd diastolic blood pressure controlled sodium content diet (8 %) (between 55 and 56 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait male 139 days-140 days 6 162.7 mmHg 7.88 19.3 intra-aortic abdominal radiotelemetry 0.0 0 67869 810
SS.SR-(D2Rat352-rs63922710)/Opaz systolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 6 168.4 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0.0 0 70558 1458
SS.MNS-(D2Chm90-D2Rat38)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 144.0 mmHg 4.0 11.31 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70455 1438
SS.SR-(D2Rat352-rs63922710)/Opaz diastolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 6 129.0 mmHg 2.9 7.1 intra-aortic abdominal radiotelemetry 0.0 0 70563 1458
SS.LEW-(D18Rat55-D18Mgh2)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 7 148.0 mmHg 5.0 13.23 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84483 1438
SS-Chr 12BN.SS-(D12Hmgc3-D12Rat79)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 67 days-77 days 8 serial mean 119.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96866 1718
SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi mean arterial blood pressure controlled sodium content diet (0.3 %) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. arterial blood pressure trait male 66 days-73 days 9 serial mean 105.0 mmHg 2.0 6.0 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96871 1719
SS.LEW-(D3Rat52-D3Chm63)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 7 146.0 mmHg 6.0 15.87 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84477 1438
SS.LEW-(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 109.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84485 1438
SS.LEW-(D2Uia5-D2Mit6)(D3Rat17-D3Mco80)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 116.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84499 1438
SS.LEW-(D1Rat320-D1Mgh32)(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 6 109.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84501 1438
SS.MNS-(D2Chm90-D2Rat38),LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 133.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84504 1438
SS.LEW-(D10Chm280-D10Chm216)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 105 days) Crespo K, et al., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e. arterial blood pressure trait male 66 days-86 days 12 serial mean 149.0 mmHg 1.15 4.0 intra-aortic abdominal radiotelemetry 2.0 0 for 2 wks has records that will be duplicated if entered need to add multiple refs once the functionality is in 96579 1665
LEW.SS-(D17Rat15-D17Rat51)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 41 days) Crespo K, et al., Circ Cardiovasc Genet. 2015 Aug;8(4):610-7. doi: 10.1161/CIRCGENETICS.114.000965. Epub 2015 May 11. arterial blood pressure trait male 67 days-77 days 5 89.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 864000.0 0 97143 1878
LEW.SS-(D7Rat27-D7Mgh1)(D17Rat15-D17Rat51)(D10Mgh6-D10Mgh1)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 41 days) Crespo K, et al., Circ Cardiovasc Genet. 2015 Aug;8(4):610-7. doi: 10.1161/CIRCGENETICS.114.000965. Epub 2015 May 11. arterial blood pressure trait male 67 days-77 days 5 105.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 864000.0 0 97145 1878
SS-Clcn6em2Mcwi heart rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. heart pumping trait male 58 days-67 days 0 serial mean 337.0 beats/min 6.0 intra-aortic abdominal radiotelemetry 32400.0 0 98421 2059
GK systolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 5 134.0 mmHg 4.0 8.94 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 1 week daytime measurement 103525 2827
WKY/NCrl systolic blood pressure salidroside (40 mg/kg) (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 117.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103527 2827
GK systolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 145.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103528 2827
WKY/NCrl systolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 6 126.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103530 2827
WKY/NCrl number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and dark phase of controlled light/dark cycle Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 2.8 /min 0.3 0.73 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103582 2827
GK systolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 5 143.0 mmHg 4.0 8.94 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103533 2827
WKY/NCrl systolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 126.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103534 2827
GK systolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 145.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103536 2827
WKY/NCrl diastolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 6 85.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/day for 1 week daytime measurement 103538 2827
GK diastolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 104.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103552 2827
GK heart rate control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 130 days-140 days 6 272.0 beats/min 2.0 4.9 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/day for 1 week daytime measurement 103556 2827
WKY/NCrl heart rate control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 133 days-140 days 6 337.0 beats/min 3.0 7.35 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103563 2827
WKY/NCrl number of spontaneous locomotor movements per unit time control condition and dark phase of controlled light/dark cycle (for 3 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 140 days 6 3.1 /min 0.3 0.73 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night number of spontaneous locomotor movements per unit time (CMO:0003644) 103578 2827
SS-Renem1Mcwi+/- diastolic blood pressure controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. arterial blood pressure trait male 66 days-69 days 9 serial mean 93.33 mmHg 1.98 5.94 intra-aortic abdominal radiotelemetry 32400.0 0 98378 2038
Crl:WI diastolic blood pressure control condition Stepp DW, et al., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13. arterial blood pressure trait male 70 days-126 days 8 every 10 min for 24hr 92.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 0.0 0 105538 3017
WI-Mc4rm1Hubr diastolic blood pressure control condition Stepp DW, et al., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13. arterial blood pressure trait male 70 days-126 days 8 every 10 min for 24hr 94.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 0.0 0 105539 3017
SS.SHR-(D9Wox16-D9Rat64)/Mco heart rate controlled sodium content diet (2 %) (for 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart pumping trait male 75 days-79 days 5 396.0 beats/min 8.72 19.5 intra-aortic abdominal radiotelemetry 172800 0 64987 305
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 159.4 mmHg 5.0 8.66 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65617 613
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 229.8 mmHg 7.3 12.64 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65651 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 108.5 mmHg 3.6 6.24 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65680 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 118.2 mmHg 5.6 9.7 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65703 613
SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 9 and 10 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 76 days-78 days 5 157.7 mmHg 2.3 5.14 intra-aortic abdominal radiotelemetry 86400 0 65046 283
WKY/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 4 continuous mean 132.1 mmHg 7.9 15.8 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65599 613
SS.LEW-(D16Mit2-D16Rat12)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 36 days) Moujahidine M, et al., Mamm Genome 2002 Mar;13(3):153-6. arterial blood pressure trait male 56 days-71 days 4 serial mean 149.0 mmHg 2.0 4.0 intra-aortic abdominal radiotelemetry aorta 0 0 average of 6 measurements taken every 4 hrs 13077 328
LEW.SS-(D2Uia5-D2Rat143)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 5 91.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry aorta 0 12587 269
SHRSP/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 166.5 mmHg 3.8 6.58 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65582 613
SS.SR-(D13Mit9-D13Mit1)/Jr systolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 8 serial mean 136.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11703 119
SS.SR-(rs65785750-rs106808193)/Opaz pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 8 52.03 mmHg 1.4 3.96 intra-aortic abdominal radiotelemetry 0.0 0 70362 1358
SS.LEW-(D16Chm48-D16Chm60)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 7 149.0 mmHg 2.0 5.29 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70438 1438
SS/Jr absolute change in heart rate sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 43 days-50 days 0 54.0 beats/min 6.0 intra-aortic abdominal radiotelemetry 0.0 0 69698 344
SS.LEW-(D18Chm59-D18Rat1)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 142.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84484 1438
SS.LEW-(D10Rat11-D10Mgh1)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 6 180.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67880 830
SS.MNS-(D2Mit6-D2Rat303)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 167.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70475 1438
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 67 days-77 days 10 serial mean 127.0 mmHg 1.0 3.16 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96862 1718
SS/Jr absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 13.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 68142 344
SS.LEW-(D3Rat2-D3Chm79)(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 12 136.0 mmHg 3.0 10.39 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84492 1438
SS.LEW-(D17Chm131-D17Chm93)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 146.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84494 1438
SS.MNS-(D2Chm33-Tm2sf1),LEW-(D10Rat194-D10Chm243),LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 148.0 mmHg 9.0 20.12 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84508 1438
SS.MNS-(D2Chm33-Tm2sf1),LEW-(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 7 131.0 mmHg 3.0 7.94 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84510 1438
SS.MNS-(D2Chm90-D2Rat38)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 10 138.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70481 1438
SS.LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 16 150.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70489 1438
SS.LEW-(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 148.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70491 1438
SS.LEW-(D17Chm14-D17Rat181)/Ayd absolute change in heart rate sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 42.0 beats/min 3.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69736 344
SS.BN-(D12Hmgc3- D12Got29)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) then controlled sodium content diet (8 %) (for 21 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 92 days-98 days 5 141.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry 0.0 0 96809 1698
SS-Nppbem2Mcwi-/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 133.0 mmHg 2.0 intra-aortic abdominal radiotelemetry 32400.0 0 98398 2059
SS-Renem1Mcwi+/+ heart rate controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. heart pumping trait female 66 days-69 days 7 serial mean 386.01 beats/min 5.71 15.11 intra-aortic abdominal radiotelemetry 32400.0 0 98394 2038
SS-Nppbem2Mcwi-/- systolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 155.0 mmHg 2.0 intra-aortic abdominal radiotelemetry 32400.0 0 98412 2059
LEW/Crl mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 46 days) Crespo K, et al., Circ Cardiovasc Genet. 2015 Aug;8(4):610-7. doi: 10.1161/CIRCGENETICS.114.000965. Epub 2015 May 11. arterial blood pressure trait male 67 days-82 days 9 98.0 mmHg 2.0 6.0 intra-aortic abdominal radiotelemetry abdominal aorta 1296000.0 0 97142 1878
SS.LEW-(D1Rat211-D1Rat18)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 171.0 mmHg 3.4 9.62 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65498 611
SS.LEW-(D1Rat211-D1Rat18)/Mco diastolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 123.0 mmHg 2.9 8.2 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65499 611
WKY/Gcrc diastolic blood pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 124 days-128 days 6 continuous mean 99.5 mmHg 1.96 4.8 intra-aortic abdominal radiotelemetry abdominal aorta 0 11627 109
WKY/Gcrc pulse pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 124 days-128 days 6 continuous mean 42.6 mmHg 1.1 2.7 intra-aortic abdominal radiotelemetry abdominal aorta 0 11631 109
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 137 days-140 days 6 continuous mean 168.7 mmHg 2.25 5.5 intra-aortic abdominal radiotelemetry abdominal aorta 0 11633 109
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 147.1 mmHg 3.76 9.2 intra-aortic abdominal radiotelemetry abdominal aorta 0 11634 109
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 150.5 mmHg 4.45 10.9 intra-aortic abdominal radiotelemetry abdominal aorta 0 11635 109
SHRSP/Gcrc pulse pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 63.8 mmHg 1.63 4.0 intra-aortic abdominal radiotelemetry abdominal aorta 0 11638 109
WKY/Gcrc pulse pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 137 days-140 days 6 continuous mean 52.9 mmHg 1.51 3.7 intra-aortic abdominal radiotelemetry abdominal aorta 0 11639 109
SR/Jr systolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 144.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11695 119
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 117.8 mmHg 3.3 5.72 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65613 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 122.8 mmHg 4.5 7.79 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65618 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 130.2 mmHg 4.1 7.1 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65625 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 111.6 mmHg 4.4 7.62 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65637 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 116.3 mmHg 6.4 11.09 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65639 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 113.5 mmHg 1.3 2.25 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65647 613
WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 10 96.86 mmHg 1.09 3.45 intra-aortic abdominal radiotelemetry 0 12662 281
SS.SHR-(D9Wox16-D9Rat64)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 147.0 mmHg 1.56 3.49 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13027 305
SS.SHR-(D9Mco74-D9Rat64)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 156.0 mmHg 1.73 3.87 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13028 305
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 176.8 mmHg 6.3 10.91 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65689 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 163.0 mmHg 3.8 6.58 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65699 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 105.4 mmHg 6.3 10.91 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65705 613
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 167.2 mmHg 5.2 9.01 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65655 613
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 188.1 mmHg 5.9 10.22 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65659 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 131.2 mmHg 5.5 9.53 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65678 613
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 27 and 28 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 67 days-69 days 5 181.0 mmHg 3.6 8.05 intra-aortic abdominal radiotelemetry 86400 0 65041 283
SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 27 and 28 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 67 days-69 days 5 137.8 mmHg 1.6 3.58 intra-aortic abdominal radiotelemetry 86400 0 65042 283
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 47 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 114 days-116 days 3 219.3 mmHg 4.2 7.27 intra-aortic abdominal radiotelemetry 86400 0 65050 283
SS.SR-(D3Arb14-D3Mco36)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 79 and 80 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 147 days-149 days 2 228.2 mmHg 3.0 4.24 intra-aortic abdominal radiotelemetry 86400 0 65054 283
SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 39 and 40 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 107 days-109 days 4 148.8 mmHg 4.1 8.2 intra-aortic abdominal radiotelemetry 86400 0 65065 283
SS.LEW-(D17Chm9-D17Rat97)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 43 and 47 days) Grondin M, et al., Physiol Genomics 2005 Mar 21;21(1):112-6. Epub 2005 Jan 4. arterial blood pressure trait male 88 days-92 days 10 170.0 mmHg 7.0 22.14 intra-aortic abdominal radiotelemetry 0 measure every 2 min for 24 hrs 12474 261
SS.LEW-(D17Chm14-D17Rat97)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 43 and 47 days) Grondin M, et al., Physiol Genomics 2005 Mar 21;21(1):112-6. Epub 2005 Jan 4. arterial blood pressure trait male 88 days-92 days 7 172.0 mmHg 5.0 13.23 intra-aortic abdominal radiotelemetry 0 measure every 2 min for 24 hrs 12476 261
SS.LEW-(D18Chm31-D18Rat55)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 7 131.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry aorta 0 12603 269
SS.LEW-(D18Rat67-D18Rat55)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 6 132.0 mmHg 8.0 19.6 intra-aortic abdominal radiotelemetry aorta 0 12608 269
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 10 170.0 mmHg 5.0 15.81 intra-aortic abdominal radiotelemetry 0 12322 242
LEW mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 6 serial mean 95.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12736 304
SS.LEW-(D10Chm155-D10Rat127)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 8 serial mean 148.0 mmHg 6.0 16.97 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12740 304
SS.LEW-(D10Chm167-D10Chm257)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 5 serial mean 145.0 mmHg 6.0 13.42 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12744 304
SS.SR-(D13Mit9-D13Mit1)/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 89.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11709 119
SS.SR-(D13Mit9-D13Mit1)/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 82.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11710 119
SS.LEW-(D16Uia2-D16Rat12)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 36 days) Moujahidine M, et al., Mamm Genome 2002 Mar;13(3):153-6. arterial blood pressure trait male 56 days-71 days 4 serial mean 158.0 mmHg 3.0 6.0 intra-aortic abdominal radiotelemetry aorta 0 0 average of 6 measurements taken every 4 hrs 13075 328
SS.SHR-(D9Mco74-D9Rat64)/Mco heart rate controlled sodium content diet (2 %) (for 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. heart pumping trait male 75 days-79 days 5 398.0 beats/min 9.49 21.22 intra-aortic abdominal radiotelemetry 172800 0 64988 305
SHRSP/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 161.8 mmHg 3.0 5.2 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65580 613
SHRSP/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 113.6 mmHg 2.2 3.81 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65584 613
SHRSP/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 135.7 mmHg 3.1 5.37 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65589 613
WKY/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 4 continuous mean 91.2 mmHg 6.0 12.0 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65594 613
LEW/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 49 days) Crespo K, et al., J Hypertens. 2011 Mar;29(3):460-5. arterial blood pressure trait male 66 days-73 days 8 95.0 mmHg 6.0 16.97 intra-aortic abdominal radiotelemetry 0 0 65144 563
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 49 days) Crespo K, et al., J Hypertens. 2011 Mar;29(3):460-5. arterial blood pressure trait male 66 days-73 days 14 178.0 mmHg 4.0 14.97 intra-aortic abdominal radiotelemetry 0 0 65147 563
SS.LEW-(D10Rat27-Igfbp4)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 7 150.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67879 830
SS.LEW-(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 10 151.0 mmHg 3.0 9.49 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70435 1438
SS.LEW-(D5Mit5-D5M4Mit14)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 9 180.0 mmHg 8.0 24.0 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70473 1438
SS.MNS-(D2Wox27-Adh1)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 162.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70478 1438
SS mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 18 173.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70467 1438
LEW/Crlc absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 8.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 68139 344
SS.MNS-(D2Rat183-D2Chm113)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 14 145.0 mmHg 3.0 11.22 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70460 1438
SS/JrHsd pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 8 57.1 mmHg 0.4 1.13 intra-aortic abdominal radiotelemetry 0.0 0 70504 1458
SS/Jr absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 23.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69729 344
SS.LEW-(D10Chm10-D10Rat11)/Ayd percent change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 12.0 % 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion % change map 69731 344
SS.LEW-(D10Chm10-D10Rat11)/Ayd change in heart rate to change in mean arterial blood pressure ratio sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 -2.2 beats/min/mmHg 0.1 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion average slope, bpm/mm Hg 69747 344
SS.MNS-(D2Rat183-D2Chm113)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 12 136.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70480 1438
SS.SR-(rs106870553-rs63922710)/Opaz systolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 10 187.0 mmHg 3.0 9.49 intra-aortic abdominal radiotelemetry 0.0 0 70566 1458
SR/JrHsd diastolic blood pressure controlled sodium content diet (8 %) (between 55 and 56 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait male 139 days-140 days 5 93.4 mmHg 1.61 3.6 intra-aortic abdominal radiotelemetry 0.0 0 67870 810
SS.SR-(D2Rat352-rs63922710)/Opaz systolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 6 180.8 mmHg 3.7 9.06 intra-aortic abdominal radiotelemetry 0.0 0 70562 1458
SS.SR-(D2Rat352-rs63922710)/Opaz mean arterial blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 6 153.7 mmHg 3.1 7.59 intra-aortic abdominal radiotelemetry 0.0 0 70564 1458
SS.LEW-(D7Rat73-D7Rat128)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 6 138.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70454 1438
SS mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 12 183.0 mmHg 4.0 13.86 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70469 1438
SS.LEW-(D17Rat84-D17Chm17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 137.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70496 1438
SS.MNS-(D2Rat155-D2Chm161)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 105 days) Crespo K, et al., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e. arterial blood pressure trait male 66 days-86 days 9 serial mean 125.0 mmHg 2.0 6.0 intra-aortic abdominal radiotelemetry 2.0 0 for 2 wks has records that will be duplicated if entered need to add multiple refs once the functionality is in 96581 1665
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) then controlled sodium content diet (8 %) (for 7 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 74 days-84 days 10 serial mean 144.0 mmHg 6.0 18.97 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96863 1718
SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) then controlled sodium content diet (8 %) (for 7 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 74 days-84 days 11 serial mean 178.0 mmHg 7.0 23.22 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96869 1718
SS.BN-(D12Hmgc3-AU047911)/Mcwi mean arterial blood pressure controlled sodium content diet (0.3 %) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. arterial blood pressure trait male 66 days-73 days 8 serial mean 106.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96872 1719
ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Eur mean arterial blood pressure right nephrectomy (for 35 days) then controlled sodium content diet (0.4 %) (for 35 days) O'Meara CC, et al., J Am Soc Nephrol. 2011 Mar;22(3):518-25. Epub 2010 Dec 2. arterial blood pressure trait male 70 days-77 days 6 serial mean 111.08 mmHg 2.04 5.0 intra-aortic abdominal radiotelemetry 259200.0 right nephrectomy 35 days 10 s every 2 m for 3 h 84745 1600
SS.LEW-(D10Rat194-D10Chm243)(D16Chm48-D16Chm60)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 150.0 mmHg 9.0 25.46 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84487 1438
SS.LEW-(D17Chm131-D17Chm93)(D17Rat84-D17Chm17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 7 144.0 mmHg 6.0 15.87 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84495 1438
SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 71 days-77 days 14 110.0 mmHg 2.0 7.48 intra-aortic abdominal radiotelemetry 0.0 0 96801 1698
SS.BN-(D12Hmgc3- D12Got29)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 71 days-77 days 5 107.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry 0.0 0 96808 1698
SS-Plod1em1Mcwi-/- systolic blood pressure controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 165.0 mmHg 4.0 intra-aortic abdominal radiotelemetry 32400.0 0 98411 2059
SS/Hsd heart rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. heart pumping trait male 58 days-67 days 0 serial mean 339.0 beats/min 4.0 intra-aortic abdominal radiotelemetry 32400.0 0 98424 2059
WKY/NCrl systolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 6 121.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 1 week daytime measurement 103522 2827
GK systolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 6 135.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 1 week daytime measurement 103524 2827
WKY/NCrl systolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 121.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103526 2827
WKY/NCrl systolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 6 122.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103531 2827
WKY/NCrl number of spontaneous locomotor movements per unit time salidroside (40 mg/kg) (between 1 and 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 3.4 /min 0.3 0.73 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103583 2827
WKY/NCrl heart rate control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 130 days-140 days 6 290.0 beats/min 4.0 9.8 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/day for 1 week daytime measurement 103554 2827
WKY/NCrl heart rate control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 130 days-140 days 6 280.0 beats/min 3.0 7.35 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/day for 1 week daytime measurement 103555 2827
GK heart rate vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 279.0 beats/min 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103560 2827
WKY/NCrl heart rate control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 133 days-140 days 6 347.0 beats/min 6.0 14.7 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103562 2827
GK heart rate control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 133 days-140 days 5 339.0 beats/min 15.0 33.54 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103565 2827
WKY/NCrl heart rate salidroside (40 mg/kg) (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 334.0 beats/min 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103567 2827
GK heart rate salidroside (40 mg/kg) (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 5 339.0 beats/min 14.0 31.3 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103569 2827
WKY/NCrl number of spontaneous locomotor movements per unit time control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 140 days 6 1.0 /min 0.1 0.24 intra-aortic abdominal radiotelemetry 0.0 0 number of spontaneous locomotor movements per unit time (CMO:0003644) 103571 2827
GK number of spontaneous locomotor movements per unit time control condition and dark phase of controlled light/dark cycle (for 3 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 140 days 6 3.6 /min 0.2 0.49 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night number of spontaneous locomotor movements per unit time (CMO:0003644) 103580 2827
SS-Renem1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. arterial blood pressure trait male 66 days-69 days 5 serial mean 125.46 mmHg 2.07 4.63 intra-aortic abdominal radiotelemetry 32400.0 0 98374 2038
SS-Renem1Mcwi-/- mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. arterial blood pressure trait male 66 days-69 days 8 serial mean 58.36 mmHg 2.38 6.73 intra-aortic abdominal radiotelemetry 32400.0 0 98380 2038
SS-Renem1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. arterial blood pressure trait female 66 days-69 days 7 serial mean 112.8 mmHg 3.55 9.39 intra-aortic abdominal radiotelemetry 32400.0 0 98383 2038
SS-Renem1Mcwi+/+ diastolic blood pressure controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. arterial blood pressure trait female 66 days-69 days 7 serial mean 89.42 mmHg 3.12 8.25 intra-aortic abdominal radiotelemetry 32400.0 0 98384 2038
SS-Agtrapem4Mcwi-/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 131.0 mmHg 3.0 intra-aortic abdominal radiotelemetry 32400.0 0 98402 2059
SS-Nppaem4Mcwi-/- diastolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 143.0 mmHg 5.0 intra-aortic abdominal radiotelemetry 32400.0 0 98406 2059
SS-Mthfrem1Mcwi-/+ diastolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 110.0 mmHg 4.0 intra-aortic abdominal radiotelemetry 32400.0 0 98408 2059
Crl:WI mean arterial blood pressure control condition Stepp DW, et al., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13. arterial blood pressure trait male 70 days-126 days 8 night every 10 min 111.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 0.0 0 105544 3017
Crl:WI mean arterial blood pressure control condition Stepp DW, et al., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13. arterial blood pressure trait male 70 days-126 days 8 every 10 min for 24hr 108.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 0.0 0 105536 3017
WI-Mc4rm1Hubr mean arterial blood pressure control condition Stepp DW, et al., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13. arterial blood pressure trait male 70 days-126 days 8 night every 10 min 114.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 0.0 0 105545 3017
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 138.9 mmHg 2.6 4.5 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65665 613
SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (between 27 and 28 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 67 days-69 days 5 95.1 mmHg 1.6 3.58 intra-aortic abdominal radiotelemetry 86400 0 65058 283
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 39 and 40 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 107 days-109 days 3 164.9 mmHg 2.3 3.98 intra-aortic abdominal radiotelemetry 86400 0 65063 283
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 46 and 47 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 114 days-116 days 3 158.2 mmHg 3.9 6.75 intra-aortic abdominal radiotelemetry 86400 0 65066 283
WKY/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 117.7 mmHg 7.5 15.0 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65671 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 167.6 mmHg 5.5 9.53 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65688 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 126.6 mmHg 4.8 8.31 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65706 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 99.5 mmHg 1.2 2.08 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65714 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 91.9 mmHg 7.4 12.82 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65717 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 118.9 mmHg 2.6 4.5 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65607 613
SS.SHR-(D9Wox16-D9Rat64)/Mco diastolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 103.0 mmHg 1.15 2.57 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13032 305
SS.LEW-(D18Chm41-D18Rat45)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 5 130.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry aorta 0 12597 269
ACI.FHH-(D1Mit18-D1Rat90)(D3Rat6-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi mean arterial blood pressure right nephrectomy (for 35 days) then controlled sodium content diet (0.4 %) (for 35 days) O'Meara CC, et al., J Am Soc Nephrol. 2011 Mar;22(3):518-25. Epub 2010 Dec 2. arterial blood pressure trait male 70 days-77 days 7 serial mean 110.82 mmHg 3.45 9.13 intra-aortic abdominal radiotelemetry 259200.0 right nephrectomy 35 days 10 s every 2 m for 3 h 84744 1600
SS.LEW-(D10Chm10-D10Rat11)/Ayd percent change in heart rate sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 43 days-50 days 0 11.0 % 3.0 intra-aortic abdominal radiotelemetry 0.0 0 69700 344
SS/Jr percent change in heart rate sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 43 days-50 days 0 10.0 % 1.0 intra-aortic abdominal radiotelemetry 0.0 0 69702 344
SS.LEW-(D17Chm85-D17Chm71)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 10 168.0 mmHg 5.0 15.81 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70494 1438
SS.SR-(D2Rat352-rs63922710)/Opaz pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 6 50.0 mmHg 1.0 2.45 intra-aortic abdominal radiotelemetry 0.0 0 70561 1458
SS.SR-(rs106870553-rs63922710)/Opaz mean arterial blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 10 159.6 mmHg 2.8 8.85 intra-aortic abdominal radiotelemetry 0.0 0 70567 1458
SS-Chr 12BN.SS-(D12Arb13-D12Mit2)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) then controlled sodium content diet (8 %) (for 7 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 74 days-84 days 8 serial mean 136.0 mmHg 5.0 14.14 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96865 1718
SS.LEW-(D10Chm10-D10Rat11)/Ayd absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 43 days-51 days 0 9.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 68136 344
SS/Jr absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 43 days-51 days 0 17.0 mmHg 2.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 68138 344
SS.LEW-(D3Chm64-D3Rat17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 195.0 mmHg 9.0 25.46 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84478 1438
SS/JrHsd mean arterial blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 8 181.7 mmHg 2.2 6.22 intra-aortic abdominal radiotelemetry 0.0 0 70503 1458
LEW/Crlc percent change in heart rate sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 7.0 % 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69738 344
SS.BN-(D12Hmgc7-D12Hmgc6)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 71 days-77 days 6 110.0 mmHg 1.0 2.45 intra-aortic abdominal radiotelemetry 0.0 0 96806 1698
SS-Renem1Mcwi-/- systolic blood pressure controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. arterial blood pressure trait male 66 days-69 days 4 serial mean 76.38 mmHg 2.94 5.88 intra-aortic abdominal radiotelemetry 32400.0 0 98388 2038
SS-Clcn6em2Mcwi diastolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 101.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 32400.0 0 98407 2059
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 103.5 mmHg 3.0 5.2 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65609 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 178.0 mmHg 5.0 8.66 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65614 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 125.8 mmHg 3.3 5.72 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65624 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 137.9 mmHg 2.6 4.5 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65638 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 141.5 mmHg 2.0 3.46 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65640 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 120.4 mmHg 8.1 14.03 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65641 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 87.4 mmHg 4.5 7.79 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65645 613
SHRSP/Gcrc diastolic blood pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 124 days-128 days 6 continuous mean 140.8 mmHg 2.61 6.4 intra-aortic abdominal radiotelemetry abdominal aorta 0 11625 109
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 101.2 mmHg 3.02 7.4 intra-aortic abdominal radiotelemetry abdominal aorta 0 11637 109
SR/Jr systolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 128.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11699 119
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 89.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11701 119
WKY/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 20 84.45 mmHg 0.68 3.04 intra-aortic abdominal radiotelemetry 0 0 12656 281
WKY.SHRSP-(D1Rat200-D1Rat216)/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 12 92.94 mmHg 1.11 3.85 intra-aortic abdominal radiotelemetry 0 12658 281
WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 10 136.96 mmHg 1.91 6.04 intra-aortic abdominal radiotelemetry 0 12661 281
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 173.4 mmHg 3.9 6.75 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65652 613
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 136.6 mmHg 8.2 16.4 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65662 613
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 104.4 mmHg 6.9 13.8 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65667 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 191.2 mmHg 3.4 5.89 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65675 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 154.9 mmHg 3.7 6.41 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65676 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 147.8 mmHg 4.3 7.45 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65682 613
SS/Jr systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 39 and 40 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 107 days-109 days 3 228.2 mmHg 2.6 4.5 intra-aortic abdominal radiotelemetry 86400 0 65047 283
SS.SR-(D3Arb14-D3Mco36)/Mco diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 39 and 40 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 107 days-109 days 4 157.5 mmHg 3.3 6.6 intra-aortic abdominal radiotelemetry 86400 0 65064 283
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 221.3 mmHg 15.4 26.67 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65687 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 120.0 mmHg 6.6 11.43 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65709 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 130.6 mmHg 8.2 14.2 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65713 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 108.4 mmHg 1.4 2.42 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65715 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 115.0 mmHg 1.5 2.6 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65718 613
SS.LEW-(D17Rat65-D17Chm2)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 43 and 47 days) Grondin M, et al., Physiol Genomics 2005 Mar 21;21(1):112-6. Epub 2005 Jan 4. arterial blood pressure trait male 88 days-92 days 5 173.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry 0 measure every 2 min for 24 hrs 12472 261
SS.LEW-(D18Chm91-D18Rat67)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 5 142.0 mmHg 4.0 8.94 intra-aortic abdominal radiotelemetry aorta 0 12601 269
SS.LEW-(D10Chm224-D10Chm259)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 6 serial mean 131.0 mmHg 6.0 14.7 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12747 304
SS.SHR-(D9Mco72-D9Mco93)/Mco diastolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 103.0 mmHg 1.14 2.55 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13034 305
SS.SR-(D13Mit9-D13Mit1)/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 8 serial mean 102.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11705 119
SS.LEW-(D10Mco30-D10Got107)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 5 serial mean 168.0 mmHg 6.0 13.42 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12738 304
SS.LEW-(D10Rat24-Igfbp4)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 7 serial mean 177.0 mmHg 6.0 15.87 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12739 304
SS.SR-(D13Mit9-D13Mit1)/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 8 serial mean 89.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11706 119
WKY/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 20 126.13 mmHg 0.55 2.46 intra-aortic abdominal radiotelemetry 0 0 12654 281
SS.LEW-(D2Rat199-D2Mco17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 8 205.0 mmHg 3.0 8.49 intra-aortic abdominal radiotelemetry aorta 0 12586 269
SHRSP/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 130.0 mmHg 1.2 2.08 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65583 613
WKY/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 4 continuous mean 107.7 mmHg 6.9 13.8 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65591 613
WKY/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 92.0 mmHg 3.4 5.89 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65597 613
LEW.SS-(D7Rat73-D7Rat128)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 49 days) Crespo K, et al., J Hypertens. 2011 Mar;29(3):460-5. arterial blood pressure trait male 66 days-73 days 6 93.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0 0 65149 563
SS.LEW-(D10Mco1-D10Mco31)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 7 139.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67882 830
SS.LEW-(D10Mco30-D10Got92)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 5 185.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67886 830
SS.LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 7 150.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67887 830
SR/JrHsd systolic blood pressure controlled sodium content diet (8 %) (between 83 and 84 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait female 167 days-168 days 5 120.8 mmHg 3.4 7.6 intra-aortic abdominal radiotelemetry 0.0 0 67858 810
SS.LEW-(D8Chm14-D8Rat16)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 7 138.0 mmHg 5.0 13.23 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70441 1438
SS.LEW-(D17Chm131-D17Chm93)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 129.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70443 1438
SS.LEW-(D2Rat199-D2Mco17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 199.0 mmHg 4.0 11.31 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70446 1438
SS mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 12 172.0 mmHg 4.0 13.86 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70470 1438
SS.LEW-(D1Uia4-D1Rat320)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 130.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70462 1438
SS/JrHsd diastolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 8 154.7 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 0.0 0 70502 1458
SS.LEW-(D10Chm10-D10Rat11)/Ayd absolute change in heart rate sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 31.0 beats/min 3.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69735 344
SS/Jr maximum change in heart rate to change in mean arterial blood pressure ratio sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 -1.8 beats/min/mmHg 0.2 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion Maximum slope, bpm/mm Hg 69745 344
SS/Jr change in heart rate to change in mean arterial blood pressure ratio sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 -1.6 beats/min/mmHg 0.2 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion average slope, bpm/mm Hg 69749 344
SS.LEW-(D10Rat27-Igfbp4)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 148.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70488 1438
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 16 177.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 68086 830
SS/JrHsd diastolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 9 139.7 mmHg 5.8 17.4 intra-aortic abdominal radiotelemetry 0.0 0 70354 1358
SS/JrHsd mean arterial blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 9 165.9 mmHg 5.9 17.7 intra-aortic abdominal radiotelemetry 0.0 0 70357 1358
SS/JrHsd pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 9 54.74 mmHg 0.8 2.4 intra-aortic abdominal radiotelemetry 0.0 0 70360 1358
SS.MNS-(D2Rat155-D2Chm419)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 9 124.0 mmHg 6.0 18.0 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70457 1438
SS.SR-(D2Rat352-rs63922710)/Opaz diastolic blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait female 108 days-112 days 6 118.5 mmHg 2.2 5.39 intra-aortic abdominal radiotelemetry 0.0 0 70560 1458
SS.LEW-(D10Rat119-D10Rat133)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 6 183.0 mmHg 9.0 22.05 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84479 1438
LEW/Crlc absolute change in heart rate sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 43 days-50 days 0 38.0 beats/min 4.0 intra-aortic abdominal radiotelemetry 0.0 0 69695 344
SS.SR-(D2Rat352-rs63922710)/Opaz pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2013 Jul 4;8(7):e67673. doi: 10.1371/journal.pone.0067673. Print 2013. arterial blood pressure trait male 108 days-112 days 6 51.8 mmHg 2.3 5.63 intra-aortic abdominal radiotelemetry 0.0 0 70565 1458
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 67 days-77 days 12 serial mean 121.0 mmHg 3.0 10.39 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96860 1718
SS-Chr 12BN.SS-(D12Arb13-D12Mit2)/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 67 days-77 days 8 serial mean 114.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96864 1718
SS.LEW-(D16Chm48-D16Chm60)(D18Rat101-D18Rat92)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 141.0 mmHg 4.0 8.94 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84498 1438
SS.MNS-(D2Rat155-D2Chm419),LEW-(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 135.0 mmHg 5.0 11.18 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84506 1438
SS.MNS-(D2Rat155-D2Chm419),LEW-(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 125.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84507 1438
SS.MNS-(D2Chm33-Tm2sf1),LEW-(D3Rat2-D3Chm79)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 9 117.0 mmHg 2.0 6.0 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84511 1438
SS-Plod1em1Mcwi-/- heart rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. heart pumping trait male 58 days-67 days 0 serial mean 351.0 beats/min 5.0 intra-aortic abdominal radiotelemetry 32400.0 0 98418 2059
SS-Nppbem2Mcwi-/- heart rate controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. heart pumping trait male 58 days-67 days 0 serial mean 352.0 beats/min 10.0 intra-aortic abdominal radiotelemetry 32400.0 0 98419 2059
GK systolic blood pressure salidroside (40 mg/kg) (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 5 139.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103529 2827
GK diastolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 6 96.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/day for 1 week daytime measurement 103540 2827
GK diastolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 5 95.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/day for 1 week daytime measurement 103541 2827
WKY/NCrl diastolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 85.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103542 2827
WKY/NCrl diastolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 6 89.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103546 2827
GK diastolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133 days-140 days 5 104.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103549 2827
GK heart rate control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 130 days-140 days 5 278.0 beats/min 5.0 11.18 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/day for 1 week daytime measurement 103557 2827
GK heart rate control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 133 days-140 days 6 324.0 beats/min 7.0 17.15 intra-aortic abdominal radiotelemetry 0.0 0 measured 12 hr/night for 1 week nighttime measurement 103564 2827
WKY/NCrl heart rate vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 344.0 beats/min 5.0 12.25 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103566 2827
WKY/NCrl number of spontaneous locomotor movements per unit time control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 140 days 6 1.0 /min 0.2 0.49 intra-aortic abdominal radiotelemetry 0.0 0 number of spontaneous locomotor movements per unit time (CMO:0003644) 103570 2827
WKY/NCrl number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 0.9 /min 0.1 0.24 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103574 2827
GK number of spontaneous locomotor movements per unit time salidroside (40 mg/kg) (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 5 1.0 /min 0.1 0.22 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103577 2827
SS-Nppaem4Mcwi-/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 163.0 mmHg 6.0 intra-aortic abdominal radiotelemetry 32400.0 0 98399 2059
SS-Clcn6em2Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 123.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 32400.0 0 98400 2059
SS-Plod1em1Mcwi-/- diastolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 126.0 mmHg 5.0 intra-aortic abdominal radiotelemetry 32400.0 0 98404 2059
SS-Agtrapem4Mcwi-/- diastolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 120.0 mmHg 5.0 intra-aortic abdominal radiotelemetry 32400.0 0 98409 2059
SS-Renem1Mcwi+/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. arterial blood pressure trait female 66 days-69 days 8 serial mean 115.55 mmHg 1.5 4.24 intra-aortic abdominal radiotelemetry 32400.0 0 98386 2038
SS-Renem1Mcwi-/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. arterial blood pressure trait female 66 days-69 days 4 serial mean 61.59 mmHg 2.87 5.74 intra-aortic abdominal radiotelemetry 32400.0 0 98389 2038
SS-Renem1Mcwi+/- heart rate controlled sodium content diet (0.4 %) (between 66 and 69 days) Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. heart pumping trait male 66 days-69 days 9 serial mean 357.55 beats/min 5.0 15.0 intra-aortic abdominal radiotelemetry 32400.0 0 98392 2038
Crl:WI systolic blood pressure control condition Stepp DW, et al., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13. arterial blood pressure trait male 70 days-126 days 8 every 10 min for 24hr 129.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 0.0 0 105540 3017
Crl:WI heart rate control condition Stepp DW, et al., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13. heart pumping trait male 70 days-126 days 8 354.0 beats/min 4.0 11.31 intra-aortic abdominal radiotelemetry 0.0 0 105546 3017
Crl:WI mean arterial blood pressure control condition Stepp DW, et al., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13. arterial blood pressure trait male 70 days-126 days 8 day every 10 min 110.0 mmHg 3.0 8.49 intra-aortic abdominal radiotelemetry 0.0 0 105542 3017
SS.SR-(D13Mit9-D13Mit1)/Jr systolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 8 serial mean 127.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11704 119
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 115.0 mmHg 2.6 4.5 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65612 613
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 152.9 mmHg 5.2 9.01 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65654 613
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 139.0 mmHg 3.4 5.89 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65660 613
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 92.0 mmHg 2.9 5.02 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65668 613
SHRSP/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 134.8 mmHg 1.3 2.25 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65611 613
SS.SR-(D3Arb14-D3Mco36)(D7Mco19-D7Mco7)/Mco systolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 79 and 80 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 147 days-149 days 2 234.4 mmHg 4.1 5.8 intra-aortic abdominal radiotelemetry 86400 0 65055 283
SS/Jr diastolic blood pressure controlled sodium content diet (0.3 %) (between 10 and 12 days) then controlled sodium content diet (2 %) (for 28 days) then controlled sodium content diet (4 %) (between 9 and 10 days) Cicila GT, et al., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2. arterial blood pressure trait male 76 days-78 days 4 153.0 mmHg 1.6 3.2 intra-aortic abdominal radiotelemetry 86400 0 65060 283
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 140.7 mmHg 8.0 13.86 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65700 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 112.1 mmHg 7.2 12.47 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65708 613
SS.SR-(D13Mit9-D13Mit1)/Jr systolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 118.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11708 119
SHRSP/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 148.4 mmHg 1.0 1.73 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65587 613
WKY/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 104.0 mmHg 3.4 5.89 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65593 613
SS.LEW-(D18Chm41-D18Rat92)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 5 124.0 mmHg 4.0 8.94 intra-aortic abdominal radiotelemetry aorta 0 12600 269
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 158.0 mmHg 1.76 3.94 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13035 305
SR/JrHsd diastolic blood pressure controlled sodium content diet (8 %) (between 83 and 84 days) Herrera VL, et al., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23. arterial blood pressure trait female 167 days-168 days 5 84.2 mmHg 1.97 4.4 intra-aortic abdominal radiotelemetry 0.0 0 67872 810
SS.LEW-(D10Chm128-D10Chm169)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 8 184.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67883 830
SS.LEW-(D10Rat204-D10Rat9)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14. arterial blood pressure trait male 56 days-59 days 5 146.0 mmHg intra-aortic abdominal radiotelemetry 86400.0 0 67888 830
SS.LEW-(D18Chm90-D18Chm4)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 170.0 mmHg 8.0 17.89 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84481 1438
SS mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 21 177.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70468 1438
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (1 %) (between 42 and 49 days) then controlled sodium content diet (8 %) (for 21 days) Prisco SZ, et al., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550. arterial blood pressure trait male 92 days-98 days 25 148.0 mmHg 2.0 10.0 intra-aortic abdominal radiotelemetry 0.0 0 96803 1698
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled sodium content diet (0.3 %) Prisco SZ, et al., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22. arterial blood pressure trait male 66 days-73 days 11 serial mean 111.0 mmHg 1.0 3.32 intra-aortic abdominal radiotelemetry 14400.0 0 abdominal aorta 4 hrs for 3 consecutive days 96870 1719
SS.MNS-(D2Rat155-D2Chm419)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 16 149.0 mmHg 4.0 16.0 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70459 1438
SS.LEW-(D17Rat84-D17Chm17)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 151.0 mmHg 7.0 19.8 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70445 1438
SS.LEW-(D1Chm64-D1Rat19)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 6 134.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70461 1438
SS.LEW-(D8Rat58-D8Chm12)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 8 150.0 mmHg 4.0 11.31 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84489 1438
SS.LEW-(D1Uia4-D1Rat320)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 6 138.0 mmHg 5.0 12.25 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84500 1438
SS.LEW-(D1Chm64-D1Rat19)(D10Rat194-D10Chm243)(D10Chm10-D10Rat11)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 118.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 84502 1438
SS.LEW-(D17Chm14-D17Rat181)/Ayd percent change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 15.0 % 0.2 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion % change map 69732 344
LEW/Crlc absolute change in heart rate sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 29.0 beats/min 2.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 69734 344
LEW/Crlc maximum change in heart rate to change in mean arterial blood pressure ratio sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 -2.9 beats/min/mmHg 0.2 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion Maximum slope, bpm/mm Hg 69742 344
LEW/Crlc change in heart rate to change in mean arterial blood pressure ratio sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 -2.5 beats/min/mmHg 0.2 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion average slope, bpm/mm Hg 69746 344
SS.LEW-(D17Chm14-D17Rat181)/Ayd change in heart rate to change in mean arterial blood pressure ratio sodium ion solution (800 mmol/l) (for 4 days) then phenylephrine (5-50 ug/min) then sodium nitroprusside (10-100 ug/min) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 -1.7 beats/min/mmHg 0.2 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion average slope, bpm/mm Hg 69748 344
SS-Mthfrem1Mcwi-/+ systolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 152.0 mmHg 6.0 intra-aortic abdominal radiotelemetry 32400.0 0 98415 2059
LEW.SS-(D7Rat27-D7Mgh1)(D17Rat15-D17Rat51)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 41 days) Crespo K, et al., Circ Cardiovasc Genet. 2015 Aug;8(4):610-7. doi: 10.1161/CIRCGENETICS.114.000965. Epub 2015 May 11. arterial blood pressure trait male 67 days-77 days 5 94.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 864000.0 0 97144 1878
LEW.SS-(D8Chm12-D8Rat15)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 41 days) Crespo K, et al., Circ Cardiovasc Genet. 2015 Aug;8(4):610-7. doi: 10.1161/CIRCGENETICS.114.000965. Epub 2015 May 11. arterial blood pressure trait male 67 days-77 days 5 96.0 mmHg 3.0 6.71 intra-aortic abdominal radiotelemetry abdominal aorta 864000.0 0 97147 1878
SS-Mthfrem1Mcwi-/+ mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 130.0 mmHg 4.0 intra-aortic abdominal radiotelemetry 32400.0 0 98401 2059
SS-Nppbem2Mcwi-/- diastolic blood pressure controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. arterial blood pressure trait male 58 days-67 days 0 serial mean 111.0 mmHg 3.0 intra-aortic abdominal radiotelemetry 32400.0 0 98405 2059
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 117.4 mmHg 3.9 6.75 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65692 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 127.9 mmHg 4.0 6.93 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65693 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 134.1 mmHg 4.2 7.27 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65696 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 112.0 mmHg 5.6 9.7 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65702 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 97.8 mmHg 6.8 11.78 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65704 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 146.1 mmHg 2.2 3.81 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65710 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 120.6 mmHg 8.5 14.72 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65712 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 124.3 mmHg 1.6 2.77 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65719 613
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 121.7 mmHg 3.1 5.37 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65656 613
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 171.2 mmHg 5.3 9.18 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65658 613
SS/Jr heart rate controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. heart pumping trait male 73 days-80 days 8 390.0 beats/min 4.1 11.6 intra-aortic abdominal radiotelemetry 10 0 diurnal difference 65503 611
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 172.0 mmHg 5.0 14.14 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65496 611
SS/Jr systolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 199.0 mmHg 5.0 14.14 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65493 611
SS.LEW-(D1Rat211-D1Rat18)/Mco mean arterial blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 146.0 mmHg 3.1 8.77 intra-aortic abdominal radiotelemetry 10 0 average of 24 hr 65501 611
SS.LEW-(D1Rat211-D1Rat18)/Mco absolute change in systolic blood pressure controlled sodium content diet (2 %) (between 34 and 38 days) then controlled exposure to darkness then controlled exposure to ambient light Joe B, et al., J Hypertens 2003 Nov;21(11):2077-84. arterial blood pressure trait male 73 days-80 days 8 14.4 mmHg 1.63 4.61 intra-aortic abdominal radiotelemetry 10 0 diurnal difference 65502 611
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 134.4 mmHg 4.4 7.62 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65627 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 151.3 mmHg 3.5 6.06 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65628 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 138.1 mmHg 4.8 8.31 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65629 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 98.3 mmHg 4.2 7.27 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65633 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 107.5 mmHg 4.0 6.93 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65636 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 99.5 mmHg 1.0 1.73 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65643 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 94.1 mmHg 3.8 6.58 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65648 613
SHRSP/Gcrc systolic blood pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 124 days-128 days 7 continuous mean 250.5 mmHg 4.12 10.9 intra-aortic abdominal radiotelemetry abdominal aorta 0 11620 109
SHRSP/Gcrc systolic blood pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 124 days-128 days 6 continuous mean 197.9 mmHg 4.04 9.9 intra-aortic abdominal radiotelemetry abdominal aorta 0 11621 109
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 214.3 mmHg 5.88 14.4 intra-aortic abdominal radiotelemetry abdominal aorta 0 11632 109
SS.SR-(D13Mit9-D13Mit1)/Jr systolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 122.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11707 119
SS.LEW-(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 8 serial mean 128.0 mmHg 6.0 16.97 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12746 304
SS.SHR-(D9Mco72-D9Mco93)/Mco systolic blood pressure controlled sodium content diet (2 %) (between 35 and 37 days) Toland EJ, et al., J Hypertens. 2008 Nov;26(11):2134-41. arterial blood pressure trait male 75 days-79 days 5 serial mean 146.0 mmHg 1.44 3.22 intra-aortic abdominal radiotelemetry lower abdominal aorta 172800 0 C-40 transmitter (Data Sciences International, St. Paul, MN) average of 12 4-hour averages over 48 hours using 5 or 6 rats 13030 305
SS/Jr mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 36 days) Moujahidine M, et al., Mamm Genome 2002 Mar;13(3):153-6. arterial blood pressure trait male 56 days-71 days 11 serial mean 184.0 mmHg 5.0 16.58 intra-aortic abdominal radiotelemetry aorta 0 0 average of 6 measurements taken every 4 hrs 13078 328
SS.MNS-(D2Rat183-D2Chm113)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 8 145.0 mmHg 4.0 11.31 intra-aortic abdominal radiotelemetry 0 12355 242
SS.MNS-(D2Chm51-D2Rat341)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 21 and 37 days) Dutil J, et al., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28. arterial blood pressure trait male 56 days-72 days 8 144.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 0 12356 242
SR/Jr systolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 138.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11696 119
SHRSP/Gcrc pulse pressure control condition Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 124 days-128 days 7 continuous mean 69.6 mmHg 1.06 2.8 intra-aortic abdominal radiotelemetry abdominal aorta 0 11628 109
SS.LEW-(D17Chm14-D17Rat181)/Ayd mean arterial blood pressure controlled sodium content diet (2 %) (between 43 and 47 days) Grondin M, et al., Physiol Genomics 2005 Mar 21;21(1):112-6. Epub 2005 Jan 4. arterial blood pressure trait male 88 days-92 days 9 142.0 mmHg 4.0 12.0 intra-aortic abdominal radiotelemetry 0 measure every 2 min for 24 hrs 12468 261
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 95.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11698 119
SS.LEW-(D10Chm246-D10Chm257)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 31 and 50 days) Chauvet C, et al., J Hypertens. 2008 May;26(5):893-901. arterial blood pressure trait male 66 days-78 days 10 serial mean 151.0 mmHg 6.0 18.97 intra-aortic abdominal radiotelemetry abdominal aorta 1036800 0 telemetry probe model PA-D70, Data Sciences, St. Paul, MN average of 24 hour averages over 12 days 12745 304
SS/Jr mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 21 days) Charron S, et al., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8. arterial blood pressure trait male 56 days 10 175.0 mmHg 4.0 12.65 intra-aortic abdominal radiotelemetry aorta 0 12544 269
SHRSP/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 178.4 mmHg 2.1 3.64 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65579 613
SHRSP/Gcrc mean arterial blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 129.6 mmHg 2.5 4.33 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65588 613
WKY/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 123.8 mmHg 3.4 5.89 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65600 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 146.4 mmHg 3.7 6.41 intra-aortic abdominal radiotelemetry 3024000 0 Nights (7 PM to 7 AM) 65605 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 91 days-126 days 3 continuous mean 100.2 mmHg 2.4 4.16 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65608 613
SHRSP/Gcrc diastolic blood pressure control condition Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 91 days-126 days 3 continuous mean 124.0 mmHg 2.5 4.33 intra-aortic abdominal radiotelemetry 3024000 0 Days (7 AM to 7 PM) 65534 613
SS.LEW-(D8Rat56-D8Rat51)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 9 197.0 mmHg 5.0 15.0 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70440 1438
SS.LEW-(D17Chm131-D17Chm93)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 5 137.0 mmHg 2.0 4.47 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70444 1438
SS.MNS-(D2Got93-D2Rat222)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 10 163.0 mmHg intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70476 1438
SS.LEW-(D10Chm246-D10Chm257)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 9 133.0 mmHg 5.0 15.0 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70437 1438
SS.LEW-(D10Rat194-D10Chm243)/Ayd mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 11 144.0 mmHg 2.0 6.63 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70450 1438
SS mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 15 177.0 mmHg 4.0 15.49 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70463 1438
SS mean arterial blood pressure controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (between 10 and 24 days) Chauvet C, et al., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28. arterial blood pressure trait male 66 days-80 days 16 184.0 mmHg 4.0 16.0 intra-aortic abdominal radiotelemetry abdominal aorta 0.0 0 70464 1438
SS.LEW-(D17Chm14-D17Rat181)/Ayd absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 4 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 43 days-51 days 0 15.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 68137 344
SS.LEW-(D17Chm14-D17Rat181)/Ayd absolute change in mean arterial blood pressure sodium ion solution (800 mmol/l) (for 14 days) Huang BS, et al., Hypertension. 2007 Apr 9;. arterial blood pressure trait male 53 days-61 days 0 13.0 mmHg 1.0 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion 1min measurement per 30min, 24 hr average 68141 344
SS.SR-(rs65785750-rs13452155)/Opaz mean arterial blood pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 10 157.7 mmHg 3.7 11.7 intra-aortic abdominal radiotelemetry 0.0 0 70358 1358
SS.SR-(rs65785750-rs13452155)/Opaz pulse pressure controlled sodium content diet (8 %) (between 24 and 28 days) Herrera VL, et al., PLoS One. 2012;7(7):e42214. doi: 10.1371/journal.pone.0042214. Epub 2012 Jul 30. arterial blood pressure trait female 108 days-112 days 10 54.11 mmHg 0.4 1.26 intra-aortic abdominal radiotelemetry 0.0 0 70361 1358
SS.LEW-(D10Chm10-D10Rat11)/Ayd percent change in heart rate sodium ion solution (800 mmol/l) (for 4 days) then air-jet exposure (2 lb/in2) (for 0 hours) Huang BS, et al., Hypertension. 2007 Apr 9;. heart pumping trait male 53 days-61 days 0 7.0 % 0.4 intra-aortic abdominal radiotelemetry 0.0 0 blood pressure measured after infusion