SD-Abcb1aem1Sage-/- |
brain uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
brain molecular composition trait |
male |
42 days-56 days |
3 |
75.0 |
% |
5.8 |
10.05 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
|
106165 |
3028 |
SD-Abcb1aem1Sage-/- |
rapidly equilibrated distribution volume of verapamil in retina |
tritiated verapamil (10 uCi) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina molecular composition trait |
male |
42 days-56 days |
3 |
6.25 |
ml/g |
0.76 |
1.32 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
|
|
106111 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina molecular composition trait |
male |
42 days-56 days |
3 |
536.0 |
% |
6.0 |
10.39 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
|
106129 |
3028 |
SD-Abcb1aem1Sage-/- |
brain uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
brain molecular composition trait |
male |
42 days-56 days |
3 |
75.5 |
% |
6.3 |
10.91 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
|
106167 |
3028 |
SD-Abcb1aem1Sage-/- |
verapamil apparent influx permeability clearance in retina |
tritiated verapamil (10 uCi) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina molecular composition trait |
male |
42 days-56 days |
3 |
0.85 |
ml/min/g |
0.57 |
0.98 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
|
|
106105 |
3028 |
SD-Abcb1aem1Sage-/- |
rapidly equilibrated distribution volume of verapamil in aqueous humor |
tritiated verapamil (10 uCi) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
REQUEST NEW TERM (00:0000000) |
male |
42 days-56 days |
3 |
0.13 |
ml/g |
0.0 |
0.0 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
|
aqueous humor molecular composition trait |
106112 |
3028 |
SD-Abcb1aem1Sage-/- |
brain uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
brain molecular composition trait |
male |
42 days-56 days |
3 |
74.0 |
% |
8.3 |
14.38 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
|
106166 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina molecular composition trait |
male |
42 days-56 days |
3 |
379.0 |
% |
18.0 |
31.18 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
|
106131 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
REQUEST NEW TERM (00:0000000) |
male |
42 days-56 days |
3 |
21.0 |
% |
2.4 |
4.16 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
aqueous humor molecular composition trait |
106149 |
3028 |
SD-Abcb1aem1Sage-/- |
verapamil apparent influx permeability clearance in aqueous humor |
tritiated verapamil (10 uCi) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
REQUEST NEW TERM (00:0000000) |
male |
42 days-56 days |
3 |
0.01 |
ml/min/g |
0.0 |
0.0 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
ml/(min x g) |
aqueous humor molecular composition trait |
106106 |
3028 |
SD-Abcb1aem1Sage-/- |
rapidly equilibrated distribution volume of verapamil in brain |
tritiated verapamil (10 uCi) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
brain molecular composition trait |
male |
42 days-56 days |
3 |
3.75 |
ml/g |
0.08 |
0.13 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
|
|
106113 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and vinblastine (1 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina molecular composition trait |
male |
42 days-56 days |
3 |
362.0 |
% |
53.0 |
91.8 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
|
106130 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
REQUEST NEW TERM (00:0000000) |
male |
42 days-56 days |
3 |
24.8 |
% |
1.4 |
2.42 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
aqueous humor molecular composition trait |
106147 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of verapamil |
tritiated verapamil (10 uCi) (for 0 hours) and verapamil (1 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
REQUEST NEW TERM (00:0000000) |
male |
35 days-49 days |
3 |
13.4 |
% |
0.5 |
0.87 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
verapamil uptake index |
aqueous humor molecular composition trait |
106148 |
3028 |