LH/Mav |
heart left ventricle weight to body weight ratio |
perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
heart left ventricle mass |
male |
119 days
| 8 |
|
2.37 |
mg/g |
0.07 |
0.2 |
post excision weight measurement |
|
0.0 |
0 |
103411 |
2824 |
LH/Mav |
aorta weight to body weight ratio |
perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
aorta mass |
male |
119 days
| 8 |
|
12.5 |
mg/100g |
0.6 |
1.7 |
post excision weight measurement |
|
0.0 |
0 |
103415 |
2824 |
LH/Mav |
body weight |
perindopril (0.4 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
161 days
| 8 |
|
459.0 |
g |
10.0 |
28.28 |
body weighing method |
|
0.0 |
0 |
102804 |
2723 |
LH/Mav |
body weight |
perindopril (0.04 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
161 days
| 6 |
|
457.0 |
g |
11.0 |
26.94 |
body weighing method |
|
0.0 |
0 |
102807 |
2723 |
LH/Mav |
plasma total cholesterol level |
streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
blood cholesterol amount |
male |
112 days
| 11 |
|
73.36 |
mg/dl |
4.63 |
15.37 |
blood cholesterol analysis |
|
0.0 |
0 |
102666 |
2703 |
LH/Mav |
body weight |
perindopril (0.1 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
112 days
| 8 |
|
404.0 |
g |
6.0 |
16.97 |
body weighing method |
|
0.0 |
0 |
102789 |
2723 |
LH/Mav |
renal vascular resistance to kidney weight ratio |
perindopril (1.5 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) |
Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. |
kidney blood vessel physiology trait |
male |
84 days
| 7 |
SBP/RBF |
23.0 |
ml/min/g/mmHg |
2.0 |
5.29 |
ultrasonic flowmeter |
|
0.0 |
0 |
102858 |
2761 |
LH/Mav |
renal blood flow rate to kidney weight ratio |
perindopril (1.5 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) |
Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. |
renal blood flow trait |
male |
84 days
| 7 |
|
5.3 |
ml/min/g |
0.5 |
1.32 |
ultrasonic flowmeter |
|
0.0 |
0 |
102854 |
2761 |
LH/Mav |
heart left ventricle weight to body weight ratio |
perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
heart left ventricle mass |
male |
119 days
| 8 |
|
2.41 |
mg/g |
0.08 |
0.23 |
post excision weight measurement |
|
0.0 |
0 |
103410 |
2824 |
LH/Mav |
plasma creatinine level |
streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
blood creatinine amount |
male |
112 days
| 9 |
|
0.54 |
mg/dl |
0.01 |
0.03 |
plasma creatinine analysis |
|
0.0 |
0 |
102677 |
2703 |
SHR/N-cp |
serum glucose level |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 112 and 126 days) then perindopril (0.25-0.5 mg/kg/d) (between 56 and 70 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
blood glucose amount |
male |
140 days-168 days |
8 |
|
179.69 |
mg/dl |
21.78 |
61.6 |
serum glucose analysis |
|
0.0 |
0 |
101506 |
2601 |
SHR/N-cp |
serum glucose level |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
blood glucose amount |
male |
168 days-196 days |
8 |
|
139.76 |
mg/dl |
18.15 |
51.34 |
serum glucose analysis |
|
0.0 |
0 |
101509 |
2601 |
SHR/N-cp |
both kidneys wet weight to body weight ratio |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
kidney mass |
male |
168 days-196 days |
8 |
|
1.67 |
g/kg |
0.1 |
0.28 |
post excision weight measurement |
|
0.0 |
0 |
101524 |
2601 |
LH/Mav |
both kidneys wet weight to body weight ratio |
streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
kidney mass |
male |
112 days
| 9 |
|
7.02 |
g/kg |
0.18 |
0.54 |
post excision weight measurement |
|
0.0 |
0 |
102695 |
2703 |
LH/Mav |
both kidneys wet weight to body weight ratio |
streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
kidney mass |
male |
112 days
| 11 |
|
6.44 |
g/kg |
0.14 |
0.46 |
post excision weight measurement |
|
0.0 |
0 |
102696 |
2703 |
LH/Mav |
body weight |
perindopril (0.04 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
112 days
| 8 |
|
394.0 |
g |
4.0 |
11.31 |
body weighing method |
|
0.0 |
0 |
102788 |
2723 |
LH/Mav |
systolic blood pressure |
perindopril (1.5 mg/kg/d) (for 42 days) |
Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. |
arterial blood pressure trait |
male |
63 days
| 7 |
undefined |
113.0 |
mmHg |
3.0 |
7.94 |
tail cuff plethysmography |
|
0.0 |
0 |
102850 |
2761 |
LH/Mav |
both kidneys wet weight to body weight ratio |
perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
kidney mass |
male |
119 days
| 8 |
|
5.87 |
g/kg |
0.1 |
0.28 |
post excision weight measurement |
|
0.0 |
0 |
103421 |
2824 |
LH/Mav |
body weight |
perindopril (0.1 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
161 days
| 8 |
|
452.0 |
g |
5.0 |
14.14 |
body weighing method |
|
0.0 |
0 |
102803 |
2723 |
LH/Mav |
body weight |
perindopril (0.04 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
161 days
| 8 |
|
442.0 |
g |
6.0 |
16.97 |
body weighing method |
|
0.0 |
0 |
102802 |
2723 |
LH/Mav |
body weight |
perindopril (0.01 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
161 days
| 6 |
|
460.0 |
g |
14.0 |
34.29 |
body weighing method |
|
0.0 |
0 |
102806 |
2723 |
LH/Mav |
plasma triglyceride level |
streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
blood triglyceride amount |
male |
112 days
| 10 |
|
2.42 |
mmol/l |
0.3 |
0.95 |
plasma triglyceride analysis |
|
0.0 |
0 |
102671 |
2703 |
SHR/N-cp |
serum glucose level |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 84 and 98 days) then perindopril (0.25-0.5 mg/kg/d) (between 28 and 42 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
blood glucose amount |
male |
112 days-140 days |
8 |
|
192.39 |
mg/dl |
29.04 |
82.14 |
serum glucose analysis |
|
0.0 |
0 |
101503 |
2601 |
SHR/N-cp |
kidney sclerotic glomeruli count to total glomeruli count ratio |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
kidney glomerulus integrity trait |
male |
168 days-196 days |
8 |
|
9.0 |
% |
4.0 |
11.31 |
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
101527 |
2601 |
Crl:SD |
systolic blood pressure |
controlled protein content diet (20 %) then perindopril (1 mg/kg/d) (for 120 days) |
Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. |
arterial blood pressure trait |
male |
540 days-660 days |
8 |
|
130.0 |
mmHg |
7.0 |
19.8 |
tail cuff plethysmography |
tail |
0.0 |
0 |
108594 |
3126 |
LH/Mav |
body weight |
perindopril (0.4 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
112 days
| 8 |
|
405.0 |
g |
7.0 |
19.8 |
body weighing method |
|
0.0 |
0 |
102790 |
2723 |
LH/Mav |
body weight |
perindopril (0.01 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
112 days
| 6 |
|
391.0 |
g |
8.0 |
19.6 |
body weighing method |
|
0.0 |
0 |
102792 |
2723 |
LH/Mav |
aorta weight to body weight ratio |
perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
aorta mass |
male |
119 days
| 8 |
|
13.6 |
mg/100g |
0.5 |
1.41 |
post excision weight measurement |
|
0.0 |
0 |
103416 |
2824 |
LH/Mav |
plasma triglyceride level |
streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
blood triglyceride amount |
male |
112 days
| 11 |
|
1.5 |
mmol/l |
0.12 |
0.4 |
plasma triglyceride analysis |
|
0.0 |
0 |
102672 |
2703 |
LH/Mav |
plasma creatinine level |
streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
blood creatinine amount |
male |
112 days
| 11 |
|
0.54 |
mg/dl |
0.01 |
0.03 |
plasma creatinine analysis |
|
0.0 |
0 |
102678 |
2703 |
LH/Mav |
heart left ventricle weight to body weight ratio |
streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
heart left ventricle mass |
male |
112 days
| 9 |
|
23.8 |
mg/g |
0.8 |
2.4 |
post excision weight measurement |
|
0.0 |
0 |
102683 |
2703 |
LH/Mav |
aorta weight to body weight ratio |
streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
aorta mass |
male |
112 days
| 9 |
|
12.3 |
mg/100g |
0.4 |
1.2 |
post excision weight measurement |
|
0.0 |
0 |
102689 |
2703 |
LH/Mav |
body weight |
perindopril (0.04 mg/kg/d) (for 98 days) |
Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. |
body mass |
male |
112 days
| 6 |
|
372.0 |
g |
9.0 |
22.05 |
body weighing method |
|
0.0 |
0 |
102793 |
2723 |
SHR/N-cp |
serum glucose level |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 42 and 56 days) then perindopril (0.25-0.5 mg/kg/d) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
blood glucose amount |
male |
70 days-98 days |
8 |
|
154.28 |
mg/dl |
19.97 |
56.47 |
serum glucose analysis |
|
0.0 |
0 |
101500 |
2601 |
SHR/N-cp |
plasma renin activity level |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
renin activity |
male |
168 days-196 days |
8 |
|
52.0 |
ng/ml/h |
8.0 |
22.63 |
radioimmunoassay |
|
0.0 |
0 |
101533 |
2601 |
Crl:SD |
urine total protein excretion rate |
controlled protein content diet (20 %) then perindopril (1 mg/kg/d) (for 120 days) |
Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6. |
total urine protein amount |
male |
540 days-660 days |
8 |
|
32.0 |
mg/d |
9.0 |
25.46 |
Bradford protein assay |
|
0.0 |
0 |
108597 |
3126 |
LH/Mav |
both kidneys wet weight to body weight ratio |
perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
kidney mass |
male |
119 days
| 8 |
|
6.22 |
g/kg |
0.21 |
0.59 |
post excision weight measurement |
|
0.0 |
0 |
103420 |
2824 |
LH/Mav |
plasma total cholesterol level |
streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
blood cholesterol amount |
male |
112 days
| 10 |
|
83.78 |
mg/dl |
6.56 |
20.76 |
blood cholesterol analysis |
|
0.0 |
0 |
102665 |
2703 |
LH/Mav |
heart left ventricle weight to body weight ratio |
streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
heart left ventricle mass |
male |
112 days
| 11 |
|
19.9 |
mg/g |
0.5 |
1.66 |
post excision weight measurement |
|
0.0 |
0 |
102684 |
2703 |
LH/Mav |
aorta weight to body weight ratio |
streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
aorta mass |
male |
112 days
| 11 |
|
10.1 |
mg/100g |
0.2 |
0.66 |
post excision weight measurement |
|
0.0 |
0 |
102690 |
2703 |