Phenominer Database Results (60 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Clinical Measurement Notes Record ID Study ID
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 7 12.5 mg/100g 0.5 1.32 post excision weight measurement 0.0 0 102691 2703
MW glomerular transcapillary hydraulic pressure gradient nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood molecular composition trait male 0 days 8 49.0 mmHg 1.0 2.83 servo-null micropipette transducer method 0.0 5/6 nephrectomy 28 days 101018 2561
MW efferent arteriolar plasma protein concentration nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood total protein amount male 0 days 8 8.0 g/dl 0.2 0.57 micropuncture fluid collection 0.0 5/6 nephrectomy 28 days 101024 2561
MW afferent arteriolar resistance nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. kidney blood vessel physiology trait male 0 days 8 1.0 x 10E10 dyne x s/cm5 0.1 0.28 servo-null micropipette transducer method 0.0 5/6 nephrectomy 28 days 101033 2561
MW urine sodium excretion rate nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. urine sodium amount male 0 days 7 1.78 mEq/d 0.28 0.74 flame photometry 0.0 5/6 nephrectomy 28 days 101050 2561
LH/Mav renal vascular resistance to kidney weight ratio hydralazine (75 mg/kg/d) (for 63 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. kidney blood vessel physiology trait male 84 days 10 SBP/RBF 27.0 ml/min/g/mmHg 2.0 6.32 ultrasonic flowmeter 0.0 0 102869 2761
MW systolic blood pressure right nephrectomy (for 84 days) then reserpine (5 mg/l) (for 28 days) and hydralazine (80 mg/l) (for 28 days) and controlled hydralazine content drinking water (25 mg/l) (for 28 days) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. arterial blood pressure trait male 0 days 10 undefined 131.1 mmHg 4.0 12.65 tail cuff plethysmography 0.0 ~5/6 to 7/8 nephrectomy 84 days 100870 2523
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 7 0.59 mg/dl 0.02 0.04 plasma creatinine analysis 0.0 0 102679 2703
LH/Mav renal blood flow rate to kidney weight ratio hydralazine (75 mg/kg/d) (for 63 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. renal blood flow trait male 84 days 10 4.7 ml/min/g 0.3 0.95 ultrasonic flowmeter 0.0 0 102856 2761
SS/NEisSlc ratio of change in renal sympathetic nerve activity controlled sodium content diet (8 %) (for 28 days) and hydralazine (4 mg/ml) (for 28 days) then tempol (4 mol/l) (between 0 and 0 hours) Fujita M, et al., Hypertension. 2007 Aug;50(2):360-7. Epub 2007 Jun 18. kidney sympathetic nerve activity male 63 days-70 days 7 -17.8 % 1.4 3.7 implanted wire electrode recording method 0.0 0 102388 2687
MW afferent arteriolar plasma flow rate nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. kidney plasma flow trait male 0 days 8 224.0 nl/min 18.0 50.91 servo-null micropipette transducer method 0.0 5/6 nephrectomy 28 days 101006 2561
MW body weight right nephrectomy (for 112 days) then reserpine (5 mg/l) (for 56 days) and hydralazine (80 mg/l) (for 56 days) and controlled hydralazine content drinking water (25 mg/l) (for 56 days) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. body mass male 0 days 10 244.3 g 17.2 54.39 body weighing method 0.0 ~5/6 to 7/8 nephrectomy 112 days 100828 2523
MW blood urea nitrogen level right nephrectomy (for 112 days) then reserpine (5 mg/l) (for 56 days) and hydralazine (80 mg/l) (for 56 days) and controlled hydralazine content drinking water (25 mg/l) (for 56 days) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. blood urea nitrogen amount male 0 days 10 73.6 mg/dl 4.3 13.6 blood urea nitrogen analysis 0.0 ~5/6 to 7/8 nephrectomy 112 days 100842 2523
MW hematocrit right nephrectomy (for 56 days) then reserpine (5 mg/l) and hydralazine (80 mg/l) and controlled hydralazine content drinking water (25 mg/l) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. erythrocyte quantity male 0 days 10 48.4 % 1.4 4.43 hematocrit analysis 0.0 ~5/6 to 7/8 nephrectomy 56 days 100849 2523
MW systolic blood pressure right nephrectomy (for 56 days) then reserpine (5 mg/l) and hydralazine (80 mg/l) and controlled hydralazine content drinking water (25 mg/l) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. arterial blood pressure trait male 0 days 10 undefined 180.6 mmHg 7.7 24.35 tail cuff plethysmography 0.0 ~5/6 to 7/8 nephrectomy 56 days 100863 2523
SHR/N-cp plasma renin activity level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. renin activity male 140 days-168 days 8 38.0 ng/ml/h 2.0 5.66 radioimmunoassay 0.0 0 101534 2601
MW body weight right nephrectomy (for 56 days) then reserpine (5 mg/l) and hydralazine (80 mg/l) and controlled hydralazine content drinking water (25 mg/l) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. body mass male 0 days 10 276.6 g 7.4 23.4 body weighing method 0.0 ~5/6 to 7/8 nephrectomy 56 days 100800 2523
SS/NEisSlc percent change in heart rate controlled sodium content diet (8 %) (for 28 days) and hydralazine (4 mg/ml) (for 28 days) then tempol (4 mol/l) (between 0 and 0 hours) Fujita M, et al., Hypertension. 2007 Aug;50(2):360-7. Epub 2007 Jun 18. heart pumping trait male 63 days-70 days 7 -10.5 % 1.9 5.03 vascular fluid filled catheter 0.0 0 102387 2687
SS/NEisSlc percent change in mean arterial blood pressure controlled sodium content diet (8 %) (for 28 days) and hydralazine (4 mg/ml) (for 28 days) then tempol (4 mol/l) (between 0 and 0 hours) Fujita M, et al., Hypertension. 2007 Aug;50(2):360-7. Epub 2007 Jun 18. arterial blood pressure trait male 63 days-70 days 7 -22.1 % 2.5 6.61 vascular fluid filled catheter 0.0 0 102386 2687
LH/Mav heart left ventricle weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 6 2.88 mg/g 0.06 0.15 post excision weight measurement 0.0 0 103412 2824
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 7 8.05 g/kg 0.24 0.63 post excision weight measurement 0.0 0 102697 2703
MW mean proximal tubular hydraulic pressure nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood molecular composition trait male 0 days 8 16.0 mmHg 1.0 2.83 servo-null micropipette transducer method 0.0 5/6 nephrectomy 28 days 101012 2561
MW efferent arteriolar hydraulic pressure nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood molecular composition trait male 0 days 8 21.0 mmHg 1.0 2.83 servo-null micropipette transducer method 0.0 5/6 nephrectomy 28 days 101015 2561
MW body weight nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. body mass male 0 days 8 233.0 g 4.0 11.31 body weighing method 0.0 5/6 nephrectomy 28 days 100985 2561
MW hematocrit nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. erythrocyte quantity male 0 days 8 36.0 % 1.0 2.83 hematocrit analysis 0.0 5/6 nephrectomy 28 days 100988 2561
MW hematocrit right nephrectomy (for 112 days) then reserpine (5 mg/l) (for 56 days) and hydralazine (80 mg/l) (for 56 days) and controlled hydralazine content drinking water (25 mg/l) (for 56 days) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. erythrocyte quantity male 0 days 10 45.8 % 0.7 2.21 hematocrit analysis 0.0 ~5/6 to 7/8 nephrectomy 112 days 100856 2523
MW efferent colloid osmotic pressure nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood molecular composition trait male 0 days 8 32.0 mmHg 2.0 5.66 micropuncture fluid collection 0.0 5/6 nephrectomy 28 days efferent arteriolar colloid osmotic pressure 101030 2561
SHR/N-cp both kidneys wet weight to body weight ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney mass male 140 days-168 days 8 1.83 g/kg 0.31 0.88 post excision weight measurement 0.0 0 101525 2601
SHR/N-cp kidney sclerotic glomeruli count to total glomeruli count ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney glomerulus integrity trait male 140 days-168 days 8 4.0 % 1.0 2.83 ex vivo light microscopy with histochemistry 0.0 0 101528 2601
MW plasma renin activity level nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. renin activity male 0 days 7 21.9 ng/ml/h 2.5 6.61 radioimmunoassay 0.0 5/6 nephrectomy 28 days 101046 2561
MW body weight right nephrectomy (for 84 days) then reserpine (5 mg/l) (for 28 days) and hydralazine (80 mg/l) (for 28 days) and controlled hydralazine content drinking water (25 mg/l) (for 28 days) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. body mass male 0 days 10 276.6 g 7.4 23.4 body weighing method 0.0 ~5/6 to 7/8 nephrectomy 84 days 100807 2523
SS/NEisSlc mean arterial blood pressure controlled sodium content diet (8 %) (for 28 days) and hydralazine (4 mg/ml) (for 28 days) Fujita M, et al., Hypertension. 2007 Aug;50(2):360-7. Epub 2007 Jun 18. arterial blood pressure trait male 63 days-70 days 7 110.0 mmHg 5.0 13.23 vascular fluid filled catheter 0.0 0 102384 2687
SS/NEisSlc heart rate controlled sodium content diet (8 %) (for 28 days) and hydralazine (4 mg/ml) (for 28 days) Fujita M, et al., Hypertension. 2007 Aug;50(2):360-7. Epub 2007 Jun 18. heart pumping trait male 63 days-70 days 7 398.0 beats/min 13.0 34.39 vascular fluid filled catheter 0.0 0 102385 2687
LH/Mav aorta weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 7 15.8 mg/100g 0.8 2.12 post excision weight measurement 0.0 0 103418 2824
LH/Mav both kidneys wet weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 6 7.22 g/kg 0.34 0.83 post excision weight measurement 0.0 0 103422 2824
LH/Mav both kidneys wet weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 7 7.3 g/kg 0.09 0.24 post excision weight measurement 0.0 0 103423 2824
MW glomerular filtration rate right nephrectomy (for 112 days) then reserpine (5 mg/l) (for 56 days) and hydralazine (80 mg/l) (for 56 days) and controlled hydralazine content drinking water (25 mg/l) (for 56 days) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. glomerular filtration trait male 0 days 10 0.32 ml/min 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 ~5/6 to 7/8 nephrectomy 112 days 100884 2523
MW systolic blood pressure right nephrectomy (for 112 days) then reserpine (5 mg/l) (for 56 days) and hydralazine (80 mg/l) (for 56 days) and controlled hydralazine content drinking water (25 mg/l) (for 56 days) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. arterial blood pressure trait male 0 days 10 undefined 149.4 mmHg 8.3 26.25 tail cuff plethysmography 0.0 ~5/6 to 7/8 nephrectomy 112 days 100880 2523
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 7 24.2 mg/g 0.3 0.79 post excision weight measurement 0.0 0 102685 2703
MW single nephron glomerular filtration rate nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. glomerular filtration trait male 0 days 8 63.6 nl/min 5.2 14.71 micropuncture fluid collection 0.0 5/6 nephrectomy 28 days 101000 2561
MW glomerular capillary hydraulic pressure nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood molecular composition trait male 0 days 8 65.0 mmHg 1.0 2.83 servo-null micropipette transducer method 0.0 5/6 nephrectomy 28 days 101009 2561
MW single nephron filtration fraction nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. glomerular filtration trait male 0 days 8 0.29 null 0.02 0.06 micropuncture fluid collection 0.0 5/6 nephrectomy 28 days 101003 2561
MW blood urea nitrogen level right nephrectomy (for 56 days) then reserpine (5 mg/l) and hydralazine (80 mg/l) and controlled hydralazine content drinking water (25 mg/l) Kakinuma Y, et al., Kidney Int. 1992 Jul;42(1):46-55. blood urea nitrogen amount male 0 days 10 53.9 mg/dl 5.4 17.08 blood urea nitrogen analysis 0.0 ~5/6 to 7/8 nephrectomy 56 days 100835 2523
MW afferent arteriolar plasma protein concentration nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood total protein amount male 0 days 8 5.7 g/dl 0.1 0.28 micropuncture fluid collection 0.0 5/6 nephrectomy 28 days 101021 2561
MW efferent arteriolar resistance nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. kidney blood vessel physiology trait male 0 days 8 1.28 x 10E10 dyne x s/cm5 0.11 0.31 servo-null micropipette transducer method 0.0 5/6 nephrectomy 28 days 101036 2561
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 140 days-168 days 8 139.76 mg/dl 29.04 82.14 serum glucose analysis 0.0 0 101510 2601
MW glomerular filtration rate nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. glomerular filtration trait male 0 days 8 0.61 ml/min 0.08 0.23 inulin analysis by liquid phase colorimetry 0.0 5/6 nephrectomy 28 days 100994 2561
LH/Mav heart left ventricle weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 7 2.79 mg/g 0.04 0.11 post excision weight measurement 0.0 0 103413 2824
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 7 1.58 mmol/l 0.08 0.21 plasma triglyceride analysis 0.0 0 102673 2703
MW plasma urea nitrogen level nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood urea nitrogen amount male 0 days 8 21.42 mmol/l 1.43 4.04 plasma urea nitrogen analysis 0.0 5/6 nephrectomy 28 days 100991 2561
MW mean arterial blood pressure nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. arterial blood pressure trait male 0 days 8 undefined 107.0 mmHg 3.0 8.49 vascular indwelling catheter method 0.0 5/6 nephrectomy 28 days 100997 2561
LH/Mav aorta weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 6 15.7 mg/100g 0.8 1.96 post excision weight measurement 0.0 0 103417 2824
MW afferent colloid osmotic pressure nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. blood molecular composition trait male 0 days 8 19.0 mmHg 0.4 1.13 micropuncture fluid collection 0.0 5/6 nephrectomy 28 days 101027 2561
MW total arteriolar resistance nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. kidney blood vessel physiology trait male 0 days 8 2.28 x 10E10 dyne x s/cm5 0.18 0.51 servo-null micropipette transducer method 0.0 5/6 nephrectomy 28 days 101039 2561
MW glomerular capillary ultrafiltration coefficient nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. glomerular filtration trait male 0 days 8 0.05 nl/(s x mmHg) 0.0 0.01 micropuncture fluid collection 0.0 5/6 nephrectomy 28 days 101042 2561
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 42 and 56 days) then controlled hydralazine content drinking water (30 mg/l) and hydralazine (50 mg/l) and reserpine (4 mg/l) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 70 days-98 days 8 139.76 mg/dl 14.52 41.07 serum glucose analysis 0.0 0 101501 2601
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 112 and 126 days) then controlled hydralazine content drinking water (30 mg/l) (between 56 and 70 days) and hydralazine (50 mg/l) (between 56 and 70 days) and reserpine (4 mg/l) (between 56 and 70 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 140 days-168 days 8 157.91 mg/dl 34.49 97.54 serum glucose analysis 0.0 0 101507 2601
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 84 and 98 days) then controlled hydralazine content drinking water (30 mg/l) (between 28 and 42 days) and hydralazine (50 mg/l) (between 28 and 42 days) and reserpine (4 mg/l) (between 28 and 42 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 112 days-140 days 8 137.94 mg/dl 30.86 87.27 serum glucose analysis 0.0 0 101504 2601
LH/Mav systolic blood pressure hydralazine (75 mg/kg/d) (for 42 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 42 days) and reserpine (0.75 mg/kg/d) (for 42 days) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. arterial blood pressure trait male 63 days 10 undefined 133.0 mmHg 2.0 6.32 tail cuff plethysmography 0.0 0 102852 2761
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 7 110.81 mg/dl 4.25 11.24 blood cholesterol analysis 0.0 0 102667 2703