Phenominer Database Results (274 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood cholesterol amount male 112 days 14 116.22 mg/dl 4.25 15.89 plasma total cholesterol measurement test 0.0 0 102753 2721
LL/Mav plasma triglyceride level streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood triglyceride amount male 112 days 18 1.46 mmol/l 0.08 0.34 plasma triglyceride analysis 0.0 0 102755 2721
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. aorta mass male 112 days 14 13.1 mg/100g 0.1 0.37 post excision weight measurement 0.0 0 102773 2721
LH/Mav creatinine clearance streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. glomerular filtration trait male 112 days 14 1.4 ml/min 0.05 0.19 plasma creatinine analysis 0.0 0 102777 2721
SD glomerular filtration rate to body weight ratio streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. glomerular filtration trait male 0 days 8 0.67 ml/min/100g 0.02 0.06 inulin analysis by thiourea-resorcinol assay 0.0 stz 154 days 99902 2358
SD glomerular filtration rate to body weight ratio streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. glomerular filtration trait male 0 days 8 0.68 ml/min/100g 0.02 0.06 inulin analysis by thiourea-resorcinol assay 0.0 stz 154 days 99903 2358
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.5 ml/min/100g 0.03 0.12 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99981 2378
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 16 44.5 % 0.6 2.4 hematocrit analysis 0.0 unx 168 days 99979 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 17 3.3 ml/min/100g 0.11 0.45 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99992 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 16 7.1 mmHg/ml/min 0.3 1.2 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99998 2378
MHS urine sodium excretion rate streptozotocin (50 mg/kg) (for 147 days) then insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. urine sodium amount male 213 days 6 0.81 mEq/d 0.1 0.25 urine sodium analysis 0.0 0 104031 2886
MNS urine sodium excretion rate streptozotocin (50 mg/kg) (for 147 days) then insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. urine sodium amount male 213 days 9 2.07 mEq/d 0.45 1.36 urine sodium analysis 0.0 0 104032 2886
MNS urine potassium excretion rate streptozotocin (50 mg/kg) (for 147 days) then insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. urine potassium amount male 213 days 9 3.52 mEq/d 0.68 2.04 urine potassium analysis 0.0 0 104034 2886
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 10 2.42 mmol/l 0.3 0.95 plasma triglyceride analysis 0.0 0 102671 2703
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 7 8.05 g/kg 0.24 0.63 post excision weight measurement 0.0 0 102697 2703
LH/Mav timed urine volume streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine output male 49 days-56 days 37 12.6 ml/d 0.7 4.26 urine volume measurement method 0.0 0 102649 2703
WKY body weight streptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. body mass male 156 days 10 261.43 g 21.34 67.48 body weighing method 0.0 0 99109 2219
WKY single kidney wet weight to body weight ratio streptozotocin (60 mg/kg) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. kidney mass male 156 days 10 5.47 g/kg 0.46 1.45 post excision weight measurement 0.0 0 99114 2219
WKY single kidney wet weight to body weight ratio streptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. kidney mass male 156 days 10 4.46 g/kg 0.42 1.33 post excision weight measurement 0.0 0 99116 2219
WKY body weight streptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. body mass male 156 days 10 295.56 g 21.89 69.22 body weighing method 0.0 0 99110 2219
WKY single kidney wet weight to body weight ratio streptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. kidney mass male 156 days 10 5.42 g/kg 0.51 1.61 post excision weight measurement 0.0 0 99115 2219
WKY timed urine volume streptozotocin (60 mg/kg) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. urine output male 156 days 10 140.19 ml/d 10.38 32.82 urine volume measurement method 0.0 0 99120 2219
SD left kidney wet weight streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. kidney mass male 0 days 8 1.94 g 0.02 0.07 post excision weight measurement 0.0 stz 154 days 99893 2358
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 364 days 6 2.18 x 10E6 um3 0.11 0.27 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100773 2522
SD body weight streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. body mass male 0 days 8 570.0 g 31.47 89.0 body weighing method 0.0 stz 224 days 99915 2358
SD renal filtration fraction streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. glomerular filtration trait male 0 days 8 0.29 null 0.01 0.02 p-aminohippurate analysis by liquid phase colorimetry 0.0 stz 154 days GFR by inulin method 99912 2358
SD systolic blood pressure streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. arterial blood pressure trait male 0 days 8 undefined 150.0 mmHg 1.41 4.0 tail cuff plethysmography 0.0 stz 224 days 99923 2358
SD renal filtration fraction streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. glomerular filtration trait male 0 days 8 0.29 null 0.0 0.01 p-aminohippurate analysis by liquid phase colorimetry 0.0 stz 224 days GFR by inulin method 99932 2358
SD effective renal plasma flow streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. kidney plasma flow trait male 0 days 8 2.27 ml/min/100g 0.06 0.18 p-aminohippurate analysis by liquid phase colorimetry 0.0 stz 224 days 99930 2358
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 357.0 mg/dl 11.0 31.11 machine read blood glucose test strip 0.0 unx 28 days 99943 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 6 0.5 ml/min/100g 0.02 0.06 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99949 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 8 3.09 ml/min/100g 0.18 0.51 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99951 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 8 2.32 ml/min/100g 0.11 0.31 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99953 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 8 8.8 mmHg/ml/min 0.5 1.41 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99962 2378
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 179.66 null 2.47 6.05 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100791 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) and anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 201.84 null 11.34 27.78 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100792 2522
MNS artery inner diameter streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 12.0 um 5.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104147 2907
MHS artery lumen to artery total diameter ratio streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 36.9 % 9.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104153 2907
MNS body weight streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 84 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. body mass male 168 days 8 370.0 g 13.79 39.0 body weighing method 0.0 0 104065 2907
MHS body weight streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 84 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. body mass male 168 days 9 364.0 g 13.67 41.0 body weighing method 0.0 0 104067 2907
Crl:WI body weight streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. body mass male 252 days 14 354.0 g 10.69 40.0 body weighing method 0.0 0 104073 2907
MNS mean arterial blood pressure streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 84 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. arterial blood pressure trait male 168 days 6 94.8 mmHg 2.08 5.1 vascular fluid filled catheter trunk of common carotid artery 0.0 0 104103 2907
MNS glomerular filtration rate streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. glomerular filtration trait male 126 days 6 4.1 ml/min 0.13 0.33 inulin analysis by liquid phase colorimetry 0.0 0 104115 2907
MHS renal plasma flow (inulin) streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney plasma flow trait male 126 days 6 13.66 ml/min 0.62 1.51 inulin analysis by liquid phase colorimetry 0.0 0 104125 2907
SBH/Ygl systolic blood pressure controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. arterial blood pressure trait male 98 days 7 181.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 0 106699 3038
SBH/Ygl body weight controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. body mass male 98 days 7 223.0 g 15.0 39.69 body weighing method 0.0 0 106702 3038
SBH/Ygl heart weight controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. heart mass male 98 days 7 1.07 g 0.07 0.18 post excision weight measurement 0.0 0 106710 3038
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 11.1 x 10E3 um2 2.8 11.2 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107513 2378
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 17 3.2 g/kg 0.1 0.41 post excision weight measurement 0.0 unx 150 days 107452 2378
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 16 267.0 g 9.0 36.0 body weighing method 0.0 unx 150 days 107449 2378
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 16 8.1 mg/g 0.2 0.8 post excision weight measurement 0.0 unx 150 days 107458 2378
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 11.8 x 10E3 um2 2.9 11.96 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107512 2378
MNS glomerular filtration rate streptozotocin (50 mg/kg) (for 147 days) and insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. glomerular filtration trait male 213 days 9 0.0 ml/min 0.0 0.0 inulin analysis by liquid phase colorimetry 0.0 0 104028 2886
LL/Mav plasma total cholesterol level streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood cholesterol amount male 112 days 18 52.9 mg/dl 1.54 6.55 plasma total cholesterol measurement test 0.0 0 102751 2721
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. kidney mass male 112 days 14 6.65 g/kg 0.08 0.3 post excision weight measurement 0.0 0 102765 2721
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 16 0.22 null 0.01 0.04 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99988 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 17 1.72 ml/min/100g 0.11 0.45 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99991 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 16 6.8 mmHg/ml/min 0.3 1.2 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99999 2378
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 7 110.81 mg/dl 4.25 11.24 blood cholesterol analysis 0.0 0 102667 2703
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 7 0.59 mg/dl 0.02 0.04 plasma creatinine analysis 0.0 0 102679 2703
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 7 1.58 mmol/l 0.08 0.21 plasma triglyceride analysis 0.0 0 102673 2703
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 11 10.1 mg/100g 0.2 0.66 post excision weight measurement 0.0 0 102690 2703
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 9 7.02 g/kg 0.18 0.54 post excision weight measurement 0.0 0 102695 2703
SD left kidney wet weight streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. kidney mass male 0 days 8 1.9 g 0.04 0.1 post excision weight measurement 0.0 stz 154 days 99894 2358
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 8 2.33 ml/min/100g 0.09 0.25 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99952 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.79 ml/min/100g 0.03 0.08 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99946 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.54 ml/min/100g 0.02 0.05 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99948 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.26 null 0.01 0.04 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99956 2378
LL/Mav body weight streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 56 days 18 215.0 g 3.0 12.73 body weighing method 0.0 0 102699 2721
LH/Mav body weight streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 112 days 14 388.0 g 5.0 18.71 body weighing method 0.0 0 102725 2721
LH/Mav systolic blood pressure streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 112 days 14 mean of 3 samples of undefined duration serial mean 179.0 mmHg 4.0 14.97 tail cuff plethysmography 0.0 0 102729 2721
LL/Mav timed urine volume streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 112 days 18 10.8 ml/d 0.3 1.27 urine volume measurement method 0.0 0 102731 2721
LH/Mav urine total protein excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 112 days 14 184.0 mg/d 11.0 41.16 urine protein analysis 0.0 0 102737 2721
LH/Mav urine creatinine excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine creatinine amount male 112 days 14 13.3 mg/d 0.2 0.75 urine creatinine analysis 0.0 0 102749 2721
LL/Mav plasma creatinine level streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood creatinine amount male 112 days 18 0.5 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102759 2721
LL/Mav both kidneys wet weight to body weight ratio streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. kidney mass male 112 days 18 6.61 g/kg 0.08 0.34 post excision weight measurement 0.0 0 102763 2721
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. heart left ventricle mass male 112 days 14 2.25 mg/g 0.0 0.01 post excision weight measurement 0.0 0 102769 2721
WKY timed urine volume streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. urine output male 156 days 10 53.91 ml/d 7.67 24.25 urine volume measurement method 0.0 0 99124 2219
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 16 317.0 mg/dl 19.0 76.0 machine read blood glucose test strip 0.0 unx 168 days 99974 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 17 41.47 ml/d 4.46 18.41 metabolic cage urine volume measurement method 0.0 unx 168 days 100002 2378
MHS timed urine volume streptozotocin (50 mg/kg) (for 147 days) then insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. urine output male 213 days 6 50.83 ml/d 6.48 15.87 urine volume measurement method 3600.0 0 104029 2886
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 9 0.54 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102677 2703
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 8 24.4 mg/g 0.4 1.13 post excision weight measurement 0.0 0 102682 2703
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 7 12.5 mg/100g 0.5 1.32 post excision weight measurement 0.0 0 102691 2703
LL/Mav urine total protein excretion rate streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 56 days 18 32.0 mg/d 2.0 8.49 urine protein analysis 0.0 0 102711 2721
LH/Mav timed urine volume streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 56 days 14 10.6 ml/d 0.3 1.12 urine volume measurement method 0.0 0 102709 2721
WKY blood glucose level streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 534.6 mg/dl 22.5 71.15 radioimmunoassay 0.0 0 99106 2219
WKY body weight streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. body mass male 156 days 10 287.24 g 20.18 63.81 body weighing method 0.0 0 99111 2219
MHS mean arterial blood pressure streptozotocin (50 mg/kg) (for 147 days) then insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. arterial blood pressure trait male 213 days 6 127.2 mmHg 3.5 8.57 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 104023 2886
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 364 days 6 158.59 null 4.58 11.22 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100776 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 364 days 6 182.12 null 13.44 32.92 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100777 2522
SD glomerular filtration rate to body weight ratio streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. glomerular filtration trait male 0 days 8 0.67 ml/min/100g 0.03 0.08 inulin analysis by thiourea-resorcinol assay 0.0 stz 224 days 99926 2358
SD effective renal plasma flow streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. kidney plasma flow trait male 0 days 8 2.31 ml/min/100g 0.08 0.22 p-aminohippurate analysis by liquid phase colorimetry 0.0 stz 224 days 99929 2358
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 8 233.0 g 5.0 14.14 body weighing method 0.0 unx 28 days 99938 2378
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 6 229.0 g 6.0 14.7 body weighing method 0.0 unx 28 days 99939 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 350.0 mg/dl 18.0 50.91 machine read blood glucose test strip 0.0 unx 28 days 99941 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 352.0 mg/dl 17.0 48.08 machine read blood glucose test strip 0.0 unx 28 days 99942 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.23 null 0.12 0.34 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99957 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 6 8.8 mmHg/ml/min 0.5 1.22 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99964 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 8 41.62 ml/d 9.07 25.66 metabolic cage urine volume measurement method 0.0 unx 28 days 99968 2378
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) and anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 2.37 x 10E6 um3 0.15 0.37 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100787 2522
MHS artery tunica media width to artery inner diameter ratio streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 0.93 null 0.46 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104137 2907
MNS blood hemoglobin A1c level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood hemoglobin amount male 252 days 11 15.5 % 0.63 2.1 affinity chromatography tail vein 0.0 0 affinity chromatography (MMO:0000845) 104095 2907
SBH/Ygl heart weight controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. heart mass male 98 days 7 1.03 g 0.08 0.2 post excision weight measurement 0.0 0 106711 3038
SBH/Ygl heart left ventricle end-diastolic diameter to body weight ratio controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. heart left ventricle end-diastolic diameter male 98 days 7 2.6 mm/kg 0.2 0.53 transthoracic echocardiography 0.0 0 106718 3038
SBH/Ygl heart left ventricle end-diastolic diameter to body weight ratio controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. heart left ventricle end-diastolic diameter male 98 days 7 2.7 mm/kg 0.1 0.26 transthoracic echocardiography 0.0 0 106719 3038
SBH/Ygl heart left ventricle end-systolic diameter to body weight ratio controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. heart left ventricle end-systolic diameter male 98 days 7 0.99 mm/kg 0.1 0.26 transthoracic echocardiography 0.0 0 106722 3038
SBH/Ygl blood glucose level controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. blood glucose amount male 98 days 7 361.8 mg/dl 32.4 85.72 blood glucose test strip read by electrochemical glucometer 0.0 0 106695 3038
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 17 9.9 mg/g 0.7 2.89 post excision weight measurement 0.0 unx 150 days 107456 2378
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 16 8.3 mg/g 0.2 0.8 post excision weight measurement 0.0 unx 150 days 107459 2378
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 11.7 x 10E3 um2 2.9 11.6 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107514 2378
MNS timed urine volume streptozotocin (50 mg/kg) (for 147 days) then insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. urine output male 213 days 9 56.88 ml/d 11.23 33.7 urine volume measurement method 3600.0 0 104030 2886
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 9 1.96 mmol/l 0.2 0.6 plasma triglyceride analysis 0.0 0 102670 2703
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 8 0.61 mg/dl 0.05 0.14 plasma creatinine analysis 0.0 0 102676 2703
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 11 19.9 mg/g 0.5 1.66 post excision weight measurement 0.0 0 102684 2703
LH/Mav urine total protein excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 56 days 14 127.0 mg/d 7.0 26.19 urine protein analysis 0.0 0 102713 2721
SD systolic blood pressure streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. arterial blood pressure trait male 0 days 8 undefined 152.0 mmHg 1.06 3.0 tail cuff plethysmography 0.0 stz 154 days 99899 2358
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 8 9.2 mmHg/ml/min 0.4 1.13 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99963 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 8 9.0 mmHg/ml/min 0.4 1.13 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99961 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 6 44.93 ml/d 8.78 21.52 metabolic cage urine volume measurement method 0.0 unx 28 days 99969 2378
MHS glomerular filtration rate streptozotocin (50 mg/kg) (for 147 days) and insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. glomerular filtration trait male 213 days 6 0.0 ml/min 0.0 0.0 inulin analysis by liquid phase colorimetry 0.0 0 104027 2886
LH/Mav body weight streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 56 days 14 248.0 g 4.0 14.97 body weighing method 0.0 0 102701 2721
LH/Mav blood glucose level streptozotocin (75 mg/kg) then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 14 72.0 mg/dl 1.0 3.74 blood glucose analysis 0.0 0 102717 2721
LL/Mav urine albumin excretion rate streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 18 3.6 mg/d 0.2 0.85 urine albumin analysis 0.0 0 102739 2721
LH/Mav urine albumin excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 14 35.6 mg/d 1.8 6.73 urine albumin analysis 0.0 0 102741 2721
LL/Mav heart left ventricle weight to body weight ratio streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. heart left ventricle mass male 112 days 18 1.93 mg/g 0.0 0.01 post excision weight measurement 0.0 0 102767 2721
LL/Mav creatinine clearance streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. glomerular filtration trait male 112 days 18 1.35 ml/min 0.05 0.21 plasma creatinine analysis 0.0 0 102775 2721
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 17 45.6 % 0.3 1.24 hematocrit analysis 0.0 unx 168 days 99977 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 16 0.66 ml/min/100g 0.02 0.09 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99983 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 16 3.19 ml/min/100g 0.13 0.52 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99994 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 17 16.7 mmHg/ml/min 1.4 5.77 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99996 2378
LH/Mav blood glucose level streptozotocin (75 mg/kg) then fasting (for 16 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 37 70.0 mg/dl 1.0 6.08 blood glucose analysis 0.0 0 102658 2703
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 11 1.5 mmol/l 0.12 0.4 plasma triglyceride analysis 0.0 0 102672 2703
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 11 0.54 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102678 2703
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 9 23.8 mg/g 0.8 2.4 post excision weight measurement 0.0 0 102683 2703
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 8 13.5 mg/100g 0.5 1.41 post excision weight measurement 0.0 0 102688 2703
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 8 6.95 g/kg 0.23 0.65 post excision weight measurement 0.0 0 102694 2703
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 9 12.3 mg/100g 0.4 1.2 post excision weight measurement 0.0 0 102689 2703
LH/Mav systolic blood pressure streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 56 days 14 mean of 3 samples of undefined duration serial mean 148.0 mmHg 4.0 14.97 tail cuff plethysmography 0.0 0 102705 2721
LL/Mav timed urine volume streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 56 days 18 8.9 ml/d 0.3 1.27 urine volume measurement method 0.0 0 102707 2721
LH/Mav body weight streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. body mass male 49 days-56 days 37 233.0 g 4.0 24.33 body weighing method 0.0 0 102643 2703
LH/Mav urine creatinine excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine creatinine amount male 49 days-56 days 37 8.6 mg/d 0.3 1.82 urine creatinine analysis 0.0 0 102652 2703
WKY blood glucose level streptozotocin (60 mg/kg) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 520.92 mg/dl 28.8 91.07 radioimmunoassay 0.0 0 99102 2219
WKY timed urine volume streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. urine output male 156 days 10 58.33 ml/d 8.45 26.72 urine volume measurement method 0.0 0 99123 2219
SD body weight streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. body mass male 0 days 8 563.0 g 12.37 35.0 body weighing method 0.0 stz 154 days 99891 2358
SD body weight streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. body mass male 0 days 8 588.0 g 27.58 78.0 body weighing method 0.0 stz 224 days 99914 2358
SD left kidney wet weight streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. kidney mass male 0 days 8 2.18 g 0.05 0.14 post excision weight measurement 0.0 stz 224 days 99917 2358
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 8 215.0 g 10.0 28.28 body weighing method 0.0 unx 28 days 99936 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.52 ml/min/100g 0.03 0.07 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99947 2378
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 2.4 x 10E6 um3 0.11 0.27 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100786 2522
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 3.14 x 10E6 um3 0.19 0.47 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100784 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 158.33 null 4.59 11.24 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100789 2522
MNS artery tunica media width to artery inner diameter ratio streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 0.64 null 0.28 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104135 2907
MNS artery tunica media to artery total diameter ratio streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 26.8 % 5.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104143 2907
MNS body weight streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. body mass male 252 days 12 345.0 g 15.01 52.0 body weighing method 0.0 0 104069 2907
MNS blood glucose level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood glucose amount male 252 days 11 473.4 mg/dl 13.03 43.2 colorimetry tail vein 0.0 0 104082 2907
MHS mean arterial blood pressure streptozotocin (55 ml/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. arterial blood pressure trait male 252 days 6 139.8 mmHg 1.84 4.5 vascular fluid filled catheter trunk of common carotid artery 0.0 0 104109 2907
MNS mean arterial blood pressure streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. arterial blood pressure trait male 252 days 6 94.4 mmHg 0.98 2.4 vascular fluid filled catheter trunk of common carotid artery 0.0 0 104107 2907
MHS mean arterial blood pressure streptozotocin (55 ml/kg) then insulin (4 IU/kg) (for 84 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. arterial blood pressure trait male 168 days 6 138.1 mmHg 4.78 11.7 vascular fluid filled catheter trunk of common carotid artery 0.0 0 104105 2907
MHS glomerular filtration rate streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. glomerular filtration trait male 126 days 6 3.43 ml/min 0.13 0.31 inulin analysis by liquid phase colorimetry 0.0 0 104117 2907
MNS renal plasma flow (inulin) streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney plasma flow trait male 126 days 6 13.39 ml/min 0.53 1.3 inulin analysis by liquid phase colorimetry 0.0 0 104123 2907
MHS renal vascular resistance streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. renal blood flow trait male 126 days 6 6.2 mmHg/ml/min 0.35 0.86 inulin analysis by liquid phase colorimetry 0.0 0 104129 2907
SBH/Ygl body weight controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. body mass male 98 days 7 216.0 g 13.0 34.39 body weighing method 0.0 0 106703 3038
SBH/Ygl food intake weight to body weight ratio controlled sodium chloride content diet (0.65 %) (for 84 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 28 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. eating behavior trait male 84 days 7 18.04 g/d/100g 0.82 2.17 food intake measuring method 0.0 0 106706 3038
SBH/Ygl heart left ventricle fractional shortening controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. heart left ventricle end-diastolic diameter male 98 days 7 61.0 % 4.0 10.58 transthoracic echocardiography 0.0 0 106714 3038
SBH/Ygl heart left ventricle end-systolic diameter to body weight ratio controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. heart left ventricle end-systolic diameter male 98 days 7 0.95 mm/kg 0.09 0.24 transthoracic echocardiography 0.0 0 106723 3038
SBH/Ygl blood glucose level controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. blood glucose amount male 98 days 7 383.4 mg/dl 21.6 57.15 blood glucose test strip read by electrochemical glucometer 0.0 0 106694 3038
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 17 256.0 g 5.0 20.62 body weighing method 0.0 unx 150 days 107446 2378
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 16 3.1 g/kg 0.1 0.4 post excision weight measurement 0.0 unx 150 days 107453 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 19.3 x 10E3 um2 4.8 19.79 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107461 2378
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 17 8.2 mg/g 0.2 0.82 post excision weight measurement 0.0 unx 150 days 107457 2378
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 13.2 x 10E3 um2 3.3 13.61 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107511 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 15.8 x 10E3 um2 4.0 16.0 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107463 2378
SD effective renal plasma flow streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. kidney plasma flow trait male 0 days 8 2.31 ml/min/100g 0.06 0.16 p-aminohippurate analysis by liquid phase colorimetry 0.0 stz 154 days 99906 2358
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 17 6.6 mmHg/ml/min 0.3 1.24 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99997 2378
LH/Mav blood glucose level streptozotocin (75 mg/kg) then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 37 300.0 mg/dl 8.0 48.66 blood glucose analysis 0.0 0 102661 2703
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 10 83.78 mg/dl 6.56 20.76 blood cholesterol analysis 0.0 0 102665 2703
LL/Mav systolic blood pressure streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 112 days 18 mean of 3 samples of undefined duration serial mean 123.0 mmHg 2.0 8.49 tail cuff plethysmography 0.0 0 102727 2721
LH/Mav blood glucose level streptozotocin (75 mg/kg) then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 14 358.0 mg/dl 11.0 41.16 blood glucose analysis 0.0 0 102721 2721
LL/Mav blood glucose level streptozotocin (100 mg/kg) then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 18 337.0 mg/dl 10.0 42.43 blood glucose analysis 0.0 0 102719 2721
LH/Mav timed urine volume streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 112 days 14 11.9 ml/d 0.5 1.87 urine volume measurement method 0.0 0 102733 2721
LL/Mav urine total protein excretion rate streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 112 days 18 35.0 mg/d 2.0 8.49 urine protein analysis 0.0 0 102735 2721
LL/Mav urine albumin level to urine total protein level ratio streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 18 10.4 % 0.4 1.7 urine albumin analysis 0.0 0 102743 2721
SD effective renal plasma flow streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. kidney plasma flow trait male 0 days 8 2.28 ml/min/100g 0.05 0.15 p-aminohippurate analysis by liquid phase colorimetry 0.0 stz 154 days 99905 2358
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 17 44.8 % 0.6 2.47 hematocrit analysis 0.0 unx 168 days 99976 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 16 0.21 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99989 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 16 45.5 ml/d 5.04 20.16 metabolic cage urine volume measurement method 0.0 unx 168 days 100003 2378
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 9 82.24 mg/dl 6.95 20.85 blood cholesterol analysis 0.0 0 102664 2703
LL/Mav blood glucose level streptozotocin (100 mg/kg) then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 18 71.0 mg/dl 1.0 4.24 blood glucose analysis 0.0 0 102715 2721
WKY blood glucose level streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 537.12 mg/dl 28.98 91.64 radioimmunoassay 0.0 0 99105 2219
WKY blood glucose level streptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 533.7 mg/dl 25.56 80.83 radioimmunoassay 0.0 0 99103 2219
WKY body weight streptozotocin (60 mg/kg) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. body mass male 156 days 10 259.65 g 18.96 59.96 body weighing method 0.0 0 99108 2219
WKY body weight streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. body mass male 156 days 10 286.6 g 21.95 69.41 body weighing method 0.0 0 99112 2219
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 308 days) then enalapril (15 mg/l) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 364 days 6 201.08 null 15.0 36.74 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100778 2522
SD left kidney wet weight streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. kidney mass male 0 days 8 2.14 g 0.04 0.12 post excision weight measurement 0.0 stz 224 days 99918 2358
SD blood glucose level streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. blood glucose amount male 0 days 8 358.0 mg/dl 20.86 59.0 blood glucose analysis 0.0 stz 224 days 99920 2358
SD systolic blood pressure streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. arterial blood pressure trait male 0 days 8 undefined 128.0 mmHg 1.06 3.0 tail cuff plethysmography 0.0 stz 224 days 99924 2358
SD glomerular filtration rate to body weight ratio streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. glomerular filtration trait male 0 days 8 0.65 ml/min/100g 0.02 0.06 inulin analysis by thiourea-resorcinol assay 0.0 stz 224 days 99927 2358
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 8 236.0 g 7.0 19.8 body weighing method 0.0 unx 28 days 99937 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.23 null 0.14 0.4 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99958 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 8 23.47 ml/d 1.73 4.89 metabolic cage urine volume measurement method 0.0 unx 28 days 99966 2378
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 427 days 6 2.44 x 10E6 um3 0.21 0.51 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100785 2522
Crl:SD number of podocytes per kidney glomerulus streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. podocyte morphology trait male 427 days 6 178.53 null 22.47 55.04 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 371 days 100790 2522
MNS artery lumen to artery total diameter ratio streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 46.4 % 10.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104151 2907
MHS blood glucose level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood glucose amount male 252 days 14 478.8 mg/dl 12.51 46.8 colorimetry tail vein 0.0 0 104084 2907
MNS blood hemoglobin A1c level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 84 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood hemoglobin amount male 168 days 8 15.4 % 0.53 1.5 affinity chromatography tail vein 0.0 0 affinity chromatography (MMO:0000845) 104091 2907
MHS blood hemoglobin A1c level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 84 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood hemoglobin amount male 168 days 9 15.7 % 0.47 1.4 affinity chromatography tail vein 0.0 0 affinity chromatography (MMO:0000845) 104093 2907
Crl:WI blood hemoglobin A1c level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood hemoglobin amount male 252 days 14 15.5 % 0.29 1.1 affinity chromatography tail vein 0.0 0 affinity chromatography (MMO:0000845) 104099 2907
MHS single kidney wet weight streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney mass male 126 days 6 2.53 g 0.22 0.55 post excision weight measurement 0.0 0 104113 2907
MNS artery diameter streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 25.4 um 8.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104131 2907
SBH/Ygl food intake weight to body weight ratio controlled sodium chloride content diet (8 %) (for 28 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 28 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. eating behavior trait male 84 days 7 15.72 g/d/100g 0.7 1.85 food intake measuring method 0.0 0 106707 3038
SBH/Ygl heart left ventricle fractional shortening controlled sodium chloride content diet (8 %) (for 42 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. heart left ventricle end-diastolic diameter male 98 days 7 65.0 % 1.0 2.65 transthoracic echocardiography 0.0 0 106715 3038
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 17 274.0 g 6.0 24.74 body weighing method 0.0 unx 150 days 107447 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 16.4 x 10E3 um2 4.1 16.4 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107464 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 17.0 x 10E3 um2 4.1 16.9 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107462 2378
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 16 3.1 g/kg 0.1 0.4 post excision weight measurement 0.0 unx 150 days 107454 2378
MNS renal vascular resistance streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. renal blood flow trait male 126 days 6 5.04 mmHg/ml/min 0.24 0.59 inulin analysis by liquid phase colorimetry 0.0 0 104127 2907
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 17 324.0 mg/dl 13.0 53.6 machine read blood glucose test strip 0.0 unx 168 days 99971 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 16 308.0 mg/dl 15.0 60.0 machine read blood glucose test strip 0.0 unx 168 days 99973 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.69 ml/min/100g 0.03 0.13 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99982 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 16 3.15 ml/min/100g 0.13 0.52 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99993 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 16 49.25 ml/d 5.18 20.74 metabolic cage urine volume measurement method 0.0 unx 168 days 100004 2378
WKY single kidney wet weight to body weight ratio streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. kidney mass male 156 days 10 4.73 g/kg 0.37 1.17 post excision weight measurement 0.0 0 99117 2219
LH/Mav urine protein level to urine creatinine level ratio streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. total urine protein amount male 49 days-56 days 37 9.3 null 0.5 3.04 urine protein analysis 0.0 0 102655 2703
LL/Mav systolic blood pressure streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 56 days 18 mean of 3 samples of undefined duration serial mean 124.0 mmHg 3.0 12.73 tail cuff plethysmography 0.0 0 102703 2721
LH/Mav systolic blood pressure streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. arterial blood pressure trait male 49 days-56 days 37 undefined 145.0 mmHg 2.0 12.17 tail cuff plethysmography 0.0 0 102646 2703
MNS mean arterial blood pressure streptozotocin (50 mg/kg) (for 147 days) then insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. arterial blood pressure trait male 213 days 9 111.4 mmHg 4.5 13.5 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 104024 2886
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 6 2.42 ml/min/100g 0.09 0.22 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99954 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 6 0.21 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99959 2378
LL/Mav body weight streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 112 days 18 331.0 g 3.0 12.73 body weighing method 0.0 0 102723 2721
LH/Mav urine albumin level to urine total protein level ratio streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 14 19.6 % 0.7 2.62 urine albumin analysis 0.0 0 102745 2721
LL/Mav urine creatinine excretion rate streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine creatinine amount male 112 days 18 9.8 mg/d 0.3 1.27 urine creatinine analysis 0.0 0 102747 2721
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood creatinine amount male 112 days 14 0.55 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102761 2721
SD body weight streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. body mass male 0 days 8 526.0 g 10.25 29.0 body weighing method 0.0 stz 154 days 99871 2358
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 17 312.0 mg/dl 24.0 98.95 machine read blood glucose test strip 0.0 unx 168 days 99972 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.21 null 0.01 0.05 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99987 2378
MHS urine potassium excretion rate streptozotocin (50 mg/kg) (for 147 days) then insulin (2 IU/d) (for 147 days) Ge Y, et al., Physiol Rep. 2017 Feb;5(3). pii: 5/3/e13089. doi: 10.14814/phy2.13089. urine potassium amount male 213 days 6 4.29 mEq/d 0.53 1.3 urine potassium analysis 0.0 0 104033 2886
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 11 73.36 mg/dl 4.63 15.37 blood cholesterol analysis 0.0 0 102666 2703
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 7 24.2 mg/g 0.3 0.79 post excision weight measurement 0.0 0 102685 2703
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 11 6.44 g/kg 0.14 0.46 post excision weight measurement 0.0 0 102696 2703
WKY blood glucose level streptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 523.26 mg/dl 27.18 85.95 radioimmunoassay 0.0 0 99104 2219
WKY single kidney wet weight to body weight ratio streptozotocin (60 mg/kg) then benazepril (10 mg/kg/d) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. kidney mass male 156 days 10 4.72 g/kg 0.31 0.98 post excision weight measurement 0.0 0 99118 2219
WKY timed urine volume streptozotocin (60 mg/kg) then gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector (40000000000 PFU) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. urine output male 156 days 10 133.86 ml/d 16.58 52.43 urine volume measurement method 0.0 0 99121 2219
WKY timed urine volume streptozotocin (60 mg/kg) then gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector (40000000000 PFU) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. urine output male 156 days 10 62.68 ml/d 15.67 49.55 urine volume measurement method 0.0 0 99122 2219
SD blood glucose level streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. blood glucose amount male 0 days 8 343.0 mg/dl 18.38 52.0 blood glucose analysis 0.0 stz 154 days 99897 2358
SD systolic blood pressure streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. arterial blood pressure trait male 0 days 8 undefined 128.0 mmHg 1.06 3.0 tail cuff plethysmography 0.0 stz 154 days 99900 2358
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 308 days) then enalapril (15 mg/l) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 364 days 6 2.06 x 10E6 um3 0.14 0.34 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100774 2522
Crl:SD kidney glomerulus volume streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 175 days) Benigni A, et al., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. kidney glomerulus morphology trait male 364 days 6 3.14 x 10E6 um3 0.19 0.47 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 stz 308 days 100772 2522
SD renal filtration fraction streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. glomerular filtration trait male 0 days 8 0.3 null 0.01 0.03 p-aminohippurate analysis by liquid phase colorimetry 0.0 stz 154 days GFR by inulin method 99911 2358
SD blood glucose level streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. blood glucose amount male 0 days 8 350.0 mg/dl 19.09 54.0 blood glucose analysis 0.0 stz 224 days 99921 2358
SD renal filtration fraction streptozotocin (60 mg/kg) then insulin then Moexipril (30-35 mg/kg/d) (for 112 days) Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. glomerular filtration trait male 0 days 8 0.29 null 0.01 0.02 p-aminohippurate analysis by liquid phase colorimetry 0.0 stz 224 days GFR by inulin method 99933 2358
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 6 367.0 mg/dl 12.0 29.39 machine read blood glucose test strip 0.0 unx 28 days 99944 2378
MHS artery tunica media to artery total diameter ratio streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 31.4 % 4.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104145 2907
MHS artery inner diameter streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 10.1 um 4.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104149 2907
MHS body weight streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. body mass male 252 days 14 337.0 g 12.56 47.0 body weighing method 0.0 0 104071 2907
MHS blood glucose level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 84 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood glucose amount male 168 days 9 462.6 mg/dl 19.8 59.4 colorimetry tail vein 0.0 0 104080 2907
MNS blood glucose level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 84 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood glucose amount male 168 days 8 453.6 mg/dl 15.91 45.0 colorimetry tail vein 0.0 0 104078 2907
Crl:WI blood glucose level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood glucose amount male 252 days 14 473.4 mg/dl 10.1 37.8 colorimetry tail vein 0.0 0 104086 2907
MHS blood hemoglobin A1c level streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. blood hemoglobin amount male 252 days 17 15.7 % 0.75 3.1 affinity chromatography tail vein 0.0 0 affinity chromatography (MMO:0000845) 104097 2907
MNS single kidney wet weight streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney mass male 126 days 6 3.08 g 0.13 0.31 post excision weight measurement 0.0 0 104111 2907
MNS renal filtration fraction streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. glomerular filtration trait male 126 days 6 ((A-V)/A)*100 0.31 null 0.0 0.01 inulin analysis by liquid phase colorimetry 0.0 0 filtration fraction 104119 2907
SBH/Ygl systolic blood pressure controlled sodium chloride content diet (0.65 %) (for 98 days) then streptozotocin (60 mg/kg) then insulin (10 ul) (for 42 days) Landau D, et al., J Endocrinol. 2008 Apr;197(1):75-83. doi: 10.1677/JOE-08-0040. arterial blood pressure trait male 98 days 7 128.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 0 106698 3038
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 17 3.5 g/kg 0.1 0.41 post excision weight measurement 0.0 unx 150 days 107451 2378
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 16 261.0 g 7.0 28.0 body weighing method 0.0 unx 150 days 107448 2378
MHS artery diameter streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 168 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. kidney blood vessel morphology trait male 252 days 0 26.7 um 8.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104133 2907
MHS renal filtration fraction streptozotocin (55 mg/kg) then insulin (4 IU/kg) (for 42 days) Pugliese G, et al., Kidney Int. 2005 Apr;67(4):1440-52. doi: 10.1111/j.1523-1755.2005.00221.x. glomerular filtration trait male 126 days 6 ((A-V)/A)*100 0.25 null 0.0 0.01 inulin analysis by liquid phase colorimetry 0.0 0 filtration fraction 104121 2907
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood triglyceride amount male 112 days 14 2.95 mmol/l 0.27 1.01 plasma triglyceride analysis 0.0 0 102757 2721
LL/Mav aorta weight to body weight ratio streptozotocin (100 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. aorta mass male 112 days 18 12.2 mg/100g 0.3 1.27 post excision weight measurement 0.0 0 102771 2721
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 16 45.8 % 0.5 2.0 hematocrit analysis 0.0 unx 168 days 99978 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.29 null 0.01 0.05 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99986 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 16 0.67 ml/min/100g 0.02 0.08 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99984 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 17 39.46 ml/d 4.61 19.0 metabolic cage urine volume measurement method 0.0 unx 168 days 100001 2378
SD blood glucose level streptozotocin (60 mg/kg) then insulin Perico N, et al., J Am Soc Nephrol. 1994 Oct;5(4):1139-46. blood glucose amount male 0 days 8 334.0 mg/dl 19.8 56.0 blood glucose analysis 0.0 stz 154 days 99896 2358
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 8 38.02 ml/d 5.33 15.07 metabolic cage urine volume measurement method 0.0 unx 28 days 99967 2378