Phenominer Database Results (24 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 -7.39 null 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55282 522
SS-Chr 5BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 -6.78 null 0.1 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55632 522
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 1.93 E-7mole 0.35 0.98 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55901 522
SS-Chr 5BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54908 522
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 7 1.59 mg/kg 0.55 1.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58901 526
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 1.52 E-7mole 0.22 0.64 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56527 522
SS-Chr 5BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 -6.87 null 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56922 522
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 1.06 mg/kg 0.12 0.32 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58904 526
SS-Chr 5BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 -6.88 null 0.03 0.1 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56917 522
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 -7.52 null 0.13 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55277 522
SS-Chr 5BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 -7.06 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55627 522
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 0.98 E-7mole 0.17 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55896 522
SS-Chr 5BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.06 umol/l 0.02 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54681 522
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 88.13 % 6.08 17.19 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54787 522
SS-Chr 5BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 1.34 E-7mole 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56522 522
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 87.91 % 3.41 11.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54782 522
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 91.8 % 2.85 9.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57226 522
SS-Chr 5BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 86.38 % 8.85 25.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57231 522
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 8 1.2 mg/kg 0.23 0.66 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59176 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 9 0.97 mg/kg 0.16 0.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59180 526
SS-Chr 5BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 7 0.05 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54913 522
SS-Chr 5BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.04 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54676 522
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 -7.81 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56107 522
SS-Chr 5BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 7 -7.35 null 0.08 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56112 522