Phenominer Database Results (537 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 133 days 19 32.4 U/l 0.99 4.3 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85437 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 8 24.6 g/d 0.21 0.6 unspecified method 0.0 0 85471 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 8 6.04 g/d/100g 0.23 0.66 unspecified method 0.0 0 on days 11-14 85493 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 8 3.96 g/d/100g 0.35 0.98 unspecified method 0.0 0 on days 95-98 85516 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105 days 8 472.0 g 8.49 24.0 body weighing method 0.0 0 85532 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 19 5.78 g/d/100g 0.1 0.42 unspecified method 0.0 0 85300 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 19 4.74 g/d/100g 0.11 0.5 unspecified method 0.0 0 85304 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147 days 19 563.0 g 13.54 59.0 body weighing method 0.0 0 85318 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105 days 19 374.0 g 5.28 23.0 body weighing method 0.0 0 85315 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 78 days 19 130.0 mg/dl 1.84 8.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85324 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 147 days 19 129.0 mg/dl 0.92 4.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85334 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 70 days 19 14.7 mg/dl 1.1 4.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85355 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 78 days 19 21.1 mg/dl 1.08 4.7 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85356 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 147 days 19 17.0 mg/dl 1.24 5.4 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85366 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 133 days 19 30.2 mg/dl 2.87 12.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85365 1604
Crl:CD(SD) urine taurine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 70 days 19 68.7 umol/d 8.69 37.9 liquid chromatography-mass spectrometry 0.0 0 85394 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 70 days 19 60.7 U/l 1.19 5.2 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85410 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 91 days 19 35.4 U/l 1.49 6.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85431 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 78 days 19 13.7 U/l 0.48 2.1 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85444 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 91 days 19 15.5 U/l 0.62 2.7 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85447 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 8 20.3 g/d 1.06 3.0 unspecified method 0.0 0 85462 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 8 18.8 g/d 0.92 2.6 unspecified method 0.0 0 85463 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 8 18.3 g/d 1.98 5.6 unspecified method 0.0 0 85486 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 8 5.68 g/d/100g 0.06 0.17 unspecified method 0.0 0 on days 11-14 85490 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 8 5.12 g/d/100g 0.15 0.42 unspecified method 0.0 0 on days 32-35 85496 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 8 5.09 g/d/100g 0.24 0.67 unspecified method 0.0 0 on days 32-35 85498 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105 days 8 375.0 g 12.73 36.0 body weighing method 0.0 0 85534 1604
Crl:CD(SD) plasma acetaminophen level area under curve standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 373.9 (ug/ml) x h 38.93 110.1 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 4-19 hr dosing 4-19 hr dosing 85588 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 70 days 19 143.0 mg/dl 1.38 6.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85322 1604
Crl:CD(SD) urine creatinine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 70 days 19 7.64 mg/d 0.27 1.17 liquid chromatography-mass spectrometry 0.0 0 85387 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 19 4.01 g/d/100g 0.27 1.17 unspecified method 0.0 0 85309 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84 days 19 419.0 g 8.72 38.0 body weighing method 0.0 0 85312 1604
Crl:CD(SD) urine creatine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 134 days 19 2.44 umol/d 0.08 0.37 liquid chromatography-mass spectrometry 0.0 0 85382 1604
Crl:CD(SD) urine taurine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 169 days 19 153.1 umol/d 7.75 33.8 liquid chromatography-mass spectrometry 0.0 0 85401 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 8 4.24 g/d/100g 0.06 0.18 unspecified method 0.0 0 on days 95-98 85514 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 105 days 19 13.5 U/l 0.21 0.9 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85449 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 8 24.9 g/d 0.85 2.4 unspecified method 0.0 0 85472 1604
Jcl:WI heart left ventricle weight to body weight ratio standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. heart left ventricle mass male 84 days 8 1.85 mg/g 0.03 0.09 post excision weight measurement 0.0 0 103067 2785
GK/Jcl heart left ventricle weight to body weight ratio standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. heart left ventricle mass male 84 days 8 1.95 mg/g 0.01 0.03 post excision weight measurement 0.0 0 103069 2785
SR/Hsd mean arterial blood pressure standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. arterial blood pressure trait male 49 days 8 120.0 mmHg 1.06 3.0 tail cuff plethysmography 0.0 0 102267 2683
WKY blood very low density lipoprotein triglyceride level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood VLDL triglyceride amount male 0 days 7 0.96 mg/dl 0.2 0.53 enzymatic triglyceride assay 0.0 0 98922 2178
SR/Hsd plasma urotensin II level standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. blood urotensin II amount male 49 days 8 61.0 pg/ml 2.09 5.9 radioimmunoassay 0.0 0 102275 2683
SR/Hsd urine sodium level standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. urine sodium amount male 49 days 8 0.3 mmol/l 0.04 0.1 urine sodium analysis 0.0 0 102281 2683
SS creatinine clearance standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. glomerular filtration trait male 49 days 8 4.2 ml/min 0.25 0.7 urine creatinine analysis 0.0 0 102286 2683
WI systolic blood pressure controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. arterial blood pressure trait male 102 days 21 mean of 3 samples of undefined duration serial mean 119.0 mmHg 0.75 3.44 tail cuff plethysmography 0.0 0 101055 2563
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 112 and 126 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 140 days-168 days 8 145.2 mg/dl 23.6 66.74 serum glucose analysis 0.0 0 101505 2601
WI plasma triglyceride level controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood triglyceride amount male 102 days 6 0.62 mmol/l 0.08 0.2 plasma triglyceride analysis 0.0 0 101069 2563
WI plasma total cholesterol level controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood cholesterol amount male 102 days 6 38.83 mg/dl 3.19 7.81 plasma total cholesterol measurement test 0.0 0 101071 2563
SD-Abcc6em2Qlju+/- serum phosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood phosphate amount female 60 days-180 days 5 5.7 mg/dl 0.1 0.22 liquid phase colorimetry 0.0 0 104645 2972
SD-Abcc6em2Qlju+/- serum calcium to serum phosphate ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount male 60 days-180 days 5 1.44 null 0.08 0.18 colorimetry 0.0 0 104650 2972
SD-Abcc6em2Qlju-/- plasma pyrophosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount female 60 days-180 days 5 0.24 umol/l 0.05 0.11 enzymatic method 0.0 0 104659 2972
SD-Abcc6em2Qlju-/- serum phosphate level to plasma pyrophosphate level ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount male 60 days-180 days 5 2082.3 null 626.9 1401.79 liquid phase colorimetry 0.0 0 104664 2972
MHS timed urine volume standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. urine output male 63 days 10 14.0 ml/d 0.97 3.08 urine volume measurement method 0.0 0 104169 2927
MHS timed urine volume standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. urine output male 270 days 10 15.2 ml/d 1.23 3.9 urine volume measurement method 0.0 0 104172 2927
MNS serum creatinine level standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. blood creatinine amount male 63 days 10 0.31 mg/dl 0.01 0.02 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104174 2927
Crl:WI serum creatinine level standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. blood creatinine amount male 63 days 10 0.39 mg/dl 0.01 0.03 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104179 2927
MNS urine total protein excretion rate standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. total urine protein amount male 270 days 10 604.98 mg/d 50.69 160.29 urine protein analysis 0.0 0 104189 2927
MHS urine total protein excretion rate standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. total urine protein amount male 270 days 10 19.78 mg/d 1.92 6.07 urine protein analysis 0.0 0 104190 2927
MNS body weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. body mass male 63 days 10 270.8 g 4.3 13.6 body weighing method 0.0 0 104192 2927
MHS left kidney wet weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 63 days 10 0.76 g 0.01 0.02 post excision weight measurement 0.0 0 104199 2927
MHS artery diameter standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 34.3 um 0.85 2.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104211 2927
MWF/Ztm urine total protein excretion rate standard diet Remuzzi A, etal., Kidney Int. 1988 Oct;34(4):481-6. doi: 10.1038/ki.1988.206. urine protein amount female 147 days 5 25.0 mg/d 5.81 13.0 Bradford protein assay 0.0 0 109202 3138
MWF/Ztm total filtering surface area per glomerulus standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. kidney glomerulus morphology trait male 252 days-253 days 5 NA 0.34 mm2 0.02 0.04 ex vivo electron microscopy with digital image analysis renal glomerulus 0.0 0 109165 3136
MWF/Ztm mean length density of glomerular capillaries standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. glomerular capillary morphology trait male 252 days-253 days 5 2xNcap/k2xPr, Ncap is number of capillary profiles, k2 is ratio between the distance (In micrometers) of two adjacent grid points and the magnification, Pr is grid points falling Into the glomerular tuft 13.0 REQUEST NEW VALUE 1.3 2.9 ex vivo electron microscopy with digital image analysis renal glomerulus 0.0 0 109178 3136
MWF/Fub body weight standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. body mass male 104 days 8 319.0 g 7.1 20.08 body weighing method 0.0 0 109001 3134
LEW/Mol kidney wet weight to body weight ratio standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. kidney mass female 104 days 8 3.74 mg/g 0.09 0.25 post excision weight measurement kidney 0.0 0 109012 3134
MWF/Ztm urine total protein excretion rate standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. total urine protein amount male 210 days 10 325.0 mg/d 27.2 86.0 Bradford protein assay 0.0 0 109981 3162
SHRSP/A3NCrl partial pressure of brain white matter oxygen standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 112 days 6 25.6 mmHg 1.2 2.94 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds vascular cognitive impairment 107318 3080
LEW/Mol body weight standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. body mass female 104 days 8 193.0 g 2.6 7.35 body weighing method 0.0 0 108996 3134
MWF/Fub body weight standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. body mass female 104 days 8 193.0 g 2.8 7.92 body weighing method 0.0 0 109000 3134
MWF/Fub kidney wet weight to body weight ratio standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. kidney mass male 104 days 8 2.87 mg/g 0.05 0.14 post excision weight measurement kidney 0.0 0 109017 3134
SD-Ldlrem1Sage plasma aspartate aminotransferase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood aspartate transaminase amount male 448 days 8 112.0 U/l 18.0 50.91 automated plasma aspartate aminotransferase activity assay 0.0 0 138290 3201
SD-Ldlrem1Sage blood very low density lipoprotein particle diameter standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood VLDL particle size male 448 days 8 35.8 nm 0.1 0.28 nuclear magnetic resonance spectroscopy 0.0 0 138331 3201
Hsd:SD plasma creatinine level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood creatinine amount male 448 days 9 0.59 mg/dl 0.04 0.12 automated plasma creatinine analysis 0.0 0 138298 3201
SD-Ldlrem1Sage plasma leptin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood leptin amount male 448 days 8 28.18 ng/ml 4.14 11.71 enzyme linked immunosorbent assay 0.0 0 138315 3201
SD-Ldlrem1Sage plasma adiponectin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood adiponectin amount male 448 days 8 48.4 ug/ml 5.6 15.84 enzyme linked immunosorbent assay 0.0 0 138319 3201
SD-Ldlrem1Sage plasma chylomicron and VLDL cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 8 178.0 mg/dl 26.0 73.54 blood cholesterol analysis 0.0 0 138462 3201
Hsd:SD plasma IDL and LDL cholesterol standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 9 94.0 mg/dl 16.0 48.0 blood cholesterol analysis 0.0 0 138461 3201
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 70 days 19 0.54 mg/dl 0.03 0.15 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85338 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 105 days 19 15.0 mg/dl 0.48 2.1 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85360 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 147 days 19 19.4 mg/dl 0.78 3.4 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85367 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 78 days 19 18.7 mg/dl 1.28 5.6 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85357 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147 days 8 557.0 g 8.13 23.0 body weighing method 0.0 0 85543 1604
Crl:CD(SD) plasma acetaminophen level standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 2.4 ug/ml 0.71 2.0 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 19 hr after dosing 85585 1604
Crl:CD(SD) plasma acetaminophen level standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 49.3 ug/ml 5.62 15.9 high-performance liquid chromatography 0.0 acetaminophen dosing 240 min 4 hr after dosing 85580 1604
WI systolic blood pressure controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. arterial blood pressure trait male 102 days 35 mean of 3 samples of undefined duration serial mean 135.7 mmHg 0.35 2.07 tail cuff plethysmography 0.0 0 101056 2563
WI urine sodium excretion rate controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. urine sodium amount male 102 days 6 25.67 mEq/d 3.55 8.7 urine sodium analysis 0.0 0 101061 2563
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147 days 8 431.0 g 8.49 24.0 body weighing method 0.0 0 85547 1604
MHS creatinine clearance standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. glomerular filtration trait male 270 days 10 0.97 ml/min 0.02 0.05 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104184 2927
MHS body weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. body mass male 270 days 10 538.6 g 6.77 21.4 body weighing method 0.0 0 104196 2927
Crl:WI left kidney wet weight to body weight ratio standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 270 days 10 2.9 mg/g 0.09 0.3 post excision weight measurement 0.0 0 104209 2927
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 119 days 19 0.94 mg/dl 0.09 0.39 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85347 1604
GK/Jcl blood total cholesterol level standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. blood cholesterol amount male 84 days 8 83.01 mg/dl 0.96 2.7 blood cholesterol analysis 0.0 0 103081 2785
Crl:CD(SD) urine taurine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 134 days 19 171.1 umol/d 13.08 57.0 liquid chromatography-mass spectrometry 0.0 0 85399 1604
Crl:CD(SD) liver wet weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170 days 19 17.65 g 0.54 2.35 unspecified method 0.0 0 liver weight not available 85402 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 119 days 19 56.4 U/l 2.13 9.3 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85418 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 70 days 19 15.9 U/l 1.17 5.1 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85443 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 8 4.9 g/d/100g 0.18 0.5 unspecified method 0.0 0 on days 32-35 85499 1604
HTG plasma total cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood cholesterol amount male 0 days 7 60.62 mg/dl 3.09 8.17 enzymatic cholesterol assay 0.0 0 98904 2178
HTG plasma low density lipoprotein cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood LDL cholesterol amount male 0 days 7 14.67 mg/dl 1.54 4.09 enzymatic cholesterol assay 0.0 0 98912 2178
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 168 days 19 48.1 U/l 0.69 3.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85425 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 147 days 19 36.4 U/l 0.62 2.7 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85438 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 147 days 19 16.1 U/l 0.69 3.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85454 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 8 17.9 g/d 1.77 5.0 unspecified method 0.0 0 85480 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 1 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71 days 8 287.0 g 5.3 15.0 body weighing method 0.0 0 85523 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 1 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71 days 8 375.0 g 6.36 18.0 body weighing method 0.0 0 85520 1604
Crl:CD(SD) liver wet weight standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170 days 8 20.3 g 0.7 1.98 unspecified method 0.0 0 liver weight not available 85556 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 91 days 19 18.8 mg/dl 0.53 2.3 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85358 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 119 days 19 33.2 mg/dl 3.4 14.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85363 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 19 7.12 umol/g 0.07 0.31 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85406 1604
Crl:CD(SD) urine taurine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 106 days 19 137.6 umol/d 8.44 36.8 liquid chromatography-mass spectrometry 0.0 0 85396 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 19 6.1 umol/g 0.15 0.67 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method 85407 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 91 days 19 59.7 U/l 0.8 3.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85415 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 133 days 19 57.1 U/l 2.18 9.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85420 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 105 days 19 34.9 U/l 1.1 4.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85432 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 119 days 19 37.8 U/l 0.87 3.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85434 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 8 17.7 g/d 1.31 3.7 unspecified method 0.0 0 85481 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168 days 8 440.0 g 9.19 26.0 body weighing method 0.0 0 85553 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 19 24.5 g/d 0.37 1.6 unspecified method 0.0 0 85291 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 19 4.07 g/d/100g 0.05 0.2 unspecified method 0.0 0 85308 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 78 days 19 126.0 mg/dl 2.06 9.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85325 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 105 days 19 121.0 mg/dl 1.61 7.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85329 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 91 days 19 124.0 mg/dl 2.29 10.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85327 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 147 days 19 126.0 mg/dl 1.84 8.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85335 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 168 days 19 0.44 mg/dl 0.01 0.06 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85352 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 168 days 19 0.56 mg/dl 0.03 0.15 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85353 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 105 days 19 23.5 mg/dl 2.29 10.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85361 1604
Crl:CD(SD) urine creatine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 169 days 19 2.11 umol/d 0.11 0.48 liquid chromatography-mass spectrometry 0.0 0 85384 1604
Crl:CD(SD) urine creatine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 169 days 19 2.06 umol/d 0.12 0.51 liquid chromatography-mass spectrometry 0.0 0 85385 1604
Crl:CD(SD) liver wet weight standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170 days 19 11.09 g 0.16 0.71 unspecified method 0.0 0 85403 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 91 days 19 33.3 U/l 0.87 3.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85430 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 133 days 19 17.0 U/l 0.71 3.1 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85452 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 8 16.7 g/d 0.95 2.7 unspecified method 0.0 0 85469 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 8 6.04 g/d/100g 0.21 0.58 unspecified method 0.0 0 on days 11-14 85492 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 8 0.19 umol/g 0.01 0.03 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85574 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 119 days 19 127.0 mg/dl 1.84 8.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85331 1604
Crl:CD(SD) plasma acetaminophen level standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 0.3 ug/ml 0.18 0.5 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 19 hr after dosing 85582 1604
Crl:CD(SD) plasma acetaminophen level standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 88.0 ug/ml 3.89 11.0 high-performance liquid chromatography 0.0 acetaminophen dosing 240 min 4 hr after dosing 85578 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 8 6.24 umol/g 0.31 0.87 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method 85570 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 8 4.03 g/d/100g 0.29 0.81 unspecified method 0.0 0 on days 74-77 85511 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84 days 8 418.0 g 6.72 19.0 body weighing method 0.0 0 85525 1604
Jcl:WI heart weight standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. heart mass male 84 days 8 1.14 g 0.03 0.09 post excision weight measurement 0.0 0 103059 2785
Jcl:WI blood glucose level standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. blood glucose amount male 84 days 8 162.36 mg/dl 16.1 45.54 blood glucose analysis 0.0 0 103071 2785
SS body weight standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. body mass male 49 days 8 208.0 g 2.72 7.7 body weighing method 0.0 0 102270 2683
WKY liver triglyceride level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. liver triglyceride amount male 0 days 7 11.42 mg/g 1.08 2.86 enzymatic triglyceride assay 0.0 0 98898 2178
HTG plasma high density lipoprotein cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood HDL cholesterol amount male 0 days 7 31.27 mg/dl 2.32 6.13 enzymatic cholesterol assay 0.0 0 98916 2178
SS urine sodium level standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. urine sodium amount male 49 days 8 0.5 mmol/l 0.07 0.2 urine sodium analysis 0.0 0 102280 2683
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 168 days-196 days 8 130.68 mg/dl 21.78 61.6 serum glucose analysis 0.0 0 101508 2601
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 112 and 126 days) then perindopril (0.25-0.5 mg/kg/d) (between 56 and 70 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 140 days-168 days 8 179.69 mg/dl 21.78 61.6 serum glucose analysis 0.0 0 101506 2601
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 168 days-196 days 8 139.76 mg/dl 18.15 51.34 serum glucose analysis 0.0 0 101509 2601
SHR/N-cp both kidneys wet weight to body weight ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney mass male 168 days-196 days 8 1.67 g/kg 0.1 0.28 post excision weight measurement 0.0 0 101524 2601
SHR/N-cp kidney sclerotic glomeruli count to total glomeruli count ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney glomerulus integrity trait male 168 days-196 days 8 16.0 % 3.0 8.49 ex vivo light microscopy with histochemistry 0.0 0 101526 2601
SHR/N-cp plasma renin activity level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. renin activity male 140 days-168 days 8 38.0 ng/ml/h 2.0 5.66 radioimmunoassay 0.0 0 101534 2601
WI urine sodium excretion rate controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. urine sodium amount male 102 days 6 35.17 mEq/d 6.7 16.41 urine sodium analysis 0.0 0 101062 2563
SD-Lepem1Sage+/+ blood glucose level fasting (for 16 hours) then standard diet (for 1 hours) D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. blood glucose amount male 91 days 6 109.08 mg/dl 3.6 8.82 blood glucose test strip read by electrochemical glucometer 0.0 0 104470 2949
SD-Abcc6em2Qlju+/+ serum calcium to serum phosphate ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount male 60 days-180 days 5 1.56 null 0.06 0.13 colorimetry 0.0 0 104648 2972
SD-Abcc6em2Qlju+/+ plasma pyrophosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount female 60 days-180 days 5 0.77 umol/l 0.11 0.25 enzymatic method 0.0 0 104655 2972
SD-Abcc6em2Qlju+/- plasma pyrophosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount male 60 days-180 days 5 0.61 umol/l 0.08 0.18 enzymatic method 0.0 0 104656 2972
MNS timed urine volume standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. urine output male 270 days 10 14.4 ml/d 1.56 4.93 urine volume measurement method 0.0 0 104171 2927
MHS body weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. body mass male 63 days 10 235.0 g 1.87 5.9 body weighing method 0.0 0 104194 2927
MHS body weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. body mass male 63 days 10 544.4 g 11.45 36.2 body weighing method 0.0 0 104197 2927
MHS left kidney wet weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 270 days 10 1.13 g 0.02 0.07 post excision weight measurement 0.0 0 104202 2927
MNS artery diameter standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 35.8 um 1.55 4.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104210 2927
MWF/Ztm total pericapillary slit length standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. podocyte morphology trait male 252 days-253 days 5 786.37 mm 54.38 121.6 ex vivo electron microscopy with digital image analysis 0.0 0 109183 3136
MWF/Ztm mesangium volume per glomerulus standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. kidney glomerulus morphology trait male 252 days-253 days 5 Pc/Pr, number of grid points falling into the component (Pc: mesangial cells and matrix) and the number of points falling into the reference area (Pr. i.e., the glomerular tuft 0.21 x 10E-6 um3 0.02 0.04 ex vivo electron microscopy with digital image analysis renal glomerulus 0.0 0 mesangium volume per glomerulus (CMO:0003716) 109172 3136
MWF/Ztm podocyte foot process width standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. podocyte morphology trait male 131 days 6 227.0 nm 7.76 19.0 ex vivo electron microscopy with digital image analysis 0.0 0 109186 3136
MWF/Ztm systolic blood pressure standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. arterial blood pressure trait male 140 days 10 150.0 mmHg 6.64 21.0 tail cuff plethysmography 0.0 0 109977 3162
MWF/Ztm systolic blood pressure standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. arterial blood pressure trait male 140 days 7 153.0 mmHg 5.67 15.0 tail cuff plethysmography 0.0 0 109978 3162
MWF/Fub kidney wet weight to body weight ratio standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. kidney mass female 104 days 8 2.82 mg/g 0.07 0.2 post excision weight measurement kidney 0.0 0 109016 3134
SHRSP/A3NCrl partial pressure of brain white matter oxygen standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 91 days 6 24.2 mmHg 1.2 2.94 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds vascular cognitive impairment 107315 3080
MWF/Fub kidney weight standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. kidney mass male 104 days 8 0.91 g 0.03 0.08 post excision weight measurement kidney 0.0 0 109009 3134
Hsd:SD plasma albumin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood albumin amount male 448 days 9 0.36 g/l 0.01 0.02 automated plasma albumin analysis 0.0 0 138276 3201
Hsd:SD plasma alanine aminotransferase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood alanine transaminase amount male 448 days 9 54.0 U/l 6.0 18.0 automated plasma alanine aminotransferase activity assay 0.0 0 138285 3201
SD-Ldlrem1Sage plasma creatine kinase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood creatine kinase amount male 448 days 8 354.0 U/l 90.0 254.56 automated plasma creatine kinase activity assay 0.0 0 CK 138295 3201
SD-Ldlrem1Sage liver triglyceride level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. liver triglyceride amount male 448 days 8 25.76 mg/g 5.72 16.18 isolated tissue triglyceride measurement test 0.0 0 138347 3201
Hsd:SD liver cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. liver cholesterol amount male 448 days 9 5.39 mg/g 0.14 0.42 isolated tissue cholesterol measurement test 0.0 0 138342 3201
Hsd:SD plasma adiponectin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood adiponectin amount male 448 days 9 82.96 ug/ml 4.73 14.19 enzyme linked immunosorbent assay 0.0 0 138318 3201
SD-Ldlrem1Sage plasma high density lipoprotein cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 8 73.0 mg/dl 6.0 16.97 blood cholesterol analysis 0.0 0 138327 3201
SD-Ldlrem1Sage plasma IDL and LDL cholesterol standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 8 168.0 mg/dl 8.0 22.63 blood cholesterol analysis 0.0 0 138463 3201
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 19 4.62 g/d/100g 0.13 0.56 unspecified method 0.0 0 85305 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71 days 19 373.0 g 4.59 20.0 body weighing method 0.0 0 85310 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 133 days 19 134.0 mg/dl 1.15 5.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85332 1604
Crl:CD(SD) plasma creatinine level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 168 days 19 0.43 mg/dl 0.0 0.01 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85376 1604
Crl:CD(SD) urine creatine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 70 days 19 1.05 umol/d 0.04 0.19 liquid chromatography-mass spectrometry 0.0 0 85379 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126 days 8 404.0 g 12.37 35.0 body weighing method 0.0 0 85540 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 8 9.07 umol/g 0.25 0.72 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85568 1604
WI serum sodium level controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood sodium amount male 102 days 6 126.67 mmol/l 1.31 3.21 automated serum sodium test 0.0 0 101058 2563
WI serum urea nitrogen level controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood urea nitrogen amount male 102 days 6 37.33 mg/dl 2.68 6.56 serum urea nitrogen analysis 0.0 0 101067 2563
WI urine potassium excretion rate controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. urine potassium amount male 102 days 6 73.83 mEq/d 6.23 15.26 urine potassium analysis 0.0 0 101064 2563
SD-Abcc6em2Qlju+/+ serum phosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood phosphate amount female 60 days-180 days 5 5.9 mg/dl 0.2 0.45 liquid phase colorimetry 0.0 0 104643 2972
SD-Abcc6em2Qlju+/- plasma pyrophosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount female 60 days-180 days 5 0.53 umol/l 0.04 0.09 enzymatic method 0.0 0 104657 2972
Crl:WI timed urine volume standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. urine output male 63 days 10 14.8 ml/d 1.35 4.27 urine volume measurement method 0.0 0 104170 2927
SS plasma urotensin II level standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. blood urotensin II amount male 49 days 8 51.0 pg/ml 0.85 2.4 radioimmunoassay 0.0 0 102274 2683
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168 days 19 588.0 g 14.45 63.0 body weighing method 0.0 0 85320 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 147 days 19 0.68 mg/dl 0.1 0.42 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85351 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 119 days 19 36.8 U/l 1.19 5.2 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85435 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 8 4.34 g/d/100g 0.34 0.96 unspecified method 0.0 0 on days 95-98 85517 1604
HTG plasma very low density lipoprotein cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood VLDL cholesterol amount male 0 days 7 4.25 mg/dl 1.16 3.06 enzymatic cholesterol assay 0.0 0 98908 2178
WKY plasma high density lipoprotein cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood HDL cholesterol amount male 0 days 7 28.57 mg/dl 1.16 3.06 enzymatic cholesterol assay 0.0 0 98914 2178
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 133 days 19 35.9 U/l 0.87 3.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85436 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 168 days 19 14.3 U/l 0.8 3.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85456 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 133 days 19 13.4 U/l 0.3 1.3 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85453 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 8 4.37 g/d/100g 0.23 0.66 unspecified method 0.0 0 on days 74-77 85510 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84 days 8 413.0 g 6.01 17.0 body weighing method 0.0 0 85526 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147 days 8 549.0 g 12.73 36.0 body weighing method 0.0 0 85544 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 19 17.0 g/d 0.73 3.2 unspecified method 0.0 0 85292 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105 days 19 481.0 g 11.7 51.0 body weighing method 0.0 0 85314 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 70 days 19 0.57 mg/dl 0.04 0.18 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85339 1604
Crl:CD(SD) plasma creatinine level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 105 days 19 0.38 mg/dl 0.0 0.02 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85372 1604
Crl:CD(SD) urine creatine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 70 days 19 1.67 umol/d 0.05 0.22 liquid chromatography-mass spectrometry 0.0 0 85378 1604
Crl:CD(SD) plasma creatinine level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 168 days 19 0.46 mg/dl 0.0 0.02 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85377 1604
Crl:CD(SD) urine creatine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 106 days 19 2.22 umol/d 0.07 0.31 liquid chromatography-mass spectrometry 0.0 0 85380 1604
Crl:CD(SD) urine creatinine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 134 days 19 12.5 mg/d 0.25 1.11 liquid chromatography-mass spectrometry 0.0 0 85391 1604
Crl:CD(SD) urine taurine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 70 days 19 58.1 umol/d 5.41 23.6 liquid chromatography-mass spectrometry 0.0 0 85395 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 19 0.17 umol/g 0.0 0.02 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method 85409 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 105 days 19 58.4 U/l 1.06 4.6 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85417 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 105 days 19 34.0 U/l 1.35 5.9 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85433 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 91 days 19 14.4 U/l 1.19 5.2 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85446 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 8 24.1 g/d 0.53 1.5 unspecified method 0.0 0 85459 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 119 days 19 15.0 U/l 0.55 2.4 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85451 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 147 days 19 13.4 U/l 0.41 1.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85455 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 8 5.2 g/d/100g 0.07 0.21 unspecified method 0.0 0 on days 32-35 85495 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126 days 8 522.0 g 8.13 23.0 body weighing method 0.0 0 85537 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 1 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71 days 8 287.0 g 6.72 19.0 body weighing method 0.0 0 85522 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168 days 8 581.0 g 9.19 26.0 body weighing method 0.0 0 85549 1604
Crl:CD(SD) liver wet weight standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170 days 8 20.1 g 0.47 1.33 unspecified method 0.0 0 liver weight not available 85555 1604
Crl:CD(SD) plasma acetaminophen level standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 0.6 ug/ml 0.21 0.6 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 19 hr after dosing 85584 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 19 24.8 g/d 0.53 2.3 unspecified method 0.0 0 85294 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 19 24.7 g/d 0.48 2.1 unspecified method 0.0 0 85290 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 19 6.11 g/d/100g 0.1 0.45 unspecified method 0.0 0 85301 1604
Crl:CD(SD) plasma creatinine level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 70 days 19 0.38 mg/dl 0.0 0.02 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85371 1604
Crl:CD(SD) urine taurine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 106 days 19 142.0 umol/d 12.64 55.1 liquid chromatography-mass spectrometry 0.0 0 85397 1604
Crl:CD(SD) urine taurine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 169 days 19 129.3 umol/d 8.3 36.2 liquid chromatography-mass spectrometry 0.0 0 85400 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 168 days 19 37.3 U/l 0.96 4.2 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85440 1604
Crl:CD(SD) plasma acetaminophen level area under curve standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 893.3 (ug/ml) x h 44.55 126.0 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 4-19 hr dosing 4-19 hr dosing 85587 1604
Crl:CD(SD) plasma acetaminophen level standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 1.1 ug/ml 0.32 0.9 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 19 hr after dosing 85583 1604
Crl:CD(SD) plasma acetaminophen level standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 64.3 ug/ml 9.72 27.5 high-performance liquid chromatography 0.0 acetaminophen dosing 240 min 4 hr after dosing 85581 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 168 days 19 52.7 U/l 1.26 5.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85424 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 8 18.7 g/d 1.45 4.1 unspecified method 0.0 0 85475 1604
Crl:CD(SD) plasma acetaminophen level area under curve standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 500.6 (ug/ml) x h 64.42 182.2 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 4-19 hr dosing 4-19 hr dosing 85589 1604
GK/Jcl heart left ventricle weight standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. heart left ventricle mass male 84 days 8 0.68 g 0.01 0.03 post excision weight measurement 0.0 0 103065 2785
Jcl:WI blood triglyceride level standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. blood triglyceride amount male 84 days 8 47.79 mg/dl 4.38 12.39 blood triglyceride analysis 0.0 0 103075 2785
SS mean arterial blood pressure standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. arterial blood pressure trait male 49 days 8 124.0 mmHg 2.12 6.0 tail cuff plethysmography 0.0 0 102266 2683
SR/Hsd body weight standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. body mass male 49 days 8 213.0 g 2.4 6.8 body weighing method 0.0 0 102271 2683
Jcl:WI blood total cholesterol level standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. blood cholesterol amount male 84 days 8 51.74 mg/dl 2.59 7.34 blood cholesterol analysis 0.0 0 103079 2785
WKY liver cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. liver cholesterol amount male 0 days 7 3.92 mg/g 0.24 0.63 enzymatic cholesterol assay 0.0 0 98894 2178
HTG blood very low density lipoprotein triglyceride level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood VLDL triglyceride amount male 0 days 7 1.84 mg/dl 0.36 0.95 enzymatic triglyceride assay 0.0 0 98924 2178
WI body weight controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. body mass male 68 days 35 303.6 g 6.5 38.45 body weighing method 0.0 0 101054 2563
WI serum potassium level controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood potassium amount male 102 days 6 3.67 mmol/l 0.21 0.51 automated serum potassium test 0.0 0 101060 2563
WI serum sodium level controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood sodium amount male 102 days 6 128.66 mmol/l 1.8 4.41 automated serum sodium test 0.0 0 101057 2563
SHR/N-cp both kidneys wet weight to body weight ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney mass male 140 days-168 days 8 1.83 g/kg 0.31 0.88 post excision weight measurement 0.0 0 101525 2601
SHR/N-cp plasma renin activity level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. renin activity male 168 days-196 days 8 11.0 ng/ml/h 2.0 5.66 radioimmunoassay 0.0 0 101532 2601
SHR/N-cp kidney sclerotic glomeruli count to total glomeruli count ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney glomerulus integrity trait male 140 days-168 days 8 4.0 % 1.0 2.83 ex vivo light microscopy with histochemistry 0.0 0 101528 2601
MHS artery inner diameter standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 14.5 um 0.47 1.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104227 2927
SD-Lepem1Sage-/- blood glucose level fasting (for 16 hours) then standard diet (for 1 hours) D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. blood glucose amount female 91 days 6 216.0 mg/dl 23.4 57.32 blood glucose test strip read by electrochemical glucometer 0.0 0 104473 2949
SD-Lepem1Sage+/+ blood insulin level fasting (for 12 hours) then standard diet (for 1 hours) D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. blood insulin amount male 91 days 6 16.18 mU/l 4.12 10.09 blood insulin analysis 0.0 0 104475 2949
SD-Lepem1Sage-/- blood insulin level fasting (for 12 hours) then standard diet (for 1 hours) D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. blood insulin amount female 91 days 6 4727.1 mU/l 1370.6 3357.27 blood insulin analysis 0.0 0 104481 2949
SD-Abcc6em2Qlju+/- serum calcium level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount female 60 days-180 days 5 10.1 mg/dl 0.2 0.45 colorimetry 0.0 0 104639 2972
SD-Abcc6em2Qlju+/+ serum phosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood phosphate amount male 60 days-180 days 5 7.0 mg/dl 0.3 0.67 liquid phase colorimetry 0.0 0 104642 2972
SD-Abcc6em2Qlju-/- serum calcium to serum phosphate ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount female 60 days-180 days 5 1.73 null 0.04 0.09 colorimetry 0.0 0 104653 2972
SD-Abcc6em2Qlju+/+ serum phosphate level to plasma pyrophosphate level ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount female 60 days-180 days 5 558.9 null 97.9 218.91 liquid phase colorimetry 0.0 0 104661 2972
MHS serum creatinine level standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. blood creatinine amount male 63 days 10 0.31 mg/dl 0.0 0.02 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104175 2927
Crl:WI creatinine clearance standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. glomerular filtration trait male 63 days 10 1.1 ml/min 0.01 0.04 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104182 2927
MNS creatinine clearance standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. glomerular filtration trait male 270 days 10 0.55 ml/min 0.03 0.1 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104183 2927
MHS urine total protein excretion rate standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. total urine protein amount male 63 days 10 19.03 mg/d 1.17 3.7 urine protein analysis 0.0 0 104187 2927
Crl:WI urine total protein excretion rate standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. total urine protein amount male 270 days 10 23.7 mg/d 1.57 4.96 urine protein analysis 0.0 0 104191 2927
Crl:WI creatinine clearance standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. glomerular filtration trait male 270 days 10 0.94 ml/min 0.02 0.05 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104185 2927
MHS left kidney wet weight to body weight ratio standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 270 days 10 2.1 mg/g 0.03 0.1 post excision weight measurement 0.0 0 104208 2927
MHS artery tunica media width to artery inner diameter ratio standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 0.83 null 0.02 0.07 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104215 2927
MHS artery diameter standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 35.1 um 0.7 2.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104213 2927
MNS artery tunica media width to artery inner diameter ratio standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 0.5 null 0.02 0.06 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104224 2927
MHS artery tunica media width to artery inner diameter ratio standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 0.65 null 0.01 0.02 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104225 2927
MNS artery lumen to artery total diameter ratio standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 49.8 % 2.28 7.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104230 2927
MNS artery lumen to artery total diameter ratio standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 48.7 % 0.95 3.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104232 2927
MHS artery lumen to artery total diameter ratio standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 40.2 % 0.32 1.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104231 2927
MWF/Ztm systolic blood pressure standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. arterial blood pressure trait male 252 days-253 days 5 170.0 mmHg 3.58 8.0 tail cuff plethysmography tail 0.0 0 109144 3136
MWF/Fub systolic blood pressure standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. arterial blood pressure trait male 100 days-103 days 8 165.0 mmHg 2.0 5.66 tail cuff plethysmography tail 0.0 0 109021 3134
MWF/Ztm mesangium volume per glomerulus standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. kidney glomerulus morphology trait male 131 days 6 Pc/Pr, number of grid points falling into the component (Pc: mesangial cells and matrix) and the number of points falling into the reference area (Pr. i.e., the glomerular tuft 0.14 x 10E-6 um3 0.02 0.04 ex vivo electron microscopy with digital image analysis renal glomerulus 0.0 0 mesangium volume per glomerulus (CMO:0003716) 109168 3136
MWF/Ztm podocyte foot process height standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. podocyte morphology trait male 131 days 6 378.0 nm 34.29 84.0 ex vivo electron microscopy with digital image analysis 0.0 0 109187 3136
MWF/Ztm podocyte slit width standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. podocyte morphology trait male 252 days-253 days 5 37.0 nm 0.89 2.0 ex vivo electron microscopy with digital image analysis 0.0 0 109191 3136
Crl:WI urine total protein excretion rate standard diet Remuzzi A, etal., Kidney Int. 1988 Oct;34(4):481-6. doi: 10.1038/ki.1988.206. urine protein amount both 147 days 12 28.0 mg/d 2.89 10.0 Bradford protein assay 0.0 0 109204 3138
MWF/Ztm urine total protein excretion rate standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. total urine protein amount male 140 days 10 165.0 mg/d 18.02 57.0 Bradford protein assay 0.0 0 109979 3162
MWF/Ztm right kidney wet weight standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. kidney mass male 210 days 10 1.39 g 0.03 0.09 post excision weight measurement right kidney 0.0 0 109983 3162
MWF/Ztm urine total protein excretion rate standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. total urine protein amount male 131 days 6 162.0 mg/d 4.9 12.0 Bradford protein assay 0.0 0 109146 3136
SHRSP/A3NCrl partial pressure of brain white matter oxygen sham surgical control condition then standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 84 days 8 41.8 mmHg 2.5 7.07 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds partial pressure of brain white matter oxygen (CMO:0003626) 107319 3080
SHRSP/A3NCrl partial pressure of brain white matter oxygen sham surgical control condition then standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 91 days 8 19.7 mmHg 3.4 9.62 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds partial pressure of brain white matter oxygen (CMO:0003626) 107320 3080
SHRSP/A3NCrl partial pressure of brain white matter oxygen sham surgical control condition then standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 112 days 8 15.4 mmHg 3.8 10.75 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds partial pressure of brain white matter oxygen (CMO:0003626) 107324 3080
SHRSP/A3NCrl partial pressure of brain white matter oxygen sham surgical control condition then standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 105 days 8 16.8 mmHg 3.7 10.47 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds partial pressure of brain white matter oxygen (CMO:0003626) 107323 3080
SHRSP/A3NCrl partial pressure of brain white matter oxygen standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 84 days 6 34.1 mmHg 2.7 6.61 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds vascular cognitive impairment 107314 3080
MWF/Fub systolic blood pressure standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. arterial blood pressure trait female 100 days-103 days 8 156.0 mmHg 3.0 8.49 tail cuff plethysmography tail 0.0 0 109020 3134
SD-Ldlrem1Sage plasma albumin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood albumin amount male 448 days 8 0.35 g/l 0.01 0.03 automated plasma albumin analysis 0.0 0 138277 3201
Hsd:SD plasma total protein level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood total protein amount male 448 days 9 65.2 mg/ml 2.0 6.0 automated plasma total protein analysis 0.0 0 138280 3201
Hsd:SD plasma aspartate aminotransferase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood aspartate transaminase amount male 448 days 9 159.0 U/l 16.0 48.0 automated plasma aspartate aminotransferase activity assay 0.0 0 138289 3201
Hsd:SD blood very low density lipoprotein particle diameter standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood VLDL particle size male 448 days 9 38.0 nm 1.5 4.5 nuclear magnetic resonance spectroscopy 0.0 0 138330 3201
SD-Ldlrem1Sage blood interleukin-4 level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood interleukin-4 amount male 448 days 8 11.0 pg/ml 2.0 5.66 enzyme linked immunosorbent assay 0.0 0 138361 3201
SD-Ldlrem1Sage blood low density lipoprotein particle diameter standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood LDL particle size male 448 days 8 22.9 nm 0.1 0.28 nuclear magnetic resonance spectroscopy 0.0 0 138335 3201
SD-Ldlrem1Sage blood high density lipoprotein particle diameter standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood HDL particle size male 448 days 8 13.0 nm 0.1 0.28 nuclear magnetic resonance spectroscopy 0.0 0 138339 3201
Hsd:SD plasma plasminogen activator inhibitor 1 level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood plasminogen activator inhibitor 1 amount male 448 days 9 9.31 ng/ml 0.79 2.37 enzyme linked immunosorbent assay 0.0 0 138306 3201
SD-Ldlrem1Sage blood fibrinogen level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. fibrin formation trait male 448 days 8 2.87 mg/ml 0.17 0.47 enzyme linked immunosorbent assay 0.0 0 138311 3201
Hsd:SD plasma free fatty acids level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood free fatty acid amount male 448 days 9 0.52 mmol/l 0.04 0.12 plasma free fatty acid analysis 0.0 0 138322 3201
Hsd:SD plasma chylomicron and VLDL cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 9 10.0 mg/dl 1.0 3.0 blood cholesterol analysis 0.0 0 138460 3201
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 78 days 19 35.0 U/l 1.49 6.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85429 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 19 17.2 g/d 0.6 2.6 unspecified method 0.0 0 85293 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 8 4.09 g/d/100g 0.45 1.28 unspecified method 0.0 0 on days 74-77 85507 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 8 4.53 g/d/100g 0.13 0.36 unspecified method 0.0 0 on days 53-56 85502 1604
WI body weight controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. body mass male 1 days 21 8.4 g 0.8 3.67 body weighing method 0.0 0 101051 2563
SD-Abcc6em2Qlju+/+ serum calcium to serum phosphate ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount female 60 days-180 days 5 1.61 null 0.06 0.13 colorimetry 0.0 0 104649 2972
SD-Abcc6em2Qlju-/- serum phosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood phosphate amount male 60 days-180 days 5 7.1 mg/dl 0.5 1.12 liquid phase colorimetry 0.0 0 104646 2972
MNS timed urine volume standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. urine output male 63 days 10 14.2 ml/d 1.66 5.26 urine volume measurement method 0.0 0 104168 2927
MHS body weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. body mass male 63 days 10 245.4 g 3.98 12.6 body weighing method 0.0 0 104193 2927
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 78 days 19 0.41 mg/dl 0.03 0.11 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85340 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 105 days 19 129.0 mg/dl 1.38 6.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85328 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 91 days 19 25.2 mg/dl 2.09 9.1 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85359 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 105 days 19 0.81 mg/dl 0.06 0.27 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85345 1604
Crl:CD(SD) urine creatine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 134 days 19 2.0 umol/d 0.13 0.57 liquid chromatography-mass spectrometry 0.0 0 85383 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 147 days 19 55.4 U/l 2.25 9.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85422 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 168 days 19 33.2 U/l 1.1 4.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85441 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 168 days 19 12.8 U/l 0.69 3.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85457 1604
WKY plasma very low density lipoprotein cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood VLDL cholesterol amount male 0 days 7 2.7 mg/dl 0.39 1.02 enzymatic cholesterol assay 0.0 0 98906 2178
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 8 24.5 g/d 0.57 1.6 unspecified method 0.0 0 85465 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 8 24.5 g/d 0.32 0.9 unspecified method 0.0 0 85478 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 19 19.4 g/d 0.87 3.8 unspecified method 0.0 0 85297 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168 days 19 444.0 g 6.65 29.0 body weighing method 0.0 0 85321 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 78 days 19 0.69 mg/dl 0.15 0.64 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85341 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126 days 19 401.0 g 4.82 21.0 body weighing method 0.0 0 85317 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 119 days 19 19.8 mg/dl 0.87 3.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85362 1604
Crl:CD(SD) urine creatinine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 169 days 19 14.95 mg/d 0.54 2.38 liquid chromatography-mass spectrometry 0.0 0 85392 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 19 0.21 umol/g 0.01 0.03 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method oxidized liver glutathione level to liver weight ratio 85408 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 78 days 19 17.9 U/l 1.61 7.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85445 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 8 23.4 g/d 0.42 1.2 unspecified method 0.0 0 85483 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 8 18.2 g/d 1.13 3.2 unspecified method 0.0 0 85468 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 8 22.8 g/d 0.71 2.0 unspecified method 0.0 0 85484 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 8 4.05 g/d/100g 0.08 0.24 unspecified method 0.0 0 on days 95-98 85513 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126 days 8 516.0 g 12.73 36.0 body weighing method 0.0 0 85538 1604
Crl:CD(SD) plasma acetaminophen level area under curve standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 662.2 (ug/ml) x h 28.35 80.2 high-performance liquid chromatography 0.0 acetaminophen dosing 1140 min 4-19 hr dosing 4-19 hr dosing 85586 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 8 5.19 umol/g 0.24 0.69 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method 85571 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 119 days 19 0.61 mg/dl 0.02 0.08 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85346 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 168 days 19 128.0 mg/dl 1.84 8.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85337 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 19 4.18 g/d/100g 0.19 0.84 unspecified method 0.0 0 85307 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 91 days 19 1.0 mg/dl 0.08 0.35 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85343 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 105 days 19 0.49 mg/dl 0.02 0.1 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85344 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 147 days 19 0.47 mg/dl 0.05 0.21 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85350 1604
Crl:CD(SD) plasma creatinine level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 133 days 19 0.41 mg/dl 0.01 0.04 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85375 1604
Crl:CD(SD) urine taurine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine taurine amount male 134 days 19 141.5 umol/d 12.76 55.6 liquid chromatography-mass spectrometry 0.0 0 85398 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 91 days 19 56.3 U/l 1.12 4.9 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85414 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 133 days 19 57.6 U/l 1.58 6.9 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85421 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 78 days 19 33.9 U/l 0.83 3.6 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85428 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 8 24.3 g/d 0.32 0.9 unspecified method 0.0 0 85477 1604
Crl:CD(SD) liver wet weight standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170 days 8 12.2 g 0.77 2.17 unspecified method 0.0 0 85558 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 70 days 19 35.3 U/l 1.03 4.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85427 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 147 days 19 54.3 U/l 1.26 5.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85423 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 8 0.24 umol/g 0.01 0.02 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85573 1604
Jcl:WI body weight standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. body mass male 84 days 8 432.0 g 10.25 29.0 body weighing method 0.0 0 103055 2785
GK/Jcl body weight standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. body mass male 84 days 8 353.0 g 7.07 20.0 body weighing method 0.0 0 103057 2785
GK/Jcl heart weight standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. heart mass male 84 days 8 0.98 g 0.01 0.04 post excision weight measurement 0.0 0 103061 2785
Jcl:WI heart left ventricle weight standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. heart left ventricle mass male 84 days 8 0.81 g 0.03 0.08 post excision weight measurement 0.0 0 103063 2785
GK/Jcl blood triglyceride level standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. blood triglyceride amount male 84 days 8 107.08 mg/dl 9.07 25.66 blood triglyceride analysis 0.0 0 103077 2785
HTG liver triglyceride level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. liver triglyceride amount male 0 days 7 10.17 mg/g 1.14 3.02 enzymatic triglyceride assay 0.0 0 98900 2178
SR/Hsd creatinine clearance standard diet Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19. glomerular filtration trait male 49 days 8 3.5 ml/min 0.07 0.2 urine creatinine analysis 0.0 0 102287 2683
WI body weight controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. body mass male 1 days 35 4.7 g 0.07 0.41 body weighing method 0.0 0 101052 2563
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 84 and 98 days) then perindopril (0.25-0.5 mg/kg/d) (between 28 and 42 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 112 days-140 days 8 192.39 mg/dl 29.04 82.14 serum glucose analysis 0.0 0 101503 2601
SHR/N-cp kidney sclerotic glomeruli count to total glomeruli count ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney glomerulus integrity trait male 168 days-196 days 8 9.0 % 4.0 11.31 ex vivo light microscopy with histochemistry 0.0 0 101527 2601
WI creatinine clearance to body weight ratio controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. glomerular filtration trait male 102 days 6 0.48 ml/min/100g 0.08 0.18 serum creatinine analysis 0.0 0 101066 2563
WI serum urea nitrogen level controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood urea nitrogen amount male 102 days 6 45.33 mg/dl 4.7 11.51 serum urea nitrogen analysis 0.0 0 101068 2563
WI glucose disappearance constant controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood glucose amount male 102 days 6 2.88 null 0.3 0.73 serum glucose analysis 0.0 0 101074 2563
WI plasma total cholesterol level controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood cholesterol amount male 102 days 6 42.0 mg/dl 3.87 9.48 plasma total cholesterol measurement test 0.0 0 101072 2563
MHS artery tunica media width to artery inner diameter ratio standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 0.89 null 0.03 0.09 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104217 2927
SD-Lepem1Sage+/+ blood glucose level fasting (for 16 hours) then standard diet (for 1 hours) D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. blood glucose amount female 91 days 6 142.56 mg/dl 12.42 30.42 blood glucose test strip read by electrochemical glucometer 0.0 0 104472 2949
SD-Lepem1Sage-/- blood glucose level fasting (for 16 hours) then standard diet (for 1 hours) D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. blood glucose amount male 91 days 6 185.76 mg/dl 16.74 41.0 blood glucose test strip read by electrochemical glucometer 0.0 0 104471 2949
SD-Lepem1Sage+/+ blood insulin level fasting (for 12 hours) then standard diet (for 1 hours) D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. blood insulin amount female 91 days 6 17.35 mU/l 3.82 9.37 blood insulin analysis 0.0 0 104479 2949
SD-Abcc6em2Qlju-/- serum calcium level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount female 60 days-180 days 5 10.2 mg/dl 0.3 0.67 colorimetry 0.0 0 104641 2972
SD-Abcc6em2Qlju+/+ serum calcium level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount male 60 days-180 days 5 10.8 mg/dl 0.4 0.89 colorimetry 0.0 0 104636 2972
MNS creatinine clearance standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. glomerular filtration trait male 63 days 10 1.09 ml/min 0.01 0.03 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104180 2927
Crl:WI left kidney wet weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 63 days 10 0.99 g 0.02 0.06 post excision weight measurement 0.0 0 104200 2927
Crl:WI left kidney wet weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 270 days 10 1.57 g 0.07 0.22 post excision weight measurement 0.0 0 104203 2927
MHS left kidney wet weight to body weight ratio standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 63 days 10 3.1 mg/g 0.03 0.1 post excision weight measurement 0.0 0 104205 2927
MNS artery diameter standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 35.9 um 1.33 4.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104212 2927
MNS artery tunica media width to artery inner diameter ratio standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 0.5 null 0.02 0.07 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104222 2927
MWF/Ztm systolic blood pressure standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. arterial blood pressure trait male 131 days 6 151.0 mmHg 2.86 7.0 tail cuff plethysmography tail 0.0 0 109143 3136
MWF/Ztm body weight standard diet Remuzzi A, etal., Kidney Int. 1988 Oct;34(4):481-6. doi: 10.1038/ki.1988.206. body mass male 105 days-147 days 8 317.0 g 18.74 53.0 body weighing method 0.0 0 109197 3138
MWF/Ztm total pericapillary slit length standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. podocyte morphology trait male 131 days 6 647.43 mm 33.65 82.42 ex vivo electron microscopy with digital image analysis 0.0 0 109179 3136
MWF/Ztm mean length density of glomerular capillaries standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. glomerular capillary morphology trait male 131 days 6 2xNcap/k2xPr, Ncap is number of capillary profiles, k2 is ratio between the distance (In micrometers) of two adjacent grid points and the magnification, Pr is grid points falling Into the glomerular tuft 11.8 REQUEST NEW VALUE 0.53 1.3 ex vivo electron microscopy with digital image analysis renal glomerulus 0.0 0 109175 3136
MWF/Ztm podocyte foot process width standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. podocyte morphology trait male 252 days-253 days 5 219.0 nm 6.71 15.0 ex vivo electron microscopy with digital image analysis 0.0 0 109192 3136
MWF/Ztm podocyte foot process height standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. podocyte morphology trait male 252 days-253 days 5 306.0 nm 11.63 26.0 ex vivo electron microscopy with digital image analysis 0.0 0 109193 3136
MWF/Ztm body weight standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. body mass male 210 days 10 423.0 g 5.38 17.0 body weighing method 0.0 0 109975 3162
LEW/Mol kidney weight standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. kidney mass female 104 days 8 0.72 g 0.01 0.03 post excision weight measurement kidney 0.0 0 109004 3134
Crl:WI urine total protein excretion rate standard diet Remuzzi A, etal., Kidney Int. 1988 Oct;34(4):481-6. doi: 10.1038/ki.1988.206. urine protein amount both 49 days 12 10.0 mg/d 0.87 3.0 Bradford protein assay 0.0 0 109203 3138
MWF/Ztm urine total protein excretion rate standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. total urine protein amount male 140 days 7 172.0 mg/d 29.86 79.0 Bradford protein assay 0.0 0 109980 3162
MWF/Ztm kidney sclerotic glomeruli count to total glomeruli count ratio standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. kidney glomerulus integrity trait male 140 days 8 median 2.2 % ex vivo light microscopy with histochemistry left kidney 0.0 0 109985 3162
MWF/Ztm urine total protein excretion rate standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. total urine protein amount male 252 days-253 days 5 309.0 mg/d 26.83 60.0 Bradford protein assay 0.0 0 109147 3136
SHRSP/A3NCrl partial pressure of brain white matter oxygen sham surgical control condition then standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 98 days 8 18.0 mmHg 3.4 9.62 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds partial pressure of brain white matter oxygen (CMO:0003626) 107322 3080
LEW/Mol kidney weight standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. kidney mass male 104 days 8 1.1 g 0.03 0.08 post excision weight measurement kidney 0.0 0 109005 3134
LEW/Mol kidney wet weight to body weight ratio standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. kidney mass male 104 days 8 4.04 mg/g 0.03 0.08 post excision weight measurement kidney 0.0 0 109013 3134
SHRSP/A3NCrl partial pressure of brain white matter oxygen standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 98 days 6 26.0 mmHg 1.2 2.94 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds vascular cognitive impairment 107316 3080
LEW/Mol body weight standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. body mass male 104 days 8 280.0 g 8.5 24.04 body weighing method 0.0 0 108997 3134
AA liver cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. liver cholesterol amount male 448 days 8 10.38 mg/g 2.17 6.14 isolated tissue cholesterol measurement test 0.0 0 138343 3201
Hsd:SD liver triglyceride level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. liver triglyceride amount male 448 days 9 13.12 mg/g 1.35 4.05 isolated tissue triglyceride measurement test 0.0 0 138346 3201
SD-Ldlrem1Sage plasma interleukin-6 level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood interleukin-6 amount male 448 days 10 140.0 pg/ml 56.0 177.09 enzyme linked immunosorbent assay 0.0 0 138351 3201
Hsd:SD blood low density lipoprotein particle diameter standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood LDL particle size male 448 days 9 22.7 nm 0.1 0.3 nuclear magnetic resonance spectroscopy 0.0 0 138334 3201
SD-Ldlrem1 plasma creatinine level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood creatinine amount male 448 days 8 0.53 mg/dl 0.04 0.11 automated plasma creatinine analysis 0.0 0 138299 3201
SD-Ldlrem1Sage blood urea nitrogen level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood urea nitrogen amount male 448 days 8 14.0 mg/dl 1.0 2.83 automated blood urea nitrogen analysis 0.0 0 138303 3201
SD-Ldlrem1Sage plasma plasminogen activator inhibitor 1 level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood plasminogen activator inhibitor 1 amount male 448 days 8 10.36 ng/ml 0.49 1.39 enzyme linked immunosorbent assay 0.0 0 138307 3201
Hsd:SD plasma leptin level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood leptin amount male 448 days 9 9.83 ng/ml 0.68 2.04 enzyme linked immunosorbent assay 0.0 0 138314 3201
SD-Ldlrem1Sage plasma free fatty acids level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood free fatty acid amount male 448 days 8 0.78 mmol/l 0.12 0.34 plasma free fatty acid analysis 0.0 0 138323 3201
Hsd:SD plasma high density lipoprotein cholesterol level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood cholesterol amount male 448 days 9 69.0 mg/dl 11.0 33.0 blood cholesterol analysis 0.0 0 138326 3201
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 19 23.7 g/d 0.48 2.1 unspecified method 0.0 0 85298 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 19 5.28 g/d/100g 0.06 0.24 unspecified method 0.0 0 85302 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147 days 19 430.0 g 5.96 26.0 body weighing method 0.0 0 85319 1604
Crl:CD(SD) body weight standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126 days 19 526.0 g 13.31 58.0 body weighing method 0.0 0 85316 1604
Crl:CD(SD) urine creatine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatine amount male 106 days 19 1.71 umol/d 0.09 0.39 liquid chromatography-mass spectrometry 0.0 0 85381 1604
Crl:CD(SD) urine creatinine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 134 days 19 16.46 mg/d 0.22 0.97 liquid chromatography-mass spectrometry 0.0 0 85390 1604
Crl:CD(SD) urine creatinine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 169 days 19 12.28 mg/d 0.58 2.51 liquid chromatography-mass spectrometry 0.0 0 85393 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84 days 8 333.0 g 8.13 23.0 body weighing method 0.0 0 85528 1604
Crl:CD(SD) liver wet weight standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver mass male 170 days 8 12.8 g 0.22 0.61 unspecified method 0.0 0 85559 1604
WI body weight controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. body mass male 68 days 21 284.6 g 11.24 51.51 body weighing method 0.0 0 101053 2563
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 140 days-168 days 8 139.76 mg/dl 29.04 82.14 serum glucose analysis 0.0 0 101510 2601
SD-Abcc6em2Qlju-/- serum calcium to serum phosphate ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount male 60 days-180 days 5 1.53 null 0.12 0.27 colorimetry 0.0 0 104652 2972
SD-Abcc6em2Qlju+/+ plasma pyrophosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount male 60 days-180 days 5 1.08 umol/l 0.17 0.38 enzymatic method 0.0 0 104654 2972
SD-Abcc6em2Qlju-/- serum phosphate level to plasma pyrophosphate level ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount female 60 days-180 days 5 1925.5 null 479.2 1071.52 liquid phase colorimetry 0.0 0 104665 2972
SD-Abcc6em2Qlju+/- serum phosphate level to plasma pyrophosphate level ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount female 60 days-180 days 5 710.9 null 48.5 108.45 liquid phase colorimetry 0.0 0 104663 2972
Crl:WI urine total protein excretion rate standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. total urine protein amount male 63 days 10 22.8 mg/d 2.47 7.81 urine protein analysis 0.0 0 104188 2927
MHS creatinine clearance standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. glomerular filtration trait male 63 days 10 1.09 ml/min 0.02 0.05 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104181 2927
MNS left kidney wet weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 63 days 10 1.05 g 0.02 0.07 post excision weight measurement 0.0 0 104198 2927
MNS artery tunica media width to artery inner diameter ratio standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 0.55 null 0.06 0.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104214 2927
MHS artery tunica media width to artery inner diameter ratio standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 0.6 null 0.0 0.01 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104223 2927
MNS artery tunica media width to artery inner diameter ratio standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 0.54 null 0.04 0.13 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104216 2927
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71 days 19 288.0 g 3.67 16.0 body weighing method 0.0 0 85311 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 91 days 19 135.0 mg/dl 1.15 5.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85326 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 133 days 19 124.0 mg/dl 1.61 7.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85333 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 91 days 19 0.62 mg/dl 0.01 0.05 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85342 1604
Crl:CD(SD) plasma creatinine level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 70 days 19 0.41 mg/dl 0.0 0.02 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85370 1604
Crl:CD(SD) plasma acetaminophen level standard diet then acetaminophen (500 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood acetaminophen amount male 170 days 8 118.1 ug/ml 6.43 18.2 high-performance liquid chromatography 0.0 acetaminophen dosing 240 min 4 hr after dosing 85579 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 105 days 19 14.7 U/l 0.64 2.8 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85448 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 8 25.7 g/d 0.28 0.8 unspecified method 0.0 0 85466 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 8 16.6 g/d 0.95 2.7 unspecified method 0.0 0 85487 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168 days 8 447.0 g 16.62 47.0 body weighing method 0.0 0 85552 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 19 20.1 g/d 0.5 2.2 unspecified method 0.0 0 85295 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 168 days 19 17.2 g/d 0.83 3.6 unspecified method 0.0 0 85299 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 105 days 19 5.36 g/d/100g 0.15 0.65 unspecified method 0.0 0 85303 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 19 4.44 g/d/100g 0.06 0.28 unspecified method 0.0 0 85306 1604
Crl:CD(SD) plasma creatinine level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 105 days 19 0.41 mg/dl 0.01 0.03 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85373 1604
Crl:CD(SD) urine creatinine excretion rate standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 106 days 19 11.98 mg/d 0.42 1.84 liquid chromatography-mass spectrometry 0.0 0 85389 1604
Crl:CD(SD) urine creatinine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 106 days 19 13.78 mg/d 0.28 1.21 liquid chromatography-mass spectrometry 0.0 0 85388 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 78 days 19 61.0 U/l 2.09 9.1 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85412 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 78 days 19 59.1 U/l 1.28 5.6 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85413 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 70 days 19 61.8 U/l 1.26 5.5 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85411 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 105 days 19 58.0 U/l 2.39 10.4 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85416 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 70 days 19 32.5 U/l 0.71 3.1 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85426 1604
Crl:CD(SD) food intake rate standard diet then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 8 24.7 g/d 0.46 1.3 unspecified method 0.0 0 85460 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 84 days 8 5.74 g/d/100g 0.1 0.29 unspecified method 0.0 0 on days 11-14 85489 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 8 4.7 g/d/100g 0.06 0.17 unspecified method 0.0 0 on days 53-56 85501 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 8 4.38 g/d/100g 0.31 0.87 unspecified method 0.0 0 on days 53-56 85504 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet then acetaminophen (500 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 8 4.49 g/d/100g 0.08 0.23 unspecified method 0.0 0 on days 74-77 85508 1604
Crl:CD(SD) food intake weight to body weight ratio standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 8 4.23 g/d/100g 0.27 0.77 unspecified method 0.0 0 on days 53-56 85505 1604
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 1 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 71 days 8 371.0 g 5.66 16.0 body weighing method 0.0 0 85519 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 126 days 8 400.0 g 7.78 22.0 body weighing method 0.0 0 85541 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 14 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84 days 8 321.0 g 7.78 22.0 body weighing method 0.0 0 85529 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (500 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105 days 8 365.0 g 6.36 18.0 body weighing method 0.0 0 85535 1604
Crl:CD(SD) body weight standard diet then acetaminophen (500 mg/kg) (for 98 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 168 days 8 564.0 g 15.2 43.0 body weighing method 0.0 0 85550 1604
Crl:CD(SD) plasma pyruvate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 133 days 19 0.91 mg/dl 0.1 0.43 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85349 1604
Crl:CD(SD) plasma pyruvate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood pyruvate amount male 133 days 19 0.55 mg/dl 0.03 0.12 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85348 1604
Crl:CD(SD) food intake rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 147 days 19 23.9 g/d 0.39 1.7 unspecified method 0.0 0 85296 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 84 days 19 328.0 g 4.82 21.0 body weighing method 0.0 0 85313 1604
Crl:CD(SD) plasma glucose level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 70 days 19 117.0 mg/dl 1.84 8.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85323 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 119 days 19 129.0 mg/dl 2.29 10.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85330 1604
Crl:CD(SD) plasma glucose level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glucose amount male 168 days 19 131.0 mg/dl 1.61 7.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85336 1604
Crl:CD(SD) plasma lactate level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 168 days 19 18.9 mg/dl 1.67 7.3 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85369 1604
Crl:CD(SD) plasma aspartate aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood aspartate transaminase amount male 119 days 19 58.8 U/l 1.54 6.7 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85419 1604
Crl:CD(SD) plasma alanine aminotransferase activity level standard diet and restricted feeding (4 h) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood alanine transaminase amount male 147 days 19 34.4 U/l 1.31 5.7 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85439 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 70 days 19 14.3 U/l 0.55 2.4 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85442 1604
Crl:CD(SD) plasma glutamate dehydrogenase activity level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood glutamate dehydrogenase amount male 119 days 19 14.8 U/l 0.89 3.9 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85450 1604
Crl:CD(SD) liver reduced glutathione level to liver weight ratio standard diet then acetaminophen (300 mg/kg) (for 99 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 8 9.16 umol/g 0.18 0.5 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method reduced liver glutathione level to liver weight ratio 85567 1604
Crl:CD(SD) food intake rate standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 56 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. eating behavior trait male 126 days 8 22.1 g/d 0.71 2.0 unspecified method 0.0 0 85474 1604
Crl:CD(SD) body weight standard diet and restricted feeding (4 h) then acetaminophen (300 mg/kg) (for 77 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 147 days 8 432.0 g 17.32 49.0 body weighing method 0.0 0 85546 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (500 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 8 0.14 umol/g 0.0 0.01 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method 85577 1604
GK/Jcl blood glucose level standard diet Radosinska J, et al., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8. blood glucose amount male 84 days 8 478.26 mg/dl 23.74 67.14 blood glucose analysis 0.0 0 103073 2785
HTG liver cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. liver cholesterol amount male 0 days 7 3.71 mg/g 0.13 0.35 enzymatic cholesterol assay 0.0 0 98896 2178
WKY plasma total cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood cholesterol amount male 0 days 7 61.39 mg/dl 4.25 11.24 enzymatic cholesterol assay 0.0 0 98902 2178
WKY plasma triglyceride level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood triglyceride amount male 0 days 7 0.48 mmol/l 0.02 0.05 enzymatic triglyceride assay 0.0 0 98918 2178
HTG plasma triglyceride level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood triglyceride amount male 0 days 7 0.83 mmol/l 0.07 0.19 enzymatic triglyceride assay 0.0 0 98920 2178
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 42 and 56 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 70 days-98 days 8 185.13 mg/dl 32.67 92.4 serum glucose analysis 0.0 0 101499 2601
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 42 and 56 days) then perindopril (0.25-0.5 mg/kg/d) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 70 days-98 days 8 154.28 mg/dl 19.97 56.47 serum glucose analysis 0.0 0 101500 2601
WI serum potassium level controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood potassium amount male 102 days 6 3.5 mmol/l 0.23 0.56 automated serum potassium test 0.0 0 101059 2563
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 42 and 56 days) then controlled hydralazine content drinking water (30 mg/l) and hydralazine (50 mg/l) and reserpine (4 mg/l) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 70 days-98 days 8 139.76 mg/dl 14.52 41.07 serum glucose analysis 0.0 0 101501 2601
SHR/N-cp both kidneys wet weight to body weight ratio standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. kidney mass male 168 days-196 days 8 1.88 g/kg 0.1 0.28 post excision weight measurement 0.0 0 101523 2601
SHR/N-cp plasma renin activity level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. renin activity male 168 days-196 days 8 52.0 ng/ml/h 8.0 22.63 radioimmunoassay 0.0 0 101533 2601
WI creatinine clearance to body weight ratio controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. glomerular filtration trait male 102 days 6 0.54 ml/min/100g 0.06 0.13 serum creatinine analysis 0.0 0 101065 2563
WI urine potassium excretion rate controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. urine potassium amount male 102 days 6 83.0 mEq/d 0.5 1.22 urine potassium analysis 0.0 0 101063 2563
SD-Lepem1Sage-/- blood insulin level fasting (for 12 hours) then standard diet (for 1 hours) D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. blood insulin amount male 91 days 6 2198.55 mU/l 95.59 234.14 blood insulin analysis 0.0 0 104477 2949
SD-Abcc6em2Qlju+/- serum calcium level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount male 60 days-180 days 5 10.0 mg/dl 0.3 0.67 colorimetry 0.0 0 104638 2972
SD-Abcc6em2Qlju+/- serum phosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood phosphate amount male 60 days-180 days 5 7.1 mg/dl 0.6 1.34 liquid phase colorimetry 0.0 0 104644 2972
SD-Abcc6em2Qlju-/- serum phosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood phosphate amount female 60 days-180 days 5 5.9 mg/dl 0.2 0.45 liquid phase colorimetry 0.0 0 104647 2972
SD-Abcc6em2Qlju+/- serum calcium to serum phosphate ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount female 60 days-180 days 5 1.76 null 0.05 0.11 colorimetry 0.0 0 104651 2972
SD-Abcc6em2Qlju-/- plasma pyrophosphate level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount male 60 days-180 days 5 0.29 umol/l 0.07 0.16 enzymatic method 0.0 0 104658 2972
MNS serum creatinine level standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. blood creatinine amount male 270 days 10 0.52 mg/dl 0.01 0.02 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104177 2927
MNS urine total protein excretion rate standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. total urine protein amount male 63 days 10 25.04 mg/d 1.77 5.6 urine protein analysis 0.0 0 104186 2927
MNS body weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. body mass male 270 days 10 565.2 g 8.06 25.5 body weighing method 0.0 0 104195 2927
MNS left kidney wet weight to body weight ratio standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 270 days 10 3.9 mg/g 0.03 0.1 post excision weight measurement 0.0 0 104207 2927
MNS artery inner diameter standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 18.1 um 1.08 3.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104228 2927
MHS artery lumen to artery total diameter ratio standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 36.7 % 0.6 1.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104233 2927
MWF/Ztm urine total protein excretion rate standard diet Remuzzi A, etal., Kidney Int. 1988 Oct;34(4):481-6. doi: 10.1038/ki.1988.206. urine protein amount male 147 days 5 291.0 mg/d 22.81 51.0 Bradford protein assay 0.0 0 109201 3138
MWF/Ztm podocyte slit width standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. podocyte morphology trait male 131 days 6 39.0 nm 1.63 4.0 ex vivo electron microscopy with digital image analysis 0.0 0 109185 3136
MWF/Ztm total filtering surface area per glomerulus standard diet Iordache BE, etal., J Am Soc Nephrol. 1994 Dec;5(6):1378-84. kidney glomerulus morphology trait male 131 days 6 NA 0.28 mm2 0.02 0.04 ex vivo electron microscopy with digital image analysis renal glomerulus 0.0 0 109163 3136
MWF/Ztm body weight standard diet Remuzzi A, etal., Kidney Int. 1988 Oct;34(4):481-6. doi: 10.1038/ki.1988.206. body mass female 126 days-153 days 8 218.0 g 3.89 11.0 body weighing method 0.0 0 109198 3138
MWF/Ztm kidney sclerotic glomeruli count to total glomeruli count ratio standard diet Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. kidney glomerulus integrity trait male 210 days 10 median 18.6 % ex vivo light microscopy with histochemistry left kidney 0.0 0 109986 3162
MWF/Fub kidney weight standard diet Kreutz R, etal., J Hypertens. 2000 Jun;18(6):777-82. doi: 10.1097/00004872-200018060-00017. kidney mass female 104 days 8 0.54 g 0.03 0.08 post excision weight measurement kidney 0.0 0 109008 3134
SHRSP/A3NCrl partial pressure of brain white matter oxygen standard diet Weaver J, etal., J Cereb Blood Flow Metab. 2014 May;34(5):890-6. doi: 10.1038/jcbfm.2014.35. Epub 2014 Feb 19. brain oxygen amount male 105 days 6 25.8 mmHg 1.2 2.94 electron paramagnetic resonance oximetry white matter 40.0 0 5 scans x 40 seconds vascular cognitive impairment 107317 3080
SD-Ldlrem1Sage plasma total protein level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood total protein amount male 448 days 8 68.2 mg/ml 2.5 7.07 automated plasma total protein analysis 0.0 0 138283 3201
SD-Ldlrem1Sage plasma alanine aminotransferase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood alanine transaminase amount male 448 days 8 39.0 U/l 1.0 2.83 automated plasma alanine aminotransferase activity assay 0.0 0 138286 3201
Hsd:SD plasma creatine kinase activity level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood creatine kinase amount male 448 days 9 670.0 U/l 93.0 279.0 automated plasma creatine kinase activity assay 0.0 0 CK 138293 3201
Hsd:SD blood urea nitrogen level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. blood urea nitrogen amount male 448 days 9 21.0 mg/dl 2.0 6.0 automated blood urea nitrogen analysis 0.0 0 138302 3201
Hsd:SD blood fibrinogen level standard diet Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. fibrin formation trait male 448 days 9 3.14 mg/ml 0.13 0.39 enzyme linked immunosorbent assay 0.0 0 138310 3201
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 133 days 19 17.4 mg/dl 0.85 3.7 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85364 1604
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 70 days 19 20.5 mg/dl 1.81 7.9 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85354 1604
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 84 and 98 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 112 days-140 days 8 150.65 mg/dl 23.6 66.74 serum glucose analysis 0.0 0 101502 2601
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 112 and 126 days) then controlled hydralazine content drinking water (30 mg/l) (between 56 and 70 days) and hydralazine (50 mg/l) (between 56 and 70 days) and reserpine (4 mg/l) (between 56 and 70 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 140 days-168 days 8 157.91 mg/dl 34.49 97.54 serum glucose analysis 0.0 0 101507 2601
SHR/N-cp serum glucose level standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 84 and 98 days) then controlled hydralazine content drinking water (30 mg/l) (between 28 and 42 days) and hydralazine (50 mg/l) (between 28 and 42 days) and reserpine (4 mg/l) (between 28 and 42 days) Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. blood glucose amount male 112 days-140 days 8 137.94 mg/dl 30.86 87.27 serum glucose analysis 0.0 0 101504 2601
WI plasma triglyceride level controlled in utero environment (for 21 days) and standard diet (50 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood triglyceride amount male 102 days 6 0.52 mmol/l 0.05 0.13 plasma triglyceride analysis 0.0 0 101070 2563
WI glucose disappearance constant controlled in utero environment (for 21 days) and standard diet (100 % of calories) (for 21 days) Ceravolo GS, et al., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. blood glucose amount male 102 days 6 2.86 null 0.35 0.86 serum glucose analysis 0.0 0 101073 2563
Crl:CD(SD) body weight standard diet then acetaminophen (300 mg/kg) (for 35 days) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. body mass male 105 days 8 477.0 g 7.42 21.0 body weighing method 0.0 0 85531 1604
Crl:CD(SD) liver oxidized glutathione level to liver weight ratio standard diet and restricted feeding (4 h) (for 114 days) then acetaminophen (300 mg/kg) (for 99 days) then fasting (for 20 hours) Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. liver glutathione amount male 170 days 8 0.16 umol/g 0.01 0.03 reduced glutathione/oxidized glutathione enzyme recycling assay 0.0 0 enzyme recycling method 85576 1604
SD-Abcc6em2Qlju+/+ serum calcium level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount female 60 days-180 days 5 9.7 mg/dl 0.2 0.45 colorimetry 0.0 0 104637 2972
SD-Abcc6em2Qlju-/- serum calcium level standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood calcium amount male 60 days-180 days 5 10.5 mg/dl 0.2 0.45 colorimetry 0.0 0 104640 2972
SD-Abcc6em2Qlju+/+ serum phosphate level to plasma pyrophosphate level ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount male 60 days-180 days 5 455.3 null 54.2 121.19 liquid phase colorimetry 0.0 0 104660 2972
Crl:WI timed urine volume standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. urine output male 63 days 10 15.6 ml/d 2.25 7.13 urine volume measurement method 0.0 0 104173 2927
Crl:WI serum creatinine level standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. blood creatinine amount male 63 days 10 0.32 mg/dl 0.0 0.01 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104176 2927
MHS serum creatinine level standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. blood creatinine amount male 270 days 10 0.38 mg/dl 0.01 0.02 creatinine analysis by Jaffe reaction with spectrophotometric readout 0.0 0 104178 2927
MNS left kidney wet weight standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 270 days 10 2.18 g 0.04 0.13 post excision weight measurement 0.0 0 104201 2927
MNS left kidney wet weight to body weight ratio standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 63 days 10 3.9 mg/g 0.06 0.2 post excision weight measurement 0.0 0 104204 2927
Crl:WI left kidney wet weight to body weight ratio standard diet Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney mass male 63 days 10 4.2 mg/g 0.09 0.3 post excision weight measurement 0.0 0 104206 2927
MHS artery inner diameter standard diet (for 270 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 270 days 10 12.9 um 0.38 1.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104229 2927
MNS artery inner diameter standard diet (for 63 days) Menini S, et al., J Hypertens. 2004 Nov;22(11):2185-92. kidney blood vessel morphology trait male 63 days 10 18.5 um 1.49 4.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 104226 2927
Crl:CD(SD) plasma lactate level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood lactate amount male 168 days 19 15.1 mg/dl 0.46 2.0 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85368 1604
Crl:CD(SD) plasma creatinine level standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. blood creatinine amount male 133 days 19 0.37 mg/dl 0.0 0.02 automated blood analysis 0.0 0 TBA-120FR, Toshiba corporation, Japan 85374 1604
Crl:CD(SD) urine creatinine excretion rate standard diet Kondo K, et al., J Toxicol Sci. 2012;37(5):911-29. urine creatinine amount male 70 days 19 9.72 mg/d 0.23 1.0 liquid chromatography-mass spectrometry 0.0 0 85386 1604
WKY plasma low density lipoprotein cholesterol level standard diet (for 20 days) Orolin J, et al., Food Chem Toxicol. 2009 Oct;47(10):2624-30. doi: 10.1016/j.fct.2009.07.022. Epub 2009 Jul 25. blood LDL cholesterol amount male 0 days 7 10.04 mg/dl 1.16 3.06 enzymatic cholesterol assay 0.0 0 98910 2178
SD-Abcc6em2Qlju+/- serum phosphate level to plasma pyrophosphate level ratio standard diet Li Q, et al., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19. blood pyrophosphate amount male 60 days-180 days 5 820.6 null 144.1 322.22 liquid phase colorimetry 0.0 0 104662 2972