SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney glomerulus integrity trait |
male |
126 days-182 days |
0 |
76.5 |
/section |
7.0 |
|
ex vivo light microscopy with histochemistry |
renal glomerulus |
0.0 |
0 |
|
107539 |
3090 |
SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney glomerulus integrity trait |
male |
210 days-224 days |
0 |
4.0 |
/section |
2.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107478 |
3088 |
SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
0.0 |
/section |
0.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107548 |
3090 |
SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
1.0 |
/section |
0.4 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107552 |
3090 |
SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney glomerulus integrity trait |
male |
126 days-182 days |
0 |
1.4 |
/section |
1.0 |
|
ex vivo light microscopy with histochemistry |
renal glomerulus |
0.0 |
0 |
|
107540 |
3090 |
SHRSP/A3N |
kidney total tubule cast count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
21.0 |
/section |
11.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
total tubular casts |
107494 |
3088 |
SHRSP/A3N |
renal fibrosis foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
16.4 |
/section |
1.4 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107559 |
3090 |
SHRSP/A3N |
renal fibrosis foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
7.1 |
/section |
0.3 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107560 |
3090 |
SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
6.4 |
/section |
1.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
foci of tubular regeneration |
107485 |
3088 |
SHRSP/A3N |
kidney total tubule cast count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
350.0 |
/section |
80.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
total tubular casts |
107493 |
3088 |
SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney glomerulus integrity trait |
male |
210 days-224 days |
0 |
31.0 |
/section |
5.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107477 |
3088 |
SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
8.5 |
/section |
1.2 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107551 |
3090 |
SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
1.9 |
/section |
1.3 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
foci of tubular regeneration |
107486 |
3088 |
SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
6.6 |
/section |
2.3 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
foci of interstitial nephritis |
107489 |
3088 |
SHRSP/A3N |
renal fibrosis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
25.0 |
/section |
1.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
foci of renal fibrosis |
107497 |
3088 |
SHRSP/A3N |
kidney total tubule cast count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
349.0 |
/section |
45.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107555 |
3090 |
SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
27.3 |
/section |
2.9 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107547 |
3090 |
SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
2.4 |
/section |
0.8 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
foci of interstitial nephritis |
107490 |
3088 |
SHRSP/A3N |
renal fibrosis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
15.0 |
/section |
2.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
foci of renal fibrosis |
107498 |
3088 |
SHRSP/A3N |
kidney total tubule cast count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
4.0 |
/section |
3.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
107556 |
3090 |