| WKY/Izm |
serum total cholesterol level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then controlled fat content diet (26 %) (for 14 days) and controlled potassium content diet (0.44 %) (for 14 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood cholesterol amount |
male |
119 days
| 10 |
|
|
60.4 |
mg/dl |
1.04 |
3.3 |
serum total cholesterol measurement test |
|
|
0 |
|
|
|
12504 |
263 |
| SS/HsdMcwiCrl |
body weight to tibia length ratio |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
body mass |
male |
112 days
| 6 |
|
|
96.12 |
g/cm |
1.28 |
3.14 |
body weighing method |
|
0.0 |
0 |
|
|
|
67616 |
735 |
| SS/HsdMcwiCrl |
heart weight to tibia length ratio |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
heart mass |
male |
112 days
| 6 |
|
|
0.31 |
g/cm |
0.01 |
0.02 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67620 |
735 |
| SS/HsdMcwiCrl |
epididymal fat pad weight to tibia length ratio |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
epididymal fat pad mass |
male |
112 days
| 7 |
|
|
1.17 |
g/cm |
0.05 |
0.13 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67652 |
735 |
| SS/HsdMcwiCrl |
epididymal fat pad weight to tibia length ratio |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
epididymal fat pad mass |
male |
112 days
| 8 |
|
|
1.21 |
g/cm |
0.12 |
0.34 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67655 |
735 |
| SS/HsdMcwiCrl |
water drink intake rate |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
drinking behavior trait |
male |
112 days
| 8 |
|
|
30.1 |
ml/d |
1.8 |
5.09 |
unspecified method |
|
0.0 |
0 |
|
|
|
67663 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 7 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
98.24 |
% |
0.82 |
2.17 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
67673 |
735 |
| SHR/Izm |
adipocyte maximal glucose uptake |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then insulin (50000 pmol/l) (for 1 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte glucose uptake trait |
male |
105 days
| 10 |
|
|
74.3 |
x 1000 cpm/cell |
3.04 |
9.6 |
radioactive glucose uptake assay with liquid scintillation counting |
|
0.0 |
0 |
|
|
|
67927 |
263 |
| WKY/Izm |
serum free fatty acids level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then controlled fat content diet (26 %) (for 14 days) and controlled potassium content diet (0.44 %) (for 14 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood free fatty acid amount |
male |
113 days
| 10 |
|
|
0.03 |
mmol/l |
0.0 |
0.01 |
serum free fatty acid analysis |
|
0.0 |
0 |
|
|
|
67924 |
263 |
| SS/HsdMcwiCrl |
urine total protein excretion rate |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
total urine protein amount |
male |
112 days
| 6 |
|
|
0.6 |
mg/d |
0.1 |
0.24 |
bicinchoninic acid protein assay |
|
0.0 |
0 |
BCA assay |
|
|
69612 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
99.71 |
% |
0.27 |
0.66 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
69616 |
735 |
| BluHsd:LE |
total food calorie intake rate |
controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
2995.2 |
kcal/d |
187.0 |
528.92 |
unspecified method |
|
0.0 |
0 |
|
|
|
76182 |
1543 |
| BluHsd:LE |
both testes wet weight |
bisphenol A (25 ug/kg) (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
testis mass |
male |
98 days
| 8 |
|
|
3.5 |
g |
0.3 |
0.85 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
76251 |
1543 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
logEC50 |
|
-7.2 |
null |
0.1 |
0.24 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
84643 |
735 |
| BluHsd:LE |
food calorie intake level to change in body weight ratio |
controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
10.4 |
kcal/g |
0.3 |
0.85 |
unspecified method |
|
0.0 |
0 |
|
|
|
76198 |
1543 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 4 |
logEC50 |
|
-6.31 |
null |
0.1 |
0.2 |
wire myography |
aorta |
0.0 |
0 |
|
logEC50 |
|
84664 |
735 |
| PXO1/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 11 |
|
|
21.16 |
nm |
0.21 |
0.7 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97684 |
1858 |
| PXO10/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 12 |
|
|
0.54 |
mg/dl |
0.13 |
0.45 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97589 |
1858 |
| PXO8-1/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 10 |
|
|
0.85 |
mg/dl |
0.07 |
0.22 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97591 |
1858 |
| BXH2/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 18 |
|
|
10.7 |
mg/dl |
1.1 |
4.67 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97621 |
1858 |
| PXO7-1/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 8 |
|
|
4.08 |
mg/dl |
0.11 |
0.31 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97566 |
1858 |
| BXH2/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 18 |
|
|
4.18 |
mg/dl |
0.19 |
0.81 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97568 |
1858 |
| BXH2/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 18 |
|
|
12.57 |
nm |
0.06 |
0.25 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97699 |
1858 |
| PXO6-2/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 8 |
|
|
0.41 |
% |
0.04 |
0.11 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97778 |
1858 |
| PXO9/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 9 |
|
|
0.61 |
% |
0.03 |
0.09 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97782 |
1858 |
| PXO5-2/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 10 |
|
|
0.73 |
% |
0.04 |
0.13 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97783 |
1858 |
| PXO7-1/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 8 |
|
|
0.84 |
% |
0.06 |
0.17 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97785 |
1858 |
| PXO10/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 12 |
|
|
0.86 |
% |
0.06 |
0.21 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97786 |
1858 |
| PXO8-1/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 12 |
|
|
0.86 |
% |
0.04 |
0.14 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97788 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 13 |
|
|
0.96 |
% |
0.06 |
0.22 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97790 |
1858 |
| PXO6-3/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 10 |
|
|
20.77 |
nm |
0.17 |
0.54 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97679 |
1858 |
| PXO6-3/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 10 |
|
|
3.2 |
g/kg |
0.0 |
0.0 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97181 |
1858 |
| PXO6-2/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 8 |
|
|
3.7 |
g/kg |
0.2 |
0.57 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97185 |
1858 |
| PXO6-1/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 10 |
|
|
21.47 |
nm |
0.15 |
0.47 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97689 |
1858 |
| PXO5-1/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 11 |
|
|
88.8 |
mg/dl |
6.8 |
22.55 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97329 |
1858 |
| PXO9/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 9 |
|
|
6.0 |
g/kg |
0.1 |
0.3 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97150 |
1858 |
| PXO3-1/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 10 |
|
|
6.3 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97154 |
1858 |
| PXO8-1/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 10 |
|
|
24.9 |
g/kg |
0.3 |
0.95 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97199 |
1858 |
| PXO5-1/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 11 |
|
|
25.5 |
g/kg |
0.2 |
0.66 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97201 |
1858 |
| PXO4/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 9 |
|
|
26.0 |
g/kg |
0.3 |
0.9 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97202 |
1858 |
| PXO10/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 12 |
|
|
7.8 |
mg/dl |
0.44 |
1.52 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97274 |
1858 |
| PXO3-1/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 10 |
|
|
40.4 |
nm |
0.2 |
0.63 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97666 |
1858 |
| PXO4/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 9 |
|
|
27.6 |
mg/dl |
4.5 |
13.5 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97611 |
1858 |
| PXO8-2/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 13 |
|
|
1.24 |
% |
0.03 |
0.11 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97526 |
1858 |
| PXO6-3/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 10 |
|
|
5.9 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97148 |
1858 |
| PXO6-2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 8 |
|
|
61.7 |
mg/dl |
2.6 |
7.35 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97223 |
1858 |
| PXO10/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 12 |
|
|
49.4 |
mg/dl |
2.0 |
6.93 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97212 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 13 |
|
|
53.7 |
mg/dl |
1.2 |
4.33 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97216 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 13 |
|
|
4.1 |
g/kg |
0.2 |
0.72 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97105 |
1858 |
| PXO8-1/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 10 |
|
|
12.56 |
mg/dl |
0.61 |
1.93 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97287 |
1858 |
| PXO6-3/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 10 |
|
|
39.7 |
nm |
0.2 |
0.63 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97664 |
1858 |
| PXO5-1/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 11 |
|
|
14.0 |
mg/100g |
0.5 |
1.66 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97394 |
1858 |
| PXO7-1/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 8 |
|
|
1.25 |
% |
0.01 |
0.03 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97513 |
1858 |
| PXO8-2/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 13 |
|
|
40.8 |
nm |
0.2 |
0.72 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97668 |
1858 |
| PXO9/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 9 |
|
|
0.92 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97522 |
1858 |
| PXO3-2/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 9 |
|
|
10.72 |
mg/dl |
0.65 |
1.95 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97282 |
1858 |
| PXO6-3/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 10 |
|
|
11.02 |
mg/dl |
0.62 |
1.96 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97284 |
1858 |
| PXO6-1/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 10 |
|
|
27.0 |
mg/dl |
1.0 |
3.16 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97315 |
1858 |
| PXO8-2/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 13 |
|
|
59.4 |
mg/dl |
4.8 |
17.31 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97328 |
1858 |
| PXO5-2/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 10 |
|
|
16.6 |
mg/dl |
0.9 |
2.85 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97626 |
1858 |
| PXO8-2/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 13 |
|
|
17.4 |
mg/dl |
0.8 |
2.88 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97628 |
1858 |
| PXO6-1/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 10 |
|
|
18.5 |
mg/dl |
0.5 |
1.58 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97630 |
1858 |
| PXO3-1/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 10 |
|
|
2.58 |
mg/dl |
0.1 |
0.32 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97634 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 13 |
|
|
3.31 |
mg/dl |
0.14 |
0.5 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97640 |
1858 |
| PXO6-2/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 8 |
|
|
1.58 |
mg/dl |
0.2 |
0.57 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97262 |
1858 |
| PXO4/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 9 |
|
|
3.43 |
mg/dl |
0.4 |
1.2 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97265 |
1858 |
| PXO1/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 11 |
|
|
7.32 |
mg/dl |
1.11 |
3.68 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97273 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 13 |
|
|
6.85 |
mg/dl |
0.53 |
1.91 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97271 |
1858 |
| PXO5-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 11 |
|
|
36.37 |
mg/dl |
1.47 |
4.88 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97304 |
1858 |
| PXO1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 11 |
|
|
27.54 |
mg/dl |
1.8 |
5.97 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97299 |
1858 |
| PXO9/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 9 |
|
|
31.0 |
mg/dl |
3.1 |
9.3 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97318 |
1858 |
| PXO6-1/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 10 |
|
|
0.81 |
mg/dl |
0.12 |
0.38 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97240 |
1858 |
| PXO9/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 9 |
|
|
4.35 |
mg/dl |
0.19 |
0.57 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97570 |
1858 |
| PXO8-2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 13 |
|
|
61.0 |
mg/dl |
1.3 |
4.69 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97222 |
1858 |
| SHRSP/A3NCrl |
body weight |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
body mass |
male |
134 days-141 days |
10 |
|
|
345.0 |
g |
14.0 |
44.27 |
body weighing method |
|
0.0 |
0 |
|
HSFD +3.0 mg/kg/day BAY 60-4552 |
|
106964 |
3073 |
| SHRSP/A3NCrl |
body weight |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
body mass |
male |
134 days-141 days |
9 |
|
|
328.0 |
g |
6.0 |
18.0 |
body weighing method |
|
0.0 |
0 |
|
HSFD +0.3 mg/kg/day BAY 60-4552 |
|
106963 |
3073 |
| SHRSP/A3NCrl |
end-diastolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
9 |
|
|
0.36 |
ml |
0.02 |
0.06 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106969 |
3073 |
| SHRSP/A3NCrl |
ejection fraction |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
11 |
|
|
69.0 |
% |
1.0 |
3.32 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107023 |
3073 |
| SHRSP/A3NCrl |
stroke volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
11 |
|
|
229000.0 |
ml |
10000.0 |
33166.25 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107029 |
3073 |
| SHRSP/A3NCrl |
stroke volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
6 |
|
|
222000.0 |
ml |
19000.0 |
46540.31 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107030 |
3073 |
| SHRSP/A3NCrl |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
heart left ventricle mass |
male |
134 days-141 days |
11 |
|
|
3.08 |
mg/g |
0.06 |
0.2 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
LV mass calculated from 2-D images with area-length method |
|
107035 |
3073 |
| SHRSP/A3NCrl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
9 |
|
|
0.19 |
10E-7mol/l |
0.05 |
0.15 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
nanoMolar |
|
107088 |
3073 |
| SHRSP/A3NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
9 |
|
|
100.0 |
% |
2.0 |
6.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107094 |
3073 |
| SHRSP/A3N |
heart rate |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
189 days-210 days |
0 |
|
|
277.0 |
beats/min |
6.0 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet |
|
107130 |
3075 |
| SHRSP/A3N |
end-diastolic volume |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
203 days-224 days |
8 |
|
|
0.61 |
ml |
0.02 |
0.06 |
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet |
|
107133 |
3075 |
| SHRSP/A3NCrl |
concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
8 |
|
|
260.0 |
nmol/l |
74.0 |
209.3 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107300 |
3073 |
| SHRSP/A3NCrl |
systolic blood pressure |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
arterial blood pressure trait |
male |
161 days-175 days |
8 |
|
|
143.0 |
mmHg |
6.0 |
16.97 |
tail cuff plethysmography |
|
0.0 |
0 |
|
|
|
107384 |
3083 |
| SHRSP/A3NCrl |
blood urea nitrogen level |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
blood urea nitrogen amount |
male |
161 days-175 days |
6 |
|
|
20.5 |
mg/dl |
5.8 |
14.21 |
blood urea nitrogen analysis |
|
0.0 |
0 |
|
|
|
107391 |
3083 |
| SHRSP/A3N |
ratio of deaths related to chronic hypertension to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 84 days) and controlled fat content diet (24.5 %) (for 84 days) and eprosartan (60 mg/kg/d) (for 84 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
total life span |
male |
168 days-189 days |
25 |
|
|
0.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of deaths related to chronic hypertension to total study population during a period of time (CMO:0003800) |
|
107519 |
3090 |
| SHRSP/A3N |
body weight |
controlled sodium chloride content drinking water (1 %) (for 42 days) and controlled fat content diet (24.5 %) (for 42 days) and vehicle control condition (for 42 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
body mass |
male |
126 days-147 days |
0 |
|
|
254.0 |
g |
7.0 |
|
body weighing method |
|
0.0 |
0 |
|
|
|
107527 |
3090 |
| SHRSP/A3N |
renal fibrosis foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
|
|
7.1 |
/section |
0.3 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107560 |
3090 |
| SHRSP/A3N |
plasma aldosterone level |
controlled sodium content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) |
Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. |
blood aldosterone amount |
male |
182 days-210 days |
8 |
|
|
347.0 |
pg/ml |
72.0 |
203.65 |
radioimmunoassay |
|
0.0 |
0 |
|
|
|
107938 |
3100 |
| SHRSP/A3N |
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) and controlled enrasentan content diet (2400 ppm) (for 112 days) |
Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. |
total life span |
male |
182 days-210 days |
20 |
|
|
10.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time (CMO:0003810) |
|
107936 |
3100 |
| SHRSP/A3NCrl |
end-systolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
120000.0 |
ml |
9000.0 |
28460.5 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106976 |
3073 |
| SHRSP/A3NCrl |
timed urine volume |
controlled sodium content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine output |
male |
99 days-148 days |
9 |
|
|
79.0 |
ml/d |
11.0 |
33.0 |
metabolic cage urine volume measurement method |
|
86400.0 |
0 |
8 week HSFD plus treatment |
8 week high salt high fat plus treatment |
|
107055 |
3073 |
| SHRSP/A3NCrl |
urine albumin excretion rate |
controlled sodium content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine albumin amount |
male |
99 days-148 days |
9 |
|
|
142.0 |
mg/d |
42.0 |
126.0 |
urine microalbumin analysis |
|
86400.0 |
0 |
8 week HSFD plus treatment |
8 week high salt high fat plus treatment |
|
107061 |
3073 |
| SHRSP/A3NCrl |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
heart left ventricle mass |
male |
134 days-141 days |
10 |
|
|
2.82 |
mg/g |
0.07 |
0.22 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
LV mass calculated from 2-D images with area-length method |
|
107037 |
3073 |
| SHRSP/A3NCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
9 |
|
|
91.0 |
% |
8.0 |
24.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) |
|
107076 |
3073 |
| SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
|
|
27.3 |
/section |
2.9 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107547 |
3090 |
| SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
|
|
8.5 |
/section |
1.2 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107551 |
3090 |
| SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
|
|
1.0 |
/section |
0.4 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107552 |
3090 |
| SHRSP/A3N |
kidney total tubule cast count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
|
|
350.0 |
/section |
80.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
total tubular casts |
|
107493 |
3088 |
| SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
|
|
2.4 |
/section |
0.8 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of interstitial nephritis |
|
107490 |
3088 |
| SHRSP/A3N |
systolic blood pressure |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
arterial blood pressure trait |
male |
203 days-224 days |
10 |
|
|
267.0 |
mmHg |
7.0 |
22.14 |
tail cuff plethysmography |
tail |
0.0 |
0 |
|
high salt high fat diet |
|
107096 |
3075 |
| SHRSP/A3N |
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
total life span |
male |
203 days-224 days |
20 |
|
|
55.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time (CMO:0003810) |
|
107113 |
3075 |
| SHRSP/A3N |
heart rate |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
203 days-224 days |
8 |
|
|
285.0 |
beats/min |
15.0 |
42.43 |
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet |
|
107137 |
3075 |
| SHRSP/A3NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
4 |
|
|
111.0 |
% |
3.0 |
6.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107093 |
3073 |
| SHRSP/A3N |
end-systolic volume |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
189 days-210 days |
0 |
|
|
0.29 |
ml |
0.04 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet |
|
107126 |
3075 |
| SHRSP/A3NCrl |
ratio of survivors of severe albuminuria to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
life span trait |
male |
161 days-175 days |
10 |
|
|
80.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of survivors of severe albuminuria to total study population during a period of time (CMO:0003630) |
|
109031 |
3083 |
| SD-Ldlrem1Sage |
plasma alanine aminotransferase activity level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood alanine transaminase amount |
male |
448 days
| 16 |
|
|
209.0 |
U/l |
71.0 |
284.0 |
automated plasma alanine aminotransferase activity assay |
|
0.0 |
0 |
|
|
|
138288 |
3201 |
| SD-Ldlrem1Sage |
liver cholesterol level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
liver cholesterol amount |
male |
448 days
| 16 |
|
|
35.43 |
mg/g |
3.17 |
12.68 |
isolated tissue cholesterol measurement test |
|
0.0 |
0 |
|
|
|
138345 |
3201 |
| SD-Ldlrem1Sage |
plasma creatinine level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood creatinine amount |
male |
448 days
| 16 |
|
|
2.45 |
mg/dl |
0.79 |
3.16 |
automated plasma creatinine analysis |
|
0.0 |
0 |
|
|
|
138301 |
3201 |
| SD-Ldlrem1Sage |
plasma leptin level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood leptin amount |
male |
448 days
| 16 |
|
|
65.59 |
ng/ml |
7.52 |
30.08 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138317 |
3201 |
| Hsd:SD |
plasma free fatty acids level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood free fatty acid amount |
male |
448 days
| 10 |
|
|
1.23 |
mmol/l |
0.15 |
0.47 |
plasma free fatty acid analysis |
|
0.0 |
0 |
|
|
|
138324 |
3201 |
| SS/HsdMcwiCrl |
water drink intake rate |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
drinking behavior trait |
male |
112 days
| 7 |
|
|
18.4 |
ml/d |
2.4 |
6.35 |
unspecified method |
|
0.0 |
0 |
|
|
|
67665 |
735 |
| SHR/Izm |
serum free fatty acids level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then controlled fat content diet (26 %) (for 14 days) and controlled potassium content diet (0.44 %) (for 14 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood free fatty acid amount |
male |
113 days
| 10 |
|
|
0.02 |
mmol/l |
0.0 |
0.01 |
serum free fatty acid analysis |
|
0.0 |
0 |
|
|
|
67922 |
263 |
| SS/HsdMcwiCrl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 7 |
logEC50 |
|
-7.9 |
null |
0.12 |
0.32 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
84648 |
735 |
| SS/HsdMcwiCrl |
urine total protein excretion rate |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
total urine protein amount |
male |
112 days
| 6 |
|
|
0.7 |
mg/d |
0.07 |
0.17 |
bicinchoninic acid protein assay |
|
0.0 |
0 |
|
|
|
69614 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 7 |
logEC50 |
|
-6.33 |
null |
0.25 |
0.66 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84665 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 0 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
95.47 |
% |
2.53 |
|
wire myography |
aorta |
0.0 |
0 |
BCA assay |
|
|
84662 |
735 |
| SS/HsdMcwiCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 6 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
542.39 |
% |
49.85 |
122.11 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
phenylephrine-induced blood vessel constriction expressed as percent of force at baseline |
|
84674 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
logEC50 |
|
-8.24 |
null |
0.13 |
0.32 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84671 |
735 |
| PXO5-2/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 10 |
|
|
220.6 |
g |
3.3 |
10.44 |
body weighing method |
|
0.0 |
0 |
|
|
|
97157 |
1858 |
| PXO4/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 9 |
|
|
21.1 |
nm |
0.1 |
0.3 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97683 |
1858 |
| PXO5-2/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 10 |
|
|
3.85 |
mg/dl |
0.31 |
0.98 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97596 |
1858 |
| PXO3-1/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 10 |
|
|
12.71 |
nm |
0.02 |
0.06 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97703 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 13 |
|
|
328.0 |
g |
4.0 |
14.42 |
body weighing method |
|
0.0 |
0 |
|
|
|
97101 |
1858 |
| PXO1/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 11 |
|
|
3.5 |
g/kg |
0.2 |
0.66 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97184 |
1858 |
| PXO7-1/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 8 |
|
|
5.8 |
g/kg |
0.1 |
0.28 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97127 |
1858 |
| PXO10/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 12 |
|
|
7.3 |
g/kg |
0.1 |
0.35 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97155 |
1858 |
| PXO6-3/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 10 |
|
|
26.1 |
g/kg |
0.4 |
1.26 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97203 |
1858 |
| PXO3-2/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 9 |
|
|
0.99 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97501 |
1858 |
| PXO5-1/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 11 |
|
|
1.32 |
% |
0.03 |
0.1 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97530 |
1858 |
| PXO5-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 11 |
|
|
53.3 |
mg/dl |
2.4 |
7.96 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97214 |
1858 |
| PXO1/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 11 |
|
|
14.0 |
mg/100g |
0.8 |
2.65 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97395 |
1858 |
| PXO5-2/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 10 |
|
|
1.24 |
% |
0.01 |
0.03 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97512 |
1858 |
| PXO6-2/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 8 |
|
|
0.87 |
% |
0.03 |
0.08 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97515 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 13 |
|
|
0.89 |
% |
0.03 |
0.11 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97518 |
1858 |
| PXO2/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 11 |
|
|
5.0 |
mg/dl |
0.51 |
1.69 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97269 |
1858 |
| PXO9/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 9 |
|
|
7.02 |
mg/dl |
1.08 |
3.24 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97272 |
1858 |
| PXO8-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
|
|
45.97 |
mg/dl |
1.02 |
3.23 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97310 |
1858 |
| PXO6-3/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 10 |
|
|
15.0 |
mg/100g |
1.1 |
3.48 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97399 |
1858 |
| SHR/Izm |
serum total cholesterol level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then controlled fat content diet (26 %) (for 14 days) and controlled potassium content diet (0.44 %) (for 14 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood cholesterol amount |
male |
119 days
| 10 |
|
|
136.1 |
mg/dl |
10.09 |
31.9 |
serum total cholesterol measurement test |
|
|
0 |
|
|
|
12458 |
263 |
| SHR/Izm |
serum triglyceride level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then controlled fat content diet (26 %) (for 14 days) and controlled potassium content diet (0.44 %) (for 14 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood triglyceride amount |
male |
113 days
| 10 |
|
|
23.8 |
mg/dl |
3.83 |
12.1 |
serum triglyceride analysis |
|
|
0 |
|
|
|
12478 |
263 |
| SHR/Izm |
systolic blood pressure |
controlled fat content diet (5 %) (for 63 days) and controlled potassium content diet (0.75 %) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
arterial blood pressure trait |
male |
91 days
| 10 |
|
|
185.9 |
mmHg |
2.09 |
6.6 |
tail cuff plethysmography |
|
|
0 |
|
|
|
13276 |
263 |
| WKY/Izm |
systolic blood pressure |
controlled fat content diet (5 %) (for 63 days) and controlled potassium content diet (0.75 %) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
arterial blood pressure trait |
male |
91 days
| 10 |
|
|
132.2 |
mmHg |
2.18 |
6.9 |
tail cuff plethysmography |
|
|
0 |
|
|
|
13277 |
263 |
| SS/HsdMcwiCrl |
heart weight to tibia length ratio |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
heart mass |
male |
112 days
| 8 |
|
|
0.32 |
g/cm |
0.01 |
0.03 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67621 |
735 |
| SS/HsdMcwiCrl |
food intake rate |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
eating behavior trait |
male |
112 days
| 7 |
|
|
20.9 |
g/d |
1.4 |
3.7 |
unspecified method |
|
0.0 |
0 |
|
|
|
67661 |
735 |
| SS/HsdMcwiCrl |
urine sodium excretion rate |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
urine sodium amount |
male |
112 days
| 7 |
|
|
6.0 |
mEq/d |
0.9 |
2.38 |
automated urine analysis |
|
0.0 |
0 |
|
|
|
67667 |
735 |
| SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 7 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
97.36 |
% |
0.65 |
1.72 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
67671 |
735 |
| SS/HsdMcwiCrl |
body weight to tibia length ratio |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
body mass |
male |
112 days
| 7 |
|
|
100.21 |
g/cm |
1.76 |
4.66 |
body weighing method |
|
0.0 |
0 |
|
|
|
67614 |
735 |
| SS/HsdMcwiCrl |
tibia length |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
tibia length |
male |
112 days
| 8 |
|
|
4.34 |
cm |
0.03 |
0.08 |
unspecified method |
|
0.0 |
0 |
|
|
|
67613 |
735 |
| WKY/Izm |
adipocyte maximal glucose uptake |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then insulin (50000 pmol/l) (for 1 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte glucose uptake trait |
male |
105 days
| 10 |
|
|
144.5 |
x 1000 cpm/cell |
3.48 |
11.0 |
radioactive glucose uptake assay with liquid scintillation counting |
|
0.0 |
0 |
|
|
|
67928 |
263 |
| WKY/Izm |
absolute change in adipocyte free fatty acid secretion |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then isoproterenol (200 nmol/l) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte free fatty acid secretion trait |
male |
105 days
| 10 |
|
|
8.39 |
pmol/cell |
0.57 |
1.79 |
lipolysis assay measuring free fatty acid release |
|
0.0 |
0 |
|
|
|
67934 |
263 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
100.14 |
% |
0.37 |
0.91 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
69619 |
735 |
| BluHsd:LE |
body weight gain |
controlled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
body mass |
male |
71 days-98 days |
8 |
|
|
150.1 |
g |
4.7 |
13.29 |
body weighing method |
|
0.0 |
0 |
|
|
|
76163 |
1543 |
| BluHsd:LE |
total food calorie intake rate |
controlled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
2990.7 |
kcal/d |
136.6 |
386.36 |
unspecified method |
|
0.0 |
0 |
|
|
|
76183 |
1543 |
| SS/HsdMcwiCrl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
logEC50 |
|
-7.9 |
null |
0.17 |
0.42 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
84650 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 5 |
logEC50 |
|
-6.7 |
null |
0.2 |
0.45 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
84647 |
735 |
| BluHsd:LE |
both testes wet weight |
bisphenol A (2.5 ug/kg) (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
testis mass |
male |
98 days
| 8 |
|
|
3.5 |
g |
0.4 |
1.13 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
76250 |
1543 |
| SS/HsdMcwiCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 7 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
694.94 |
% |
34.53 |
91.36 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
phenylephrine-induced blood vessel constriction expressed as percent of force at baseline |
|
84672 |
735 |
| SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
96.25 |
% |
1.6 |
5.06 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
|
|
84661 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
logEC50 |
|
-7.93 |
null |
0.15 |
0.47 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84669 |
735 |
| SS/HsdMcwiCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 9 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
626.89 |
% |
61.39 |
184.17 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
phenylephrine-induced blood vessel constriction expressed as percent of force at baseline |
|
84677 |
735 |
| PXO10/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 12 |
|
|
295.6 |
g |
7.2 |
24.94 |
body weighing method |
|
0.0 |
0 |
|
|
|
97168 |
1858 |
| PXO5-2/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 10 |
|
|
12.45 |
nm |
0.04 |
0.13 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97697 |
1858 |
| PXO8-1/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 10 |
|
|
28.6 |
mg/dl |
2.6 |
8.22 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97613 |
1858 |
| PXO4/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 9 |
|
|
3.84 |
mg/dl |
0.19 |
0.57 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97564 |
1858 |
| PXO3-2/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 9 |
|
|
12.58 |
nm |
0.03 |
0.09 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97700 |
1858 |
| PXO6-3/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 10 |
|
|
12.43 |
nm |
0.06 |
0.19 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97696 |
1858 |
| PXO3-2/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 9 |
|
|
0.48 |
% |
0.04 |
0.12 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97780 |
1858 |
| PXO4/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 9 |
|
|
0.46 |
% |
0.03 |
0.09 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97779 |
1858 |
| PXO8-2/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 13 |
|
|
0.87 |
% |
0.03 |
0.11 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97787 |
1858 |
| PXO6-2/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 8 |
|
|
12.39 |
nm |
0.02 |
0.06 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97695 |
1858 |
| PXO9/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 9 |
|
|
4.0 |
g/kg |
0.1 |
0.3 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97192 |
1858 |
| PXO3-2/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 9 |
|
|
20.36 |
nm |
0.05 |
0.15 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97676 |
1858 |
| PXO3-1/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 10 |
|
|
10.28 |
mg/dl |
0.28 |
0.89 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97280 |
1858 |
| PXO5-2/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 10 |
|
|
6.0 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97156 |
1858 |
| PXO1/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 11 |
|
|
22.37 |
mg/dl |
1.06 |
3.52 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97295 |
1858 |
| PXO3-2/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 9 |
|
|
26.2 |
g/kg |
0.4 |
1.2 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97204 |
1858 |
| PXO5-2/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 10 |
|
|
10.68 |
mg/dl |
0.89 |
2.81 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97275 |
1858 |
| PXO2/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 11 |
|
|
1.25 |
% |
0.05 |
0.17 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97527 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 13 |
|
|
0.53 |
mg/dl |
0.08 |
0.29 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97587 |
1858 |
| PXO6-3/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 10 |
|
|
13.1 |
mg/dl |
1.3 |
4.11 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97602 |
1858 |
| PXO2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 11 |
|
|
74.1 |
mg/dl |
1.8 |
5.97 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97226 |
1858 |
| PXO6-1/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 10 |
|
|
38.6 |
nm |
0.4 |
1.26 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97657 |
1858 |
| PXO5-2/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 10 |
|
|
92.4 |
mg/dl |
6.6 |
20.87 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97330 |
1858 |
| PXO9/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 9 |
|
|
13.0 |
mg/100g |
1.0 |
3.0 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97391 |
1858 |
| PXO7-1/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 8 |
|
|
15.0 |
mg/100g |
0.5 |
1.41 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97396 |
1858 |
| PXO8-1/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 10 |
|
|
1.06 |
% |
0.01 |
0.03 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97505 |
1858 |
| PXO4/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 9 |
|
|
0.87 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97516 |
1858 |
| PXO1/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 11 |
|
|
1.12 |
% |
0.02 |
0.07 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97509 |
1858 |
| PXO1/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 11 |
|
|
0.9 |
% |
0.02 |
0.07 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97520 |
1858 |
| PXO6-2/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 8 |
|
|
13.96 |
mg/dl |
0.76 |
2.15 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97288 |
1858 |
| PXO7-1/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 8 |
|
|
51.9 |
mg/dl |
3.6 |
10.18 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97326 |
1858 |
| PXO1/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 11 |
|
|
12.6 |
mg/dl |
0.7 |
2.32 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97623 |
1858 |
| PXO8-1/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 10 |
|
|
17.3 |
mg/dl |
0.9 |
2.85 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97627 |
1858 |
| PXO4/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 9 |
|
|
21.6 |
mg/dl |
1.1 |
3.3 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97633 |
1858 |
| PXO7-1/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 8 |
|
|
3.71 |
mg/dl |
0.13 |
0.37 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97642 |
1858 |
| PXO1/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 11 |
|
|
3.78 |
mg/dl |
0.14 |
0.46 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97644 |
1858 |
| PXO5-2/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 10 |
|
|
5.21 |
mg/dl |
0.16 |
0.51 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97649 |
1858 |
| PXO6-3/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 10 |
|
|
1.36 |
mg/dl |
0.14 |
0.44 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97260 |
1858 |
| PXO5-1/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 11 |
|
|
6.31 |
mg/dl |
0.45 |
1.49 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97270 |
1858 |
| PXO3-2/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 9 |
|
|
0.02 |
mg/dl |
0.0 |
0.01 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97347 |
1858 |
| PXO9/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 9 |
|
|
0.08 |
mg/dl |
0.02 |
0.06 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97354 |
1858 |
| PXO5-2/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 10 |
|
|
0.42 |
mg/dl |
0.05 |
0.16 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97360 |
1858 |
| PXO5-2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
|
|
32.16 |
mg/dl |
1.52 |
4.81 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97302 |
1858 |
| PXO3-1/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 10 |
|
|
27.4 |
mg/dl |
0.9 |
2.85 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97316 |
1858 |
| PXO2/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 11 |
|
|
31.9 |
mg/dl |
2.2 |
7.3 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97319 |
1858 |
| PXO3-2/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 9 |
|
|
37.4 |
mg/dl |
3.8 |
11.4 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97322 |
1858 |
| PXO7-1/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 8 |
|
|
27.3 |
g/kg |
0.3 |
0.85 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97208 |
1858 |
| PXO3-2/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 9 |
|
|
17.0 |
mg/100g |
0.3 |
0.9 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97401 |
1858 |
| PXO6-1/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 10 |
|
|
20.0 |
mg/100g |
0.6 |
1.9 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97407 |
1858 |
| PXO6-1/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 10 |
|
|
23.8 |
g/kg |
0.3 |
0.95 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97196 |
1858 |
| PXO8-1/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 10 |
|
|
4.47 |
mg/dl |
0.2 |
0.63 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97571 |
1858 |
| PXO5-2/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 10 |
|
|
5.84 |
mg/dl |
0.28 |
0.89 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97576 |
1858 |
| SHRSP/A3NCrl |
ratio of survivors to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
life span trait |
male |
141 days-148 days |
8 |
|
|
14.0 |
% |
|
|
Kaplan-Meier estimate |
|
0.0 |
0 |
|
|
|
107041 |
3073 |
| SHRSP/A3NCrl |
cardiac output |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
80.0 |
ml/min |
5.0 |
15.81 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106999 |
3073 |
| SHRSP/A3NCrl |
stroke volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
259000.0 |
ml |
13000.0 |
41109.61 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107033 |
3073 |
| SHRSP/A3NCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
6 |
|
|
88.0 |
% |
6.0 |
14.7 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) |
|
107073 |
3073 |
| SHRSP/A3NCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
9 |
|
|
89.0 |
% |
7.0 |
21.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) |
|
107074 |
3073 |
| SHRSP/A3NCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
4 |
|
|
93.0 |
% |
8.0 |
16.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) |
|
107075 |
3073 |
| SHRSP/A3NCrl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
4 |
|
|
0.26 |
10E-7mol/l |
0.15 |
0.3 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
nanoMolar |
|
107087 |
3073 |
| SHRSP/A3NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
8 |
|
|
103.0 |
% |
9.0 |
25.46 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107090 |
3073 |
| SHRSP/A3NCrl |
carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
8 |
|
|
47.0 |
% |
11.0 |
31.11 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107294 |
3073 |
| SHRSP/A3NCrl |
carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
6 |
|
|
54.0 |
% |
6.0 |
14.7 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107295 |
3073 |
| SHRSP/A3NCrl |
concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
4 |
|
|
407.0 |
nmol/l |
158.0 |
316.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107304 |
3073 |
| SHRSP/A3NCrl |
time to peak measurement of Gd-DTPA uptake by kidney cortex |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (between 35 and 63 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
xenobiotic metabolism trait |
male |
161 days-175 days |
8 |
|
|
10.2 |
s |
1.3 |
9.96 |
Dynamic Contrast-Enhanced Magnetic Resonance Imaging |
cortex of kidney |
400.0 |
0 |
5 seconds x 10 measurements averaged x 8 regions |
5 seconds x 10 measurements averaged x 8 regions |
|
107375 |
3083 |
| SHRSP/A3NCrl |
time to peak measurement of Gd-DTPA uptake by kidney cortex |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
xenobiotic metabolism trait |
male |
161 days-175 days |
6 |
|
|
14.3 |
s |
1.2 |
17.98 |
Dynamic Contrast-Enhanced Magnetic Resonance Imaging |
cortex of kidney |
400.0 |
0 |
5 seconds x 10 measurements averaged x 8 regions |
5 seconds x 10 measurements averaged x 8 regions |
|
107374 |
3083 |
| SHRSP/A3NCrl |
urine albumin excretion rate |
controlled fat content diet (24.5 %) (for 56 days) and controlled sodium chloride content drinking water (1 %) (for 56 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
urine albumin amount |
male |
126 days-140 days |
6 |
|
|
22.9 |
mg/d |
5.1 |
12.49 |
urine albumin analysis |
|
0.0 |
0 |
immunoturbidimetric assay |
baseline vehicle group |
|
107376 |
3083 |
| SHRSP/A3NCrl |
urine albumin excretion rate |
controlled fat content diet (24.5 %) (for 56 days) and controlled sodium chloride content drinking water (1 %) (for 56 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
urine albumin amount |
male |
126 days-140 days |
8 |
|
|
28.6 |
mg/d |
10.5 |
29.7 |
urine albumin analysis |
|
0.0 |
0 |
immunoturbidimetric assay |
baseline SB-239063 group |
|
107377 |
3083 |
| SHRSP/A3NCrl |
multiregional glomerular filtration rate index |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (between 35 and 63 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
glomerular filtration trait |
male |
161 days-175 days |
6 |
dCm/dt = KclCc(t) |
|
2.25 |
mmol/min |
0.14 |
0.34 |
Dynamic Contrast-Enhanced Magnetic Resonance Imaging |
|
400.0 |
0 |
5 sec x 10 measurements x 8 regions |
glomerular filtration rate index |
|
107379 |
3083 |
| SHRSP/A3NCrl |
multiregional glomerular filtration rate index |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (between 35 and 63 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
glomerular filtration trait |
male |
161 days-175 days |
8 |
dCm/dt = KclCc(t) |
|
3.12 |
mmol/min |
0.23 |
0.65 |
Dynamic Contrast-Enhanced Magnetic Resonance Imaging |
|
400.0 |
0 |
5 sec x 10 measurements x 8 regions |
glomerular filtration rate index |
|
107378 |
3083 |
| SHRSP/A3N |
urine total protein excretion rate |
controlled sodium chloride content drinking water (1 %) (between 35 and 49 days) and controlled fat content diet (24.5 %) (between 35 and 49 days) and eprosartan (60 mg/kg/d) (between 35 and 49 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
total urine protein amount |
male |
119 days-154 days |
0 |
|
|
22.0 |
mg/d |
2.0 |
|
urine protein analysis |
|
86400.0 |
0 |
|
|
|
107521 |
3090 |
| SHRSP/A3N |
kidney total tubule cast count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
|
|
349.0 |
/section |
45.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107555 |
3090 |
| SHRSP/A3N |
renal fibrosis foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
|
|
16.4 |
/section |
1.4 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107559 |
3090 |
| SHRSP/A3N |
plasma aldosterone level |
controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) and controlled enrasentan content diet (1200 ppm) (for 112 days) |
Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. |
blood aldosterone amount |
male |
182 days-210 days |
8 |
|
|
146.0 |
pg/ml |
26.0 |
73.54 |
radioimmunoassay |
|
0.0 |
0 |
|
|
|
107939 |
3100 |
| SHRSP/A3N |
urine total protein excretion rate |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
urine protein amount |
male |
210 days-224 days |
0 |
|
|
37.0 |
mg/d |
15.0 |
|
urine protein analysis |
|
86400.0 |
0 |
metabolic cage; sulfosalicylic acid method |
|
|
107474 |
3088 |
| SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney glomerulus integrity trait |
male |
210 days-224 days |
0 |
|
|
31.0 |
/section |
5.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107477 |
3088 |
| SHRSP/A3N |
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) |
Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. |
total life span |
male |
182 days-210 days |
20 |
|
|
65.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time (CMO:0003810) |
|
107934 |
3100 |
| SHRSP/A3NCrl |
end-systolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
6 |
|
|
110000.0 |
ml |
11000.0 |
26944.39 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106973 |
3073 |
| SHRSP/A3NCrl |
timed urine volume |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine output |
male |
99 days-148 days |
9 |
|
|
56.0 |
ml/d |
10.0 |
30.0 |
metabolic cage urine volume measurement method |
|
86400.0 |
0 |
8 week HSFD plus treatment |
8 week high salt high fat plus treatment |
|
107056 |
3073 |
| SHRSP/A3NCrl |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
heart left ventricle mass |
male |
134 days-141 days |
6 |
|
|
2.69 |
mg/g |
0.08 |
0.2 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
LV mass calculated from 2-D images with area-length method |
|
107036 |
3073 |
| SHRSP/A3NCrl |
concentration of GSK2181236A at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
8 |
|
|
321.0 |
nmol/l |
168.0 |
475.18 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
high salt high fat diet |
|
107311 |
3073 |
| SHRSP/A3N |
renal fibrosis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
|
|
25.0 |
/section |
1.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of renal fibrosis |
|
107497 |
3088 |
| SHRSP/A3N |
renal fibrosis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
|
|
15.0 |
/section |
2.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of renal fibrosis |
|
107498 |
3088 |
| SHRSP/A3N |
end-systolic volume |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
203 days-224 days |
8 |
|
|
0.25 |
ml |
0.02 |
0.06 |
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet |
|
107135 |
3075 |
| SHRSP/A3N |
body weight |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
body mass |
male |
203 days-224 days |
10 |
|
|
367.0 |
g |
10.0 |
31.62 |
body weighing method |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
|
107103 |
3075 |
| Hsd:SD |
plasma aspartate aminotransferase activity level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood aspartate transaminase amount |
male |
448 days
| 10 |
|
|
140.0 |
U/l |
20.0 |
63.25 |
automated plasma aspartate aminotransferase activity assay |
|
0.0 |
0 |
|
|
|
138291 |
3201 |
| Hsd:SD |
blood high density lipoprotein particle diameter |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood HDL particle size |
male |
448 days
| 16 |
|
|
8.9 |
nm |
0.1 |
0.4 |
nuclear magnetic resonance spectroscopy |
|
0.0 |
0 |
|
|
|
138341 |
3201 |
| Hsd:SD |
liver cholesterol level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
liver cholesterol amount |
male |
448 days
| 10 |
|
|
21.11 |
mg/g |
3.4 |
10.75 |
isolated tissue cholesterol measurement test |
|
0.0 |
0 |
|
|
|
138344 |
3201 |
| Hsd:SD |
liver triglyceride level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
liver triglyceride amount |
male |
448 days
| 10 |
|
|
7.76 |
mg/g |
0.72 |
2.28 |
isolated tissue triglyceride measurement test |
|
0.0 |
0 |
|
|
|
138348 |
3201 |
| SD-Ldlrem1Sage |
blood urea nitrogen level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood urea nitrogen amount |
male |
448 days
| 16 |
|
|
13.0 |
mg/dl |
2.0 |
8.0 |
automated blood urea nitrogen analysis |
|
0.0 |
0 |
|
|
|
138305 |
3201 |
| Hsd:SD |
plasma plasminogen activator inhibitor 1 level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood plasminogen activator inhibitor 1 amount |
male |
448 days
| 10 |
|
|
12.86 |
ng/ml |
1.6 |
5.06 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138308 |
3201 |
| SS/HsdMcwiCrl |
both kidneys wet weight to tibia length ratio |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
kidney mass |
male |
112 days
| 8 |
|
|
0.75 |
g/cm |
0.03 |
0.08 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67643 |
735 |
| SS/HsdMcwiCrl |
food intake rate |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
eating behavior trait |
male |
112 days
| 5 |
|
|
25.4 |
g/d |
1.2 |
2.68 |
unspecified method |
|
0.0 |
0 |
|
|
|
67662 |
735 |
| WKY/Izm |
serum total cholesterol level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (for 70 days) then fasting |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood cholesterol amount |
male |
98 days
| 10 |
|
|
73.3 |
mg/dl |
2.34 |
7.4 |
serum total cholesterol measurement test |
|
|
0 |
|
|
|
12495 |
263 |
| BluHsd:LE |
body weight |
controlled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
body mass |
male |
98 days
| 8 |
|
|
485.7 |
g |
16.9 |
47.8 |
body weighing method |
|
0.0 |
0 |
|
|
|
76154 |
1543 |
| BluHsd:LE |
body weight gain |
controlled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
body mass |
male |
71 days-98 days |
8 |
|
|
146.1 |
g |
9.1 |
25.74 |
body weighing method |
|
0.0 |
0 |
|
|
|
76162 |
1543 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
logEC50 |
|
-7.2 |
null |
0.1 |
0.24 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
84642 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 5 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
94.99 |
% |
0.39 |
0.87 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
69620 |
735 |
| SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
98.76 |
% |
0.68 |
1.67 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
|
|
84660 |
735 |
| PXO2/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 11 |
|
|
270.2 |
g |
4.7 |
15.59 |
body weighing method |
|
0.0 |
0 |
|
|
|
97164 |
1858 |
| PXO3-1/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 10 |
|
|
306.3 |
g |
5.1 |
16.13 |
body weighing method |
|
0.0 |
0 |
|
|
|
97170 |
1858 |
| PXO9/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 9 |
|
|
0.54 |
mg/dl |
0.11 |
0.33 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97588 |
1858 |
| PXO5-1/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 11 |
|
|
12.35 |
nm |
0.07 |
0.23 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97693 |
1858 |
| PXO7-1/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 8 |
|
|
3.3 |
g/kg |
0.1 |
0.28 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97182 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 13 |
|
|
13.0 |
nm |
0.03 |
0.11 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97708 |
1858 |
| PXO8-2/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 13 |
|
|
20.81 |
nm |
0.05 |
0.18 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97680 |
1858 |
| PXO7-1/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 8 |
|
|
250.9 |
g |
3.8 |
10.75 |
body weighing method |
|
0.0 |
0 |
|
|
|
97161 |
1858 |
| PXO6-2/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 8 |
|
|
20.9 |
nm |
0.07 |
0.2 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97681 |
1858 |
| PXO10/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 12 |
|
|
23.5 |
mg/dl |
2.6 |
9.01 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97314 |
1858 |
| PXO2/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 11 |
|
|
22.72 |
mg/dl |
0.93 |
3.08 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97296 |
1858 |
| PXO8-2/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 13 |
|
|
25.3 |
g/kg |
0.2 |
0.72 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97200 |
1858 |
| BXH2/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 18 |
|
|
1.04 |
% |
0.02 |
0.08 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97524 |
1858 |
| PXO8-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 10 |
|
|
62.0 |
mg/dl |
1.3 |
4.11 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97224 |
1858 |
| BluHsd:LE |
serum estradiol level |
vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
blood estradiol amount |
male |
98 days
| 8 |
|
|
290.0 |
pg/ml |
10.0 |
28.28 |
radioimmunoassay |
|
0.0 |
0 |
tritium-based |
|
|
76255 |
1543 |
| PXO4/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 9 |
|
|
13.0 |
mg/100g |
0.8 |
2.4 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97392 |
1858 |
| PXO3-1/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 10 |
|
|
1.01 |
% |
0.04 |
0.13 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97504 |
1858 |
| PXO10/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 12 |
|
|
0.8 |
% |
0.02 |
0.07 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97342 |
1858 |
| PXO6-3/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 10 |
|
|
0.02 |
mg/dl |
0.0 |
0.01 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97345 |
1858 |
| PXO8-2/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 13 |
|
|
0.05 |
mg/dl |
0.01 |
0.04 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97351 |
1858 |
| PXO7-1/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 8 |
|
|
0.02 |
mg/dl |
0.01 |
0.03 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97348 |
1858 |
| PXO3-2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 9 |
|
|
46.2 |
mg/dl |
2.14 |
6.42 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97312 |
1858 |
| BXH2/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 18 |
|
|
30.1 |
mg/dl |
1.7 |
7.21 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97317 |
1858 |
| PXO9/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 9 |
|
|
32.9 |
mg/dl |
2.96 |
8.88 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97303 |
1858 |
| SHR/Izm |
body weight |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
body mass |
male |
91 days-98 days |
10 |
|
|
285.7 |
g |
3.45 |
10.9 |
body weighing method |
|
|
0 |
|
|
|
12487 |
263 |
| WKY/Izm |
serum triglyceride level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood triglyceride amount |
male |
98 days
| 10 |
|
|
11.0 |
mg/dl |
1.08 |
3.4 |
serum triglyceride analysis |
|
|
0 |
|
|
|
12499 |
263 |
| SS/HsdMcwiCrl |
both kidneys wet weight to tibia length ratio |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
kidney mass |
male |
112 days
| 6 |
|
|
0.71 |
g/cm |
0.03 |
0.07 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67642 |
735 |
| SS/HsdMcwiCrl |
water drink intake rate |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
drinking behavior trait |
male |
112 days
| 5 |
|
|
30.1 |
ml/d |
0.8 |
1.79 |
unspecified method |
|
0.0 |
0 |
|
|
|
67666 |
735 |
| SS/HsdMcwiCrl |
urine sodium excretion rate |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
urine sodium amount |
male |
112 days
| 9 |
|
|
6.4 |
mEq/d |
0.4 |
1.2 |
automated urine analysis |
|
0.0 |
0 |
|
|
|
67668 |
735 |
| SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
96.65 |
% |
1.91 |
6.04 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
67672 |
735 |
| WKY/Izm |
adipocyte basal glucose uptake |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte glucose uptake trait |
male |
105 days
| 10 |
|
|
37.9 |
x 1000 cpm/cell |
1.52 |
4.8 |
radioactive glucose uptake assay with liquid scintillation counting |
|
0.0 |
0 |
|
|
|
67926 |
263 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
100.24 |
% |
0.28 |
0.69 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
69618 |
735 |
| SS/HsdMcwiCrl |
urine total protein excretion rate |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
total urine protein amount |
male |
112 days
| 6 |
|
|
0.8 |
mg/d |
0.06 |
0.15 |
bicinchoninic acid protein assay |
|
0.0 |
0 |
|
|
|
69615 |
735 |
| BluHsd:LE |
both testes wet weight |
vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
testis mass |
male |
98 days
| 8 |
|
|
3.4 |
g |
0.2 |
0.57 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
76249 |
1543 |
| BluHsd:LE |
body weight |
controlled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
body mass |
male |
98 days
| 8 |
|
|
486.9 |
g |
8.7 |
24.61 |
body weighing method |
|
0.0 |
0 |
|
|
|
76155 |
1543 |
| BluHsd:LE |
food calorie intake level to change in body weight ratio |
controlled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
12.1 |
kcal/g |
2.1 |
5.94 |
unspecified method |
|
0.0 |
0 |
|
|
|
76186 |
1543 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 5 |
logEC50 |
|
-6.2 |
null |
0.1 |
0.22 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
84644 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
logEC50 |
|
-7.4 |
null |
0.1 |
0.32 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
84641 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
logEC50 |
|
-8.0 |
null |
0.09 |
0.28 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
84649 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
-29.33 |
% |
4.38 |
13.85 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84657 |
735 |
| SS/HsdMcwiCrl |
potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then potassium chloride solution (100 mmol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 10 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
301.44 |
% |
27.24 |
86.14 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
KCl-induced blood vessel constriction expressed as percent of force at baseline |
|
84681 |
735 |
| PXO4/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 9 |
|
|
300.1 |
g |
5.1 |
15.3 |
body weighing method |
|
0.0 |
0 |
|
|
|
97169 |
1858 |
| PXO6-1/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 10 |
|
|
0.09 |
mg/dl |
0.03 |
0.09 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97580 |
1858 |
| PXO3-1/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 10 |
|
|
0.29 |
mg/dl |
0.02 |
0.06 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97583 |
1858 |
| PXO3-2/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 9 |
|
|
0.36 |
mg/dl |
0.09 |
0.27 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97584 |
1858 |
| PXO1/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 11 |
|
|
1.16 |
mg/dl |
0.16 |
0.53 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97594 |
1858 |
| PXO5-1/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 11 |
|
|
2.27 |
mg/dl |
0.4 |
1.33 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97595 |
1858 |
| PXO2/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 11 |
|
|
0.98 |
mg/dl |
0.19 |
0.63 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97592 |
1858 |
| PXO1/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 11 |
|
|
0.78 |
% |
0.05 |
0.17 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97784 |
1858 |
| PXO3-1/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 10 |
|
|
1.28 |
% |
0.07 |
0.22 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97792 |
1858 |
| PXO3-2/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 9 |
|
|
18.5 |
mg/dl |
3.1 |
9.3 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97608 |
1858 |
| PXO5-1/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 11 |
|
|
64.7 |
mg/dl |
6.1 |
20.23 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97615 |
1858 |
| PXO5-2/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 10 |
|
|
66.7 |
mg/dl |
5.8 |
18.34 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97616 |
1858 |
| PXO5-2/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 10 |
|
|
21.96 |
nm |
0.19 |
0.6 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97709 |
1858 |
| PXO9/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 9 |
|
|
12.84 |
nm |
0.05 |
0.15 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97707 |
1858 |
| PXO10/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 12 |
|
|
3.4 |
g/kg |
0.1 |
0.35 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97183 |
1858 |
| PXO8-2/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 13 |
|
|
3.7 |
g/kg |
0.1 |
0.36 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97189 |
1858 |
| PXO8-1/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 10 |
|
|
4.2 |
g/kg |
0.3 |
0.95 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97194 |
1858 |
| PXO9/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 9 |
|
|
21.46 |
nm |
0.08 |
0.24 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97688 |
1858 |
| PXO8-1/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 10 |
|
|
5.6 |
g/kg |
0.04 |
0.13 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97123 |
1858 |
| PXO6-1/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 10 |
|
|
6.0 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97151 |
1858 |
| PXO7-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 8 |
|
|
36.57 |
mg/dl |
0.82 |
2.32 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97305 |
1858 |
| PXO4/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 9 |
|
|
39.5 |
nm |
0.4 |
1.2 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97662 |
1858 |
| PXO8-2/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 13 |
|
|
0.84 |
mg/dl |
0.11 |
0.4 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97590 |
1858 |
| PXO3-1/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 10 |
|
|
1.09 |
% |
0.03 |
0.09 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97525 |
1858 |
| BXH2/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 18 |
|
|
15.3 |
mg/dl |
1.0 |
4.24 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97603 |
1858 |
| PXO1/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 11 |
|
|
25.0 |
mg/dl |
2.8 |
9.29 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97610 |
1858 |
| PXO8-1/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 10 |
|
|
1.3 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97529 |
1858 |
| PXO7-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 8 |
|
|
51.7 |
mg/dl |
1.0 |
2.83 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97213 |
1858 |
| PXO3-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 10 |
|
|
53.7 |
mg/dl |
1.3 |
4.11 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97215 |
1858 |
| PXO7-1/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 8 |
|
|
12.24 |
mg/dl |
0.39 |
1.1 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97286 |
1858 |
| PXO5-2/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 10 |
|
|
17.35 |
mg/dl |
0.72 |
2.28 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97290 |
1858 |
| PXO10/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 12 |
|
|
19.44 |
mg/dl |
0.68 |
2.36 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97291 |
1858 |
| PXO9/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 9 |
|
|
20.88 |
mg/dl |
1.08 |
3.24 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97293 |
1858 |
| PXO8-1/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 10 |
|
|
40.1 |
nm |
0.2 |
0.63 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97665 |
1858 |
| BXH2/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 18 |
|
|
1.3 |
% |
0.03 |
0.13 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97514 |
1858 |
| PXO5-1/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 11 |
|
|
10.45 |
mg/dl |
1.44 |
4.78 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97281 |
1858 |
| PXO5-2/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 10 |
|
|
43.0 |
nm |
0.3 |
0.95 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97675 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 13 |
|
|
21.56 |
mg/dl |
0.61 |
2.2 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97294 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 13 |
|
|
10.2 |
mg/dl |
0.5 |
1.8 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97619 |
1858 |
| PXO3-2/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 9 |
|
|
14.8 |
mg/dl |
0.6 |
1.8 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97624 |
1858 |
| PXO6-2/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 8 |
|
|
21.3 |
mg/dl |
1.1 |
3.11 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97632 |
1858 |
| PXO4/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 9 |
|
|
4.09 |
mg/dl |
0.18 |
0.54 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97646 |
1858 |
| PXO3-2/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 9 |
|
|
1.52 |
mg/dl |
0.16 |
0.48 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97261 |
1858 |
| PXO8-2/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 13 |
|
|
3.68 |
mg/dl |
0.31 |
1.12 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97267 |
1858 |
| BXH2/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 18 |
|
|
4.82 |
mg/dl |
0.67 |
2.84 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97268 |
1858 |
| PXO6-1/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 10 |
|
|
0.01 |
mg/dl |
0.0 |
0.01 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97344 |
1858 |
| PXO3-1/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 10 |
|
|
0.03 |
mg/dl |
0.0 |
0.01 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97349 |
1858 |
| PXO5-1/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 11 |
|
|
0.16 |
mg/dl |
0.04 |
0.13 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97357 |
1858 |
| PXO6-2/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 8 |
|
|
278.6 |
g |
5.2 |
14.71 |
body weighing method |
|
0.0 |
0 |
|
|
|
97165 |
1858 |
| PXO6-3/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
|
|
43.66 |
mg/dl |
1.74 |
5.5 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97308 |
1858 |
| PXO3-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
|
|
41.19 |
mg/dl |
1.06 |
3.35 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97306 |
1858 |
| PXO8-2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 13 |
|
|
45.31 |
mg/dl |
1.29 |
4.65 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97309 |
1858 |
| PXO2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 11 |
|
|
46.23 |
mg/dl |
1.97 |
6.53 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97313 |
1858 |
| PXO10/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 12 |
|
|
42.1 |
nm |
0.3 |
1.04 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97670 |
1858 |
| PXO4/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 9 |
|
|
1.01 |
% |
0.01 |
0.03 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97503 |
1858 |
| PXO10/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 12 |
|
|
27.2 |
g/kg |
0.3 |
1.04 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97207 |
1858 |
| PXO8-1/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 10 |
|
|
15.0 |
mg/100g |
0.8 |
2.53 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97398 |
1858 |
| PXO6-2/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 8 |
|
|
23.7 |
g/kg |
0.3 |
0.85 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97195 |
1858 |
| PXO8-2/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 13 |
|
|
4.34 |
mg/dl |
0.28 |
1.01 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97569 |
1858 |
| PXO1/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 11 |
|
|
26.2 |
g/kg |
0.2 |
0.66 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97205 |
1858 |
| SHRSP/A3NCrl |
body weight |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
body mass |
male |
134 days-141 days |
11 |
|
|
315.0 |
g |
7.0 |
23.22 |
body weighing method |
|
0.0 |
0 |
|
high salt/fat diet HSFD |
|
106958 |
3073 |
| SHRSP/A3NCrl |
body weight |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
body mass |
male |
134 days-141 days |
6 |
|
|
331.0 |
g |
16.0 |
39.19 |
body weighing method |
|
0.0 |
0 |
|
HSFD +0.1 mg/kg/day GSK2181236A |
|
106959 |
3073 |
| SHRSP/A3NCrl |
end-diastolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
0.33 |
ml |
0.02 |
0.07 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106968 |
3073 |
| SHRSP/A3NCrl |
end-diastolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
0.38 |
ml |
0.02 |
0.07 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106970 |
3073 |
| SHRSP/A3NCrl |
cardiac output |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
89.0 |
ml/min |
6.0 |
18.97 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107001 |
3073 |
| SHRSP/A3NCrl |
ejection fraction |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
6 |
|
|
67.0 |
% |
2.0 |
4.9 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107024 |
3073 |
| SHRSP/A3NCrl |
ejection fraction |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
9 |
|
|
69.0 |
% |
2.0 |
6.0 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107026 |
3073 |
| SHRSP/A3NCrl |
stroke volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
234000.0 |
ml |
14000.0 |
44271.89 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107031 |
3073 |
| SHRSP/A3NCrl |
stroke volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
9 |
|
|
245000.0 |
ml |
14000.0 |
42000.0 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107032 |
3073 |
| SHRSP/A3NCrl |
ratio of survivors to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
life span trait |
male |
141 days-148 days |
8 |
|
|
69.0 |
% |
|
|
Kaplan-Meier estimate |
|
0.0 |
0 |
|
|
|
107042 |
3073 |
| SHRSP/A3NCrl |
ratio of survivors to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
life span trait |
male |
141 days-148 days |
8 |
|
|
46.0 |
% |
|
|
Kaplan-Meier estimate |
|
0.0 |
0 |
|
|
|
107043 |
3073 |
| SHRSP/A3NCrl |
mean arterial blood pressure |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
arterial blood pressure trait |
male |
99 days-141 days |
9 |
|
serial mean |
183.0 |
mmHg |
7.0 |
21.0 |
vascular indwelling catheter method |
femoral artery |
432000.0 |
0 |
10 seconds every 5 minutes for 24hr |
high salt high fat diet +8 wk treat group |
baseline and after treatment |
107049 |
3073 |
| SHRSP/A3NCrl |
mean arterial blood pressure |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
arterial blood pressure trait |
male |
99 days-141 days |
9 |
|
serial mean |
175.0 |
mmHg |
1.0 |
3.0 |
vascular indwelling catheter method |
femoral artery |
432000.0 |
0 |
10 seconds every 5 minutes for 24hr |
high salt high fat diet +8 wk treat group |
baseline and after treatment |
107050 |
3073 |
| SHRSP/A3NCrl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
6 |
|
|
0.25 |
10E-7mol/l |
0.07 |
0.17 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
nanoMolar |
|
107085 |
3073 |
| SHRSP/A3NCrl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
9 |
|
|
0.26 |
10E-7mol/l |
0.1 |
0.3 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
nanoMolar |
|
107086 |
3073 |
| SHRSP/A3N |
end-diastolic volume |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) then controlled carvedilol content diet (2400 ppm) (for 42 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
203 days-224 days |
8 |
|
|
1.08 |
ml |
0.07 |
0.2 |
transthoracic echocardiography |
|
0.0 |
0 |
|
hsfd +carvedilol reversal |
|
107134 |
3075 |
| SHRSP/A3NCrl |
carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
4 |
|
|
48.0 |
% |
14.0 |
28.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107297 |
3073 |
| SHRSP/A3NCrl |
concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
9 |
|
|
328.0 |
nmol/l |
41.0 |
123.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107303 |
3073 |
| SHRSP/A3NCrl |
concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
6 |
|
|
460.0 |
nmol/l |
83.0 |
203.31 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107302 |
3073 |
| SHRSP/A3NCrl |
body weight |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
body mass |
male |
161 days-175 days |
8 |
|
|
310.0 |
g |
7.0 |
19.8 |
body weighing method |
|
0.0 |
0 |
|
|
|
107381 |
3083 |
| SHRSP/A3N |
ratio of deaths related to chronic hypertension to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 63 days) and controlled fat content diet (24.5 %) (for 63 days) and vehicle control condition (for 63 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
total life span |
male |
147 days-168 days |
25 |
|
|
95.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of deaths related to chronic hypertension to total study population during a period of time (CMO:0003800) |
|
107518 |
3090 |
| SHRSP/A3N |
urine total protein excretion rate |
controlled sodium chloride content drinking water (1 %) (between 35 and 49 days) and controlled fat content diet (24.5 %) (between 35 and 49 days) and vehicle control condition (between 35 and 49 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
total urine protein amount |
male |
119 days-154 days |
0 |
|
|
127.0 |
mg/d |
13.0 |
|
urine protein analysis |
|
86400.0 |
0 |
|
|
|
107520 |
3090 |
| SHRSP/A3N |
body weight |
controlled sodium chloride content drinking water (1 %) (for 42 days) and controlled fat content diet (24.5 %) (for 42 days) and eprosartan (60 mg/kg/d) (for 42 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
body mass |
male |
126 days-147 days |
0 |
|
|
298.0 |
g |
2.0 |
|
body weighing method |
|
0.0 |
0 |
|
|
|
107528 |
3090 |
| SHRSP/A3N |
kidney weight |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney mass |
male |
126 days-182 days |
0 |
|
|
2.77 |
g |
0.2 |
|
post excision weight measurement |
kidney |
0.0 |
0 |
|
|
|
107532 |
3090 |
| SHRSP/A3N |
kidney weight |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney mass |
male |
126 days-182 days |
0 |
|
|
2.65 |
g |
0.1 |
|
post excision weight measurement |
kidney |
0.0 |
0 |
|
|
|
107531 |
3090 |
| SHRSP/A3N |
kidney total tubule cast count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
|
|
4.0 |
/section |
3.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107556 |
3090 |
| SHRSP/A3N |
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) and controlled enrasentan content diet (1200 ppm) (for 112 days) |
Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. |
total life span |
male |
182 days-210 days |
20 |
|
|
5.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time (CMO:0003810) |
|
107935 |
3100 |
| SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
6 |
|
|
0.05 |
umol/l |
0.01 |
0.02 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
microMolar |
|
107079 |
3073 |
| SHRSP/A3NCrl |
end-systolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
98000.0 |
ml |
10000.0 |
31622.78 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106974 |
3073 |
| SHRSP/A3NCrl |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
heart left ventricle mass |
male |
134 days-141 days |
9 |
|
|
3.06 |
mg/g |
0.07 |
0.21 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
LV mass calculated from 2-D images with area-length method |
|
107038 |
3073 |
| SHRSP/A3NCrl |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
heart left ventricle mass |
male |
134 days-141 days |
10 |
|
|
2.85 |
mg/g |
0.1 |
0.32 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
LV mass calculated from 2-D images with area-length method |
|
107039 |
3073 |
| SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
|
|
6.6 |
/section |
2.3 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of interstitial nephritis |
|
107489 |
3088 |
| SHRSP/A3N |
kidney total tubule cast count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
|
|
21.0 |
/section |
11.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
total tubular casts |
|
107494 |
3088 |
| SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
|
|
1.9 |
/section |
1.3 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of tubular regeneration |
|
107486 |
3088 |
| SHRSP/A3N |
heart rate |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
203 days-224 days |
10 |
|
|
341.0 |
beats/min |
20.0 |
63.25 |
tail cuff plethysmography |
|
0.0 |
0 |
|
high salt high fat diet |
|
107117 |
3075 |
| SHRSP/A3N |
end-systolic volume |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) then controlled carvedilol content diet (2400 ppm) (for 42 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
203 days-224 days |
8 |
|
|
0.36 |
ml |
0.07 |
0.2 |
transthoracic echocardiography |
|
0.0 |
0 |
|
hsfd +carvedilol reversal |
|
107136 |
3075 |
| SHRSP/A3N |
body weight |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
body mass |
male |
203 days-224 days |
10 |
|
|
329.0 |
g |
6.0 |
18.97 |
body weighing method |
|
0.0 |
0 |
|
high salt high fat diet |
|
107104 |
3075 |
| Hsd:SD |
plasma albumin level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood albumin amount |
male |
448 days
| 10 |
|
|
0.41 |
g/l |
0.01 |
0.04 |
automated plasma albumin analysis |
|
0.0 |
0 |
|
|
|
138278 |
3201 |
| SD-Ldlrem1Sage |
plasma albumin level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood albumin amount |
male |
448 days
| 16 |
|
|
0.49 |
g/l |
0.03 |
0.12 |
automated plasma albumin analysis |
|
0.0 |
0 |
|
|
|
138279 |
3201 |
| SD-Ldlrem1 |
plasma total protein level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood total protein amount |
male |
448 days
| 16 |
|
|
243.2 |
mg/ml |
44.4 |
177.6 |
automated plasma total protein analysis |
|
0.0 |
0 |
|
|
|
138284 |
3201 |
| SD-Ldlrem1Sage |
plasma aspartate aminotransferase activity level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood aspartate transaminase amount |
male |
448 days
| 16 |
|
|
249.0 |
U/l |
74.0 |
296.0 |
automated plasma aspartate aminotransferase activity assay |
|
0.0 |
0 |
|
|
|
138292 |
3201 |
| Hsd:SD |
plasma creatine kinase activity level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood creatine kinase amount |
male |
448 days
| 10 |
|
|
996.0 |
U/l |
183.0 |
578.7 |
automated plasma creatine kinase activity assay |
|
0.0 |
0 |
|
CK |
|
138294 |
3201 |
| Hsd:SD |
blood low density lipoprotein particle diameter |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood LDL particle size |
male |
448 days
| 10 |
|
|
22.6 |
nm |
0.1 |
0.32 |
nuclear magnetic resonance spectroscopy |
|
0.0 |
0 |
|
|
|
138336 |
3201 |
| SD-Ldlrem1Sage |
area of atherosclerotic lesion to total artery area ratio |
controlled fat content diet (42 %) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
artery integrity trait |
male |
448 days
| 16 |
|
|
33.0 |
% |
5.0 |
20.0 |
ex vivo microscopy |
|
0.0 |
0 |
|
|
|
138350 |
3201 |
| SD-Ldlrem1Sage |
liver triglyceride level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
liver triglyceride amount |
male |
448 days
| 16 |
|
|
18.77 |
mg/g |
1.74 |
6.96 |
isolated tissue triglyceride measurement test |
|
0.0 |
0 |
|
|
|
138349 |
3201 |
| SD-Ldlrem1Sage |
plasma interleukin-6 level |
controlled fat content diet (42 %) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood interleukin-6 amount |
male |
448 days
| 16 |
|
|
307.0 |
pg/ml |
25.0 |
100.0 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138352 |
3201 |
| Hsd:SD |
blood fibrinogen level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
fibrin formation trait |
male |
448 days
| 10 |
|
|
3.08 |
mg/ml |
0.09 |
0.28 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138312 |
3201 |
| Hsd:SD |
plasma leptin level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood leptin amount |
male |
448 days
| 10 |
|
|
34.72 |
ng/ml |
2.72 |
8.6 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138316 |
3201 |
| SS/HsdMcwiCrl |
body weight to tibia length ratio |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
body mass |
male |
112 days
| 9 |
|
|
98.04 |
g/cm |
2.35 |
7.05 |
body weighing method |
|
0.0 |
0 |
|
|
|
67615 |
735 |
| SD-Ahrem1Sage |
plasma chylomicron and VLDL cholesterol level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood cholesterol amount |
male |
448 days
| 16 |
|
|
1495.0 |
mg/dl |
48.0 |
192.0 |
blood cholesterol analysis |
|
0.0 |
0 |
|
|
|
138466 |
3201 |
| BluHsd:LE |
food intake weight to change in body weight ratio |
controlled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
4.8 |
g/g |
0.2 |
0.57 |
unspecified method |
|
0.0 |
0 |
|
|
|
76185 |
1543 |
| WKY/Izm |
absolute change in adipocyte glucose uptake |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then insulin (50000 pmol/l) (for 1 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte glucose uptake trait |
male |
105 days
| 10 |
|
|
106.6 |
cpm x 1000/cell |
4.33 |
13.7 |
radioactive glucose uptake assay with liquid scintillation counting |
|
0.0 |
0 |
|
|
|
67932 |
263 |
| SHR/Izm |
adipocyte maximal glucose uptake to basal glucose uptake ratio |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then insulin (50000 pmol/l) (for 1 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte glucose uptake trait |
male |
105 days
| 10 |
|
|
2.41 |
null |
0.23 |
0.72 |
radioactive glucose uptake assay with liquid scintillation counting |
|
0.0 |
0 |
|
|
|
67929 |
263 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
-19.03 |
% |
4.01 |
9.82 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
|
|
84656 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 7 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
73.42 |
% |
5.62 |
14.87 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84653 |
735 |
| SS/HsdMcwiCrl |
tibia length |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
tibia length |
male |
112 days
| 6 |
|
|
4.3 |
cm |
0.03 |
0.07 |
unspecified method |
|
0.0 |
0 |
|
|
|
67612 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
logEC50 |
|
-8.08 |
null |
0.11 |
0.27 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
|
|
84668 |
735 |
| SS/HsdMcwiCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 7 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
756.89 |
% |
61.56 |
162.87 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
phenylephrine-induced blood vessel constriction expressed as percent of force at baseline |
|
84676 |
735 |
| PXO7-1/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 8 |
|
|
12.35 |
nm |
0.02 |
0.06 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97694 |
1858 |
| PXO6-2/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 8 |
|
|
0.27 |
mg/dl |
0.09 |
0.25 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97582 |
1858 |
| PXO10/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 13 |
|
|
12.6 |
mg/dl |
2.0 |
7.21 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97601 |
1858 |
| PXO8-2/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 13 |
|
|
36.9 |
mg/dl |
4.0 |
14.42 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97614 |
1858 |
| PXO4/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 9 |
|
|
3.7 |
g/kg |
0.1 |
0.3 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97187 |
1858 |
| PXO6-1/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 10 |
|
|
4.1 |
g/kg |
0.2 |
0.63 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97193 |
1858 |
| PXO6-3/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 10 |
|
|
56.0 |
mg/dl |
1.6 |
5.06 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97217 |
1858 |
| BXH2/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 18 |
|
|
3.7 |
g/kg |
0.2 |
0.85 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97104 |
1858 |
| PXO6-1/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 10 |
|
|
0.9 |
% |
0.03 |
0.09 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97521 |
1858 |
| BXH2/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 18 |
|
|
42.6 |
nm |
0.5 |
2.12 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97673 |
1858 |
| PXO1/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 11 |
|
|
257.2 |
g |
5.2 |
17.25 |
body weighing method |
|
0.0 |
0 |
|
|
|
97163 |
1858 |
| PXO2/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 11 |
|
|
0.17 |
mg/dl |
0.03 |
0.1 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97359 |
1858 |
| PXO10/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 12 |
|
|
22.0 |
mg/dl |
1.47 |
5.09 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97297 |
1858 |
| BXH2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 18 |
|
|
28.01 |
mg/dl |
2.08 |
8.82 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97300 |
1858 |
| PXO6-2/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 8 |
|
|
17.0 |
mg/100g |
0.7 |
1.98 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97405 |
1858 |
| WKY/Izm |
body weight |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then controlled fat content diet (26 %) (for 14 days) and controlled potassium content diet (0.44 %) (for 14 days) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
body mass |
male |
119 days
| 10 |
|
|
325.0 |
g |
5.34 |
16.9 |
body weighing method |
|
|
0 |
|
|
|
12491 |
263 |
| SS/HsdMcwiCrl |
both kidneys wet weight to tibia length ratio |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
kidney mass |
male |
112 days
| 9 |
|
|
0.73 |
g/cm |
0.01 |
0.03 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67641 |
735 |
| SS/HsdMcwiCrl |
food intake rate |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
eating behavior trait |
male |
112 days
| 8 |
|
|
25.2 |
g/d |
1.3 |
3.68 |
unspecified method |
|
0.0 |
0 |
|
|
|
67659 |
735 |
| SS/HsdMcwiCrl |
epididymal fat pad weight to tibia length ratio |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
epididymal fat pad mass |
male |
112 days
| 9 |
|
|
1.33 |
g/cm |
0.07 |
0.21 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67653 |
735 |
| SS/HsdMcwiCrl |
water drink intake rate |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
drinking behavior trait |
male |
112 days
| 9 |
|
|
21.8 |
ml/d |
1.6 |
4.8 |
unspecified method |
|
0.0 |
0 |
|
|
|
67664 |
735 |
| SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
98.54 |
% |
0.51 |
1.25 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
67674 |
735 |
| SS/HsdMcwiCrl |
tibia length |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
tibia length |
male |
112 days
| 7 |
|
|
4.24 |
cm |
0.01 |
0.03 |
unspecified method |
|
0.0 |
0 |
|
|
|
67610 |
735 |
| SHR/Izm |
absolute change in adipocyte glucose uptake |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then insulin (50000 pmol/l) (for 1 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte glucose uptake trait |
male |
105 days
| 10 |
|
|
41.6 |
cpm x 1000/cell |
3.95 |
12.5 |
radioactive glucose uptake assay with liquid scintillation counting |
|
0.0 |
0 |
|
|
|
67931 |
263 |
| SHR/Izm |
absolute change in adipocyte free fatty acid secretion |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then isoproterenol (200 nmol/l) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte free fatty acid secretion trait |
male |
105 days
| 10 |
|
|
5.62 |
pmol/cell |
0.2 |
0.64 |
lipolysis assay measuring free fatty acid release |
|
0.0 |
0 |
|
|
|
67933 |
263 |
| SHR/Izm |
serum free fatty acids level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood free fatty acid amount |
male |
98 days
| 10 |
|
|
0.02 |
mmol/l |
0.0 |
0.01 |
serum free fatty acid analysis |
|
0.0 |
0 |
|
|
|
67921 |
263 |
| SS/HsdMcwiCrl |
urine total protein excretion rate |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
total urine protein amount |
male |
112 days
| 9 |
|
|
1.0 |
mg/d |
0.2 |
0.6 |
bicinchoninic acid protein assay |
|
0.0 |
0 |
|
|
|
69613 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
91.96 |
% |
2.76 |
6.76 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
69622 |
735 |
| BluHsd:LE |
total food calorie intake rate |
controlled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
2955.2 |
kcal/d |
65.0 |
183.85 |
unspecified method |
|
0.0 |
0 |
|
|
|
76184 |
1543 |
| BluHsd:LE |
serum testosterone level |
vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
blood testosterone amount |
male |
98 days
| 8 |
|
|
10.0 |
ng/ml |
1.2 |
3.39 |
radioimmunoassay |
|
0.0 |
0 |
tritium-based |
|
|
76253 |
1543 |
| BluHsd:LE |
body weight gain |
vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
body mass |
male |
71 days-98 days |
8 |
|
|
145.3 |
g |
9.3 |
26.3 |
body weighing method |
|
0.0 |
0 |
|
|
|
76161 |
1543 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 4 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
80.04 |
% |
2.63 |
5.26 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84654 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 4 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
70.84 |
% |
4.18 |
8.36 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
|
|
84652 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 5 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
78.37 |
% |
1.3 |
2.91 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84655 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 4 |
logEC50 |
|
-6.49 |
null |
0.13 |
0.26 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84666 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
-16.62 |
% |
7.27 |
17.81 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84659 |
735 |
| SS/HsdMcwiCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
99.39 |
% |
0.74 |
1.81 |
wire myography |
aorta |
0.0 |
0 |
BCA assay |
|
|
84663 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 5 |
logEC50 |
|
-6.49 |
null |
0.09 |
0.2 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84667 |
735 |
| SS/HsdMcwiCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 6 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
564.27 |
% |
57.82 |
141.63 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
phenylephrine-induced blood vessel constriction expressed as percent of force at baseline |
|
84678 |
735 |
| SS/HsdMcwiCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 10 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
607.58 |
% |
51.55 |
163.02 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
phenylephrine-induced blood vessel constriction expressed as percent of force at baseline |
|
84673 |
735 |
| SS/HsdMcwiCrl |
potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then potassium chloride solution (100 mmol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 7 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
312.35 |
% |
20.21 |
53.47 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
Kcl-induced blood vessel constriction expressed as percent of force at baseline |
|
84680 |
735 |
| PXO9/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 9 |
|
|
245.0 |
g |
6.2 |
18.6 |
body weighing method |
|
0.0 |
0 |
|
|
|
97160 |
1858 |
| PXO5-1/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 11 |
|
|
235.1 |
g |
4.8 |
15.92 |
body weighing method |
|
0.0 |
0 |
|
|
|
97158 |
1858 |
| PXO8-1/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 10 |
|
|
279.1 |
g |
4.2 |
13.28 |
body weighing method |
|
0.0 |
0 |
|
|
|
97166 |
1858 |
| PXO7-1/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 8 |
|
|
0.42 |
mg/dl |
0.12 |
0.34 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97586 |
1858 |
| PXO6-1/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 10 |
|
|
3.34 |
mg/dl |
0.15 |
0.47 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97560 |
1858 |
| PXO2/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 11 |
|
|
4.03 |
mg/dl |
0.19 |
0.63 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97565 |
1858 |
| PXO6-2/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 8 |
|
|
4.12 |
mg/dl |
0.21 |
0.59 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97567 |
1858 |
| PXO7-1/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 8 |
|
|
21.44 |
nm |
0.04 |
0.11 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97687 |
1858 |
| PXO10/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 12 |
|
|
21.49 |
nm |
0.09 |
0.31 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97690 |
1858 |
| PXO8-1/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 10 |
|
|
12.55 |
nm |
0.03 |
0.09 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97698 |
1858 |
| PXO3-2/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 9 |
|
|
3.1 |
g/kg |
0.1 |
0.3 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97180 |
1858 |
| PXO2/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 11 |
|
|
3.9 |
g/kg |
0.1 |
0.33 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97191 |
1858 |
| PXO2/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 11 |
|
|
21.2 |
nm |
0.17 |
0.56 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97685 |
1858 |
| PXO3-1/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 10 |
|
|
20.51 |
nm |
0.12 |
0.38 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97677 |
1858 |
| PXO6-3/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 10 |
|
|
235.6 |
g |
6.8 |
21.5 |
body weighing method |
|
0.0 |
0 |
|
|
|
97159 |
1858 |
| PXO6-1/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 10 |
|
|
251.2 |
g |
5.5 |
17.39 |
body weighing method |
|
0.0 |
0 |
|
|
|
97162 |
1858 |
| PXO5-1/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 11 |
|
|
5.8 |
g/kg |
0.1 |
0.33 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97126 |
1858 |
| PXO8-2/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 13 |
|
|
5.5 |
g/kg |
0.1 |
0.36 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97122 |
1858 |
| PXO9/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 9 |
|
|
24.9 |
g/kg |
0.5 |
1.5 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97198 |
1858 |
| BXH2/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 18 |
|
|
6.3 |
g/kg |
0.1 |
0.42 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97120 |
1858 |
| PXO3-2/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 9 |
|
|
3.4 |
mg/dl |
0.15 |
0.45 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97562 |
1858 |
| PXO7-1/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 8 |
|
|
27.7 |
mg/dl |
3.1 |
8.77 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97612 |
1858 |
| PXO6-2/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 8 |
|
|
0.91 |
% |
0.08 |
0.23 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97499 |
1858 |
| PXO6-2/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 8 |
|
|
0.99 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97502 |
1858 |
| PXO4/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 9 |
|
|
66.5 |
mg/dl |
1.3 |
3.9 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97225 |
1858 |
| PXO5-2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 10 |
|
|
60.6 |
mg/dl |
1.4 |
4.43 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97220 |
1858 |
| PXO9/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 9 |
|
|
60.9 |
mg/dl |
2.0 |
6.0 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97221 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 13 |
|
|
30.6 |
g/kg |
0.3 |
1.08 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97103 |
1858 |
| PXO8-2/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 13 |
|
|
12.0 |
mg/100g |
0.4 |
1.44 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97390 |
1858 |
| PXO8-2/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 13 |
|
|
1.08 |
% |
0.02 |
0.07 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97506 |
1858 |
| PXO5-1/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 11 |
|
|
1.15 |
% |
0.02 |
0.07 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97511 |
1858 |
| PXO3-2/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 9 |
|
|
0.88 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97517 |
1858 |
| PXO6-3/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 10 |
|
|
0.89 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97519 |
1858 |
| PXO5-2/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 10 |
|
|
1.26 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97528 |
1858 |
| PXO6-1/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 10 |
|
|
10.95 |
mg/dl |
0.71 |
2.25 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97283 |
1858 |
| PXO1/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 11 |
|
|
42.6 |
mg/dl |
3.5 |
11.61 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97324 |
1858 |
| PXO4/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 9 |
|
|
53.6 |
mg/dl |
4.3 |
12.9 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97327 |
1858 |
| PXO10/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 12 |
|
|
7.1 |
mg/dl |
0.4 |
1.39 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97617 |
1858 |
| PXO5-1/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 11 |
|
|
16.2 |
mg/dl |
0.6 |
1.99 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97625 |
1858 |
| PXO7-1/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 8 |
|
|
20.0 |
mg/dl |
0.8 |
2.26 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97631 |
1858 |
| PXO6-1/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 10 |
|
|
2.86 |
mg/dl |
0.24 |
0.76 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97635 |
1858 |
| BXH2/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 18 |
|
|
3.07 |
mg/dl |
0.17 |
0.72 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97638 |
1858 |
| PXO8-1/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 10 |
|
|
3.85 |
mg/dl |
0.33 |
1.04 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97645 |
1858 |
| PXO6-2/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 8 |
|
|
3.72 |
mg/dl |
0.13 |
0.37 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97643 |
1858 |
| PXO3-1/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 10 |
|
|
2.26 |
mg/dl |
0.17 |
0.54 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97263 |
1858 |
| PXO2/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 11 |
|
|
0.77 |
% |
0.05 |
0.17 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97341 |
1858 |
| PXO6-2/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 8 |
|
|
0.02 |
mg/dl |
0.01 |
0.03 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97346 |
1858 |
| PXO8-1/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 10 |
|
|
0.06 |
mg/dl |
0.01 |
0.03 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97352 |
1858 |
| PXO10/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 12 |
|
|
0.12 |
mg/dl |
0.02 |
0.07 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97355 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 13 |
|
|
25.67 |
mg/dl |
0.67 |
2.42 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97298 |
1858 |
| PXO6-2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 8 |
|
|
46.13 |
mg/dl |
1.76 |
4.98 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97311 |
1858 |
| PXO8-1/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 10 |
|
|
50.7 |
mg/dl |
3.8 |
12.02 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97325 |
1858 |
| PXO2/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 11 |
|
|
24.8 |
g/kg |
0.3 |
0.99 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97197 |
1858 |
| PXO5-1/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 11 |
|
|
41.5 |
nm |
0.3 |
0.99 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97669 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 13 |
|
|
40.5 |
nm |
0.2 |
0.72 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97667 |
1858 |
| PXO1/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 11 |
|
|
42.2 |
nm |
0.3 |
0.99 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97671 |
1858 |
| SHRSP/A3NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
9 |
|
|
112.0 |
% |
3.0 |
9.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107092 |
3073 |
| SHRSP/A3NCrl |
end-diastolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
6 |
|
|
0.33 |
ml |
0.03 |
0.07 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106967 |
3073 |
| SHRSP/A3NCrl |
cardiac output |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
11 |
|
|
80.0 |
ml/min |
4.0 |
13.27 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106997 |
3073 |
| SHRSP/A3NCrl |
ejection fraction |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
71.0 |
% |
1.0 |
3.16 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107025 |
3073 |
| SHRSP/A3NCrl |
ratio of survivors to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
life span trait |
male |
141 days-148 days |
8 |
|
|
69.0 |
% |
|
|
Kaplan-Meier estimate |
|
0.0 |
0 |
|
|
|
107044 |
3073 |
| SHRSP/A3NCrl |
mean arterial blood pressure |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
arterial blood pressure trait |
male |
99 days-141 days |
9 |
|
serial mean |
192.0 |
mmHg |
10.0 |
30.0 |
vascular indwelling catheter method |
femoral artery |
432000.0 |
0 |
10 seconds every 5 minutes for 24hr |
high salt high fat diet group |
baseline and after treatment |
107048 |
3073 |
| SHRSP/A3N |
heart rate |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
189 days-210 days |
0 |
|
|
254.0 |
beats/min |
10.0 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
|
107129 |
3075 |
| SHRSP/A3NCrl |
carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
9 |
|
|
59.0 |
% |
4.0 |
12.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107298 |
3073 |
| SHRSP/A3NCrl |
systolic blood pressure |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
arterial blood pressure trait |
male |
161 days-175 days |
6 |
|
|
162.0 |
mmHg |
4.0 |
9.8 |
tail cuff plethysmography |
|
0.0 |
0 |
|
|
|
107385 |
3083 |
| SHRSP/A3NCrl |
blood urea nitrogen level |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
blood urea nitrogen amount |
male |
161 days-175 days |
8 |
|
|
16.4 |
mg/dl |
1.1 |
3.11 |
blood urea nitrogen analysis |
|
0.0 |
0 |
|
|
|
107392 |
3083 |
| SHRSP/A3N |
both kidneys wet weight to body weight ratio |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney mass |
male |
126 days-182 days |
0 |
|
|
13.0 |
g/kg |
0.7 |
|
post excision weight measurement |
kidney |
0.0 |
0 |
|
|
|
107535 |
3090 |
| SHRSP/A3N |
both kidneys wet weight to body weight ratio |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney mass |
male |
126 days-182 days |
0 |
|
|
8.8 |
g/kg |
0.4 |
|
post excision weight measurement |
kidney |
0.0 |
0 |
|
|
|
107536 |
3090 |
| SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney glomerulus integrity trait |
male |
126 days-182 days |
0 |
|
|
76.5 |
/section |
7.0 |
|
ex vivo light microscopy with histochemistry |
renal glomerulus |
0.0 |
0 |
|
|
|
107539 |
3090 |
| SHRSP/A3N |
plasma aldosterone level |
controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) and controlled enrasentan content diet (2400 ppm) (for 112 days) |
Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. |
blood aldosterone amount |
male |
182 days-210 days |
8 |
|
|
151.0 |
pg/ml |
27.0 |
76.37 |
radioimmunoassay |
|
0.0 |
0 |
|
|
|
107940 |
3100 |
| SHRSP/A3N |
urine total protein excretion rate |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
urine protein amount |
male |
210 days-224 days |
0 |
|
|
251.0 |
mg/d |
120.0 |
|
urine protein analysis |
|
86400.0 |
0 |
metabolic cage; sulfosalicylic acid method |
|
|
107473 |
3088 |
| SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney glomerulus integrity trait |
male |
210 days-224 days |
0 |
|
|
4.0 |
/section |
2.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107478 |
3088 |
| SHRSP/A3N |
systolic blood pressure |
controlled sodium chloride content drinking water (1 %) (for 84 days) and controlled fat content diet (24.5 %) (for 84 days) and vehicle control condition (for 84 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
arterial blood pressure trait |
male |
168 days-189 days |
6 |
|
serial mean |
284.0 |
mmHg |
8.0 |
19.6 |
tail cuff plethysmography |
tail |
0.0 |
0 |
average 3 week intervals for 12 weeks |
|
|
107499 |
3090 |
| SHRSP/A3NCrl |
timed urine volume |
controlled sodium chloride content drinking water (1 %) and controlled fat content diet (24.5 %) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine output |
male |
84 days-91 days |
9 |
|
|
15.0 |
ml/d |
4.0 |
12.0 |
metabolic cage urine volume measurement method |
|
86400.0 |
0 |
baseline |
baseline high salt high fat diet group |
|
107052 |
3073 |
| SHRSP/A3NCrl |
end-systolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
11 |
|
|
102000.0 |
ml |
7000.0 |
23216.37 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106972 |
3073 |
| SHRSP/A3NCrl |
urine albumin excretion rate |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine albumin amount |
male |
84 days-91 days |
9 |
|
|
1.3 |
mg/d |
0.03 |
0.09 |
urine microalbumin analysis |
|
86400.0 |
0 |
baseline |
baseline high salt high fat diet group |
|
107058 |
3073 |
| SHRSP/A3NCrl |
urine sodium excretion rate |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine sodium amount |
male |
99 days-148 days |
9 |
|
|
26.4 |
mEq/d |
2.2 |
6.6 |
urine sodium analysis |
|
86400.0 |
0 |
8 week HSFD |
8 week high salt high fat diet group |
|
107065 |
3073 |
| SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney integrity trait |
male |
126 days-182 days |
0 |
|
|
0.0 |
/section |
0.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
|
107548 |
3090 |
| SHRSP/A3N |
heart rate |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
203 days-224 days |
10 |
|
|
280.0 |
beats/min |
4.0 |
12.65 |
tail cuff plethysmography |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
|
107116 |
3075 |
| SHRSP/A3N |
systolic blood pressure |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
arterial blood pressure trait |
male |
203 days-224 days |
10 |
|
|
260.0 |
mmHg |
6.0 |
18.97 |
tail cuff plethysmography |
tail |
0.0 |
0 |
|
|
|
107095 |
3075 |
| Hsd:SD |
plasma total protein level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood total protein amount |
male |
448 days
| 10 |
|
|
89.7 |
mg/ml |
3.9 |
12.33 |
automated plasma total protein analysis |
|
0.0 |
0 |
|
|
|
138281 |
3201 |
| Hsd:SD |
blood high density lipoprotein particle diameter |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood HDL particle size |
male |
448 days
| 10 |
|
|
11.7 |
nm |
0.4 |
1.26 |
nuclear magnetic resonance spectroscopy |
|
0.0 |
0 |
|
|
|
138340 |
3201 |
| SD-Ahrem1Sage |
plasma high density lipoprotein cholesterol level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood cholesterol amount |
male |
448 days
| 16 |
|
|
81.0 |
mg/dl |
11.0 |
44.0 |
blood cholesterol analysis |
|
0.0 |
0 |
|
|
|
138329 |
3201 |
| SD-Ldlrem1Sage |
blood very low density lipoprotein particle diameter |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood VLDL particle size |
male |
448 days
| 16 |
|
|
68.0 |
nm |
4.0 |
16.0 |
nuclear magnetic resonance spectroscopy |
|
0.0 |
0 |
|
|
|
138333 |
3201 |
| SD-Ldlrem1Sage |
blood interleukin-4 level |
controlled fat content diet (42 %) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood interleukin-4 amount |
male |
448 days
| 16 |
|
|
25.0 |
pg/ml |
3.0 |
12.0 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138362 |
3201 |
| Hsd:SD |
plasma creatinine level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood creatinine amount |
male |
448 days
| 10 |
|
|
0.59 |
mg/dl |
0.03 |
0.09 |
automated plasma creatinine analysis |
|
0.0 |
0 |
|
|
|
138300 |
3201 |
| Hsd:SD |
blood urea nitrogen level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood urea nitrogen amount |
male |
448 days
| 10 |
|
|
16.0 |
mg/dl |
1.0 |
3.16 |
automated blood urea nitrogen analysis |
|
0.0 |
0 |
|
|
|
138304 |
3201 |
| Hsd:SD |
plasma adiponectin level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood adiponectin amount |
male |
448 days
| 10 |
|
|
83.97 |
ug/ml |
5.17 |
16.35 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138320 |
3201 |
| Hsd:SD |
plasma high density lipoprotein cholesterol level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood cholesterol amount |
male |
448 days
| 10 |
|
|
54.0 |
mg/dl |
5.0 |
15.81 |
blood cholesterol analysis |
|
0.0 |
0 |
|
|
|
138328 |
3201 |
| SS/HsdMcwiCrl |
food intake rate |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
eating behavior trait |
male |
112 days
| 9 |
|
|
21.4 |
g/d |
1.1 |
3.3 |
unspecified method |
|
0.0 |
0 |
|
|
|
67660 |
735 |
| Hsd:SD |
plasma chylomicron and VLDL cholesterol level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood cholesterol amount |
male |
448 days
| 10 |
|
|
29.0 |
mg/dl |
6.0 |
18.97 |
blood cholesterol analysis |
|
0.0 |
0 |
|
|
|
138464 |
3201 |
| Hsd:SD |
plasma IDL and LDL cholesterol |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood cholesterol amount |
male |
448 days
| 10 |
|
|
139.0 |
mg/dl |
12.0 |
37.95 |
blood cholesterol analysis |
|
0.0 |
0 |
|
|
|
138465 |
3201 |
| SD-Ahrem1Sage |
plasma IDL and LDL cholesterol |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood cholesterol amount |
male |
448 days
| 16 |
|
|
943.0 |
mg/dl |
85.0 |
340.0 |
blood cholesterol analysis |
|
0.0 |
0 |
|
|
|
138467 |
3201 |
| BluHsd:LE |
food intake weight to change in body weight ratio |
controlled in utero environment (for 9 days) and bisphenol A (25 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
4.7 |
g/g |
0.2 |
0.57 |
unspecified method |
|
0.0 |
0 |
|
|
|
76195 |
1543 |
| BluHsd:LE |
body weight |
vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
body mass |
male |
98 days
| 8 |
|
|
491.1 |
g |
20.4 |
57.7 |
body weighing method |
|
0.0 |
0 |
|
|
|
76148 |
1543 |
| BluHsd:LE |
food calorie intake level to change in body weight ratio |
controlled in utero environment (for 9 days) and bisphenol A (2.5 ug/kg) (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
10.4 |
kcal/g |
0.5 |
1.41 |
unspecified method |
|
0.0 |
0 |
|
|
|
76196 |
1543 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 8 |
logEC50 |
|
-6.3 |
null |
0.2 |
0.57 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
84645 |
735 |
| SS/HsdMcwiCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 5 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
665.33 |
% |
79.91 |
178.68 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
phenylephrine-induced blood vessel constriction expressed as percent of force at baseline |
|
84679 |
735 |
| PXO8-2/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 13 |
|
|
291.4 |
g |
4.8 |
17.31 |
body weighing method |
|
0.0 |
0 |
|
|
|
97167 |
1858 |
| PXO2/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 11 |
|
|
12.76 |
nm |
0.03 |
0.1 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97705 |
1858 |
| PXO4/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 9 |
|
|
0.37 |
mg/dl |
0.1 |
0.3 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97585 |
1858 |
| PXO5-1/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 11 |
|
|
21.21 |
nm |
0.18 |
0.6 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97686 |
1858 |
| PXO8-2/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 13 |
|
|
12.65 |
nm |
0.03 |
0.11 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97701 |
1858 |
| PXO6-2/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 8 |
|
|
5.6 |
g/kg |
0.1 |
0.28 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97124 |
1858 |
| PXO1/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 11 |
|
|
5.9 |
g/kg |
0.1 |
0.33 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97149 |
1858 |
| BXH2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 18 |
|
|
48.7 |
mg/dl |
1.6 |
6.79 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97211 |
1858 |
| BXH2/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 18 |
|
|
15.68 |
mg/dl |
1.08 |
4.58 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97289 |
1858 |
| PXO2/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 11 |
|
|
12.0 |
mg/100g |
1.3 |
4.31 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97389 |
1858 |
| PXO6-1/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 10 |
|
|
1.14 |
% |
0.04 |
0.13 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97510 |
1858 |
| PXO8-1/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 10 |
|
|
3.44 |
mg/dl |
0.25 |
0.79 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97266 |
1858 |
| PXO4/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 9 |
|
|
43.61 |
mg/dl |
0.92 |
2.76 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97307 |
1858 |
| PXO6-2/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 8 |
|
|
40.6 |
mg/dl |
3.9 |
11.03 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97323 |
1858 |
| SHR/Izm |
body weight |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then controlled fat content diet (26 %) (for 14 days) and controlled potassium content diet (0.44 %) (for 14 days) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
body mass |
male |
119 days
| 10 |
|
|
288.0 |
g |
1.42 |
4.5 |
body weighing method |
|
|
0 |
|
|
|
12449 |
263 |
| SHR/Izm |
serum triglyceride level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood triglyceride amount |
male |
98 days
| 10 |
|
|
10.5 |
mg/dl |
0.66 |
2.1 |
serum triglyceride analysis |
|
|
0 |
|
|
|
12448 |
263 |
| SHR/Izm |
serum total cholesterol level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (for 70 days) then fasting |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood cholesterol amount |
male |
98 days
| 10 |
|
|
49.5 |
mg/dl |
2.12 |
6.7 |
serum total cholesterol measurement test |
|
|
0 |
|
|
|
12447 |
263 |
| WKY/Izm |
body weight |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
body mass |
male |
91 days-98 days |
10 |
|
|
318.0 |
g |
3.76 |
11.9 |
body weighing method |
|
|
0 |
|
|
|
12430 |
263 |
| SS/HsdMcwiCrl |
body weight to tibia length ratio |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
body mass |
male |
112 days
| 8 |
|
|
97.84 |
g/cm |
0.03 |
0.08 |
body weighing method |
|
0.0 |
0 |
|
|
|
67617 |
735 |
| SS/HsdMcwiCrl |
heart weight to tibia length ratio |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
heart mass |
male |
112 days
| 7 |
|
|
0.37 |
g/cm |
0.02 |
0.05 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67618 |
735 |
| SS/HsdMcwiCrl |
both kidneys wet weight to tibia length ratio |
controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
kidney mass |
male |
112 days
| 7 |
|
|
0.81 |
g/cm |
0.03 |
0.08 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67639 |
735 |
| SS/HsdMcwiCrl |
urine sodium excretion rate |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
urine sodium amount |
male |
112 days
| 7 |
|
|
9.0 |
mEq/d |
1.3 |
3.44 |
automated urine analysis |
|
0.0 |
0 |
|
|
|
67669 |
735 |
| SS/HsdMcwiCrl |
urine sodium excretion rate |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
urine sodium amount |
male |
112 days
| 4 |
|
|
5.9 |
mEq/d |
0.4 |
0.8 |
automated urine analysis |
|
0.0 |
0 |
|
|
|
67670 |
735 |
| SS/HsdMcwiCrl |
tibia length |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
tibia length |
male |
112 days
| 9 |
|
|
4.26 |
cm |
0.02 |
0.06 |
unspecified method |
|
0.0 |
0 |
|
|
|
67611 |
735 |
| WKY/Izm |
adipocyte maximal glucose uptake to basal glucose uptake ratio |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then insulin (50000 pmol/l) (for 1 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte glucose uptake trait |
male |
105 days
| 10 |
|
|
3.88 |
null |
0.21 |
0.65 |
radioactive glucose uptake assay with liquid scintillation counting |
|
0.0 |
0 |
|
|
|
67930 |
263 |
| WKY/Izm |
serum free fatty acids level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood free fatty acid amount |
male |
98 days
| 10 |
|
|
0.02 |
mmol/l |
0.0 |
0.0 |
serum free fatty acid analysis |
|
0.0 |
0 |
|
|
|
67923 |
263 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
64.5 |
% |
15.34 |
48.51 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
69621 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
logEC50 |
|
-6.6 |
null |
0.1 |
0.24 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
84646 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 7 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
-12.94 |
% |
4.38 |
11.59 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84658 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 4 |
logEC50 |
|
-7.1 |
null |
0.1 |
0.2 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
logEC50 |
|
84640 |
735 |
| SS/HsdMcwiCrl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 7 |
logEC50 |
|
-8.37 |
null |
0.13 |
0.34 |
wire myography |
aorta |
0.0 |
0 |
|
|
|
84670 |
735 |
| SS/HsdMcwiCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (31.6 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasoconstriction trait |
male |
112 days
| 6 |
[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100 |
|
641.52 |
% |
62.37 |
152.77 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
phenylephrine-induced blood vessel constriction expressed as percent of force at baseline |
|
84675 |
735 |
| PXO3-2/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 9 |
|
|
307.6 |
g |
5.8 |
17.4 |
body weighing method |
|
0.0 |
0 |
|
|
|
97171 |
1858 |
| PXO10/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 12 |
|
|
12.73 |
nm |
0.03 |
0.1 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97704 |
1858 |
| PXO6-3/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 10 |
|
|
0.2 |
mg/dl |
0.05 |
0.16 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97581 |
1858 |
| PXO3-1/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 10 |
|
|
3.37 |
mg/dl |
0.21 |
0.66 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97561 |
1858 |
| PXO1/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 11 |
|
|
3.73 |
mg/dl |
0.22 |
0.73 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97563 |
1858 |
| PXO6-3/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 10 |
|
|
0.49 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97781 |
1858 |
| PXO5-1/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 11 |
|
|
0.87 |
% |
0.03 |
0.1 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97789 |
1858 |
| PXO2/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 11 |
|
|
1.12 |
% |
0.05 |
0.17 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97791 |
1858 |
| PXO6-1/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 10 |
|
|
12.12 |
nm |
0.02 |
0.06 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97692 |
1858 |
| PXO1/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 11 |
|
|
12.81 |
nm |
0.02 |
0.07 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97706 |
1858 |
| BXH2/Cub |
body weight |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
body mass |
male |
127 days
| 18 |
|
|
194.0 |
g |
3.0 |
12.73 |
body weighing method |
|
0.0 |
0 |
|
|
|
97100 |
1858 |
| PXO3-1/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 10 |
|
|
3.7 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97188 |
1858 |
| PXO5-1/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 11 |
|
|
3.7 |
g/kg |
0.1 |
0.33 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97186 |
1858 |
| PXO4/Cub |
blood high density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL particle size |
male |
127 days
| 9 |
|
|
12.7 |
nm |
0.02 |
0.06 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97702 |
1858 |
| PXO8-1/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 10 |
|
|
21.07 |
nm |
0.1 |
0.32 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97682 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 13 |
|
|
6.2 |
g/kg |
0.1 |
0.36 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97121 |
1858 |
| PXO2/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 11 |
|
|
5.7 |
g/kg |
0.1 |
0.33 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97125 |
1858 |
| PXO4/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 9 |
|
|
6.3 |
g/kg |
0.1 |
0.3 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97153 |
1858 |
| BXH2/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 18 |
|
|
0.41 |
% |
0.03 |
0.13 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97777 |
1858 |
| PXO3-2/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 9 |
|
|
39.5 |
nm |
0.3 |
0.9 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97663 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 13 |
|
|
0.97 |
% |
0.01 |
0.04 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97500 |
1858 |
| PXO3-1/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 10 |
|
|
16.5 |
mg/dl |
1.0 |
3.16 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97606 |
1858 |
| PXO9/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 9 |
|
|
17.4 |
mg/dl |
2.2 |
6.6 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97607 |
1858 |
| PXO6-2/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 8 |
|
|
15.3 |
mg/dl |
2.8 |
7.92 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97604 |
1858 |
| PXO2/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 11 |
|
|
16.5 |
mg/dl |
1.8 |
5.97 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97605 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 13 |
|
|
21.5 |
mg/dl |
2.6 |
9.37 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97609 |
1858 |
| PXO7-1/Cub |
epididymal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
epididymal fat pad mass |
male |
127 days
| 8 |
|
|
0.98 |
% |
0.06 |
0.17 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97523 |
1858 |
| PXO6-1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 10 |
|
|
42.9 |
mg/dl |
1.7 |
5.38 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97210 |
1858 |
| PXO1/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 11 |
|
|
57.4 |
mg/dl |
1.4 |
4.64 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97218 |
1858 |
| BXH2/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 18 |
|
|
25.2 |
g/kg |
0.2 |
0.85 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97102 |
1858 |
| PXO3-1/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 10 |
|
|
14.0 |
mg/100g |
0.5 |
1.58 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97393 |
1858 |
| PXO9/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 9 |
|
|
1.11 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97508 |
1858 |
| PXO2/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 11 |
|
|
42.9 |
nm |
0.4 |
1.33 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97674 |
1858 |
| PXO3-1/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 10 |
|
|
8.0 |
mg/dl |
0.3 |
0.95 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97618 |
1858 |
| PXO9/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 9 |
|
|
10.2 |
mg/dl |
0.9 |
2.7 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97620 |
1858 |
| PXO2/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 11 |
|
|
11.3 |
mg/dl |
0.5 |
1.66 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97622 |
1858 |
| PXO6-3/Cub |
blood low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL triglyceride amount |
male |
127 days
| 10 |
|
|
17.6 |
mg/dl |
0.3 |
0.95 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97629 |
1858 |
| PXO9/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 9 |
|
|
2.87 |
mg/dl |
0.16 |
0.48 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97636 |
1858 |
| PXO2/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 11 |
|
|
3.2 |
mg/dl |
0.27 |
0.9 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97639 |
1858 |
| PXO10/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 12 |
|
|
2.97 |
mg/dl |
0.16 |
0.55 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97637 |
1858 |
| PXO3-2/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 9 |
|
|
3.68 |
mg/dl |
0.4 |
1.2 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97641 |
1858 |
| PXO8-2/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 13 |
|
|
4.19 |
mg/dl |
0.25 |
0.9 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97647 |
1858 |
| PXO6-3/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 10 |
|
|
4.31 |
mg/dl |
0.18 |
0.57 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97648 |
1858 |
| PXO5-1/Cub |
blood high density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL triglyceride amount |
male |
127 days
| 11 |
|
|
5.55 |
mg/dl |
0.48 |
1.59 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97650 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 13 |
|
|
10.0 |
mg/100g |
0.3 |
1.08 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97340 |
1858 |
| PXO6-1/Cub |
retroperitoneal fat pad weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
retroperitoneal fat pad mass |
male |
127 days
| 10 |
|
|
0.35 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97343 |
1858 |
| PXO4/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 9 |
|
|
0.03 |
mg/dl |
0.01 |
0.03 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97350 |
1858 |
| BXH2/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 18 |
|
|
0.16 |
mg/dl |
0.04 |
0.17 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97358 |
1858 |
| PXO6-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
|
|
31.15 |
mg/dl |
1.38 |
4.36 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97301 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 13 |
|
|
35.6 |
mg/dl |
3.3 |
11.9 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97321 |
1858 |
| PXO10/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 13 |
|
|
16.0 |
mg/100g |
0.5 |
1.8 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97400 |
1858 |
| PXO5-2/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 10 |
|
|
19.0 |
mg/100g |
0.4 |
1.26 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97406 |
1858 |
| BXH2/Cub |
both adrenal glands weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
adrenal gland mass |
male |
127 days
| 18 |
|
|
17.0 |
mg/100g |
0.8 |
3.39 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97403 |
1858 |
| PXO6-3/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 10 |
|
|
4.65 |
mg/dl |
0.19 |
0.6 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97572 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 13 |
|
|
4.91 |
mg/dl |
0.23 |
0.83 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97573 |
1858 |
| PXO10/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 12 |
|
|
5.1 |
mg/dl |
0.13 |
0.45 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97574 |
1858 |
| PXO5-1/Cub |
blood glycerol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood glycerol amount |
male |
127 days
| 11 |
|
|
5.45 |
mg/dl |
0.39 |
1.29 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97575 |
1858 |
| PXO7-1/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 8 |
|
|
39.2 |
nm |
0.2 |
0.57 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97660 |
1858 |
| PXO6-2/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 8 |
|
|
39.2 |
nm |
0.2 |
0.57 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97661 |
1858 |
| SHRSP/A3NCrl |
body weight |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
body mass |
male |
134 days-141 days |
10 |
|
|
338.0 |
g |
5.0 |
15.81 |
body weighing method |
|
0.0 |
0 |
|
HSFD +1.0 mg/kg/day GSK2181236A |
|
106962 |
3073 |
| SHRSP/A3NCrl |
end-diastolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
11 |
|
|
0.33 |
ml |
0.02 |
0.05 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106966 |
3073 |
| SHRSP/A3NCrl |
cardiac output |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
6 |
|
|
76.0 |
ml/min |
7.0 |
17.15 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106998 |
3073 |
| SHRSP/A3NCrl |
cardiac output |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
9 |
|
|
86.0 |
ml/min |
6.0 |
18.0 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107000 |
3073 |
| SHRSP/A3NCrl |
ejection fraction |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
10 |
|
|
67.0 |
% |
1.0 |
3.16 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
107027 |
3073 |
| SHRSP/A3NCrl |
mean arterial blood pressure |
controlled sodium chloride content drinking water (1 %) and controlled fat content diet (24.5 %) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
arterial blood pressure trait |
male |
82 days-89 days |
9 |
|
serial mean |
140.0 |
mmHg |
2.0 |
6.0 |
vascular indwelling catheter method |
femoral artery |
432000.0 |
0 |
10 seconds every 5 minutes for 24hr |
baseline high salt high fat diet group |
baseline and after treatment |
107046 |
3073 |
| SHRSP/A3NCrl |
timed urine volume |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine output |
male |
141 days-148 days |
9 |
|
|
111.0 |
ml/d |
21.0 |
63.0 |
metabolic cage urine volume measurement method |
|
86400.0 |
0 |
8 week HSFD |
8 week high salt high fat diet group |
|
107054 |
3073 |
| SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
8 |
|
|
0.07 |
umol/l |
0.01 |
0.03 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
microMolar |
|
107078 |
3073 |
| SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
9 |
|
|
0.05 |
umol/l |
0.01 |
0.02 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
microMolar |
|
107080 |
3073 |
| SHRSP/A3NCrl |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
8 |
|
|
0.16 |
10E-7mol/l |
0.03 |
0.08 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
nanoMolar |
|
107084 |
3073 |
| SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
4 |
|
|
0.05 |
umol/l |
0.01 |
0.02 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
|
|
107081 |
3073 |
| SHRSP/A3NCrl |
carbachol-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
9 |
|
|
67.0 |
% |
6.0 |
18.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107296 |
3073 |
| SHRSP/A3NCrl |
concentration of carbachol at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
9 |
|
|
385.0 |
nmol/l |
89.0 |
267.0 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107305 |
3073 |
| SHRSP/A3NCrl |
body weight |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
body mass |
male |
161 days-175 days |
6 |
|
|
307.0 |
g |
8.0 |
19.6 |
body weighing method |
|
0.0 |
0 |
|
|
|
107382 |
3083 |
| SHRSP/A3NCrl |
creatinine clearance |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then controlled SB-239063 content diet (1200 ppm) (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
glomerular filtration trait |
male |
161 days-175 days |
8 |
|
|
2.0 |
ml/min |
0.2 |
0.57 |
urine creatinine analysis |
|
0.0 |
0 |
|
|
|
107389 |
3083 |
| SHRSP/A3NCrl |
creatinine clearance |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
glomerular filtration trait |
male |
161 days-175 days |
6 |
|
|
2.0 |
ml/min |
0.2 |
0.49 |
urine creatinine analysis |
|
0.0 |
0 |
|
|
|
107388 |
3083 |
| SHRSP/A3N |
systolic blood pressure |
controlled sodium chloride content drinking water (1 %) (for 84 days) and controlled fat content diet (24.5 %) (for 84 days) and eprosartan (60 mg/kg/d) (for 84 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
arterial blood pressure trait |
male |
168 days-189 days |
6 |
|
serial mean |
250.0 |
mmHg |
9.0 |
22.05 |
tail cuff plethysmography |
tail |
0.0 |
0 |
average 3 week intervals for 12 weeks |
|
|
107500 |
3090 |
| SHRSP/A3NCrl |
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
8 |
|
|
83.0 |
% |
10.0 |
28.28 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride (CMO:0003664) |
|
107072 |
3073 |
| SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
9 |
|
|
0.08 |
umol/l |
0.02 |
0.05 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
microMolar |
|
107082 |
3073 |
| SHRSP/A3NCrl |
end-systolic volume |
controlled sodium chloride content drinking water (1 %) (for 49 days) and controlled fat content diet (24.5 %) (for 49 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 42 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
cardiac output trait |
male |
134 days-141 days |
9 |
|
|
111000.0 |
ml |
11000.0 |
33000.0 |
transthoracic echocardiography |
|
0.0 |
0 |
3-5 cardiac cycles |
|
|
106975 |
3073 |
| SHRSP/A3NCrl |
urine albumin excretion rate |
controlled sodium content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine albumin amount |
male |
99 days-148 days |
9 |
|
|
282.4 |
mg/d |
20.2 |
60.6 |
urine microalbumin analysis |
|
86400.0 |
0 |
8 week HSFD |
8 week high salt high fat diet group |
|
107060 |
3073 |
| SHRSP/A3NCrl |
urine sodium excretion rate |
controlled sodium chloride content diet (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine sodium amount |
male |
84 days-91 days |
9 |
|
|
2.4 |
mEq/d |
0.4 |
1.2 |
urine sodium analysis |
|
86400.0 |
0 |
baseline |
baseline high salt high fat diet group |
|
107063 |
3073 |
| SHRSP/A3NCrl |
urine sodium excretion rate |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
urine sodium amount |
male |
99 days-148 days |
9 |
|
|
16.0 |
mEq/d |
2.0 |
6.0 |
urine sodium analysis |
|
86400.0 |
0 |
8 week HSFD plus treatment |
8 week high salt high fat plus treatment |
|
107066 |
3073 |
| SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and eprosartan (60 mg/kg/d) (between 42 and 77 days) |
Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. |
kidney glomerulus integrity trait |
male |
126 days-182 days |
0 |
|
|
1.4 |
/section |
1.0 |
|
ex vivo light microscopy with histochemistry |
renal glomerulus |
0.0 |
0 |
|
|
|
107540 |
3090 |
| SHRSP/A3NCrl |
concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
8 |
|
|
54.0 |
nmol/l |
14.0 |
39.6 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
high salt high fat diet |
|
107307 |
3073 |
| SHRSP/A3NCrl |
BAY 60-4552-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
8 |
|
|
111.0 |
% |
2.0 |
5.66 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107309 |
3073 |
| SHRSP/A3NCrl |
GSK2181236A-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
8 |
|
|
110.0 |
% |
7.0 |
19.8 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107313 |
3073 |
| SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
|
|
6.4 |
/section |
1.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of tubular regeneration |
|
107485 |
3088 |
| SHRSP/A3N |
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
total life span |
male |
203 days-224 days |
20 |
|
|
0.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time (CMO:0003810) |
|
107112 |
3075 |
| SHRSP/A3N |
heart rate |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) then controlled carvedilol content diet (2400 ppm) (for 42 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
203 days-224 days |
8 |
|
|
236.0 |
beats/min |
8.0 |
22.63 |
transthoracic echocardiography |
|
0.0 |
0 |
|
hsfd +carvedilol reversal |
|
107138 |
3075 |
| SHRSP/A3NCrl |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasodilation trait |
male |
141 days-148 days |
6 |
|
|
98.0 |
% |
5.0 |
12.25 |
tissue force analysis utilizing a force transducer |
|
0.0 |
0 |
|
percent reversal of contractile response to 0.3uM phenylephrine |
|
107091 |
3073 |
| SHRSP/A3N |
end-diastolic volume |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
189 days-210 days |
0 |
|
|
0.69 |
ml |
0.05 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet |
|
107122 |
3075 |
| SHRSP/A3N |
end-diastolic volume |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
189 days-210 days |
0 |
|
|
0.96 |
ml |
0.02 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
|
107121 |
3075 |
| SHRSP/A3N |
end-systolic volume |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
189 days-210 days |
0 |
|
|
0.28 |
ml |
0.03 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
|
107125 |
3075 |
| SHRSP/A3NCrl |
ratio of survivors of severe albuminuria to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) |
Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. |
life span trait |
male |
161 days-175 days |
12 |
|
|
50.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of survivors of severe albuminuria to total study population during a period of time (CMO:0003630) |
|
109030 |
3083 |
| Hsd:SD |
plasma alanine aminotransferase activity level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood alanine transaminase amount |
male |
448 days
| 10 |
|
|
28.0 |
U/l |
4.0 |
12.65 |
automated plasma alanine aminotransferase activity assay |
|
0.0 |
0 |
|
|
|
138287 |
3201 |
| SD-Ldlrem1Sage |
blood low density lipoprotein particle diameter |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood LDL particle size |
male |
448 days
| 16 |
|
|
22.9 |
nm |
0.1 |
0.4 |
nuclear magnetic resonance spectroscopy |
|
0.0 |
0 |
|
|
|
138337 |
3201 |
| Hsd:SD |
blood very low density lipoprotein particle diameter |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood VLDL particle size |
male |
448 days
| 10 |
|
|
95.0 |
nm |
7.0 |
22.14 |
nuclear magnetic resonance spectroscopy |
|
0.0 |
0 |
|
|
|
138332 |
3201 |
| SD-Ldlrem1Sage |
plasma creatine kinase activity level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood creatine kinase amount |
male |
448 days
| 16 |
|
|
527.0 |
U/l |
96.0 |
384.0 |
automated plasma creatine kinase activity assay |
|
0.0 |
0 |
|
CK |
|
138296 |
3201 |
| SD-Ldlrem1Sage |
plasma plasminogen activator inhibitor 1 level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood plasminogen activator inhibitor 1 amount |
male |
448 days
| 16 |
|
|
14.15 |
ng/ml |
1.27 |
5.08 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138309 |
3201 |
| SD-Ldlrem1Sage |
blood fibrinogen level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
fibrin formation trait |
male |
448 days
| 16 |
|
|
3.21 |
mg/ml |
0.32 |
1.28 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138313 |
3201 |
| SD-Ldlrem1Sage |
plasma adiponectin level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood adiponectin amount |
male |
448 days
| 16 |
|
|
58.27 |
ug/ml |
7.02 |
28.08 |
enzyme linked immunosorbent assay |
|
0.0 |
0 |
|
|
|
138321 |
3201 |
| SD-Ldlrem1Sage |
plasma free fatty acids level |
controlled fat content diet (42 %) (for 364 days) |
Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442. |
blood free fatty acid amount |
male |
448 days
| 10 |
|
|
2.95 |
mmol/l |
0.63 |
1.99 |
plasma free fatty acid analysis |
|
0.0 |
0 |
|
|
|
138325 |
3201 |
| SS/HsdMcwiCrl |
heart weight to tibia length ratio |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
heart mass |
male |
112 days
| 9 |
|
|
0.34 |
g/cm |
0.01 |
0.03 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67619 |
735 |
| SS/HsdMcwiCrl |
epididymal fat pad weight to tibia length ratio |
controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
epididymal fat pad mass |
male |
112 days
| 6 |
|
|
1.21 |
g/cm |
0.09 |
0.22 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
67654 |
735 |
| WKY/Izm |
serum triglyceride level |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) then controlled fat content diet (26 %) (for 14 days) and controlled potassium content diet (0.44 %) (for 14 days) then fasting (for 16 hours) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
blood triglyceride amount |
male |
113 days
| 10 |
|
|
15.0 |
mg/dl |
1.8 |
5.7 |
serum triglyceride analysis |
|
|
0 |
|
|
|
12508 |
263 |
| BluHsd:LE |
food intake weight to change in body weight ratio |
controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) |
Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. |
eating behavior trait |
male |
71 days-98 days |
8 |
|
|
4.7 |
g/g |
0.2 |
0.57 |
unspecified method |
|
0.0 |
0 |
|
|
|
76197 |
1543 |
| SHR/Izm |
adipocyte basal glucose uptake |
controlled fat content diet (5 %) (for 70 days) and controlled potassium content diet (0.75 %) (for 70 days) |
Watanabe T, et al., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87. |
adipocyte glucose uptake trait |
male |
105 days
| 10 |
|
|
32.7 |
x 1000 cpm/cell |
2.72 |
8.6 |
radioactive glucose uptake assay with liquid scintillation counting |
|
0.0 |
0 |
|
|
|
67925 |
263 |
| SS/HsdMcwiCrl |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 5 |
logEC50 |
|
-8.4 |
null |
0.21 |
0.47 |
wire myography |
mesenteric artery |
0.0 |
0 |
BCA assay |
|
|
84651 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 10 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
99.53 |
% |
0.41 |
1.3 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
69617 |
735 |
| SS/HsdMcwiCrl |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) |
Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26. |
vasodilation trait |
male |
112 days
| 6 |
[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100 |
|
92.95 |
% |
1.46 |
3.58 |
wire myography |
mesenteric artery |
0.0 |
0 |
|
|
|
69623 |
735 |
| BXH2/Cub |
blood chylomicron triglyceride level |
controlled sucrose content diet (70 % of calories) (for 7 days) and controlled protein content diet (19.6 % of calories) (for 7 days) and controlled fat content diet (10.4 % of calories) (for 7 days) then fasting (for 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron triglyceride amount |
male |
127 days
| 18 |
|
|
1.03 |
mg/dl |
0.23 |
0.98 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97593 |
1858 |
| BXH2/Cub |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 18 |
|
|
21.82 |
nm |
0.13 |
0.55 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97691 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL particle size |
male |
127 days
| 13 |
|
|
20.64 |
nm |
0.05 |
0.18 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97678 |
1858 |
| PXO5-2/Cub |
heart weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
heart mass |
male |
127 days
| 10 |
|
|
3.8 |
g/kg |
0.2 |
0.63 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97190 |
1858 |
| PXO3-2/Cub |
both kidneys wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
kidney mass |
male |
127 days
| 9 |
|
|
6.0 |
g/kg |
0.1 |
0.3 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97152 |
1858 |
| PXO5-2/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 10 |
|
|
26.5 |
g/kg |
0.2 |
0.63 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97206 |
1858 |
| PXO3-2/Cub |
blood total cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood cholesterol amount |
male |
127 days
| 9 |
|
|
58.5 |
mg/dl |
2.7 |
8.1 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97219 |
1858 |
| PXO8-2/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 13 |
|
|
11.95 |
mg/dl |
0.24 |
0.87 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97285 |
1858 |
| PXO4/Cub |
blood low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood LDL cholesterol amount |
male |
127 days
| 9 |
|
|
19.47 |
mg/dl |
1.06 |
3.18 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97292 |
1858 |
| PXO6-3/Cub |
both testes wet weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
testis mass |
male |
127 days
| 10 |
|
|
1.08 |
% |
0.02 |
0.06 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97507 |
1858 |
| PXO6-1/Cub |
blood very low density lipoprotein triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL triglyceride amount |
male |
127 days
| 10 |
|
|
5.6 |
mg/dl |
0.6 |
1.9 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97600 |
1858 |
| PXO7-1/Cub |
blood very low density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL cholesterol amount |
male |
127 days
| 8 |
|
|
2.91 |
mg/dl |
0.25 |
0.71 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
change to mg/dl when available |
|
97264 |
1858 |
| SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 13 |
|
|
0.07 |
mg/dl |
0.01 |
0.04 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97353 |
1858 |
| PXO9/Cub |
blood very low density lipoprotein particle diameter |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood VLDL particle size |
male |
127 days
| 9 |
|
|
42.5 |
nm |
0.2 |
0.6 |
high-performance liquid chromatography |
|
0.0 |
0 |
|
|
|
97672 |
1858 |
| PXO1/Cub |
blood chylomicron cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood chylomicron cholesterol amount |
male |
127 days
| 11 |
|
|
0.13 |
mg/dl |
0.02 |
0.07 |
enzymatic cholesterol assay |
|
0.0 |
0 |
|
|
|
97356 |
1858 |
| PXO6-3/Cub |
blood triglyceride level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood triglyceride amount |
male |
127 days
| 10 |
|
|
35.3 |
mg/dl |
1.2 |
3.79 |
enzymatic triglyceride assay |
|
0.0 |
0 |
|
|
|
97320 |
1858 |
| PXO3-1/Cub |
liver weight to body weight ratio |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
liver mass |
male |
127 days
| 10 |
|
|
27.5 |
g/kg |
0.3 |
0.95 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
97209 |
1858 |
| SHRSP/A3N |
plasma proANF 31-67 peptide level |
controlled sodium chloride content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) |
Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. |
blood atrial natriuretic factor amount |
male |
182 days-210 days |
8 |
|
|
441.0 |
pg/ml |
71.0 |
200.82 |
radioimmunoassay |
|
0.0 |
0 |
|
|
|
107942 |
3100 |
