SS-Chr 5BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
male |
80 days-99 days |
6 |
0.68 |
ng/ml/h |
0.33 |
0.8 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52450 |
482 |
SS-Chr 5BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
11 |
1.11 |
g/mg |
0.14 |
0.46 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57336 |
522 |
SS-Chr 5BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
8 |
0.8 |
g/mg |
0.1 |
0.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57341 |
522 |
SS-Chr 5BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
male |
70 days-84 days |
8 |
270.5 |
g |
8.3 |
23.5 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55188 |
522 |
SS-Chr 5BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
7 |
0.05 |
umol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54913 |
522 |
SS-Chr 5BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
7 |
-7.35 |
null |
0.08 |
0.21 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56112 |
522 |
SS-Chr 5BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
male |
80 days-99 days |
10 |
20.67 |
mEq/d |
1.77 |
5.6 |
flame atomic emission spectrometry |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52746 |
482 |
SS-Chr 5BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
female |
80 days-99 days |
8 |
11.82 |
mg/d |
2.27 |
6.41 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52593 |
482 |
SS-Chr 5BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
male |
80 days-99 days |
10 |
27.89 |
mg/d |
5.0 |
15.81 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52595 |
482 |
SS-Chr 5BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
female |
70 days-84 days |
11 |
188.4 |
g |
5.7 |
18.9 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55184 |
522 |
SS-Chr 5BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
female |
80 days-99 days |
8 |
122.04 |
mmHg |
2.16 |
6.11 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52842 |
482 |
SS-Chr 5BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
male |
80 days-99 days |
7 |
130.42 |
mmHg |
2.59 |
6.85 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52844 |
482 |
SS-Chr 5BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
female |
80 days-99 days |
8 |
1.03 |
mEq/d |
0.09 |
0.27 |
flame atomic emission spectrometry |
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52940 |
482 |
SS-Chr 5BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
male |
80 days-99 days |
10 |
1.33 |
mEq/d |
0.09 |
0.28 |
flame atomic emission spectrometry |
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52942 |
482 |
SS-Chr 5BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
6 |
2.69 |
ml/min |
0.11 |
0.28 |
urine creatinine analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52156 |
482 |
SS-Chr 5BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
female |
80 days-99 days |
7 |
0.44 |
ng/ml/h |
0.08 |
0.2 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52448 |
482 |
SS-Chr 5BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
female |
80 days-99 days |
8 |
396.82 |
beats/min |
6.28 |
17.76 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52644 |
482 |
SS-Chr 5BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
male |
80 days-99 days |
10 |
46.14 |
mg/d |
7.31 |
23.12 |
automated urine total protein analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52695 |
482 |
SS-Chr 5BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
female |
80 days-99 days |
8 |
16.93 |
mEq/d |
1.84 |
5.21 |
flame atomic emission spectrometry |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52744 |
482 |
SS-Chr 5BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
9 |
0.02 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54908 |
522 |
SS-Chr 5BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
87.91 |
% |
3.41 |
11.32 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54782 |
522 |
SS-Chr 5BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
-6.88 |
null |
0.03 |
0.1 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56917 |
522 |
SS-Chr 5BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
-6.87 |
null |
0.08 |
0.24 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56922 |
522 |
SS-Chr 5BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
male |
80 days-99 days |
6 |
0.3 |
mg/dl |
0.02 |
0.04 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52205 |
482 |
SS-Chr 5BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
female |
80 days-99 days |
8 |
56.03 |
mg/d |
10.37 |
29.33 |
automated urine total protein analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52693 |
482 |
SS-Chr 5BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
male |
80 days-99 days |
7 |
368.73 |
beats/min |
6.96 |
18.42 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52646 |
482 |
SS-Chr 5BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
1.52 |
E-7mole |
0.22 |
0.64 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56527 |
522 |
SS-Chr 5BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
1.96 |
ml/min |
0.13 |
0.33 |
urine creatinine analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52154 |
482 |
SS-Chr 5BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
female |
80 days-99 days |
7 |
0.3 |
mg/dl |
0.02 |
0.05 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52203 |
482 |
SS-Chr 5BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
88.13 |
% |
6.08 |
17.19 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54787 |
522 |
SS-Chr 5BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
9 |
-7.81 |
null |
0.09 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56107 |
522 |
SS-Chr 5BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
1.34 |
E-7mole |
0.1 |
0.32 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56522 |
522 |