Phenominer Database Results (258 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.25 mEq/d 0.15 0.43 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51264 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 421.83 beats/min 9.17 22.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51283 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -55.5 beats/min 21.44 52.51 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51302 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -13.16 beats/min 18.71 41.84 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51306 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 32.05 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51338 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -60.48 beats/min 20.94 51.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51352 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 386.26 beats/min 6.07 14.87 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51481 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 33.19 mmHg 3.65 5.16 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51491 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 6.54 mmHg 3.5 7.83 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51498 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -37.54 beats/min 13.84 41.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51501 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -81.81 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51505 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 12.82 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51593 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -0.89 mmHg 3.73 9.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50698 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 28.48 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50720 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 16.23 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51022 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 45.65 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51423 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 29.29 mmHg 4.91 12.03 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50897 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 2.83 mmHg 1.4 4.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50598 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 10 40.38 mg/d 6.82 21.57 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52713 482
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 9 12.51 mEq/d 0.99 2.97 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52760 482
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 1 1.05 ml/min urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51934 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -14.03 beats/min 11.24 27.53 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51977 481
SS-Chr 18BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 9 0.83 mEq/d 0.07 0.2 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52956 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 404.68 beats/min 23.22 56.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50474 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 0.48 mmHg 1.96 4.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51663 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -57.41 beats/min 0.99 1.4 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50338 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -51.54 beats/min 9.58 23.46 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50343 481
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -6.46 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 57406 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 -8.18 null 0.17 0.74 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56148 522
SS-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 63.05 % 4.72 21.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54819 522
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 0.82 E-7mole 0.11 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56563 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 4 40.5 % 1.94 3.87 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57152 522
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -31.8 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50615 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 139.27 mmHg 3.66 10.35 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50638 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 1.66 ml/min 0.1 0.2 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51447 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 4 3.69 mg/d 0.88 1.77 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51563 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -3.2 mmHg 2.21 5.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51133 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 383.32 beats/min 7.64 20.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51243 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 6 11.86 mEq/d 1.63 3.99 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51293 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -37.49 beats/min 6.24 18.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 52047 481
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 0.06 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56263 522
SS-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 65.5 % 4.1 12.96 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55104 522
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -67.69 beats/min 13.34 40.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51689 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 118.02 mmHg 3.47 8.5 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51741 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 8 23.12 mg/d 6.52 18.44 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51753 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 2.35 beats/min 11.45 28.06 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51790 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 14.15 mmHg 3.4 8.34 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51812 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51899 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 105.29 mmHg 2.43 5.43 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51323 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 107.87 mmHg 1.27 2.21 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51327 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 17.99 mmHg 2.07 6.2 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51334 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 2 0.73 ml/min 0.02 0.02 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51451 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 7 3.47 mg/d 0.73 1.92 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51454 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 24.17 mmHg 4.29 10.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50964 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 3 1.67 ng/ml/h 0.55 0.96 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51006 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 4 1.03 ml/min 0.2 0.41 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51055 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 3.5 mmHg 5.0 12.25 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51494 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -92.93 beats/min 17.96 43.99 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51607 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 -18.8 mmHg 3.71 8.29 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50761 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 124.3 mmHg 1.8 4.42 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50793 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 4 112.87 mmHg 3.21 6.41 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50797 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -3.73 mmHg 1.03 2.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50917 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 -6.74 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50929 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -34.31 beats/min 15.69 47.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51197 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -13.98 beats/min 6.5 15.92 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51211 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -96.0 beats/min 16.27 39.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51221 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 141.2 mmHg 2.44 7.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51626 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 440.68 beats/min 19.68 44.01 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50448 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 6 1.5 ml/min 0.11 0.27 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51930 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 5.12 beats/min 20.66 46.2 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51981 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 17.97 mg/d 3.01 9.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52609 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 10 406.58 beats/min 6.69 21.14 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52664 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 401.2 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50525 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 8 1.26 ml/min 0.18 0.5 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52174 482
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.33 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52223 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 444.41 beats/min 19.19 27.14 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50669 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 119.36 mmHg 4.72 11.57 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50672 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 115.54 mmHg 2.1 4.7 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50676 481
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 21 1.14 g/mg 0.05 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57373 522
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -6.46 null 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 57401 522
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.06 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56258 522
SS-Chr 18BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 99.4 % 0.6 1.9 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56317 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 21 -8.22 null 0.14 0.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56144 522
SS-Chr 18BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56192 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 27.86 % 4.61 12.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54847 522
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 0.02 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54949 522
SS-Chr 18BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -8.05 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56034 522
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 0.91 E-7mole 0.08 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56559 522
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 -7.08 null 0.04 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56954 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 29.14 % 4.0 10.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56713 522
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.53 g/mg 0.11 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56982 522
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 8.97 mmHg 1.29 2.89 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50844 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 10 8.38 mEq/d 0.48 1.51 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52764 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 429.89 beats/min 16.83 50.48 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50521 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 129.04 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51630 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 7 26.06 mg/d 2.21 5.85 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51552 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -23.6 beats/min 13.04 31.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50359 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 -1.93 mmHg 2.59 6.35 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50430 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -98.78 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51693 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -115.34 beats/min 17.44 42.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51707 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -43.88 beats/min 13.58 33.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51721 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 24.22 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51771 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 7 1.73 ml/min 0.16 0.42 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51796 481
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 33.1 % 6.52 20.6 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55085 522
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 3 0.84 ng/ml/h 0.08 0.14 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51836 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -42.21 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51850 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 12.61 mEq/d 0.77 2.17 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51885 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 14.06 mmHg 2.07 2.92 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51738 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 131.22 mmHg 4.62 11.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50942 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -6.56 beats/min 8.43 18.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50980 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 6 1.16 mEq/d 0.25 0.62 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51044 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 1.42 mmHg 1.42 2.0 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51083 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 407.56 beats/min 12.77 38.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51112 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 18.38 mmHg 3.39 8.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51187 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -22.91 beats/min 7.09 10.03 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51214 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 120.15 mmHg 2.48 6.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50737 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 45.19 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50751 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -1.42 mmHg 2.23 5.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50778 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 37.27 mmHg 5.13 11.48 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50788 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 4 5.22 mEq/d 2.07 4.13 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51297 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 394.09 beats/min 7.89 17.63 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51379 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 10.88 beats/min 6.24 13.95 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50904 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -39.28 beats/min 14.49 32.41 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51408 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 4 19.43 mg/d 3.2 6.4 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51437 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 8 2.78 mg/d 0.7 1.97 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51469 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 445.12 beats/min 21.94 43.88 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51485 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 28.44 mmHg 4.62 11.33 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51488 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.28 mg/dl 0.06 0.14 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51533 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 5 21.44 mg/d 6.52 14.57 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51556 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 125.83 mmHg 3.49 8.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52088 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 1.04 ng/ml/h 0.18 0.51 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52468 482
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 2 1.29 ng/ml/h 0.49 0.69 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50569 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -20.32 beats/min 34.38 84.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50586 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -32.32 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50421 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.26 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51647 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 451.67 beats/min 18.13 44.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50327 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 6.33 mmHg 2.64 6.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50369 481
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 20 1.56 g/mg 0.11 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57377 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.03 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55718 522
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.2 10E-7mol/l 0.03 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56242 522
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -60.45 beats/min 16.96 50.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50716 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 0.3 ng/ml/h 0.03 0.07 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50535 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 398.3 beats/min 7.53 18.44 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50666 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 8 0.7 ng/ml/h 0.15 0.42 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50455 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -5.9 beats/min 15.92 38.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51237 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 117.87 mmHg 3.37 7.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52000 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 119.18 mmHg 4.9 12.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51819 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 1 0.35 mg/dl radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51903 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 8 1.75 ml/min 0.2 0.58 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52170 482
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 4.49 mg/d 0.37 1.18 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52613 482
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.1 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56874 522
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 3.98 E-7mole 0.66 2.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54587 522
SS-Chr 18BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -7.73 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56030 522
SS-Chr 18BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 99.7 % 0.3 0.95 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56197 522
SS-Chr 18BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 99.33 % 0.37 1.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56321 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 53.29 % 3.31 8.77 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56437 522
SS-Chr 18BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -8.3 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55488 522
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -2.98 beats/min 11.84 35.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51846 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 3.0 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51866 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 39.28 mmHg 2.49 7.47 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51419 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -31.9 beats/min 13.55 33.19 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51069 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 15.99 beats/min 25.85 57.8 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51073 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 -1.22 mmHg 1.22 2.99 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51080 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 5.49 mmHg 2.01 2.84 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50993 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.35 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51171 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 2 0.37 mg/dl 0.07 0.09 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51537 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 10 32.29 mg/d 10.8 34.17 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51559 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 408.4 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51579 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 -3.43 mmHg 1.25 2.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50804 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 409.57 beats/min 5.76 12.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50881 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 28.03 mmHg 6.24 13.95 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50901 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 1.42 mmHg 2.41 7.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50925 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -1.47 beats/min 34.5 84.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50684 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 29.73 mmHg 2.92 8.76 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50747 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 -6.83 mmHg 2.51 4.35 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50765 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 13.61 mEq/d 0.49 1.38 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 52010 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 91.52 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 52051 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 5 2.8 ng/ml/h 0.87 1.94 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50565 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -47.6 beats/min 14.39 35.25 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50592 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 -21.19 mmHg 2.27 6.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50625 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 114.29 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50642 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 34.17 mmHg 2.14 5.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50656 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 8 407.55 beats/min 8.67 24.52 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52660 482
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -6.63 beats/min 20.93 51.28 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50335 481
SS-Chr 18BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 139.64 % 12.52 33.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17917 381
SS-Chr 18BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 21 329.5 g 4.6 21.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55218 522
SS-Chr 18BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 20 202.7 g 3.1 13.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55222 522
SS-Chr 18BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -8.31 null 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55483 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.01 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55723 522
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 3.86 E-7mole 0.55 1.73 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54592 522
SS-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 67.11 % 4.57 19.37 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54823 522
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.11 umol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56879 522
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 4 0.79 mEq/d 0.09 0.17 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51048 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -57.24 beats/min 12.15 27.17 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51611 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 0.91 mmHg 0.26 0.36 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50433 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 392.07 beats/min 16.4 40.18 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50444 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 15.64 mmHg 2.38 5.84 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51735 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 9 51.57 mg/d 7.55 22.65 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52709 482
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 14.36 mmHg 3.33 7.45 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51816 481
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 51.17 % 3.88 9.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57148 522
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 21 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54945 522
SS-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 59.2 % 2.28 7.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55099 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 48.88 % 3.92 11.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56442 522
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 1 0.67 ng/ml/h radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50539 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -93.61 beats/min 7.41 10.48 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50595 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 15.65 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50602 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -31.24 beats/min 7.66 22.97 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50611 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 10 136.64 mmHg 1.45 4.58 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52862 482
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -30.53 beats/min 12.42 30.42 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51924 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.39 ml/min 0.1 0.23 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51947 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -0.9 mmHg 1.72 4.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51967 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.31 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 52035 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.75 ng/ml/h 0.15 0.45 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52464 482
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -60.38 beats/min 7.16 21.47 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50417 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 20.02 beats/min 10.69 32.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50502 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 2.02 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50506 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -91.71 beats/min 8.29 11.72 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50346 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 115.62 mmHg 3.34 4.72 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51744 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 36.87 mmHg 3.95 11.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51767 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 21.98 mmHg 3.61 10.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51862 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 8.59 mmHg 3.45 8.45 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50990 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 8.14 mmHg 2.01 6.03 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51018 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 7 0.91 mEq/d 0.11 0.28 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51519 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 6 1.92 ml/min 0.12 0.28 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51540 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 384.07 beats/min 7.11 20.11 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51575 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 5.23 mmHg 1.96 5.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51589 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 465.42 beats/min 20.72 35.89 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51383 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -68.33 beats/min 19.97 48.92 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51404 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 10 81.8 mg/d 23.56 74.51 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51433 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 5 1.69 mg/d 0.34 0.75 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51458 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 0.64 mmHg 2.4 5.89 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50840 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 15.12 beats/min 28.47 49.3 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50908 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -9.47 beats/min 6.99 20.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51366 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 89.93 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51370 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 3.43 beats/min 11.16 29.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51086 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 16.96 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51103 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 454.95 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51116 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 41.13 mmHg 2.27 5.57 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50784 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 137.63 mmHg 3.75 11.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51139 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 126.1 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51143 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -31.18 beats/min 16.53 40.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51157 481
SS-Chr 18BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 123.74 % 7.62 22.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17912 381
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.11 10E-7mol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56246 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 5 40.0 % 4.73 10.58 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56289 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 7 39.57 % 3.26 8.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55089 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 26.13 % 3.94 11.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56718 522
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 2.08 g/mg 0.17 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56987 522
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 9.79 mmHg 2.4 7.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51099 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -71.91 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51201 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51313 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 7 2.5 ng/ml/h 0.55 1.46 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50387 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -3.3 beats/min 0.3 0.42 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51793 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 8 134.57 mmHg 2.52 7.13 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52858 482
SS-Chr 18BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 10 0.58 mEq/d 0.04 0.14 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52960 482
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.32 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52219 482
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 -7.14 null 0.05 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56958 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 29.13 % 2.86 8.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54852 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 35.75 % 5.81 16.45 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56285 522