Phenominer Database Results (38 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 13BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 17 1.13 ng/ml/h 0.29 1.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52457 482
SS-Chr 13BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 16 11.92 mEq/d 1.33 5.31 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52757 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84 days-88 days 12 15.9 mg/d 2.1 7.27 urine analysis 86400 0 65203 15
SS-Chr 13BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 16 215.8 g 4.0 15.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55205 522
SS-Chr 13BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 89.5 % 2.32 8.7 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54805 522
SS-Chr 13BN/Mcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89 days 9 162.0 mg/d 24.0 72.0 Bradford protein assay 1.0 0 98686 2138
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 18 143.27 mmHg 0.95 4.05 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52855 482
SS-Chr 13BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54940 522
SS-Chr 13BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 0.87 g/mg 0.1 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57359 522
SS-Chr 13BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 16 1.06 mEq/d 0.09 0.35 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52953 482
SS-Chr 13BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 18 1.39 ml/min 0.09 0.38 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52163 482
SS-Chr 13BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 18 0.35 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52212 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 16 10.59 mg/d 2.08 8.32 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52606 482
SS-Chr 13BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 20 63.79 mg/d 6.53 29.18 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52702 482
SS-Chr 13BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 2.15 E-7mole 0.98 3.66 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56545 522
SS-Chr 13BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.93 E-7mole 0.25 0.75 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56554 522
SS-Chr 13BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 16 75.43 mg/d 8.18 32.71 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52706 482
SS-Chr 13BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.97 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56139 522
SS-Chr 13BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 0.08 umol/l 0.03 0.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54931 522
SS-Chr 13BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 17 408.19 beats/min 2.95 12.16 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52653 482
SS-Chr 13BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 1.0 g/mg 0.07 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57368 522
SS-Chr 13BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 -7.03 null 0.11 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56940 522
SS-Chr 13BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.77 null 0.04 0.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56949 522
SS-Chr 13BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 15 2.38 ml/min 0.23 0.87 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52167 482
SS-Chr 13BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 17 0.33 mg/dl 0.02 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52216 482
SS-Chr 13BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 17 0.43 ng/ml/h 0.09 0.35 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52461 482
SS-Chr 13BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 18 382.3 beats/min 2.75 11.69 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52657 482
SS-Chr 13BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 15 -7.41 null 0.12 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56130 522
SS-Chr 13BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 20 8.83 mEq/d 0.82 3.65 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52753 482
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86 days-89 days 12 142.0 mmHg 1.3 4.5 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 5404 15
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 17 143.21 mmHg 1.44 5.93 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52851 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84 days-88 days 12 21.4 mg/d 3.0 10.39 urine analysis 86400 0 65202 15
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait female 86 days-89 days 12 137.0 mmHg 1.9 6.58 vascular fluid filled catheter left femoral artery 14400 0 on 3 consecutive days 5403 15
SS-Chr 13BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 325.0 g 8.1 25.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55213 522
SS-Chr 13BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 65.63 % 7.7 21.78 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54814 522
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. arterial blood pressure trait male 89 days 8 serial mean 146.0 mmHg 6.0 16.97 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 0 98672 2138
SS-Chr 13BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 20 0.76 mEq/d 0.05 0.24 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52949 482
SS-Chr 13BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 20 5.13 mg/d 0.94 4.22 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52602 482