Phenominer Database Results (32 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 4BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 5 446.87 beats/min 8.17 18.26 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52514 482
FHH-Chr 4BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 9 168.35 mg/d 63.34 190.01 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52127 482
FHH-Chr 4BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 5 0.53 mg/dl 0.04 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52273 482
FHH-Chr 4BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.55 E-7mole 0.56 1.69 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56564 522
FHH-Chr 4BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 5 196.5 mmHg 2.44 5.46 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52561 482
FHH-Chr 4BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.39 g/mg 0.15 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57378 522
FHH-Chr 4BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 1.73 g/mg 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57382 522
FHH-Chr 4BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 78.0 % 4.57 13.7 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54828 522
FHH-Chr 4BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -7.01 null 0.14 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56959 522
FHH-Chr 4BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -7.12 null 0.06 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56963 522
FHH-Chr 4BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.92 null 0.11 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56153 522
FHH-Chr 4BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 5 11.31 mEq/d 3.21 7.18 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52810 482
FHH-Chr 4BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 11.17 ng/ml/h 2.91 8.22 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52911 482
FHH-Chr 4BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 5 465.69 mg/d 116.95 261.51 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52124 482
FHH-Chr 4BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.4 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52276 482
FHH-Chr 4BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 9 0.97 mEq/d 0.1 0.29 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52325 482
FHH-Chr 4BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 9 171.8 g 1.9 5.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55227 522
FHH-Chr 4BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 9 14.41 mEq/d 2.04 6.13 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52813 482
FHH-Chr 4BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.76 null 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56149 522
FHH-Chr 4BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54954 522
FHH-Chr 4BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.81 E-7mole 0.11 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56568 522
FHH-Chr 4BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 5 0.98 ml/min 0.12 0.26 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52369 482
FHH-Chr 4BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 7 1.26 ml/min 0.12 0.31 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52372 482
FHH-Chr 4BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 84.39 mg/d 36.1 108.31 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52419 482
FHH-Chr 4BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 9 165.21 mmHg 10.42 31.27 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52564 482
FHH-Chr 4BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 5 1.12 mEq/d 0.12 0.27 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52322 482
FHH-Chr 4BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 4.38 ng/ml/h 1.19 2.38 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52908 482
FHH-Chr 4BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 227.4 g 3.1 9.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55223 522
FHH-Chr 4BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 86.56 % 6.03 18.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54824 522
FHH-Chr 4BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 5 146.25 mg/d 39.31 87.9 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52416 482
FHH-Chr 4BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 9 444.42 beats/min 7.91 23.74 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52517 482
FHH-Chr 4BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54950 522