Phenominer Database Results (254 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 10 26.17 mmHg 1.75 5.53 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17265 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 151.65 % 13.31 35.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14035 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 112.44 breaths/min 5.18 20.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14808 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.39 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13643 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13648 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 36.26 ml/min 3.77 9.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20703 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 53.73 mmHg 0.9 2.21 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19548 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -47.52 mmHg 1.07 2.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17934 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 51.61 ml/min 4.67 14.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18066 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 467.49 beats/min 17.12 41.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18100 381
SS-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.18 mg/dl 0.24 0.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36638 401
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 13 399.04 beats/min 15.76 56.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17528 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20542 381
SS-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.57 g/dl 0.14 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42247 401
SS-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 18.5 mmol/l 0.68 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42076 401
SS-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 76.22 U/l 5.44 16.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42784 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.08 g/dl 0.08 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39794 401
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.22 mg/kg 0.29 0.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58920 526
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 109.7 % 5.79 15.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54548 381
SS-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 35.44 U/l 3.92 11.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40731 401
SS-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 24 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59564 526
SS-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 29 1.57 g/kg 0.04 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59674 526
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 14 0.29 IU/g 0.07 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47487 461
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 12.74 ml/min/kg 1.11 4.46 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57615 526
SS-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.32 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58127 526
SS-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 22 0.38 null 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58747 526
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 129.71 mmHg 6.81 21.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45746 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 13 11.23 ml/min/g 0.85 3.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46670 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 213.38 beats/min 14.04 34.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45076 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 10.17 IU/g 0.68 1.66 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45113 461
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 119.44 % 5.75 23.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53770 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 292.76 beats/min 77.04 203.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45162 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.25 mmHg 0.16 0.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47374 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 29.89 mmHg 6.0 14.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45284 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 287.03 beats/min 8.89 25.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45869 461
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 37.24 degrees C 0.11 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16589 381
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 14 828.5 s 38.98 145.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49316 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 265.22 beats/min 8.38 25.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47596 461
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 134.12 % 11.39 30.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53729 381
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 131.2 mmHg 7.44 18.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48638 461
SS-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 2.25 g/dl 0.06 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40564 401
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 121.87 breaths/min 5.75 17.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15370 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 110.12 breaths/min 3.55 15.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14811 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 109.6 mmHg 5.05 13.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14665 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.42 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15247 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 117.75 % 4.28 18.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53773 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 110.13 % 7.22 28.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54003 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19813 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.52 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17609 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 115.28 breaths/min 6.83 18.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17687 381
SS-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.82 g/dl 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36976 401
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 40.41 ml/min 2.93 12.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20225 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 118.35 breaths/min 4.53 19.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18282 381
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 73.5 mmHg 2.77 6.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49817 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1071.31 s 63.1 189.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50241 461
SS-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 60.85 fl 0.24 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38762 401
SS-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 4.09 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42250 401
SS-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 8.53 x 10E6 cells/ul 0.36 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39251 401
SS-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 137.44 mmol/l 0.99 2.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39405 401
SS-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.25 mg/dl 0.03 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39590 401
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 107.5 % 6.97 20.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54543 381
SS-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 6 5.88 mmol/l 0.22 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38080 401
SS-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 4.97 mmol/l 0.29 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38083 401
SS-Chr 18BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.05 x 1000 cells/ul 0.02 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41664 401
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.31 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47482 461
SS-Chr 18BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 163.44 mg/dl 3.99 11.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38547 401
SS-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.27 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41885 401
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 12.78 ml/min/kg 1.11 4.01 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57814 526
SS-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 15 42.88 ml/min/kg 2.65 10.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58016 526
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 28.71 mmHg 1.16 2.84 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16446 381
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 37.23 degrees C 0.12 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16586 381
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.46 mg/kg 0.22 0.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58923 526
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 10.89 ml/min/g 0.5 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46667 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.79 mmHg 0.11 0.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47211 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 5.29 ml/min/g 0.49 1.2 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44898 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 57.19 % 4.21 15.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47094 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 84.94 % 4.76 17.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48312 461
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 117.32 % 4.27 18.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53905 381
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.67 degrees C 0.1 0.3 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18228 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17604 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.37 ml 0.02 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15250 381
SS-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 219.0 U/l 21.48 67.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36393 401
SS-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 6.17 g/dl 0.09 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36979 401
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 54.01 % 4.26 12.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47091 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 39.86 % 9.5 26.86 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47169 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 8.02 IU/g 1.87 4.19 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45116 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 44.47 % 10.09 28.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48001 461
SS-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.39 x 1000 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39688 401
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 116.96 % 6.82 20.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54555 381
SS-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.33 mg/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41882 401
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 89.13 mmHg 6.03 22.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49905 461
SS-Chr 18BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.9 g/dl 0.21 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37982 401
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.33 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14903 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17073 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 144.31 % 6.64 19.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14030 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 109.83 % 3.47 14.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54006 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19809 381
SS-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 71.78 mg/dl 2.31 6.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37114 401
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 135.3 breaths/min 8.07 24.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17682 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 51.51 ml/min 2.48 9.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18676 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 44.08 ml/min 2.32 9.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20222 381
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 38.04 degrees C 0.14 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18233 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 115.55 breaths/min 4.5 18.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18279 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 57.54 mmHg 1.58 4.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20500 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 54.09 mmHg 1.49 3.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20504 381
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 61.71 mmHg 4.49 11.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49820 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 14 18.8 % 5.2 19.44 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49715 461
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 55.93 % 0.68 1.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39008 401
SS-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 21.0 mmol/l 0.83 2.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42079 401
SS-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 104.11 mmol/l 0.77 2.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39134 401
SS-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 65.22 U/l 4.86 14.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42787 401
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 125.74 % 3.95 16.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54346 381
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 22 241.7 g 8.0 37.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59076 526
SS-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.11 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39691 401
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 55.54 % 0.67 2.0 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59271 526
SS-Chr 18BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.49 x 1000 cells/ul 0.61 1.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41520 401
SS-Chr 18BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 20.5 mmol/l 0.7 2.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38275 401
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 12.37 % 4.23 11.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48708 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 15 0.84 g 0.06 0.24 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45422 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 26.4 % 7.86 23.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48541 461
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 28.01 mmHg 0.79 2.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16451 381
SS-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 24 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58506 526
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 56.19 % 12.59 35.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45923 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 8 1.67 g 0.07 0.2 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45380 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 8 1.32 g 0.03 0.08 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45383 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 102.5 mmHg 7.71 18.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49155 461
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 0.47 degrees C 0.21 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19577 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -44.02 mmHg 3.33 8.15 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19492 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 236.58 beats/min 11.09 29.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45079 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 130.62 mmHg 6.87 18.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45743 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 5.28 ml/min/g 0.35 0.92 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44901 461
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 15 127.5 g 4.1 16.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49562 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.98 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45419 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 59.08 mmHg 6.11 14.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46431 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 30.19 % 9.52 28.56 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49712 461
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 129.06 % 12.5 33.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54560 381
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 22.89 % 4.38 12.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48711 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.2 IU/g 0.03 0.08 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50089 461
SS-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 29 0.33 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58750 526
SS-Chr 18BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.94 g/dl 0.23 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37985 401
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 %change=VE during 2-3 min hypoxia/control during standard conditions 143.26 % 6.26 25.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13694 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.45 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13937 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.39 ml 0.03 0.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13940 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17077 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 110.0 breaths/min 5.96 15.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15375 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 13 112.35 mmHg 5.55 20.03 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14355 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 9 -6.56 mmHg 0.87 2.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19657 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 139.64 % 12.52 33.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17917 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -45.24 mmHg 2.31 5.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17939 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 46.84 ml/min 4.66 19.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18679 381
SS-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.09 mg/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36641 401
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 -0.24 degrees C 0.16 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20323 381
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 -0.17 degrees C 0.14 0.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20326 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20537 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 -41.66 mmHg 2.98 8.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19488 381
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.19 IU/g 0.03 0.09 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50092 461
SS-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 14 42.14 mmHg 2.7 10.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50014 461
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 55.28 % 0.71 2.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39005 401
SS-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 62.4 fl 0.45 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38759 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.27 pg 0.19 0.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42559 401
SS-Chr 18BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.77 x 1000 cells/ul 0.11 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43238 401
SS-Chr 18BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.5 x 1000 cells/ul 0.07 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43241 401
SS-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.29 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39593 401
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 29 174.0 g 2.5 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59079 526
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 113.69 % 6.36 19.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53543 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 113.35 % 4.12 10.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53548 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 122.03 % 3.76 15.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54343 381
SS-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 46.89 U/l 5.33 15.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40728 401
SS-Chr 18BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 8.02 mg/dl 0.15 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37611 401
SS-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 0.18 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59561 526
SS-Chr 18BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.03 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41661 401
SS-Chr 18BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 17.89 mmol/l 0.79 2.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38278 401
SS-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 55.13 mmHg 3.01 8.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47565 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 276.33 beats/min 8.47 31.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47599 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 121.88 mmHg 7.81 20.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48641 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 62.85 % 13.13 39.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48770 461
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 16.98 ml/min/kg 1.51 6.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57817 526
SS-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 29.79 ml/min/kg 2.69 9.32 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58013 526
SS-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.33 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58130 526
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 9.03 IU/g 1.64 3.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45700 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 53.61 % 8.2 23.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48004 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 232.16 beats/min 11.92 44.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45165 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 56.79 % 10.41 29.44 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47172 461
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 716.67 s 51.79 146.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45385 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 43.71 mmHg 5.28 13.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45245 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 39.34 mmHg 5.65 19.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45287 461
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 53.41 mmHg 0.74 1.95 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19553 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -6.57 mmHg 0.75 1.83 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17711 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 107.22 mmHg 5.67 18.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14359 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 400.39 beats/min 11.33 37.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17532 381
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 172.75 mmHg 9.5 26.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45867 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 14.64 % 5.0 13.23 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47997 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 6 13.93 % 3.29 8.05 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47999 461
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 147.8 g 13.1 39.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49557 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 82.79 mmHg 8.09 21.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49902 461
SS-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 2.08 g/dl 0.06 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40567 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 19.5 pg 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42562 401
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 128.36 mmHg 3.37 8.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14660 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.36 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14898 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 147.4 % 6.9 29.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13697 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 7 29.55 mmHg 1.0 2.64 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17269 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 44.12 ml/min 4.37 13.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20698 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 39.15 ml/min 3.97 10.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18071 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 441.62 beats/min 9.52 25.2 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18105 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 123.74 % 7.62 22.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17912 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -7.24 mmHg 0.7 1.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19661 381
SS-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 78.4 mg/dl 3.29 10.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37111 401
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 105.43 mmHg 6.39 16.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49158 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1094.56 s 28.28 79.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50100 461
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 859.0 s 74.01 222.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49313 461
SS-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 109.7 mmol/l 1.72 5.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39131 401
SS-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 140.33 mmol/l 1.2 3.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39402 401
SS-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 9.19 x 10E6 cells/ul 0.11 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39254 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.47 g/dl 0.12 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39791 401
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 130.0 % 8.87 26.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53724 381
SS-Chr 18BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 16.6 mg/dl 1.06 3.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40842 401
SS-Chr 18BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 22.11 mg/dl 1.05 3.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40845 401
SS-Chr 18BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 5.35 x 1000 cells/ul 0.55 1.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40940 401
SS-Chr 18BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 4.14 x 1000 cells/ul 0.64 1.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40943 401
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 56.21 % 0.67 2.0 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59274 526
SS-Chr 18BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 9.4 mg/dl 0.29 0.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37608 401
SS-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 22 1.27 g/kg 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59671 526
SS-Chr 18BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 4.16 x 1000 cells/ul 0.42 1.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41517 401
SS-Chr 18BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 157.4 mg/dl 7.02 22.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38544 401
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 57.84 mmHg 5.56 19.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46434 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 42.62 % 6.19 23.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48544 461
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 9.59 ml/min/kg 0.78 2.81 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57612 526
SS-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 18 0.05 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58503 526
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 73.4 % 11.09 31.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45926 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.9 ml/min/g 0.57 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44732 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 177.0 mmHg 9.32 26.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45814 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 170.38 mmHg 9.07 25.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45864 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 285.31 beats/min 7.99 22.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45872 461
SS-Chr 18BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 15 6.56 g/kg 0.4 1.55 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45660 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.03 ml/min/g 0.24 0.68 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46633 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 8.16 ml/min/g 0.54 1.42 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46636 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 4.25 mmHg 0.25 0.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47377 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.29 mmHg 0.27 0.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47214 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 85.06 % 26.69 80.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48309 461
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 117.95 % 4.95 19.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53902 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -6.88 mmHg 0.7 1.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17706 381
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.12 degrees C 0.17 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19572 381
SS-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 128.67 U/l 10.36 31.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36396 401
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 29.0 mmHg 9.15 22.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45242 461
SS-Chr 18BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 6.85 g/kg 0.33 0.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45655 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 6.93 IU/g 2.76 6.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45693 461
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 632.96 s 44.45 125.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45388 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 7.4 ml/min/g 1.07 3.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44735 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 175.63 mmHg 9.09 25.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45811 461
SS-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 44.44 mmHg 7.53 22.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50011 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1040.41 s 26.35 74.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50097 461
SS-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 58.5 mmHg 3.49 9.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47562 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 1028.19 s 37.92 141.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50244 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 82.11 % 7.43 27.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48773 461