Phenominer Database Results (148 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 138.12 breaths/min 6.86 21.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14794 381
FHH-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.29 ml 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13919 381
FHH-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 116.26 % 6.75 21.35 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53753 381
FHH-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 99.17 % 4.31 13.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53879 381
FHH-Chr XBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 8 443.25 U/l 22.67 64.13 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36375 401
FHH-Chr XBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 7 4.61 g/dl 0.06 0.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36962 401
FHH-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 47.39 ml/min 3.8 12.01 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18658 381
FHH-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 39.07 ml/min 3.2 10.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18662 381
FHH-Chr XBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 7 9.19 mg/dl 0.27 0.71 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36624 401
FHH-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 161.76 breaths/min 10.0 31.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18261 381
FHH-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 39.64 ml/min 2.39 7.55 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20204 381
FHH-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 93.2 g 5.1 16.0 whole body digital scale Moms and pups used in studies were fed Teklad 49523 461
FHH-Chr XBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 8 56.96 fl 0.16 0.44 automated blood cell counting method Moms and pups used in studies were fed Teklad 38741 401
FHH-Chr XBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 7 21.29 mmol/l 0.68 1.8 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42062 401
FHH-Chr XBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 8 142.88 mmol/l 1.04 2.95 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39384 401
FHH-Chr XBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 7 95.43 U/l 4.02 10.64 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42770 401
FHH-Chr XBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 32.01 g/dl 0.17 0.44 automated blood cell counting method Moms and pups used in studies were fed Teklad 39777 401
FHH-Chr XBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 7 1.1 x 1000 cells/ul 0.23 0.61 automated blood cell counting method Moms and pups used in studies were fed Teklad 43224 401
FHH-Chr XBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 7 1.16 g/dl 0.04 0.11 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40550 401
FHH-Chr XBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 8 106.75 U/l 18.71 52.93 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40710 401
FHH-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 7 51.94 % 0.78 2.08 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59257 526
FHH-Chr XBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 8 9.76 mg/dl 0.4 1.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37590 401
FHH-Chr XBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 7 28.43 mg/dl 1.54 4.08 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40828 401
FHH-Chr XBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 7 6.68 x 1000 cells/ul 0.78 2.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41503 401
FHH-Chr XBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 7 0.07 x 1000 cells/ul 0.02 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41647 401
FHH-Chr XBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 7 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41868 401
FHH-Chr XBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.37 degrees C 0.22 0.69 digital rectal thermometry Moms and pups used in studies were fed Teklad 16572 381
FHH-Chr XBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.44 null 0.02 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58729 526
FHH-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 114.48 mmHg 7.03 19.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45725 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 9.51 ml/min/g 0.72 2.03 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46653 461
FHH-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 50.23 mmHg 4.85 13.71 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46417 461
FHH-Chr XBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 75.18 % 4.88 13.81 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48295 461
FHH-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 41.5 mmHg 3.88 10.26 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45266 461
FHH-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 42.73 mmHg 4.92 13.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45270 461
FHH-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.23 ml 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15233 381
FHH-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 148.17 breaths/min 6.32 19.97 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14790 381
FHH-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 126.49 % 6.74 21.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53747 381
FHH-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 94.33 % 3.25 10.27 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53885 381
FHH-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 91.36 % 5.26 16.62 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53980 381
FHH-Chr XBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 0.14 degrees C 0.16 0.49 digital rectal thermometry Moms and pups used in studies were fed Teklad 20309 381
FHH-Chr XBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 8 1015.0 s 39.65 112.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49295 461
FHH-Chr XBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 8 1074.13 s 35.85 101.39 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49299 461
FHH-Chr XBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 8 25.13 mmHg 2.0 5.67 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49993 461
FHH-Chr XBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 8 9.35 x 10E6 cells/ul 0.37 1.04 automated blood cell counting method Moms and pups used in studies were fed Teklad 39233 401
FHH-Chr XBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 7 8.85 x 10E6 cells/ul 0.18 0.47 automated blood cell counting method Moms and pups used in studies were fed Teklad 39237 401
FHH-Chr XBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 7 0.32 x 1000 cells/ul 0.06 0.16 automated blood cell counting method Moms and pups used in studies were fed Teklad 39674 401
FHH-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 118.9 g 5.8 18.2 whole body digital scale Moms and pups used in studies were fed Teklad 59058 526
FHH-Chr XBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 8 1.2 g/dl 0.05 0.14 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40546 401
FHH-Chr XBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 8 7.0 x 1000 cells/ul 0.53 1.5 automated blood cell counting method Moms and pups used in studies were fed Teklad 40922 401
FHH-Chr XBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 1.62 g/kg 0.04 0.13 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59653 526
FHH-Chr XBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 16.64 g/dl 0.29 0.77 automated blood cell counting method Moms and pups used in studies were fed Teklad 37968 401
FHH-Chr XBN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 7 16.71 mmol/l 0.78 2.06 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38261 401
FHH-Chr XBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 41.86 % 6.66 18.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48527 461
FHH-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 109.41 mmHg 7.01 19.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48620 461
FHH-Chr XBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 54.67 ml/min/kg 10.65 30.11 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57995 526
FHH-Chr XBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 6 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58489 526
FHH-Chr XBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 7.02 g/kg 0.36 1.13 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45625 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 7 4.15 ml/min/g 0.36 0.96 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44714 461
FHH-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 5.31 mmHg 0.27 0.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47197 461
FHH-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 90.4 % 4.08 12.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53986 381
FHH-Chr XBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 7 70.0 mg/dl 2.27 6.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37097 401
FHH-Chr XBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 0.44 degrees C 0.17 0.54 digital rectal thermometry Moms and pups used in studies were fed Teklad 20305 381
FHH-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 97.7 g 5.7 17.9 whole body digital scale Moms and pups used in studies were fed Teklad 49527 461
FHH-Chr XBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 8 7.8 % 2.81 7.96 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49698 461
FHH-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 96.16 mmHg 6.6 17.46 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49884 461
FHH-Chr XBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 7 3.46 g/dl 0.03 0.08 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42233 401
FHH-Chr XBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 7 110.14 mmol/l 0.83 2.19 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39117 401
FHH-Chr XBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 8 18.38 pg 0.08 0.21 automated blood cell counting method Moms and pups used in studies were fed Teklad 42541 401
FHH-Chr XBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 18.81 pg 0.09 0.23 automated blood cell counting method Moms and pups used in studies were fed Teklad 42545 401
FHH-Chr XBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 7 143.43 mmol/l 0.78 2.07 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39388 401
FHH-Chr XBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 7 0.29 mg/dl 0.01 0.04 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39576 401
FHH-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 3.62 mg/kg 0.69 1.83 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58902 526
FHH-Chr XBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 8 31.25 mg/dl 2.47 6.98 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40824 401
FHH-Chr XBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 7 8.16 x 1000 cells/ul 0.99 2.61 automated blood cell counting method Moms and pups used in studies were fed Teklad 40926 401
FHH-Chr XBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 9 1.76 g/kg 0.05 0.14 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59657 526
FHH-Chr XBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 6 4.37 mmol/l 0.22 0.54 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38066 401
FHH-Chr XBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 8 5.37 x 1000 cells/ul 0.5 1.41 automated blood cell counting method Moms and pups used in studies were fed Teklad 41499 401
FHH-Chr XBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 7 162.14 mg/dl 16.16 42.75 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38530 401
FHH-Chr XBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 37.31 % 3.89 10.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48523 461
FHH-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 106.89 mmHg 8.02 22.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48624 461
FHH-Chr XBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 19.66 ml/min/kg 1.75 4.29 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57598 526
FHH-Chr XBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 65.73 ml/min/kg 5.7 13.95 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57999 526
FHH-Chr XBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 7 0.49 null 0.04 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58733 526
FHH-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 5 1.8 mg/kg 0.65 1.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58906 526
FHH-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 160.33 beats/min 11.39 32.21 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45148 461
FHH-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 54.66 mmHg 4.52 11.97 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46413 461
FHH-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 0.27 ml 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15229 381
FHH-Chr XBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 137.36 % 11.61 36.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13676 381
FHH-Chr XBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 125.99 % 8.34 26.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13680 381
FHH-Chr XBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 7 364.29 U/l 11.86 31.39 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36379 401
FHH-Chr XBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 8 4.6 g/dl 0.17 0.48 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36958 401
FHH-Chr XBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 8 75.13 mg/dl 3.17 8.97 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37093 401
FHH-Chr XBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 8 9.31 mg/dl 0.14 0.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36620 401
FHH-Chr XBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 8 9.45 % 2.89 8.17 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49694 461
FHH-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 8 53.23 % 2.09 5.9 automated blood cell counting method Moms and pups used in studies were fed Teklad 38987 401
FHH-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 7 51.94 % 0.78 2.08 automated blood cell counting method Moms and pups used in studies were fed Teklad 38991 401
FHH-Chr XBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 8 116.5 U/l 14.81 41.88 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42766 401
FHH-Chr XBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 8 0.36 x 1000 cells/ul 0.05 0.15 automated blood cell counting method Moms and pups used in studies were fed Teklad 39670 401
FHH-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 10 137.97 % 9.75 30.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54320 381
FHH-Chr XBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 7 86.0 U/l 5.81 15.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40714 401
FHH-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 8 53.23 % 2.09 5.9 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59253 526
FHH-Chr XBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 7 10.0 mg/dl 0.88 2.34 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37594 401
FHH-Chr XBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 8 17.16 g/dl 0.65 1.85 automated blood cell counting method Moms and pups used in studies were fed Teklad 37964 401
FHH-Chr XBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 7 4.9 mmol/l 0.31 0.82 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38062 401
FHH-Chr XBN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 8 18.38 mmol/l 0.32 0.92 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38257 401
FHH-Chr XBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 8 171.63 mg/dl 14.05 39.73 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38526 401
FHH-Chr XBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 8 0.11 mg/dl 0.01 0.04 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41864 401
FHH-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 213.58 beats/min 9.22 26.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47582 461
FHH-Chr XBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 82.07 % 5.61 14.83 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48752 461
FHH-Chr XBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 84.27 % 8.35 23.61 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48756 461
FHH-Chr XBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 13.29 ml/min/kg 1.71 4.53 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57594 526
FHH-Chr XBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 21.88 ml/min/kg 2.9 7.68 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57796 526
FHH-Chr XBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 29.56 ml/min/kg 2.39 5.86 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57800 526
FHH-Chr XBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 0.44 null 0.04 0.11 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58109 526
FHH-Chr XBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 0.46 null 0.05 0.11 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58113 526
FHH-Chr XBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 6.31 g/kg 0.33 1.03 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45621 461
FHH-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 112.2 mmHg 8.09 22.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45729 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 4.2 ml/min/g 0.25 0.71 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44718 461
FHH-Chr XBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 69.7 % 6.84 18.08 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48291 461
FHH-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.25 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13923 381
FHH-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 158.44 breaths/min 6.39 20.22 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18265 381
FHH-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 32.47 ml/min 2.74 8.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20208 381
FHH-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 92.96 mmHg 8.26 23.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49888 461
FHH-Chr XBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 8 27.25 mmHg 2.35 6.65 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49997 461
FHH-Chr XBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 1275.25 s 46.44 131.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50223 461
FHH-Chr XBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 1330.75 s 39.55 111.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50227 461
FHH-Chr XBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 7 58.73 fl 0.49 1.29 automated blood cell counting method Moms and pups used in studies were fed Teklad 38745 401
FHH-Chr XBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 8 19.13 mmol/l 0.97 2.75 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42058 401
FHH-Chr XBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 8 3.4 g/dl 0.13 0.38 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42229 401
FHH-Chr XBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 8 110.5 mmol/l 0.5 1.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39113 401
FHH-Chr XBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 8 0.31 mg/dl 0.01 0.04 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39572 401
FHH-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 134.25 % 8.73 27.6 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54326 381
FHH-Chr XBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 8 32.26 g/dl 0.11 0.31 automated blood cell counting method Moms and pups used in studies were fed Teklad 39773 401
FHH-Chr XBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 8 1.22 x 1000 cells/ul 0.16 0.45 automated blood cell counting method Moms and pups used in studies were fed Teklad 43220 401
FHH-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 107.2 g 7.4 23.6 whole body digital scale Moms and pups used in studies were fed Teklad 59062 526
FHH-Chr XBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.14 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59543 526
FHH-Chr XBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 0.14 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59547 526
FHH-Chr XBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 8 0.06 x 1000 cells/ul 0.03 0.09 automated blood cell counting method Moms and pups used in studies were fed Teklad 41643 401
FHH-Chr XBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 0.58 g 0.04 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45401 461
FHH-Chr XBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.68 g 0.04 0.14 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45405 461
FHH-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 203.47 beats/min 12.82 36.26 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47578 461
FHH-Chr XBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 10 37.54 degrees C 0.26 0.83 digital rectal thermometry Moms and pups used in studies were fed Teklad 16568 381
FHH-Chr XBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 7 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58485 526
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 9.91 ml/min/g 0.77 2.18 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46649 461
FHH-Chr XBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 42.76 % 2.99 7.91 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47073 461
FHH-Chr XBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 45.1 % 2.68 7.57 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47077 461
FHH-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 5.08 mmHg 0.19 0.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47193 461
FHH-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 138.46 beats/min 14.47 38.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45144 461