Phenominer Database Results (152 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 108.96 % 5.76 18.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54039 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 170.83 breaths/min 10.04 31.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18320 381
FHH-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.9 g/dl 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37016 401
FHH-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 65.88 mg/dl 2.87 8.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37151 401
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 37.1 ml/min 3.15 9.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18717 381
FHH-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 5 6.72 % 3.09 6.91 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49751 461
FHH-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 1206.6 s 46.52 104.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50280 461
FHH-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 20.0 mmol/l 1.07 3.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42116 401
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 49.13 % 1.7 4.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39045 401
FHH-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.18 g/dl 0.12 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42297 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.5 pg 0.07 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42599 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.16 pg 0.05 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42609 401
FHH-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 141.88 mmol/l 0.4 1.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39442 401
FHH-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.55 x 1000 cells/ul 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43278 401
FHH-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 53.13 U/l 3.5 9.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40768 401
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 51.36 % 1.44 4.07 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59321 526
FHH-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 10.07 mg/dl 0.45 1.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37648 401
FHH-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 6 9.07 mg/dl 0.3 0.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37658 401
FHH-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.86 x 1000 cells/ul 0.49 1.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41567 401
FHH-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.04 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41711 401
FHH-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41922 401
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.59 IU/g 0.09 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47478 461
FHH-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 49.58 ml/min/kg 4.09 12.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58053 526
FHH-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.56 null 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58797 526
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 102.7 mmHg 13.12 29.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45782 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 10.85 IU/g 1.15 2.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45977 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 4.43 ml/min/g 0.67 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44771 461
FHH-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 71.02 % 17.68 39.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48348 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 35.57 mmHg 6.48 14.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45323 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 35.94 mmHg 6.71 16.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45333 461
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 125.33 breaths/min 6.75 21.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14849 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 120.68 breaths/min 4.64 14.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14859 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 107.61 % 5.07 16.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54049 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.22 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13978 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.22 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13988 381
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 104.34 % 3.74 11.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53816 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 110.72 % 7.4 23.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53948 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 145.46 breaths/min 7.57 23.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18330 381
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 32.04 ml/min 3.04 9.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18727 381
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 25.72 ml/min 1.84 5.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20273 381
FHH-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.15 degrees C 0.04 0.14 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20364 381
FHH-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 5 964.8 s 44.0 98.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49352 461
FHH-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 109.63 mmol/l 0.71 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39171 401
FHH-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.21 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39728 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.59 g/dl 0.25 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39831 401
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.71 mg/kg 0.41 1.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58960 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.32 mg/kg 0.82 2.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58970 526
FHH-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.65 g/dl 0.06 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40604 401
FHH-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 22.88 mg/dl 1.61 4.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40882 401
FHH-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 5.66 x 1000 cells/ul 0.47 1.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40990 401
FHH-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.8 g/kg 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59711 526
FHH-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.67 g/kg 0.09 0.3 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59721 526
FHH-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.63 mmol/l 0.26 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38130 401
FHH-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 6 145.17 mg/dl 4.77 11.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38594 401
FHH-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41932 401
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 0.51 IU/g 0.21 0.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47461 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 221.87 beats/min 11.62 25.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47635 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 97.39 mmHg 13.03 29.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48677 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 85.95 mmHg 10.2 28.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48687 461
FHH-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.49 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58167 526
FHH-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 9 0.6 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58787 526
FHH-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 6 7.58 g/kg 1.12 2.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45632 461
FHH-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 7.76 g/kg 0.49 1.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45651 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 9.52 ml/min/g 0.57 1.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46706 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.47 ml/min/g 0.81 2.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46716 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 5.11 ml/min/g 1.21 3.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44781 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 5.31 mmHg 0.4 0.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47250 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.45 mmHg 0.38 1.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47260 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 150.46 beats/min 36.22 81.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45201 461
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.2 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15288 381
FHH-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 375.88 U/l 26.78 75.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36443 401
FHH-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 68.63 mg/dl 2.95 8.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37161 401
FHH-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 8.95 mg/dl 0.12 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36678 401
FHH-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.1 degrees C 0.03 0.11 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20374 381
FHH-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 18.88 mmol/l 1.48 4.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42126 401
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 51.36 % 1.44 4.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39055 401
FHH-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.2 x 10E6 cells/ul 0.2 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39301 401
FHH-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.31 mg/dl 0.04 0.11 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39640 401
FHH-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.18 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39738 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.58 g/dl 0.39 1.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39841 401
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 9 125.6 g 3.5 10.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59116 526
FHH-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.71 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40614 401
FHH-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 61.38 U/l 7.26 20.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40778 401
FHH-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 25.13 mg/dl 2.76 7.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40892 401
FHH-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 6.5 x 1000 cells/ul 0.54 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40980 401
FHH-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59601 526
FHH-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.25 mmol/l 0.13 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38120 401
FHH-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 19.88 mmol/l 2.38 6.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38325 401
FHH-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.1 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41701 401
FHH-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 44.17 % 12.84 31.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48590 461
FHH-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 90.74 % 5.43 12.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48809 461
FHH-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 87.4 % 20.48 50.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48819 461
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 14.86 ml/min/kg 0.81 2.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57652 526
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 13.05 ml/min/kg 1.84 5.19 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57662 526
FHH-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.11 degrees C 0.1 0.33 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16637 381
FHH-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 44.19 ml/min/kg 4.95 14.0 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58063 526
FHH-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58543 526
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 14.02 IU/g 2.17 6.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45991 461
FHH-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 174.34 % 13.15 41.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13735 381
FHH-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 139.2 % 11.85 37.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13745 381
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 108.37 % 6.65 21.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53806 381
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 24.95 ml/min 2.27 7.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20263 381
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 77.0 g 11.3 33.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49534 461
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 89.1 g 6.4 19.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49553 461
FHH-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 9.16 % 1.79 4.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49761 461
FHH-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 5 29.6 mmHg 6.54 14.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50050 461
FHH-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 17.88 mmHg 2.75 7.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50060 461
FHH-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 56.83 fl 0.37 1.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38799 401
FHH-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.64 x 10E6 cells/ul 0.28 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39291 401
FHH-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.88 mmol/l 1.03 2.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39452 401
FHH-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 85.25 U/l 3.63 10.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42824 401
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 126.53 % 7.54 23.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54389 381
FHH-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59611 526
FHH-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 16.63 mmol/l 0.86 2.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38315 401
FHH-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 6 0.67 g 0.07 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45458 461
FHH-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.69 g 0.06 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45468 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 58.58 mmHg 9.9 22.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46470 461
FHH-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.96 degrees C 0.1 0.33 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16627 381
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 46.79 % 6.82 15.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47130 461
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 49.25 % 8.18 21.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47140 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 149.85 beats/min 16.91 41.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45211 461
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.21 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15298 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 119.67 % 8.12 25.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53938 381
FHH-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 289.75 U/l 15.64 44.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36433 401
FHH-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.89 g/dl 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37026 401
FHH-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.5 mg/dl 0.38 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36688 401
FHH-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 1025.38 s 46.26 130.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49362 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 94.14 mmHg 14.37 32.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49941 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 73.83 mmHg 7.92 19.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49951 461
FHH-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1324.5 s 67.5 190.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50290 461
FHH-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 55.73 fl 0.65 1.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38809 401
FHH-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.25 g/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42287 401
FHH-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 109.0 mmol/l 1.34 3.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39181 401
FHH-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 95.75 U/l 9.61 27.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42834 401
FHH-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.31 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39630 401
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 147.75 % 10.04 31.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54379 381
FHH-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.58 x 1000 cells/ul 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43288 401
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 138.3 g 8.8 27.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59126 526
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 49.13 % 1.7 4.8 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59311 526
FHH-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.0 g/dl 0.51 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38022 401
FHH-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.71 g/dl 0.39 1.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38032 401
FHH-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.64 x 1000 cells/ul 0.48 1.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41557 401
FHH-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 142.63 mg/dl 7.14 20.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38584 401
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 37.89 mmHg 3.82 9.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46480 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 204.56 beats/min 15.67 44.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47645 461
FHH-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 37.34 % 4.74 10.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48580 461
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 23.72 ml/min/kg 1.41 4.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57854 526
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 23.19 ml/min/kg 2.37 6.71 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57864 526
FHH-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.54 null 0.05 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58177 526
FHH-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58553 526
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 91.4 mmHg 10.39 29.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45792 461
FHH-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 80.33 % 11.87 29.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48358 461