SS-Renem1Mcwi-/- |
mean arterial blood pressure |
controlled sodium content diet (4 %) (for 11 days) |
PhysGen Knockout data |
arterial blood pressure trait |
male |
70 days-77 days |
6 |
1/3 systolic pressure + 2/3 diastolic pressure |
|
121.5 |
mmHg |
5.89 |
14.43 |
radiotelemetry |
carotid artery |
|
0 |
- |
66679 |
717 |
SS-Renem1Mcwi-/- |
left kidney wet weight |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
kidney mass |
male |
70 days-77 days |
5 |
|
|
1.89 |
g |
0.14 |
0.31 |
post excision weight measurement |
|
|
0 |
- |
66802 |
717 |
SS-Renem1Mcwi-/- |
heart wet weight |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
heart mass |
male |
70 days-77 days |
5 |
|
|
0.99 |
g |
0.04 |
0.09 |
post excision weight measurement |
|
|
0 |
- |
67046 |
717 |
SS-Renem1Mcwi-/- |
heart rate |
controlled sodium content diet (4 %) (for 13 days) |
PhysGen Knockout data |
heart pumping trait |
male |
70 days-77 days |
5 |
|
|
376.2 |
beats/min |
3.5 |
7.82 |
radiotelemetry |
carotid artery |
|
0 |
- |
66376 |
717 |
SS-Renem1Mcwi-/- |
serum alanine aminotransferase activity level |
controlled sodium content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood alanine transaminase amount |
female |
63 days
| 4 |
|
|
47.5 |
U/l |
1.98 |
3.96 |
automated serum analysis |
|
0.0 |
0 |
|
98360 |
2038 |
SS-Renem1Mcwi-/- |
serum chloride level |
controlled sodium content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood chloride amount |
male |
63 days
| 8 |
|
|
104.0 |
mmol/l |
0.58 |
1.64 |
automated serum electrolyte analysis |
|
0.0 |
0 |
|
98363 |
2038 |
SS-Renem1Mcwi-/- |
body weight |
controlled sodium content diet (0.4 %) (for 49 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
body mass |
female |
70 days
| 4 |
|
|
148.75 |
g |
4.94 |
9.88 |
body weighing method |
|
0.0 |
0 |
|
98294 |
2038 |
SS-Renem1Mcwi-/- |
serum bicarbonate level |
controlled sodium content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood bicarbonate amount |
male |
63 days
| 8 |
|
|
20.88 |
mmol/l |
0.72 |
2.04 |
automated serum bicarbonate test |
|
0.0 |
0 |
|
98369 |
2038 |
SS-Renem1Mcwi-/- |
diastolic blood pressure |
controlled sodium content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
male |
66 days-69 days |
8 |
|
serial mean |
46.44 |
mmHg |
2.34 |
6.62 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98381 |
2038 |
SS-Renem1Mcwi-/- |
urine sodium excretion rate |
controlled sodium content diet (0.4 %) (for 35 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
urine sodium amount |
male |
56 days
| 8 |
|
|
0.46 |
mEq/d |
0.1 |
0.28 |
urine sodium analysis |
|
0.0 |
0 |
|
98327 |
2038 |
SS-Renem1Mcwi-/- |
urine albumin excretion rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
urine albumin amount |
male |
70 days-77 days |
5 |
|
|
143.74 |
mg/d |
55.32 |
123.7 |
automated urine analysis |
|
|
0 |
- |
66924 |
717 |
SS-Renem1Mcwi-/- |
right kidney wet weight |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
kidney mass |
male |
70 days-77 days |
5 |
|
|
1.67 |
g |
0.16 |
0.35 |
post excision weight measurement |
|
|
0 |
- |
66254 |
717 |
SS-Renem1Mcwi-/- |
urine total protein excretion rate |
controlled sodium content diet (0.4 %) (for 35 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
total urine protein amount |
male |
56 days
| 8 |
|
|
7.83 |
mg/d |
0.95 |
2.69 |
urine total protein analysis |
|
0.0 |
0 |
|
98321 |
2038 |
SS-Renem1Mcwi-/- |
urine sodium excretion rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
urine sodium amount |
male |
70 days-77 days |
5 |
|
|
7.06 |
mEq/d |
1.41 |
3.15 |
automated urine analysis |
|
|
0 |
- |
66863 |
717 |
SS-Renem1Mcwi-/- |
heart rate |
controlled sodium content diet (4 %) (for 12 days) |
PhysGen Knockout data |
heart pumping trait |
male |
70 days-77 days |
5 |
|
|
387.8 |
beats/min |
4.92 |
11.01 |
radiotelemetry |
carotid artery |
|
0 |
- |
67106 |
717 |
SS-Renem1Mcwi-/- |
heart weight to body weight ratio |
controlled sodium content diet (0.4 %) (for 49 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
heart mass |
female |
70 days
| 4 |
|
|
3.8 |
g/kg |
0.1 |
0.2 |
digital scale post excision weight measurement |
|
0.0 |
0 |
|
98300 |
2038 |
SS-Renem1Mcwi-/- |
serum alanine aminotransferase activity level |
controlled sodium chloride content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood alanine transaminase amount |
male |
63 days
| 8 |
|
|
53.63 |
U/l |
5.74 |
16.24 |
automated serum analysis |
|
0.0 |
0 |
|
98357 |
2038 |
SS-Renem1Mcwi-/- |
serum chloride level |
controlled sodium content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood chloride amount |
female |
63 days
| 4 |
|
|
107.25 |
mmol/l |
0.87 |
1.74 |
automated serum electrolyte analysis |
|
0.0 |
0 |
|
98366 |
2038 |
SS-Renem1Mcwi-/- |
body weight |
controlled sodium content diet (4 %) (for 10 days) |
PhysGen Knockout data |
body mass |
male |
70 days-77 days |
8 |
|
|
299.2 |
g |
11.5 |
32.5 |
whole body digital scale |
|
|
0 |
- |
66316 |
717 |
SS-Renem1Mcwi-/- |
heart rate |
controlled sodium content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
heart pumping trait |
female |
66 days-69 days |
4 |
|
serial mean |
436.56 |
beats/min |
7.76 |
15.52 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98396 |
2038 |
SS-Renem1Mcwi-/- |
heart weight to body weight ratio |
controlled sodium content diet (0.4 %) (for 49 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
heart mass |
male |
70 days
| 8 |
|
|
3.1 |
g/kg |
0.1 |
0.28 |
digital scale post excision weight measurement |
|
0.0 |
0 |
|
98297 |
2038 |
SS-Renem1Mcwi-/- |
body weight |
controlled sodium content diet (0.4 %) (for 49 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
body mass |
male |
70 days
| 8 |
|
|
220.5 |
g |
10.7 |
30.26 |
body weighing method |
|
0.0 |
0 |
|
98192 |
2038 |
SS-Renem1Mcwi-/- |
single kidney wet weight to body weight ratio |
controlled sodium content diet (0.4 %) (for 49 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
kidney mass |
male |
70 days
| 8 |
|
|
4.6 |
g/kg |
0.3 |
0.85 |
digital scale post excision weight measurement |
|
0.0 |
0 |
|
98303 |
2038 |
SS-Renem1Mcwi-/- |
mean arterial blood pressure |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
arterial blood pressure trait |
male |
70 days-77 days |
5 |
/3 systolic pressure + 2/3 diastolic pressure |
|
126.8 |
mmHg |
11.56 |
25.85 |
radiotelemetry |
carotid artery |
|
0 |
- |
66496 |
717 |
SS-Renem1Mcwi-/- |
timed urine volume |
controlled sodium content diet (0.4 %) (for 35 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
urine output |
male |
56 days
| 8 |
|
|
22.19 |
ml/d |
1.98 |
5.6 |
metabolic cage urine volume measurement method |
|
0.0 |
0 |
|
98315 |
2038 |
SS-Renem1Mcwi-/- |
timed urine volume |
controlled sodium content diet (0.4 %) (for 35 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
urine output |
male |
56 days
| 8 |
|
|
17.38 |
ml/d |
4.75 |
13.44 |
metabolic cage urine volume measurement method |
|
0.0 |
0 |
|
98318 |
2038 |
SS-Renem1Mcwi-/- |
creatinine clearance to total kidney weight ratio |
controlled sodium content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
glomerular filtration trait |
male |
63 days
| 8 |
|
|
0.33 |
ml/min/g |
0.02 |
0.06 |
unspecified method |
|
0.0 |
0 |
|
98351 |
2038 |
SS-Renem1Mcwi-/- |
creatinine clearance to total kidney weight ratio |
controlled sodium content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
glomerular filtration trait |
female |
63 days
| 4 |
|
|
0.3 |
ml/min/g |
0.03 |
0.06 |
unspecified method |
|
0.0 |
0 |
|
98354 |
2038 |
SS-Renem1Mcwi-/- |
diastolic blood pressure |
controlled sodium content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
female |
66 days-69 days |
4 |
|
serial mean |
49.1 |
mmHg |
2.61 |
5.22 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98390 |
2038 |
SS-Renem1Mcwi-/- |
urine creatinine excretion rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
urine creatinine amount |
male |
70 days-77 days |
5 |
|
|
9.4 |
mg/d |
1.14 |
2.56 |
automated urine analysis |
|
|
0 |
- |
66740 |
717 |
SS-Renem1Mcwi-/- |
urine total protein excretion rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
total urine protein amount |
male |
70 days-77 days |
5 |
|
|
224.36 |
mg/d |
87.57 |
195.81 |
automated urine analysis |
|
|
0 |
- |
66557 |
717 |
SS-Renem1Mcwi-/- |
systolic blood pressure |
controlled sodium content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
male |
66 days-69 days |
8 |
|
serial mean |
72.07 |
mmHg |
2.42 |
6.84 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98379 |
2038 |
SS-Renem1Mcwi-/- |
heart rate |
controlled sodium content diet (4 %) (for 11 days) |
PhysGen Knockout data |
heart pumping trait |
male |
70 days-77 days |
6 |
|
|
381.0 |
beats/min |
15.42 |
37.76 |
radiotelemetry |
carotid artery |
|
0 |
- |
67168 |
717 |
SS-Renem1Mcwi-/- |
mean arterial blood pressure |
controlled sodium content diet (4 %) (for 12 days) |
PhysGen Knockout data |
arterial blood pressure trait |
male |
70 days-77 days |
5 |
1/3 systolic pressure + 2/3 diastolic pressure |
|
119.8 |
mmHg |
7.3 |
16.32 |
radiotelemetry |
carotid artery |
|
0 |
- |
66984 |
717 |
SS-Renem1Mcwi-/- |
serum bicarbonate level |
controlled sodium content diet (0.4 %) (for 42 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
blood bicarbonate amount |
female |
63 days
| 4 |
|
|
16.75 |
mmol/l |
1.2 |
2.4 |
automated serum bicarbonate test |
|
0.0 |
0 |
|
98372 |
2038 |
SS-Renem1Mcwi-/- |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
male |
66 days-69 days |
8 |
|
serial mean |
58.36 |
mmHg |
2.38 |
6.73 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98380 |
2038 |
SS-Renem1Mcwi-/- |
mean arterial blood pressure |
controlled sodium content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
female |
66 days-69 days |
4 |
|
serial mean |
61.59 |
mmHg |
2.87 |
5.74 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98389 |
2038 |
SS-Renem1Mcwi-/- |
heart rate |
controlled sodium chloride content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
heart pumping trait |
male |
66 days-69 days |
8 |
|
serial mean |
402.94 |
beats/min |
4.46 |
12.61 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98393 |
2038 |
SS-Renem1Mcwi-/- |
urine total protein excretion rate |
controlled sodium content diet (0.4 %) (for 35 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
total urine protein amount |
female |
56 days
| 4 |
|
|
12.75 |
mg/d |
8.08 |
16.16 |
urine total protein analysis |
|
0.0 |
0 |
|
98324 |
2038 |
SS-Renem1Mcwi-/- |
urine sodium excretion rate |
controlled sodium content diet (0.4 %) (for 35 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
urine sodium amount |
female |
56 days
| 4 |
|
|
0.34 |
mEq/d |
0.14 |
0.28 |
urine sodium analysis |
|
0.0 |
0 |
|
98330 |
2038 |
SS-Renem1Mcwi-/- |
heart rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
heart pumping trait |
male |
70 days-77 days |
5 |
|
|
383.0 |
beats/min |
14.79 |
33.07 |
radiotelemetry |
carotid artery |
|
0 |
- |
66617 |
717 |
SS-Renem1Mcwi-/- |
mean arterial blood pressure |
controlled sodium content diet (4 %) (for 13 days) |
PhysGen Knockout data |
arterial blood pressure trait |
male |
70 days-77 days |
5 |
1/3 systolic pressure + 2/3 diastolic pressure |
|
128.6 |
mmHg |
7.0 |
15.65 |
radiotelemetry |
carotid artery |
|
0 |
- |
66436 |
717 |
SS-Renem1Mcwi-/- |
single kidney wet weight to body weight ratio |
controlled sodium content diet (0.4 %) (for 49 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
kidney mass |
male |
70 days
| 4 |
|
|
5.9 |
g/kg |
0.3 |
0.6 |
digital scale post excision weight measurement |
|
0.0 |
0 |
|
98306 |
2038 |
SS-Renem1Mcwi-/- |
systolic blood pressure |
controlled sodium content diet (0.4 %) (between 66 and 69 days) |
Moreno C, et al., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17. |
arterial blood pressure trait |
male |
66 days-69 days |
4 |
|
serial mean |
76.38 |
mmHg |
2.94 |
5.88 |
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98388 |
2038 |