Phenominer Database Results (404 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 157.12 % 11.7 37.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54243 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 148.59 % 14.22 42.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13702 381
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 131.78 % 14.78 44.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53777 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 108.93 % 6.8 20.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53909 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 114.96 % 6.31 18.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54010 381
SS-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.3 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15255 381
SS-Chr 19BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 123.99 mmHg 7.48 14.97 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15127 381
SS-Chr 19BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.36 degrees C 0.27 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15691 381
SS-Chr 19BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 3 2.44 ml/min 0.21 0.36 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52179 482
SS-Chr 19BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 0.66 ng/ml/h 0.09 0.25 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52475 482
SS-Chr 19BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 10 202.4 g 10.6 33.6 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17839 381
SS-Chr 19BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 1 -3.9 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19671 381
SS-Chr 19BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 1 7.45 null automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20662 381
SS-Chr 19BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 7 5.79 g/dl 0.06 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37259 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 32.57 g/dl 0.12 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37389 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 32.7 g/dl 0.16 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37393 401
SS-Chr 19BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.19 mg/dl 0.1 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36646 401
SS-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 46.2 ml/min 8.98 26.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20230 381
SS-Chr 19BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 1 -41.1 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19502 381
SS-Chr 19BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 8 36.53 degrees C 0.34 0.95 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19089 381
SS-Chr 19BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 34.8 mmHg 2.41 7.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50019 461
SS-Chr 19BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 20.5 mmol/l 0.81 2.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42082 401
SS-Chr 19BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 59.9 U/l 5.88 18.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42792 401
SS-Chr 19BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 7 77.57 U/l 4.67 12.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42478 401
SS-Chr 19BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 7 66.0 U/l 3.09 8.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42482 401
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 130.92 % 15.94 45.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54348 381
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 155.63 % 10.18 32.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53658 381
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.13 mg/kg 0.17 0.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59229 526
SS-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 53.48 % 0.49 1.56 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59279 526
SS-Chr 19BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 21.3 mg/dl 1.31 4.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40850 401
SS-Chr 19BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.41 x 1000 cells/ul 0.19 0.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40948 401
SS-Chr 19BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 9 0.89 g/kg 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59515 526
SS-Chr 19BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 7 8.86 mg/dl 0.51 1.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37892 401
SS-Chr 19BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 17.8 mmol/l 0.66 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38283 401
SS-Chr 19BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 7 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41465 401
SS-Chr 19BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.15 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41888 401
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 87.31 mmHg 4.48 13.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45526 461
SS-Chr 19BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 35.16 mmHg 1.87 3.74 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16102 381
SS-Chr 19BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 1 31.7 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16106 381
SS-Chr 19BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 198.1 g 5.7 17.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55233 522
SS-Chr 19BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.82 g/mg 0.14 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57388 522
SS-Chr 19BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 9 0.23 null 0.01 0.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57962 526
SS-Chr 19BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.49 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16493 381
SS-Chr 19BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 193.0 g 3.3 10.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55470 522
SS-Chr 19BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 41.5 ml/min/kg 2.34 6.62 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58287 526
SS-Chr 19BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.09 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59949 526
SS-Chr 19BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.41 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17392 381
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 83.34 mmHg 7.59 22.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46770 461
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 101.7 mmHg 5.34 15.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45749 461
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 101.84 mmHg 5.89 18.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45751 461
SS-Chr 19BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 109.38 % 5.61 16.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44940 461
SS-Chr 19BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 100.39 % 17.82 47.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48315 461
SS-Chr 19BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 85.4 % 3.17 9.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48426 461
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 144.69 % 16.0 45.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54241 381
SS-Chr 19BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 0.77 g 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49082 461
SS-Chr 19BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 239.63 beats/min 12.68 38.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48965 461
SS-Chr 19BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.49 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17083 381
SS-Chr 19BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 7 5.67 g/dl 0.05 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37263 401
SS-Chr 19BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 6.59 x 1000 cells/ul 0.49 1.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36930 401
SS-Chr 19BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 79.7 mg/dl 2.38 7.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37117 401
SS-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 121.12 breaths/min 11.43 32.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14814 381
SS-Chr 19BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 8 101.79 mg/d 25.69 72.65 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52720 482
SS-Chr 19BN/Mcwi mammary tumor number 7,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152 days-162 days 14 8.79 null 1.25 4.68 necropsy 0 DMBA oral gavage 105 days necropsy 11507 86
SS-Chr 19BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -39.93 mmHg 1.85 3.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19498 381
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 11.35 ml/min/g 0.31 0.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46673 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 9.59 ml/min/g 0.75 2.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46890 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 9.96 ml/min/g 0.71 2.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46892 461
SS-Chr 19BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.24 x 1000 cells/ul 0.04 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39696 401
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 166.46 % 7.0 19.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54447 381
SS-Chr 19BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 187.1 g 4.7 15.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58403 526
SS-Chr 19BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 8 36.6 degrees C 0.3 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16832 381
SS-Chr 19BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.53 degrees C 0.11 0.32 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16834 381
SS-Chr 19BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 74.4 % 10.19 22.79 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54830 522
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 62.93 mmHg 2.41 5.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46437 461
SS-Chr 19BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.15 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41890 401
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 265.92 beats/min 7.32 23.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47604 461
SS-Chr 19BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 8 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59423 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 13.19 ml/min/kg 2.13 5.64 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60059 526
SS-Chr 19BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.29 g/dl 0.32 1.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37988 401
SS-Chr 19BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 42.49 % 0.54 1.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41367 401
SS-Chr 19BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 116.6 breaths/min 11.8 33.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14955 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during7-9 min hypercapnia/control during standard conditions 240.47 % 26.59 75.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14218 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 115.32 % 8.1 22.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54008 381
SS-Chr 19BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 421.0 beats/min 23.94 47.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20956 381
SS-Chr 19BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 1 480.45 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20960 381
SS-Chr 19BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 1 0.04 null automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19823 381
SS-Chr 19BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 3 113.81 mmHg 10.33 17.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19899 381
SS-Chr 19BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 113.95 breaths/min 10.23 30.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18432 381
SS-Chr 19BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 204.3 U/l 5.44 17.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36399 401
SS-Chr 19BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 1 101.7 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18906 381
SS-Chr 19BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.35 g/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36984 401
SS-Chr 19BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.3 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15417 381
SS-Chr 19BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 84.32 ml/min 4.73 13.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14520 381
SS-Chr 19BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 0.01 degrees C 0.37 1.04 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15689 381
SS-Chr 19BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 5 386.99 beats/min 19.02 42.54 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52669 482
SS-Chr 19BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 159.01 breaths/min 6.25 19.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17133 381
SS-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.28 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13945 381
SS-Chr 19BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 158.56 breaths/min 6.91 21.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16933 381
SS-Chr 19BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 8 271.1 g 7.0 19.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17837 381
SS-Chr 19BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -6.83 mmHg 2.08 3.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19667 381
SS-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 44.02 ml/min 6.34 19.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18684 381
SS-Chr 19BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 1 60.6 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20514 381
SS-Chr 19BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 877.0 s 22.7 68.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49319 461
SS-Chr 19BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 860.7 s 38.26 120.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49321 461
SS-Chr 19BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 18.89 % 2.12 6.36 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49718 461
SS-Chr 19BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 7 0.36 x 1000 cells/ul 0.06 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38961 401
SS-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 56.92 % 0.69 2.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39011 401
SS-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 53.48 % 0.49 1.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39013 401
SS-Chr 19BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 60.06 fl 0.38 1.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38765 401
SS-Chr 19BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 106.8 mmol/l 0.47 1.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39139 401
SS-Chr 19BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.82 g/dl 0.02 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42253 401
SS-Chr 19BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.7 mmol/l 0.54 1.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39408 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.05 g/dl 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39799 401
SS-Chr 19BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.4 x 1000 cells/ul 0.05 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43246 401
SS-Chr 19BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 13.9 g/dl 0.13 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40167 401
SS-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 237.8 g 7.3 22.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59082 526
SS-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 189.3 g 6.0 18.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59084 526
SS-Chr 19BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 7 3.99 g/dl 0.05 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40472 401
SS-Chr 19BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 52.6 U/l 11.21 35.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40734 401
SS-Chr 19BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 35.2 U/l 2.37 7.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40736 401
SS-Chr 19BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59567 526
SS-Chr 19BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.24 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59677 526
SS-Chr 19BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 149.0 mg/dl 6.48 17.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41255 401
SS-Chr 19BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 149.29 mg/dl 3.17 8.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41259 401
SS-Chr 19BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 6.95 x 1000 cells/ul 0.34 1.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41523 401
SS-Chr 19BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 24.27 % 5.17 13.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48547 461
SS-Chr 19BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 43.56 % 5.71 16.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48549 461
SS-Chr 19BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 149.4 mg/dl 4.19 13.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38552 401
SS-Chr 19BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 -7.17 null 0.08 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55327 522
SS-Chr 19BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 24.27 ml/min 2.25 7.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16169 381
SS-Chr 19BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 96.93 % 6.2 17.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48778 461
SS-Chr 19BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 42.06 % 0.77 2.04 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57548 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 21.29 ml/min/kg 1.72 5.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57820 526
SS-Chr 19BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.23 null 0.01 0.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57966 526
SS-Chr 19BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 -6.88 null 0.09 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55677 522
SS-Chr 19BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.45 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58135 526
SS-Chr 19BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 9 267.9 g 6.7 20.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58399 526
SS-Chr 19BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.42 null 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56159 522
SS-Chr 19BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 81.89 % 7.49 22.47 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54834 522
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 19.87 ml/min/kg 1.79 5.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58684 526
SS-Chr 19BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 1.93 E-7mole 0.14 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56570 522
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 63.07 mmHg 4.2 12.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47723 461
SS-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 58.82 % 5.72 17.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46086 461
SS-Chr 19BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 216.22 beats/min 14.24 40.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48967 461
SS-Chr 19BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 3 114.47 mmHg 12.96 22.44 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13518 381
SS-Chr 19BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.27 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18004 381
SS-Chr 19BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 94.7 mmHg 5.33 10.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18902 381
SS-Chr 19BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 99.9 U/l 4.03 12.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36401 401
SS-Chr 19BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 144.71 mmol/l 0.78 2.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36551 401
SS-Chr 19BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.47 ml/min/g 0.5 1.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46221 461
SS-Chr 19BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 47.2 % 6.3 18.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46339 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.87 ml/min/g 0.62 1.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46675 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 18.39 IU/g 1.31 3.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46007 461
SS-Chr 19BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 45.56 mmHg 3.92 11.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48055 461
SS-Chr 19BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 36.56 degrees C 0.27 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16592 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 181.83 % 14.12 44.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54449 381
SS-Chr 19BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 7 17.71 mg/dl 0.99 2.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41813 401
SS-Chr 19BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 1.45 E-7mole 0.26 0.65 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55946 522
SS-Chr 19BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 41.98 ml/min 6.53 18.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16710 381
SS-Chr 19BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 868.11 s 25.94 77.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50141 461
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 55.28 mmHg 4.02 11.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46439 461
SS-Chr 19BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 3.56 mmol/l 0.08 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43392 401
SS-Chr 19BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.84 g 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45427 461
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 89.06 mmHg 7.48 22.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45524 461
SS-Chr 19BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1084.8 s 39.82 125.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50249 461
SS-Chr 19BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.73 g/dl 0.08 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40468 401
SS-Chr 19BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.77 g/dl 0.05 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40572 401
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 23.09 IU/g 2.6 7.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48902 461
SS-Chr 19BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 17.15 g/dl 0.15 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37990 401
SS-Chr 19BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 1 134.49 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15131 381
SS-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.36 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13943 381
SS-Chr 19BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 1 119.41 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14369 381
SS-Chr 19BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 156.01 breaths/min 4.18 11.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17131 381
SS-Chr 19BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 1 27.8 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17279 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 104.82 % 3.83 10.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53907 381
SS-Chr 19BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 77.59 ml/min 4.57 12.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20781 381
SS-Chr 19BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 438.72 beats/min 31.16 53.97 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15961 381
SS-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.38 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15253 381
SS-Chr 19BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 0.27 ng/ml/h 0.04 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52473 482
SS-Chr 19BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 6 61.69 mg/d 17.26 42.28 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52718 482
SS-Chr 19BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 8 9.12 mEq/d 2.82 7.99 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52771 482
SS-Chr 19BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 6 163.66 mmHg 12.23 29.95 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52869 482
SS-Chr 19BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 36.54 degrees C 0.34 0.95 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13579 381
SS-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 54.94 ml/min 7.34 20.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18682 381
SS-Chr 19BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.54 degrees C 0.22 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19091 381
SS-Chr 19BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 7 142.86 mmol/l 1.84 4.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36555 401
SS-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 156.71 breaths/min 20.04 56.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18285 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 282.96 % 22.23 70.28 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19233 381
SS-Chr 19BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 0.26 degrees C 0.12 0.35 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20331 381
SS-Chr 19BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.95 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49080 461
SS-Chr 19BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.71 mg/dl 0.1 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36644 401
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 91.82 mmHg 6.4 15.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49908 461
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 95.37 mmHg 4.9 13.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49910 461
SS-Chr 19BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 36.67 mmHg 2.13 6.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50017 461
SS-Chr 19BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.58 g/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42255 401
SS-Chr 19BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.48 x 10E6 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39257 401
SS-Chr 19BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.24 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42707 401
SS-Chr 19BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 80.8 U/l 11.8 37.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42790 401
SS-Chr 19BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42948 401
SS-Chr 19BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 7 26.0 mmol/l 0.49 1.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43051 401
SS-Chr 19BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 7 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42944 401
SS-Chr 19BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.14 mmol/l 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43388 401
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 156.95 % 15.3 43.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53656 381
SS-Chr 19BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.07 mmHg-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59419 526
SS-Chr 19BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 10.01 mg/dl 0.3 0.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37616 401
SS-Chr 19BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59569 526
SS-Chr 19BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 7 2.06 g/dl 0.08 0.21 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41088 401
SS-Chr 19BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41669 401
SS-Chr 19BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 21.0 mmol/l 0.6 1.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38281 401
SS-Chr 19BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 7 18.43 mg/dl 0.57 1.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41817 401
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.36 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47499 461
SS-Chr 19BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 57.39 fl 0.49 1.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38712 401
SS-Chr 19BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 7.67 x 10E6 cells/ul 0.13 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42030 401
SS-Chr 19BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1029.33 s 28.48 85.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46568 461
SS-Chr 19BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 305.6 g 9.2 29.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55229 522
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 15.09 ml/min/kg 1.46 4.37 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57618 526
SS-Chr 19BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 84.0 % 5.99 14.67 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57276 522
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 22.46 IU/g 3.22 9.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48905 461
SS-Chr 19BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -7.0 null 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55681 522
SS-Chr 19BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.72 g/mg 0.08 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55840 522
SS-Chr 19BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 29.63 ml/min 2.95 8.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16712 381
SS-Chr 19BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.41 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58133 526
SS-Chr 19BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54730 522
SS-Chr 19BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58509 526
SS-Chr 19BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54960 522
SS-Chr 19BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.47 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59833 526
SS-Chr 19BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.09 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59953 526
SS-Chr 19BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.5 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17390 381
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 4.96 ml/min/g 0.4 1.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44740 461
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 69.12 mmHg 4.52 13.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47721 461
SS-Chr 19BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 4.91 g/kg 0.2 0.63 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47047 461
SS-Chr 19BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 263.71 beats/min 10.52 31.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48219 461
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 93.85 mmHg 2.92 8.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44837 461
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 104.08 % 12.79 36.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53775 381
SS-Chr 19BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.06 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19819 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during7-9 min hypercapnia/control during standard conditions 113.96 % 8.5 24.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18563 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypercapnia/control during standard conditions 261.36 % 28.96 81.9 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19231 381
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.29 IU/g 0.07 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47359 461
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 260.7 beats/min 48.91 129.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45168 461
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 28.89 mmHg 5.82 14.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45290 461
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 37.16 mmHg 4.21 12.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47931 461
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 30.78 mmHg 5.48 16.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47933 461
SS-Chr 19BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 0.07 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54726 522
SS-Chr 19BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 7 17.29 mmol/l 0.78 2.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43196 401
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 96.5 mmHg 5.92 18.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48646 461
SS-Chr 19BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 7 45.0 U/l 1.2 3.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37768 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 19.29 pg 0.24 0.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42565 401
SS-Chr 19BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 8 295.0 g 12.5 35.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55466 522
SS-Chr 19BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 105.88 breaths/min 7.81 24.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14957 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 135.44 % 13.4 37.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13700 381
SS-Chr 19BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 1 7.49 null automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17087 381
SS-Chr 19BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.24 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15419 381
SS-Chr 19BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 6 27.01 mg/d 7.32 17.92 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52618 482
SS-Chr 19BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 8 28.62 mg/d 8.44 23.88 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52620 482
SS-Chr 19BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.32 mg/dl 0.0 0.01 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52228 482
SS-Chr 19BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 124.2 mmHg 7.39 14.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14365 381
SS-Chr 19BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 64.36 ml/min 3.98 12.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20783 381
SS-Chr 19BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 4.53 x 1000 cells/ul 0.18 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36934 401
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 437.1 beats/min 20.79 41.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17538 381
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 1 408.35 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17542 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 151.12 % 18.83 56.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18565 381
SS-Chr 19BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 10.07 mg/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36820 401
SS-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 156.22 breaths/min 19.02 57.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18287 381
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.72 mmHg 0.4 1.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49197 461
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 4.97 mmHg 0.18 0.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49199 461
SS-Chr 19BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 20.7 % 2.78 8.79 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49720 461
SS-Chr 19BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1103.33 s 36.37 109.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50247 461
SS-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 145.8 g 5.0 15.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49574 461
SS-Chr 19BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 22.3 mmol/l 0.63 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42084 401
SS-Chr 19BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 106.1 mmol/l 0.35 1.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39137 401
SS-Chr 19BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.6 mmol/l 0.67 2.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39410 401
SS-Chr 19BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 19.43 mmol/l 0.43 1.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43192 401
SS-Chr 19BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.63 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43244 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.11 g/dl 0.23 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39797 401
SS-Chr 19BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.38 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39598 401
SS-Chr 19BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.2 x 1000 cells/ul 0.05 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40355 401
SS-Chr 19BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 11.01 mg/dl 0.31 0.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37614 401
SS-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 56.92 % 0.69 2.18 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59277 526
SS-Chr 19BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 8.03 x 1000 cells/ul 0.35 1.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40946 401
SS-Chr 19BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 42.06 % 0.77 2.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41363 401
SS-Chr 19BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.83 mmol/l 0.12 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38086 401
SS-Chr 19BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 85.57 mg/dl 4.04 10.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38494 401
SS-Chr 19BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41667 401
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.25 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47495 461
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 27.39 ml/min/kg 1.43 4.51 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57822 526
SS-Chr 19BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 76.67 % 4.97 14.92 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57280 522
SS-Chr 19BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 75.9 % 11.78 31.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48776 461
SS-Chr 19BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 42.49 % 0.54 1.43 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57552 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 19.18 ml/min/kg 0.77 2.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57620 526
SS-Chr 19BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 64.07 ml/min/kg 6.59 19.77 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58021 526
SS-Chr 19BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.18 E-7mole 0.18 0.58 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55950 522
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 82.34 mmHg 4.51 13.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46772 461
SS-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 30.25 % 1.7 4.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47097 461
SS-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 45.36 % 4.91 13.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47099 461
SS-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 58.82 % 5.59 16.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46088 461
SS-Chr 19BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 281.2 beats/min 12.75 38.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48217 461
SS-Chr 19BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 80.04 % 3.49 9.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48317 461
SS-Chr 19BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 7 1.05 ml/min 0.32 0.85 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52181 482
SS-Chr 19BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 7 9.6 mg/dl 0.07 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36824 401
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.13 mmHg 0.35 1.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47217 461
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.34 mmHg 0.12 0.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47219 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 5.61 ml/min/g 0.32 0.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46223 461
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 40.09 mmHg 5.31 15.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45292 461
SS-Chr 19BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.74 g/kg 0.19 0.59 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45672 461
SS-Chr 19BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 218.5 g 11.6 36.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47865 461
SS-Chr 19BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 10 159.6 g 7.4 23.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47869 461
SS-Chr 19BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.8 null 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56969 522
SS-Chr 19BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41469 401
SS-Chr 19BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 7 25.43 mmol/l 0.65 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43055 401
SS-Chr 19BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.1 g/mg 0.21 0.67 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55844 522
SS-Chr 19BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.4 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39596 401
SS-Chr 19BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.47 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56155 522
SS-Chr 19BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 19.94 % 3.07 9.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49418 461
SS-Chr 19BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 7 54.84 fl 0.19 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38708 401
SS-Chr 19BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 103.43 mmol/l 0.81 2.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40067 401
SS-Chr 19BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 1.09 g 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45425 461
SS-Chr 19BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 2.04 g/dl 0.04 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40570 401
SS-Chr 19BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 7 162.71 U/l 8.36 22.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37511 401
SS-Chr 19BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 7 1.69 g/dl 0.01 0.04 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41092 401
SS-Chr 19BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 65.25 ml/min 3.61 11.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14522 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 281.41 % 27.76 87.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14220 381
SS-Chr 19BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 430.66 beats/min 7.6 13.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14731 381
SS-Chr 19BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.9 degrees C 0.15 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13581 381
SS-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 148.22 breaths/min 18.63 55.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14816 381
SS-Chr 19BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 5 151.04 mmHg 12.97 29.0 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52867 482
SS-Chr 19BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 6 384.16 beats/min 17.74 43.46 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52671 482
SS-Chr 19BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 6 14.43 mEq/d 4.03 9.86 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52769 482
SS-Chr 19BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 6 1.38 mEq/d 0.14 0.34 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52965 482
SS-Chr 19BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 8 0.81 mEq/d 0.08 0.23 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52967 482
SS-Chr 19BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.42 mg/dl 0.04 0.11 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52230 482
SS-Chr 19BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 171.04 breaths/min 6.41 18.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16931 381
SS-Chr 19BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.44 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20658 381
SS-Chr 19BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.34 ml 0.04 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18002 381
SS-Chr 19BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 129.24 breaths/min 19.48 55.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18430 381
SS-Chr 19BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 98.6 mg/dl 8.06 25.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37119 401
SS-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 46.38 ml/min 6.24 17.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20228 381
SS-Chr 19BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 49.67 mmHg 3.42 5.92 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20510 381
SS-Chr 19BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 -0.04 degrees C 0.22 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20329 381
SS-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 179.6 g 6.4 20.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49570 461
SS-Chr 19BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 62.1 fl 0.4 1.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38767 401
SS-Chr 19BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 7 0.97 x 1000 cells/ul 0.26 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38957 401
SS-Chr 19BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.62 x 10E6 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39259 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.91 pg 0.15 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42567 401
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 138.74 % 15.35 46.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54350 381
SS-Chr 19BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 7.77 x 1000 cells/ul 0.3 0.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39946 401
SS-Chr 19BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 5.04 x 1000 cells/ul 0.18 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39950 401
SS-Chr 19BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.45 x 1000 cells/ul 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39694 401
SS-Chr 19BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.13 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40359 401
SS-Chr 19BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 7 103.71 mmol/l 1.32 3.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40071 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 18.77 pg 0.11 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40263 401
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.53 mg/kg 0.26 0.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59225 526
SS-Chr 19BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 7 99.29 U/l 4.88 12.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37515 401
SS-Chr 19BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 21.1 mg/dl 0.53 1.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40848 401
SS-Chr 19BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.46 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59679 526
SS-Chr 19BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.06 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59519 526
SS-Chr 19BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 7 32.14 U/l 3.49 9.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37772 401
SS-Chr 19BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.28 mmol/l 0.11 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38088 401
SS-Chr 19BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 7 9.43 mg/dl 0.32 0.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37888 401
SS-Chr 19BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.74 x 1000 cells/ul 0.16 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41525 401
SS-Chr 19BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 7 90.86 mg/dl 3.19 8.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38498 401
SS-Chr 19BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 147.8 mg/dl 3.9 12.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38550 401
SS-Chr 19BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1081.22 s 33.59 100.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46570 461
SS-Chr 19BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 7.41 x 10E6 cells/ul 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42034 401
SS-Chr 19BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.42 g/mg 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57384 522
SS-Chr 19BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 36.13 ml/min 5.29 14.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16167 381
SS-Chr 19BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 53.22 ml/min/kg 3.96 11.87 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58019 526
SS-Chr 19BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.42 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16495 381
SS-Chr 19BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 51.04 ml/min/kg 4.16 11.76 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58291 526
SS-Chr 19BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58511 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 22.47 ml/min/kg 3.14 8.3 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58688 526
SS-Chr 19BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.37 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58755 526
SS-Chr 19BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.7 E-7mole 0.22 0.67 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56574 522
SS-Chr 19BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.42 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59837 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 12.14 ml/min/kg 1.42 4.01 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60055 526
SS-Chr 19BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 5 -6.72 null 0.03 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56965 522
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 15.8 IU/g 1.18 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46003 461
SS-Chr 19BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 5.95 g/kg 0.24 0.73 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45668 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 3.38 ml/min/g 0.27 0.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44738 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.29 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47362 461
SS-Chr 19BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 125.95 % 10.81 32.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44938 461
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 210.35 beats/min 11.22 31.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45170 461
SS-Chr 19BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 84.34 % 4.95 14.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48428 461
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 165.56 % 7.12 20.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54107 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 185.92 % 15.26 48.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54109 381
SS-Chr 19BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 3 30.12 mmHg 1.72 2.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17275 381
SS-Chr 19BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.86 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36982 401
SS-Chr 19BN/Mcwi post-insult time to mammary tumor formation 7,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152 days-162 days 14 44.03 d 0.41 1.54 manual palpation method 0 DMBA oral gavage 105 days 200 mg DMBA in 10 ml seame oil 65569 86
SS-Chr 19BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 38.68 % 7.02 21.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46341 461
SS-Chr 19BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 4.38 g/kg 0.11 0.36 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47043 461
SS-Chr 19BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 53.22 mmHg 4.65 13.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48053 461
SS-Chr 19BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.79 degrees C 0.13 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16594 381
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 106.28 mmHg 2.92 8.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44835 461
SS-Chr 19BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 7 0.26 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42711 401
SS-Chr 19BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 25.16 % 3.4 9.63 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49416 461
SS-Chr 19BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 13.69 g/dl 0.21 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40163 401
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 262.16 beats/min 7.61 22.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47602 461
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.18 mg/kg 0.26 0.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58926 526
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 0.99 mg/kg 0.18 0.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58928 526
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 17.89 pg 0.03 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40259 401
SS-Chr 19BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 858.78 s 33.37 100.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50139 461
SS-Chr 19BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.44 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58753 526
SS-Chr 19BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54956 522
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 96.55 mmHg 5.34 15.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48644 461
SS-Chr 19BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.49 null 0.11 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55331 522