Phenominer Database Results (996 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 18BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 108.8 mmHg 1.77 4.33 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 15980 381
SS-Chr 18BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 0.29 degrees C 0.2 0.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16005 381
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 7.46 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14600 381
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 7.44 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14605 381
SS-Chr 18BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.38 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15411 381
SS-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 133.44 mmHg 3.43 8.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 15546 381
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 -0.46 degrees C 0.15 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15686 381
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.25 mEq/d 0.15 0.43 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51264 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 421.83 beats/min 9.17 22.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51283 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -55.5 beats/min 21.44 52.51 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51302 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -13.16 beats/min 18.71 41.84 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51306 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 32.05 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51338 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -60.48 beats/min 20.94 51.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51352 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 386.26 beats/min 6.07 14.87 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51481 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 33.19 mmHg 3.65 5.16 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51491 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 6.54 mmHg 3.5 7.83 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51498 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -37.54 beats/min 13.84 41.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51501 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -81.81 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51505 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 12.82 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51593 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -0.89 mmHg 3.73 9.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50698 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 28.48 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50720 481
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 172.09 % 6.43 27.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54239 381
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 16.23 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51022 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 45.65 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51423 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 29.29 mmHg 4.91 12.03 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50897 481
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 10 26.17 mmHg 1.75 5.53 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17265 381
SS-Chr 18BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 150.42 breaths/min 5.02 19.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17125 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 8.8 mmHg 4.46 10.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14023 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 151.65 % 13.31 35.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14035 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 108.81 mmHg 6.39 14.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 13764 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 104.88 mmHg 6.15 16.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 13769 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 112.44 breaths/min 5.18 20.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14808 381
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 2.83 mmHg 1.4 4.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50598 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 10 40.38 mg/d 6.82 21.57 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52713 482
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 9 12.51 mEq/d 0.99 2.97 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52760 482
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 1 1.05 ml/min urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51934 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -14.03 beats/min 11.24 27.53 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51977 481
SS-Chr 18BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 9 0.83 mEq/d 0.07 0.2 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52956 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 404.68 beats/min 23.22 56.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50474 481
SS-Chr 18BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 12 404.28 beats/min 8.59 29.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14722 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.39 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13643 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13648 381
SS-Chr 18BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 64.54 ml/min 6.82 18.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14165 381
SS-Chr 18BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.13 degrees C 0.17 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13573 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 27.98 mmHg 1.0 3.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13430 381
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 0.48 mmHg 1.96 4.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51663 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -57.41 beats/min 0.99 1.4 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50338 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -51.54 beats/min 9.58 23.46 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50343 481
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 36.26 ml/min 3.77 9.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20703 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 98.86 mmHg 2.65 6.5 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19530 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 53.73 mmHg 0.9 2.21 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19548 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -47.52 mmHg 1.07 2.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17934 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 126.26 mmHg 7.62 15.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17760 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 51.61 ml/min 4.67 14.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18066 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 467.49 beats/min 17.12 41.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18100 381
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20161 381
SS-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 94.94 breaths/min 3.61 15.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18427 381
SS-Chr 18BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.2 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36271 401
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 30.88 mmHg 1.2 2.07 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18819 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 100.03 mmHg 2.06 6.51 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18892 381
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.21 g/dl 0.09 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37381 401
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 26.68 mmHg 0.95 2.34 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19028 381
SS-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.18 mg/dl 0.24 0.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36638 401
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 13 399.04 beats/min 15.76 56.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17528 381
SS-Chr 18BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 6.52 g/dl 0.07 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37251 401
SS-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.27 degrees C 0.17 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19083 381
SS-Chr 18BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.34 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18627 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20542 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 102.13 mmHg 2.83 6.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20393 381
SS-Chr 18BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 474.64 beats/min 8.45 22.35 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20438 381
SS-Chr 18BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 37.79 degrees C 0.13 0.33 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19189 381
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 13 9.69 IU/g 1.44 5.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49829 461
SS-Chr 18BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 21.56 mg/dl 0.65 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42324 401
SS-Chr 18BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.51 x 1000 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38949 401
SS-Chr 18BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 25.0 mmol/l 0.85 2.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42196 401
SS-Chr 18BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 22.4 mmol/l 0.93 2.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42201 401
SS-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.57 g/dl 0.14 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42247 401
SS-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 18.5 mmol/l 0.68 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42076 401
SS-Chr 18BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.14 x 1000 cells/ul 0.06 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39504 401
SS-Chr 18BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 77.78 U/l 8.16 24.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42465 401
SS-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 76.22 U/l 5.44 16.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42784 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.08 g/dl 0.08 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39794 401
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.22 mg/kg 0.29 0.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58920 526
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 170.01 % 9.75 37.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53651 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 109.7 % 5.79 15.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54548 381
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 28.66 ml/min/kg 1.64 4.65 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 58994 526
SS-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 35.44 U/l 3.92 11.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40731 401
SS-Chr 18BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 45.67 U/l 6.44 19.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37677 401
SS-Chr 18BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 99.0 mmol/l 0.5 1.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 40517 401
SS-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 24 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59564 526
SS-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 29 1.57 g/kg 0.04 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59674 526
SS-Chr 18BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 2.29 g/dl 0.05 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41080 401
SS-Chr 18BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 151.2 mg/dl 5.74 18.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41247 401
SS-Chr 18BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.06 x 1000 cells/ul 0.02 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38362 401
SS-Chr 18BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38367 401
SS-Chr 18BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 2.09 g/dl 0.08 0.25 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 41591 401
SS-Chr 18BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 17.6 mg/dl 0.9 2.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41805 401
SS-Chr 18BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.0 x 1000 cells/ul 0.0 0.01 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41452 401
SS-Chr 18BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41457 401
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 14 0.29 IU/g 0.07 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47487 461
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -6.46 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 57406 522
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 12.74 ml/min/kg 1.11 4.46 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57615 526
SS-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 27.64 ml/min 1.92 8.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16164 381
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -7.04 null 0.13 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55669 522
SS-Chr 18BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 14 99.07 mmHg 1.83 6.86 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16401 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 5 105.61 mmHg 3.79 8.46 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16406 381
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.92 g/mg 0.12 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55827 522
SS-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.32 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58127 526
SS-Chr 18BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -8.02 null 0.04 0.13 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55998 522
SS-Chr 18BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -8.22 null 0.05 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56003 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 -8.18 null 0.17 0.74 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56148 522
SS-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 63.05 % 4.72 21.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54819 522
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 0.82 E-7mole 0.11 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56563 522
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54990 522
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -6.66 null 0.08 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55018 522
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -6.83 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55023 522
SS-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 22 0.38 null 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58747 526
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 2.86 E-7mole 0.23 0.74 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56784 522
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 12.14 ml/min/kg 1.78 5.33 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60047 526
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 14.74 ml/min/kg 0.83 2.36 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60079 526
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 4 40.5 % 1.94 3.87 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57152 522
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 129.71 mmHg 6.81 21.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45746 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 13 11.23 ml/min/g 0.85 3.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46670 461
SS-Chr 18BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 5 5.65 g/kg 0.19 0.43 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47030 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 213.38 beats/min 14.04 34.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45076 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 10.17 IU/g 0.68 1.66 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45113 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 15 0.43 IU/g 0.07 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47346 461
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -31.8 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50615 481
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 13 116.22 mmHg 2.74 9.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20050 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 5 113.6 mmHg 4.17 9.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20055 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -4.86 mmHg 0.72 1.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20589 381
SS-Chr 18BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20652 381
SS-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 118.97 mmHg 3.11 10.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15121 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 119.44 % 5.75 23.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53770 381
SS-Chr 18BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 284.53 beats/min 17.17 56.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48959 461
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 139.27 mmHg 3.66 10.35 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50638 481
SS-Chr 18BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 112.67 mmHg 6.55 11.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19970 381
SS-Chr 18BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 15 0.96 g 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49077 461
SS-Chr 18BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.0 null 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15352 381
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 1.66 ml/min 0.1 0.2 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51447 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 4 3.69 mg/d 0.88 1.77 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51563 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -3.2 mmHg 2.21 5.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51133 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 383.32 beats/min 7.64 20.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51243 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 6 11.86 mEq/d 1.63 3.99 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51293 481
SS-Chr 18BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.39 ml 0.04 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17675 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 1 117.69 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17767 381
SS-Chr 18BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.47 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17343 381
SS-Chr 18BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 9 334.7 g 8.2 24.6 whole body digital scale 0 Moms and pups used in studies were fed Dyets 18494 381
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -37.49 beats/min 6.24 18.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 52047 481
SS-Chr 18BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 275.36 % 16.82 50.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14085 381
SS-Chr 18BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.27 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14883 381
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 1 7.46 null automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19733 381
SS-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 7 37.51 degrees C 0.2 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19750 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 292.76 beats/min 77.04 203.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45162 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.25 mmHg 0.16 0.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47374 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 29.89 mmHg 6.0 14.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45284 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 287.03 beats/min 8.89 25.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45869 461
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 37.24 degrees C 0.11 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16589 381
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 14 828.5 s 38.98 145.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49316 461
SS-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 16 37.47 degrees C 0.12 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16826 381
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 1.1 E-7mole 0.16 0.46 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55938 522
SS-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 32.1 ml/min 2.56 10.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16707 381
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.03 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54718 522
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 190.24 % 5.88 15.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53560 381
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.58 g/mg 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56213 522
SS-Chr 18BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 57.43 fl 0.38 1.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38700 401
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 265.22 beats/min 8.38 25.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47596 461
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 0.06 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56263 522
SS-Chr 18BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 92.24 beats/min 22.5 55.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19169 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 134.12 % 11.39 30.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53729 381
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 131.2 mmHg 7.44 18.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48638 461
SS-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 2.25 g/dl 0.06 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40564 401
SS-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 65.5 % 4.1 12.96 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55104 522
SS-Chr 18BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.78 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40455 401
SS-Chr 18BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 5.53 x 1000 cells/ul 0.4 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40633 401
SS-Chr 18BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 81.3 mg/dl 2.68 8.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39205 401
SS-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.3 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 57722 526
SS-Chr 18BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 8.12 mg/dl 0.15 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37875 401
SS-Chr 18BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 175.7 g 6.1 19.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55458 522
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 121.87 breaths/min 5.75 17.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15370 381
SS-Chr 18BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.3 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15414 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 110.12 breaths/min 3.55 15.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14811 381
SS-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 95.65 breaths/min 5.91 22.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14949 381
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -67.69 beats/min 13.34 40.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51689 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 118.02 mmHg 3.47 8.5 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51741 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 8 23.12 mg/d 6.52 18.44 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51753 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 2.35 beats/min 11.45 28.06 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51790 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 14.15 mmHg 3.4 8.34 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51812 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51899 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 105.29 mmHg 2.43 5.43 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51323 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 107.87 mmHg 1.27 2.21 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51327 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 17.99 mmHg 2.07 6.2 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51334 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 2 0.73 ml/min 0.02 0.02 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51451 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87 days-120 days 7 3.47 mg/d 0.73 1.92 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51454 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 24.17 mmHg 4.29 10.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50964 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 3 1.67 ng/ml/h 0.55 0.96 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51006 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 4 1.03 ml/min 0.2 0.41 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51055 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 3.5 mmHg 5.0 12.25 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51494 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -92.93 beats/min 17.96 43.99 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51607 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 -18.8 mmHg 3.71 8.29 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50761 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 124.3 mmHg 1.8 4.42 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50793 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 4 112.87 mmHg 3.21 6.41 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50797 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -3.73 mmHg 1.03 2.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50917 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 -6.74 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50929 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -34.31 beats/min 15.69 47.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51197 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 -13.98 beats/min 6.5 15.92 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51211 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -96.0 beats/min 16.27 39.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51221 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 141.2 mmHg 2.44 7.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51626 481
SS-Chr 18BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 37.12 degrees C 0.13 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13576 381
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 440.68 beats/min 19.68 44.01 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50448 481
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 5 27.61 mmHg 1.7 3.8 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13435 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 109.6 mmHg 5.05 13.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14665 381
SS-Chr 18BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 433.43 beats/min 7.28 23.03 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15956 381
SS-Chr 18BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 5 0.08 degrees C 0.27 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16010 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.42 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15247 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 5.03 mmHg 3.26 7.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15179 381
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 11.56 mmHg 2.95 7.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 15539 381
SS-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 22.73 ml/min 1.97 5.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15616 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -6.54 mmHg 1.15 2.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15647 381
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 -0.14 degrees C 0.13 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15683 381
SS-Chr 18BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 97.65 ml/min 6.01 23.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14514 381
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 6 1.5 ml/min 0.11 0.27 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51930 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 5.12 beats/min 20.66 46.2 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51981 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 17.97 mg/d 3.01 9.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52609 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 10 406.58 beats/min 6.69 21.14 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52664 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 401.2 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50525 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 8 1.26 ml/min 0.18 0.5 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52174 482
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.33 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52223 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 444.41 beats/min 19.19 27.14 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50669 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 119.36 mmHg 4.72 11.57 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50672 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 115.54 mmHg 2.1 4.7 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50676 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 116.57 mmHg 6.67 16.34 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 13886 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 34.88 mmHg 0.96 2.36 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 13841 381
SS-Chr 18BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 548.23 beats/min 8.75 23.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14067 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 117.75 % 4.28 18.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53773 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 153.43 % 3.96 11.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53837 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 110.13 % 7.22 28.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54003 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 1 113.7 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19977 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19813 381
SS-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 110.17 mmHg 4.94 15.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19894 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.52 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17609 381
SS-Chr 18BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 5 38.24 degrees C 0.22 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17649 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 115.28 breaths/min 6.83 18.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17687 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 103.82 mmHg 3.14 7.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17694 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 101.24 mmHg 1.14 2.8 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19525 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 33.23 mmHg 1.06 2.6 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19565 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 270.01 % 9.86 29.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 19595 381
SS-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.79 degrees C 0.2 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 17566 381
SS-Chr 18BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 171.43 breaths/min 10.13 26.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20678 381
SS-Chr 18BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 460.14 beats/min 26.8 59.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17747 381
SS-Chr 18BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 17 279.2 g 4.6 19.0 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17831 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 120.14 mmHg 6.26 12.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19703 381
SS-Chr 18BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 4.69 x 1000 cells/ul 0.41 1.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36917 401
SS-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 95.34 breaths/min 3.63 14.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18424 381
SS-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.82 g/dl 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36976 401
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 30.38 mmHg 0.53 1.07 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19023 381
SS-Chr 18BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 6.16 g/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37246 401
SS-Chr 18BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 144.56 mmol/l 0.47 1.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36538 401
SS-Chr 18BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 9.48 mg/dl 0.12 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36597 401
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 40.41 ml/min 2.93 12.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20225 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 94.0 mmHg 4.35 11.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20398 381
SS-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 26.7 ml/min 2.98 7.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18186 381
SS-Chr 18BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 38.4 degrees C 0.2 0.52 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18221 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 118.35 breaths/min 4.53 19.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18282 381
SS-Chr 18BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 568.16 beats/min 9.06 18.12 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20525 381
SS-Chr 18BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 565.48 beats/min 13.86 33.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20530 381
SS-Chr 18BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 -0.04 null 0.01 0.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20559 381
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 73.5 mmHg 2.77 6.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49817 461
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 12 663.55 s 79.75 276.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50136 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1071.31 s 63.1 189.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50241 461
SS-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 60.85 fl 0.24 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38762 401
SS-Chr 18BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 117.9 U/l 9.63 30.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42150 401
SS-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 4.09 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42250 401
SS-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 8.53 x 10E6 cells/ul 0.36 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39251 401
SS-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 137.44 mmol/l 0.99 2.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39405 401
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 204.79 % 11.51 30.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54512 381
SS-Chr 18BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 4.55 x 1000 cells/ul 0.5 1.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39938 401
SS-Chr 18BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42936 401
SS-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.25 mg/dl 0.03 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39590 401
SS-Chr 18BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.18 x 1000 cells/ul 0.04 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40347 401
SS-Chr 18BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 6 4.85 mmol/l 0.19 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43375 401
SS-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.08 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 58861 526
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 107.5 % 6.97 20.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54543 381
SS-Chr 18BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 38.3 U/l 3.74 11.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37682 401
SS-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 6 5.88 mmol/l 0.22 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38080 401
SS-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 4.97 mmol/l 0.29 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38083 401
SS-Chr 18BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 28.29 ml/min/kg 2.02 6.38 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 59635 526
SS-Chr 18BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 17.56 mg/dl 0.73 2.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41800 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.13 pg 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38383 401
SS-Chr 18BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 57.14 fl 0.26 0.79 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38207 401
SS-Chr 18BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.05 x 1000 cells/ul 0.02 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41664 401
SS-Chr 18BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 14.86 g/dl 0.21 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41625 401
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.31 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47482 461
SS-Chr 18BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 163.44 mg/dl 3.99 11.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38547 401
SS-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.27 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41885 401
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.56 null 0.13 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55314 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 16.75 % 1.56 4.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 55359 522
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 21 1.14 g/mg 0.05 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57373 522
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -6.46 null 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 57401 522
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 12.78 ml/min/kg 1.11 4.01 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57814 526
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.58 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55703 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.42 null 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55708 522
SS-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.24 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57954 526
SS-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 15 42.88 ml/min/kg 2.65 10.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58016 526
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -2.85 mmHg 2.28 3.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16305 381
SS-Chr 18BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 470.71 beats/min 10.79 28.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 16355 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 28.71 mmHg 1.16 2.84 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16446 381
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 37.23 degrees C 0.12 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16586 381
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.04 g/mg 0.24 0.74 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55832 522
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.06 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56258 522
SS-Chr 18BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 99.4 % 0.6 1.9 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56317 522
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 21 -8.22 null 0.14 0.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56144 522
SS-Chr 18BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56192 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 27.86 % 4.61 12.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54847 522
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 19 0.02 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54949 522
SS-Chr 18BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -8.05 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56034 522
SS-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.04 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54713 522
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.46 mg/kg 0.22 0.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58923 526
SS-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 0.91 E-7mole 0.08 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56559 522
SS-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 59.7 % 6.23 19.7 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56844 522
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 20 -7.08 null 0.04 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56954 522
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.1 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56691 522
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 0.06 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56696 522
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 29.14 % 4.0 10.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56713 522
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.53 g/mg 0.11 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 56982 522
SS-Chr 18BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 45.88 % 0.63 1.9 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Dyets 60121 526
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 31.19 mmHg 1.22 3.85 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16092 381
SS-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 9.0 ml/min/g 0.57 2.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46887 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 10.89 ml/min/g 0.5 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46667 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 37.87 % 9.6 28.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46336 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.79 mmHg 0.11 0.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47211 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 5.29 ml/min/g 0.49 1.2 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44898 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 57.19 % 4.21 15.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47094 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 84.94 % 4.76 17.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48312 461
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 8.97 mmHg 1.29 2.89 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50844 481
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 117.32 % 4.27 18.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53905 381
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 10 8.38 mEq/d 0.48 1.51 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52764 482
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 429.89 beats/min 16.83 50.48 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50521 481
SS-Chr 18BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 87.53 beats/min 4.09 9.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20421 381
SS-Chr 18BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 75.02 beats/min 9.18 24.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 20426 381
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.67 degrees C 0.1 0.3 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18228 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 129.04 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51630 481
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17604 381
SS-Chr 18BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.48 ml 0.04 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17670 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 162.92 % 9.13 35.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54236 381
SS-Chr 18BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 0.0 null 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15347 381
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87 days-120 days 7 26.06 mg/d 2.21 5.85 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51552 481
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 14 31.93 mmHg 0.72 2.7 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 14467 381
SS-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 30.65 ml/min 2.62 7.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15611 381
SS-Chr 18BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 1 0.01 null stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19920 381
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 5.78 mmHg 0.15 0.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49194 461
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 18.8 mmHg 5.66 11.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 15534 381
SS-Chr 18BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 1 98.71 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18356 381
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -23.6 beats/min 13.04 31.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50359 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 -1.93 mmHg 2.59 6.35 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50430 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 12 112.59 mmHg 3.72 12.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13509 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 100.06 mmHg 2.55 7.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18896 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.37 ml 0.02 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15250 381
SS-Chr 18BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 13 123.96 mmHg 4.3 15.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18943 381
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -98.78 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51693 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -115.34 beats/min 17.44 42.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51707 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -43.88 beats/min 13.58 33.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51721 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 24.22 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51771 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 7 1.73 ml/min 0.16 0.42 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51796 481
SS-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 219.0 U/l 21.48 67.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36393 401
SS-Chr 18BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 500.97 beats/min 26.64 59.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13803 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 35.59 mmHg 1.57 3.86 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 13836 381
SS-Chr 18BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.38 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17348 381
SS-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 6.17 g/dl 0.09 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36979 401
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 54.01 % 4.26 12.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47091 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 39.86 % 9.5 26.86 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47169 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 8.02 IU/g 1.87 4.19 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45116 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 82.86 % 8.81 29.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48423 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 40.66 % 6.81 20.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46333 461
SS-Chr 18BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 5 6.16 g/kg 0.28 0.64 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47035 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 44.47 % 10.09 28.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48001 461
SS-Chr 18BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 12 54.67 mmHg 4.42 15.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48050 461
SS-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.39 x 1000 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39688 401
SS-Chr 18BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 24.56 mmol/l 1.08 3.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43179 401
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 116.96 % 6.82 20.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54555 381
SS-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.33 mg/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41882 401
SS-Chr 18BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.26 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42022 401
SS-Chr 18BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 9 343.2 g 6.0 18.0 whole body digital scale 0 Moms and pups used in studies were fed Dyets 58450 526
SS-Chr 18BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.23 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40460 401
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 89.13 mmHg 6.03 22.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49905 461
SS-Chr 18BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 104.2 mmol/l 0.44 1.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40059 401
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.24 mg/kg 0.12 0.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59212 526
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 33.1 % 6.52 20.6 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55085 522
SS-Chr 18BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 46.19 % 0.46 1.37 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57535 526
SS-Chr 18BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 61.75 ml/min 5.88 15.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 16236 381
SS-Chr 18BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.9 g/dl 0.21 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37982 401
SS-Chr 18BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.68 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 16326 381
SS-Chr 18BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 0.47 x 1000 cells/ul 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39362 401
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87 days-120 days 3 0.84 ng/ml/h 0.08 0.14 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51836 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -42.21 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51850 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 12.61 mEq/d 0.77 2.17 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51885 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 14.06 mmHg 2.07 2.92 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51738 481
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.33 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14903 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 141.37 % 10.66 28.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53526 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 131.22 mmHg 4.62 11.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50942 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -6.56 beats/min 8.43 18.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50980 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 6 1.16 mEq/d 0.25 0.62 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51044 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 2 1.42 mmHg 1.42 2.0 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51083 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 407.56 beats/min 12.77 38.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51112 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 18.38 mmHg 3.39 8.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51187 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 2 -22.91 beats/min 7.09 10.03 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51214 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 120.15 mmHg 2.48 6.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50737 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 1 45.19 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50751 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -1.42 mmHg 2.23 5.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50778 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 37.27 mmHg 5.13 11.48 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50788 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 4 5.22 mEq/d 2.07 4.13 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51297 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 394.09 beats/min 7.89 17.63 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51379 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 10.88 beats/min 6.24 13.95 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50904 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -39.28 beats/min 14.49 32.41 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51408 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 4 19.43 mg/d 3.2 6.4 automated urine analysis 0 Moms and pups used in studies were fed Dyets 51437 481
SS-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87 days-120 days 8 2.78 mg/d 0.7 1.97 automated urine analysis 0 Moms and pups used in studies were fed Teklad 51469 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 445.12 beats/min 21.94 43.88 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51485 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 28.44 mmHg 4.62 11.33 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51488 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.28 mg/dl 0.06 0.14 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51533 481
SS-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87 days-120 days 5 21.44 mg/d 6.52 14.57 automated urine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51556 481
SS-Chr 18BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 13 484.14 beats/min 9.02 32.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13799 381
SS-Chr 18BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 521.35 beats/min 10.07 22.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14062 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17073 381
SS-Chr 18BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 158.43 breaths/min 5.07 21.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17128 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 8.23 mmHg 4.51 9.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14018 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 144.31 % 6.64 19.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14030 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 109.83 % 3.47 14.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54006 381
SS-Chr 18BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20022 381
SS-Chr 18BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20027 381
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 13 7.74 mmHg 2.69 9.7 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20728 381
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.42 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19726 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19809 381
SS-Chr 18BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 70.19 beats/min 25.96 44.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18349 381
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.25 g/dl 0.12 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 36307 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 32.42 g/dl 0.12 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 36312 401
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.46 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19011 381
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.47 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19016 381
SS-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 71.78 mg/dl 2.31 6.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37114 401
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 3 11.29 mmHg 4.37 7.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15142 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 4.91 mmHg 3.16 7.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15184 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 125.83 mmHg 3.49 8.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52088 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 1.04 ng/ml/h 0.18 0.51 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52468 482
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 2 1.29 ng/ml/h 0.49 0.69 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50569 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -20.32 beats/min 34.38 84.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50586 481
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 7.51 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14148 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during7-9 min hypercapnia/control during standard conditions 260.39 % 17.2 66.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14212 381
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 1 -32.32 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50421 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.26 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51647 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 451.67 beats/min 18.13 44.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50327 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 6.33 mmHg 2.64 6.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50369 481
SS-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 105.9 breaths/min 5.97 17.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17790 381
SS-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 111.35 mmHg 6.38 16.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19518 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 135.3 breaths/min 8.07 24.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17682 381
SS-Chr 18BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 37.74 degrees C 0.15 0.56 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18128 381
SS-Chr 18BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 14 7.47 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20156 381
SS-Chr 18BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 7.47 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20648 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 51.51 ml/min 2.48 9.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18676 381
SS-Chr 18BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 3.9 x 1000 cells/ul 0.22 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37303 401
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 44.08 ml/min 2.32 9.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20222 381
SS-Chr 18BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 235.99 beats/min 11.89 37.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48962 461
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 38.04 degrees C 0.14 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18233 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 115.55 breaths/min 4.5 18.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18279 381
SS-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 114.46 mmHg 5.82 14.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 19513 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 5 29.47 mmHg 0.59 1.33 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20409 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 28.51 mmHg 0.48 1.27 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20414 381
SS-Chr 18BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 9.56 mg/dl 0.17 0.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36807 401
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 57.54 mmHg 1.58 4.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20500 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 54.09 mmHg 1.49 3.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20504 381
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 61.71 mmHg 4.49 11.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49820 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 15 27.34 % 4.09 15.82 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49413 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 14 18.8 % 5.2 19.44 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49715 461
SS-Chr 18BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 0.76 x 1000 cells/ul 0.09 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38944 401
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 55.93 % 0.68 1.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39008 401
SS-Chr 18BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 21.0 mg/dl 0.71 2.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42329 401
SS-Chr 18BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 8.02 x 10E6 cells/ul 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 42381 401
SS-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 21.0 mmol/l 0.83 2.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42079 401
SS-Chr 18BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 4.23 mmol/l 0.21 0.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42157 401
SS-Chr 18BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 144.22 mmol/l 0.7 2.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39074 401
SS-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 104.11 mmol/l 0.77 2.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39134 401
SS-Chr 18BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 24.67 mmol/l 0.55 1.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42508 401
SS-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 65.22 U/l 4.86 14.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42787 401
SS-Chr 18BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.2 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39499 401
SS-Chr 18BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.07 g/dl 0.06 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39526 401
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 125.74 % 3.95 16.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54346 381
SS-Chr 18BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 5.76 x 1000 cells/ul 0.46 1.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39933 401
SS-Chr 18BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 0.9 g/kg 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 59018 526
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 22 241.7 g 8.0 37.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59076 526
SS-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.11 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39691 401
SS-Chr 18BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 14.89 g/dl 0.12 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40150 401
SS-Chr 18BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 170.44 mg/dl 5.41 16.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 40665 401
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.55 mg/kg 0.17 0.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59217 526
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 55.54 % 0.67 2.0 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59271 526
SS-Chr 18BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 49.67 U/l 3.53 10.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37755 401
SS-Chr 18BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 47.4 % 0.53 1.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41355 401
SS-Chr 18BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 6.96 mg/dl 0.38 1.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37880 401
SS-Chr 18BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 15.0 g/dl 0.22 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41620 401
SS-Chr 18BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.49 x 1000 cells/ul 0.61 1.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41520 401
SS-Chr 18BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 6.16 g/dl 0.13 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41837 401
SS-Chr 18BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 20.5 mmol/l 0.7 2.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38275 401
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 12.37 % 4.23 11.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48708 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 15 0.84 g 0.06 0.24 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45422 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 26.4 % 7.86 23.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48541 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 939.85 s 24.21 83.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46562 461
SS-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 1.05 null 0.09 0.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57748 526
SS-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 85.75 % 5.71 16.15 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57263 522
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 35.53 mmHg 1.31 3.7 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16096 381
SS-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 20 1.56 g/mg 0.11 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57377 522
SS-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 36.08 ml/min 2.82 10.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16161 381
SS-Chr 18BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.52 ml 0.03 0.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16490 381
SS-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -7.02 null 0.09 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55664 522
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 28.01 mmHg 0.79 2.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16451 381
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 6.68 mmHg 5.35 11.95 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 16774 381
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 10.88 mmHg 3.92 10.38 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 16779 381
SS-Chr 18BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 201.2 g 5.0 15.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58391 526
SS-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.03 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55718 522
SS-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 24 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58506 526
SS-Chr 18BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 17.63 % 2.58 7.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Dyets 54978 522
SS-Chr 18BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.2 10E-7mol/l 0.03 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56242 522
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.3 mg/kg 0.19 0.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58844 526
SS-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.11 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59936 526
SS-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.11 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59941 526
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 12 60.96 mmHg 3.69 12.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47715 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 56.19 % 12.59 35.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45923 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 80.0 % 2.9 11.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46080 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 112.05 mmHg 6.52 21.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44832 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 8 1.67 g 0.07 0.2 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45380 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 8 1.32 g 0.03 0.08 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45383 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 102.5 mmHg 7.71 18.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49155 461
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -60.45 beats/min 16.96 50.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50716 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 5 0.3 ng/ml/h 0.03 0.07 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50535 481
SS-Chr 18BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 13 414.26 beats/min 7.06 25.47 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20946 381
SS-Chr 18BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 -0.02 null 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20564 381
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 398.3 beats/min 7.53 18.44 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50666 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87 days-120 days 8 0.7 ng/ml/h 0.15 0.42 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50455 481
SS-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 7 37.57 degrees C 0.21 0.56 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 17571 381
SS-Chr 18BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 158.98 breaths/min 3.47 9.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17621 381
SS-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 88.35 breaths/min 6.08 16.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17795 381
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -5.9 beats/min 15.92 38.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51237 481
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 0.47 degrees C 0.21 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19577 381
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