Phenominer Database Results (402 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 15BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.23 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15400 381
SS-Chr 15BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 155.7 % 12.63 35.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54224 381
SS-Chr 15BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 7 95.15 mg/d 25.23 66.74 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52699 482
SS-Chr 15BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 129.4 % 8.48 32.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53757 381
SS-Chr 15BN/Mcwi absolute change in blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 0.04 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19789 381
SS-Chr 15BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 441.91 beats/min 27.7 55.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20928 381
SS-Chr 15BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 179.55 breaths/min 7.51 29.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16914 381
SS-Chr 15BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.46 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20628 381
SS-Chr 15BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 142.25 U/l 15.3 43.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36383 401
SS-Chr 15BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.64 g/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36965 401
SS-Chr 15BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 77.9 mg/dl 3.39 10.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37100 401
SS-Chr 15BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.6 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37226 401
SS-Chr 15BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 144.03 breaths/min 6.13 23.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18268 381
SS-Chr 15BN/Mcwi absolute change in partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 -38.5 mmHg 3.55 7.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19468 381
SS-Chr 15BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 880.5 s 23.77 75.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49302 461
SS-Chr 15BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 40.5 mmHg 2.9 9.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50000 461
SS-Chr 15BN/Mcwi partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 69.8 mmHg 5.9 8.34 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20482 381
SS-Chr 15BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 56.14 % 0.78 2.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38994 401
SS-Chr 15BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 85.5 U/l 5.01 15.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42443 401
SS-Chr 15BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.65 g/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42236 401
SS-Chr 15BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 8.85 x 10E6 cells/ul 0.18 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39240 401
SS-Chr 15BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 27.2 mmol/l 0.93 2.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43016 401
SS-Chr 15BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.38 mg/dl 0.03 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39579 401
SS-Chr 15BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.28 x 1000 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39677 401
SS-Chr 15BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 6.53 x 1000 cells/ul 0.54 1.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39911 401
SS-Chr 15BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.37 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40320 401
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 0.86 mg/kg 0.16 0.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58910 526
SS-Chr 15BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 9.81 mg/dl 0.29 0.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37853 401
SS-Chr 15BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 9.22 mg/dl 0.25 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37855 401
SS-Chr 15BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.78 g/dl 0.03 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41053 401
SS-Chr 15BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 146.0 mg/dl 2.88 9.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41220 401
SS-Chr 15BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 43.74 % 0.44 1.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41328 401
SS-Chr 15BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41650 401
SS-Chr 15BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1094.8 s 55.78 176.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46552 461
SS-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 269.09 beats/min 10.68 33.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47585 461
SS-Chr 15BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 238.82 beats/min 7.25 22.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48949 461
SS-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.39 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58116 526
SS-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.94 E-7mole 0.34 1.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55911 522
SS-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 0.92 E-7mole 0.15 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55913 522
SS-Chr 15BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 266.3 g 5.0 15.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58364 526
SS-Chr 15BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.44 degrees C 0.12 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16815 381
SS-Chr 15BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 44.79 ml/min/kg 4.77 11.69 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58254 526
SS-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.03 mmHg-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58492 526
SS-Chr 15BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.36 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17373 381
SS-Chr 15BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 35.14 mmHg 2.56 5.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16072 381
SS-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 61.56 % 6.54 19.63 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57241 522
SS-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 79.38 % 4.64 13.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57243 522
SS-Chr 15BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 10.01 ml/min/g 0.47 1.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46657 461
SS-Chr 15BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 6.24 g/kg 0.18 0.53 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45635 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 48.94 mmHg 4.66 14.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47704 461
SS-Chr 15BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 55.65 mmHg 6.78 21.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47915 461
SS-Chr 15BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 55.48 % 7.06 22.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46322 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.68 ml/min/g 0.27 0.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46205 461
SS-Chr 15BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 41.53 % 2.44 7.73 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47080 461
SS-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 220.39 beats/min 8.16 25.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45151 461
SS-Chr 15BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 15 210.2 g 16.5 63.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17820 381
SS-Chr 15BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 8 37.42 degrees C 0.25 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19073 381
SS-Chr 15BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 105.75 mmHg 0.15 0.21 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18874 381
SS-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during7-9 min hypercapnia/control during standard conditions 274.77 % 28.72 81.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14202 381
SS-Chr 15BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.6 g/dl 0.11 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36966 401
SS-Chr 15BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 85.75 mg/dl 3.69 10.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37101 401
SS-Chr 15BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.3 mmol/l 0.84 2.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36516 401
SS-Chr 15BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.3 mmol/l 0.34 1.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36518 401
SS-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.36 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52208 482
SS-Chr 15BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 267.43 beats/min 8.84 27.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48201 461
SS-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.41 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47326 461
SS-Chr 15BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.67 ml/min/g 0.51 1.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46656 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 100.06 mmHg 8.02 25.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44819 461
SS-Chr 15BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.46 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39580 401
SS-Chr 15BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.35 degrees C 0.12 0.46 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16575 381
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 17.1 ml/min/kg 1.28 3.38 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58649 526
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 21.93 ml/min/kg 2.37 5.79 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58651 526
SS-Chr 15BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 7.65 x 10E6 cells/ul 0.07 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41995 401
SS-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 14 0.43 null 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58737 526
SS-Chr 15BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 25.38 mg/dl 1.6 4.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40832 401
SS-Chr 15BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.57 g/mg 0.06 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57351 522
SS-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 30.41 IU/g 3.79 11.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48873 461
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.21 mg/kg 0.26 0.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59190 526
SS-Chr 15BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 57.5 U/l 3.08 9.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37733 401
SS-Chr 15BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.74 x 10E6 cells/ul 0.11 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39241 401
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 20.68 pg 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42549 401
SS-Chr 15BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 143.13 mmol/l 0.55 1.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39392 401
SS-Chr 15BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 120.13 breaths/min 6.05 23.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14938 381
SS-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during7-9 min hypercapnia/control during standard conditions 227.93 % 14.18 54.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14201 381
SS-Chr 15BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 2 126.84 mmHg 7.95 11.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13491 381
SS-Chr 15BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 111.36 % 6.23 19.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53890 381
SS-Chr 15BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 59.03 ml/min 3.45 13.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20764 381
SS-Chr 15BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 2 133.32 mmHg 6.53 9.23 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19872 381
SS-Chr 15BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.47 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37224 401
SS-Chr 15BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 414.45 beats/min 11.11 22.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14702 381
SS-Chr 15BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 -0.24 degrees C 0.29 0.83 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15673 381
SS-Chr 15BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 3 1.78 ml/min 0.21 0.37 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52160 482
SS-Chr 15BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 0.28 ng/ml/h 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52453 482
SS-Chr 15BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 3 1.73 ng/ml/h 0.2 0.35 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52454 482
SS-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 57.74 mg/d 11.69 30.93 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52598 482
SS-Chr 15BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 135.9 % 9.22 35.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13683 381
SS-Chr 15BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 164.04 breaths/min 2.74 10.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17114 381
SS-Chr 15BN/Mcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 6 28.63 mmHg 1.78 4.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17245 381
SS-Chr 15BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 185.3 U/l 10.07 31.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37476 401
SS-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 134.97 % 8.52 26.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18547 381
SS-Chr 15BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 39.15 ml/min 3.63 14.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20211 381
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.36 g/dl 0.14 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37354 401
SS-Chr 15BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 201.1 g 6.3 19.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49535 461
SS-Chr 15BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 156.3 g 2.8 8.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49537 461
SS-Chr 15BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 18.4 mmol/l 1.19 3.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42065 401
SS-Chr 15BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 63.51 fl 0.56 1.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38748 401
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.29 pg 0.19 0.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42548 401
SS-Chr 15BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.3 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42672 401
SS-Chr 15BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 74.38 U/l 5.98 16.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42774 401
SS-Chr 15BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.78 x 1000 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43227 401
SS-Chr 15BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 28.5 mmol/l 0.7 2.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43018 401
SS-Chr 15BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 130.33 % 9.52 36.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54330 381
SS-Chr 15BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 164.3 % 8.84 34.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54429 381
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 31.93 g/dl 0.12 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39780 401
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.37 pg 0.11 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40226 401
SS-Chr 15BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 14.15 g/dl 0.14 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40128 401
SS-Chr 15BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 102.1 mmol/l 0.77 2.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40032 401
SS-Chr 15BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 16.0 mmol/l 0.61 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43159 401
SS-Chr 15BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 56.14 % 0.78 2.47 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59260 526
SS-Chr 15BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 11.07 mg/dl 0.81 2.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37597 401
SS-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.04 mmHg-1 0.02 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59386 526
SS-Chr 15BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.21 g/kg 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59482 526
SS-Chr 15BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 14 1.63 g/kg 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59661 526
SS-Chr 15BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 133.25 mg/dl 3.53 9.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38533 401
SS-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.27 null 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55292 522
SS-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 89.88 % 6.59 20.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48759 461
SS-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 81.43 % 5.13 13.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48760 461
SS-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 9 0.26 null 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57927 526
SS-Chr 15BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 61.62 ml/min/kg 5.7 16.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58003 526
SS-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 2.23 E-7mole 0.45 1.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56537 522
SS-Chr 15BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 5.03 ml/min/g 0.53 1.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44722 461
SS-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 106.51 % 4.13 13.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44921 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 96.97 mmHg 4.21 13.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44818 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.19 mmHg 0.18 0.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47201 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.84 ml/min/g 0.95 2.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46204 461
SS-Chr 15BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 87.06 % 2.11 6.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48409 461
SS-Chr 15BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 49.91 mmHg 4.4 11.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45274 461
SS-Chr 15BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 33.16 ml/min 3.54 11.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20212 381
SS-Chr 15BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 63.32 ml/min 5.94 16.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20765 381
SS-Chr 15BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.45 null 0.04 0.06 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20630 381
SS-Chr 15BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 140.63 mmHg 12.18 24.37 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15097 381
SS-Chr 15BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.28 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17985 381
SS-Chr 15BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 201.7 U/l 6.5 20.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36382 401
SS-Chr 15BN/Mcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 137.78 mmHg 11.93 23.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14335 381
SS-Chr 15BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.13 x 1000 cells/ul 0.18 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36897 401
SS-Chr 15BN/Mcwi blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.5 null 0.07 0.1 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17055 381
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.32 g/dl 0.16 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37356 401
SS-Chr 15BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 89.89 % 3.11 9.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48410 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.3 ml/min/g 1.19 3.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46873 461
SS-Chr 15BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.51 x 1000 cells/ul 0.62 1.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41507 401
SS-Chr 15BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 24.35 ml/min 1.65 5.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16694 381
SS-Chr 15BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 19.75 mmol/l 0.53 1.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38265 401
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 97.71 mmHg 5.39 14.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49892 461
SS-Chr 15BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 14.28 g/dl 0.19 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40130 401
SS-Chr 15BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.49 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43228 401
SS-Chr 15BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 115.86 mmHg 9.63 28.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48628 461
SS-Chr 15BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 11.4 mg/dl 0.51 1.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37598 401
SS-Chr 15BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.19 g/mg 0.11 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57353 522
SS-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59551 526
SS-Chr 15BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 4.83 mmol/l 0.26 0.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38070 401
SS-Chr 15BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 464.17 beats/min 22.72 45.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15932 381
SS-Chr 15BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 2 382.79 beats/min 33.08 46.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15934 381
SS-Chr 15BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 69.11 ml/min 6.15 17.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14504 381
SS-Chr 15BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 157.38 breaths/min 7.11 20.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17115 381
SS-Chr 15BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 105.08 % 2.85 11.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53889 381
SS-Chr 15BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 100.61 % 5.46 21.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53990 381
SS-Chr 15BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 121.41 mmHg 6.21 12.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19870 381
SS-Chr 15BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.27 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15236 381
SS-Chr 15BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 143.47 breaths/min 9.63 37.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14797 381
SS-Chr 15BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 7 1.97 mEq/d 0.89 2.35 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52945 482
SS-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 46.16 mg/d 15.16 40.11 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52599 482
SS-Chr 15BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.29 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17986 381
SS-Chr 15BN/Mcwi absolute change in partial pressure of blood carbon dioxide air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 -1.2 mmHg 3.8 5.37 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19639 381
SS-Chr 15BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 13 169.4 g 9.3 33.6 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17821 381
SS-Chr 15BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 10.01 mg/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36785 401
SS-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 21.34 % 1.21 3.63 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49701 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 93.92 mmHg 6.52 20.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49891 461
SS-Chr 15BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 65.05 fl 0.28 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38749 401
SS-Chr 15BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.24 x 1000 cells/ul 0.03 0.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40322 401
SS-Chr 15BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.27 x 1000 cells/ul 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39678 401
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 0.69 mg/kg 0.16 0.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59192 526
SS-Chr 15BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 6.26 x 1000 cells/ul 0.73 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40930 401
SS-Chr 15BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.73 g/dl 0.08 0.21 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40554 401
SS-Chr 15BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.31 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59660 526
SS-Chr 15BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 0.96 g/kg 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59480 526
SS-Chr 15BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.03 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41432 401
SS-Chr 15BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 94.8 mg/dl 1.53 4.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38459 401
SS-Chr 15BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 102.05 mmHg 9.24 29.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48627 461
SS-Chr 15BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 307.1 g 6.9 21.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55197 522
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 16.83 ml/min/kg 1.55 4.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57803 526
SS-Chr 15BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 43.74 % 0.44 1.38 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57513 526
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 12.63 ml/min/kg 1.55 4.38 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57602 526
SS-Chr 15BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.39 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16477 381
SS-Chr 15BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 294.1 g 2.7 8.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55431 522
SS-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.25 null 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57929 526
SS-Chr 15BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 45.22 ml/min/kg 2.98 8.44 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58002 526
SS-Chr 15BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.49 degrees C 0.26 0.82 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16816 381
SS-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.06 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54691 522
SS-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 64.6 % 7.03 22.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54799 522
SS-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.23 E-7mole 0.16 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56539 522
SS-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.1 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59916 526
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 10.8 ml/min/kg 0.6 1.6 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60020 526
SS-Chr 15BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 41.2 mmHg 4.6 14.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48037 461
SS-Chr 15BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 7 14.44 mEq/d 3.52 9.31 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52750 482
SS-Chr 15BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 172.18 % 10.77 30.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54090 381
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.26 mmHg 0.22 0.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49181 461
SS-Chr 15BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.29 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15237 381
SS-Chr 15BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 41.75 ml/min 3.0 11.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18665 381
SS-Chr 15BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 58.52 % 6.72 21.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46323 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 107.31 mmHg 9.17 29.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45732 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 44.41 mmHg 5.73 18.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47705 461
SS-Chr 15BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 97.92 mmHg 9.16 28.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46754 461
SS-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 98.9 % 4.42 13.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44922 461
SS-Chr 15BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 4.64 g/kg 0.12 0.39 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47008 461
SS-Chr 15BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 4.89 g/kg 0.19 0.6 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47010 461
SS-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 65.65 % 3.49 11.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46070 461
SS-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.35 null 0.01 0.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58117 526
SS-Chr 15BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41651 401
SS-Chr 15BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 176.67 % 10.3 29.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54430 381
SS-Chr 15BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 45.11 ml/min/kg 4.94 12.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58252 526
SS-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 7 0.05 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54693 522
SS-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 6.47 % 1.15 3.25 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49702 461
SS-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 17.1 % 2.95 9.32 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49400 461
SS-Chr 15BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.04 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45408 461
SS-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 212.14 beats/min 15.56 46.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47586 461
SS-Chr 15BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 43.29 % 3.86 10.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48531 461
SS-Chr 15BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.99 g/dl 0.06 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40553 401
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 11.89 ml/min/kg 1.26 3.58 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57601 526
SS-Chr 15BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 56.86 % 0.74 2.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38995 401
SS-Chr 15BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 8 209.9 g 7.3 20.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55433 522
SS-Chr 15BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 138.52 % 6.42 24.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54223 381
SS-Chr 15BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13927 381
SS-Chr 15BN/Mcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 2 26.1 mmHg 4.4 6.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17247 381
SS-Chr 15BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 135.01 % 9.64 30.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53758 381
SS-Chr 15BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 101.55 % 5.26 16.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53991 381
SS-Chr 15BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 116.01 breaths/min 6.7 25.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18413 381
SS-Chr 15BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 5 154.32 mmHg 18.48 41.32 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52848 482
SS-Chr 15BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 5 403.16 beats/min 14.0 31.31 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52650 482
SS-Chr 15BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 7 2.52 ml/min 0.27 0.71 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52159 482
SS-Chr 15BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 123.2 mmHg 7.17 14.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13489 381
SS-Chr 15BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.36 mg/dl 0.09 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36627 401
SS-Chr 15BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.43 mg/dl 0.15 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36628 401
SS-Chr 15BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.68 mg/dl 0.1 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36787 401
SS-Chr 15BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 35.96 ml/min 3.46 10.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18666 381
SS-Chr 15BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 95.7 U/l 3.92 12.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37478 401
SS-Chr 15BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 0.78 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49064 461
SS-Chr 15BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 -0.09 degrees C 0.15 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20312 381
SS-Chr 15BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.37 degrees C 0.26 0.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20313 381
SS-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 397.64 beats/min 9.71 19.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17508 381
SS-Chr 15BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.3 breaths/min 6.96 22.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18269 381
SS-Chr 15BN/Mcwi absolute change in partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 -35.95 mmHg 5.75 8.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19470 381
SS-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during 2-3 min hypercapnia/control during standard conditions 305.61 % 36.39 102.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19215 381
SS-Chr 15BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.88 g/dl 0.07 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42237 401
SS-Chr 15BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 107.25 mmol/l 0.45 1.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39121 401
SS-Chr 15BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.5 mmol/l 0.58 1.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39391 401
SS-Chr 15BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 154.8 U/l 45.95 145.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42773 401
SS-Chr 15BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 17.2 mmol/l 1.0 3.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43157 401
SS-Chr 15BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42911 401
SS-Chr 15BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 14 149.9 g 6.1 22.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59066 526
SS-Chr 15BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 152.59 % 10.42 40.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53638 381
SS-Chr 15BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 179.38 % 19.2 54.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53639 381
SS-Chr 15BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 101.8 mmol/l 0.47 1.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40034 401
SS-Chr 15BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.69 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40433 401
SS-Chr 15BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.18 mmol/l 0.09 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43353 401
SS-Chr 15BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 3.86 mmol/l 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43355 401
SS-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 7 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59384 526
SS-Chr 15BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 119.1 U/l 39.24 124.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40717 401
SS-Chr 15BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 7.06 x 1000 cells/ul 0.45 1.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40929 401
SS-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 0.37 null 0.04 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59798 526
SS-Chr 15BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 109.1 mg/dl 2.37 7.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38461 401
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 92.52 mmHg 5.78 18.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45507 461
SS-Chr 15BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 33.23 % 4.75 15.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48530 461
SS-Chr 15BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 59.93 fl 0.21 0.68 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38675 401
SS-Chr 15BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.14 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41872 401
SS-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 7 -7.35 null 0.08 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55294 522
SS-Chr 15BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 44.16 % 0.56 1.76 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57515 526
SS-Chr 15BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.12 degrees C 0.2 0.62 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16576 381
SS-Chr 15BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 32.17 ml/min 2.49 9.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16693 381
SS-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -6.77 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55642 522
SS-Chr 15BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.34 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16476 381
SS-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.82 null 0.14 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56122 522
SS-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -8.42 null 0.23 0.71 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56124 522
SS-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 8 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58493 526
SS-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54925 522
SS-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.44 null 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58736 526
SS-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.72 null 0.1 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56932 522
SS-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -6.94 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56934 522
SS-Chr 15BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 27.3 mmHg 0.6 0.85 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16074 381
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 121.05 mmHg 9.5 28.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45733 461
SS-Chr 15BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.45 ml/min/g 0.36 1.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44721 461
SS-Chr 15BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.16 g/kg 0.17 0.53 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45633 461
SS-Chr 15BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 272.66 beats/min 10.56 33.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48200 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 60.9 mmHg 5.27 16.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46420 461
SS-Chr 15BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 82.86 % 3.78 11.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48298 461
SS-Chr 15BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 109.0 % 11.86 31.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48299 461
SS-Chr 15BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.23 ml 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15401 381
SS-Chr 15BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 135.04 mmHg 2.78 5.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15099 381
SS-Chr 15BN/Mcwi blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.45 null 0.05 0.12 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17053 381
SS-Chr 15BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 5.44 x 1000 cells/ul 0.46 1.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36895 401
SS-Chr 15BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 146.82 % 8.59 27.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13684 381
SS-Chr 15BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 96.85 mmHg 3.82 7.64 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18872 381
SS-Chr 15BN/Mcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 145.88 mmHg 5.94 11.89 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14337 381
SS-Chr 15BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 7 159.66 mmHg 5.64 14.91 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52847 482
SS-Chr 15BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 49.61 % 2.41 6.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47081 461
SS-Chr 15BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 7 139.22 mg/d 35.75 94.58 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52698 482
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 47.8 mmHg 3.19 8.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46421 461
SS-Chr 15BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.4 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17374 381
SS-Chr 15BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 193.2 g 3.1 9.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47830 461
SS-Chr 15BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 7 1.11 g/mg 0.19 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55807 522
SS-Chr 15BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 778.11 s 75.82 227.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49303 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 103.17 mmHg 9.1 28.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45508 461
SS-Chr 15BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 34.22 mmHg 3.05 9.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50001 461
SS-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during 2-3 min hypercapnia/control during standard conditions 237.57 % 19.55 75.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19214 381
SS-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 25.02 IU/g 2.1 6.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48875 461
SS-Chr 15BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.7 x 1000 cells/ul 0.08 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38922 401
SS-Chr 15BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.43 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38924 401
SS-Chr 15BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 105.9 breaths/min 10.62 30.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14939 381
SS-Chr 15BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 7 364.71 beats/min 8.9 23.56 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52649 482
SS-Chr 15BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 7 20.45 mEq/d 2.19 5.79 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52749 482
SS-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 3 0.38 mg/dl 0.04 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52209 482
SS-Chr 15BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.31 degrees C 0.15 0.57 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13562 381
SS-Chr 15BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 37.19 degrees C 0.24 0.68 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13563 381
SS-Chr 15BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 411.73 beats/min 19.27 38.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20926 381
SS-Chr 15BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 86.03 breaths/min 3.97 12.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18414 381
SS-Chr 15BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 2 344.65 beats/min 33.31 47.11 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14704 381
SS-Chr 15BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 -0.13 degrees C 0.14 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15672 381
SS-Chr 15BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 154.28 % 8.4 32.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54089 381
SS-Chr 15BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.29 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13926 381
SS-Chr 15BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.45 degrees C 0.2 0.78 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19072 381
SS-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during7-9 min hypercapnia/control during standard conditions 130.81 % 11.85 45.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18546 381
SS-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 443.27 beats/min 22.66 45.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17510 381
SS-Chr 15BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 238.1 beats/min 12.49 39.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48948 461
SS-Chr 15BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.9 g 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49063 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 4.99 mmHg 0.33 1.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49180 461
SS-Chr 15BN/Mcwi partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 58.78 mmHg 4.71 11.53 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20480 381
SS-Chr 15BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 878.1 s 63.67 201.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50123 461
SS-Chr 15BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1079.1 s 26.16 82.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50230 461
SS-Chr 15BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1007.22 s 72.86 218.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50231 461
SS-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 28.78 % 5.44 16.31 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49399 461
SS-Chr 15BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 66.9 U/l 2.98 9.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42445 401
SS-Chr 15BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 108.4 mmol/l 0.4 1.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39120 401
SS-Chr 15BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 21.5 mmol/l 0.5 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42066 401
SS-Chr 15BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.31 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42674 401
SS-Chr 15BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 133.95 % 8.35 26.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54331 381
SS-Chr 15BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42909 401
SS-Chr 15BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 231.8 g 5.3 16.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59065 526
SS-Chr 15BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.98 g/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40435 401
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.51 pg 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40224 401
SS-Chr 15BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 23.6 mg/dl 1.33 4.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40831 401
SS-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.17 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59550 526
SS-Chr 15BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 44.16 % 0.56 1.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41330 401
SS-Chr 15BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.06 g/dl 0.17 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37972 401
SS-Chr 15BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 5.05 mmol/l 0.15 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38069 401
SS-Chr 15BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 166.8 mg/dl 8.81 27.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41222 401
SS-Chr 15BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.62 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41055 401
SS-Chr 15BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 6.01 x 1000 cells/ul 0.34 1.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41506 401
SS-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.54 null 0.11 0.28 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59800 526
SS-Chr 15BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 20.7 mmol/l 1.02 3.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38264 401
SS-Chr 15BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41430 401
SS-Chr 15BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.0 mg/dl 0.54 1.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41778 401
SS-Chr 15BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 21.3 mg/dl 0.63 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41780 401
SS-Chr 15BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 155.25 mg/dl 14.8 41.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38534 401
SS-Chr 15BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 57.22 fl 0.2 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38673 401
SS-Chr 15BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 7.37 x 10E6 cells/ul 0.09 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41997 401
SS-Chr 15BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.98 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45409 461
SS-Chr 15BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 999.3 s 32.31 102.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46551 461
SS-Chr 15BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 28.66 ml/min 3.27 12.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16150 381
SS-Chr 15BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 215.0 g 4.2 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55199 522
SS-Chr 15BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.77 g/mg 0.11 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55805 522
SS-Chr 15BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 194.1 g 3.0 9.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58366 526
SS-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 73.63 % 6.48 18.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54797 522
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.09 mg/kg 0.23 0.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58909 526
SS-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.11 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59914 526
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 15.25 ml/min/kg 1.59 3.89 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60022 526
SS-Chr 15BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 87.53 mmHg 5.9 18.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46753 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 10.42 ml/min/g 0.7 2.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46874 461
SS-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 66.03 % 5.19 15.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46069 461
SS-Chr 15BN/Mcwi absolute change in partial pressure of blood carbon dioxide air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 -6.62 mmHg 1.18 2.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19637 381
SS-Chr 15BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 61.57 ml/min 4.28 16.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14503 381
SS-Chr 15BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 178.29 breaths/min 10.08 28.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16915 381
SS-Chr 15BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.14 breaths/min 5.97 18.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14798 381
SS-Chr 15BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 7 0.99 mEq/d 0.14 0.36 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52946 482
SS-Chr 15BN/Mcwi absolute change in blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 0.05 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19791 381
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.26 mmHg 0.17 0.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47200 461
SS-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 208.68 beats/min 8.81 23.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45152 461
SS-Chr 15BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 33.01 mmHg 4.72 14.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45273 461
SS-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.39 IU/g 0.05 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47324 461
SS-Chr 15BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 10 158.8 g 3.2 10.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47832 461
SS-Chr 15BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 48.02 mmHg 6.3 19.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47914 461
SS-Chr 15BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 46.7 mmHg 3.45 10.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48036 461
SS-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -7.08 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55644 522
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.79 g/dl 0.17 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39781 401
SS-Chr 15BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 4.82 x 1000 cells/ul 0.17 0.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39913 401
SS-Chr 15BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41871 401
SS-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54923 522
SS-Chr 15BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 828.8 s 25.2 79.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50122 461
SS-Chr 15BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 56.86 % 0.74 2.1 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59261 526
SS-Chr 15BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 39.75 U/l 3.4 9.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40718 401
SS-Chr 15BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 24.08 ml/min 2.61 7.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16151 381
SS-Chr 15BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 42.2 U/l 2.9 9.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37735 401
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 21.33 ml/min/kg 1.88 5.32 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57804 526
SS-Chr 15BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 17.92 g/dl 0.25 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37971 401