Phenominer Database Results (407 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 14BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 67.3 ml/min 3.97 12.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14532 381
SS-Chr 14BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 407.86 beats/min 8.54 22.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15905 381
SS-Chr 14BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 125.98 mmHg 3.04 8.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19843 381
SS-Chr 14BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 421.61 beats/min 8.76 23.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20897 381
SS-Chr 14BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 87.84 breaths/min 3.83 13.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18447 381
SS-Chr 14BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 20 73.25 mg/dl 2.17 9.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37133 401
SS-Chr 14BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 6.06 g/dl 0.06 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37187 401
SS-Chr 14BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 96.24 mmHg 1.73 4.9 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18848 381
SS-Chr 14BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 127.99 mmHg 3.61 9.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15068 381
SS-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.65 breaths/min 6.47 20.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14826 381
SS-Chr 14BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 124.97 mmHg 2.86 7.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13462 381
SS-Chr 14BN/Mcwi post-insult time to mammary tumor formation 7,12-dimethyltetraphene (DMBA) (65 mg/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152 days-162 days 14 46.69 d 1.09 4.06 manual palpation method 0 DMBA oral gavage 105 days 200 mg DMBA in 10 ml seame oil 65570 86
SS-Chr 14BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 160.06 breaths/min 6.89 21.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16943 381
SS-Chr 14BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.47 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20604 381
SS-Chr 14BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 140.6 U/l 14.81 46.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37439 401
SS-Chr 14BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 7.06 x 1000 cells/ul 0.31 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36865 401
SS-Chr 14BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 20 9.24 mg/dl 0.11 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36660 401
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 396.78 beats/min 5.64 16.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17484 381
SS-Chr 14BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 144.0 mmol/l 0.52 1.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36479 401
SS-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 37.35 ml/min 1.47 5.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20245 381
SS-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 15.64 % 3.32 10.5 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49428 461
SS-Chr 14BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 69.5 U/l 4.19 13.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42406 401
SS-Chr 14BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 17 3.76 g/dl 0.03 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42265 401
SS-Chr 14BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 17 108.0 mmol/l 0.45 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39149 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 19.19 pg 0.08 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42581 401
SS-Chr 14BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.29 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42642 401
SS-Chr 14BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 17 8.83 x 10E6 cells/ul 0.09 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39269 401
SS-Chr 14BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 17 0.2 x 1000 cells/ul 0.05 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39706 401
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 136.71 % 7.86 27.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54363 381
SS-Chr 14BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 21.3 mmol/l 0.4 1.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43127 401
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 19 0.91 mg/kg 0.09 0.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58942 526
SS-Chr 14BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.51 x 1000 cells/ul 0.04 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40290 401
SS-Chr 14BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 17 6.29 x 1000 cells/ul 0.32 1.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40958 401
SS-Chr 14BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 20 1.26 g/kg 0.04 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59693 526
SS-Chr 14BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 0.93 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59450 526
SS-Chr 14BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 51.7 U/l 3.6 11.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37703 401
SS-Chr 14BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 20 5.65 x 1000 cells/ul 0.43 1.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41539 401
SS-Chr 14BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 17 19.29 mmol/l 0.79 3.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38293 401
SS-Chr 14BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 17.4 mg/dl 0.97 3.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41748 401
SS-Chr 14BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 17 0.11 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41900 401
SS-Chr 14BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 58.83 fl 0.47 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38636 401
SS-Chr 14BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 57.07 fl 0.31 0.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38643 401
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 121.3 mmHg 7.7 17.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45536 461
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 262.63 beats/min 6.79 28.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47614 461
SS-Chr 14BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.42 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16505 381
SS-Chr 14BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.5 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16510 381
SS-Chr 14BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.03 degrees C 0.36 1.24 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16609 381
SS-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 9 0.22 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57897 526
SS-Chr 14BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 188.1 g 9.1 28.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58327 526
SS-Chr 14BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 12 36.6 degrees C 0.36 1.24 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16849 381
SS-Chr 14BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.48 null 0.2 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56092 522
SS-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.14 umol/l 0.04 0.11 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54654 522
SS-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 19 0.03 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58521 526
SS-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 18 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58525 526
SS-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 81.17 % 5.9 14.44 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57204 522
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 120.95 mmHg 7.74 15.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46782 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 113.89 mmHg 10.91 18.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46786 461
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 37.61 mmHg 2.92 8.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47737 461
SS-Chr 14BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 184.6 g 15.7 49.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47800 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.24 IU/g 0.05 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47293 461
SS-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 112.84 % 7.22 22.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44950 461
SS-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 66.92 % 6.1 10.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46355 461
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 92.53 mmHg 9.53 28.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44851 461
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 255.2 beats/min 15.17 64.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45184 461
SS-Chr 14BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 79.37 % 3.31 9.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48442 461
SS-Chr 14BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 0.8 g 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49092 461
SS-Chr 14BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 64.94 ml/min 3.57 11.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20793 381
SS-Chr 14BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 79.21 ml/min 3.82 13.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20798 381
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 106.36 % 4.54 15.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54023 381
SS-Chr 14BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 127.89 mmHg 2.13 6.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15073 381
SS-Chr 14BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.24 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15429 381
SS-Chr 14BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 10 190.9 g 3.5 11.2 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17849 381
SS-Chr 14BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 12 36.88 degrees C 0.12 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19106 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 134.85 % 7.27 25.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18580 381
SS-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13955 381
SS-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.37 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13960 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during 2-3 min hypercapnia/control during standard conditions 321.56 % 16.57 57.4 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19248 381
SS-Chr 14BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 94.28 % 4.85 20.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48331 461
SS-Chr 14BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 5.5 g/kg 0.27 1.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45603 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 6.25 ml/min/g 0.4 1.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44754 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 54.91 mmHg 8.62 25.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47947 461
SS-Chr 14BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 51.41 mmHg 8.14 25.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48065 461
SS-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 0.52 null 0.02 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58145 526
SS-Chr 14BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 43.56 ml/min/kg 3.83 11.49 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58216 526
SS-Chr 14BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 20 0.2 x 1000 cells/ul 0.04 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39710 401
SS-Chr 14BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42872 401
SS-Chr 14BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 16 853.88 s 25.32 101.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49331 461
SS-Chr 14BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 17 0.58 x 1000 cells/ul 0.06 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43256 401
SS-Chr 14BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 28.52 ml/min 1.95 6.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16727 381
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 52.62 mmHg 2.59 11.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46453 461
SS-Chr 14BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 0.82 g 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45437 461
SS-Chr 14BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 1071.53 s 28.17 122.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50263 461
SS-Chr 14BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 17 39.47 U/l 1.58 6.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40746 401
SS-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 105.23 % 7.65 33.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48792 461
SS-Chr 14BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 21.31 ml/min 1.31 4.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16179 381
SS-Chr 14BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 26.64 ml/min 2.05 7.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16184 381
SS-Chr 14BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 89.01 breaths/min 4.02 13.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14972 381
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 115.4 % 6.42 20.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54019 381
SS-Chr 14BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 11 70.08 mg/d 9.98 33.11 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52682 482
SS-Chr 14BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 8 176.19 mmHg 8.36 23.66 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52835 482
SS-Chr 14BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 11 0.88 mEq/d 0.09 0.29 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52929 482
SS-Chr 14BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 9 0.3 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52192 482
SS-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 11 27.35 mg/d 3.58 11.87 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52582 482
SS-Chr 14BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 8 389.33 beats/min 13.3 37.62 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52637 482
SS-Chr 14BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 125.85 mmHg 3.53 10.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13466 381
SS-Chr 14BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 123.72 mmHg 2.94 8.82 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19847 381
SS-Chr 14BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 395.63 beats/min 4.54 13.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20902 381
SS-Chr 14BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 88.38 breaths/min 2.9 9.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18442 381
SS-Chr 14BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 203.0 U/l 8.44 26.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37446 401
SS-Chr 14BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -42.27 mmHg 1.55 4.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19444 381
SS-Chr 14BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 799.7 s 38.73 122.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50155 461
SS-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 15 11.88 % 2.27 8.78 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49730 461
SS-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 19 18.05 % 2.18 9.5 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49734 461
SS-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 52.83 % 0.8 3.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39027 401
SS-Chr 14BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.53 x 1000 cells/ul 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38885 401
SS-Chr 14BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 20 70.8 U/l 3.33 14.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42806 401
SS-Chr 14BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 8.85 x 10E6 cells/ul 0.13 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39273 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 19.4 pg 0.11 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42577 401
SS-Chr 14BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 17 0.29 mg/dl 0.02 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39608 401
SS-Chr 14BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 19 0.31 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39612 401
SS-Chr 14BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 22.2 mmol/l 0.47 1.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42986 401
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 120.79 % 8.02 25.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54359 381
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 180.94 % 8.25 26.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53667 381
SS-Chr 14BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 13.94 g/dl 0.15 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40091 401
SS-Chr 14BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 20 48.4 U/l 1.91 8.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40750 401
SS-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 20 52.83 % 0.8 3.57 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59293 526
SS-Chr 14BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 20 22.45 mg/dl 0.88 3.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40864 401
SS-Chr 14BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 17 2.16 g/dl 0.07 0.3 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40582 401
SS-Chr 14BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 20 9.49 mg/dl 0.29 1.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37630 401
SS-Chr 14BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.14 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59443 526
SS-Chr 14BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41393 401
SS-Chr 14BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 9.37 mg/dl 0.2 0.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37823 401
SS-Chr 14BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 20 0.0 x 1000 cells/ul 0.0 0.01 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41683 401
SS-Chr 14BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 18.2 mg/dl 0.88 2.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41741 401
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 273.59 beats/min 10.1 44.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47618 461
SS-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 30.25 % 5.26 17.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48563 461
SS-Chr 14BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.01 null 0.12 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55255 522
SS-Chr 14BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.81 null 0.05 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55612 522
SS-Chr 14BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 43.36 ml/min/kg 2.24 6.34 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58223 526
SS-Chr 14BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 -7.62 null 0.18 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56085 522
SS-Chr 14BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 297.3 g 8.3 26.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55171 522
SS-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.1 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59884 526
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 42.07 mmHg 5.2 16.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47733 461
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 111.98 mmHg 4.67 14.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44847 461
SS-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 59.4 % 3.47 15.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47113 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 10.55 ml/min/g 2.67 8.46 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46233 461
SS-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 90.04 % 16.21 51.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46098 461
SS-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 74.79 % 1.99 5.97 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46102 461
SS-Chr 14BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 267.31 beats/min 10.56 33.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48229 461
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 4.97 mmHg 0.26 0.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49209 461
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 177.63 % 7.29 23.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54118 381
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 173.05 % 8.68 27.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54252 381
SS-Chr 14BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 124.12 mmHg 2.89 8.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14311 381
SS-Chr 14BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 101.4 mmHg 1.39 3.41 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18844 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 153.25 % 12.3 38.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13712 381
SS-Chr 14BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 6 27.25 mmHg 0.48 1.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17218 381
SS-Chr 14BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 30.94 mmHg 0.75 2.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17223 381
SS-Chr 14BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.86 mg/dl 0.08 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36755 401
SS-Chr 14BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 7 1.79 ml/min 0.18 0.47 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52147 482
SS-Chr 14BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19761 381
SS-Chr 14BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 302.85 beats/min 7.64 24.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48233 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 9.9 ml/min/g 0.61 2.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46685 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.38 ml/min/g 1.05 3.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46902 461
SS-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.14 g/mg 0.2 0.63 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55768 522
SS-Chr 14BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 17 151.94 mg/dl 8.46 34.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38562 401
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 17 0.82 mg/kg 0.1 0.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58938 526
SS-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 62.56 % 6.52 19.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54767 522
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 21.51 ml/min/kg 1.2 3.4 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58619 526
SS-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 22 173.1 g 2.8 13.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59094 526
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 18.07 ml/min/kg 0.7 2.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57630 526
SS-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 17 53.46 % 0.75 3.1 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59289 526
SS-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 17 53.48 % 0.75 3.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39023 401
SS-Chr 14BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 20 108.25 mmol/l 0.41 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39153 401
SS-Chr 14BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 153.7 mg/dl 3.9 12.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41183 401
SS-Chr 14BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 2.33 g/dl 0.09 0.28 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41016 401
SS-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15270 381
SS-Chr 14BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 84.08 ml/min 5.32 18.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14537 381
SS-Chr 14BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 9 0.87 ng/ml/h 0.09 0.27 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52437 482
SS-Chr 14BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 11 11.05 mEq/d 2.27 7.51 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52733 482
SS-Chr 14BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 124.55 mmHg 3.93 10.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14306 381
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 113.05 % 3.16 10.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53922 381
SS-Chr 14BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 17 5.92 g/dl 0.07 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36994 401
SS-Chr 14BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 20 202.25 U/l 12.03 53.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36415 401
SS-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 42.68 ml/min 2.09 7.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18699 381
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.71 g/dl 0.1 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37317 401
SS-Chr 14BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.56 degrees C 0.2 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19101 381
SS-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 117.73 breaths/min 5.19 17.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18302 381
SS-Chr 14BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 20 19.6 mmol/l 0.68 3.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42098 401
SS-Chr 14BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.26 mg/dl 0.06 0.19 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42635 401
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 169.38 % 5.83 20.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54462 381
SS-Chr 14BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42879 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.6 pg 0.11 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40194 401
SS-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 20 233.5 g 6.1 27.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59098 526
SS-Chr 14BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.73 g/dl 0.07 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40396 401
SS-Chr 14BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 13.76 g/dl 0.11 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40098 401
SS-Chr 14BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 17.15 g/dl 0.24 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38000 401
SS-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.52 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59762 526
SS-Chr 14BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.86 mg/dl 0.31 0.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37816 401
SS-Chr 14BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 2.38 g/dl 0.08 0.26 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41023 401
SS-Chr 14BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 16 4.51 mmol/l 0.12 0.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38098 401
SS-Chr 14BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 96.4 mg/dl 2.39 7.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38422 401
SS-Chr 14BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 20 19.85 mmol/l 0.9 4.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38297 401
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 118.46 mmHg 10.8 18.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45540 461
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 22.73 ml/min/kg 0.84 3.57 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57836 526
SS-Chr 14BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -6.92 null 0.12 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55262 522
SS-Chr 14BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 42.22 % 0.4 1.26 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57483 526
SS-Chr 14BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 19 57.13 ml/min/kg 2.77 12.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58031 526
SS-Chr 14BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 190.1 g 2.7 8.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55399 522
SS-Chr 14BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.28 degrees C 0.12 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16604 381
SS-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.17 umol/l 0.05 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54661 522
SS-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 20 0.33 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58769 526
SS-Chr 14BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -6.76 null 0.08 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56895 522
SS-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.2 ml/min/g 0.6 1.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46906 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 7.53 ml/min/g 0.51 1.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46237 461
SS-Chr 14BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 89.43 % 5.03 15.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48438 461
SS-Chr 14BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.43 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20600 381
SS-Chr 14BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 56.4 mmHg 1.98 4.85 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20451 381
SS-Chr 14BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 53.97 mmHg 0.86 2.43 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20456 381
SS-Chr 14BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 237.85 beats/min 14.13 44.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48977 461
SS-Chr 14BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 241.99 beats/min 10.89 32.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48981 461
SS-Chr 14BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.9 g 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49096 461
SS-Chr 14BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.08 degrees C 0.2 0.63 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15701 381
SS-Chr 14BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.18 degrees C 0.11 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13596 381
SS-Chr 14BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 6.02 g/dl 0.06 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37194 401
SS-Chr 14BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 154.5 % 9.92 34.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13717 381
SS-Chr 14BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 7 1.17 mEq/d 0.12 0.33 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52933 482
SS-Chr 14BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 9 152.32 mmHg 5.38 16.15 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52831 482
SS-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 110.06 breaths/min 3.63 12.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14831 381
SS-Chr 14BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 7 52.06 mg/d 8.09 21.4 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52586 482
SS-Chr 14BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 9 416.82 beats/min 7.99 23.98 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52633 482
SS-Chr 14BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 35.02 mmHg 0.48 1.18 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16046 381
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 45.17 mmHg 6.1 23.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45302 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 0.31 IU/g 0.04 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47428 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 27.87 IU/g 2.62 11.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45959 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 8.0 ml/min/g 1.54 5.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44750 461
SS-Chr 14BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 17 5.47 x 1000 cells/ul 0.29 1.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41535 401
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 4.91 mmHg 0.35 0.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49213 461
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.25 pg 0.17 0.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40187 401
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 44.4 mmHg 3.32 12.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46449 461
SS-Chr 14BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 1098.5 s 34.35 137.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50259 461
SS-Chr 14BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 967.6 s 27.39 86.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46580 461
SS-Chr 14BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 725.7 s 70.55 223.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50151 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 29.5 IU/g 2.65 8.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48844 461
SS-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59877 526
SS-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 0.86 g/mg 0.11 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57321 522
SS-Chr 14BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 16.99 g/dl 0.26 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38004 401
SS-Chr 14BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 17 142.76 mmol/l 0.45 1.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39420 401
SS-Chr 14BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 8 0.37 mg/dl 0.03 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52196 482
SS-Chr 14BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 7 13.1 mEq/d 1.27 3.35 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52737 482
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 127.84 % 6.45 22.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53790 381
SS-Chr 14BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.04 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19765 381
SS-Chr 14BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.51 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17029 381
SS-Chr 14BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 17 117.94 U/l 4.39 18.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36411 401
SS-Chr 14BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 17 79.06 mg/dl 1.68 6.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37129 401
SS-Chr 14BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.3 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15434 381
SS-Chr 14BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 152.46 breaths/min 5.59 17.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17143 381
SS-Chr 14BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -7.77 mmHg 0.38 0.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19611 381
SS-Chr 14BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.26 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18014 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 150.8 % 12.42 39.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18575 381
SS-Chr 14BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 5.85 x 1000 cells/ul 0.44 1.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36858 401
SS-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 105.33 breaths/min 4.8 15.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18297 381
SS-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 22.77 % 3.22 9.65 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49432 461
SS-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 20 139.5 g 4.1 18.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49498 461
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 89.57 mmHg 7.05 27.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49920 461
SS-Chr 14BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 16 38.69 mmHg 4.18 16.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50029 461
SS-Chr 14BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 19 39.42 mmHg 3.16 13.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50033 461
SS-Chr 14BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 20 3.39 g/dl 0.05 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42269 401
SS-Chr 14BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 17 20.12 mmol/l 0.7 2.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42094 401
SS-Chr 14BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 17 58.81 fl 1.7 7.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38777 401
SS-Chr 14BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 20 59.66 fl 0.21 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38781 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 32.04 g/dl 0.09 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39809 401
SS-Chr 14BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 20 0.76 x 1000 cells/ul 0.09 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43260 401
SS-Chr 14BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 105.7 mmol/l 0.52 1.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39995 401
SS-Chr 14BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.64 g/dl 0.05 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40403 401
SS-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59347 526
SS-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 7 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59354 526
SS-Chr 14BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 20 6.66 x 1000 cells/ul 0.49 2.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40962 401
SS-Chr 14BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 20 2.21 g/dl 0.08 0.34 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40586 401
SS-Chr 14BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 51.7 U/l 4.75 15.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37696 401
SS-Chr 14BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 158.3 mg/dl 3.94 12.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41190 401
SS-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59583 526
SS-Chr 14BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 19 5.04 mmol/l 0.18 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38102 401
SS-Chr 14BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 42.22 % 0.4 1.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41298 401
SS-Chr 14BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 7.23 x 10E6 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41958 401
SS-Chr 14BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 0.92 g 0.04 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45441 461
SS-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 34.68 % 5.82 18.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48559 461
SS-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 1.3 g/mg 0.18 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57314 522
SS-Chr 14BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 42.54 % 0.4 1.27 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57476 526
SS-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 91.84 % 7.96 30.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48788 461
SS-Chr 14BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 -7.04 null 0.12 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55605 522
SS-Chr 14BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 22.86 ml/min 1.62 5.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16722 381
SS-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.54 null 0.03 0.14 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58149 526
SS-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 1.61 E-7mole 0.19 0.54 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55881 522
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 22.89 ml/min/kg 2.41 7.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58612 526
SS-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.39 E-7mole 0.23 0.7 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56507 522
SS-Chr 14BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 36.06 mmHg 0.65 1.84 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16050 381
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 104.88 mmHg 5.94 20.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45761 461
SS-Chr 14BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 5.09 g/kg 0.22 0.7 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46971 461
SS-Chr 14BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 5.26 g/kg 0.59 1.86 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46978 461
SS-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 74.12 % 8.26 18.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46351 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.07 IU/g 0.03 0.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47286 461
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 241.21 beats/min 17.93 67.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45180 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 40.83 mmHg 4.77 20.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45306 461
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 126.5 % 3.92 12.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53918 381
SS-Chr 14BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -5.12 mmHg 0.74 2.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19615 381
SS-Chr 14BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 168.77 breaths/min 5.32 18.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16948 381
SS-Chr 14BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.48 degrees C 0.11 0.35 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13591 381
SS-Chr 14BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 397.58 beats/min 10.68 28.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14675 381
SS-Chr 14BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 12 300.8 g 9.7 33.5 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17854 381
SS-Chr 14BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 143.9 mmol/l 0.35 1.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36486 401
SS-Chr 14BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 17 9.04 mg/dl 0.09 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36656 401
SS-Chr 14BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 8 0.42 ng/ml/h 0.1 0.29 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52441 482
SS-Chr 14BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.43 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17402 381
SS-Chr 14BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 89.9 % 5.4 20.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48327 461
SS-Chr 14BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 10 158.8 g 4.0 12.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47793 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 26.61 IU/g 2.95 11.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45955 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 69.91 mmHg 7.47 23.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47943 461
SS-Chr 14BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 22.1 mmol/l 0.46 1.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42979 401
SS-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 20 169.3 g 7.0 31.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49505 461
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 180.75 % 10.12 32.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54458 381
SS-Chr 14BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 6.71 x 1000 cells/ul 0.52 1.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39874 401
SS-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 6 1.08 E-7mole 0.23 0.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55874 522
SS-Chr 14BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 20 0.11 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41904 401
SS-Chr 14BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 5.99 g/kg 0.21 0.89 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45596 461
SS-Chr 14BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 76.1 U/l 2.92 9.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42413 401
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 31.97 IU/g 4.89 14.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48848 461
SS-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.5 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59769 526
SS-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 19 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59579 526
SS-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.21 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57890 526
SS-Chr 14BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 88.86 breaths/min 2.42 7.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14967 381
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 166.92 % 4.25 14.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54122 381
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 180.7 % 7.38 25.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54256 381
SS-Chr 14BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.33 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18019 381
SS-Chr 14BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 358.13 beats/min 8.61 25.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14679 381
SS-Chr 14BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 399.16 beats/min 8.12 24.37 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15909 381
SS-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.3 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15265 381
SS-Chr 14BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 7 151.26 mg/d 29.91 79.13 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52686 482
SS-Chr 14BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 9 1.62 ml/min 0.21 0.64 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52143 482
SS-Chr 14BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 158.19 breaths/min 3.78 13.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17148 381
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 129.95 % 6.19 19.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53786 381
SS-Chr 14BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17024 381
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.6 g/dl 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37324 401
SS-Chr 14BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.85 mg/dl 0.13 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36748 401
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 436.17 beats/min 14.55 38.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17479 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 320.66 % 18.42 58.25 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19243 381
SS-Chr 14BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -45.0 mmHg 2.36 5.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19440 381
SS-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 34.34 ml/min 3.52 11.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20240 381
SS-Chr 14BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.14 degrees C 0.27 0.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20341 381
SS-Chr 14BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 0.43 degrees C 0.14 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20346 381
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 93.45 mmHg 5.56 24.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49924 461
SS-Chr 14BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 20 142.55 mmol/l 0.59 2.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39424 401
SS-Chr 14BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 16 70.69 U/l 4.22 16.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42802 401
SS-Chr 14BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 20.3 mmol/l 0.58 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43120 401
SS-Chr 14BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 8.35 x 1000 cells/ul 0.38 1.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39881 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 32.16 g/dl 0.1 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39813 401
SS-Chr 14BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 3.92 mmol/l 0.11 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43316 401
SS-Chr 14BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.26 mmol/l 0.1 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43323 401
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.14 mg/kg 0.14 0.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59161 526
SS-Chr 14BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 104.7 mmol/l 0.37 1.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40002 401
SS-Chr 14BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 22 1.44 g/kg 0.04 0.2 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59689 526
SS-Chr 14BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 91.3 mg/dl 1.62 5.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38429 401
SS-Chr 14BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 19 158.95 mg/dl 6.43 28.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38566 401
SS-Chr 14BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 7.4 x 10E6 cells/ul 0.06 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41965 401
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 99.02 mmHg 6.6 21.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48656 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 99.17 mmHg 6.66 22.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48660 461
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 29.19 ml/min/kg 0.92 3.91 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57832 526
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 15.01 ml/min/kg 0.42 1.79 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57634 526
SS-Chr 14BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 1.03 g/mg 0.14 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55775 522
SS-Chr 14BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 274.8 g 9.1 28.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55405 522
SS-Chr 14BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 43.7 ml/min/kg 1.92 7.92 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58035 526
SS-Chr 14BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 268.8 g 8.4 26.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58334 526
SS-Chr 14BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.42 degrees C 0.23 0.72 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16844 381
SS-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 80.75 % 5.67 16.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54760 522
SS-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 8 0.04 umol/l 0.02 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54886 522
SS-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 22 0.35 null 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58765 526
SS-Chr 14BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 178.5 g 5.3 16.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55165 522
SS-Chr 14BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -6.82 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56902 522
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 12 101.63 mmHg 6.75 23.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45765 461
SS-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 65.55 % 4.53 16.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47109 461
SS-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 113.53 % 11.69 35.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44954 461
SS-Chr 14BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 0.3 degrees C 0.11 0.4 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15706 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 310.42 % 18.22 57.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14230 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 305.65 % 15.58 53.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14235 381
SS-Chr 14BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 20 5.6 g/dl 0.11 0.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36998 401
SS-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 34.44 ml/min 2.87 9.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18694 381
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 18 5.39 mmHg 0.25 1.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47233 461
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 5.78 mmHg 0.16 0.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47229 461
SS-Chr 14BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 78.25 % 5.32 15.05 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57211 522
SS-Chr 14BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.5 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17407 381
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 0.35 IU/g 0.05 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47435 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 10.65 ml/min/g 0.51 2.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46689 461
SS-Chr 14BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 43.2 mmHg 4.57 14.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48069 461
SS-Chr 14BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.08 umol/l 0.03 0.09 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54893 522
SS-Chr 14BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 994.4 s 31.81 100.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46584 461
SS-Chr 14BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.3 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40283 401
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 0.65 mg/kg 0.06 0.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59154 526
SS-Chr 14BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 1.96 E-7mole 0.45 1.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56500 522
SS-Chr 14BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 17 21.47 mg/dl 0.87 3.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40860 401
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 12.62 ml/min/kg 1.57 4.7 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59983 526
SS-Chr 14BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.79 x 1000 cells/ul 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38892 401
SS-Chr 14BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 8.81 mg/dl 0.22 0.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37626 401
SS-Chr 14BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 42.54 % 0.4 1.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41291 401
SS-Chr 14BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41400 401
SS-Chr 14BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 19 852.26 s 22.54 98.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49335 461
SS-Chr 14BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 17 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41679 401
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 193.71 % 10.63 36.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53671 381
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 13.1 ml/min/kg 0.56 1.6 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59990 526