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Strain
Phenotype
Conditions
Study
Experiment Name
Sex
Age
# of Animals
Value
Units
SEM
SD
Individual Records
Method
Method Duration
Post Insult Time Value
Experiment Notes
Record ID
Study ID
WKY/NCrl
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)
PhysGen Vascular data
vasodilation trait
female
70 days-84 days
8
-7.47
null
0.2
0.56
Download Values
wire myography using a Digi-Med tissue force analysis system with force transducer
0
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan
54750
522
WKY/NCrl
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)
PhysGen Vascular data
vasodilation trait
male
70 days-84 days
15
-7.45
null
0.09
0.33
Download Values
wire myography using a Digi-Med tissue force analysis system with force transducer
0
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan
56772
522
WKY/NCrl
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
salidroside (40 mg/kg) (for 28 days)
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.
vasodilation trait
male
168 days
7
-7.72
null
0.03
0.08
wire myography
0.0
0
103603
2827
WKY/NCrl
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
salidroside (40 mg/kg) (for 28 days)
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.
vasodilation trait
male
168 days
7
-7.1
null
0.04
0.11
wire myography
0
103587
2827
WKY/NCrl
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)
PhysGen Vascular data
vasodilation trait
male
70 days-84 days
12
-7.4
null
0.12
0.4
Download Values
wire myography using a Digi-Med tissue force analysis system with force transducer
0
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan
54743
522
WKY/NCrl
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)
PhysGen Vascular data
vasodilation trait
female
70 days-84 days
18
-7.63
null
0.06
0.27
Download Values
wire myography using a Digi-Med tissue force analysis system with force transducer
0
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan
56779
522
WKY/NCrl
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
vehicle control condition (for 28 days)
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.
vasodilation trait
male
168 days
7
-7.07
null
0.05
0.14
wire myography
0
103586
2827
WKY/NCrl
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
vehicle control condition (for 28 days)
Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.
vasodilation trait
male
168 days
7
-7.6
null
0.05
0.13
wire myography
0.0
0
103602
2827