Phenominer Database Results (209 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Record ID Study ID
LH/Mav systolic blood pressure control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. arterial blood pressure trait male 112 days 4 undefined 157.0 mmHg 7.0 14.0 tail cuff plethysmography 0.0 0 102809 2723
LH/Mav urine total protein excretion rate control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. total urine protein amount male 112 days 8 182.0 mg/d 24.0 67.88 urine protein analysis 0.0 0 102810 2723
LH/Mav urine total protein excretion rate control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. total urine protein amount male 161 days 4 370.0 mg/d 32.0 64.0 urine protein analysis 0.0 0 102813 2723
LH/Mav systolic blood pressure perindopril (1.5 mg/kg/d) (for 42 days) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. arterial blood pressure trait male 63 days 7 undefined 113.0 mmHg 3.0 7.94 tail cuff plethysmography 0.0 0 102850 2761
LH/Mav renal vascular resistance to kidney weight ratio nifedipine (50 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. kidney blood vessel physiology trait male 84 days 7 SBP/RBF 37.0 ml/min/g/mmHg 5.0 13.23 ultrasonic flowmeter 0.0 0 102868 2761
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. heart left ventricle mass male 112 days 14 2.25 mg/g 0.0 0.01 post excision weight measurement 0.0 0 102769 2721
LH/Mav body weight vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 112 days 11 384.0 g 9.0 29.85 body weighing method 0.0 0 102724 2721
LH/Mav body weight streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 112 days 14 388.0 g 5.0 18.71 body weighing method 0.0 0 102725 2721
LH/Mav urine sodium excretion rate to body weight ratio controlled perindopril content drinking water (3 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. urine sodium amount male 147 days-154 days 6 0.0 uEq/min/g 0.0 0.0 flame photometry 0.0 0 103467 2825
LH/Mav heart left ventricle weight to body weight ratio control condition (for 0 hours) Cerutti C, et al., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1. heart left ventricle mass male 84 days 5 2.43 mg/g 0.08 0.18 post excision weight measurement 0.0 0 103485 2826
LH/Mav body weight perindopril (0.04 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 161 days 8 442.0 g 6.0 16.97 body weighing method 0.0 0 102802 2723
LH/Mav body weight controlled perindopril content drinking water (1.5 mg/kg/d) (for 63 days) then controlled sodium chloride content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. body mass male 119 days 8 380.0 g 10.0 28.28 body weighing method 0.0 0 103406 2824
LH/Mav diastolic blood pressure controlled losartan content drinking water (10 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 147 days-154 days 5 2hr mean (10a-12p) continuous mean 111.0 mmHg 3.0 6.71 vascular fluid filled catheter 0.0 0 103441 2825
LH/Mav diastolic blood pressure controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 147 days-154 days 6 2hr mean (10a-12p) continuous mean 121.0 mmHg 4.0 9.8 vascular fluid filled catheter 0.0 0 103443 2825
LH/Mav urine total protein excretion rate control condition (between 147 and 154 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. total urine protein amount male 147 days-154 days 6 241.0 mg/d 26.0 63.69 urine protein colorimetric analysis 0.0 0 103448 2825
LH/Mav blood glucose level streptozotocin (75 mg/kg) then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 14 358.0 mg/dl 11.0 41.16 blood glucose analysis 0.0 0 102721 2721
LH/Mav systolic blood pressure streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 112 days 14 mean of 3 samples of undefined duration serial mean 179.0 mmHg 4.0 14.97 tail cuff plethysmography 0.0 0 102729 2721
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood cholesterol amount male 112 days 14 116.22 mg/dl 4.25 15.89 plasma total cholesterol measurement test 0.0 0 102753 2721
LH/Mav plasma triglyceride level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood triglyceride amount male 112 days 11 1.43 mmol/l 0.16 0.53 plasma triglyceride analysis 0.0 0 102756 2721
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 11 73.36 mg/dl 4.63 15.37 blood cholesterol analysis 0.0 0 102666 2703
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 7 24.2 mg/g 0.3 0.79 post excision weight measurement 0.0 0 102685 2703
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 8 13.5 mg/100g 0.5 1.41 post excision weight measurement 0.0 0 102688 2703
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 7 12.5 mg/100g 0.5 1.32 post excision weight measurement 0.0 0 102691 2703
LH/Mav systolic blood pressure streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 56 days 14 mean of 3 samples of undefined duration serial mean 148.0 mmHg 4.0 14.97 tail cuff plethysmography 0.0 0 102705 2721
LH/Mav body weight perindopril (0.04 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 112 days 8 394.0 g 4.0 11.31 body weighing method 0.0 0 102788 2723
LH/Mav urine total protein excretion rate to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. total urine protein amount male 161 days 10 57.68 mg/d/100 g 4.34 13.72 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 102045 2645
LH/Mav urine sodium level to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 14 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 175 days 10 0.45 mmol/l/100g 0.02 0.06 flame photometry 0.0 0 102061 2645
LH/Mav mean arterial blood pressure right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 112 days 8 146.0 mmHg 5.0 14.14 vascular fluid filled catheter 0.0 0 104573 2970
LH/Mav renal blood flow rate right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 112 days 8 8.7 ml/min/g 0.6 1.7 ultrasonic flowmeter 0.0 0 104579 2970
LH/Mav glomerular filtration rate to kidney weight ratio right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 112 days 8 0.99 ml/min/g 0.08 0.23 ultrasonic flowmeter 0.0 0 104591 2970
LH/Mav renal blood flow rate right nephrectomy (between 9 and 10 days) then left kidney denervation then polyfructosan (1.25 %) (for 1.5 hours) and 0.9% sodium chloride solution (330 ul/kg/min) (for 1.5 hours) and bovine serum albumin (1 %) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 112 days 9 10.2 ml/min/g 0.3 0.9 ultrasonic flowmeter 0.0 0 104599 2970
LH/Mav glomerular filtration rate to kidney weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then polyfructosan (1.25 %) (for 1.5 hours) and 0.9% sodium chloride solution (330 ul/kg/min) (for 1.5 hours) and bovine serum albumin (1 %) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 112 days 9 2.09 ml/min/g 0.42 1.26 ultrasonic flowmeter 0.0 0 104607 2970
LH/Mav glomerular filtration rate to kidney weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 112 days 8 0.99 ml/min/g 0.08 0.23 ultrasonic flowmeter 0.0 0 104609 2970
LH/Mav urine sodium level to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 161 days 10 2.76 mmol/l/100g 0.24 0.76 flame photometry 0.0 0 102057 2645
LH/Mav urine sodium excretion rate to body weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then polyfructosan (1.25 %) (for 1.5 hours) and 0.9% sodium chloride solution (330 ul/kg/min) (for 1.5 hours) and bovine serum albumin (1 %) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. urine sodium amount male 112 days 9 2.49 uEq/min/g 0.25 0.75 urine sodium analysis 0.0 0 104615 2970
LH/Mav body weight controlled hydralazine content drinking water (75 mg/kg/d) (for 63 days) and controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) then controlled sodium chloride content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. body mass male 119 days 6 362.0 g 8.0 19.6 body weighing method 0.0 0 103407 2824
LH/Mav systolic blood pressure control condition (between 147 and 154 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 147 days-154 days 6 2hr mean (10a-12p) continuous mean 175.0 mmHg 1.0 2.45 vascular fluid filled catheter 0.0 0 103436 2825
LH/Mav systolic blood pressure vehicle control condition Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. arterial blood pressure trait male 84 days 8 undefined 160.0 mmHg tail cuff plethysmography 0.0 0 102849 2761
LH/Mav systolic blood pressure hydralazine (75 mg/kg/d) (for 42 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 42 days) and reserpine (0.75 mg/kg/d) (for 42 days) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. arterial blood pressure trait male 63 days 10 undefined 133.0 mmHg 2.0 6.32 tail cuff plethysmography 0.0 0 102852 2761
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. kidney mass male 112 days 14 6.65 g/kg 0.08 0.3 post excision weight measurement 0.0 0 102765 2721
LH/Mav body weight vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. body mass male 49 days-56 days 8 232.0 g 6.0 16.97 body weighing method 0.0 0 102642 2703
LH/Mav timed urine volume vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine output male 49 days-56 days 8 8.7 ml/d 0.6 1.7 urine volume measurement method 0.0 0 102648 2703
LH/Mav urine protein level to urine creatinine level ratio streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. total urine protein amount male 49 days-56 days 37 9.3 null 0.5 3.04 urine protein analysis 0.0 0 102655 2703
LH/Mav blood glucose level streptozotocin (75 mg/kg) then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 37 300.0 mg/dl 8.0 48.66 blood glucose analysis 0.0 0 102661 2703
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 11 10.1 mg/100g 0.2 0.66 post excision weight measurement 0.0 0 102690 2703
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 9 7.02 g/kg 0.18 0.54 post excision weight measurement 0.0 0 102695 2703
LH/Mav urine total protein excretion rate control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. total urine protein amount male 112 days 4 191.0 mg/d 13.0 26.0 urine protein analysis 0.0 0 102811 2723
LH/Mav urine total protein excretion rate control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. total urine protein amount male 161 days 8 260.0 mg/d 27.0 76.37 urine protein analysis 0.0 0 102812 2723
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood creatinine amount male 112 days 14 0.55 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102761 2721
LH/Mav both kidneys wet weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. kidney mass male 112 days 11 6.24 g/kg 0.07 0.23 post excision weight measurement 0.0 0 102764 2721
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. aorta mass male 112 days 14 13.1 mg/100g 0.1 0.37 post excision weight measurement 0.0 0 102773 2721
LH/Mav plasma insulin level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 10 29.17 mU/l 1.42 4.49 radioimmunoassay 0.0 0 102093 2645
LH/Mav body weight vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 56 days 11 246.0 g 4.0 13.27 body weighing method 0.0 0 102700 2721
LH/Mav heart left ventricle weight to body weight ratio perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 8 2.41 mg/g 0.08 0.23 post excision weight measurement 0.0 0 103410 2824
LH/Mav heart left ventricle weight to body weight ratio perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 8 2.37 mg/g 0.07 0.2 post excision weight measurement 0.0 0 103411 2824
LH/Mav both kidneys wet weight to body weight ratio perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 8 5.87 g/kg 0.1 0.28 post excision weight measurement 0.0 0 103421 2824
LH/Mav body weight controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. body mass male 84 days 13 327.0 g 7.0 25.24 body weighing method 0.0 0 103426 2825
LH/Mav body weight controlled losartan content drinking water (10 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. body mass male 147 days-154 days 5 432.0 g 11.0 24.6 body weighing method 0.0 0 103429 2825
LH/Mav systolic blood pressure controlled losartan content drinking water (10 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 84 days 13 between 9a-1p 129.0 mmHg 2.0 7.21 tail cuff plethysmography 0.0 0 103433 2825
LH/Mav systolic blood pressure controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 147 days-154 days 6 2hr mean (10a-12p) continuous mean 167.0 mmHg 2.0 4.9 vascular fluid filled catheter 0.0 0 103438 2825
LH/Mav systolic blood pressure controlled perindopril content drinking water (3 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 147 days-154 days 6 2hr mean (10a-12p) continuous mean 186.0 mmHg 8.0 19.6 vascular fluid filled catheter 0.0 0 103439 2825
LH/Mav blood glucose level streptozotocin (75 mg/kg) then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 14 72.0 mg/dl 1.0 3.74 blood glucose analysis 0.0 0 102717 2721
LH/Mav timed urine volume streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 112 days 14 11.9 ml/d 0.5 1.87 urine volume measurement method 0.0 0 102733 2721
LH/Mav urine creatinine excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine creatinine amount male 112 days 14 13.3 mg/d 0.2 0.75 urine creatinine analysis 0.0 0 102749 2721
LH/Mav creatinine clearance to body weight ratio control condition Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. glomerular filtration trait male 133 days 10 0.45 ml/min/100g 0.01 0.03 automated blood creatinine analysis 0.0 0 . 102029 2645
LH/Mav urine total protein excretion rate to body weight ratio control condition Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. total urine protein amount male 133 days 10 30.59 mg/d/100 g 2.64 8.35 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 102041 2645
LH/Mav body weight streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. body mass male 49 days-56 days 37 233.0 g 4.0 24.33 body weighing method 0.0 0 102643 2703
LH/Mav timed urine volume streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine output male 49 days-56 days 37 12.6 ml/d 0.7 4.26 urine volume measurement method 0.0 0 102649 2703
LH/Mav creatinine clearance to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 7 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. glomerular filtration trait male 161 days 10 0.46 ml/min/100g 0.01 0.03 automated blood creatinine analysis 0.0 0 . 102033 2645
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 10 2.42 mmol/l 0.3 0.95 plasma triglyceride analysis 0.0 0 102671 2703
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 11 0.54 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102678 2703
LH/Mav aorta weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 9 12.3 mg/100g 0.4 1.2 post excision weight measurement 0.0 0 102689 2703
LH/Mav urine sodium level to urine potassium level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 161 days 10 0.52 null 0.03 0.09 flame photometry 0.0 0 102069 2645
LH/Mav plasma renin activity level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. renin activity male 175 days 10 11.62 ng/ml/h 2.24 7.08 plasma renin activity assay 0.0 0 102077 2645
LH/Mav plasma total cholesterol level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood cholesterol amount male 175 days 10 132.82 mg/dl 8.11 25.64 automated plasma total cholesterol analysis 0.0 0 102081 2645
LH/Mav urine sodium excretion rate to body weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. urine sodium amount male 112 days 8 0.79 uEq/min/g 0.18 0.51 urine sodium analysis 0.0 0 104617 2970
LH/Mav renal blood flow rate bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 35 days 9 3.3 ml/min/g 0.2 0.6 ultrasonic flowmeter 0.0 0 104577 2970
LH/Mav urine creatinine excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine creatinine amount male 112 days 11 12.9 mg/d 0.4 1.33 urine creatinine analysis 0.0 0 102748 2721
LH/Mav systolic blood pressure control condition (between 147 and 154 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 84 days 12 between 9a-1p 152.0 mmHg 3.0 10.39 tail cuff plethysmography 0.0 0 103432 2825
LH/Mav urine total protein excretion rate controlled losartan content drinking water (10 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. total urine protein amount male 84 days 13 42.0 mg/d 3.0 10.82 urine protein colorimetric analysis 0.0 0 103445 2825
LH/Mav body weight control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 112 days 8 391.0 g 6.0 16.97 body weighing method 0.0 0 102787 2723
LH/Mav body weight perindopril (0.4 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 112 days 8 405.0 g 7.0 19.8 body weighing method 0.0 0 102790 2723
LH/Mav body weight perindopril (0.01 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 112 days 6 391.0 g 8.0 19.6 body weighing method 0.0 0 102792 2723
LH/Mav timed urine volume vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 56 days 11 8.7 ml/d 0.3 0.99 urine volume measurement method 0.0 0 102708 2721
LH/Mav urine total protein excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 56 days 14 127.0 mg/d 7.0 26.19 urine protein analysis 0.0 0 102713 2721
LH/Mav systolic blood pressure vehicle control condition Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. arterial blood pressure trait male 63 days 8 undefined 160.0 mmHg 3.0 8.49 tail cuff plethysmography 0.0 0 102848 2761
LH/Mav aorta weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. aorta mass male 112 days 11 13.5 mg/100g 0.2 0.66 post excision weight measurement 0.0 0 102772 2721
LH/Mav creatinine clearance streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. glomerular filtration trait male 112 days 14 1.4 ml/min 0.05 0.19 plasma creatinine analysis 0.0 0 102777 2721
LH/Mav timed urine volume vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 112 days 11 11.6 ml/d 0.4 1.33 urine volume measurement method 0.0 0 102732 2721
LH/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood cholesterol amount male 112 days 11 90.35 mg/dl 7.34 24.33 plasma total cholesterol measurement test 0.0 0 102752 2721
LH/Mav body weight streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 56 days 14 248.0 g 4.0 14.97 body weighing method 0.0 0 102701 2721
LH/Mav body weight controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) then controlled sodium chloride content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. body mass male 119 days 8 393.0 g 7.0 19.8 body weighing method 0.0 0 103405 2824
LH/Mav heart left ventricle weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 6 2.88 mg/g 0.06 0.15 post excision weight measurement 0.0 0 103412 2824
LH/Mav aorta weight to body weight ratio controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 7 13.3 mg/100g 0.6 1.59 post excision weight measurement 0.0 0 103414 2824
LH/Mav both kidneys wet weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 6 7.22 g/kg 0.34 0.83 post excision weight measurement 0.0 0 103422 2824
LH/Mav body weight control condition (for 84 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. body mass male 84 days 12 353.0 g 8.0 27.71 body weighing method 0.0 0 103424 2825
LH/Mav systolic blood pressure controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 84 days 13 between 9a-1p 122.0 mmHg 2.0 7.21 tail cuff plethysmography 0.0 0 103434 2825
LH/Mav urine total protein excretion rate controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. total urine protein amount male 84 days 13 41.0 mg/d 2.0 7.21 urine protein colorimetric analysis 0.0 0 103446 2825
LH/Mav urine total protein excretion rate controlled losartan content drinking water (10 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. total urine protein amount male 147 days-154 days 5 159.0 mg/d 20.0 44.72 urine protein colorimetric analysis 0.0 0 103449 2825
LH/Mav body weight control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 161 days 8 442.0 g 8.0 22.63 body weighing method 0.0 0 102801 2723
LH/Mav body weight perindopril (0.4 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 161 days 8 459.0 g 10.0 28.28 body weighing method 0.0 0 102804 2723
LH/Mav body weight perindopril (0.01 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 161 days 6 460.0 g 14.0 34.29 body weighing method 0.0 0 102806 2723
LH/Mav creatinine clearance to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 7 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. glomerular filtration trait male 175 days 10 0.46 ml/min/100g 0.01 0.03 automated blood creatinine analysis 0.0 0 . 102037 2645
LH/Mav blood glucose level streptozotocin (75 mg/kg) then fasting (for 16 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 37 70.0 mg/dl 1.0 6.08 blood glucose analysis 0.0 0 102658 2703
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 8 121.0 mg/dl 6.0 16.97 blood glucose analysis 0.0 0 102660 2703
LH/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 8 66.41 mg/dl 5.41 15.29 blood cholesterol analysis 0.0 0 102663 2703
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 9 82.24 mg/dl 6.95 20.85 blood cholesterol analysis 0.0 0 102664 2703
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 11 1.5 mmol/l 0.12 0.4 plasma triglyceride analysis 0.0 0 102672 2703
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 9 0.54 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102677 2703
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 9 23.8 mg/g 0.8 2.4 post excision weight measurement 0.0 0 102683 2703
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 7 8.05 g/kg 0.24 0.63 post excision weight measurement 0.0 0 102697 2703
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 56 days 11 mean of 3 samples of undefined duration serial mean 134.0 mmHg 4.0 13.27 tail cuff plethysmography 0.0 0 102704 2721
LH/Mav timed urine volume streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 56 days 14 10.6 ml/d 0.3 1.12 urine volume measurement method 0.0 0 102709 2721
LH/Mav urine total protein excretion rate to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 14 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. total urine protein amount male 175 days 10 55.26 mg/d/100 g 3.51 11.1 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 0 102049 2645
LH/Mav plasma triglyceride level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood triglyceride amount male 175 days 10 0.99 mmol/l 0.08 0.25 automated plasma triglyceride analysis 0.0 0 automated plasma triglyceride analysis (MMO:0000734) 102085 2645
LH/Mav mean arterial blood pressure right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 350 days 7 148.0 mmHg 5.0 13.23 vascular fluid filled catheter 0.0 0 104575 2970
LH/Mav glomerular filtration rate to kidney weight ratio right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 350 days 7 0.51 ml/min/g 0.13 0.34 ultrasonic flowmeter 0.0 0 104593 2970
LH/Mav mean arterial blood pressure right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 112 days 8 146.0 mmHg 5.0 14.14 vascular fluid filled catheter 0.0 0 104597 2970
LH/Mav renal blood flow rate right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 112 days 8 8.7 ml/min/g 0.6 1.7 ultrasonic flowmeter 0.0 0 104601 2970
LH/Mav diastolic blood pressure control condition Dubay C, et al., Nat Genet 1993 Apr;3(4):354-7 arterial blood pressure trait male 203 days-217 days 16 serial mean 118.4 mmHg vascular indwelling catheter method abdominal aorta 10800 0 11647 111
LH/Mav mean arterial blood pressure bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 35 days 9 94.0 mmHg 2.0 6.0 vascular fluid filled catheter 0.0 0 104571 2970
LH/Mav renal blood flow rate to kidney weight ratio nifedipine (50 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. renal blood flow trait male 84 days 7 4.9 ml/min/g 0.5 1.32 ultrasonic flowmeter 0.0 0 102855 2761
LH/Mav plasma creatinine level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood creatinine amount male 112 days 11 0.52 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102760 2721
LH/Mav both kidneys wet weight to body weight ratio perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 8 6.22 g/kg 0.21 0.59 post excision weight measurement 0.0 0 103420 2824
LH/Mav urine total protein excretion rate controlled perindopril content drinking water (3 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. total urine protein amount male 147 days-154 days 6 85.0 mg/d 8.0 19.6 urine protein colorimetric analysis 0.0 0 103451 2825
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) then perindopril (0.01 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 10 83.78 mg/dl 6.56 20.76 blood cholesterol analysis 0.0 0 102665 2703
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 7 1.58 mmol/l 0.08 0.21 plasma triglyceride analysis 0.0 0 102673 2703
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 11 19.9 mg/g 0.5 1.66 post excision weight measurement 0.0 0 102684 2703
LH/Mav systolic blood pressure streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. arterial blood pressure trait male 49 days-56 days 37 undefined 145.0 mmHg 2.0 12.17 tail cuff plethysmography 0.0 0 102646 2703
LH/Mav systolic blood pressure control condition Dubay C, et al., Nat Genet 1993 Apr;3(4):354-7 arterial blood pressure trait male 203 days-217 days 16 serial mean 174.1 mmHg vascular indwelling catheter method abdominal aorta 10800 0 11645 111
LH/Mav systolic blood pressure control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. arterial blood pressure trait male 112 days 8 undefined 169.0 mmHg 5.0 14.14 tail cuff plethysmography 0.0 0 102808 2723
LH/Mav systolic blood pressure nifedipine (50 mg/kg/d) (for 42 days) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. arterial blood pressure trait male 63 days 7 undefined 144.0 mmHg 4.0 10.58 tail cuff plethysmography 0.0 0 102851 2761
LH/Mav renal blood flow rate to kidney weight ratio vehicle control condition then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. renal blood flow trait male 84 days 8 5.0 ml/min/g 0.3 0.85 ultrasonic flowmeter 0.0 0 102853 2761
LH/Mav renal blood flow rate to kidney weight ratio perindopril (1.5 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. renal blood flow trait male 84 days 7 5.3 ml/min/g 0.5 1.32 ultrasonic flowmeter 0.0 0 102854 2761
LH/Mav plasma insulin level to plasma glucose level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175 days 10 3.8 mU/mmol 0.25 0.79 radioimmunoassay 0.0 0 mU/mmol plasma insulin level to plasma glucose level ratio (CMO:0003555) 102097 2645
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 112 days 11 mean of 3 samples of undefined duration serial mean 160.0 mmHg 4.0 13.27 tail cuff plethysmography 0.0 0 102728 2721
LH/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 112 days 11 135.0 mg/d 21.0 69.65 urine protein analysis 0.0 0 102736 2721
LH/Mav urine albumin excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 11 24.0 mg/d 4.6 15.26 urine albumin analysis 0.0 0 102740 2721
LH/Mav urine albumin level to urine total protein level ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 11 16.0 % 2.4 7.96 urine albumin analysis 0.0 0 102744 2721
LH/Mav body weight controlled hydralazine content drinking water (75 mg/kg/d) (for 63 days) and controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and controlled reserpine content drinking water (0.75 mg/kg/d) (for 63 days) then controlled sodium chloride content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. body mass male 119 days 7 383.0 g 7.0 18.52 body weighing method 0.0 0 103408 2824
LH/Mav aorta weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 7 15.8 mg/100g 0.8 2.12 post excision weight measurement 0.0 0 103418 2824
LH/Mav body weight control condition (between 147 and 154 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. body mass male 147 days-154 days 6 433.0 g 7.0 17.15 body weighing method 0.0 0 103428 2825
LH/Mav systolic blood pressure controlled perindopril content drinking water (3 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 84 days 12 between 9a-1p 97.0 mmHg 3.0 10.39 tail cuff plethysmography 0.0 0 103435 2825
LH/Mav urine total protein excretion rate controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. total urine protein amount male 147 days-154 days 6 153.0 mg/d 22.0 53.89 urine protein colorimetric analysis 0.0 0 103450 2825
LH/Mav urine sodium excretion rate to body weight ratio control condition (for 84 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. urine sodium amount male 84 days 12 0.0 uEq/min/g 0.0 0.0 flame photometry 0.0 0 103460 2825
LH/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 56 days 11 70.0 mg/d 9.0 29.85 urine protein analysis 0.0 0 102712 2721
LH/Mav body weight perindopril (0.1 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 112 days 8 404.0 g 6.0 16.97 body weighing method 0.0 0 102789 2723
LH/Mav body weight perindopril (0.04 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 112 days 6 372.0 g 9.0 22.05 body weighing method 0.0 0 102793 2723
LH/Mav plasma triglyceride level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 8 1.57 mmol/l 0.06 0.17 plasma triglyceride analysis 0.0 0 102669 2703
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. arterial blood pressure trait male 49 days-56 days 8 undefined 136.0 mmHg 3.0 8.49 tail cuff plethysmography 0.0 0 102645 2703
LH/Mav urine protein level to urine creatinine level ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. total urine protein amount male 49 days-56 days 8 5.9 null 0.5 1.41 urine protein analysis 0.0 0 102654 2703
LH/Mav urine sodium level to urine potassium level ratio control condition Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 133 days 10 0.12 null 0.01 0.03 flame photometry 0.0 0 102065 2645
LH/Mav timed urine volume to body weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then polyfructosan (1.25 %) (for 1.5 hours) and 0.9% sodium chloride solution (330 ul/kg/min) (for 1.5 hours) and bovine serum albumin (1 %) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. urine output male 112 days 9 20.5 ul/min/g 1.9 5.7 urine volume measurement method 0.0 0 104611 2970
LH/Mav timed urine volume to body weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. urine output male 112 days 8 9.3 ul/min/g 1.4 3.96 urine volume measurement method 0.0 0 104613 2970
LH/Mav mean arterial blood pressure right nephrectomy (between 9 and 10 days) then left kidney denervation then polyfructosan (1.25 %) (for 1.5 hours) and 0.9% sodium chloride solution (330 ul/kg/min) (for 1.5 hours) and bovine serum albumin (1 %) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 112 days 9 148.0 mmHg 3.0 9.0 vascular fluid filled catheter 0.0 0 104595 2970
LH/Mav renal vascular resistance to kidney weight ratio vehicle control condition then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. kidney blood vessel physiology trait male 84 days 8 SBP/RBF 33.0 ml/min/g/mmHg 2.0 5.66 ultrasonic flowmeter 0.0 0 102857 2761
LH/Mav renal vascular resistance to kidney weight ratio hydralazine (75 mg/kg/d) (for 63 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. kidney blood vessel physiology trait male 84 days 10 SBP/RBF 27.0 ml/min/g/mmHg 2.0 6.32 ultrasonic flowmeter 0.0 0 102869 2761
LH/Mav body weight controlled perindopril content drinking water (3 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. body mass male 84 days 12 318.0 g 8.0 27.71 body weighing method 0.0 0 103427 2825
LH/Mav diastolic blood pressure control condition (between 147 and 154 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 147 days-154 days 6 2hr mean (10a-12p) continuous mean 116.0 mmHg 4.0 9.8 vascular fluid filled catheter 0.0 0 103440 2825
LH/Mav plasma total cholesterol level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 7 110.81 mg/dl 4.25 11.24 blood cholesterol analysis 0.0 0 102667 2703
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 9 1.96 mmol/l 0.2 0.6 plasma triglyceride analysis 0.0 0 102670 2703
LH/Mav pulse pressure control condition Dubay C, et al., Nat Genet 1993 Apr;3(4):354-7 arterial blood pressure trait male 203 days-217 days 16 serial mean 43.3 mmHg vascular indwelling catheter method abdominal aorta 10800 0 11650 111
LH/Mav renal blood flow rate to kidney weight ratio hydralazine (75 mg/kg/d) (for 63 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. renal blood flow trait male 84 days 10 4.7 ml/min/g 0.3 0.95 ultrasonic flowmeter 0.0 0 102856 2761
LH/Mav renal vascular resistance to kidney weight ratio perindopril (1.5 mg/kg/d) (for 63 days) then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. kidney blood vessel physiology trait male 84 days 7 SBP/RBF 23.0 ml/min/g/mmHg 2.0 5.29 ultrasonic flowmeter 0.0 0 102858 2761
LH/Mav urine sodium excretion rate to body weight ratio controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. urine sodium amount male 84 days 13 0.0 uEq/min/g 0.0 0.0 flame photometry 0.0 0 103462 2825
LH/Mav urine sodium excretion rate to body weight ratio controlled perindopril content drinking water (3 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. urine sodium amount male 84 days 12 0.0 uEq/min/g 0.0 0.0 flame photometry 0.0 0 103463 2825
LH/Mav urine sodium excretion rate to body weight ratio controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. urine sodium amount male 147 days-154 days 6 0.0 uEq/min/g 0.0 0.0 flame photometry 0.0 0 103466 2825
LH/Mav systolic blood pressure control condition (for 0 hours) Cerutti C, et al., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1. arterial blood pressure trait male 84 days 5 161.0 mmHg 6.0 13.42 tail cuff plethysmography 0.0 0 103473 2826
LH/Mav body weight control condition (for 0 hours) Cerutti C, et al., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1. body mass male 84 days 5 360.0 g 6.0 13.42 body weighing method 0.0 0 103479 2826
LH/Mav body weight perindopril (0.1 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 161 days 8 452.0 g 5.0 14.14 body weighing method 0.0 0 102803 2723
LH/Mav body weight control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 161 days 4 431.0 g 8.0 16.0 body weighing method 0.0 0 102805 2723
LH/Mav body weight perindopril (0.04 mg/kg/d) (for 98 days) Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 161 days 6 457.0 g 11.0 26.94 body weighing method 0.0 0 102807 2723
LH/Mav body weight controlled sodium chloride content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. body mass male 119 days 7 407.0 g 9.0 23.81 body weighing method 0.0 0 103404 2824
LH/Mav heart left ventricle weight to body weight ratio controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 7 2.48 mg/g 0.04 0.11 post excision weight measurement 0.0 0 103409 2824
LH/Mav aorta weight to body weight ratio perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 8 12.5 mg/100g 0.6 1.7 post excision weight measurement 0.0 0 103415 2824
LH/Mav aorta weight to body weight ratio perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 8 13.6 mg/100g 0.5 1.41 post excision weight measurement 0.0 0 103416 2824
LH/Mav aorta weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 6 15.7 mg/100g 0.8 1.96 post excision weight measurement 0.0 0 103417 2824
LH/Mav both kidneys wet weight to body weight ratio controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 7 6.81 g/kg 0.19 0.5 post excision weight measurement 0.0 0 103419 2824
LH/Mav both kidneys wet weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 7 7.3 g/kg 0.09 0.24 post excision weight measurement 0.0 0 103423 2824
LH/Mav body weight controlled losartan content drinking water (10 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. body mass male 84 days 13 340.0 g 5.0 18.03 body weighing method 0.0 0 103425 2825
LH/Mav body weight controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. body mass male 147 days-154 days 6 428.0 g 6.0 14.7 body weighing method 0.0 0 103430 2825
LH/Mav body weight controlled perindopril content drinking water (3 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. body mass male 147 days-154 days 6 436.0 g 8.0 19.6 body weighing method 0.0 0 103431 2825
LH/Mav systolic blood pressure controlled losartan content drinking water (10 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 147 days-154 days 5 2hr mean (10a-12p) continuous mean 166.0 mmHg 3.0 6.71 vascular fluid filled catheter 0.0 0 103437 2825
LH/Mav diastolic blood pressure controlled perindopril content drinking water (0.4 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. arterial blood pressure trait male 147 days-154 days 6 2hr mean (10a-12p) continuous mean 110.0 mmHg 3.0 7.35 vascular fluid filled catheter 0.0 0 103442 2825
LH/Mav urine protein excretion rate control condition (for 84 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. total urine protein amount male 84 days 12 85.0 mg/d 7.0 24.25 urine protein colorimetric analysis 0.0 0 103444 2825
LH/Mav urine total protein excretion rate controlled perindopril content drinking water (3 mg/kg/d) (for 63 days) Bertram D, et al., Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1041-5. doi: 10.1152/ajpregu.00620.2001. total urine protein amount male 84 days 12 27.0 mg/d 1.0 3.46 urine protein colorimetric analysis 0.0 0 103447 2825
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 11 69.0 mg/dl 1.0 3.32 blood glucose analysis 0.0 0 102716 2721
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 11 127.0 mg/dl 3.0 9.95 blood glucose analysis 0.0 0 102720 2721
LH/Mav urine total protein excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 112 days 14 184.0 mg/d 11.0 41.16 urine protein analysis 0.0 0 102737 2721
LH/Mav urine albumin excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 14 35.6 mg/d 1.8 6.73 urine albumin analysis 0.0 0 102741 2721
LH/Mav urine albumin level to urine total protein level ratio streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 14 19.6 % 0.7 2.62 urine albumin analysis 0.0 0 102745 2721
LH/Mav body weight control condition Egan EJ, et al., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x. body mass male 112 days 4 374.0 g 6.0 12.0 body weighing method 0.0 0 102791 2723
LH/Mav heart left ventricle weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 8 24.4 mg/g 0.4 1.13 post excision weight measurement 0.0 0 102682 2703
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 8 6.95 g/kg 0.23 0.65 post excision weight measurement 0.0 0 102694 2703
LH/Mav both kidneys wet weight to body weight ratio streptozotocin (75 mg/kg) then perindopril (1 mg/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 11 6.44 g/kg 0.14 0.46 post excision weight measurement 0.0 0 102696 2703
LH/Mav urine creatinine excretion rate vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine creatinine amount male 49 days-56 days 8 8.0 mg/d 0.3 0.85 urine creatinine analysis 0.0 0 102651 2703
LH/Mav urine creatinine excretion rate streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine creatinine amount male 49 days-56 days 37 8.6 mg/d 0.3 1.82 urine creatinine analysis 0.0 0 102652 2703
LH/Mav urine sodium level to urine potassium level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 14 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 175 days 10 0.1 null 0.01 0.03 flame photometry 0.0 0 102073 2645
LH/Mav plasma glucose level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood glucose amount male 175 days 10 140.58 mg/dl 3.96 12.52 automated plasma glucose analysis 0.0 0 automated plasma glucose analysis (MMO:0000735) 102089 2645
LH/Mav renal blood flow rate right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 350 days 7 5.8 ml/min/g 0.3 0.79 ultrasonic flowmeter 0.0 0 104581 2970
LH/Mav urine sodium level to body weight ratio control condition Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 133 days 10 0.49 mmol/l/100g 0.04 0.13 flame photometry 0.0 0 102053 2645
LH/Mav glomerular filtration rate to kidney weight ratio bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta coarctation and celiac artery and superior mesenteric artery coarctation Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 35 days 9 0.99 ml/min/g 0.14 0.42 ultrasonic flowmeter 0.0 0 104589 2970
LH/Mav heart left ventricle weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 7 2.79 mg/g 0.04 0.11 post excision weight measurement 0.0 0 103413 2824
LH/Mav plasma triglyceride level streptozotocin (75 mg/kg) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood triglyceride amount male 112 days 14 2.95 mmol/l 0.27 1.01 plasma triglyceride analysis 0.0 0 102757 2721
LH/Mav heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. heart left ventricle mass male 112 days 11 2.24 mg/g 0.0 0.01 post excision weight measurement 0.0 0 102768 2721
LH/Mav creatinine clearance vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. glomerular filtration trait male 112 days 11 1.6 ml/min 0.1 0.33 plasma creatinine analysis 0.0 0 102776 2721
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 8 67.0 mg/dl 1.0 2.83 blood glucose analysis 0.0 0 102657 2703
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 8 0.61 mg/dl 0.05 0.14 plasma creatinine analysis 0.0 0 102676 2703
LH/Mav plasma creatinine level streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 7 0.59 mg/dl 0.02 0.04 plasma creatinine analysis 0.0 0 102679 2703