Phenominer Database Results (369 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 3BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 150.26 % 4.95 15.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54272 381
FHH-Chr 3BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 143.03 % 5.53 17.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54282 381
FHH-Chr 3BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 43.12 ml/min 3.64 11.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20816 381
FHH-Chr 3BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 169.86 breaths/min 6.49 20.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16976 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 170.83 breaths/min 10.04 31.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18320 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 145.46 breaths/min 7.57 23.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18330 381
FHH-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 375.88 U/l 26.78 75.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36443 401
FHH-Chr 3BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.89 x 1000 cells/ul 0.37 1.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36894 401
FHH-Chr 3BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.11 degrees C 0.06 0.19 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15724 381
FHH-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 1 0.48 mg/dl radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52248 482
FHH-Chr 3BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 118.25 % 9.96 31.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18598 381
FHH-Chr 3BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 144.25 mmol/l 0.37 1.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36515 401
FHH-Chr 3BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.29 mg/dl 0.13 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36803 401
FHH-Chr 3BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 1 236.8 beats/min balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48999 461
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 25.72 ml/min 1.84 5.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20273 381
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 6.4 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49231 461
FHH-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 10.96 % 4.06 10.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49460 461
FHH-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 85.25 U/l 3.63 10.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42824 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.58 g/dl 0.39 1.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39841 401
FHH-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.21 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39728 401
FHH-Chr 3BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42927 401
FHH-Chr 3BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.0 mmol/l 0.21 0.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43352 401
FHH-Chr 3BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 153.99 % 8.82 27.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53697 381
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 49.13 % 1.7 4.8 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59311 526
FHH-Chr 3BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 8.86 mg/dl 0.3 0.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37871 401
FHH-Chr 3BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.64 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41052 401
FHH-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.8 g/kg 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59711 526
FHH-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.67 g/kg 0.09 0.3 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59721 526
FHH-Chr 3BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 39.73 % 0.51 1.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41327 401
FHH-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 19.88 mmol/l 2.38 6.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38325 401
FHH-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 16.63 mmol/l 0.86 2.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38315 401
FHH-Chr 3BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 18.63 mg/dl 1.69 4.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41777 401
FHH-Chr 3BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 21.38 mg/dl 1.58 4.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41796 401
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.59 IU/g 0.09 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47478 461
FHH-Chr 3BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 51.69 fl 0.32 0.9 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38672 401
FHH-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41922 401
FHH-Chr 3BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 188.2 g 3.5 10.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55214 522
FHH-Chr 3BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.3 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16538 381
FHH-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 0.79 E-7mole 0.11 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55929 522
FHH-Chr 3BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54709 522
FHH-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.09 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59932 526
FHH-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 7 74.0 % 5.72 15.13 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57240 522
FHH-Chr 3BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 25.0 mmHg 1.62 4.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48097 461
FHH-Chr 3BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 95.62 % 6.96 18.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48470 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 150.46 beats/min 36.22 81.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45201 461
FHH-Chr 3BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 212.77 beats/min 13.21 34.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49009 461
FHH-Chr 3BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 159.61 breaths/min 3.18 10.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17166 381
FHH-Chr 3BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 4 383.08 mg/d 142.25 284.5 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52117 482
FHH-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 8.95 mg/dl 0.12 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36678 401
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 0.64 IU/g 0.07 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47342 461
FHH-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 post-ischemic value/pre-ischemic value x 100% 55.42 % balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46373 461
FHH-Chr 3BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.28 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17435 381
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 35.57 mmHg 6.48 14.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45323 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.47 ml/min/g 0.81 2.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46716 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 75.24 mmHg 6.84 18.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46814 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 82.61 mmHg 5.94 15.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44879 461
FHH-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 44.19 ml/min/kg 4.95 14.0 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58063 526
FHH-Chr 3BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -6.49 null 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56950 522
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 80.74 mmHg 6.7 17.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45568 461
FHH-Chr 3BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 13.55 g/dl 0.18 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40127 401
FHH-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 1206.6 s 46.52 104.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50280 461
FHH-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.25 g/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42287 401
FHH-Chr 3BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 107.25 U/l 3.37 9.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42461 401
FHH-Chr 3BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.18 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15462 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.22 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13978 381
FHH-Chr 3BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.41 x 1000 cells/ul 0.55 1.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36913 401
FHH-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 65.88 mg/dl 2.87 8.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37151 401
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.2 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15288 381
FHH-Chr 3BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 111.79 breaths/min 4.22 13.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15000 381
FHH-Chr 3BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 2 438.8 beats/min 13.17 18.62 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52489 482
FHH-Chr 3BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 3 1.07 mEq/d 0.58 1.01 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52315 482
FHH-Chr 3BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 3 0.68 ml/min 0.25 0.44 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52362 482
FHH-Chr 3BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.16 degrees C 0.12 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13624 381
FHH-Chr 3BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 229.1 % 17.89 56.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14253 381
FHH-Chr 3BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 112.65 % 7.67 24.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18608 381
FHH-Chr 3BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.01 mg/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36784 401
FHH-Chr 3BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 268.63 U/l 20.75 58.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37475 401
FHH-Chr 3BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 144.38 mmol/l 0.65 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36534 401
FHH-Chr 3BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.93 degrees C 0.11 0.33 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19124 381
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 37.1 ml/min 3.15 9.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18717 381
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 5.49 mmHg 0.21 0.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49241 461
FHH-Chr 3BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.16 degrees C 0.12 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19134 381
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 94.14 mmHg 14.37 32.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49941 461
FHH-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 5 29.6 mmHg 6.54 14.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50050 461
FHH-Chr 3BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 95.88 U/l 2.83 8.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42442 401
FHH-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.18 g/dl 0.12 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42297 401
FHH-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 55.73 fl 0.65 1.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38809 401
FHH-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.88 mmol/l 1.03 2.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39452 401
FHH-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 109.0 mmol/l 1.34 3.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39181 401
FHH-Chr 3BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 152.53 % 11.03 34.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54478 381
FHH-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.18 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39738 401
FHH-Chr 3BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.38 mmol/l 0.24 0.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43371 401
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.71 mg/kg 0.41 1.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58960 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.32 mg/kg 0.82 2.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58970 526
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.93 pg 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40242 401
FHH-Chr 3BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 105.63 mmol/l 0.63 1.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40031 401
FHH-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 6 9.07 mg/dl 0.3 0.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37658 401
FHH-Chr 3BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 129.0 mg/dl 2.85 8.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41219 401
FHH-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59611 526
FHH-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.63 mmol/l 0.26 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38130 401
FHH-Chr 3BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 1 969.0 s balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46602 461
FHH-Chr 3BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 49.74 fl 0.22 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38691 401
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 23.19 ml/min/kg 2.37 6.71 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57864 526
FHH-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.96 degrees C 0.1 0.33 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16627 381
FHH-Chr 3BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 49.27 ml/min/kg 1.24 3.5 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58270 526
FHH-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 9 0.6 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58787 526
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 15.67 ml/min/kg 2.22 5.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60019 526
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 11.19 ml/min/kg 0.81 2.3 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60038 526
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 10.85 IU/g 1.15 2.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45977 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 14.02 IU/g 2.17 6.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45991 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 52.19 mmHg 2.98 7.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47765 461
FHH-Chr 3BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 7 62.3 g 2.5 6.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47829 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 30.42 mmHg 4.83 12.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47975 461
FHH-Chr 3BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 231.37 beats/min 13.15 37.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48261 461
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 110.72 % 7.4 23.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53948 381
FHH-Chr 3BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.0 degrees C 0.07 0.24 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15734 381
FHH-Chr 3BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 10 189.2 g 4.5 14.3 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17882 381
FHH-Chr 3BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 116.38 breaths/min 4.54 14.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18475 381
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 34.15 g/dl 0.12 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37353 401
FHH-Chr 3BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 1 10.05 mEq/d flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52785 482
FHH-Chr 3BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 4 369.39 beats/min 27.99 55.99 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52507 482
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 149.85 beats/min 16.91 41.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45211 461
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 76.71 % 8.44 22.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46129 461
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 77.0 g 11.3 33.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49534 461
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 89.1 g 6.4 19.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49553 461
FHH-Chr 3BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54690 522
FHH-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58553 526
FHH-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 56.83 fl 0.37 1.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38799 401
FHH-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1324.5 s 67.5 190.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50290 461
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 9 125.6 g 3.5 10.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59116 526
FHH-Chr 3BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 19.88 ml/min 2.08 6.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16212 381
FHH-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 18.88 mmol/l 1.48 4.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42126 401
FHH-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 4.09 E-7mole 1.01 3.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56555 522
FHH-Chr 3BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 9 133.2 g 6.4 19.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55430 522
FHH-Chr 3BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 107.14 breaths/min 3.72 11.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14990 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 120.68 breaths/min 4.64 14.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14859 381
FHH-Chr 3BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 225.77 % 7.29 23.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14263 381
FHH-Chr 3BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.04 degrees C 0.1 0.31 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13614 381
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 104.34 % 3.74 11.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53816 381
FHH-Chr 3BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.79 breaths/min 4.27 13.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18465 381
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 32.04 ml/min 3.04 9.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18727 381
FHH-Chr 3BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 173.56 breaths/min 10.07 31.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16966 381
FHH-Chr 3BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 49.33 ml/min 3.21 10.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14565 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.21 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15298 381
FHH-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 4 125.32 mg/d 56.48 112.96 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52409 482
FHH-Chr 3BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 2 259.8 mg/d 89.85 127.07 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52099 482
FHH-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 174.34 % 13.15 41.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13735 381
FHH-Chr 3BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 158.35 breaths/min 4.05 12.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17176 381
FHH-Chr 3BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 10 151.1 g 2.8 8.7 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17872 381
FHH-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.5 mg/dl 0.38 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36688 401
FHH-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 5 964.8 s 44.0 98.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49352 461
FHH-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.2 x 10E6 cells/ul 0.2 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39301 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.16 pg 0.05 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42609 401
FHH-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.31 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39630 401
FHH-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.31 mg/dl 0.04 0.11 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39640 401
FHH-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.58 x 1000 cells/ul 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43288 401
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 3.42 mg/kg 0.81 2.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59208 526
FHH-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.71 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40614 401
FHH-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.05 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59402 526
FHH-Chr 3BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.17 g/kg 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59479 526
FHH-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 6 145.17 mg/dl 4.77 11.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38594 401
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 97.39 mmHg 13.03 29.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48677 461
FHH-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 -7.95 null 0.15 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55310 522
FHH-Chr 3BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.58 g/mg 0.16 0.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57350 522
FHH-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 90.74 % 5.43 12.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48809 461
FHH-Chr 3BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 18.87 ml/min 0.97 3.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16202 381
FHH-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 49.58 ml/min/kg 4.09 12.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58053 526
FHH-Chr 3BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 171.9 g 8.5 26.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58382 526
FHH-Chr 3BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 1.76 g/mg 0.09 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55823 522
FHH-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.54 null 0.05 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58177 526
FHH-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58543 526
FHH-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -8.16 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56121 522
FHH-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 57.4 % 6.81 21.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54815 522
FHH-Chr 3BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54922 522
FHH-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.83 E-7mole 0.28 0.89 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56536 522
FHH-Chr 3BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 8 5.15 g/kg 0.58 1.65 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47026 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 102.7 mmHg 13.12 29.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45782 461
FHH-Chr 3BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.19 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18037 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.22 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13988 381
FHH-Chr 3BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 1 236.8 beats/min balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48251 461
FHH-Chr 3BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 1 36.0 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48087 461
FHH-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 7.76 g/kg 0.49 1.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45651 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 91.4 mmHg 10.39 29.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45792 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 4.43 ml/min/g 0.67 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44771 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 5.11 ml/min/g 1.21 3.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44781 461
FHH-Chr 3BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.28 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16528 381
FHH-Chr 3BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 7 -7.02 null 0.1 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55641 522
FHH-Chr 3BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -7.14 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55660 522
FHH-Chr 3BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 1.58 g/mg 0.19 0.58 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55804 522
FHH-Chr 3BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 4.33 x 1000 cells/ul 0.42 1.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39910 401
FHH-Chr 3BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 24.63 mmol/l 0.98 2.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43034 401
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 126.53 % 7.54 23.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54389 381
FHH-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 6 0.67 g 0.07 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45458 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 63.6 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45558 461
FHH-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.55 x 1000 cells/ul 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43278 401
FHH-Chr 3BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.13 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40319 401
FHH-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 37.34 % 4.74 10.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48580 461
FHH-Chr 3BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 40.94 % 1.33 3.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41346 401
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 23.72 ml/min/kg 1.41 4.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57854 526
FHH-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 9 0.25 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57926 526
FHH-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.26 null 0.01 0.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57945 526
FHH-Chr 3BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 4 184.08 mmHg 15.31 30.63 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52554 482
FHH-Chr 3BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 4 7.48 mEq/d 3.66 7.33 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52803 482
FHH-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 3 0.83 mg/dl 0.28 0.48 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52266 482
FHH-Chr 3BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 1 0.53 mEq/d flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52297 482
FHH-Chr 3BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 1 0.7 ml/min urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52344 482
FHH-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 139.2 % 11.85 37.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13745 381
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 108.37 % 6.65 21.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53806 381
FHH-Chr 3BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.2 g/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37223 401
FHH-Chr 3BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.18 ml 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15452 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 107.61 % 5.07 16.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54049 381
FHH-Chr 3BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.2 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18047 381
FHH-Chr 3BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.14 g/dl 0.17 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37242 401
FHH-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 5 6.72 % 3.09 6.91 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49751 461
FHH-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 9.16 % 1.79 4.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49761 461
FHH-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 1 3.71 % digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49450 461
FHH-Chr 3BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.28 x 1000 cells/ul 0.05 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38921 401
FHH-Chr 3BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.48 x 1000 cells/ul 0.09 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38940 401
FHH-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 20.0 mmol/l 1.07 3.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42116 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.5 pg 0.07 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42599 401
FHH-Chr 3BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 159.1 % 5.81 18.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54488 381
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.59 g/dl 0.25 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39831 401
FHH-Chr 3BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 17.88 mmol/l 0.35 0.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43156 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.65 pg 0.07 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40223 401
FHH-Chr 3BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 13.93 g/dl 0.41 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40146 401
FHH-Chr 3BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.46 g/dl 0.09 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40451 401
FHH-Chr 3BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 162.01 % 8.7 27.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53687 381
FHH-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 61.38 U/l 7.26 20.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40778 401
FHH-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.03 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59383 526
FHH-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.65 g/dl 0.06 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40604 401
FHH-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 10.07 mg/dl 0.45 1.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37648 401
FHH-Chr 3BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 46.38 U/l 3.7 10.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37732 401
FHH-Chr 3BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 8.73 mg/dl 0.28 0.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37852 401
FHH-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.25 mmol/l 0.13 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38120 401
FHH-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.86 x 1000 cells/ul 0.49 1.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41567 401
FHH-Chr 3BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.03 x 1000 cells/ul 0.02 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41429 401
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 85.95 mmHg 10.2 28.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48687 461
FHH-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41932 401
FHH-Chr 3BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 7.69 x 10E6 cells/ul 0.12 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41994 401
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 13.05 ml/min/kg 1.84 5.19 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57662 526
FHH-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 84.0 % 3.53 11.16 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57259 522
FHH-Chr 3BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 39.73 % 0.51 1.43 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57512 526
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 1 6.31 IU/g isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48872 461
FHH-Chr 3BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 40.94 % 1.33 3.75 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57531 526
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 14.86 ml/min/kg 0.81 2.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57652 526
FHH-Chr 3BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 167.1 g 10.0 31.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55449 522
FHH-Chr 3BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 9 143.3 g 5.7 17.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58363 526
FHH-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.49 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58167 526
FHH-Chr 3BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.01 degrees C 0.11 0.34 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16877 381
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 28.97 ml/min/kg 2.29 5.61 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58648 526
FHH-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.08 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59913 526
FHH-Chr 3BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -6.78 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56931 522
FHH-Chr 3BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.27 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17425 381
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.45 mmHg 0.38 1.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47260 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 31.7 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47965 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 35.94 mmHg 6.71 16.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45333 461
FHH-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.15 degrees C 0.04 0.14 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20364 381
FHH-Chr 3BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 170.17 % 10.25 32.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54148 381
FHH-Chr 3BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 44.27 ml/min 3.91 12.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20826 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 119.67 % 8.12 25.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53938 381
FHH-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 68.63 mg/dl 2.95 8.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37161 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 34.08 g/dl 0.13 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37372 401
FHH-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 2 100.4 mg/d 43.43 61.41 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52391 482
FHH-Chr 3BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 262.93 % 21.04 66.53 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19266 381
FHH-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 103.7 % 5.47 14.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44982 461
FHH-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 71.02 % 17.68 39.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48348 461
FHH-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 6 7.58 g/kg 1.12 2.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45632 461
FHH-Chr 3BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 1 post-ischemic value/pre-ischemic value x 100% 100.0 % balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48460 461
FHH-Chr 3BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 68.8 g 2.6 8.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47848 461
FHH-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 post-ischemic value/pre-ischemic value x 100% 135.22 % balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44972 461
FHH-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 95.75 U/l 9.61 27.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42834 401
FHH-Chr 3BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.81 degrees C 0.09 0.3 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16867 381
FHH-Chr 3BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 21.57 ml/min 1.35 4.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16745 381
FHH-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 1025.38 s 46.26 130.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49362 461
FHH-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 142.63 mg/dl 7.14 20.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38584 401
FHH-Chr 3BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 24.75 mmol/l 0.31 0.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43015 401
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 58.58 mmHg 9.9 22.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46470 461
FHH-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.56 null 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58797 526
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 49.13 % 1.7 4.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39045 401
FHH-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 22.88 mg/dl 1.61 4.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40882 401
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 17.84 IU/g 3.57 9.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48889 461
FHH-Chr 3BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.68 g/dl 0.08 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41071 401
FHH-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59601 526
FHH-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.71 g/dl 0.39 1.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38032 401
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 125.33 breaths/min 6.75 21.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14849 381
FHH-Chr 3BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 2 198.41 mmHg 7.67 10.85 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52536 482
FHH-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 1 1.17 ng/ml/h radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52883 482
FHH-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 3 1.53 ng/ml/h 1.17 2.02 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52901 482
FHH-Chr 3BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 49.07 ml/min 4.34 13.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14555 381
FHH-Chr 3BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 161.82 % 11.62 36.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54138 381
FHH-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 289.75 U/l 15.64 44.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36433 401
FHH-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.9 g/dl 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37016 401
FHH-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.89 g/dl 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37026 401
FHH-Chr 3BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 5 0.35 g 0.03 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49114 461
FHH-Chr 3BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 8 0.36 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49124 461
FHH-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.1 degrees C 0.03 0.11 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20374 381
FHH-Chr 3BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 258.45 % 15.07 47.66 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19276 381
FHH-Chr 3BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 1 581.0 s balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50173 461
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 51.36 % 1.44 4.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39055 401
FHH-Chr 3BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.2 mg/dl 0.0 0.0 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42671 401
FHH-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 109.63 mmol/l 0.71 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39171 401
FHH-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.64 x 10E6 cells/ul 0.28 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39291 401
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 147.75 % 10.04 31.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54379 381
FHH-Chr 3BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 19.0 mmol/l 0.6 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43175 401
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 138.3 g 8.8 27.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59126 526
FHH-Chr 3BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 105.0 mmol/l 0.27 0.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40050 401
FHH-Chr 3BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.56 g/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40432 401
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 51.36 % 1.44 4.07 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59321 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 1.95 mg/kg 0.52 1.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59189 526
FHH-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 6.5 x 1000 cells/ul 0.54 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40980 401
FHH-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 25.13 mg/dl 2.76 7.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40892 401
FHH-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 53.13 U/l 3.5 9.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40768 401
FHH-Chr 3BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 0.99 g/kg 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59498 526
FHH-Chr 3BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 70.63 U/l 4.24 11.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37751 401
FHH-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.0 g/dl 0.51 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38022 401
FHH-Chr 3BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 142.88 mg/dl 5.7 16.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41238 401
FHH-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.04 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41711 401
FHH-Chr 3BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 81.0 mg/dl 1.55 4.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38458 401
FHH-Chr 3BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 89.13 mg/dl 3.49 9.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38477 401
FHH-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.44 null 0.08 0.19 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59797 526
FHH-Chr 3BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.23 x 10E6 cells/ul 0.25 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42013 401
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 37.89 mmHg 3.82 9.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46480 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 221.87 beats/min 11.62 25.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47635 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 204.56 beats/min 15.67 44.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47645 461
FHH-Chr 3BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 1161.0 s 68.59 181.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46612 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 0.51 IU/g 0.21 0.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47461 461
FHH-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.69 g 0.06 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45468 461
FHH-Chr 3BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 1.42 g/mg 0.21 0.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57369 522
FHH-Chr 3BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 141.6 g 3.5 10.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55196 522
FHH-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.98 null 0.08 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55291 522
FHH-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.11 degrees C 0.1 0.33 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16637 381
FHH-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 7 1.14 E-7mole 0.31 0.81 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55910 522
FHH-Chr 3BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 23.05 ml/min 1.28 4.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16755 381
FHH-Chr 3BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 72.96 ml/min/kg 8.89 21.78 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58251 526
FHH-Chr 3BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54941 522
FHH-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -8.28 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56140 522
FHH-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 63.6 % 4.17 13.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54796 522
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 19.25 ml/min/kg 1.26 3.57 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58667 526
FHH-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.39 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59816 526
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 10.35 ml/min/g 1.58 3.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46933 461
FHH-Chr 3BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 5 5.47 g/kg 0.59 1.31 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47007 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 57.2 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 46804 461
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 46.79 % 6.82 15.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47130 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 1 3.9 ml/min/g isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46255 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 7.37 ml/min/g 1.21 2.97 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46265 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 86.0 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44869 461
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 24.95 ml/min 2.27 7.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20263 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 108.96 % 5.76 18.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54039 381
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 49.25 % 8.18 21.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47140 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 5.31 mmHg 0.4 0.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47250 461
FHH-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 80.33 % 11.87 29.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48358 461
FHH-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 40.2 % 4.83 12.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46383 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 9.52 ml/min/g 0.57 1.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46706 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 54.3 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47755 461
FHH-Chr 3BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42690 401
FHH-Chr 3BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.05 x 1000 cells/ul 0.03 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41448 401
FHH-Chr 3BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42908 401
FHH-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.64 x 1000 cells/ul 0.48 1.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41557 401
FHH-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.1 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41701 401
FHH-Chr 3BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 5.09 x 1000 cells/ul 0.63 1.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39929 401
FHH-Chr 3BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.16 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40338 401
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 73.83 mmHg 7.92 19.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49951 461
FHH-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 17.88 mmHg 2.75 7.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50060 461
FHH-Chr 3BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 928.29 s 52.95 140.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50183 461
FHH-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 87.4 % 20.48 50.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48819 461
FHH-Chr 3BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 368.0 U/l 22.83 64.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37494 401
FHH-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 44.17 % 12.84 31.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48590 461
FHH-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 5.66 x 1000 cells/ul 0.47 1.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40990 401
FHH-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 141.88 mmol/l 0.4 1.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39442 401