Phenominer Database Results (463 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 1BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 -0.07 degrees C 0.38 1.08 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16007 381
FHH-Chr 1BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 158.35 breaths/min 5.58 21.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17126 381
FHH-Chr 1BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 108.51 % 3.5 14.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53912 381
FHH-Chr 1BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 106.0 % 4.38 17.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54013 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 118.6 mmHg 6.44 18.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20052 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -6.02 mmHg 1.38 3.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20086 381
FHH-Chr 1BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 105.19 breaths/min 4.26 18.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18425 381
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 114.15 mmHg 3.97 10.52 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18916 381
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 30.64 mmHg 1.37 4.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 14483 381
FHH-Chr 1BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 86.28 ml/min 3.79 14.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14515 381
FHH-Chr 1BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.45 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14602 381
FHH-Chr 1BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 -0.69 degrees C 0.36 1.4 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15684 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 113.99 mmHg 3.85 10.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15141 381
FHH-Chr 1BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 445.83 beats/min 7.54 22.62 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52513 482
FHH-Chr 1BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 10 0.94 mEq/d 0.09 0.27 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52338 482
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 25.93 mmHg 1.05 3.47 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13446 381
FHH-Chr 1BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 403.98 beats/min 13.88 39.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17744 381
FHH-Chr 1BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 12 439.05 beats/min 5.79 20.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17758 381
FHH-Chr 1BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 22 224.4 g 5.5 25.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17832 381
FHH-Chr 1BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 18 -0.34 degrees C 0.19 0.82 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20324 381
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 94.47 mmHg 5.26 15.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49903 461
FHH-Chr 1BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 9.2 % 4.39 13.88 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49724 461
FHH-Chr 1BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 12 1.12 x 1000 cells/ul 0.15 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38948 401
FHH-Chr 1BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 13 58.02 fl 0.58 2.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38760 401
FHH-Chr 1BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 15 3.89 g/dl 0.05 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42248 401
FHH-Chr 1BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 14 8.26 x 10E6 cells/ul 0.09 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42046 401
FHH-Chr 1BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 127.3 % 7.08 28.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54353 381
FHH-Chr 1BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 18 4.44 mmol/l 0.09 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43379 401
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.96 mg/kg 1.01 3.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58932 526
FHH-Chr 1BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 163.65 % 8.9 34.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53652 381
FHH-Chr 1BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 18 3.88 g/dl 0.04 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40484 401
FHH-Chr 1BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 18 0.9 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59506 526
FHH-Chr 1BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 18 84.83 U/l 6.37 27.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37759 401
FHH-Chr 1BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 23.67 mmol/l 0.71 2.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38287 401
FHH-Chr 1BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 18 73.83 mg/dl 1.31 5.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38510 401
FHH-Chr 1BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 18 15.33 mg/dl 0.68 2.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41804 401
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 125.16 mmHg 4.18 12.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45519 461
FHH-Chr 1BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1143.03 s 39.64 118.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46574 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 143.14 mmHg 6.57 20.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48639 461
FHH-Chr 1BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 15 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41883 401
FHH-Chr 1BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41894 401
FHH-Chr 1BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.56 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55318 522
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 15.64 ml/min/kg 1.23 4.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57613 526
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 11.24 mmHg 3.48 9.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16289 381
FHH-Chr 1BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 26 1.43 g/mg 0.07 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57376 522
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 106.11 mmHg 3.28 9.83 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16417 381
FHH-Chr 1BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 215.6 g 5.0 15.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55457 522
FHH-Chr 1BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 52.21 ml/min/kg 5.22 18.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58014 526
FHH-Chr 1BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 18 37.81 degrees C 0.16 0.68 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16827 381
FHH-Chr 1BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 26 -7.27 null 0.14 0.73 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56171 522
FHH-Chr 1BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 26 0.17 umol/l 0.04 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54972 522
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 13.07 % 3.87 14.47 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55097 522
FHH-Chr 1BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59965 526
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 50.67 % 3.64 10.92 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57182 522
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.18 mmHg 0.28 0.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47212 461
FHH-Chr 1BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 260.6 beats/min 21.86 69.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45163 461
FHH-Chr 1BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 97.25 % 4.99 14.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44944 461
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.33 IU/g 0.1 0.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47373 461
FHH-Chr 1BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 81.32 % 3.3 9.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48432 461
FHH-Chr 1BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.78 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49075 461
FHH-Chr 1BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 181.14 % 5.27 19.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54112 381
FHH-Chr 1BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 476.99 beats/min 8.09 22.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20970 381
FHH-Chr 1BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.28 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15423 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 120.39 mmHg 5.08 14.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13512 381
FHH-Chr 1BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during7-9 min hypercapnia/control during standard conditions 276.47 % 13.87 53.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14213 381
FHH-Chr 1BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 171.41 breaths/min 6.56 25.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16926 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 135.91 mmHg 6.19 17.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18945 381
FHH-Chr 1BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 495.06 beats/min 14.24 40.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13801 381
FHH-Chr 1BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 113.79 breaths/min 5.38 21.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14820 381
FHH-Chr 1BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 14 37.21 degrees C 0.24 0.89 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19095 381
FHH-Chr 1BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 %change=VE during 2-3 min hypercapnia/control during standard conditions 272.29 % 10.49 39.25 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19237 381
FHH-Chr 1BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 93.4 % 3.73 11.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48321 461
FHH-Chr 1BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 15.29 ml/min/g 0.72 2.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46679 461
FHH-Chr 1BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.12 g/kg 0.25 0.78 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45684 461
FHH-Chr 1BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 173.6 g 10.5 33.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47856 461
FHH-Chr 1BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 71.44 % 10.82 32.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44933 461
FHH-Chr 1BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.51 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16499 381
FHH-Chr 1BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 -6.9 null 0.07 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55668 522
FHH-Chr 1BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 14 5.3 x 1000 cells/ul 0.51 1.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39962 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 32.01 g/dl 0.12 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39803 401
FHH-Chr 1BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.03 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54742 522
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.34 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47486 461
FHH-Chr 1BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 163.7 g 3.9 12.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59088 526
FHH-Chr 1BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 24 0.19 umol/l 0.05 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54948 522
FHH-Chr 1BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 16 0.31 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58748 526
FHH-Chr 1BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 15 89.13 U/l 10.4 40.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40729 401
FHH-Chr 1BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 28 1.96 g/mg 0.16 0.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57400 522
FHH-Chr 1BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 18 380.28 U/l 22.96 97.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37502 401
FHH-Chr 1BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 18 255.28 U/l 13.46 57.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37527 401
FHH-Chr 1BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 15 8.84 mg/dl 0.38 1.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37609 401
FHH-Chr 1BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 8.26 mg/dl 0.26 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37620 401
FHH-Chr 1BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 55.3 % 0.61 1.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39017 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 18.86 pg 0.32 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42560 401
FHH-Chr 1BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59573 526
FHH-Chr 1BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 0.14 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59562 526
FHH-Chr 1BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 173.7 g 5.5 17.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55482 522
FHH-Chr 1BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 116.89 breaths/min 7.15 26.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14961 381
FHH-Chr 1BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 10 11.87 mEq/d 2.05 6.48 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52826 482
FHH-Chr 1BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 3.1 ng/ml/h 0.58 1.53 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52907 482
FHH-Chr 1BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 1.27 mEq/d 0.08 0.25 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52321 482
FHH-Chr 1BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 10 9.79 mg/d 2.7 8.53 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52432 482
FHH-Chr 1BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 0.37 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13938 381
FHH-Chr 1BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 12 499.19 beats/min 11.73 40.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13815 381
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 27.65 mmHg 0.67 2.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17268 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 116.98 mmHg 6.2 16.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14379 381
FHH-Chr 1BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 87.04 ml/min 4.07 15.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14526 381
FHH-Chr 1BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 7.46 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14616 381
FHH-Chr 1BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 0.32 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15259 381
FHH-Chr 1BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 151.06 % 6.84 26.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54237 381
FHH-Chr 1BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 36.61 degrees C 0.29 1.11 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13574 381
FHH-Chr 1BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 12 heart rate during walking-heart rate during rest 60.15 beats/min 13.17 45.61 vascular fluid filled catheter 0 0 Moms and pups used in studies were fed Teklad 13412 381
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 26.46 mmHg 1.05 2.97 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13432 381
FHH-Chr 1BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 122.48 % 6.61 28.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53771 381
FHH-Chr 1BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 115.65 % 4.49 19.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53903 381
FHH-Chr 1BN/Mcwi absolute change in blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19831 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 116.27 mmHg 6.93 19.61 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19893 381
FHH-Chr 1BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 0.32 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17997 381
FHH-Chr 1BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 0.31 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18008 381
FHH-Chr 1BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.23 degrees C 0.33 1.15 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17660 381
FHH-Chr 1BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.44 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20670 381
FHH-Chr 1BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 15 390.33 U/l 17.97 69.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36394 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 14 31.95 g/dl 0.1 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37405 401
FHH-Chr 1BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 18 5.67 g/dl 0.05 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37250 401
FHH-Chr 1BN/Mcwi heart rate air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 467.14 beats/min 24.71 65.38 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17552 381
FHH-Chr 1BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.58 degrees C 0.13 0.46 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18144 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 -52.62 mmHg 2.5 7.49 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19491 381
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 55.07 mmHg 1.17 3.89 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20503 381
FHH-Chr 1BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 4.73 % 2.0 6.34 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49411 461
FHH-Chr 1BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 111.56 mmol/l 0.71 2.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39143 401
FHH-Chr 1BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 15 14.93 mmol/l 0.48 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42077 401
FHH-Chr 1BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 18 22.17 mmol/l 0.47 1.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43067 401
FHH-Chr 1BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.26 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39700 401
FHH-Chr 1BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 18 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42935 401
FHH-Chr 1BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 16 178.9 g 3.3 13.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59077 526
FHH-Chr 1BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 151.9 % 7.66 28.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53661 381
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 17 2.89 mg/kg 0.49 2.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59216 526
FHH-Chr 1BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 18.48 g/dl 0.33 1.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37983 401
FHH-Chr 1BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 17.71 g/dl 0.23 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37994 401
FHH-Chr 1BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 16 1.52 g/kg 0.07 0.26 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59672 526
FHH-Chr 1BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 18 141.39 mg/dl 3.76 15.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41246 401
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.39 IU/g 0.08 0.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47511 461
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 54.65 mmHg 3.65 10.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46432 461
FHH-Chr 1BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 68.29 % 3.41 10.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48782 461
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 33.44 mmHg 0.81 2.14 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16116 381
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 13.84 ml/min/kg 0.9 2.84 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57624 526
FHH-Chr 1BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 50.5 ml/min/kg 3.82 12.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58025 526
FHH-Chr 1BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.32 g/mg 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55856 522
FHH-Chr 1BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 1.36 E-7mole 0.21 0.56 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55937 522
FHH-Chr 1BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 0.04 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55749 522
FHH-Chr 1BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 99.33 % 0.35 1.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56319 522
FHH-Chr 1BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 19 -8.75 null 0.14 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56042 522
FHH-Chr 1BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 13 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58504 526
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 15.15 ml/min/kg 2.02 8.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58675 526
FHH-Chr 1BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 99.56 % 0.34 1.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56479 522
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 48.06 % 6.51 26.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57150 522
FHH-Chr 1BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 110.75 mmHg 4.97 14.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46776 461
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 99.51 mmHg 6.66 19.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44830 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 59.33 mmHg 8.69 26.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47926 461
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.21 IU/g 0.04 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47350 461
FHH-Chr 1BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 45.23 % 9.67 29.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46334 461
FHH-Chr 1BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 36.64 ml/min 2.19 8.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20234 381
FHH-Chr 1BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.27 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15412 381
FHH-Chr 1BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 -0.07 degrees C 0.21 0.78 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15695 381
FHH-Chr 1BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 -0.01 null 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14777 381
FHH-Chr 1BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 14 4.39 x 1000 cells/ul 0.55 2.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36946 401
FHH-Chr 1BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 10 189.0 mg/d 36.58 115.68 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52123 482
FHH-Chr 1BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 98.7 % 10.16 32.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48421 461
FHH-Chr 1BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.43 ml/min/g 0.25 0.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44744 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.92 ml/min/g 1.26 3.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46896 461
FHH-Chr 1BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 41.1 mmHg 1.92 6.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48048 461
FHH-Chr 1BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -6.94 null 0.11 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55693 522
FHH-Chr 1BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 33.67 ml/min 1.66 7.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16705 381
FHH-Chr 1BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.31 null 0.02 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58139 526
FHH-Chr 1BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.24 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39602 401
FHH-Chr 1BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 13 3.83 x 1000 cells/ul 0.41 1.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41518 401
FHH-Chr 1BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 3.22 x 1000 cells/ul 0.38 1.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41529 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 32.48 g/dl 0.27 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39792 401
FHH-Chr 1BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 13 0.99 x 1000 cells/ul 0.12 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43239 401
FHH-Chr 1BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41673 401
FHH-Chr 1BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 24 -7.21 null 0.15 0.76 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56147 522
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 50.14 mmHg 2.18 6.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46443 461
FHH-Chr 1BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.85 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45431 461
FHH-Chr 1BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1154.0 s 24.51 77.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50253 461
FHH-Chr 1BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 32.47 ml/min 1.7 6.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16173 381
FHH-Chr 1BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 18 1.72 g/dl 0.05 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41079 401
FHH-Chr 1BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 13 9.8 x 10E6 cells/ul 0.08 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39252 401
FHH-Chr 1BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 145.33 mmol/l 0.44 1.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39414 401
FHH-Chr 1BN/Mcwi blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17076 381
FHH-Chr 1BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 15 450.47 beats/min 8.58 33.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20949 381
FHH-Chr 1BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 12 18.22 mmHg 2.88 9.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20744 381
FHH-Chr 1BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 269.0 U/l 8.94 26.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36405 401
FHH-Chr 1BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 482.19 beats/min 14.03 37.11 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15974 381
FHH-Chr 1BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 107.11 breaths/min 4.86 18.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14950 381
FHH-Chr 1BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 10 66.89 mg/d 9.22 29.15 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52140 482
FHH-Chr 1BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 9 1.3 ml/min 0.18 0.54 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52385 482
FHH-Chr 1BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 68.56 mg/d 16.62 52.55 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52415 482
FHH-Chr 1BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 37.81 degrees C 0.38 1.06 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17646 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood carbon dioxide air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 9 -6.23 mmHg 0.45 1.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19660 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood carbon dioxide air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -5.77 mmHg 0.62 1.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19681 381
FHH-Chr 1BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 47.81 ml/min 2.7 11.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18677 381
FHH-Chr 1BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 40.16 ml/min 2.01 8.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18688 381
FHH-Chr 1BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 18 143.94 mmol/l 0.46 1.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36542 401
FHH-Chr 1BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 18 9.51 mg/dl 0.11 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36811 401
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 61.21 mmHg 0.96 2.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20524 381
FHH-Chr 1BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 122.51 breaths/min 6.35 25.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18291 381
FHH-Chr 1BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 15 -0.11 degrees C 0.15 0.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20335 381
FHH-Chr 1BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 154.6 g 7.1 22.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49561 461
FHH-Chr 1BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 15 110.27 mmol/l 1.08 4.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39132 401
FHH-Chr 1BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 3.78 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42259 401
FHH-Chr 1BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 18 20.28 mmol/l 0.46 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43208 401
FHH-Chr 1BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 18 4.13 mmol/l 0.09 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43404 401
FHH-Chr 1BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 15 1.81 g/dl 0.04 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40565 401
FHH-Chr 1BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 1.68 g/dl 0.06 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40576 401
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 1.72 mg/kg 0.49 1.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59241 526
FHH-Chr 1BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 4.11 x 1000 cells/ul 0.44 1.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40952 401
FHH-Chr 1BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 18 137.72 mg/dl 4.1 17.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41271 401
FHH-Chr 1BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 18 8.07 mg/dl 0.19 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37904 401
FHH-Chr 1BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 14 46.29 % 0.49 1.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41379 401
FHH-Chr 1BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 14 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41481 401
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 15.45 ml/min/kg 0.91 2.87 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57826 526
FHH-Chr 1BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.51 ml 0.02 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16488 381
FHH-Chr 1BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 39.16 ml/min/kg 3.94 16.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58278 526
FHH-Chr 1BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 18 203.7 g 5.5 23.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58390 526
FHH-Chr 1BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 0.05 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56244 522
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 13 2.78 mg/kg 0.54 1.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58921 526
FHH-Chr 1BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 17 1.61 E-7mole 0.35 1.44 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56586 522
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 23.0 % 6.2 18.61 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55068 522
FHH-Chr 1BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59940 526
FHH-Chr 1BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 -7.01 null 0.1 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56957 522
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 9.89 ml/min/kg 1.22 4.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60046 526
FHH-Chr 1BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 17 -6.9 null 0.07 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56981 522
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 6.96 ml/min/kg 1.0 3.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60071 526
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 44.22 % 2.4 7.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57191 522
FHH-Chr 1BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 4.59 g/kg 0.28 0.87 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47034 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.46 ml/min/g 0.9 2.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46885 461
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 148.32 mmHg 6.53 20.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45744 461
FHH-Chr 1BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 14.88 ml/min/g 1.14 3.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46668 461
FHH-Chr 1BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 271.35 beats/min 9.78 29.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48223 461
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 109.03 mmHg 3.72 11.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44841 461
FHH-Chr 1BN/Mcwi ratio of change in renal blood flow to change in renal perfusion pressure controlled in situ renal perfusion pressure (100-140 mmHg) Lopez B, et al., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22. renal blood flow trait male 140 days 12 0.19 null 0.05 0.17 ultrasonic flowmeter 0.0 0 69371 1156
FHH-Chr 1BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20172 381
FHH-Chr 1BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 42.73 ml/min 1.9 8.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20223 381
FHH-Chr 1BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 78.45 ml/min 3.87 14.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20776 381
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.34 mmHg 0.16 0.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49192 461
FHH-Chr 1BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 221.52 beats/min 13.46 40.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48971 461
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 114.81 mmHg 1.72 4.87 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15048 381
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 114.79 mmHg 1.65 5.48 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15062 381
FHH-Chr 1BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 171.74 breaths/min 5.86 21.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16937 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 12 129.06 mmHg 3.94 13.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18959 381
FHH-Chr 1BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.31 degrees C 0.19 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19084 381
FHH-Chr 1BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 %change=VE during7-9 min hypercapnia/control during standard conditions 123.09 % 5.97 23.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18569 381
FHH-Chr 1BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 143.73 % 7.23 30.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13695 381
FHH-Chr 1BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 10 19.31 mEq/d 1.16 3.66 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52809 482
FHH-Chr 1BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 9 4.77 g/kg 0.12 0.35 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47059 461
FHH-Chr 1BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 258.51 beats/min 7.81 24.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48212 461
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 40.17 mmHg 2.58 7.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47716 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 68.47 mmHg 3.87 11.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47937 461
FHH-Chr 1BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 42.22 mmHg 2.99 8.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48059 461
FHH-Chr 1BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 18 21.83 mmol/l 0.37 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43042 401
FHH-Chr 1BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 900.59 s 38.21 120.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49314 461
FHH-Chr 1BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 139.2 g 6.4 20.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49586 461
FHH-Chr 1BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 18 -8.5 null 0.12 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56032 522
FHH-Chr 1BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 0.61 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43250 401
FHH-Chr 1BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 18 41.5 % 5.45 23.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54846 522
FHH-Chr 1BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 13 56.87 % 0.59 2.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39006 401
FHH-Chr 1BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 19.89 mg/dl 1.18 3.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40854 401
FHH-Chr 1BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 18 68.94 U/l 3.29 13.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37784 401
FHH-Chr 1BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 18 94.67 U/l 4.54 19.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42494 401
FHH-Chr 1BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 9 4.7 mmol/l 0.15 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38092 401
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 32.49 mmHg 0.78 2.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 14469 381
FHH-Chr 1BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 9 0.35 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52289 482
FHH-Chr 1BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 7 2.39 ml/min 0.19 0.49 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52368 482
FHH-Chr 1BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 10 155.42 mmHg 4.94 15.62 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52577 482
FHH-Chr 1BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 350.86 beats/min 18.24 51.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14725 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 116.34 mmHg 5.47 14.47 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19912 381
FHH-Chr 1BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 17.31 mmHg 2.31 6.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20730 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 15 126.23 mmHg 3.6 13.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15120 381
FHH-Chr 1BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 411.96 beats/min 20.16 57.02 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15955 381
FHH-Chr 1BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 -0.36 degrees C 0.3 1.04 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16021 381
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 27.34 mmHg 0.66 1.85 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17289 381
FHH-Chr 1BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 154.97 breaths/min 4.51 16.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17137 381
FHH-Chr 1BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 37.89 degrees C 0.13 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18130 381
FHH-Chr 1BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 15 9.12 mg/dl 0.11 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36639 401
FHH-Chr 1BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 18 5.52 g/dl 0.05 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37275 401
FHH-Chr 1BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 251.12 beats/min 19.54 61.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48960 461
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.29 mmHg 0.19 0.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49203 461
FHH-Chr 1BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 10.78 % 4.5 14.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49713 461
FHH-Chr 1BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 890.95 s 27.06 81.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50134 461
FHH-Chr 1BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 946.07 s 60.82 192.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49325 461
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 103.64 mmHg 6.21 19.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49914 461
FHH-Chr 1BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 58.19 fl 0.41 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38771 401
FHH-Chr 1BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 14.89 mmol/l 0.7 2.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42088 401
FHH-Chr 1BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 14 127.93 U/l 10.54 39.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42785 401
FHH-Chr 1BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 124.99 % 5.18 21.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54344 381
FHH-Chr 1BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 18 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42960 401
FHH-Chr 1BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 185.35 % 9.04 35.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54443 381
FHH-Chr 1BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 18 21.39 mmol/l 0.54 2.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43183 401
FHH-Chr 1BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 13 0.28 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39689 401
FHH-Chr 1BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 12 15.1 g/dl 0.2 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40154 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 12 17.28 pg 0.09 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40250 401
FHH-Chr 1BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 18 3.95 g/dl 0.03 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40459 401
FHH-Chr 1BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 18 105.28 mmol/l 0.5 2.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40058 401
FHH-Chr 1BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 17 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59410 526
FHH-Chr 1BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.05 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59435 526
FHH-Chr 1BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 13 5.14 x 1000 cells/ul 0.51 1.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40941 401
FHH-Chr 1BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.79 g/kg 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59683 526
FHH-Chr 1BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 18 7.95 mg/dl 0.1 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37879 401
FHH-Chr 1BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 15 144.6 mg/dl 6.97 26.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38545 401
FHH-Chr 1BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 129.56 mg/dl 4.75 14.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38556 401
FHH-Chr 1BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 26.78 % 6.6 20.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48542 461
FHH-Chr 1BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 35.97 % 3.49 11.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48553 461
FHH-Chr 1BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.0 g 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45420 461
FHH-Chr 1BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 12 53.66 fl 0.21 0.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38699 401
FHH-Chr 1BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 14 56.02 fl 0.17 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38724 401
FHH-Chr 1BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 65.38 % 8.91 25.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57292 522
FHH-Chr 1BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.54 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55343 522
FHH-Chr 1BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 12 46.96 % 0.65 2.27 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57539 526
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 20.4 ml/min/kg 2.16 7.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57815 526
FHH-Chr 1BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 18 162.3 g 2.9 12.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58415 526
FHH-Chr 1BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 16 37.61 degrees C 0.13 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16838 381
FHH-Chr 1BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 35.13 ml/min/kg 4.71 14.89 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58303 526
FHH-Chr 1BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -8.24 null 0.06 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54623 522
FHH-Chr 1BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58515 526
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 20.38 % 3.17 12.67 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56287 522
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 24.78 % 5.89 17.66 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55147 522
FHH-Chr 1BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.27 null 0.01 0.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59849 526
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 19.0 % 4.19 12.58 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55059 522
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 16 7.06 % 2.26 9.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55087 522
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 9 33.98 mmHg 0.8 2.4 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16095 381
FHH-Chr 1BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 119.87 mmHg 4.19 12.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46765 461
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 40.56 mmHg 4.9 14.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47727 461
FHH-Chr 1BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 64.16 % 1.79 5.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46345 461
FHH-Chr 1BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 223.08 beats/min 5.09 16.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45174 461
FHH-Chr 1BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 47.68 % 2.98 9.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47092 461
FHH-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 54.91 % 3.73 11.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46092 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 39.82 mmHg 8.0 23.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45285 461
FHH-Chr 1BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 12 110.85 mmHg 3.17 10.97 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20066 381
FHH-Chr 1BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 75.26 ml/min 2.67 9.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20787 381
FHH-Chr 1BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 15 5.69 g/dl 0.07 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36977 401
FHH-Chr 1BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 65.33 mg/dl 2.05 6.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37123 401
FHH-Chr 1BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 %change=VE during7-9 min hypercapnia/control during standard conditions 237.27 % 10.25 38.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14224 381
FHH-Chr 1BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 127.52 breaths/min 6.5 27.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14809 381
FHH-Chr 1BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 %change=VE during 2-3 min hypoxia/control during standard conditions 135.29 % 4.94 19.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13706 381
FHH-Chr 1BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 18 143.89 mmol/l 0.4 1.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36567 401
FHH-Chr 1BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during 2-3 min hypercapnia/control during standard conditions 304.19 % 14.31 55.41 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19226 381
FHH-Chr 1BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 9 3.7 ng/ml/h 0.8 2.4 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52924 482
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.18 mmHg 0.24 0.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47223 461
FHH-Chr 1BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.5 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17385 381
FHH-Chr 1BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.49 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17396 381
FHH-Chr 1BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 7.06 ml/min/g 0.69 2.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44733 461
FHH-Chr 1BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 15 0.28 mg/dl 0.01 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39591 401
FHH-Chr 1BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 15 26.87 mmol/l 0.75 2.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38276 401
FHH-Chr 1BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 4.81 % 2.75 8.25 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49422 461
FHH-Chr 1BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 174.24 % 4.73 17.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54452 381
FHH-Chr 1BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1152.5 s 25.98 82.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46563 461
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 14 17.9 pg 0.08 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40275 401
FHH-Chr 1BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 241.58 beats/min 8.76 27.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47608 461
FHH-Chr 1BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 19 98.89 % 0.58 2.54 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56329 522
FHH-Chr 1BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 12 0.41 x 1000 cells/ul 0.06 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40346 401
FHH-Chr 1BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 28.69 ml/min 1.09 4.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16162 381
FHH-Chr 1BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 13 56.87 % 0.59 2.14 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59272 526
FHH-Chr 1BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 55.3 % 0.61 1.84 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59283 526
FHH-Chr 1BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 59.75 U/l 3.9 11.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40740 401
FHH-Chr 1BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 59.13 % 8.47 26.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48771 461
FHH-Chr 1BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 14 0.58 x 1000 cells/ul 0.07 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38973 401
FHH-Chr 1BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 9.51 x 10E6 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39263 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 18.62 pg 0.15 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42571 401
FHH-Chr 1BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 18 0.21 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57978 526
FHH-Chr 1BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 12 46.96 % 0.65 2.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41354 401
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 8.72 mmHg 2.11 6.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16303 381
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 103.58 mmHg 3.73 10.55 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16403 381
FHH-Chr 1BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 189.59 % 9.27 35.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54103 381
FHH-Chr 1BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 0.33 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13949 381
FHH-Chr 1BN/Mcwi blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17095 381
FHH-Chr 1BN/Mcwi absolute change in blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19812 381
FHH-Chr 1BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 106.74 % 3.08 13.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54004 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 -4.38 mmHg 0.92 2.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20100 381
FHH-Chr 1BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 99.39 breaths/min 6.41 25.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18436 381
FHH-Chr 1BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 12 4.81 x 1000 cells/ul 0.49 1.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36921 401
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 106.96 mmHg 2.73 8.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18895 381
FHH-Chr 1BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 10 440.48 beats/min 9.55 30.21 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52530 482
FHH-Chr 1BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 166.93 mmHg 4.8 14.41 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52560 482
FHH-Chr 1BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.35 mg/dl 0.03 0.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52272 482
FHH-Chr 1BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 410.56 beats/min 14.13 37.38 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14744 381
FHH-Chr 1BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 37.14 degrees C 0.21 0.79 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13585 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 15 121.71 mmHg 4.05 15.7 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14358 381
FHH-Chr 1BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20158 381
FHH-Chr 1BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20651 381
FHH-Chr 1BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 22 169.8 g 2.5 11.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17843 381
FHH-Chr 1BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 %change=VE during7-9 min hypercapnia/control during standard conditions 128.7 % 4.99 21.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18558 381
FHH-Chr 1BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 18 9.49 mg/dl 0.09 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36836 401
FHH-Chr 1BN/Mcwi heart rate air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 15 425.56 beats/min 14.49 56.12 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17531 381
FHH-Chr 1BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 129.74 breaths/min 5.56 23.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18280 381
FHH-Chr 1BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 43.4 mmHg 3.35 10.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50012 461
FHH-Chr 1BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 43.3 mmHg 2.9 9.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50023 461
FHH-Chr 1BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1125.69 s 42.89 135.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50242 461
FHH-Chr 1BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 18 0.19 mg/dl 0.01 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42723 401
FHH-Chr 1BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 80.38 U/l 3.22 9.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42796 401
FHH-Chr 1BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 18 105.56 mmol/l 0.49 2.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40083 401
FHH-Chr 1BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 18 1.11 g/kg 0.02 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59531 526
FHH-Chr 1BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 18 1.64 g/dl 0.05 0.21 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41104 401
FHH-Chr 1BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 18 15.11 mg/dl 0.9 3.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41829 401
FHH-Chr 1BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 18 73.17 mg/dl 1.06 4.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38485 401
FHH-Chr 1BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 146.91 mmHg 5.97 18.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48650 461
FHH-Chr 1BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 278.29 beats/min 12.74 40.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47597 461
FHH-Chr 1BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 12 8.76 x 10E6 cells/ul 0.12 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42021 401
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 116.03 mmHg 4.99 14.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45530 461
FHH-Chr 1BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 14 46.29 % 0.49 1.82 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57564 526
FHH-Chr 1BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 60.57 % 5.93 15.68 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57267 522
FHH-Chr 1BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 32 235.3 g 3.8 21.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55221 522
FHH-Chr 1BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 32 175.1 g 1.7 9.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55245 522
FHH-Chr 1BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 18 37.47 degrees C 0.16 0.67 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16587 381
FHH-Chr 1BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 15 37.46 degrees C 0.09 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16598 381
FHH-Chr 1BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.03 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55759 522
FHH-Chr 1BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 1.47 E-7mole 0.41 1.15 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55962 522
FHH-Chr 1BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 1.11 g/mg 0.14 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55831 522
FHH-Chr 1BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -8.32 null 0.22 0.66 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54633 522
FHH-Chr 1BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.03 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54717 522
FHH-Chr 1BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 19 0.03 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56254 522
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 23.86 % 4.82 18.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56297 522
FHH-Chr 1BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 14 41.57 % 5.87 21.97 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54822 522
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 19.67 % 5.56 16.68 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55156 522
FHH-Chr 1BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 0.84 E-7mole 0.09 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56562 522
FHH-Chr 1BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 0.38 null 0.03 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59824 526
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 9.5 ml/min/kg 1.31 4.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58700 526
FHH-Chr 1BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 14 44.14 % 5.69 21.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57160 522
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 152.1 mmHg 6.15 19.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45755 461
FHH-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 55.37 % 3.7 11.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46081 461
FHH-Chr 1BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 49.61 % 2.83 8.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47103 461
FHH-Chr 1BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 95.53 % 9.46 29.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48310 461
FHH-Chr 1BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 119.63 % 8.05 32.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53780 381
FHH-Chr 1BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 9 0.74 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49086 461
FHH-Chr 1BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 136.82 % 6.12 22.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54246 381
FHH-Chr 1BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 0.35 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15248 381
FHH-Chr 1BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 heart rate during walking-heart rate during rest 91.08 beats/min 15.45 43.71 vascular fluid filled catheter 0 0 Moms and pups used in studies were fed Teklad 13398 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 115.24 mmHg 4.79 12.67 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13531 381
FHH-Chr 1BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 -0.01 null 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14763 381
FHH-Chr 1BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 5.46 g/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36988 401
FHH-Chr 1BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 14 72.64 mg/dl 4.1 15.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37112 401
FHH-Chr 1BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 8.91 mg/dl 0.11 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36650 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 12 32.2 g/dl 0.11 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37380 401
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 7.05 ml/min/g 0.94 2.97 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46216 461
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -52.91 mmHg 4.32 11.43 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19512 381
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 7.15 ml/min/g 0.93 2.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46227 461
FHH-Chr 1BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.47 g/kg 0.24 0.76 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45659 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 53.5 mmHg 6.47 20.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45296 461
FHH-Chr 1BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 9 155.8 g 7.2 21.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47881 461
FHH-Chr 1BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 18 0.2 mg/dl 0.01 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42698 401
FHH-Chr 1BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.41 null 0.04 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58128 526
FHH-Chr 1BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 12 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41456 401
FHH-Chr 1BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 13 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41662 401
FHH-Chr 1BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 30.16 ml/min 1.72 6.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16716 381
FHH-Chr 1BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 12 6.38 x 1000 cells/ul 0.64 2.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39937 401
FHH-Chr 1BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 924.55 s 40.3 113.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50145 461
FHH-Chr 1BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 14 14.79 g/dl 0.15 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40179 401
FHH-Chr 1BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.27 null 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58759 526
FHH-Chr 1BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 14 0.31 x 1000 cells/ul 0.05 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40371 401
FHH-Chr 1BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 13 23.15 mg/dl 0.86 3.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40843 401
FHH-Chr 1BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 99.78 % 0.22 0.67 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56489 522
FHH-Chr 1BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 18 101.11 U/l 5.73 24.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42469 401
FHH-Chr 1BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 18 0.23 null 0.01 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57953 526
FHH-Chr 1BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 5.31 mmol/l 0.11 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38081 401
FHH-Chr 1BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 15 146.2 mmol/l 0.69 2.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39403 401