Phenominer Database Results (406 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 18BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.24 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15405 381
FHH-Chr 18BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 141.79 % 9.33 24.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54228 381
FHH-Chr 18BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 150.56 % 11.05 31.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54098 381
FHH-Chr 18BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 149.3 breaths/min 9.53 26.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17121 381
FHH-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 117.0 % 9.15 30.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53766 381
FHH-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 101.3 breaths/min 4.15 11.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18418 381
FHH-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 75.4 mg/dl 1.38 4.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37105 401
FHH-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 9 424.91 mg/d 55.78 167.35 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52111 482
FHH-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 9 48.46 mg/d 29.49 88.47 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52406 482
FHH-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 7 0.43 mg/dl 0.05 0.14 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52260 482
FHH-Chr 18BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 125.97 mmHg 6.67 14.92 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13500 381
FHH-Chr 18BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.23 ml 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17992 381
FHH-Chr 18BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.46 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20639 381
FHH-Chr 18BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 154.38 breaths/min 4.8 12.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16919 381
FHH-Chr 18BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 377.11 U/l 24.44 73.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37487 401
FHH-Chr 18BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 126.12 % 10.63 35.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18553 381
FHH-Chr 18BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.51 g/dl 0.07 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37238 401
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 388.29 beats/min 19.22 54.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17519 381
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 403.49 beats/min 13.9 43.95 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17522 381
FHH-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 121.98 breaths/min 3.25 9.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18273 381
FHH-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 123.21 breaths/min 5.35 17.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18275 381
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 5.98 mmHg 0.18 0.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49185 461
FHH-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.46 degrees C 0.3 0.9 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20317 381
FHH-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 -0.37 degrees C 0.29 0.99 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20319 381
FHH-Chr 18BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.5 mmol/l 0.34 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36530 401
FHH-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1116.67 s 46.15 138.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50237 461
FHH-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.82 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42241 401
FHH-Chr 18BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.37 x 1000 cells/ul 0.04 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38936 401
FHH-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 87.8 U/l 3.21 10.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42780 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.78 pg 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42555 401
FHH-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 143.3 mmol/l 0.63 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39396 401
FHH-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 117.53 % 8.71 28.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54339 381
FHH-Chr 18BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 27.1 mmol/l 0.6 1.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43030 401
FHH-Chr 18BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 157.51 % 3.5 9.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54434 381
FHH-Chr 18BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.08 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42923 401
FHH-Chr 18BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.24 x 1000 cells/ul 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40331 401
FHH-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 52.82 % 0.71 2.24 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59265 526
FHH-Chr 18BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 6.36 x 1000 cells/ul 0.54 1.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40936 401
FHH-Chr 18BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.05 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59494 526
FHH-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59557 526
FHH-Chr 18BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 16.81 g/dl 0.23 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37976 401
FHH-Chr 18BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 53.8 U/l 4.24 13.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37747 401
FHH-Chr 18BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 134.5 mg/dl 3.68 11.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41234 401
FHH-Chr 18BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 80.6 mg/dl 1.59 5.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38473 401
FHH-Chr 18BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41444 401
FHH-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41878 401
FHH-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 43.14 % 2.38 6.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48535 461
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 26.85 ml/min/kg 1.84 5.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57808 526
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -8.38 null 0.05 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55306 522
FHH-Chr 18BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.37 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16483 381
FHH-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.21 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57941 526
FHH-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.45 null 0.03 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58121 526
FHH-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.26 E-7mole 0.13 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55925 522
FHH-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 1.47 g/mg 0.12 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55819 522
FHH-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 84.33 % 3.7 11.1 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54808 522
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 27.56 ml/min/kg 1.33 4.19 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58663 526
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.7 null 0.17 0.53 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56133 522
FHH-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58497 526
FHH-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.15 E-7mole 0.33 1.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56548 522
FHH-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59925 526
FHH-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -7.05 null 0.1 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56943 522
FHH-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.94 null 0.1 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56946 522
FHH-Chr 18BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.37 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17378 381
FHH-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 38.59 mmHg 1.27 3.58 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16086 381
FHH-Chr 18BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 164.5 g 6.1 19.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47841 461
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 5.32 mmHg 0.23 0.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47207 461
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 54.75 mmHg 5.1 15.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47919 461
FHH-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 126.26 % 11.14 31.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53762 381
FHH-Chr 18BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 214.51 beats/min 7.9 23.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48955 461
FHH-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -7.44 mmHg 0.71 2.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19651 381
FHH-Chr 18BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 9 229.6 g 5.6 16.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17825 381
FHH-Chr 18BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.25 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15407 381
FHH-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 64.4 mg/dl 1.28 4.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37107 401
FHH-Chr 18BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 4.49 x 1000 cells/ul 0.74 2.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36906 401
FHH-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 31.15 mmHg 1.21 3.43 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17259 381
FHH-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 8 36.92 degrees C 0.4 1.12 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19079 381
FHH-Chr 18BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 9 64.77 mg/d 14.16 42.49 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52114 482
FHH-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 70.46 % 4.52 6.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46327 461
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 221.71 beats/min 17.32 51.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45158 461
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 48.66 mmHg 6.9 20.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45280 461
FHH-Chr 18BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 16.7 mmol/l 0.83 2.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38271 401
FHH-Chr 18BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 151.1 mg/dl 2.39 7.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38538 401
FHH-Chr 18BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 59.82 ml/min/kg 4.54 11.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58266 526
FHH-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 22.16 % 6.2 18.59 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49406 461
FHH-Chr 18BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 897.8 s 39.67 125.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50129 461
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 263.05 beats/min 5.53 16.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47590 461
FHH-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 0.47 null 0.01 0.03 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59809 526
FHH-Chr 18BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 43.63 % 1.53 4.58 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57524 526
FHH-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 20.91 ml/min 1.04 2.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16157 381
FHH-Chr 18BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 8.44 mg/dl 0.28 0.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37864 401
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 15.12 ml/min/kg 0.82 2.59 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60034 526
FHH-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 9 11.86 mEq/d 2.45 7.36 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52797 482
FHH-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 109.35 % 8.6 24.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53995 381
FHH-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.03 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19800 381
FHH-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 426.2 U/l 8.94 28.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36387 401
FHH-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 4.98 g/dl 0.09 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36972 401
FHH-Chr 18BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 53.18 ml/min 2.53 7.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14510 381
FHH-Chr 18BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 36.63 degrees C 0.27 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13569 381
FHH-Chr 18BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 10.11 mg/dl 0.12 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36799 401
FHH-Chr 18BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 0.7 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49070 461
FHH-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -43.07 mmHg 2.52 7.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19479 381
FHH-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1061.11 s 41.12 123.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50235 461
FHH-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 908.33 s 39.95 119.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49309 461
FHH-Chr 18BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.17 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42686 401
FHH-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 122.0 % 6.72 19.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54335 381
FHH-Chr 18BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 1.05 x 1000 cells/ul 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43232 401
FHH-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.36 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39684 401
FHH-Chr 18BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 4.08 x 1000 cells/ul 0.34 1.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39925 401
FHH-Chr 18BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 103.89 mmol/l 0.35 1.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40043 401
FHH-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 62.7 U/l 1.56 4.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40722 401
FHH-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.25 g/dl 0.05 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40560 401
FHH-Chr 18BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.7 mg/dl 1.0 3.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40836 401
FHH-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59398 526
FHH-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.83 mmol/l 0.22 0.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38074 401
FHH-Chr 18BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 93.0 mg/dl 2.67 8.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38470 401
FHH-Chr 18BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 6.61 x 1000 cells/ul 0.58 1.83 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41511 401
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 55.82 mmHg 3.46 10.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46425 461
FHH-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.05 g/mg 0.15 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57365 522
FHH-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 12 36.97 degrees C 0.22 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16822 381
FHH-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 1.02 g/mg 0.09 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55816 522
FHH-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.62 E-7mole 0.25 0.76 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55922 522
FHH-Chr 18BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 5.31 g/kg 0.23 0.72 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47019 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 6.91 ml/min/g 0.73 2.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44728 461
FHH-Chr 18BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 44.11 mmHg 3.23 9.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48041 461
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.12 mmHg 0.36 1.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47205 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.11 ml/min/g 1.45 4.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46209 461
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 60.02 % 6.32 18.97 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46074 461
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 64.56 % 4.81 14.42 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46076 461
FHH-Chr 18BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 42.6 mmHg 5.84 18.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48043 461
FHH-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 49.66 mmHg 1.67 4.72 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20491 381
FHH-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 27.96 ml/min 3.12 10.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20218 381
FHH-Chr 18BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 58.21 ml/min 6.93 18.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14508 381
FHH-Chr 18BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.24 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17990 381
FHH-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 32.34 mmHg 0.71 2.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17256 381
FHH-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.26 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13931 381
FHH-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.43 mg/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36634 401
FHH-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 7 1.07 ml/min 0.15 0.39 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52356 482
FHH-Chr 18BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 256.24 beats/min 11.52 36.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48207 461
FHH-Chr 18BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.36 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17380 381
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.4 IU/g 0.07 0.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47338 461
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 47.39 mmHg 4.75 14.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45278 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 28.17 IU/g 2.11 4.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45986 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 23.98 IU/g 2.79 7.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45988 461
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 101.37 mmHg 6.98 20.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44823 461
FHH-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 118.02 % 6.61 19.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44926 461
FHH-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.49 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58123 526
FHH-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39586 401
FHH-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.06 degrees C 0.2 0.6 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16580 381
FHH-Chr 18BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 169.8 g 4.1 12.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58378 526
FHH-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 12.45 % 3.33 9.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49404 461
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.92 g/dl 0.12 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39787 401
FHH-Chr 18BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 17.78 mmol/l 0.66 1.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43168 401
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.83 null 0.18 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56136 522
FHH-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 12.95 % 4.63 13.9 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49708 461
FHH-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.82 g 0.06 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45415 461
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 106.35 mmHg 5.35 7.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45512 461
FHH-Chr 18BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 55.4 fl 0.31 0.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38687 401
FHH-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41876 401
FHH-Chr 18BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 7.86 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42009 401
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 122.97 mmHg 2.67 7.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48632 461
FHH-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 39.33 mmHg 2.23 6.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50007 461
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 246.83 beats/min 12.12 36.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47592 461
FHH-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 136.5 g 3.2 10.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59072 526
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 20.88 ml/min/kg 1.75 4.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58660 526
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.94 mg/kg 0.38 1.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59204 526
FHH-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 83.12 % 5.23 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48766 461
FHH-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.45 null 0.02 0.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59812 526
FHH-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 49.08 % 0.91 2.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39001 401
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 25.73 IU/g 1.59 4.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48883 461
FHH-Chr 18BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 7.45 mg/dl 0.24 0.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37867 401
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 30.02 ml/min/kg 1.35 4.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57810 526
FHH-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.17 mmol/l 0.17 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38076 401
FHH-Chr 18BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 158.06 % 11.7 30.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54094 381
FHH-Chr 18BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 12 171.2 g 3.0 10.4 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17827 381
FHH-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.25 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15241 381
FHH-Chr 18BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 -0.46 degrees C 0.22 0.62 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15677 381
FHH-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 8 1.02 ml/min 0.14 0.41 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52359 482
FHH-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 8 162.82 mmHg 9.3 26.3 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52551 482
FHH-Chr 18BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 119.71 mmHg 3.16 7.73 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13503 381
FHH-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 104.39 % 3.28 10.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53898 381
FHH-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 105.57 % 5.74 19.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53999 381
FHH-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 124.11 mmHg 2.15 5.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19884 381
FHH-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.48 mg/dl 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36632 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.72 g/dl 0.14 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37368 401
FHH-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 864.67 s 36.4 109.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49307 461
FHH-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 108.6 mmol/l 0.4 1.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39127 401
FHH-Chr 18BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 0.83 x 1000 cells/ul 0.11 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38933 401
FHH-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 21.1 mmol/l 0.95 3.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42070 401
FHH-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 21.8 mmol/l 1.31 4.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42072 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.32 pg 0.13 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42553 401
FHH-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.19 x 10E6 cells/ul 0.15 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39245 401
FHH-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 93.7 U/l 3.95 12.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42778 401
FHH-Chr 18BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 26.11 mmol/l 0.87 2.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43027 401
FHH-Chr 18BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 145.23 % 8.45 23.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54438 381
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.29 pg 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40235 401
FHH-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59395 526
FHH-Chr 18BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.05 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41441 401
FHH-Chr 18BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 14.67 mg/dl 0.9 2.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41789 401
FHH-Chr 18BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 13.6 mg/dl 0.48 1.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41792 401
FHH-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 41.06 % 5.71 15.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48537 461
FHH-Chr 18BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1133.44 s 31.34 94.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46556 461
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -8.1 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55303 522
FHH-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 25.5 ml/min 2.42 6.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16155 381
FHH-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 62.96 ml/min/kg 3.87 12.23 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58009 526
FHH-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 36.59 degrees C 0.19 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16582 381
FHH-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.38 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58743 526
FHH-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 37.83 mmHg 1.19 3.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16083 381
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 128.04 mmHg 2.79 7.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45737 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 13.17 ml/min/g 0.66 1.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46663 461
FHH-Chr 18BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 7.15 g/kg 0.48 1.43 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45644 461
FHH-Chr 18BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 5.18 g/kg 0.3 0.94 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47022 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 5.89 ml/min/g 0.27 0.81 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46211 461
FHH-Chr 18BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 400.95 beats/min 13.32 42.11 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20940 381
FHH-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -5.49 mmHg 1.22 3.45 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19648 381
FHH-Chr 18BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during7-9 min hypercapnia/control during standard conditions 265.01 % 27.16 76.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14208 381
FHH-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17067 381
FHH-Chr 18BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 143.11 mmol/l 0.31 0.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36527 401
FHH-Chr 18BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 233.6 U/l 10.77 34.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37490 401
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 51.44 % 4.07 12.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47085 461
FHH-Chr 18BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 9 0.66 mEq/d 0.11 0.33 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52312 482
FHH-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 182.05 mmHg 4.28 12.83 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52548 482
FHH-Chr 18BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 264.24 beats/min 8.38 25.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48205 461
FHH-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 51.93 % 8.37 14.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46329 461
FHH-Chr 18BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 7.53 g/kg 0.26 0.77 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45647 461
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 125.18 mmHg 4.42 11.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45739 461
FHH-Chr 18BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 85.41 % 3.93 11.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48414 461
FHH-Chr 18BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 10 137.4 g 7.5 23.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47844 461
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 116.87 mmHg 6.77 11.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46760 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.42 ml/min/g 0.51 1.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46880 461
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 91.19 mmHg 10.57 31.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44825 461
FHH-Chr 18BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 145.1 mg/dl 4.33 13.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38540 401
FHH-Chr 18BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 16.3 mmol/l 0.67 2.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43171 401
FHH-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 11.06 % 4.49 13.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49706 461
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 103.21 mmHg 4.61 13.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49896 461
FHH-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 39.44 mmHg 2.22 6.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50005 461
FHH-Chr 18BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 14.0 g/dl 0.47 1.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40139 401
FHH-Chr 18BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.2 mmol/l 0.08 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43367 401
FHH-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 109.7 g 7.8 24.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49549 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.15 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47471 461
FHH-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 83.52 % 1.7 4.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48764 461
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 17.41 ml/min/kg 1.04 2.95 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57606 526
FHH-Chr 18BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 64.0 U/l 3.73 11.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37744 401
FHH-Chr 18BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 -0.3 degrees C 0.17 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15679 381
FHH-Chr 18BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 409.46 beats/min 15.5 37.97 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15946 381
FHH-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.24 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15243 381
FHH-Chr 18BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 383.94 beats/min 22.36 50.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15943 381
FHH-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 126.74 mmHg 3.35 9.48 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15108 381
FHH-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 8 0.35 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52263 482
FHH-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 9 8.89 mEq/d 1.85 5.54 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52800 482
FHH-Chr 18BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 398.65 beats/min 21.36 52.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14716 381
FHH-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 108.08 breaths/min 7.72 20.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14943 381
FHH-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 83.06 breaths/min 2.11 5.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14945 381
FHH-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 121.71 breaths/min 9.21 30.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14804 381
FHH-Chr 18BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 180.56 % 12.46 35.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54232 381
FHH-Chr 18BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 149.85 breaths/min 6.43 17.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17119 381
FHH-Chr 18BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 56.18 ml/min 5.18 13.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20769 381
FHH-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19803 381
FHH-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 128.88 mmHg 5.13 11.48 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19881 381
FHH-Chr 18BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 96.12 breaths/min 4.52 14.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18420 381
FHH-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 333.1 U/l 12.96 41.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36389 401
FHH-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 8 37.01 degrees C 0.25 0.69 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19077 381
FHH-Chr 18BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during7-9 min hypercapnia/control during standard conditions 138.41 % 16.75 47.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18551 381
FHH-Chr 18BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 5.39 g/dl 0.08 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37235 401
FHH-Chr 18BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 10.32 mg/dl 0.14 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36796 401
FHH-Chr 18BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 %change=VE during 2-3 min hypercapnia/control during standard conditions 233.01 % 27.22 72.02 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19219 381
FHH-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 27.76 ml/min 1.78 5.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18672 381
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 5.19 mmHg 0.36 1.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49187 461
FHH-Chr 18BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.87 g 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49068 461
FHH-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 30.82 ml/min 1.33 3.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20216 381
FHH-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 -44.32 mmHg 1.81 5.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19482 381
FHH-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.73 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42243 401
FHH-Chr 18BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.22 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42683 401
FHH-Chr 18BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 5.64 x 1000 cells/ul 0.85 2.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39922 401
FHH-Chr 18BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42920 401
FHH-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39584 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 31.84 g/dl 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39785 401
FHH-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 161.4 g 6.8 21.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59070 526
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 17.55 pg 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40238 401
FHH-Chr 18BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 4.52 mmol/l 0.1 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43364 401
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.32 mg/kg 0.19 0.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58914 526
FHH-Chr 18BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.12 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40334 401
FHH-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.46 g/dl 0.05 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40558 401
FHH-Chr 18BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 140.25 mg/dl 3.63 10.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41231 401
FHH-Chr 18BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 43.63 % 1.53 4.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41339 401
FHH-Chr 18BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 43.53 % 0.56 1.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41342 401
FHH-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59555 526
FHH-Chr 18BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.54 g/dl 0.03 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41067 401
FHH-Chr 18BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 8.22 x 1000 cells/ul 0.65 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40934 401
FHH-Chr 18BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1119.6 s 39.72 125.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46558 461
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 18.79 ml/min/kg 1.01 3.2 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57608 526
FHH-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -6.83 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55653 522
FHH-Chr 18BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.37 ml 0.04 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16481 381
FHH-Chr 18BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.6 degrees C 0.17 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16820 381
FHH-Chr 18BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 9 212.0 g 6.8 20.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58375 526
FHH-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 24.23 ml/min 2.54 7.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16698 381
FHH-Chr 18BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 21.95 ml/min 0.91 3.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16700 381
FHH-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.0 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54705 522
FHH-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.43 E-7mole 0.36 1.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56551 522
FHH-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.09 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59928 526
FHH-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 73.89 % 8.2 24.61 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57252 522
FHH-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 69.56 % 4.56 13.68 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57255 522
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 52.71 mmHg 5.36 16.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47921 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 7.21 ml/min/g 0.71 2.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44726 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 8.26 ml/min/g 0.51 1.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46878 461
FHH-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 89.29 % 4.55 13.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48305 461
FHH-Chr 18BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 54.58 ml/min 5.14 14.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20771 381
FHH-Chr 18BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 144.33 breaths/min 8.28 23.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16921 381
FHH-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 123.08 mmHg 3.41 9.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14346 381
FHH-Chr 18BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 92.74 mmHg 2.43 6.88 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18883 381
FHH-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 31.95 ml/min 2.4 6.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18670 381
FHH-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.23 ml 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13933 381
FHH-Chr 18BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 79.22 mg/d 28.78 86.34 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52403 482
FHH-Chr 18BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 442.33 beats/min 16.64 49.92 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52501 482
FHH-Chr 18BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 80.53 % 2.64 7.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48416 461
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 100.75 mmHg 5.25 7.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46758 461
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 38.48 mmHg 7.46 22.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47711 461
FHH-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 97.04 % 11.86 35.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44928 461
FHH-Chr 18BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41657 401
FHH-Chr 18BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.87 x 1000 cells/ul 0.21 0.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43234 401
FHH-Chr 18BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 53.88 fl 0.41 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38684 401
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 100.96 mmHg 4.91 14.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49898 461
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.31 mg/kg 0.29 0.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58916 526
FHH-Chr 18BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 103.4 mmol/l 0.27 0.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40046 401
FHH-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.03 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54937 522
FHH-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 56.8 U/l 2.26 7.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40724 401
FHH-Chr 18BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 1.12 g/mg 0.1 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57362 522
FHH-Chr 18BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 43.53 % 0.56 1.77 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57527 526
FHH-Chr 18BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.48 mg/dl 0.18 0.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37604 401
FHH-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 49.08 % 0.91 2.87 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59267 526
FHH-Chr 18BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 21.2 mg/dl 1.11 3.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40838 401
FHH-Chr 18BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 126.2 mmHg 2.82 8.92 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15111 381
FHH-Chr 18BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 334.68 beats/min 15.4 34.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14713 381
FHH-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 137.99 % 11.08 31.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13688 381
FHH-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 125.9 breaths/min 8.59 24.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14802 381
FHH-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 4.81 ng/ml/h 0.78 2.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52895 482
FHH-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 8 10.07 ng/ml/h 1.37 3.87 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52898 482
FHH-Chr 18BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 %change=VE during7-9 min hypercapnia/control during standard conditions 223.0 % 14.44 38.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14206 381
FHH-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 127.52 mmHg 2.78 8.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14349 381
FHH-Chr 18BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 373.53 beats/min 10.07 28.47 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20937 381
FHH-Chr 18BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.42 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20642 381
FHH-Chr 18BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 95.9 mmHg 2.27 6.42 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18886 381
FHH-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.28 g/dl 0.08 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36970 401
FHH-Chr 18BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 3.56 x 1000 cells/ul 0.33 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36909 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 32.09 g/dl 0.1 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37365 401
FHH-Chr 18BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during 2-3 min hypercapnia/control during standard conditions 258.09 % 16.95 47.94 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19221 381
FHH-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 117.8 g 5.4 17.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49546 461
FHH-Chr 18BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 943.33 s 38.3 114.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50127 461
FHH-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 52.82 % 0.71 2.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38999 401
FHH-Chr 18BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 91.89 U/l 5.4 16.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42454 401
FHH-Chr 18BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 95.89 U/l 6.08 18.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42457 401
FHH-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 109.0 mmol/l 0.56 1.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39125 401
FHH-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 57.49 fl 0.44 1.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38753 401
FHH-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 58.85 fl 0.29 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38755 401
FHH-Chr 18BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 13.81 g/dl 0.16 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40142 401
FHH-Chr 18BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 148.03 % 14.26 37.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53643 381
FHH-Chr 18BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 174.55 % 11.06 31.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53647 381
FHH-Chr 18BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 8.04 mg/dl 0.22 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37602 401
FHH-Chr 18BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 9 1.07 g/kg 0.08 0.25 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59491 526
FHH-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.56 g/kg 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59665 526
FHH-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.71 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59667 526
FHH-Chr 18BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 1.57 g/dl 0.03 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41064 401
FHH-Chr 18BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 15.67 g/dl 0.28 0.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37978 401
FHH-Chr 18BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41655 401
FHH-Chr 18BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 18.2 mmol/l 0.7 2.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38269 401
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 52.3 mmHg 3.71 11.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46427 461
FHH-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.84 g 0.07 0.21 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45413 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.21 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47474 461
FHH-Chr 18BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 250.0 g 3.9 12.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55208 522
FHH-Chr 18BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 174.3 g 2.1 6.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55210 522
FHH-Chr 18BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 224.7 beats/min 10.33 30.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48953 461
FHH-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.92 null 0.04 0.13 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55656 522
FHH-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 8 0.22 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57938 526
FHH-Chr 18BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 172.1 g 2.3 7.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55445 522
FHH-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 59.72 ml/min/kg 2.38 6.73 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58007 526
FHH-Chr 18BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 44.45 ml/min/kg 3.76 9.21 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58263 526
FHH-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58499 526
FHH-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 83.0 % 6.92 20.75 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54811 522
FHH-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.38 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58741 526
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 12.0 ml/min/kg 0.97 2.74 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60031 526
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 14.1 ml/min/g 0.81 2.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46661 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.43 IU/g 0.03 0.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47335 461
FHH-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 102.42 % 24.44 73.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48303 461
FHH-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 112.63 % 5.52 15.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53894 381
FHH-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 51.58 mmHg 1.45 4.11 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20494 381
FHH-Chr 18BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 36.55 degrees C 0.13 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13567 381
FHH-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17064 381
FHH-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 127.89 % 8.47 28.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13690 381
FHH-Chr 18BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 9 0.9 mEq/d 0.11 0.32 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52309 482
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 52.01 % 4.08 12.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47087 461
FHH-Chr 18BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 8 415.13 beats/min 8.11 22.93 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52504 482
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 267.31 beats/min 62.35 187.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45156 461
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 46.62 mmHg 3.04 9.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47709 461
FHH-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.55 x 1000 cells/ul 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39682 401
FHH-Chr 18BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 5.13 x 1000 cells/ul 0.4 1.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41513 401
FHH-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54702 522
FHH-Chr 18BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 8.09 x 10E6 cells/ul 0.22 0.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42006 401
FHH-Chr 18BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.82 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40444 401
FHH-Chr 18BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.97 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40447 401
FHH-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.04 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54934 522
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 120.05 mmHg 5.37 10.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45514 461
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 2.1 mg/kg 0.42 1.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59201 526
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 120.42 mmHg 4.11 10.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48634 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 25.4 IU/g 2.75 8.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48885 461
FHH-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.34 x 10E6 cells/ul 0.17 0.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39247 401
FHH-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.8 mmol/l 0.79 2.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39398 401
FHH-Chr 18BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 230.5 g 5.6 17.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55442 522