Phenominer Database Results (406 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 17BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 148.7 % 11.84 39.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13727 381
FHH-Chr 17BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 125.79 % 8.32 24.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13729 381
FHH-Chr 17BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 118.27 % 9.17 30.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53931 381
FHH-Chr 17BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 102.65 % 2.59 7.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53933 381
FHH-Chr 17BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 56.64 ml/min 5.24 15.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20808 381
FHH-Chr 17BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 117.43 % 6.05 18.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53801 381
FHH-Chr 17BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 6 67.17 mg/dl 1.85 4.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37143 401
FHH-Chr 17BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 6 5.05 g/dl 0.06 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37010 401
FHH-Chr 17BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.25 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15444 381
FHH-Chr 17BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.27 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15446 381
FHH-Chr 17BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 388.44 beats/min 20.8 50.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15918 381
FHH-Chr 17BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 10 151.8 mg/d 21.71 68.65 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52417 482
FHH-Chr 17BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 15 253.09 mg/d 36.79 142.49 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52126 482
FHH-Chr 17BN/Mcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 136.03 mmHg 9.09 27.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14320 381
FHH-Chr 17BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 126.23 mmHg 6.6 16.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13475 381
FHH-Chr 17BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 10 172.2 g 5.8 18.2 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17866 381
FHH-Chr 17BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 11 214.0 g 2.4 8.1 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17864 381
FHH-Chr 17BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.45 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20613 381
FHH-Chr 17BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.74 degrees C 0.26 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19116 381
FHH-Chr 17BN/Mcwi heart rate air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 425.96 beats/min 24.66 73.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17493 381
FHH-Chr 17BN/Mcwi heart rate air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 418.05 beats/min 9.42 26.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17497 381
FHH-Chr 17BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 109.39 % 6.15 18.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18592 381
FHH-Chr 17BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 10.17 mg/dl 0.15 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36768 401
FHH-Chr 17BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 17 39.0 mmHg 2.99 12.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50043 461
FHH-Chr 17BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 6 57.8 fl 0.33 0.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38791 401
FHH-Chr 17BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 8.46 x 10E6 cells/ul 0.23 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39285 401
FHH-Chr 17BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42895 401
FHH-Chr 17BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 122.68 % 7.55 22.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54374 381
FHH-Chr 17BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 105.22 mmol/l 1.19 3.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40015 401
FHH-Chr 17BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 18.44 mmol/l 1.06 3.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43140 401
FHH-Chr 17BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 6 8.87 mg/dl 0.19 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37640 401
FHH-Chr 17BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 8.1 mg/dl 0.15 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37836 401
FHH-Chr 17BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 137.89 mg/dl 3.56 10.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41206 401
FHH-Chr 17BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.31 g/dl 0.05 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41039 401
FHH-Chr 17BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 6 5.02 x 1000 cells/ul 0.38 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41549 401
FHH-Chr 17BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.49 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59782 526
FHH-Chr 17BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 6 17.5 mmol/l 1.69 4.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38307 401
FHH-Chr 17BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 53.5 fl 0.21 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38656 401
FHH-Chr 17BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.63 degrees C 0.25 0.82 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16619 381
FHH-Chr 17BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 168.9 g 3.3 10.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58350 526
FHH-Chr 17BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 67.0 % 6.65 21.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54780 522
FHH-Chr 17BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 52.39 mmHg 9.88 29.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47957 461
FHH-Chr 17BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 10.3 ml/min/g 0.29 1.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46699 461
FHH-Chr 17BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 39.11 mmHg 3.83 11.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48079 461
FHH-Chr 17BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 44.25 mmHg 9.11 25.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48081 461
FHH-Chr 17BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 151.18 % 9.59 28.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54131 381
FHH-Chr 17BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 28.14 ml/min 2.76 8.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20257 381
FHH-Chr 17BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 0.16 degrees C 0.25 0.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20356 381
FHH-Chr 17BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 6 64.33 mg/dl 1.89 4.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37145 401
FHH-Chr 17BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 4.21 x 1000 cells/ul 0.39 1.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36878 401
FHH-Chr 17BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 3.37 x 1000 cells/ul 0.33 1.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36881 401
FHH-Chr 17BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 150.92 breaths/min 6.79 20.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17160 381
FHH-Chr 17BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 6 9.93 mg/dl 0.11 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36670 401
FHH-Chr 17BN/Mcwi absolute change in blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.04 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19774 381
FHH-Chr 17BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 246.78 % 11.49 34.48 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19258 381
FHH-Chr 17BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 202.22 % 14.26 42.77 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19260 381
FHH-Chr 17BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 242.32 beats/min 7.67 21.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48245 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 17 0.26 IU/g 0.06 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47447 461
FHH-Chr 17BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 87.0 % 6.0 18.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57227 522
FHH-Chr 17BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 215.43 beats/min 14.01 57.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45194 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 72.41 % 4.51 13.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46112 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 73.52 % 6.79 17.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46114 461
FHH-Chr 17BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 121.47 % 12.42 37.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44964 461
FHH-Chr 17BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 6 0.42 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39720 401
FHH-Chr 17BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 6 4.14 x 1000 cells/ul 0.49 1.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41551 401
FHH-Chr 17BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 17 12.84 % 2.61 10.76 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49744 461
FHH-Chr 17BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 13.31 g/dl 0.25 0.74 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40111 401
FHH-Chr 17BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 12.86 g/dl 0.19 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40114 401
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 106.5 mmHg 1.3 1.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45550 461
FHH-Chr 17BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 155.2 g 2.5 7.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59110 526
FHH-Chr 17BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 251.8 g 6.8 21.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55182 522
FHH-Chr 17BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.09 mmHg x min x kg x ml-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59897 526
FHH-Chr 17BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 6 25.17 mg/dl 2.56 6.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40874 401
FHH-Chr 17BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 6 145.0 mmol/l 0.52 1.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39434 401
FHH-Chr 17BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 110.4 breaths/min 4.15 13.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14841 381
FHH-Chr 17BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 10 14.04 mEq/d 2.22 7.02 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52811 482
FHH-Chr 17BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 11 4.02 ng/ml/h 0.58 1.93 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52910 482
FHH-Chr 17BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 8 187.06 mmHg 10.19 28.82 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52562 482
FHH-Chr 17BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 12 173.37 mmHg 6.04 20.93 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52563 482
FHH-Chr 17BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 15 81.65 mg/d 11.38 44.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52418 482
FHH-Chr 17BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.26 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13972 381
FHH-Chr 17BN/Mcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 28.59 mmHg 1.08 3.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17231 381
FHH-Chr 17BN/Mcwi partial pressure of blood carbon dioxide (Pco2) air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 29.95 mmHg 0.79 2.25 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17235 381
FHH-Chr 17BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 143.07 mmHg 9.43 28.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15082 381
FHH-Chr 17BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 229.91 % 15.45 46.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14245 381
FHH-Chr 17BN/Mcwi mean arterial blood pressure air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 128.35 mmHg 6.12 17.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14324 381
FHH-Chr 17BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 54.91 ml/min 2.68 8.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20810 381
FHH-Chr 17BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 109.96 % 5.04 16.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53799 381
FHH-Chr 17BN/Mcwi absolute change in blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19778 381
FHH-Chr 17BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 161.37 breaths/min 12.15 36.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16958 381
FHH-Chr 17BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.42 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20617 381
FHH-Chr 17BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 336.22 U/l 16.79 50.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37459 401
FHH-Chr 17BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.2 degrees C 0.19 0.57 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19118 381
FHH-Chr 17BN/Mcwi partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 53.36 mmHg 2.14 6.06 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20469 381
FHH-Chr 17BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 915.25 s 111.89 316.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50167 461
FHH-Chr 17BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 104.44 U/l 6.8 20.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42429 401
FHH-Chr 17BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 6 21.67 mmol/l 1.63 3.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42108 401
FHH-Chr 17BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 9.4 x 10E6 cells/ul 0.1 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39283 401
FHH-Chr 17BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 3.76 x 1000 cells/ul 0.34 1.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39897 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 31.95 g/dl 0.12 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39823 401
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.36 mg/kg 0.27 0.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58952 526
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.32 mg/kg 0.36 1.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58954 526
FHH-Chr 17BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 4.57 mmol/l 0.14 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43336 401
FHH-Chr 17BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 6 1.25 g/dl 0.04 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40598 401
FHH-Chr 17BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 6 66.67 U/l 7.21 17.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40760 401
FHH-Chr 17BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.83 g/kg 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59705 526
FHH-Chr 17BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.18 g/kg 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59466 526
FHH-Chr 17BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 79.3 mg/dl 1.33 4.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38445 401
FHH-Chr 17BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 16.0 mg/dl 1.25 3.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41761 401
FHH-Chr 17BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 41.3 % 0.84 2.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41311 401
FHH-Chr 17BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 39.77 % 0.5 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41314 401
FHH-Chr 17BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41413 401
FHH-Chr 17BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 56.24 fl 0.26 0.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38659 401
FHH-Chr 17BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 6 16.83 mmol/l 1.51 3.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38309 401
FHH-Chr 17BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 46.16 % 6.4 20.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48573 461
FHH-Chr 17BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 39.77 % 0.5 1.5 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57499 526
FHH-Chr 17BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.93 null 0.09 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55278 522
FHH-Chr 17BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.93 null 0.08 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55628 522
FHH-Chr 17BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 61.09 ml/min/kg 4.69 14.84 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58045 526
FHH-Chr 17BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 204.0 g 8.8 27.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55416 522
FHH-Chr 17BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.38 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16522 381
FHH-Chr 17BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.67 degrees C 0.3 0.95 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16621 381
FHH-Chr 17BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 1.03 E-7mole 0.19 0.58 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55894 522
FHH-Chr 17BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 8 207.6 g 4.0 11.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58347 526
FHH-Chr 17BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -8.11 null 0.09 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56105 522
FHH-Chr 17BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 3.36 E-7mole 2.05 6.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56520 522
FHH-Chr 17BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.54 null 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58779 526
FHH-Chr 17BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -6.87 null 0.04 0.12 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56915 522
FHH-Chr 17BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.37 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17419 381
FHH-Chr 17BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 10 139.0 g 1.8 5.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47816 461
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 126.83 mmHg 4.56 16.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45777 461
FHH-Chr 17BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 10.42 ml/min/g 0.33 1.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46701 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.09 ml/min/g 0.36 1.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46247 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 8.52 ml/min/g 0.42 1.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46916 461
FHH-Chr 17BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 5.18 g/kg 0.19 0.59 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46990 461
FHH-Chr 17BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 79.68 % 2.2 3.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46365 461
FHH-Chr 17BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 129.48 mmHg 7.3 17.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19860 381
FHH-Chr 17BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.25 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18031 381
FHH-Chr 17BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 93.31 % 2.73 8.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54034 381
FHH-Chr 17BN/Mcwi blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.46 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17042 381
FHH-Chr 17BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 94.79 mmHg 3.86 10.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18861 381
FHH-Chr 17BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 143.56 mmol/l 0.75 2.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36499 401
FHH-Chr 17BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 10 538.16 mg/d 64.09 202.66 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52125 482
FHH-Chr 17BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 10 1.18 mEq/d 0.1 0.3 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52323 482
FHH-Chr 17BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 232.65 beats/min 10.34 31.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48243 461
FHH-Chr 17BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 130.47 % 34.69 91.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48454 461
FHH-Chr 17BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 5.44 ml/min/g 0.38 1.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44764 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 39.78 mmHg 5.42 16.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47747 461
FHH-Chr 17BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 6 100.0 U/l 5.85 14.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42818 401
FHH-Chr 17BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 19 945.84 s 44.39 193.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49347 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 6.01 mmHg 0.16 0.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49223 461
FHH-Chr 17BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 6 0.04 x 1000 cells/ul 0.03 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41693 401
FHH-Chr 17BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 7.03 x 10E6 cells/ul 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41981 401
FHH-Chr 17BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 181.0 g 4.5 14.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59108 526
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.54 mg/kg 0.7 1.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59174 526
FHH-Chr 17BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 146.0 % 9.8 29.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53682 381
FHH-Chr 17BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 187.1 g 6.3 19.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55185 522
FHH-Chr 17BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 6 58.58 fl 0.07 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38793 401
FHH-Chr 17BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 6 49.17 U/l 4.32 10.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40762 401
FHH-Chr 17BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 70.33 U/l 5.11 15.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37716 401
FHH-Chr 17BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 49.57 % 1.33 3.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39039 401
FHH-Chr 17BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 54.32 % 0.44 1.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39037 401
FHH-Chr 17BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59595 526
FHH-Chr 17BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 106.71 breaths/min 6.74 20.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14984 381
FHH-Chr 17BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15282 381
FHH-Chr 17BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 56.53 ml/min 3.17 9.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14549 381
FHH-Chr 17BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 159.8 % 11.9 35.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54265 381
FHH-Chr 17BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 423.0 beats/min 15.29 43.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20915 381
FHH-Chr 17BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 6 5.23 g/dl 0.04 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37008 401
FHH-Chr 17BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.09 g/dl 0.09 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37210 401
FHH-Chr 17BN/Mcwi absolute change in partial pressure of blood carbon dioxide air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -7.35 mmHg 0.79 2.23 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19627 381
FHH-Chr 17BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.98 mg/dl 0.17 0.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36771 401
FHH-Chr 17BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.09 degrees C 0.24 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20358 381
FHH-Chr 17BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 38.7 ml/min 3.2 10.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18709 381
FHH-Chr 17BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 1179.29 s 30.51 125.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50273 461
FHH-Chr 17BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 905.11 s 55.06 165.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50165 461
FHH-Chr 17BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 4.38 % 2.12 6.37 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49442 461
FHH-Chr 17BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 9.9 % 6.38 18.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49444 461
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 18.47 pg 0.11 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42591 401
FHH-Chr 17BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.18 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42658 401
FHH-Chr 17BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 6 110.17 mmol/l 0.79 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39165 401
FHH-Chr 17BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 6 111.0 U/l 9.75 23.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42816 401
FHH-Chr 17BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.08 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42892 401
FHH-Chr 17BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.9 g/dl 0.08 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40416 401
FHH-Chr 17BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 104.5 mmol/l 0.7 2.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40018 401
FHH-Chr 17BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 7 0.03 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59367 526
FHH-Chr 17BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 6 54.32 % 0.44 1.07 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59303 526
FHH-Chr 17BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 17.35 g/dl 0.15 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38014 401
FHH-Chr 17BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 6 4.5 mmol/l 0.36 0.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38114 401
FHH-Chr 17BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 14.5 mg/dl 0.75 2.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41764 401
FHH-Chr 17BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 6 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41916 401
FHH-Chr 17BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 1.15 g 0.07 0.3 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45451 461
FHH-Chr 17BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 20 1.02 g 0.05 0.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45453 461
FHH-Chr 17BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 41.3 % 0.84 2.51 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57496 526
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 18.47 ml/min/kg 0.97 3.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57646 526
FHH-Chr 17BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 8 0.22 null 0.0 0.01 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57910 526
FHH-Chr 17BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 53.94 ml/min/kg 4.37 13.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58047 526
FHH-Chr 17BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.02 g/mg 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55791 522
FHH-Chr 17BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.43 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58159 526
FHH-Chr 17BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.2 E-7mole 0.35 1.05 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55897 522
FHH-Chr 17BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 46.79 ml/min/kg 2.54 6.73 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58236 526
FHH-Chr 17BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 56.47 ml/min/kg 3.05 9.16 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58239 526
FHH-Chr 17BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58535 526
FHH-Chr 17BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 33.64 mmHg 1.33 3.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16058 381
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 10.92 ml/min/g 1.27 3.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46918 461
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 122.08 mmHg 4.5 14.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45775 461
FHH-Chr 17BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 20 6.9 g/kg 0.31 1.39 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45619 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 53.38 % 3.75 15.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47123 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 19 0.27 IU/g 0.02 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47450 461
FHH-Chr 17BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 31.25 ml/min 2.29 7.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20255 381
FHH-Chr 17BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 130.51 mmHg 8.41 23.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15086 381
FHH-Chr 17BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.26 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18029 381
FHH-Chr 17BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 153.13 breaths/min 10.01 30.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17158 381
FHH-Chr 17BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.7 mmol/l 0.6 1.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36502 401
FHH-Chr 17BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 88.44 % 4.26 12.77 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57224 522
FHH-Chr 17BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 5.36 ml/min/g 0.38 1.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44766 461
FHH-Chr 17BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 102.33 % 14.41 38.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44966 461
FHH-Chr 17BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.38 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16520 381
FHH-Chr 17BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 4.97 x 1000 cells/ul 0.41 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39894 401
FHH-Chr 17BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.58 degrees C 0.24 0.74 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16861 381
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 6.12 mmHg 0.1 0.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49225 461
FHH-Chr 17BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54677 522
FHH-Chr 17BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54909 522
FHH-Chr 17BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.14 g/mg 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57337 522
FHH-Chr 17BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.28 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38908 401
FHH-Chr 17BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 6 22.17 mmol/l 1.78 4.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42110 401
FHH-Chr 17BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 96.21 % 12.87 48.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48804 461
FHH-Chr 17BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59593 526
FHH-Chr 17BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 60.9 U/l 2.0 6.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37719 401
FHH-Chr 17BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 120.14 breaths/min 7.52 22.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14843 381
FHH-Chr 17BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 6 0.61 mg/dl 0.09 0.21 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52274 482
FHH-Chr 17BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 11 0.52 mg/dl 0.05 0.15 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52275 482
FHH-Chr 17BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 11 0.76 ml/min 0.11 0.37 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52371 482
FHH-Chr 17BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 12 433.19 beats/min 8.02 27.79 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52516 482
FHH-Chr 17BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 7 0.68 ng/ml/h 0.16 0.42 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52909 482
FHH-Chr 17BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 199.8 % 18.71 56.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14247 381
FHH-Chr 17BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 389.45 beats/min 21.49 64.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20911 381
FHH-Chr 17BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 101.48 breaths/min 3.93 13.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18457 381
FHH-Chr 17BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 103.48 breaths/min 6.48 19.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18459 381
FHH-Chr 17BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 96.74 breaths/min 3.37 10.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14982 381
FHH-Chr 17BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.03 degrees C 0.19 0.57 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15716 381
FHH-Chr 17BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 351.92 beats/min 14.8 36.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14688 381
FHH-Chr 17BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 146.07 % 11.01 33.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54267 381
FHH-Chr 17BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.31 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13970 381
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 32.24 g/dl 0.12 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37337 401
FHH-Chr 17BN/Mcwi absolute change in partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -42.29 mmHg 2.8 7.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19453 381
FHH-Chr 17BN/Mcwi partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 52.75 mmHg 2.36 6.68 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20465 381
FHH-Chr 17BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 1179.79 s 46.27 201.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50275 461
FHH-Chr 17BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 20 169.7 g 3.6 16.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49518 461
FHH-Chr 17BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 19 39.26 mmHg 2.44 10.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50045 461
FHH-Chr 17BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 100.33 U/l 5.55 16.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42426 401
FHH-Chr 17BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 6 110.67 mmol/l 0.49 1.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39163 401
FHH-Chr 17BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 24.33 mmol/l 1.44 4.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42999 401
FHH-Chr 17BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 26.22 mmol/l 0.7 2.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43002 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 32.03 g/dl 0.16 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39825 401
FHH-Chr 17BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 136.35 % 5.93 17.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54473 381
FHH-Chr 17BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 17.6 mmol/l 1.08 3.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43143 401
FHH-Chr 17BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 6 0.3 mg/dl 0.03 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39622 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 18.18 pg 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40210 401
FHH-Chr 17BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.17 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40303 401
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.69 mg/kg 0.57 1.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59177 526
FHH-Chr 17BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.78 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40419 401
FHH-Chr 17BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 167.65 % 12.98 38.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53680 381
FHH-Chr 17BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 6 4.83 x 1000 cells/ul 0.58 1.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40974 401
FHH-Chr 17BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 142.67 mg/dl 5.41 16.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41203 401
FHH-Chr 17BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 15.87 g/dl 0.38 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38016 401
FHH-Chr 17BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 243.5 beats/min 4.85 20.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47628 461
FHH-Chr 17BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 236.15 beats/min 6.55 28.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47630 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 48.56 mmHg 3.7 14.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46465 461
FHH-Chr 17BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 43.73 % 7.11 23.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48575 461
FHH-Chr 17BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 -7.92 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55275 522
FHH-Chr 17BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 24.7 ml/min 1.83 5.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16194 381
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 17.33 ml/min/kg 0.48 1.51 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57644 526
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 25.45 ml/min/kg 1.09 3.45 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57846 526
FHH-Chr 17BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.53 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58161 526
FHH-Chr 17BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 25.96 ml/min 2.17 6.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16739 381
FHH-Chr 17BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.98 null 0.07 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56108 522
FHH-Chr 17BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.09 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59900 526
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 13.61 ml/min/kg 0.95 2.52 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60003 526
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 15.11 ml/min/kg 0.64 1.92 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60006 526
FHH-Chr 17BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -6.86 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56918 522
FHH-Chr 17BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.37 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17417 381
FHH-Chr 17BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 37.94 mmHg 11.8 31.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47959 461
FHH-Chr 17BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 5.25 g/kg 0.2 0.63 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46994 461
FHH-Chr 17BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 103.35 mmHg 7.65 10.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46798 461
FHH-Chr 17BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 6.79 g/kg 0.43 1.91 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45616 461
FHH-Chr 17BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 162.7 g 7.7 24.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47812 461
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 92.17 mmHg 9.58 28.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44861 461
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 78.54 mmHg 13.44 35.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44863 461
FHH-Chr 17BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 48.52 mmHg 6.4 25.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45318 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.55 IU/g 0.14 0.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47310 461
FHH-Chr 17BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 439.14 beats/min 13.69 33.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15922 381
FHH-Chr 17BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 398.39 beats/min 12.64 30.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14692 381
FHH-Chr 17BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 14 11.64 mEq/d 1.13 4.21 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52812 482
FHH-Chr 17BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 8 404.47 beats/min 25.87 73.18 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52515 482
FHH-Chr 17BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 1 post-ischemic value/pre-ischemic value x 100% 34.23 % balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46367 461
FHH-Chr 17BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 216.36 beats/min 35.27 141.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45196 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 40.6 mmHg 11.29 29.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47749 461
FHH-Chr 17BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 6 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39624 401
FHH-Chr 17BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 6 0.03 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41695 401
FHH-Chr 17BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 26.3 ml/min 1.42 4.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16737 381
FHH-Chr 17BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54674 522
FHH-Chr 17BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 17 10.56 % 2.37 9.77 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49746 461
FHH-Chr 17BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1134.0 s 50.07 150.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46594 461
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 26.96 ml/min/kg 0.87 2.6 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58635 526
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 93.31 mmHg 8.42 33.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49936 461
FHH-Chr 17BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 7.72 x 10E6 cells/ul 0.15 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41978 401
FHH-Chr 17BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 121.83 mmHg 4.63 16.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48672 461
FHH-Chr 17BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 0.49 x 1000 cells/ul 0.06 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38905 401
FHH-Chr 17BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.28 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15280 381
FHH-Chr 17BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.3 degrees C 0.3 0.9 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15718 381
FHH-Chr 17BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 61.04 ml/min 5.71 17.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14547 381
FHH-Chr 17BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 109.07 % 5.02 16.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54032 381
FHH-Chr 17BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 140.52 % 9.46 28.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54133 381
FHH-Chr 17BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 130.38 mmHg 6.47 15.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19856 381
FHH-Chr 17BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 95.04 mmHg 4.44 12.55 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18857 381
FHH-Chr 17BN/Mcwi blood pH air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17038 381
FHH-Chr 17BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 127.07 breaths/min 3.95 13.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18312 381
FHH-Chr 17BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 6 397.0 U/l 34.66 84.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36425 401
FHH-Chr 17BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 6 273.5 U/l 9.04 22.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36427 401
FHH-Chr 17BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 5.32 g/dl 0.14 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37207 401
FHH-Chr 17BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 14 0.99 mEq/d 0.05 0.2 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52324 482
FHH-Chr 17BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 6 0.89 ml/min 0.26 0.64 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52370 482
FHH-Chr 17BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 122.43 mmHg 5.96 14.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13479 381
FHH-Chr 17BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.78 degrees C 0.3 0.91 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13606 381
FHH-Chr 17BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.9 degrees C 0.34 1.01 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13608 381
FHH-Chr 17BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 151.67 breaths/min 6.99 20.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16960 381
FHH-Chr 17BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 119.41 % 6.66 22.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18590 381
FHH-Chr 17BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 32.09 ml/min 2.73 8.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18711 381
FHH-Chr 17BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 213.1 U/l 12.87 40.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37462 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 32.31 g/dl 0.2 0.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37340 401
FHH-Chr 17BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 251.8 beats/min 35.62 106.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48991 461
FHH-Chr 17BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 311.97 beats/min 77.02 203.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48993 461
FHH-Chr 17BN/Mcwi absolute change in partial pressure of blood oxygen air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 -41.44 mmHg 2.97 8.41 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19457 381
FHH-Chr 17BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.84 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49106 461
FHH-Chr 17BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 0.73 g 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49108 461
FHH-Chr 17BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 6 3.8 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42281 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 18.73 pg 0.09 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42593 401
FHH-Chr 17BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 6 0.22 x 1000 cells/ul 0.04 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39722 401
FHH-Chr 17BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 126.2 % 3.86 12.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54372 381
FHH-Chr 17BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 145.62 % 6.75 20.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54471 381
FHH-Chr 17BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.07 x 1000 cells/ul 0.02 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40306 401
FHH-Chr 17BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.19 mmol/l 0.26 0.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43339 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.23 pg 0.03 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40207 401
FHH-Chr 17BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 6 1.32 g/dl 0.02 0.04 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40596 401
FHH-Chr 17BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 6 6.15 x 1000 cells/ul 0.36 0.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40972 401
FHH-Chr 17BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59370 526
FHH-Chr 17BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 6 8.5 mg/dl 0.48 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37642 401
FHH-Chr 17BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 6 4.8 mmol/l 0.14 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38112 401
FHH-Chr 17BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 8 1.01 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59463 526
FHH-Chr 17BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 7.76 mg/dl 0.27 0.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37839 401
FHH-Chr 17BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 1.42 g/dl 0.06 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41036 401
FHH-Chr 17BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41416 401
FHH-Chr 17BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.48 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59785 526
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 52.93 mmHg 5.07 20.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46463 461
FHH-Chr 17BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 6 0.08 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41914 401
FHH-Chr 17BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 6 120.67 mg/dl 7.45 18.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38578 401
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 18.48 IU/g 2.99 7.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48861 461
FHH-Chr 17BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 29.1 ml/min 2.72 8.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16196 381
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 27.54 ml/min/kg 1.48 4.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57848 526
FHH-Chr 17BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.23 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57913 526
FHH-Chr 17BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 1.03 g/mg 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55788 522
FHH-Chr 17BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58537 526
FHH-Chr 17BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.02 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54906 522
FHH-Chr 17BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 86.0 % 3.59 11.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54783 522
FHH-Chr 17BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.48 E-7mole 0.19 0.61 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56523 522
FHH-Chr 17BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 37.3 mmHg 1.32 3.74 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16062 381
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 17 20.0 IU/g 2.15 8.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45970 461
FHH-Chr 17BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 100.8 mmHg 1.3 1.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46796 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 52.79 % 4.3 17.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47125 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 15 5.29 mmHg 0.22 0.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47243 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 5.14 mmHg 0.24 1.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47245 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 7.86 ml/min/g 1.03 2.73 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46249 461
FHH-Chr 17BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 43.84 mmHg 6.58 27.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45316 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.54 IU/g 0.08 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47306 461
FHH-Chr 17BN/Mcwi absolute change in partial pressure of blood carbon dioxide air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -5.05 mmHg 0.92 2.6 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19623 381
FHH-Chr 17BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 124.69 breaths/min 6.84 20.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18314 381
FHH-Chr 17BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 6 9.68 mg/dl 0.15 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36672 401
FHH-Chr 17BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 87.67 % 4.63 19.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48341 461
FHH-Chr 17BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 93.49 % 15.85 63.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48343 461
FHH-Chr 17BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 110.11 % 16.44 49.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48452 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 17 19.74 IU/g 2.1 8.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45967 461
FHH-Chr 17BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -7.03 null 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55625 522
FHH-Chr 17BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 17 941.65 s 25.06 103.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49345 461
FHH-Chr 17BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.46 degrees C 0.17 0.57 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16859 381
FHH-Chr 17BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 6 0.67 x 1000 cells/ul 0.08 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43270 401
FHH-Chr 17BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 6 0.45 x 1000 cells/ul 0.12 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43272 401
FHH-Chr 17BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 6 136.83 mg/dl 3.79 9.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38576 401
FHH-Chr 17BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 20 148.1 g 2.4 10.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49521 461
FHH-Chr 17BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 81.67 mg/dl 2.17 6.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38442 401
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 109.25 mmHg 7.75 10.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45552 461
FHH-Chr 17BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1132.0 s 110.77 313.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46596 461
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 22.96 ml/min/kg 1.4 3.71 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58632 526
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 92.9 mmHg 7.5 30.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49934 461
FHH-Chr 17BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 117.37 mmHg 4.73 14.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48670 461
FHH-Chr 17BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 93.7 % 8.26 33.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48802 461
FHH-Chr 17BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.49 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58781 526
FHH-Chr 17BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 6 24.5 mg/dl 0.72 1.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40876 401
FHH-Chr 17BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 6 49.57 % 1.33 3.26 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59305 526
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 21.8 IU/g 2.06 6.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48858 461
FHH-Chr 17BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.67 g/mg 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57334 522
FHH-Chr 17BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.61 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59703 526
FHH-Chr 17BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 6 3.92 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42279 401
FHH-Chr 17BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.19 mg/dl 0.01 0.03 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42655 401
FHH-Chr 17BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 6 144.5 mmol/l 0.56 1.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39436 401
FHH-Chr 17BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 173.8 g 4.6 14.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55419 522