Phenominer Database Results (372 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 15BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 139.81 % 8.21 24.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54259 381
FHH-Chr 15BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 139.69 breaths/min 5.02 15.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17151 381
FHH-Chr 15BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 125.44 % 13.37 40.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53793 381
FHH-Chr 15BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 77.5 mg/dl 2.09 5.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37125 401
FHH-Chr 15BN/Mcwi serum total cholesterol level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 69.88 mg/dl 2.78 7.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37136 401
FHH-Chr 15BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 145.72 breaths/min 7.78 23.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18305 381
FHH-Chr 15BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 57.73 ml/min 3.51 11.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14528 381
FHH-Chr 15BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 9 383.93 beats/min 7.94 23.83 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52485 482
FHH-Chr 15BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 2.92 ng/ml/h 0.71 2.13 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52879 482
FHH-Chr 15BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 9 160.32 mmHg 5.98 17.94 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52532 482
FHH-Chr 15BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 9 21.01 mEq/d 1.52 4.55 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52781 482
FHH-Chr 15BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.1 mg/dl 0.29 0.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36663 401
FHH-Chr 15BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 242.0 U/l 11.04 31.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37451 401
FHH-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 208.41 % 25.38 76.15 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19251 381
FHH-Chr 15BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 0.67 g 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49099 461
FHH-Chr 15BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 100.8 g 8.3 25.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49491 461
FHH-Chr 15BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 91.1 g 6.5 19.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49510 461
FHH-Chr 15BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 991.13 s 82.23 232.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49338 461
FHH-Chr 15BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 21.38 mmol/l 1.13 3.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42090 401
FHH-Chr 15BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.59 x 1000 cells/ul 0.19 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39713 401
FHH-Chr 15BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 1.27 x 1000 cells/ul 0.22 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43263 401
FHH-Chr 15BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 3.79 x 1000 cells/ul 0.25 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39886 401
FHH-Chr 15BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 126.71 % 5.71 18.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54355 381
FHH-Chr 15BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39604 401
FHH-Chr 15BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.07 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40295 401
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.04 mg/kg 0.49 1.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59166 526
FHH-Chr 15BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.8 g/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40408 401
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.81 pg 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40180 401
FHH-Chr 15BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.0 mmol/l 0.15 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43328 401
FHH-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59340 526
FHH-Chr 15BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 78.5 U/l 5.8 16.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40742 401
FHH-Chr 15BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 28.88 mg/dl 1.75 4.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40856 401
FHH-Chr 15BN/Mcwi serum urea nitrogen level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 26.0 mg/dl 1.78 5.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40867 401
FHH-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59586 526
FHH-Chr 15BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 130.25 mg/dl 3.69 10.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41195 401
FHH-Chr 15BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 7.5 x 1000 cells/ul 0.82 2.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41542 401
FHH-Chr 15BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 17.5 mmol/l 1.32 3.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38289 401
FHH-Chr 15BN/Mcwi plasma anion gap air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 18.25 mmol/l 1.93 5.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38300 401
FHH-Chr 15BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 18.38 mg/dl 1.25 3.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41753 401
FHH-Chr 15BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 100.23 mmHg 9.96 24.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48652 461
FHH-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 70.79 % 12.12 29.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48784 461
FHH-Chr 15BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 25.68 ml/min 2.05 6.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16175 381
FHH-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 -7.21 null 0.09 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55617 522
FHH-Chr 15BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.7 g/mg 0.08 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55780 522
FHH-Chr 15BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.93 degrees C 0.16 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16852 381
FHH-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 1.18 E-7mole 0.19 0.61 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55867 522
FHH-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 0.64 E-7mole 0.14 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55886 522
FHH-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.12 mmHg x min x kg x ml-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59870 526
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 13.76 ml/min/kg 1.04 3.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59995 526
FHH-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 -6.99 null 0.09 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56888 522
FHH-Chr 15BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 4.99 ml/min/g 1.16 2.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44757 461
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 45.6 mmHg 4.82 13.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47729 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 4.49 ml/min/g 1.16 3.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46240 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 83.15 mmHg 6.81 19.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44843 461
FHH-Chr 15BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 49.52 % 6.46 18.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46347 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.63 IU/g 0.15 0.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47298 461
FHH-Chr 15BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 87.45 % 7.1 17.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48334 461
FHH-Chr 15BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.69 g 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49088 461
FHH-Chr 15BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 210.27 beats/min 41.52 117.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48973 461
FHH-Chr 15BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 101.18 % 5.81 17.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54026 381
FHH-Chr 15BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.32 degrees C 0.17 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13599 381
FHH-Chr 15BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.32 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13963 381
FHH-Chr 15BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.04 g/dl 0.07 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37199 401
FHH-Chr 15BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 145.79 % 8.45 25.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13720 381
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 4.97 mmHg 0.33 0.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47225 461
FHH-Chr 15BN/Mcwi percent change in heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 73.44 % 8.2 23.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48323 461
FHH-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 8 89.13 % 5.45 15.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57216 522
FHH-Chr 15BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 5.72 g/kg 0.23 0.71 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46983 461
FHH-Chr 15BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.38 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16501 381
FHH-Chr 15BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.24 degrees C 0.27 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16600 381
FHH-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 197.99 beats/min 17.55 49.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47621 461
FHH-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54879 522
FHH-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.03 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54898 522
FHH-Chr 15BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1192.75 s 30.33 85.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50255 461
FHH-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 13 0.5 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58772 526
FHH-Chr 15BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 111.13 U/l 6.83 19.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42399 401
FHH-Chr 15BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.06 x 1000 cells/ul 0.02 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41386 401
FHH-Chr 15BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41405 401
FHH-Chr 15BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.35 g/dl 0.51 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38007 401
FHH-Chr 15BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 9 232.75 mg/d 44.36 133.08 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52095 482
FHH-Chr 15BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 7 2.41 ng/ml/h 0.58 1.53 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52900 482
FHH-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52244 482
FHH-Chr 15BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 9 2.36 ml/min 0.15 0.46 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52340 482
FHH-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 9 73.05 mg/d 23.6 70.81 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52387 482
FHH-Chr 15BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 149.14 breaths/min 5.49 17.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17139 381
FHH-Chr 15BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.26 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15425 381
FHH-Chr 15BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.3 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15273 381
FHH-Chr 15BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 128.03 % 11.54 36.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53782 381
FHH-Chr 15BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 103.68 % 3.99 11.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53925 381
FHH-Chr 15BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 10 223.9 g 5.0 15.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17845 381
FHH-Chr 15BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 106.27 breaths/min 8.94 26.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18450 381
FHH-Chr 15BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 348.38 U/l 7.8 22.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37432 401
FHH-Chr 15BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 36.73 degrees C 0.23 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19097 381
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 5.64 mmHg 0.21 0.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49216 461
FHH-Chr 15BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.43 degrees C 0.21 0.67 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20337 381
FHH-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 7.69 % 1.63 4.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49435 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 71.28 mmHg 10.11 24.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49916 461
FHH-Chr 15BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 54.43 % 0.88 2.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39019 401
FHH-Chr 15BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 54.14 % 1.65 4.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39030 401
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.63 pg 0.11 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42573 401
FHH-Chr 15BN/Mcwi blood neutrophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.35 x 1000 cells/ul 0.18 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43252 401
FHH-Chr 15BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 4.66 x 1000 cells/ul 0.24 0.68 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39867 401
FHH-Chr 15BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 25.75 mmol/l 0.56 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42972 401
FHH-Chr 15BN/Mcwi plasma creatinine level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.3 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39615 401
FHH-Chr 15BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 104.0 mmol/l 0.6 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39988 401
FHH-Chr 15BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 54.43 % 0.88 2.48 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59285 526
FHH-Chr 15BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 10.68 mg/dl 0.35 1.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37622 401
FHH-Chr 15BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 81.13 mg/dl 2.01 5.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38434 401
FHH-Chr 15BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.07 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41675 401
FHH-Chr 15BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 42.7 % 1.05 2.96 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41284 401
FHH-Chr 15BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.19 mg/dl 0.02 0.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41907 401
FHH-Chr 15BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 41.16 % 0.62 1.75 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57488 526
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 13.09 ml/min/kg 1.89 5.35 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57626 526
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 12.21 ml/min/kg 1.1 3.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57637 526
FHH-Chr 15BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 62.65 ml/min/kg 9.87 27.91 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58027 526
FHH-Chr 15BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 49.66 ml/min/kg 6.67 18.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58209 526
FHH-Chr 15BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 61.25 ml/min/kg 5.28 14.93 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58228 526
FHH-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.34 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58152 526
FHH-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.7 null 0.06 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56078 522
FHH-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.03 mmHg-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58517 526
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.42 mg/kg 0.72 2.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58934 526
FHH-Chr 15BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 9 166.6 g 3.2 9.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55175 522
FHH-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.1 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59889 526
FHH-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -7.07 null 0.07 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56907 522
FHH-Chr 15BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 76.64 mmHg 2.98 8.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46778 461
FHH-Chr 15BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 87.53 mmHg 7.83 22.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46789 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 105.2 mmHg 9.77 23.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45757 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 13.84 IU/g 1.68 4.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45960 461
FHH-Chr 15BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 30.67 mmHg 3.37 10.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48072 461
FHH-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 53.91 % 5.6 15.83 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46094 461
FHH-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 79.44 % 14.34 35.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44957 461
FHH-Chr 15BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 106.19 % 20.5 57.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48434 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.32 IU/g 0.12 0.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47421 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.43 IU/g 0.1 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47440 461
FHH-Chr 15BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.27 x 1000 cells/ul 0.24 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36870 401
FHH-Chr 15BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 45.53 ml/min 3.91 11.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18702 381
FHH-Chr 15BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 127.26 breaths/min 9.39 28.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14834 381
FHH-Chr 15BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 28.77 % 6.82 16.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46358 461
FHH-Chr 15BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 27.01 mmHg 7.1 17.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45298 461
FHH-Chr 15BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 128.4 g 4.8 15.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47786 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 8.2 ml/min/g 0.63 1.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46909 461
FHH-Chr 15BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 37.55 mmHg 5.03 14.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47939 461
FHH-Chr 15BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 104.63 U/l 7.35 20.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42809 401
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 40.89 mmHg 7.0 15.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46456 461
FHH-Chr 15BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 152.77 % 2.79 8.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53663 381
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 14.0 IU/g 1.53 4.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48850 461
FHH-Chr 15BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.82 g/mg 0.12 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57326 522
FHH-Chr 15BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 52.5 U/l 3.65 10.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37708 401
FHH-Chr 15BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 107.5 mmol/l 0.71 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39156 401
FHH-Chr 15BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.24 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42628 401
FHH-Chr 15BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.37 degrees C 0.14 0.44 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15697 381
FHH-Chr 15BN/Mcwi tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.29 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15261 381
FHH-Chr 15BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 149.44 % 3.1 9.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54248 381
FHH-Chr 15BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 150.51 % 7.76 24.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54114 381
FHH-Chr 15BN/Mcwi percent change in ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 141.45 % 6.54 20.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13708 381
FHH-Chr 15BN/Mcwi tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.34 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13951 381
FHH-Chr 15BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 61.22 ml/min 4.35 13.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20789 381
FHH-Chr 15BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 7 0.26 mg/dl 0.02 0.06 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52265 482
FHH-Chr 15BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.1 degrees C 0.22 0.69 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13587 381
FHH-Chr 15BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 151.93 breaths/min 3.31 10.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16939 381
FHH-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 123.78 % 6.17 19.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18571 381
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.81 g/dl 0.17 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37329 401
FHH-Chr 15BN/Mcwi serum calcium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 8.96 mg/dl 0.14 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36652 401
FHH-Chr 15BN/Mcwi absolute change in body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 0.24 degrees C 0.1 0.3 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20349 381
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 69.06 mmHg 6.29 14.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49927 461
FHH-Chr 15BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 24.5 mmHg 2.77 7.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50025 461
FHH-Chr 15BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 98.25 U/l 3.67 10.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42418 401
FHH-Chr 15BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.24 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42647 401
FHH-Chr 15BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.38 x 10E6 cells/ul 0.11 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39265 401
FHH-Chr 15BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 140.63 mmol/l 0.38 1.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39416 401
FHH-Chr 15BN/Mcwi serum sodium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 142.13 mmol/l 1.26 3.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39427 401
FHH-Chr 15BN/Mcwi serum aspartate aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 116.38 U/l 6.75 19.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42798 401
FHH-Chr 15BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42865 401
FHH-Chr 15BN/Mcwi blood monocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.4 x 1000 cells/ul 0.1 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39702 401
FHH-Chr 15BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42884 401
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.11 g/dl 0.18 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39805 401
FHH-Chr 15BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 110.6 g 4.8 15.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59090 526
FHH-Chr 15BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 8.34 x 1000 cells/ul 0.86 2.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40954 401
FHH-Chr 15BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 8.76 mg/dl 0.22 0.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37809 401
FHH-Chr 15BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.06 g/kg 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59455 526
FHH-Chr 15BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 133.25 mg/dl 2.83 8.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41176 401
FHH-Chr 15BN/Mcwi blood lymphocyte count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 6.52 x 1000 cells/ul 0.73 2.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41531 401
FHH-Chr 15BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 52.66 fl 0.17 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38629 401
FHH-Chr 15BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 31.21 % 5.65 12.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48566 461
FHH-Chr 15BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 178.1 g 6.7 21.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55392 522
FHH-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 69.86 % 3.8 8.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48795 461
FHH-Chr 15BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 32.88 ml/min 4.22 12.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16730 381
FHH-Chr 15BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 196.9 g 10.1 31.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58320 526
FHH-Chr 15BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 151.2 g 4.0 12.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58339 526
FHH-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.71 null 0.12 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56097 522
FHH-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58528 526
FHH-Chr 15BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 9 218.3 g 7.5 22.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55158 522
FHH-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.02 E-7mole 0.2 0.59 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56493 522
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 10.68 ml/min/kg 1.54 4.36 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59976 526
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 101.56 mmHg 8.69 22.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45768 461
FHH-Chr 15BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 9.99 ml/min/g 0.44 1.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46692 461
FHH-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 57.81 % 17.38 45.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46105 461
FHH-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 102.49 % 8.94 25.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44946 461
FHH-Chr 15BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 198.41 beats/min 17.67 49.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48225 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 65.45 mmHg 12.45 30.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44854 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.61 IU/g 0.15 0.42 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47279 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 4.47 ml/min/g 0.52 1.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46229 461
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 5.63 mmHg 0.47 1.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47236 461
FHH-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 159.17 beats/min 15.56 38.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45187 461
FHH-Chr 15BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.29 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15437 381
FHH-Chr 15BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 0.4 degrees C 0.21 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15709 381
FHH-Chr 15BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 454.5 U/l 16.52 46.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36407 401
FHH-Chr 15BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 141.88 mmol/l 0.61 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36491 401
FHH-Chr 15BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.92 degrees C 0.18 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19109 381
FHH-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 126.96 % 15.72 47.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18583 381
FHH-Chr 15BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.5 mmol/l 0.6 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36472 401
FHH-Chr 15BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.69 g/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36990 401
FHH-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 230.3 % 13.42 42.43 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19239 381
FHH-Chr 15BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 7 132.56 mmHg 2.89 7.65 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52553 482
FHH-Chr 15BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 13.47 ml/min/g 1.6 4.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46681 461
FHH-Chr 15BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 31.27 ml/min 1.54 4.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16718 381
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 18.03 ml/min/kg 1.95 5.52 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58605 526
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 44.27 mmHg 3.66 8.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46445 461
FHH-Chr 15BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 13.09 g/dl 0.18 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40103 401
FHH-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 223.66 beats/min 14.03 39.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47610 461
FHH-Chr 15BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 1014.25 s 42.59 120.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50147 461
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 21.25 ml/min/kg 2.4 7.2 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58624 526
FHH-Chr 15BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.93 null 0.05 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55598 522
FHH-Chr 15BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 102.91 breaths/min 7.48 22.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14975 381
FHH-Chr 15BN/Mcwi respiration rate air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 137.56 breaths/min 11.98 37.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14822 381
FHH-Chr 15BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 9 1.44 mEq/d 0.05 0.16 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52293 482
FHH-Chr 15BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 7 396.79 beats/min 11.52 30.48 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52506 482
FHH-Chr 15BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 7 37.96 mg/d 6.1 16.13 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52116 482
FHH-Chr 15BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 7 17.44 mEq/d 3.27 8.66 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52802 482
FHH-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 246.55 % 19.76 62.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14226 381
FHH-Chr 15BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 113.26 % 6.71 21.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53914 381
FHH-Chr 15BN/Mcwi serum alkaline phosphatase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 348.13 U/l 12.3 34.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36418 401
FHH-Chr 15BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 57.14 ml/min 4.82 14.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14540 381
FHH-Chr 15BN/Mcwi minute ventilation air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 44.14 ml/min 3.08 9.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18690 381
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 31.96 g/dl 0.1 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37310 401
FHH-Chr 15BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 37.87 ml/min 2.92 8.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20248 381
FHH-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 10.98 % 3.68 10.42 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49726 461
FHH-Chr 15BN/Mcwi heart contraction pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 23.88 mmHg 2.21 6.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50036 461
FHH-Chr 15BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 58.04 fl 0.53 1.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38773 401
FHH-Chr 15BN/Mcwi mean corpuscular volume air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 58.56 fl 0.8 2.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38784 401
FHH-Chr 15BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.33 g/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42272 401
FHH-Chr 15BN/Mcwi serum chloride level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 107.38 mmol/l 0.63 1.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39145 401
FHH-Chr 15BN/Mcwi red blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 9.25 x 10E6 cells/ul 0.22 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39276 401
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.76 pg 0.25 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42584 401
FHH-Chr 15BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 25.13 mmol/l 0.91 2.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42991 401
FHH-Chr 15BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 164.03 % 11.49 36.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54454 381
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.04 g/dl 0.17 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39816 401
FHH-Chr 15BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 16.88 mmol/l 0.35 0.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43113 401
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 3.81 mg/kg 0.73 1.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58945 526
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.21 pg 0.16 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40199 401
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 2.06 mg/kg 0.52 1.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59147 526
FHH-Chr 15BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 105.13 mmol/l 0.85 2.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40007 401
FHH-Chr 15BN/Mcwi total white blood cell count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 9.35 x 1000 cells/ul 1.09 3.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40965 401
FHH-Chr 15BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 41.16 % 0.62 1.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41303 401
FHH-Chr 15BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 8.59 mg/dl 0.15 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37828 401
FHH-Chr 15BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 5.11 mmol/l 0.36 1.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38105 401
FHH-Chr 15BN/Mcwi blood eosinophil count air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41686 401
FHH-Chr 15BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 17.25 mg/dl 1.39 3.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41734 401
FHH-Chr 15BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 124.75 mg/dl 5.5 15.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38558 401
FHH-Chr 15BN/Mcwi percent change in left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 27.96 % 7.47 18.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48555 461
FHH-Chr 15BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 7.62 x 10E6 cells/ul 0.12 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41970 401
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 81.96 mmHg 3.0 8.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45532 461
FHH-Chr 15BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1241.44 s 46.15 138.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46587 461
FHH-Chr 15BN/Mcwi serum glucose level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 145.13 mg/dl 11.21 31.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38569 401
FHH-Chr 15BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 54.09 fl 0.33 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38648 401
FHH-Chr 15BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 42.7 % 1.05 2.96 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57469 526
FHH-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.51 null 0.05 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55267 522
FHH-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.31 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57883 526
FHH-Chr 15BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 157.7 g 3.2 10.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55409 522
FHH-Chr 15BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.61 g/mg 0.08 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55761 522
FHH-Chr 15BN/Mcwi body temperature air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.18 degrees C 0.19 0.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16612 381
FHH-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.41 null 0.06 0.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58141 526
FHH-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.03 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54647 522
FHH-Chr 15BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.03 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54666 522
FHH-Chr 15BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 0.93 E-7mole 0.13 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56512 522
FHH-Chr 15BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.41 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17398 381
FHH-Chr 15BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 5.33 g/kg 0.12 0.39 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46964 461
FHH-Chr 15BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 8.3 g/kg 0.39 1.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45608 461
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 43.68 mmHg 8.88 21.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47740 461
FHH-Chr 15BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 10 115.8 g 5.8 18.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47805 461
FHH-Chr 15BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 48.53 % 8.18 20.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47116 461
FHH-Chr 15BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 82.5 % 4.89 12.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48445 461
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.32 mmHg 0.37 1.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49205 461
FHH-Chr 15BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 3.63 x 1000 cells/ul 0.21 0.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36851 401
FHH-Chr 15BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 7 2.4 ml/min 0.46 1.23 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52361 482
FHH-Chr 15BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.39 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17410 381
FHH-Chr 15BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 21.77 mmHg 5.17 12.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47950 461
FHH-Chr 15BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 97.38 mg/dl 3.33 9.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38415 401
FHH-Chr 15BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 36.81 degrees C 0.36 1.12 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16840 381
FHH-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 69.88 % 5.93 16.78 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57197 522
FHH-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 6.81 % 1.36 3.84 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49424 461
FHH-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 86.44 % 3.85 11.54 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54772 522
FHH-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 7 4.81 % 1.32 3.49 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49737 461
FHH-Chr 15BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 13.65 g/dl 0.33 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40084 401
FHH-Chr 15BN/Mcwi heart weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 6.29 g/kg 0.36 1.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45589 461
FHH-Chr 15BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.63 g 0.06 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45433 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 93.18 mmHg 7.93 22.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45543 461
FHH-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.54 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58761 526
FHH-Chr 15BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 1006.11 s 33.17 99.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50158 461
FHH-Chr 15BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 65.13 U/l 1.84 5.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37689 401
FHH-Chr 15BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.81 x 1000 cells/ul 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38878 401
FHH-Chr 15BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.44 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38897 401
FHH-Chr 15BN/Mcwi blood hemoglobin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 17.49 g/dl 0.25 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37996 401
FHH-Chr 15BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 131.63 % 7.88 23.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54125 381
FHH-Chr 15BN/Mcwi percent change in tidal volume air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 99.58 % 5.2 16.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54015 381
FHH-Chr 15BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 107.83 breaths/min 4.01 12.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18438 381
FHH-Chr 15BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 99.91 breaths/min 3.38 10.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14963 381
FHH-Chr 15BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.3 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18010 381
FHH-Chr 15BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.31 ml 0.04 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18022 381
FHH-Chr 15BN/Mcwi respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 136.23 breaths/min 7.16 22.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18293 381
FHH-Chr 15BN/Mcwi minute ventilation air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 38.87 ml/min 2.95 9.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20236 381
FHH-Chr 15BN/Mcwi time to onset of heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 928.88 s 27.06 76.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49327 461
FHH-Chr 15BN/Mcwi time to peak heart contraction air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1302.75 s 39.98 113.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50266 461
FHH-Chr 15BN/Mcwi serum albumin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.33 g/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42261 401
FHH-Chr 15BN/Mcwi serum bicarbonate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 21.5 mmol/l 0.78 2.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42101 401
FHH-Chr 15BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 15.88 mmol/l 0.4 1.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43132 401
FHH-Chr 15BN/Mcwi percent change in respiration rate air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 142.56 % 10.31 30.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54366 381
FHH-Chr 15BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 141.82 % 10.13 30.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54465 381
FHH-Chr 15BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.8 g/dl 0.03 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40389 401
FHH-Chr 15BN/Mcwi body weight air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 13 104.2 g 3.9 14.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59101 526
FHH-Chr 15BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.08 mmol/l 0.12 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43309 401
FHH-Chr 15BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.17 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40276 401
FHH-Chr 15BN/Mcwi hematocrit air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 54.14 % 1.65 4.65 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59296 526
FHH-Chr 15BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.36 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40589 401
FHH-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59359 526
FHH-Chr 15BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 0.92 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59436 526
FHH-Chr 15BN/Mcwi serum phosphate level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 11.04 mg/dl 0.51 1.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37633 401
FHH-Chr 15BN/Mcwi serum alanine aminotransferase activity level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 75.88 U/l 7.18 20.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40753 401
FHH-Chr 15BN/Mcwi serum potassium level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 5.16 mmol/l 0.31 0.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38094 401
FHH-Chr 15BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 13 1.8 g/kg 0.04 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59696 526
FHH-Chr 15BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.24 g/dl 0.02 0.05 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41028 401
FHH-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.37 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59774 526
FHH-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59575 526
FHH-Chr 15BN/Mcwi lung dry weight to body weight ratio air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.64 g/kg 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59685 526
FHH-Chr 15BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.11 x 10E6 cells/ul 0.19 0.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41951 401
FHH-Chr 15BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.58 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55248 522
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 23.68 ml/min/kg 2.79 7.89 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57828 526
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 23.66 ml/min/kg 1.75 5.24 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57839 526
FHH-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.28 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57902 526
FHH-Chr 15BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.36 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16513 381
FHH-Chr 15BN/Mcwi percent change in arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 45.08 % 2.81 7.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47105 461
FHH-Chr 15BN/Mcwi heart rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 159.95 beats/min 16.39 46.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45176 461
FHH-Chr 15BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 213.79 beats/min 20.9 62.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48236 461
FHH-Chr 15BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 194.06 beats/min 9.15 24.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48984 461
FHH-Chr 15BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 54.8 ml/min 3.28 9.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20801 381
FHH-Chr 15BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 9 171.0 g 2.6 7.8 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17857 381
FHH-Chr 15BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 155.67 breaths/min 9.87 29.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16951 381
FHH-Chr 15BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 198.81 % 20.32 60.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14238 381
FHH-Chr 15BN/Mcwi serum total protein level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.69 g/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37001 401
FHH-Chr 15BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.2 g/dl 0.05 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37180 401
FHH-Chr 15BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.57 mg/dl 0.16 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36741 401
FHH-Chr 15BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.41 mg/dl 0.07 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36760 401
FHH-Chr 15BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 36.68 mg/d 12.67 33.51 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52408 482
FHH-Chr 15BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 7 1.1 mEq/d 0.16 0.43 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52314 482
FHH-Chr 15BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 28.17 mmHg 5.21 11.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45309 461
FHH-Chr 15BN/Mcwi arterial blood flow rate air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 6.29 ml/min/g 1.13 3.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44746 461
FHH-Chr 15BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 29.63 mmHg 2.64 7.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48061 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 16.71 IU/g 2.7 7.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45950 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 8.43 ml/min/g 0.88 2.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46898 461
FHH-Chr 15BN/Mcwi serum total bilirubin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.13 mg/dl 0.02 0.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41896 401
FHH-Chr 15BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 6 77.67 % 5.9 14.46 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54753 522
FHH-Chr 15BN/Mcwi heart wet weight air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.75 g 0.06 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45444 461
FHH-Chr 15BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1210.25 s 43.42 122.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46576 461
FHH-Chr 15BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 159.43 % 18.7 56.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53674 381
FHH-Chr 15BN/Mcwi left ventricular developed pressure air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 95.93 mmHg 8.89 23.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48663 461
FHH-Chr 15BN/Mcwi serum globulin level air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.36 g/dl 0.05 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40578 401
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 14.68 IU/g 1.63 4.62 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48839 461
FHH-Chr 15BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.4 g/dl 0.02 0.05 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41009 401
FHH-Chr 15BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 29.06 ml/min 2.46 7.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16187 381
FHH-Chr 15BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.62 g/mg 0.07 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57307 522
FHH-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.38 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59755 526
FHH-Chr 15BN/Mcwi FAPGG metabolism-surface area product air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 69.53 ml/min/kg 2.37 7.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58038 526