Phenominer Database Results (406 results)

 

How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 11BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 4 141.62 breaths/min 9.8 19.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17186 381
FHH-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 5 25.85 mmHg 2.25 5.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17277 381
FHH-Chr 11BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17085 381
FHH-Chr 11BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 54.86 ml/min 6.04 15.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20835 381
FHH-Chr 11BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 379.42 beats/min 20.52 54.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20958 381
FHH-Chr 11BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19821 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 50.43 mmHg 33.41 74.71 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19897 381
FHH-Chr 11BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 4 143.13 breaths/min 14.41 28.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16986 381
FHH-Chr 11BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 421.67 U/l 17.79 53.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36452 401
FHH-Chr 11BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 4.74 g/dl 0.12 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37036 401
FHH-Chr 11BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 3 466.66 beats/min 34.17 59.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15963 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 3 136.44 mmHg 15.4 26.68 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15125 381
FHH-Chr 11BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 4 18.03 mEq/d 2.64 5.28 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52814 482
FHH-Chr 11BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 678.48 beats/min 167.28 374.05 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14729 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 47.44 mmHg 31.78 71.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13516 381
FHH-Chr 11BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 7.44 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20660 381
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 771.68 beats/min 175.59 430.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17536 381
FHH-Chr 11BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.84 mg/dl 0.07 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36817 401
FHH-Chr 11BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 203.05 beats/min 9.77 27.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49018 461
FHH-Chr 11BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 -38.3 mmHg 2.1 2.97 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19496 381
FHH-Chr 11BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.6 g/dl 0.09 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42307 401
FHH-Chr 11BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 22.0 mmol/l 0.83 2.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42136 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.76 pg 0.12 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42619 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.74 g/dl 0.14 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39851 401
FHH-Chr 11BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 4 122.01 % 17.26 34.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54498 381
FHH-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 136.18 % 13.06 36.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54399 381
FHH-Chr 11BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.34 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39650 401
FHH-Chr 11BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.13 x 1000 cells/ul 0.05 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40352 401
FHH-Chr 11BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 4 140.28 % 5.41 10.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53708 381
FHH-Chr 11BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.9 g/dl 0.03 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40470 401
FHH-Chr 11BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 61.22 U/l 7.57 22.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40787 401
FHH-Chr 11BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 5.57 x 1000 cells/ul 0.56 1.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40999 401
FHH-Chr 11BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.1 x 1000 cells/ul 0.71 2.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41000 401
FHH-Chr 11BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 11.74 mg/dl 1.05 3.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37668 401
FHH-Chr 11BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 9.19 mg/dl 0.25 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37890 401
FHH-Chr 11BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.66 g/dl 0.39 1.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38041 401
FHH-Chr 11BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.62 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59730 526
FHH-Chr 11BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 46.75 U/l 5.22 14.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37770 401
FHH-Chr 11BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 14.5 mg/dl 0.8 2.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41810 401
FHH-Chr 11BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.26 x 1000 cells/ul 0.62 1.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41577 401
FHH-Chr 11BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 88.88 mg/dl 2.5 7.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38496 401
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.32 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47497 461
FHH-Chr 11BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.99 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45477 461
FHH-Chr 11BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.82 g 0.06 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45478 461
FHH-Chr 11BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 223.6 mg/dl 40.31 127.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38604 401
FHH-Chr 11BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 190.0 g 3.7 11.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55231 522
FHH-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.79 null 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55329 522
FHH-Chr 11BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 42.7 % 0.66 1.88 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57550 526
FHH-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 32.5 mmHg 2.8 3.96 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16100 381
FHH-Chr 11BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 0.44 ml 0.05 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16548 381
FHH-Chr 11BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.07 degrees C 0.29 0.87 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16887 381
FHH-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 0.64 E-7mole 0.11 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55943 522
FHH-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 0.77 E-7mole 0.18 0.56 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55948 522
FHH-Chr 11BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 68.92 ml/min/kg 7.35 20.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58072 526
FHH-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -8.19 null 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56152 522
FHH-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.66 E-7mole 0.28 0.85 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56567 522
FHH-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.52 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58806 526
FHH-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.53 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58807 526
FHH-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59946 526
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 10.94 ml/min/kg 0.85 2.41 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60052 526
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 9.92 ml/min/g 0.65 1.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46726 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 77.37 mmHg 5.37 17.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46823 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.48 ml/min/g 0.61 1.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46942 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 8.3 ml/min/g 0.6 1.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46943 461
FHH-Chr 11BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 5.47 g/kg 0.13 0.41 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47045 461
FHH-Chr 11BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 39.6 mmHg 2.55 8.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48107 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 88.93 mmHg 8.94 25.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44888 461
FHH-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 51.91 % 5.07 14.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46138 461
FHH-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 29.49 % 1.6 5.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47149 461
FHH-Chr 11BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 79.53 % 5.12 16.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48480 461
FHH-Chr 11BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 744.72 beats/min 191.06 467.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20954 381
FHH-Chr 11BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 0.82 g 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49134 461
FHH-Chr 11BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.35 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18056 381
FHH-Chr 11BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 127.89 % 10.13 30.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13755 381
FHH-Chr 11BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 5 502.92 mg/d 120.49 269.42 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52128 482
FHH-Chr 11BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 5 176.89 mmHg 12.96 28.98 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52567 482
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 149.2 beats/min 30.4 67.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45221 461
FHH-Chr 11BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 7.31 g/kg 0.26 0.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45665 461
FHH-Chr 11BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.0 g/kg 0.27 0.85 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45670 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 58.66 mmHg 7.59 21.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47774 461
FHH-Chr 11BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42709 401
FHH-Chr 11BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -7.19 null 0.08 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55679 522
FHH-Chr 11BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.42 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16547 381
FHH-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 119.65 % 8.99 26.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54400 381
FHH-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 75.22 % 6.93 20.79 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54827 522
FHH-Chr 11BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 958.4 s 40.53 128.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50193 461
FHH-Chr 11BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1200.8 s 29.93 94.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50299 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 83.11 mmHg 5.37 16.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45577 461
FHH-Chr 11BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 58.24 fl 0.31 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38818 401
FHH-Chr 11BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.49 g/dl 0.05 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41090 401
FHH-Chr 11BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.85 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59731 526
FHH-Chr 11BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 103.38 U/l 6.42 18.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42475 401
FHH-Chr 11BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 42.7 % 0.66 1.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41365 401
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 27.06 ml/min/kg 1.15 3.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57873 526
FHH-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 104.6 % 7.54 22.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54060 381
FHH-Chr 11BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 137.71 % 11.94 31.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54158 381
FHH-Chr 11BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 0.05 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19817 381
FHH-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 109.04 % 5.14 15.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53827 381
FHH-Chr 11BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 4.81 g/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37035 401
FHH-Chr 11BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 55.78 mg/dl 4.56 13.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37170 401
FHH-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.34 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15308 381
FHH-Chr 11BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 4 -0.75 degrees C 0.53 1.06 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15743 381
FHH-Chr 11BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 4 431.62 beats/min 7.42 14.85 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52518 482
FHH-Chr 11BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 3 1.02 ng/ml/h 0.4 0.69 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52912 482
FHH-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.4 mg/dl 0.07 0.16 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52279 482
FHH-Chr 11BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 4 1.27 mEq/d 0.18 0.35 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52326 482
FHH-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 %change=VE during7-9 min hypercapnia/control during standard conditions 181.13 % 19.99 52.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14272 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 61.26 mmHg 34.35 84.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14363 381
FHH-Chr 11BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 4 36.55 degrees C 0.1 0.21 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13634 381
FHH-Chr 11BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 9 185.8 g 6.7 20.2 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17892 381
FHH-Chr 11BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 7.45 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20656 381
FHH-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during7-9 min hypercapnia/control during standard conditions 123.55 % 8.32 23.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18617 381
FHH-Chr 11BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.76 mg/dl 0.08 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36822 401
FHH-Chr 11BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.39 g/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37261 401
FHH-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 %change=VE during 2-3 min hypercapnia/control during standard conditions 204.29 % 21.84 43.69 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19286 381
FHH-Chr 11BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 5 -48.66 mmHg 3.86 8.62 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19500 381
FHH-Chr 11BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 987.8 s 20.58 65.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50192 461
FHH-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 7.22 % 1.5 4.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49469 461
FHH-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 117.2 g 7.8 24.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49572 461
FHH-Chr 11BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.39 x 1000 cells/ul 0.04 0.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38959 401
FHH-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 51.41 % 1.33 4.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39065 401
FHH-Chr 11BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 140.1 mmol/l 0.55 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39462 401
FHH-Chr 11BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 82.8 U/l 6.51 20.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42844 401
FHH-Chr 11BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42941 401
FHH-Chr 11BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 101.75 mmol/l 0.73 2.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40064 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 31.78 g/dl 0.23 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39850 401
FHH-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 51.41 % 1.33 4.22 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59331 526
FHH-Chr 11BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 22.7 mg/dl 1.22 3.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40902 401
FHH-Chr 11BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 0.93 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59512 526
FHH-Chr 11BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.11 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59517 526
FHH-Chr 11BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.65 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41085 401
FHH-Chr 11BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 4.76 mmol/l 0.26 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38139 401
FHH-Chr 11BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41462 401
FHH-Chr 11BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1157.8 s 40.43 127.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46622 461
FHH-Chr 11BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 30.71 ml/min 2.66 7.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16221 381
FHH-Chr 11BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 32.24 ml/min 6.94 13.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16222 381
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 18.14 ml/min/kg 1.58 3.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57672 526
FHH-Chr 11BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 36.22 degrees C 0.47 1.05 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16646 381
FHH-Chr 11BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.27 degrees C 0.4 1.21 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16647 381
FHH-Chr 11BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.89 g/mg 0.12 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55837 522
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 18.96 ml/min/kg 1.52 4.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58681 526
FHH-Chr 11BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.84 null 0.11 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56967 522
FHH-Chr 11BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.4 ml 0.04 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17444 381
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 3.78 ml/min/g 0.3 0.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44791 461
FHH-Chr 11BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 84.77 % 5.59 15.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48479 461
FHH-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 107.29 % 4.83 14.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53959 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 132.9 mmHg 8.84 23.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15129 381
FHH-Chr 11BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 139.63 % 12.11 32.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54292 381
FHH-Chr 11BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 5 107.99 mmHg 4.73 10.58 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18904 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 3 112.8 mmHg 7.1 12.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13520 381
FHH-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 48.74 ml/min 4.02 11.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18736 381
FHH-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 118.2 breaths/min 3.15 9.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14869 381
FHH-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 6 70.1 mg/d 24.53 60.08 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52422 482
FHH-Chr 11BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 5 419.76 beats/min 9.0 20.13 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52520 482
FHH-Chr 11BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 239.43 beats/min 7.17 22.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48270 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.49 ml/min/g 0.22 0.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46725 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 85.48 mmHg 7.39 23.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46824 461
FHH-Chr 11BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.35 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39747 401
FHH-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 7.45 % 1.21 3.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49470 461
FHH-Chr 11BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 164.22 mg/dl 9.42 28.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38603 401
FHH-Chr 11BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 6 900.17 s 42.53 104.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49372 461
FHH-Chr 11BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 6 33.83 mmHg 3.44 8.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50070 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 113.02 mmHg 4.9 12.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48697 461
FHH-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54958 522
FHH-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 23.9 % 2.94 9.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48599 461
FHH-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 55.89 % 1.6 4.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39064 401
FHH-Chr 11BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 24.33 mg/dl 1.26 3.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40901 401
FHH-Chr 11BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 107.5 mmol/l 0.58 1.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39191 401
FHH-Chr 11BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 3 399.38 beats/min 36.3 62.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14733 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 3 116.32 mmHg 10.58 18.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19901 381
FHH-Chr 11BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 60.1 ml/min 7.73 15.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20836 381
FHH-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 45.97 ml/min 3.37 10.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18737 381
FHH-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 129.92 breaths/min 8.01 24.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18340 381
FHH-Chr 11BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 94.55 mmHg 4.85 6.86 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18900 381
FHH-Chr 11BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.3 ml 0.01 0.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15471 381
FHH-Chr 11BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 0.31 ml 0.03 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15472 381
FHH-Chr 11BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 6 10.12 mEq/d 2.33 5.71 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52816 482
FHH-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 3 0.31 mg/dl 0.05 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52277 482
FHH-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.37 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13997 381
FHH-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.36 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13998 381
FHH-Chr 11BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 4 37.58 degrees C 0.26 0.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19143 381
FHH-Chr 11BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 5 59.33 mmHg 1.44 3.21 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20512 381
FHH-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 3.92 % 1.46 4.39 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49771 461
FHH-Chr 11BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 1162.83 s 30.3 74.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50300 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.74 mmHg 0.19 0.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49250 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.3 mmHg 0.32 1.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49251 461
FHH-Chr 11BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 969.9 s 25.92 81.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49371 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 87.95 mmHg 6.03 19.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49960 461
FHH-Chr 11BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 22.11 mmol/l 1.14 3.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42135 401
FHH-Chr 11BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 59.11 fl 0.47 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38819 401
FHH-Chr 11BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 9.55 x 10E6 cells/ul 0.24 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39310 401
FHH-Chr 11BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 90.33 U/l 5.65 16.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42843 401
FHH-Chr 11BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42704 401
FHH-Chr 11BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42946 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.93 pg 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40256 401
FHH-Chr 11BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.34 mmol/l 0.19 0.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43385 401
FHH-Chr 11BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 13.63 g/dl 0.18 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40165 401
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.2 mg/kg 0.44 1.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58979 526
FHH-Chr 11BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 42.5 U/l 3.05 9.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40788 401
FHH-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.04 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59416 526
FHH-Chr 11BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 44.55 % 0.52 1.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41360 401
FHH-Chr 11BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 88.5 mg/dl 2.66 7.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38491 401
FHH-Chr 11BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.14 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41942 401
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 244.32 beats/min 6.26 17.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47655 461
FHH-Chr 11BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 55.35 fl 0.26 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38710 401
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 17.94 ml/min/kg 0.65 1.83 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57671 526
FHH-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 -7.76 null 0.14 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55324 522
FHH-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 92.14 % 4.86 12.86 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57273 522
FHH-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 81.6 % 5.03 15.9 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57278 522
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 28.05 ml/min/kg 2.08 5.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57874 526
FHH-Chr 11BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 44.51 ml/min/kg 11.94 33.76 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58284 526
FHH-Chr 11BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 41.53 ml/min/kg 8.6 22.74 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58289 526
FHH-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58563 526
FHH-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.68 E-7mole 0.4 1.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56572 522
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 14.02 ml/min/kg 1.33 3.51 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60057 526
FHH-Chr 11BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 5.37 g/kg 0.18 0.57 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47040 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 54.89 mmHg 3.55 11.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47775 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 124.4 mmHg 5.33 16.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45801 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 34.27 mmHg 4.95 13.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47984 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 4.34 ml/min/g 0.54 1.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46274 461
FHH-Chr 11BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 230.33 beats/min 10.8 34.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48271 461
FHH-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 45.04 % 4.14 13.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46393 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 5.36 mmHg 0.15 0.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47270 461
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 153.29 beats/min 9.05 27.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45220 461
FHH-Chr 11BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 144.57 % 9.93 19.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54159 381
FHH-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.37 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15307 381
FHH-Chr 11BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 136.25 breaths/min 3.24 8.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17185 381
FHH-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 2 25.25 mmHg 3.6 5.09 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17273 381
FHH-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 135.94 breaths/min 13.24 37.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18339 381
FHH-Chr 11BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 9.24 mg/dl 0.23 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36697 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 31.94 g/dl 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37386 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.94 g/dl 0.16 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37391 401
FHH-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 112.98 % 8.11 24.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18618 381
FHH-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 %change=VE during 2-3 min hypercapnia/control during standard conditions 211.9 % 28.22 74.65 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19285 381
FHH-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 38.74 % 3.13 6.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47150 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 4.41 ml/min/g 0.22 0.69 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46275 461
FHH-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 40.9 % 6.59 18.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46392 461
FHH-Chr 11BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 60.37 % 12.88 28.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48368 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 118.38 mmHg 5.0 12.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45802 461
FHH-Chr 11BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 172.2 g 5.2 16.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47862 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 92.29 mmHg 4.65 14.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44889 461
FHH-Chr 11BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 3.79 x 1000 cells/ul 0.34 0.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39948 401
FHH-Chr 11BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 29.38 mmol/l 1.35 3.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43053 401
FHH-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 8.16 % 1.63 5.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49770 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 86.38 mmHg 2.82 6.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49961 461
FHH-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54953 522
FHH-Chr 11BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1156.3 s 20.5 64.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46621 461
FHH-Chr 11BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 223.5 U/l 10.14 28.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37513 401
FHH-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 73.6 % 3.9 9.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48829 461
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.2 mg/kg 0.37 0.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58980 526
FHH-Chr 11BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.67 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42306 401
FHH-Chr 11BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 53.38 U/l 2.8 7.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37765 401
FHH-Chr 11BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 16.31 g/dl 0.45 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38042 401
FHH-Chr 11BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 102.38 U/l 3.28 9.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42480 401
FHH-Chr 11BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 4 188.98 mmHg 4.83 9.66 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52565 482
FHH-Chr 11BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17081 381
FHH-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 118.72 % 5.88 16.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53826 381
FHH-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 104.27 % 6.25 17.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53958 381
FHH-Chr 11BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 101.29 breaths/min 6.78 19.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18484 381
FHH-Chr 11BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 110.37 breaths/min 6.04 18.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18485 381
FHH-Chr 11BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 151.34 breaths/min 8.59 22.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16985 381
FHH-Chr 11BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 275.88 U/l 7.88 22.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36453 401
FHH-Chr 11BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.28 x 1000 cells/ul 0.31 0.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36932 401
FHH-Chr 11BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 65.19 ml/min 9.97 26.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14574 381
FHH-Chr 11BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 4 -0.45 degrees C 0.43 0.87 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15744 381
FHH-Chr 11BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 101.79 breaths/min 8.32 22.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15009 381
FHH-Chr 11BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.34 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18057 381
FHH-Chr 11BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 -7.25 mmHg 6.4 9.05 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19665 381
FHH-Chr 11BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 5 -6.33 mmHg 0.5 1.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19669 381
FHH-Chr 11BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.8 degrees C 0.29 0.87 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20384 381
FHH-Chr 11BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 36.3 mmHg 3.04 9.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50069 461
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 18.51 pg 0.12 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42618 401
FHH-Chr 11BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 108.33 mmol/l 0.69 2.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39190 401
FHH-Chr 11BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.7 x 10E6 cells/ul 0.27 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39311 401
FHH-Chr 11BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 4.81 x 1000 cells/ul 0.28 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39943 401
FHH-Chr 11BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 29.0 mmol/l 0.78 2.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43048 401
FHH-Chr 11BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 16.25 mmol/l 1.05 2.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43189 401
FHH-Chr 11BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 0.64 x 1000 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43297 401
FHH-Chr 11BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.57 x 1000 cells/ul 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43298 401
FHH-Chr 11BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.99 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40465 401
FHH-Chr 11BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.0 mmol/l 0.2 0.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43390 401
FHH-Chr 11BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 102.38 mmol/l 1.0 2.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40069 401
FHH-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 55.89 % 1.6 4.81 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59330 526
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.38 mg/kg 0.16 0.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59222 526
FHH-Chr 11BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 10.18 mg/dl 0.19 0.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37667 401
FHH-Chr 11BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 144.71 mg/dl 3.29 8.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41252 401
FHH-Chr 11BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 143.25 mg/dl 3.98 11.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41257 401
FHH-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.2 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59621 526
FHH-Chr 11BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.99 mmol/l 0.26 0.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38140 401
FHH-Chr 11BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 16.44 mmol/l 1.31 3.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38334 401
FHH-Chr 11BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 17.13 mg/dl 0.97 2.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41815 401
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 118.82 mmHg 5.22 16.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48696 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 61.33 mmHg 3.94 12.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46489 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 54.86 mmHg 4.05 9.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46490 461
FHH-Chr 11BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.41 x 10E6 cells/ul 0.12 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42027 401
FHH-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 5 32.18 mmHg 2.58 5.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16104 381
FHH-Chr 11BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.74 g/mg 0.1 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57381 522
FHH-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 70.34 % 3.38 10.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48828 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 18.55 IU/g 1.08 3.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48903 461
FHH-Chr 11BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 44.55 % 0.52 1.46 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57545 526
FHH-Chr 11BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 249.1 g 6.8 21.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58396 526
FHH-Chr 11BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 187.3 g 4.9 15.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58401 526
FHH-Chr 11BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 62.9 ml/min/kg 9.82 25.97 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58073 526
FHH-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.42 null 0.04 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58186 526
FHH-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -8.2 null 0.11 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56157 522
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 22.09 ml/min/kg 2.39 6.31 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58686 526
FHH-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.56 null 0.1 0.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59830 526
FHH-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.76 null 0.23 0.6 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59835 526
FHH-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.12 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59951 526
FHH-Chr 11BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -6.85 null 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56962 522
FHH-Chr 11BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 0.42 ml 0.04 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17445 381
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 11.3 IU/g 1.12 3.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46001 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 12.22 IU/g 1.74 4.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46005 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.58 mmHg 0.23 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47269 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.35 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47360 461
FHH-Chr 11BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 67.89 % 4.91 14.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48367 461
FHH-Chr 11BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 181.23 beats/min 11.51 36.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49019 461
FHH-Chr 11BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 4 37.0 degrees C 0.36 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19144 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 126.72 mmHg 7.24 19.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14367 381
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 381.44 beats/min 11.69 30.92 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17540 381
FHH-Chr 11BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 6 0.62 mEq/d 0.16 0.4 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52328 482
FHH-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 104.98 % 6.18 19.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44992 461
FHH-Chr 11BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 39.8 mmHg 3.23 10.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48106 461
FHH-Chr 11BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41467 401
FHH-Chr 11BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 35.73 ml/min 2.81 7.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16764 381
FHH-Chr 11BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 5 37.18 degrees C 0.23 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16886 381
FHH-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 136.0 g 5.1 16.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49567 461
FHH-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 7 0.02 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54723 522
FHH-Chr 11BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 1.14 g/dl 0.06 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40623 401
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 230.78 beats/min 7.28 23.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47654 461
FHH-Chr 11BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.1 x 1000 cells/ul 0.03 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40357 401
FHH-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 166.0 g 4.8 15.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59135 526
FHH-Chr 11BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.76 g/mg 0.16 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57386 522
FHH-Chr 11BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 242.7 g 8.3 26.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55463 522
FHH-Chr 11BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 185.6 g 3.5 11.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55468 522
FHH-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.28 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57964 526
FHH-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 119.06 breaths/min 6.9 19.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14868 381
FHH-Chr 11BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 6 222.69 mg/d 61.15 149.78 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52130 482
FHH-Chr 11BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 3 1.71 ml/min 0.15 0.27 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52373 482
FHH-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 5 131.21 mg/d 42.63 95.32 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52420 482
FHH-Chr 11BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 5.01 ng/ml/h 2.7 6.04 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52914 482
FHH-Chr 11BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 4 36.83 degrees C 0.38 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13633 381
FHH-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 %change=VE during7-9 min hypercapnia/control during standard conditions 200.83 % 33.54 67.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14273 381
FHH-Chr 11BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 4 103.4 breaths/min 13.56 27.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15010 381
FHH-Chr 11BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 63.02 ml/min 10.0 19.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14575 381
FHH-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 104.54 % 6.16 17.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54059 381
FHH-Chr 11BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 4 141.59 % 14.72 29.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54293 381
FHH-Chr 11BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 139.68 % 12.64 35.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13754 381
FHH-Chr 11BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 8 220.6 g 13.8 38.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17891 381
FHH-Chr 11BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 59.0 mg/dl 2.49 7.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37171 401
FHH-Chr 11BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.64 g/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37256 401
FHH-Chr 11BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.44 mg/dl 0.14 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36698 401
FHH-Chr 11BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 141.88 mmol/l 0.61 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36553 401
FHH-Chr 11BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.93 g 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49133 461
FHH-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 40.76 ml/min 3.34 10.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20283 381
FHH-Chr 11BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 56.25 mmHg 2.75 3.89 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20508 381
FHH-Chr 11BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.6 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38954 401
FHH-Chr 11BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 142.0 mmol/l 0.73 2.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39461 401
FHH-Chr 11BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.25 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39748 401
FHH-Chr 11BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 4 139.52 % 10.49 20.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54499 381
FHH-Chr 11BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 14.25 mmol/l 1.18 3.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43194 401
FHH-Chr 11BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.32 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39649 401
FHH-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 160.0 g 5.5 17.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59136 526
FHH-Chr 11BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.14 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40624 401
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 1.87 mg/kg 0.42 1.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59227 526
FHH-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59421 526
FHH-Chr 11BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.38 mg/dl 0.36 1.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37885 401
FHH-Chr 11BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41721 401
FHH-Chr 11BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.12 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41941 401
FHH-Chr 11BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 7.71 x 10E6 cells/ul 0.11 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42032 401
FHH-Chr 11BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 52.99 fl 0.29 0.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38705 401
FHH-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 27.9 % 5.1 12.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48600 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 90.77 mmHg 7.32 23.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45578 461
FHH-Chr 11BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 257.6 g 8.2 25.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55226 522
FHH-Chr 11BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 7 -7.22 null 0.06 0.15 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55674 522
FHH-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.28 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57959 526
FHH-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.47 null 0.09 0.21 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58187 526
FHH-Chr 11BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 36.83 ml/min 3.05 9.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16765 381
FHH-Chr 11BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 1.47 g/mg 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55842 522
FHH-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 70.22 % 6.78 20.35 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54832 522
FHH-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54728 522
FHH-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58562 526
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 37.4 mmHg 3.27 10.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47985 461
FHH-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 113.76 % 9.27 26.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44991 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.43 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47356 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 3.1 ml/min/g 0.18 0.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44790 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 31.52 mmHg 6.15 15.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45343 461
FHH-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 45.06 ml/min 5.78 16.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20282 381
FHH-Chr 11BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 -0.96 degrees C 0.65 1.44 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20383 381
FHH-Chr 11BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.08 x 1000 cells/ul 0.32 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36927 401
FHH-Chr 11BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 742.73 beats/min 162.02 362.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15959 381
FHH-Chr 11BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.25 mmol/l 0.84 2.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36548 401
FHH-Chr 11BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 5 1.06 ml/min 0.21 0.48 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52375 482
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 26.62 mmHg 4.1 12.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45342 461
FHH-Chr 11BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 10 149.8 g 2.8 8.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47867 461
FHH-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 55.35 % 4.42 13.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46139 461
FHH-Chr 11BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 4.52 x 1000 cells/ul 0.43 1.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41576 401
FHH-Chr 11BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 15.6 mmol/l 1.08 3.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38335 401
FHH-Chr 11BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.06 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41720 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.68 pg 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40261 401
FHH-Chr 11BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 153.55 % 12.21 32.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53707 381
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.36 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47492 461
FHH-Chr 11BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 14.23 g/dl 0.17 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40160 401
FHH-Chr 11BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 332.0 U/l 11.92 33.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37508 401
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 23.38 IU/g 2.68 7.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48900 461
FHH-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.17 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59620 526