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Strain |
Phenotype |
Conditions |
Study |
Experiment Name |
Sex |
Age |
# of Animals |
Value |
Units |
SEM |
SD |
Method |
Method Duration |
Post Insult Time Value |
Clinical Measurement Notes |
Record ID |
Study ID |
Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
AMG-8718 (600 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81 days-88 days |
5 |
10.5 |
null |
0.42 |
0.95 |
ex vivo light microscopy with histochemistry |
0.0 |
0 |
nuclei per cell |
105453 |
3016 |
Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81 days-88 days |
5 |
11.3 |
null |
0.37 |
0.83 |
ex vivo light microscopy with histochemistry |
0.0 |
0 |
nuclei per cell |
105450 |
3016 |
Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
vehicle control condition (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137 days-144 days |
5 |
10.5 |
null |
0.4 |
0.9 |
ex vivo light microscopy with histochemistry |
0.0 |
0 |
nuclei per cell |
105462 |
3016 |
Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
AMG-8718 (100 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137 days-144 days |
5 |
10.1 |
null |
0.4 |
0.9 |
ex vivo light microscopy with histochemistry |
0.0 |
0 |
nuclei per cell |
105464 |
3016 |
Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
AMG-8718 (10 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137 days-144 days |
5 |
10.7 |
null |
0.4 |
0.9 |
ex vivo light microscopy with histochemistry |
0.0 |
0 |
nuclei per cell |
105463 |
3016 |
Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
AMG-8718 (10 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81 days-88 days |
5 |
11.3 |
null |
0.32 |
0.72 |
ex vivo light microscopy with histochemistry |
0.0 |
0 |
nuclei per cell |
105451 |
3016 |
Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
AMG-8718 (100 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81 days-88 days |
5 |
11.7 |
null |
0.31 |
0.7 |
ex vivo light microscopy with histochemistry |
0.0 |
0 |
nuclei per cell |
105452 |
3016 |
Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
AMG-8718 (600 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137 days-144 days |
5 |
8.4 |
null |
0.49 |
1.1 |
ex vivo light microscopy with histochemistry |
0.0 |
0 |
nuclei per cell |
105465 |
3016 |
|