SHR |
diastolic blood pressure |
controlled sodium content drinking water (1 %) (for 15 days) |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
arterial blood pressure trait |
male |
99.0 days
| 24 |
continuous mean |
144.0 |
mmHg |
2.0 |
9.8 |
vascular indwelling catheter method |
femoral artery |
1800 |
0 |
|
pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) |
|
65349 |
306 |
SHR |
diastolic blood pressure |
control condition |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
arterial blood pressure trait |
male |
99.0 days
| 23 |
continuous mean |
138.0 |
mmHg |
2.0 |
9.59 |
vascular indwelling catheter method |
femoral artery |
1800 |
0 |
|
pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) |
|
65351 |
306 |
SHR |
mean arterial blood pressure |
control condition |
Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 |
arterial blood pressure trait |
male |
112.0 days
| 28 |
continuous mean |
195.7 |
mmHg |
2.48 |
13.1 |
tail cuff plethysmography |
|
0 |
0 |
|
animals were prewarmed to 34 degrees C for 20 min before BP |
|
65082 |
206 |
SHR |
mean arterial blood pressure |
control condition |
Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 |
arterial blood pressure trait |
male |
140.0 days
| 28 |
continuous mean |
206.8 |
mmHg |
2.36 |
12.5 |
tail cuff plethysmography |
|
|
0 |
|
animals were prewarmed to 34 degrees C for 20 min before BP |
|
65086 |
206 |
SHR |
systolic blood pressure |
control condition |
Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 |
arterial blood pressure trait |
male |
175.0 days
| 28 |
continuous mean |
232.2 |
mmHg |
2.29 |
12.1 |
vascular indwelling catheter method |
aorta |
|
0 |
|
|
|
11903 |
206 |
SHR |
body weight |
controlled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days) |
Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. |
body mass |
female |
360.0 days
| 4 |
|
173.5 |
g |
2.3 |
4.6 |
body weighing method |
|
0 |
0 |
|
|
|
12575 |
268 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
11.95 |
gx10 |
0.91 |
2.41 |
Randall-Selitto test |
|
|
120 |
min |
0.1% methylcellulose per os |
|
108223 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
10.99 |
gx10 |
0.89 |
2.36 |
Randall-Selitto test |
|
|
150 |
min |
0.1% methylcellulose per os |
|
108225 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
proestrus then diclofenac (40 mg/kg) (for 0.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
10.08 |
gx10 |
0.91 |
2.41 |
Randall-Selitto test |
|
|
30 |
min |
0.1% methylcellulose per os |
|
108230 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
proestrus then diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
12.69 |
gx10 |
0.96 |
2.54 |
Randall-Selitto test |
|
|
90 |
min |
0.1% methylcellulose per os |
|
108234 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
control condition |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
10.35 |
gx10 |
0.96 |
2.53 |
Randall-Selitto test |
|
0.0 |
0 |
|
|
|
108216 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
13.23 |
gx10 |
1.01 |
2.68 |
Randall-Selitto test |
|
|
90 |
min |
0.1% methylcellulose per os |
|
108221 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
estrus then diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
11.37 |
gx10 |
0.86 |
2.27 |
Randall-Selitto test |
|
|
90 |
min |
0.1% methylcellulose per os |
|
108248 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
estrus then diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.94 |
gx10 |
0.54 |
1.44 |
Randall-Selitto test |
|
|
150 |
min |
0.1% methylcellulose per os |
|
108252 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
metestrus then diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.99 |
gx10 |
0.39 |
1.02 |
Randall-Selitto test |
|
|
150 |
min |
0.1% methylcellulose per os |
|
108266 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diestrus then diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
9.91 |
gx10 |
0.36 |
0.95 |
Randall-Selitto test |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108274 |
3101 |
SHR |
systolic blood pressure |
diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
155.11 |
mmHg |
9.41 |
24.89 |
tail cuff plethysmography |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108286 |
3101 |
SHR |
systolic blood pressure |
proestrus |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
169.17 |
mmHg |
1.16 |
3.06 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108296 |
3101 |
SHR |
systolic blood pressure |
proestrus then diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
160.67 |
mmHg |
1.11 |
2.94 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108300 |
3101 |
SHR |
systolic blood pressure |
estrus then diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
163.71 |
mmHg |
2.21 |
5.85 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108318 |
3101 |
SHR |
systolic blood pressure |
metestrus then diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
163.71 |
mmHg |
5.52 |
14.6 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108324 |
3101 |
SHR |
systolic blood pressure |
metestrus then diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
159.14 |
mmHg |
2.35 |
6.23 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108326 |
3101 |
SHR |
systolic blood pressure |
diestrus |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
164.86 |
mmHg |
2.59 |
6.84 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108332 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
control condition |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
9.8 |
gx10 |
0.37 |
0.97 |
Randall-Selitto test |
|
|
0 |
|
|
|
108344 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
control condition |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
9.85 |
gx10 |
0.58 |
1.53 |
Randall-Selitto test |
|
|
0 |
|
|
|
108352 |
3101 |
SHR |
heart rate |
controlled sodium content diet (1 %) (for 14 days) |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
heart pumping trait |
male |
87.0 days
| 24 |
continuous mean |
380.0 |
beats/min |
8.0 |
39.19 |
vascular indwelling catheter method |
femoral artery |
1800 |
0 |
|
pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) |
|
65346 |
306 |
SHR |
mean arterial blood pressure |
controlled sodium content drinking water (1 %) (for 15 days) |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
arterial blood pressure trait |
male |
99.0 days
| 24 |
continuous mean |
170.0 |
mmHg |
3.0 |
14.7 |
vascular indwelling catheter method |
femoral artery |
1800 |
0 |
|
pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) |
|
65348 |
306 |
SHR |
systolic blood pressure |
controlled sodium content drinking water (1 %) (for 15 days) |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
arterial blood pressure trait |
male |
99.0 days
| 24 |
continuous mean |
196.6 |
mmHg |
3.2 |
15.68 |
vascular indwelling catheter method |
femoral artery |
1800 |
0 |
|
pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) |
|
12749 |
306 |
SHR |
systolic blood pressure |
control condition (for 0 hours) |
Cerutti C, et al., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1. |
arterial blood pressure trait |
male |
84.0 days
| 5 |
|
207.0 |
mmHg |
8.0 |
17.89 |
tail cuff plethysmography |
|
0.0 |
0 |
|
|
|
103471 |
2826 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
proestrus then diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
10.09 |
gx10 |
0.66 |
1.75 |
Randall-Selitto test |
|
|
150 |
min |
0.1% methylcellulose per os |
|
108238 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
metestrus then diclofenac (40 mg/kg) (for 0.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
9.26 |
gx10 |
0.35 |
0.92 |
Randall-Selitto test |
|
|
30 |
min |
0.1% methylcellulose per os |
|
108258 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
metestrus then diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
11.87 |
gx10 |
0.57 |
1.52 |
Randall-Selitto test |
|
|
90 |
min |
0.1% methylcellulose per os |
|
108262 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
metestrus then diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.4 |
gx10 |
0.34 |
0.9 |
Randall-Selitto test |
|
|
180 |
min |
0.1% methylcellulose per os |
|
108268 |
3101 |
SHR |
systolic blood pressure |
diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
149.29 |
mmHg |
7.17 |
18.98 |
tail cuff plethysmography |
|
|
150 |
min |
0.1% methylcellulose per os |
|
108292 |
3101 |
SHR |
systolic blood pressure |
proestrus then diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
162.67 |
mmHg |
1.61 |
4.27 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108302 |
3101 |
SHR |
systolic blood pressure |
proestrus then diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
161.67 |
mmHg |
3.51 |
9.29 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108306 |
3101 |
SHR |
systolic blood pressure |
estrus then diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
160.29 |
mmHg |
2.08 |
5.5 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108312 |
3101 |
SHR |
systolic blood pressure |
estrus then diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
161.57 |
mmHg |
1.0 |
2.64 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108314 |
3101 |
SHR |
systolic blood pressure |
estrus then diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
161.86 |
mmHg |
1.49 |
3.93 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108316 |
3101 |
SHR |
systolic blood pressure |
metestrus then diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
165.86 |
mmHg |
3.28 |
8.67 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108330 |
3101 |
SHR |
systolic blood pressure |
diestrus then diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
152.14 |
mmHg |
2.52 |
6.67 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108338 |
3101 |
SHR |
systolic blood pressure |
control condition |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
163.96 |
mmHg |
5.64 |
14.92 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108360 |
3101 |
SHR |
systolic blood pressure |
control condition |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
arterial blood pressure trait |
male |
99.0 days
| 23 |
continuous mean |
188.0 |
mmHg |
2.0 |
9.59 |
vascular indwelling catheter method |
femoral artery |
1800 |
0 |
|
pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) |
|
65347 |
306 |
SHR |
body weight |
controlled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days) |
Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. |
body mass |
male |
360.0 days
| 4 |
|
254.0 |
g |
6.15 |
12.3 |
body weighing method |
|
0 |
0 |
|
|
|
12574 |
268 |
SHR |
body weight |
control condition (for 0 hours) |
Cerutti C, et al., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1. |
body mass |
male |
84.0 days
| 5 |
|
276.0 |
g |
10.0 |
22.36 |
body weighing method |
|
0.0 |
0 |
|
|
|
103477 |
2826 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
9.77 |
gx10 |
0.83 |
2.2 |
Randall-Selitto test |
|
0.0 |
180 |
min |
0.1% methylcellulose per os |
|
108227 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
proestrus |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
9.49 |
gx10 |
0.42 |
1.1 |
Randall-Selitto test |
|
|
0 |
|
|
|
108228 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
estrus then diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
10.31 |
gx10 |
0.49 |
1.3 |
Randall-Selitto test |
|
|
120 |
min |
0.1% methylcellulose per os |
|
108250 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
estrus then diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
7.56 |
gx10 |
0.38 |
1.0 |
Randall-Selitto test |
|
0.0 |
180 |
min |
0.1% methylcellulose per os |
|
108254 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
metestrus then diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
10.86 |
gx10 |
0.7 |
1.84 |
Randall-Selitto test |
|
|
120 |
min |
0.1% methylcellulose per os |
|
108264 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diestrus then diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
11.2 |
gx10 |
0.56 |
1.49 |
Randall-Selitto test |
|
|
90 |
min |
0.1% methylcellulose per os |
|
108276 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diestrus then diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
10.91 |
gx10 |
0.55 |
1.45 |
Randall-Selitto test |
|
|
120 |
min |
0.1% methylcellulose per os |
|
108278 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diestrus then diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.86 |
gx10 |
0.57 |
1.5 |
Randall-Selitto test |
|
|
150 |
min |
0.1% methylcellulose per os |
|
108280 |
3101 |
SHR |
systolic blood pressure |
diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
143.18 |
mmHg |
9.25 |
24.48 |
tail cuff plethysmography |
|
|
90 |
min |
0.1% methylcellulose per os |
|
108288 |
3101 |
SHR |
systolic blood pressure |
estrus then diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
164.0 |
mmHg |
2.97 |
7.85 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108310 |
3101 |
SHR |
systolic blood pressure |
metestrus then diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
171.86 |
mmHg |
5.62 |
14.86 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108322 |
3101 |
SHR |
systolic blood pressure |
diestrus then diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
163.71 |
mmHg |
6.11 |
16.16 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108334 |
3101 |
SHR |
systolic blood pressure |
diestrus then diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
161.14 |
mmHg |
4.01 |
10.62 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108340 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
control condition |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
9.64 |
gx10 |
0.45 |
1.18 |
Randall-Selitto test |
|
|
0 |
|
|
|
108348 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diclofenac (10 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
10.1 |
gx10 |
0.42 |
1.12 |
Randall-Selitto test |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108346 |
3101 |
SHR |
mean arterial blood pressure |
control condition |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
arterial blood pressure trait |
male |
99.0 days
| 23 |
continuous mean |
162.0 |
mmHg |
2.0 |
9.59 |
vascular indwelling catheter method |
femoral artery |
1800 |
0 |
|
pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) |
|
65350 |
306 |
SHR |
heart rate |
control condition (for 98 days) |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
heart pumping trait |
male |
87.0 days
| 23 |
continuous mean |
365.0 |
beats/min |
3.0 |
14.39 |
vascular indwelling catheter method |
femoral artery |
1800 |
0 |
|
pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) |
|
65353 |
306 |
SHR |
heart weight to body weight ratio |
controlled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days) |
Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. |
heart mass |
male |
360.0 days
| 4 |
|
3.5 |
g/kg |
0.05 |
0.1 |
post excision weight measurement |
|
0 |
0 |
|
|
|
12573 |
268 |
SHR |
systolic blood pressure |
controlled sodium content diet (0.4 %) (for 63 days) |
Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. |
arterial blood pressure trait |
male |
91.0 days
| 4 |
serial mean |
181.8 |
mmHg |
1.75 |
3.5 |
tail cuff photoplethysmography |
|
0 |
0 |
|
UR1000; Ueda |
average of 3 consistent readings |
12582 |
268 |
SHR |
heart left ventricle weight to body weight ratio |
control condition (for 0 hours) |
Cerutti C, et al., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1. |
heart left ventricle mass |
male |
84.0 days
| 5 |
|
2.71 |
mg/g |
0.11 |
0.25 |
post excision weight measurement |
|
0.0 |
0 |
|
|
|
103483 |
2826 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
estrus |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.32 |
gx10 |
0.45 |
1.18 |
Randall-Selitto test |
|
|
0 |
|
|
|
108242 |
3101 |
SHR |
systolic blood pressure |
control condition |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
163.57 |
mmHg |
8.15 |
21.55 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108284 |
3101 |
SHR |
systolic blood pressure |
proestrus then diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
162.33 |
mmHg |
0.62 |
1.63 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108304 |
3101 |
SHR |
systolic blood pressure |
estrus |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
169.29 |
mmHg |
2.14 |
5.65 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108308 |
3101 |
SHR |
systolic blood pressure |
metestrus |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
172.71 |
mmHg |
4.73 |
12.51 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108320 |
3101 |
SHR |
systolic blood pressure |
diestrus then diclofenac (40 mg/kg) (for 1.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
151.71 |
mmHg |
4.22 |
11.16 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108336 |
3101 |
SHR |
systolic blood pressure |
diestrus then diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
162.57 |
mmHg |
4.24 |
11.22 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108342 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diclofenac (20 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
10.11 |
gx10 |
0.56 |
1.49 |
Randall-Selitto test |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108350 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
11.03 |
gx10 |
0.63 |
1.66 |
Randall-Selitto test |
|
0.0 |
60 |
min |
0.1% methylcellulose per os |
|
108354 |
3101 |
SHR |
systolic blood pressure |
diclofenac (10 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
165.9 |
mmHg |
1.59 |
4.2 |
tail cuff plethysmography |
|
|
60 |
min |
IP |
|
108358 |
3101 |
SHR |
systolic blood pressure |
control condition |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
163.57 |
mmHg |
8.15 |
21.55 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108364 |
3101 |
SHR |
systolic blood pressure |
diclofenac (20 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
160.57 |
mmHg |
5.22 |
13.81 |
tail cuff plethysmography |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108362 |
3101 |
SHR |
systolic blood pressure |
diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
155.11 |
mmHg |
9.41 |
24.89 |
tail cuff plethysmography |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108366 |
3101 |
SHR |
diastolic blood pressure |
control condition |
Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 |
arterial blood pressure trait |
male |
175.0 days
| 28 |
continuous mean |
148.3 |
mmHg |
2.12 |
11.2 |
vascular indwelling catheter method |
aorta |
|
0 |
|
|
|
11904 |
206 |
SHR |
heart wet weight |
controlled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days) |
Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. |
heart mass |
male |
360.0 days
| 4 |
|
0.88 |
g |
0.01 |
0.02 |
post excision weight measurement |
|
0 |
0 |
|
|
|
12572 |
268 |
SHR |
heart wet weight |
controlled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days) |
Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. |
heart mass |
female |
360.0 days
| 4 |
|
0.68 |
g |
0.05 |
0.09 |
post excision weight measurement |
|
0 |
0 |
|
|
|
12576 |
268 |
SHR |
systolic blood pressure |
controlled sodium content diet (0.4 %) (for 63 days) |
Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. |
arterial blood pressure trait |
female |
91.0 days
| 4 |
serial mean |
152.2 |
mmHg |
6.0 |
12.0 |
tail cuff photoplethysmography |
|
0 |
0 |
|
UR1000; Ueda |
average of 3 consistent readings |
12583 |
268 |
SHR |
heart weight to body weight ratio |
controlled sodium content diet (0.4 %) (for 122 days) then controlled sodium content diet (1.4 %) (for 210 days) |
Inomata H, et al., Hypertens Res 2005 Mar;28(3):273-81. |
heart mass |
female |
360.0 days
| 4 |
|
3.9 |
g/kg |
0.05 |
0.1 |
post excision weight measurement |
|
0 |
0 |
|
|
|
12580 |
268 |
SHR |
body weight |
controlled sodium content diet (1 %) (for 14 days) |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
body mass |
male |
87.0 days
| 24 |
|
269.0 |
g |
6.0 |
29.39 |
body weighing method |
|
0 |
0 |
|
|
|
65429 |
306 |
SHR |
body weight |
control condition (for 98 days) |
Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. |
body mass |
male |
87.0 days
| 23 |
|
271.0 |
g |
4.0 |
19.18 |
body weighing method |
|
0 |
0 |
|
|
|
65428 |
306 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
proestrus then diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
10.61 |
gx10 |
1.14 |
3.02 |
Randall-Selitto test |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108232 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
male |
90.0 days-120.0 days |
7 |
|
11.03 |
gx10 |
1.01 |
2.66 |
Randall-Selitto test |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108219 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
proestrus then diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
12.06 |
gx10 |
0.76 |
2.0 |
Randall-Selitto test |
|
|
120 |
min |
0.1% methylcellulose per os |
|
108236 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
proestrus then diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.96 |
gx10 |
0.7 |
1.86 |
Randall-Selitto test |
|
|
180 |
min |
0.1% methylcellulose per os |
|
108240 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
estrus then diclofenac (40 mg/kg) (for 0.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.39 |
gx10 |
0.37 |
0.97 |
Randall-Selitto test |
|
|
30 |
min |
0.1% methylcellulose per os |
|
108244 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
estrus then diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
9.33 |
gx10 |
0.66 |
1.75 |
Randall-Selitto test |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108246 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
metestrus |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.91 |
gx10 |
0.28 |
0.75 |
Randall-Selitto test |
|
|
0 |
|
|
|
108256 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
metestrus then diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
10.11 |
gx10 |
0.65 |
1.72 |
Randall-Selitto test |
|
|
60 |
min |
0.1% methylcellulose per os |
|
108260 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diestrus |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
9.3 |
gx10 |
0.35 |
0.93 |
Randall-Selitto test |
|
|
0 |
|
|
|
108270 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diestrus then diclofenac (40 mg/kg) (for 0.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
9.14 |
gx10 |
0.43 |
1.14 |
Randall-Selitto test |
|
|
30 |
min |
0.1% methylcellulose per os |
|
108272 |
3101 |
SHR |
measurement of minimal mechanical stimulus needed to elicit evasive reaction |
diestrus then diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
voluntary movement trait |
female |
90.0 days-120.0 days |
7 |
|
8.01 |
gx10 |
0.29 |
0.78 |
Randall-Selitto test |
|
|
180 |
min |
0.1% methylcellulose per os |
|
108282 |
3101 |
SHR |
systolic blood pressure |
diclofenac (40 mg/kg) (for 2 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
143.46 |
mmHg |
7.11 |
18.8 |
tail cuff plethysmography |
|
|
120 |
min |
0.1% methylcellulose per os |
|
108290 |
3101 |
SHR |
systolic blood pressure |
diclofenac (40 mg/kg) (for 3 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
155.93 |
mmHg |
7.57 |
20.02 |
tail cuff plethysmography |
|
|
180 |
min |
0.1% methylcellulose per os |
|
108294 |
3101 |
SHR |
systolic blood pressure |
proestrus then diclofenac (40 mg/kg) (for 1 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
166.83 |
mmHg |
1.0 |
2.64 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108298 |
3101 |
SHR |
systolic blood pressure |
metestrus then diclofenac (40 mg/kg) (for 2.5 hours) |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
female |
90.0 days-120.0 days |
7 |
|
162.14 |
mmHg |
1.74 |
4.6 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108328 |
3101 |
SHR |
systolic blood pressure |
control condition |
Romanowska K, et al., Acta Pol Pharm. 2008 Nov-Dec;65(6):723-9. |
arterial blood pressure trait |
male |
90.0 days-120.0 days |
7 |
|
177.0 |
mmHg |
0.91 |
2.4 |
tail cuff plethysmography |
|
|
0 |
|
|
|
108356 |
3101 |