control condition

 streptozotocin (60 mg/kg/d) then insulin (for 308 days) then enalapril (15 mg/l) (for 175 days)

 streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days)

 streptozotocin (60 mg/kg/d) then insulin (for 371 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 63 days)

 streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 175 days)

 streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days)

 streptozotocin (60 mg/kg/d) then insulin (for 308 days) then anti-Shiga toxin 1 beta monoclonal antibody 13C4 (0.5 mg/kg/d) (for 175 days)

 streptozotocin (60 mg/kg/d) then insulin (for 371 days) then enalapril (15 mg/l) (for 63 days) and anti-transforming growth factor beta antibody (0.5 mg/kg/d) (for 63 days)