Phenominer Database Results (303 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
DRH.F344-(D1Mgh8-D1Mgh12)/Shigm area of individual liver tumorous lesion controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 0.02 mm2 0.0 0.01 ex vivo light microscopy with digital image analysis 0.0 0 67430 750
F344.GK-(D1Arb42a-D1Rat90)/Swe pancreatic islet area to total pancreatic area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. islet of Langerhans morphology trait male 60 days 3 1.27 % 0.13 0.23 ex vivo light microscopy with digital image analysis pancreas 0.0 0 67180 333
DRH/Seac liver tumorous lesion number to liver area ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 1571.9 /cm2 205.35 503.01 ex vivo light microscopy with digital image analysis 0.0 0 /40x field 67408 750
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 33.0 % 8.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67442 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 12820.0 /cm3 2800.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add "liver tumorous lesion number to liver volume ratio" (new term) as child of "calculated liver tumorous lesion number" (new term). 67453 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 3840.0 /cm3 1450.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days Add "liver tumorous lesion number to liver volume ratio" (new term) as child of "calculated liver tumorous lesion number" (new term). 67437 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 9420.0 /cm3 990.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add "liver tumorous lesion number to liver volume ratio" (new term) as child of "calculated liver tumorous lesion number" (new term). 67441 655
MWF/FubRkb kidney glomerulus count control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 28 days 7 N(glom)=1/SSF x 1/ASF x Ps/Pf x ΣQ-/2 27000.0 null 3500.0 9260.13 ex vivo light microscopy with digital image analysis 0.0 0 per kidney 65397 117
MWF-Chr 6SHR/Rkb count of superficial glomeruli directly contacting the kidney surface control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 168 days 19 1.6 null 0.4 1.74 ex vivo light microscopy with digital image analysis 0.0 0 per section 65460 117
F344/DuCrlSwe pancreatic islet area to total pancreatic area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. islet of Langerhans morphology trait male 60 days 3 1.28 % 0.12 0.21 ex vivo light microscopy with digital image analysis pancreas 0.0 0 67178 333
F344/NRrrc intramuscular fat area to body weight ratio control condition Tanomura H, et al., J Vet Med Sci 2002 Jan;64(1):45-50. intramuscular adipose amount male 245 days 7 3.62 (mm2/g)/1000 0.83 2.19 ex vivo light microscopy with digital image analysis 0.0 0 67225 234
F344/NRrrc benign liver tumor number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 16 22.3 null 2.0 8.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days 69151 950
BN/Crl duodenal region pancreatic beta cell weight calculated as the product of pancreas duodenal region weight and corresponding beta cell fractional area fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 1.7 mg 0.12 0.29 ex vivo light microscopy with digital image analysis 0.0 0 68756 1012
BN/Crl splenic region pancreatic beta cell weight calculated as the product of pancreas splenic region weight and corresponding beta cell fractional area fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 3.75 mg 0.28 0.69 ex vivo light microscopy with digital image analysis 0.0 0 68760 1012
BN/Crl calculated total pancreatic islet beta cell weight fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 5.39 mg 0.3 0.73 ex vivo light microscopy with digital image analysis 0.0 0 68764 1012
BN/SsNHsd artery lumen area balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 16 CA = (IEL)2/4π 0.5 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68093 329
SHR/NHsd artery lumen area balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 20 CA = (IEL)2/4π 0.35 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68094 329
BN/SsNHsd artery tunica media thickness balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 16 MW=radius of entire vessel minus radius of circular area 0.03 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68097 329
F344/NRrrc area of liver occupied by tumorous lesions as percentage of total liver area controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 49 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver integrity trait not specified 84 days 8 15.2 % 1.59 4.5 ex vivo light microscopy with digital image analysis 0.0 0 8 wks in text, inconsistent % tumorous foci area in liver 68162 890
SHR/NHsd artery tunica media area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 20 0.1 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69308 1136
SHR.BN-(D3Rat159-D3Rat1)/Mco artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 13 28.31 % ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69311 1136
SHR.BN-(D3Rat159-D3Rat1)/Mco artery neointimal hyperplastic lesion area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 13 0.04 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69312 1136
SHR/NHsd artery tunica media area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.12 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69324 1136
SHR.BN-(D3Rat159-D3Rat1)/Mco artery tunica media area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 13 0.1 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69327 1136
SHR/NHsd artery lumen area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 14 0.54 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69337 1136
SHR/NHsd artery tunica media thickness control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 14 0.05 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69339 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco artery lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.48 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69347 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco artery tunica media area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.12 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69348 1136
BN/Crli volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 0.09 cm3 x 10000 0.02 0.09 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67736 789
F344/Crli volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 80.11 % 6.33 28.32 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67755 789
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 0.18 cm3 x 10000 0.11 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67793 655
MWF kidney sclerotic glomerular volume to total kidney glomerular volume ratio control condition (for 280 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus integrity trait male 280 days 10 35.8 % 3.16 10.0 ex vivo light microscopy with digital image analysis 0.0 0 100259 2459
LEW/Maas ratio of number of glomeruli with microaneurysms to number of total glomeruli anti-Thy1 antibody (2 mg/kg) (between 3 and 21 days) Ijpelaar DH, et al., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5. kidney glomerulus integrity trait female 77 days-105 days 6 6.0 % 2.04 5.0 ex vivo light microscopy with digital image analysis 0.0 7 days ratio of number of glomeruli with microaneurysms to number of total glomeruli 104043 809
LEW/Mol ratio of number of glomeruli with microaneurysms to number of total glomeruli anti-Thy1 antibody (2 mg/kg) (between 3 and 21 days) Ijpelaar DH, et al., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5. kidney glomerulus integrity trait female 77 days-105 days 6 0.0 % 0.0 0.0 ex vivo light microscopy with digital image analysis 0.0 7 days ratio of number of glomeruli with microaneurysms to number of total glomeruli 104044 809
SHR/NHsd artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 0.16 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110455 3107
Hsd:SD artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 15 0.14 mm2 0.02 0.06 ex vivo light microscopy with digital image analysis 0.0 0 110456 3107
MNS/NMco artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 0.13 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110463 3107
SHR/NHsd artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 0.03 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110466 3107
Hsd:SD artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 15 0.03 mm2 0.0 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110467 3107
AS artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 0.04 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110469 3107
WKY/NHsd artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 0.04 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110470 3107
SS/Jr artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.06 mm2 0.02 0.05 ex vivo light microscopy with digital image analysis 0.0 0 110472 3107
F344/NHsd artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 0.05 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110473 3107
DA/OlaHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 38.3 % 5.32 14.08 ex vivo light microscopy with digital image analysis 0.0 0 110487 3107
BN/SsNHsd artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 14 0.18 mm2 0.0 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110491 3107
BN/SsNHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 46.3 % 1.71 5.41 ex vivo light microscopy with digital image analysis 0.0 0 110493 3107
BN/SsNHsd circular vessel area sham surgical control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 11 0.28 mm2 0.03 0.1 ex vivo light microscopy with digital image analysis 0.0 0 110497 3107
SHR/NHsd circular vessel area control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 12 0.4 mm2 0.06 0.22 ex vivo light microscopy with digital image analysis 0.0 0 110499 3107
BN/SsNHsd artery lumen area control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 23 0.48 mm2 0.02 0.1 ex vivo light microscopy with digital image analysis 0.0 0 110503 3107
MWF/FubRkb kidney glomerular density control condition Freese A, etal., J Perinat Med. 2013 May;41(3):295-9. doi: 10.1515/jpm-2012-0178. kidney glomerulus quantity not specified 7 days 15 11.3 /mm3 2.6 10.07 ex vivo light microscopy with digital image analysis 0.0 0 number of glomeruli per volume of kidney (CMO:0003799) 110787 3187
MWF/FubRkb kidney glomerulus count control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney glomerulus quantity male 28 days 7 N(glom)=1/SSF x 1/ASF x Ps/Pf x ΣQ-/2 27028.0 null 1322.0 3497.68 ex vivo light microscopy with digital image analysis 0.0 0 108972 3133
F344/Jcl area of individual ventral prostate tumorous lesion with round, irregular size nuclei control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 8 0.22 mm2 0.11 0.3 ex vivo light microscopy with digital image analysis 0.0 0 109962 341
F344/NRrrc percentage of study population developing benign liver tumors during a period of time N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 16 100.0 % 5.4 21.6 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days benign liver tumor incidence 69150 950
F344/Jcl area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 8 0.25 % ex vivo light microscopy with digital image analysis 0.0 0 67947 341
WKY kidney sclerotic glomerular volume to total kidney glomerular volume ratio control condition (for 280 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus integrity trait male 280 days 9 0.3 % 0.13 0.4 ex vivo light microscopy with digital image analysis 0.0 0 100260 2459
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 69.0 % 9.8 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67458 655
DRH/Seac area of individual liver tumorous lesion controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 0.01 mm2 0.0 0.0 ex vivo light microscopy with digital image analysis 0.0 0 67431 750
DRH/Seac area of liver occupied by fibrotic lesions to total liver area ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 5.7 % 0.33 0.8 ex vivo light microscopy with digital image analysis 0.0 0 67434 750
F344/DuCrlSwe beta cell area to total pancreatic islet area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. pancreatic beta cell morphology trait male 60 days 3 61.1 % 1.1 1.91 ex vivo light microscopy with digital image analysis 0.0 0 67185 333
ACI/SegHsd area of individual prostate tumorous lesion control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 12 1.78 mm2 ex vivo light microscopy with digital image analysis 0 0 65838 341
MWF/FubRkb count of superficial glomeruli not directly contacting the kidney surface control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 168 days 18 16.7 null 1.1 4.67 ex vivo light microscopy with digital image analysis 0.0 0 per section 65458 117
MWF/FubRkb count of superficial glomeruli directly contacting the kidney surface control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 168 days 18 3.8 null 0.8 3.39 ex vivo light microscopy with digital image analysis 0.0 0 per section 65461 117
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 3 40.6 % 5.4 9.35 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 224 days remodeling/total ratio 69149 950
BN/Crl duodenal region pancreatic beta cell weight calculated as the product of pancreas duodenal region weight and corresponding beta cell fractional area fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 1.38 mg 0.1 0.24 ex vivo light microscopy with digital image analysis 0.0 0 68757 1012
GK/Ox splenic region pancreatic beta cell weight calculated as the product of pancreas splenic region weight and corresponding beta cell fractional area fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 1.22 mg 0.26 0.64 ex vivo light microscopy with digital image analysis 0.0 0 68763 1012
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 3.55 % 0.98 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68107 655
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 10.67 % 1.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68109 655
F344/NHsd volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 12 2.95 cm3 x 10000 0.35 312.98 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68351 912
SHR/NHsd artery tunica media thickness balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 20 MW=radius of entire vessel minus radius of circular area 0.04 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68098 329
SHR/NHsd artery neointimal hyperplastic lesion area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 20 0.01 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69306 1136
SHR.BN-(D3Rat159-D3Rat1)/Mco artery tunica media area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 13 0.08 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69314 1136
SHR.BN-(D3Rat159-D3Rat1)/Mco artery tunica media thickness balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 13 0.04 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69315 1136
SHR.BN-(D6Rat40-D6Rat170)/Mco artery lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 25 0.45 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69319 1136
SHR.BN-(D6Rat40-D6Rat170)/Mco artery tunica media area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 25 0.11 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69320 1136
SHR/NHsd artery lumen area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.45 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69323 1136
SHR/NHsd artery tunica media thickness control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.05 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69325 1136
SHR.BN-(D6Rat40-D6Rat170)/Mco artery tunica media area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 25 0.14 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69330 1136
SHR/NHsd artery neointimal hyperplastic lesion area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 15 0.02 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69336 1136
ACI/SegHsd area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 12 1.61 % ex vivo light microscopy with digital image analysis 0.0 0 67946 341
COP liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy (for 202.5 days) De Miglio MR, et al., Int J Cancer 2004 Aug 10;111(1):9-16. liver integrity trait male 0 days 10 83.0 % ex vivo light microscopy with digital image analysis liver 0.0 224 days 70203 1302
SHR/NHsd artery tunica media area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 15 0.1 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69352 1136
SS.MNS-(D2Mit6-Adh1)/Ayd aorta smooth muscle cell count per unit vessel length controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. blood vessel smooth muscle cell quantity male 98 days 5 58.0 /um 9.0 20.12 ex vivo light microscopy with digital image analysis 0.0 0 69030 1096
F344/Crli liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 7875.0 /cm3 624.0 2790.61 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight need to update double congenicstrain 67713 789
BN/Crli liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 11142.0 /cm3 930.0 4159.09 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight update term and unit 67721 789
MWF kidney glomerulus volume control condition (for 280 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus morphology trait male 280 days 10 1.75 x 10E6 um3 0.06 0.2 ex vivo light microscopy with digital image analysis 0.0 0 100251 2459
WKY kidney glomerulus volume control condition (for 280 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus morphology trait male 280 days 9 0.7 x 10E6 um3 0.02 0.07 ex vivo light microscopy with digital image analysis 0.0 0 100252 2459
MWF kidney sclerotic glomeruli count to total glomeruli count ratio control condition (for 420 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus integrity trait male 420 days 10 99.0 % 0.63 2.0 ex vivo light microscopy with digital image analysis 0.0 0 100257 2459
LEW/Maas ratio of number of glomeruli with microaneurysms to number of total glomeruli anti-Thy1 antibody (2 mg/kg) (between 3 and 21 days) Ijpelaar DH, et al., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5. kidney glomerulus integrity trait female 77 days-105 days 6 22.1 % 3.8 9.3 ex vivo light microscopy with digital image analysis 0.0 3 days ratio of number of glomeruli with microaneurysms to number of total glomeruli 104041 809
LEW/Maas ratio of glomerular area occupied by activated mesangial cells to total glomerular area anti-Thy1 antibody (2 mg/kg) (between 3 and 21 days) Ijpelaar DH, et al., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5. mesangial cell morphology trait female 77 days-105 days 6 26.1 % 5.84 14.3 ex vivo light microscopy with digital image analysis 0.0 7 days ratio of glomerular area occupied by activated mesangial cells to total glomerular area 104047 809
LEW/SsNHsd artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.13 mm2 0.01 0.04 ex vivo light microscopy with digital image analysis 0.0 0 110460 3107
ACI/SegHsd area of ventral prostate occupied by tumorous lesions with solid structure to total ventral prostate area ratio control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 12 1.09 % 0.38 1.31 ex vivo light microscopy with digital image analysis 0.0 0 109891 341
BN/SsNHsd artery lumen area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 23 0.41 mm2 0.03 0.13 ex vivo light microscopy with digital image analysis 0.0 0 110505 3107
SHR/NHsd circular vessel area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 19 0.46 mm2 0.05 0.22 ex vivo light microscopy with digital image analysis 0.0 0 110507 3107
BN/SsNHsd circular vessel area control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 11 0.35 mm2 389.0 1290.17 ex vivo light microscopy with digital image analysis 0.0 0 110494 3107
BN/SsNHsd artery lumen area control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 11 0.35 mm2 0.04 0.13 ex vivo light microscopy with digital image analysis 0.0 0 110496 3107
LEW/SsNHsd artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.04 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110471 3107
MNS/NMco artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 0.04 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110474 3107
SR/Jr artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 8 21.9 % 4.98 14.09 ex vivo light microscopy with digital image analysis 0.0 0 110479 3107
MNS/NMco artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 32.0 % 5.97 15.8 ex vivo light microscopy with digital image analysis 0.0 0 110485 3107
SHR/NHsd artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.04 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110489 3107
SR/Jr artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 8 0.16 mm2 0.01 0.03 ex vivo light microscopy with digital image analysis 0.0 0 110457 3107
BN/SsNHsd artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.14 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110464 3107
MWF-Chr 8SHR/Rkb kidney fibrotic lesion area to total kidney area ratio control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney integrity trait female 168 days 10 3.3 % 0.1 0.32 ex vivo light microscopy with digital image analysis kidney 0.0 0 108983 3133
ACI/SegHsd area of individual ventral prostate tumorous lesion with round, irregular size nuclei control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 12 1.73 mm2 0.36 1.24 ex vivo light microscopy with digital image analysis 0.0 0 109961 341
ACI/SegHsd area of ventral prostate occupied by tumorous lesions with round, irregular size nuclei to total ventral prostate area ratio control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 12 1.57 % 0.38 1.31 ex vivo light microscopy with digital image analysis 0.0 0 109963 341
F344/Seac liver tumorous lesion number to liver area ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 6036.1 /cm2 693.06 1697.65 ex vivo light microscopy with digital image analysis 0.0 0 /40x field 67402 750
SHR.BN-(D6Rat40-D6Rat170)/Mco lesioned artery residual lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 25 0.04 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69322 1136
SHR.BN-(D6Rat40-D6Rat170)/Mco artery lumen area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 25 0.5 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69329 1136
SS/Jr aorta smooth muscle cell count per unit vessel length controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. blood vessel smooth muscle cell quantity male 98 days 10 90.0 /um 4.0 12.65 ex vivo light microscopy with digital image analysis 0.0 0 /um - calculated aortic smooth muscle cell count 69034 1096
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy then 5-bromo-2'-deoxyuridine (50 mg/kg) (for 2 hours) Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 5 1070.0 % 143.0 319.76 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69143 950
SHR/NHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery integrity trait male 133 days-140 days 20 11.6 % ex vivo light microscopy with digital image analysis 0.0 0 % nih area - error - % coefficient of variation 68102 329
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 6.42 % 0.99 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68106 655
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 15.33 % 0.74 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68110 655
BN/Crl ratio of insulin-positive cell area to total area of splenic region of pancreas fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 0.75 % 0.13 0.32 ex vivo light microscopy with digital image analysis 0.0 0 68752 1012
BN/SsNHsd volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 7 19.83 % 2.09 5.53 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68354 912
MWF kidney sclerotic glomeruli count to total glomeruli count ratio control condition (for 280 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus integrity trait male 280 days 10 87.0 % 2.21 7.0 ex vivo light microscopy with digital image analysis 0.0 0 100255 2459
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 11630.0 /cm3 890.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days Add "liver tumorous lesion number to liver volume ratio" (new term) as child of "calculated liver tumorous lesion number" (new term). 67449 655
F344.GK-(D1Got250-D1Rat90)/Swe beta cell area to total pancreatic islet area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. pancreatic beta cell morphology trait male 60 days 3 59.7 % 1.1 1.91 ex vivo light microscopy with digital image analysis 0.0 0 67463 333
DRH.F344-(D1Mgh8-D1Mgh12)/Shigm area of liver occupied by fibrotic lesions to total liver area ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 11.3 % 1.18 2.9 ex vivo light microscopy with digital image analysis 0.0 0 67433 750
F344.GK-(D1Rat83-D1Rat376)/Swe pancreatic islet area to total pancreatic area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. islet of Langerhans morphology trait male 60 days 3 1.23 % 0.14 0.24 ex vivo light microscopy with digital image analysis pancreas 0.0 0 67183 333
F344.GK-(D1Rat175-D1Rat90)/Swe pancreatic islet area to total pancreatic area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. islet of Langerhans morphology trait male 60 days 3 1.45 % 0.13 0.23 ex vivo light microscopy with digital image analysis pancreas 0.0 0 67193 333
DRH.F344-(D1Mgh8-D1Mgh12)/Shigm liver tumorous lesion number to liver area ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 5407.34 /cm2 359.37 880.26 ex vivo light microscopy with digital image analysis 0.0 0 /40x field 67407 750
F344/Seac area of liver occupied by tumorous lesions as percentage of total liver area controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 44.2 % 2.12 5.2 ex vivo light microscopy with digital image analysis 0.0 0 per 40X field 67414 750
DRH.F344-(D1Mgh8-D1Mgh12)/Shigm area of liver occupied by tumorous lesions as percentage of total liver area controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 12.6 % 1.14 2.8 ex vivo light microscopy with digital image analysis 0.0 0 per 40X field 67415 750
DRH/Seac TUNEL-positive cell number to total cell number ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. hepatocyte apoptosis trait male 84 days 6 57.9 % 2.98 7.3 ex vivo light microscopy with digital image analysis liver 0.0 56 days tunel hepatocytes to total hepatocytes ratio 67548 750
MWF-Chr 6SHR/Rkb kidney glomerulus count control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 28 days 7 N(glom)=1/SSF x 1/ASF x Ps/Pf x ΣQ-/2 34600.0 null 5700.0 15080.78 ex vivo light microscopy with digital image analysis 0.0 0 per kidney 65398 117
MWF-Chr 6SHR/Rkb count of superficial glomeruli not directly contacting the kidney surface control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 168 days 19 15.2 null 1.1 4.79 ex vivo light microscopy with digital image analysis 0.0 0 per section 65457 117
SHR/FubRkb count of superficial glomeruli directly contacting the kidney surface control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 168 days 10 0.0 null 0.0 0.0 ex vivo light microscopy with digital image analysis 0.0 0 per section 65459 117
F344/Seac area of liver occupied by fibrotic lesions to total liver area ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 17.9 % 1.35 3.3 ex vivo light microscopy with digital image analysis 0.0 0 67432 750
OLETF intramuscular fat area to body weight ratio control condition Tanomura H, et al., J Vet Med Sci 2002 Jan;64(1):45-50. intramuscular adipose amount male 245 days 7 5.01 (mm2/g)/1000 0.87 2.29 ex vivo light microscopy with digital image analysis 0.0 0 67224 234
BN liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy then 5-bromo-2'-deoxyuridine (50 mg/kg) (for 2 hours) Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 5 180.0 % 4.0 8.94 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69144 950
F344/NRrrc malignant liver tumor number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 16 2.2 null 0.2 0.8 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days check malignant 69153 950
SHR/Fub kidney fibrotic lesion area to total kidney area ratio control condition Schulz A, et al., J Am Soc Nephrol 2003 Dec;14(12):3081-9. kidney integrity trait male 126 days 8 2.4 % 0.11 0.3 ex vivo light microscopy with digital image analysis 0.0 0 67838 325
GK/Ox duodenal region pancreatic beta cell weight calculated as the product of pancreas duodenal region weight and corresponding beta cell fractional area fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 0.87 mg 0.2 0.49 ex vivo light microscopy with digital image analysis 0.0 0 68758 1012
BN/Crl splenic region pancreatic beta cell weight calculated as the product of pancreas splenic region weight and corresponding beta cell fractional area fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 3.59 mg 0.21 0.51 ex vivo light microscopy with digital image analysis 0.0 0 68761 1012
BN/SsNHsd artery lumen area control condition Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 12 CA = (IEL)2/4π 0.45 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68087 329
BN/SsNHsd artery neointimal hyperplastic lesion area balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery integrity trait male 133 days-140 days 16 0.03 mm2 ex vivo light microscopy with digital image analysis 0.0 0 nih area - error - % coefficient of variation 68099 329
SHR/NHsd artery neointimal hyperplastic lesion area balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery integrity trait male 133 days-140 days 20 0.01 mm2 ex vivo light microscopy with digital image analysis 0.0 0 nih area - error - % coefficient of variation 68100 329
BN/SsNHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery integrity trait male 133 days-140 days 16 27.1 % ex vivo light microscopy with digital image analysis 0.0 0 % nih area - error - % coefficient of variation 68101 329
BN/SsNHsd lesioned artery residual lumen area balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery integrity trait male 133 days-140 days 16 LS (lumen size) = CA - NIH area 0.47 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68103 329
F344/NHsd volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 12 84.18 % 3.64 12.61 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68353 912
BN/SsNHsd liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 7 155800.0 null 19408.0 51348.74 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days CMO:0001068 68350 912
DRH/Seac liver tumorous lesion number to liver area ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 49 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver integrity trait not specified 84 days 10 23.8 /cm2 2.75 8.7 ex vivo light microscopy with digital image analysis 0.0 0 8 wks in text, inconsistent 68158 890
GK/Ox ratio of insulin-positive cell area to total area of splenic region of pancreas fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 0.34 % 0.05 0.12 ex vivo light microscopy with digital image analysis 0.0 0 68754 1012
SHR/NHsd artery lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 20 0.38 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69307 1136
SHR/NHsd lesioned artery residual lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 20 0.37 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69310 1136
SHR.BN-(D3Rat159-D3Rat1)/Mco artery lumen area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 13 0.39 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69326 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco artery tunica media area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.14 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69344 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco lesioned artery residual lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 17 0.45 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69350 1136
F344/NRrrc liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female 0 days 3 1424.0 null 242.0 419.16 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68617 950
BN liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female 0 days 3 1717.0 null 227.0 393.18 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68618 950
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 4.76 cm3 x 10000 0.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67791 655
FHH.PCK-(D9Rat35-D9Rat70)/Mcwi area of liver occupied by fibrotic lesions to total liver area ratio control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. liver integrity trait male 120 days 8 21.3 % 5.6 15.84 ex vivo light microscopy with digital image analysis 0.0 0 Masson¿s Trichrome staining 96912 1738
ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi ratio of the area occupied by protein casts to the total area of the kidney outer medulla outer stripe and cortex right nephrectomy (for 42 days) then controlled sodium content diet (0.4 %) (for 42 days) O'Meara CC, et al., J Am Soc Nephrol. 2011 Mar;22(3):518-25. Epub 2010 Dec 2. kidney integrity trait male 84 days 4 3.29 % 0.43 0.86 ex vivo light microscopy with digital image analysis 0.0 42 days area of cast to kidney area ratio 84749 1600
ACI.FHH-(D1Mit18-D1Rat90)(D3Rat6-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi ratio of the area occupied by protein casts to the total area of the kidney outer medulla outer stripe and cortex right nephrectomy (for 42 days) then controlled sodium content diet (0.4 %) (for 42 days) O'Meara CC, et al., J Am Soc Nephrol. 2011 Mar;22(3):518-25. Epub 2010 Dec 2. kidney integrity trait male 84 days 3 1.18 % 0.26 0.45 ex vivo light microscopy with digital image analysis 0.0 42 days area of cast to kidney area ratio 84750 1600
ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Eur ratio of the area occupied by protein casts to the total area of the kidney outer medulla outer stripe and cortex right nephrectomy (for 42 days) then controlled sodium content diet (0.4 %) (for 42 days) O'Meara CC, et al., J Am Soc Nephrol. 2011 Mar;22(3):518-25. Epub 2010 Dec 2. kidney integrity trait male 84 days 4 0.78 % 0.17 0.34 ex vivo light microscopy with digital image analysis 0.0 42 days area of cast to kidney area ratio 84751 1600
MWF kidney sclerotic glomerular volume to total kidney glomerular volume ratio control condition (for 420 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus integrity trait male 420 days 10 62.0 % 3.1 9.8 ex vivo light microscopy with digital image analysis 0.0 0 100261 2459
F344/Jcl area of individual ventral prostate tumorous lesion with a solid structure control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 8 0.06 mm2 0.05 0.14 ex vivo light microscopy with digital image analysis 0.0 0 109890 341
SHR/NHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 15.1 % 2.98 8.94 ex vivo light microscopy with digital image analysis 0.0 0 110477 3107
SS/Jr artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 28.3 % 6.87 21.72 ex vivo light microscopy with digital image analysis 0.0 0 110483 3107
BN/SsNHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 35.2 % 2.34 7.4 ex vivo light microscopy with digital image analysis 0.0 0 110486 3107
F344/NHsd artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 0.17 mm2 0.03 0.08 ex vivo light microscopy with digital image analysis 0.0 0 110462 3107
SR/Jr artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 8 0.04 mm2 0.01 0.03 ex vivo light microscopy with digital image analysis 0.0 0 110468 3107
SHR/NHsd artery lumen area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 19 0.43 mm2 0.04 0.19 ex vivo light microscopy with digital image analysis 0.0 0 110509 3107
Hsd:WI kidney glomerular density control condition Freese A, etal., J Perinat Med. 2013 May;41(3):295-9. doi: 10.1515/jpm-2012-0178. kidney glomerulus quantity not specified -2 days 15 17.5 /mm3 1.1 4.26 ex vivo light microscopy with digital image analysis 0.0 0 number of glomeruli per volume of kidney (CMO:0003799) 110786 3187
SHR/NHsd circular vessel area sham surgical control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 12 0.34 mm2 0.02 0.08 ex vivo light microscopy with digital image analysis 0.0 0 110498 3107
SHR/NHsd artery lumen area sham surgical control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 12 0.34 mm2 0.23 0.78 ex vivo light microscopy with digital image analysis 0.0 0 110500 3107
F344/Jcl area of ventral prostate occupied by tumorous lesions with round, irregular size nuclei to total ventral prostate area ratio control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 8 0.24 % 0.12 0.33 ex vivo light microscopy with digital image analysis 0.0 0 109964 341
DRH.F344-(D1Mgh8-D1Mgh12)/Shigm TUNEL-positive cell number to total cell number ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. hepatocyte apoptosis trait male 84 days 6 2.9 % 0.61 1.5 ex vivo light microscopy with digital image analysis liver 0.0 56 days tunel hepatocytes to total hepatocytes ratio 67547 750
F344/Jcl area of individual prostate tumorous lesion control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 8 0.22 mm2 ex vivo light microscopy with digital image analysis 0 0 65839 341
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 10.0 % 4.1 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67450 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 38.6 null 12.06 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 224 days intraperitoneal per liver 67459 655
F344.GK-(D1Mgh14-D1Rat90)/Swe beta cell area to total pancreatic islet area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. pancreatic beta cell morphology trait male 60 days 3 57.4 % 1.2 2.08 ex vivo light microscopy with digital image analysis 0.0 0 67464 333
F344.GK-(D1Swe4-D1Rat85)/Swe beta cell area to total pancreatic islet area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. pancreatic beta cell morphology trait male 60 days 3 60.4 % 1.1 1.91 ex vivo light microscopy with digital image analysis 0.0 0 67466 333
DRH/Seac area of liver occupied by tumorous lesions as percentage of total liver area controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 3.0 % 0.65 1.6 ex vivo light microscopy with digital image analysis 0.0 0 per 40X field 67416 750
SHR/NHsd artery tunica media thickness balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 15 0.04 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69353 1136
SHR/NHsd artery tunica media thickness balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 20 0.04 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69309 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco artery tunica media thickness control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.05 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69345 1136
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 0.47 cm3 x 10000 0.13 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67792 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 0.16 cm3 x 10000 0.09 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67794 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 3.9 cm3 x 10000 0.74 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67796 655
F344/NRrrc percentage of study population developing malignant liver tumors during a period of time N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 16 100.0 % 5.4 21.6 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days check malignant 69152 950
F344/NHsd liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 12 126820.0 null 9698.0 33594.86 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days CMO:0001068 68349 912
GK/Ox ratio of insulin-positive cell area to total area of duodenal region of pancreas fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 0.34 % 0.06 0.15 ex vivo light microscopy with digital image analysis 0.0 0 ratio of duodenal IPCA 68750 1012
GK/Ox ratio of insulin-positive cell area to total area of splenic region of pancreas fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 0.34 % 0.04 0.1 ex vivo light microscopy with digital image analysis 0.0 0 68755 1012
BN/SsNHsd volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 7 0.12 cm3 x 10000 0.03 0.07 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68352 912
F344/NRrrc intramuscular fat area control condition Tanomura H, et al., J Vet Med Sci 2002 Jan;64(1):45-50. intramuscular adipose amount male 245 days 7 1.34 mm2 0.14 0.38 ex vivo light microscopy with digital image analysis 0.0 0 67223 234
LEW/Mol ratio of number of glomeruli with microaneurysms to number of total glomeruli anti-Thy1 antibody (2 mg/kg) (between 3 and 21 days) Ijpelaar DH, et al., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5. kidney glomerulus integrity trait female 77 days-105 days 6 1.3 % 0.78 1.9 ex vivo light microscopy with digital image analysis 0.0 3 days ratio of number of glomeruli with microaneurysms to number of total glomeruli 104042 809
LEW/Maas ratio of glomerular area occupied by activated mesangial cells to total glomerular area anti-Thy1 antibody (2 mg/kg) (between 3 and 21 days) Ijpelaar DH, et al., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5. mesangial cell morphology trait female 77 days-105 days 6 1.0 % 0.69 1.7 ex vivo light microscopy with digital image analysis 0.0 3 days ratio of glomerular area occupied by activated mesangial cells to total glomerular area 104045 809
LEW/Mol ratio of glomerular area occupied by activated mesangial cells to total glomerular area anti-Thy1 antibody (2 mg/kg) (between 3 and 21 days) Ijpelaar DH, et al., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5. mesangial cell morphology trait female 77 days-105 days 6 9.4 % 1.92 4.7 ex vivo light microscopy with digital image analysis 0.0 7 days ratio of glomerular area occupied by activated mesangial cells to total glomerular area 104048 809
MWF kidney sclerotic glomeruli count to total glomeruli count ratio controlled lisinopril content drinking water (80-100 mg/l) (for 140 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus integrity trait male 420 days 10 85.0 % 2.53 8.0 ex vivo light microscopy with digital image analysis 0.0 0 100258 2459
F344.GK-(D1Mgh14-D1Rat90)/Swe pancreatic islet area to total pancreatic area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. islet of Langerhans morphology trait male 60 days 3 1.07 % 0.12 0.21 ex vivo light microscopy with digital image analysis pancreas 0.0 0 67182 333
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 59.0 % 9.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67438 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 16820.0 /cm3 5100.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add 67445 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion diameter measurement N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 4.19 mm 1.3 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 224 days intraperitoneal 67460 655
F344.GK-(D1Rat175-D1Rat90)/Swe beta cell area to total pancreatic islet area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. pancreatic beta cell morphology trait male 60 days 3 58.7 % 1.1 1.91 ex vivo light microscopy with digital image analysis 0.0 0 67462 333
F344/Seac TUNEL-positive cell number to total cell number ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. hepatocyte apoptosis trait male 84 days 6 1.3 % 0.33 0.8 ex vivo light microscopy with digital image analysis liver 0.0 56 days tunel hepatocytes to total hepatocytes ratio 67545 750
OLETF intramuscular fat area control condition Tanomura H, et al., J Vet Med Sci 2002 Jan;64(1):45-50. intramuscular adipose amount male 245 days 7 3.26 mm2 0.2 0.52 ex vivo light microscopy with digital image analysis 0.0 0 67222 234
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 5 30.4 % 2.7 6.04 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 105 days remodeling/total ratio 69146 950
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 5 15.1 % 1.1 2.46 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 224 days remodeling/total ratio 69147 950
GK/Ox duodenal region pancreatic beta cell weight calculated as the product of pancreas duodenal region weight and corresponding beta cell fractional area fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 0.95 mg 0.08 0.2 ex vivo light microscopy with digital image analysis 0.0 0 68759 1012
BN/Crl calculated total pancreatic islet beta cell weight fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 4.9 mg 0.19 0.47 ex vivo light microscopy with digital image analysis 0.0 0 68765 1012
MWF/Fub kidney fibrotic lesion area to total kidney area ratio control condition Schulz A, et al., J Am Soc Nephrol 2003 Dec;14(12):3081-9. kidney integrity trait male 126 days 8 6.4 % 0.28 0.8 ex vivo light microscopy with digital image analysis 0.0 0 67837 325
BN/Crl ratio of insulin-positive cell area to total area of duodenal region of pancreas fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 0.67 % 0.07 0.17 ex vivo light microscopy with digital image analysis 0.0 0 ratio of duodenal IPCA 68748 1012
BN/Crl ratio of insulin-positive cell area to total area of duodenal region of pancreas fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 0.56 % 0.12 0.29 ex vivo light microscopy with digital image analysis 0.0 0 ratio of duodenal IPCA 68749 1012
GK/Ox ratio of insulin-positive cell area to total area of duodenal region of pancreas fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 0.39 % 0.06 0.15 ex vivo light microscopy with digital image analysis 0.0 0 ratio of duodenal IPCA 68751 1012
SHR/NHsd artery tunica media area control condition Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 18 0.09 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68090 329
BN/SsNHsd artery tunica media thickness control condition Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 12 MW=radius of entire vessel minus radius of circular area 0.04 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68091 329
SHR/NHsd lesioned artery residual lumen area balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery integrity trait male 133 days-140 days 20 LS (lumen size) = CA - NIH area 0.34 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68104 329
F344/NRrrc liver tumorous lesion number to liver area ratio controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 49 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver integrity trait not specified 84 days 8 120.0 /cm2 4.95 14.0 ex vivo light microscopy with digital image analysis 0.0 0 8 wks in text, inconsistent 68157 890
F344/NRrrc liver tumorous lesion number controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 140 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver integrity trait not specified 175 days 11 6.5 null 0.27 0.9 ex vivo light microscopy with digital image analysis 0.0 0 68166 890
SHR/NHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 20 9.63 % ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69305 1136
SHR.BN-(D6Rat40-D6Rat170)/Mco artery neointimal hyperplastic lesion area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 25 0.02 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69318 1136
SHR.BN-(D6Rat40-D6Rat170)/Mco artery tunica media thickness balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 25 0.04 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69321 1136
SHR.BN-(D3Rat159-D3Rat1)/Mco artery tunica media thickness control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 13 0.04 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69328 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 17 23.76 % ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69341 1136
SS.MNS-(D2Mit6-D2Rat303)/Ayd aorta smooth muscle cell count per unit vessel length controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. blood vessel smooth muscle cell quantity male 98 days 8 134.0 /um 21.0 59.4 ex vivo light microscopy with digital image analysis 0.0 0 /um - calculated aortic smooth muscle cell count 69032 1096
BN/Crli volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 13.69 % 1.99 8.9 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67758 789
SHR/NHsd artery lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 15 0.44 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69351 1136
MWF kidney glomerulus volume control condition (for 420 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus morphology trait male 420 days 10 1.85 x 10E6 um3 0.08 0.25 ex vivo light microscopy with digital image analysis 0.0 0 100253 2459
WKY kidney sclerotic glomeruli count to total glomeruli count ratio control condition (for 280 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus integrity trait male 280 days 9 4.0 % 1.33 4.0 ex vivo light microscopy with digital image analysis 0.0 0 100256 2459
LEW/Mol ratio of glomerular area occupied by activated mesangial cells to total glomerular area anti-Thy1 antibody (2 mg/kg) (between 3 and 21 days) Ijpelaar DH, et al., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5. mesangial cell morphology trait female 77 days-105 days 6 1.0 % 0.37 0.9 ex vivo light microscopy with digital image analysis 0.0 3 days ratio of number of glomeruli with microaneurysms to number of total glomeruli 104046 809
ACI/SegHsd area of individual ventral prostate tumorous lesion with a solid structure control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 12 1.17 mm2 0.36 1.25 ex vivo light microscopy with digital image analysis 0.0 0 109889 341
DA/OlaHsd artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 0.11 mm2 0.01 0.03 ex vivo light microscopy with digital image analysis 0.0 0 110465 3107
DA/OlaHsd artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 0.04 mm2 0.01 0.01 ex vivo light microscopy with digital image analysis 0.0 0 110476 3107
AS artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 24.5 % 5.01 13.26 ex vivo light microscopy with digital image analysis 0.0 0 110480 3107
MWF/FubRkb kidney glomerular density control condition Freese A, etal., J Perinat Med. 2013 May;41(3):295-9. doi: 10.1515/jpm-2012-0178. kidney glomerulus quantity not specified -2 days 15 11.9 /mm3 1.8 6.97 ex vivo light microscopy with digital image analysis 0.0 0 number of glomeruli per volume of kidney (CMO:0003799) 110785 3187
SHR/NHsd artery lumen area control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 12 0.4 mm2 0.06 0.22 ex vivo light microscopy with digital image analysis 0.0 0 110501 3107
BN/SsNHsd circular vessel area control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 23 0.48 mm2 0.02 0.1 ex vivo light microscopy with digital image analysis 0.0 0 110502 3107
BN/SsNHsd circular vessel area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 23 0.47 mm2 0.03 0.15 ex vivo light microscopy with digital image analysis 0.0 0 110504 3107
SHR/NHsd artery lumen area control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 19 0.59 mm2 0.08 0.36 ex vivo light microscopy with digital image analysis 0.0 0 110508 3107
BN/SsNHsd circular vessel area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 23 0.47 mm2 0.03 0.15 ex vivo light microscopy with digital image analysis 0.0 0 110510 3107
MWF-Chr 8SHR/Rkb kidney glomerulus count control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney glomerulus quantity male 28 days 7 N(glom)=1/SSF x 1/ASF x Ps/Pf x ΣQ-/2 23771.0 null 1352.0 3577.06 ex vivo light microscopy with digital image analysis 0.0 0 108971 3133
SHR/FubRkb kidney glomerulus count control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney glomerulus quantity male 28 days 7 N(glom)=1/SSF x 1/ASF x Ps/Pf x ΣQ-/2 36979.0 null 1352.0 3577.06 ex vivo light microscopy with digital image analysis 0.0 0 108973 3133
SHR/FubRkb kidney fibrotic lesion area to total kidney area ratio control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney integrity trait male 168 days 10 3.1 % 0.2 0.63 ex vivo light microscopy with digital image analysis kidney 0.0 0 108980 3133
MWF/FubRkb kidney fibrotic lesion area to total kidney area ratio control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney integrity trait male 168 days 10 7.5 % 0.5 1.58 ex vivo light microscopy with digital image analysis kidney 0.0 0 108984 3133
MWF/FubRkb kidney fibrotic lesion area to total kidney area ratio control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney integrity trait female 168 days 10 4.9 % 0.3 0.95 ex vivo light microscopy with digital image analysis kidney 0.0 0 108985 3133
F344.GK-(D1Got250-D1Rat90)/Swe pancreatic islet area to total pancreatic area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. islet of Langerhans morphology trait male 60 days 3 1.08 % 0.08 0.14 ex vivo light microscopy with digital image analysis pancreas 0.0 0 67181 333
F344.GK-(D1Swe4-D1Rat85)/Swe pancreatic islet area to total pancreatic area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. islet of Langerhans morphology trait male 60 days 3 1.26 % 0.11 0.19 ex vivo light microscopy with digital image analysis pancreas 0.0 0 67184 333
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 19.0 % 5.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67446 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 19.0 % 4.2 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67454 655
F344.GK-(D1Arb42a-D1Rat90)/Swe beta cell area to total pancreatic islet area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. pancreatic beta cell morphology trait male 60 days 3 61.8 % 1.2 2.08 ex vivo light microscopy with digital image analysis 0.0 0 67461 333
BN/SsNHsd hepatocellular carcinoma tumor number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 mg/kg) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 10 1.3 null 0.13 0.41 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 490 days 68389 912
SHR/FubRkb kidney glomerulus count control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 28 days 7 N(glom)=1/SSF x 1/ASF x Ps/Pf x ΣQ-/2 37000.0 null 5900.0 15609.93 ex vivo light microscopy with digital image analysis 0.0 0 per kidney 65396 117
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy (for 202.5 days) De Miglio MR, et al., Int J Cancer 2004 Aug 10;111(1):9-16. liver integrity trait male 0 days 10 19.0 % ex vivo light microscopy with digital image analysis liver 0.0 224 days 70204 1302
SHR.BN-(D3Rat159-D3Rat1)/Mco lesioned artery residual lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 13 0.35 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69316 1136
SHR/NHsd artery tunica media area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 14 0.14 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69338 1136
F344/Crli volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 3.26 cm3 x 10000 0.33 1.48 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67731 789
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 3 19.2 % 2.8 4.85 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69148 950
DRH/Seac area of individual liver tumorous lesion controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 49 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver integrity trait not specified 84 days 10 0.01 mm2 0.0 0.0 ex vivo light microscopy with digital image analysis 0.0 0 8 wks in text, inconsistent 68160 890
F344/Seac area of individual liver tumorous lesion controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 56 days) Liu H, et al., Cancer Sci 2005 Mar;96(3):164-9. liver integrity trait male 84 days 6 0.08 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 67429 750
F344.GK-(D1Rat83-D1Rat376)/Swe beta cell area to total pancreatic islet area ratio control condition Granhall C, et al., Diabetes. 2006 Dec;55(12):3494-500. pancreatic beta cell morphology trait male 60 days 3 60.2 % 1.2 2.08 ex vivo light microscopy with digital image analysis 0.0 0 67465 333
SHR/FubRkb count of superficial glomeruli not directly contacting the kidney surface control condition Schulz A, et al., J Am Soc Nephrol. 2007 Jan;18(1):113-21 kidney glomerulus quantity not specified 168 days 10 0.3 null 0.1 0.32 ex vivo light microscopy with digital image analysis 0.0 0 per section 65456 117
GK/Ox splenic region pancreatic beta cell weight calculated as the product of pancreas splenic region weight and corresponding beta cell fractional area fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 1.08 mg 0.17 0.42 ex vivo light microscopy with digital image analysis 0.0 0 68762 1012
GK/Ox calculated total pancreatic islet beta cell weight fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait male 60 days 6 2.0 mg 0.4 0.98 ex vivo light microscopy with digital image analysis 0.0 0 68766 1012
GK/Ox calculated total pancreatic islet beta cell weight fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 2.18 mg 0.33 0.81 ex vivo light microscopy with digital image analysis 0.0 0 68767 1012
SHR/NHsd artery lumen area control condition Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 18 CA = (IEL)2/4π 0.34 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68088 329
SHR/NHsd artery tunica media thickness control condition Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 18 MW=radius of entire vessel minus radius of circular area 0.04 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68092 329
SHR/NHsd artery tunica media area balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 20 0.09 mm2 ex vivo light microscopy with digital image analysis 0.0 0 media area - error - % coefficient of variation 68096 329
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 12.14 % 1.45 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days pcna index 68105 655
BN/Crl ratio of insulin-positive cell area to total area of splenic region of pancreas fasting (between 16 and 18 hours) Finlay C, et al., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29. pancreatic beta cell morphology trait female 60 days 6 0.8 % 0.1 0.24 ex vivo light microscopy with digital image analysis 0.0 0 68753 1012
DRH/Seac liver tumorous lesion number controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 140 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver integrity trait not specified 175 days 5 0.0 null 0.0 0.0 ex vivo light microscopy with digital image analysis 0.0 0 69938 890
F344/NHsd hepatocellular carcinoma tumor number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 mg/kg) (for 490 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 9 3.5 null 0.23 0.69 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 490 days 68391 912
F344/NRrrc area of individual liver tumorous lesion controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 49 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver integrity trait not specified 84 days 8 0.13 mm2 0.01 0.04 ex vivo light microscopy with digital image analysis 0.0 0 8 wks in text, inconsistent 68159 890
DRH/Seac area of liver occupied by tumorous lesions as percentage of total liver area controlled 3-methyl-4'-dimethylaminoazobenzene content diet (0.06 %) (for 49 days) Yan Y, et al., Carcinogenesis 2002 Jan;23(1):189-96. liver integrity trait not specified 84 days 10 0.15 % 0.02 0.07 ex vivo light microscopy with digital image analysis 0.0 0 8 wks in text, inconsistent % tumorous foci area in liver 68163 890
SHR.BN-(D3Rat159-D3Rat1)/Mco artery lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 13 0.39 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69313 1136
SHR.BN-(D6Rat40-D6Rat170)/Mco artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 25 12.6 % ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69317 1136
SHR.BN-(D6Rat40-D6Rat170)/Mco artery tunica media thickness control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 25 0.05 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69331 1136
SHR/NHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 15 14.96 % ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69335 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco artery neointimal hyperplastic lesion area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 17 0.04 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69342 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco artery lumen area control condition Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.52 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 0 the error is reported as +/- %CV = (standard deviation/mean) ? 100 69343 1136
SHR.BN-(D3Rat159-D3Rat1)(D6Rat40-D6Rat170)/Mco artery tunica media thickness balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery morphology trait male 126 days-140 days 17 0.05 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69349 1136
SHR/NHsd lesioned artery residual lumen area balloon angioplasty Nestor Kalinoski AL, et al., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21. iliac artery integrity trait male 126 days-140 days 15 0.42 mm2 ex vivo light microscopy with digital image analysis iliac artery 0.0 balloon vascular injury 56 days the error is reported as +/- %CV = (standard deviation/mean) ? 100 69354 1136
BN volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female 0 days 3 1.61 % 0.46 0.8 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68620 950
SS.MNS-(Mme-D2Rat131)/Ayd aorta smooth muscle cell count per unit vessel length controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. blood vessel smooth muscle cell quantity male 98 days 4 71.0 /um 4.0 8.0 ex vivo light microscopy with digital image analysis 0.0 0 /um - calculated aortic smooth muscle cell count 69033 1096
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 0.39 cm3 x 10000 0.15 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67795 655
PCK-Pkhd1pck/CrljCrl area of liver occupied by fibrotic lesions to total liver area ratio control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. liver integrity trait male 120 days 8 23.5 % 4.8 13.58 ex vivo light microscopy with digital image analysis 0.0 0 Masson¿s Trichrome staining 96913 1738
MWF kidney glomerulus volume controlled lisinopril content drinking water (80-100 mg/l) (for 140 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus morphology trait male 420 days 10 1.4 x 10E6 um3 0.08 0.25 ex vivo light microscopy with digital image analysis 0.0 0 100254 2459
F344/Jcl area of ventral prostate occupied by tumorous lesions with solid structure to total ventral prostate area ratio control condition Yamashita S, et al., Cancer Res 2005 Apr 1;65(7):2610-6. prostate integrity trait male 900 days 8 0.07 % 0.05 0.15 ex vivo light microscopy with digital image analysis 0.0 0 109892 341
AS artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 7 0.2 mm2 0.04 0.12 ex vivo light microscopy with digital image analysis 0.0 0 110458 3107
WKY/NHsd artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 0.13 mm2 0.01 0.04 ex vivo light microscopy with digital image analysis 0.0 0 110459 3107
SS/Jr artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.21 mm2 0.02 0.06 ex vivo light microscopy with digital image analysis 0.0 0 110461 3107
BN/SsNHsd artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.05 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110475 3107
Hsd:SD artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 15 20.7 % 3.71 14.37 ex vivo light microscopy with digital image analysis 0.0 0 110478 3107
WKY/NHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 27.5 % 3.5 10.5 ex vivo light microscopy with digital image analysis 0.0 0 110481 3107
LEW/SsNHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 28.0 % 4.17 13.19 ex vivo light microscopy with digital image analysis 0.0 0 110482 3107
F344/NHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 9 30.9 % 2.86 8.58 ex vivo light microscopy with digital image analysis 0.0 0 110484 3107
SHR/NHsd artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.2 mm2 0.01 0.02 ex vivo light microscopy with digital image analysis 0.0 0 110488 3107
SHR/NHsd artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 19.9 % 3.49 11.04 ex vivo light microscopy with digital image analysis 0.0 0 110490 3107
BN/SsNHsd artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 10 0.08 mm2 0.0 0.01 ex vivo light microscopy with digital image analysis 0.0 0 110492 3107
Hsd:WI kidney glomerular density control condition Freese A, etal., J Perinat Med. 2013 May;41(3):295-9. doi: 10.1515/jpm-2012-0178. kidney glomerulus quantity not specified 7 days 15 16.2 /mm3 2.9 11.23 ex vivo light microscopy with digital image analysis 0.0 0 number of glomeruli per volume of kidney (CMO:0003799) 110788 3187
BN/SsNHsd circular vessel area sham surgical control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 11 0.28 mm2 0.03 0.1 ex vivo light microscopy with digital image analysis 0.0 0 110495 3107
SHR/NHsd circular vessel area control condition Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery morphology trait male 119 days-133 days 19 0.59 mm2 0.08 0.36 ex vivo light microscopy with digital image analysis 0.0 0 110506 3107
SHR/FubRkb kidney fibrotic lesion area to total kidney area ratio control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney integrity trait female 168 days 10 4.0 % 0.2 0.63 ex vivo light microscopy with digital image analysis kidney 0.0 0 108981 3133
MWF-Chr 8SHR/Rkb kidney fibrotic lesion area to total kidney area ratio control condition Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22. kidney integrity trait male 168 days 10 7.5 % 0.3 0.95 ex vivo light microscopy with digital image analysis kidney 0.0 0 108982 3133
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 7380.0 /cm3 920.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add 67457 655
F344/NRrrc volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female 0 days 3 8.92 % 2.85 4.94 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68619 950
SS.MNS-(D2Mit6-D2Rat166)/Ayd aorta smooth muscle cell count per unit vessel length controlled sodium content diet (0.2 %) (for 14 days) then controlled sodium content diet (2 %) (for 63 days) Dutil J, et al., Physiol Genomics 2005 Mar 1;. blood vessel smooth muscle cell quantity male 98 days 8 170.0 /um 11.0 31.11 ex vivo light microscopy with digital image analysis 0.0 0 /um - calculated aortic smooth muscle cell count 69031 1096
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 9 13.8 % 0.8 2.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days remodeling/total ratio 69145 950
BN/SsNHsd artery tunica media area control condition Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 12 0.09 mm2 ex vivo light microscopy with digital image analysis 0.0 0 error - % coefficient of variation 68089 329
BN/SsNHsd artery tunica media area balloon angioplasty Nestor AL, et al., Physiol Genomics. 2006 Apr 13;25(2):286-93. Epub 2006 Jan 24. iliac artery morphology trait male 133 days-140 days 16 0.07 mm2 ex vivo light microscopy with digital image analysis 0.0 0 media area - error - % coefficient of variation 68095 329
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 2.76 % 1.1 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days pcna index 68108 655
MWF kidney sclerotic glomerular volume to total kidney glomerular volume ratio controlled lisinopril content drinking water (80-100 mg/l) (for 140 days) Macconi D, et al., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. kidney glomerulus integrity trait male 420 days 10 24.8 % 1.49 4.7 ex vivo light microscopy with digital image analysis 0.0 0 100262 2459